CN101112237B - Health products having a function of dispelling chloasma - Google Patents
Health products having a function of dispelling chloasma Download PDFInfo
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- CN101112237B CN101112237B CN2007101212055A CN200710121205A CN101112237B CN 101112237 B CN101112237 B CN 101112237B CN 2007101212055 A CN2007101212055 A CN 2007101212055A CN 200710121205 A CN200710121205 A CN 200710121205A CN 101112237 B CN101112237 B CN 101112237B
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Abstract
The invention relates to a health product provided with a function of eliminating chloasma. The active ingredients containing in the health product are: salvia miltiorrhiza extract, Chinese angelica root extract, rose extract, grape seed extract, soybean extract, pearl powder and vitamin E powder. The invention mixes the ingredients scientifically and reasonably, and then makes the mixture into preparations for oral use. The preparations are convenient in use. Experiments show that the health product can eliminate chloasma efficiently.
Description
Technical field
The present invention relates to the health food technology field, particularly relate to a kind of health products with chloasma-dispelling function.
Background technology
Along with people to the advocating and yearn for of nature, increasing people is also just strong further to the serious hope of natural beauty.Chloasma is a kind of chronic chromatodermatosis, sees with young and middle-aged women more, how to be distributed in the cheek both sides symmetrically, is filbert or coffee-like, and the likeness in form butterfly that has is so have another name called butterfly macules.The traditional Chinese medical science claims " dusty complexion ", " blackish facial patch ".Its course of disease is long, slower development, is the common difficult disease of beauty treatment section; No matter the traditional Chinese medical science or doctor trained in Western medicine be the definite treatment good medicine of inefficacy still all.Therefore, seek the removing beverage preparation of reasonable recipe, highly effective and safe, become a research focus of present pharmacy and cosmetic field.
Summary of the invention
Based on above-mentioned situation, in order to reach the beauty treatment and eliminating spot effect effectively, the invention provides that a kind of determined curative effect, short treating period, expense are low, no pain be the health products of active component with Chinese medicine, medicine of the present invention has the function of functions of removing chloasma.
Another object of the present invention provides the preparation method of above-mentioned health products.
The object of the invention also is to provide the application of above-mentioned active component in preparation treatment functions of removing chloasma product.
The present invention is achieved by the following technical solutions:
A kind of health products with chloasma-dispelling function, its contained active component comprises: Salvia root P.E, angelica extract, Flos Rosae Rugosae extract, grape seed extract, extract of soybean, pearl powder, vitamin E powder.By weight, the active component of making these health products is: Salvia root P.E 4-8 part, angelica extract 10-14 part, Flos Rosae Rugosae extract 2-6 part, grape seed extract 1-5 part, extract of soybean 2-6 part, pearl powder 1-5 part, vitamin E powder 0.5-3.5 part.Preferably, by weight, the active component of making these health products is: Salvia root P.E 5-7 part, angelica extract 11-13 part, Flos Rosae Rugosae extract 3-5 part, grape seed extract 2-4 part, extract of soybean 3-5 part, pearl powder 2-4 part, vitamin E powder 1-3 part.Best selection is, by weight, the active component of making these health products is: Salvia root P.E 5.5-6.5 part, angelica extract 11.5-12.5 part, Flos Rosae Rugosae extract 3.5-4.5 part, grape seed extract 2.5-3.5 part, extract of soybean 3.5-4.5 part, pearl powder 2.5-3.5 part, vitamin E powder 1.5-2.5 part.
Preparation of the present invention is an oral formulations; Comprise: hard shell capsules, soft capsule, granule, tablet, (acid) milk sheet, colostrum sheet, chewable tablets, honeyed bolus, concentrated honeyed bolus, water-honeyed pill, condensed water honeyed bolus, oral liquid, packed medicinal tea, decoction medicinal tea, beverage, pulvis, carbohydrate, vina, preserved fruit etc.
Described preparation also comprises auxiliary material except that active component.Calculate by weight, active component accounts for 60-90 part, and auxiliary material accounts for 10-40 part.
Described preparation technology with health products of chloasma-dispelling function comprises: get Salvia root P.E, angelica extract, Flos Rosae Rugosae extract, grape seed extract, extract of soybean, pearl powder, vitamin E powder, pulverize, sieve, mix, add auxiliary material, mixing, technology is made required preparation routinely.
The preparation method of described tablet is: get Salvia root P.E, angelica extract, Flos Rosae Rugosae extract, grape seed extract, extract of soybean, pearl powder, vitamin E powder, pulverize, sieve, add filler, mix, granulate, drying adds lubricant, mixing, compressing tablet, dressing gets tablet.
Salvia root P.E of the present invention is commercially available or adopts following method to prepare: the red sage root adds water or Different concentrations of alcohol is extracted, and concentrates drying; Or further adopt alcohol deposition method, water return in molten method, organic solvent extractionprocess, flocculent precipitation, the column chromatography one or more unite use carry out suitably refining after, pulverize, mix, sieve, check promptly gets Salvia root P.E.
Angelica extract of the present invention is commercially available or adopts following method to prepare: Radix Angelicae Sinensis adds water or Different concentrations of alcohol is extracted, and concentrates drying; Or further adopt alcohol deposition method, water return in molten method, organic solvent extractionprocess, flocculent precipitation, the column chromatography one or more unite use carry out suitably refining after, pulverize, mix, sieve, check promptly gets angelica extract.
Flos Rosae Rugosae extract of the present invention is commercially available or adopts following method to prepare: rose adds water or Different concentrations of alcohol is extracted, and concentrates drying; Or further adopt alcohol deposition method, water return in molten method, organic solvent extractionprocess, flocculent precipitation, the column chromatography one or more unite use carry out suitably refining after, pulverize, mix, sieve, check promptly gets Flos Rosae Rugosae extract.
Grape seed extract of the present invention is commercially available or adopts following method to prepare: grape pip adds water or Different concentrations of alcohol is extracted, and concentrates drying; Or further adopt alcohol deposition method, water return in molten method, organic solvent extractionprocess, flocculent precipitation, the column chromatography one or more unite use carry out suitably refining after, pulverize, mix, sieve, check promptly gets grape seed extract.
Extract of soybean of the present invention is commercially available or adopts following method to prepare: soybean adds water or Different concentrations of alcohol is extracted, and concentrates drying; Or further adopt alcohol deposition method, water return in molten method, organic solvent extractionprocess, flocculent precipitation, the column chromatography one or more unite use carry out suitably refining after, pulverize, mix, sieve, check promptly gets extract of soybean.
Chloasma is a kind of pigmented dermatosis, and the pigmented spots of filbert or brown can appear in patient's skin of face, is butterfly wing sometimes.Mostly occur at cheek and forehead, size shape differs, and the cheek portion that has is symmetrical distribution.Chloasma is the color spot that influences appearance in the pigment most, brings many worries, the especially Nian Qing Ms that likes to be beautiful to people's life.The traditional Chinese medical science is thought, the occurrence cause of chloasma has because of being subjected to ailment said due to cold or exposure (wind-heat, chill) outward, the qi and blood discord and make qi and blood can not on be person in face; Have because of eating and drinking without temperance, have a liking for the five tastes, overstrain or damage of kidney-essence person after people in middle age partially, face must not be moistened and living spot person, or, depressed rage impairing the liver unsuccessful because of feelings will, melancholy,anxiety and spleen, but fear impairing kidney etc. all mechanism of qi are disorderly contrary, or long-term nervous, unhealthy emotion such as constrain, also can seriously upset normal endocrine, also be one of chloasma major reason of continuing not disappear.Chloasma shape existing in outside, and it is because of interior, it is the signal that negative and positive of qi and blood is lacked of proper care in the body, and can reflect the prosperity and decline of function.So, Zhi Qiben, just should be based on internal therapy, outside interior supporting.General Coryza Treated by Syndrome Differentiation, as with clearing lung-heat, yin-nourishing, invigorate blood circulation, oral medicinal herb such as soothing the liver treats, and can receive certain effect really.But take decoction of medicinal ingredients some usually because of can not adhering to, the effect of giving up halfway does not show.Because of the origin cause of formation of chloasma, except that with reasons such as lung heat, liver depression, the deficiency of Yin, all be unable to do without qi depression to blood stasis.
In forming active ingredient of the present invention, red sage root blood circulation promoting nourishes blood, removing blood stasis for promoting tissue regeneration improve facial microcirculation, and blood is worked freely, and last honor is supplemented nutrition facial capillary in face, and chloasma fades.Radix Angelicae Sinensis has the endocrine function of adjusting hypophysis-ovary, can improve Hemorheology and microcirculation; The effect of extremely strong restraint of tyrosinase activity is arranged, thereby but resident sense of youth is given in the appearance of delay senility sign.Oxidation-resistant active ingredient in the rose, not only has the effect of removing excessive free radicals in the body more by force, the integrality that keeps membrane structure and large biological molecule structure, make it the function of bringing into normal play, and can improve the gene expression amount of most important class of enzymes SOD in the antioxidant system, make SOD keep the high activity state, the oxidation resistant the first line of defence of body is strengthened; By acting synergistically mutually with various anti-oxidative defense system in the upper body, remove the excessive free radicals that body produces timely and effectively, keep normal physiological state and metabolic activity in the body, play function in delaying senility.Isoflavones can significantly reduce chloasma colourity, reduces the chloasma area, and does not have new chloasma generation.Pearl has delaying senility function, the light base Europe squama amino acid that is contained in the pearl powder is a kind of special moistening composition, skin to the people has compatibility, can make skin recover original moist, can promote the thermal energy oxidation of Skin Cell to supply with, make intracellular movable upsweep, impel skin moistening, fine and smooth; Can repair damaged cell, promote the supply of nutrition, make coarse skin recover gloss, keep moistening; Can increase the skin blood circulation, suppress the growth of lipofuscin in the body, impel cell viability to increase, delaying cell aging promotes the regeneration of epidermal cell, makes the skin softness, and wrinkle, freckle are eliminated; Can regulate physiological function, promote people's bulk-growth, make the cellular-restoring vigor, thereby make skin have gloss.A large amount of polyphenols-the OPCs that contain in the grape seed extract, it is appropriately crosslinked that OPC can promote that collagen forms on the one hand; On the other hand,, can prevent the generation of the unusual physiological situation of skin " excessively crosslinked ", thereby also just stop the appearance of wrinkle of skin and vesica, keep the submissive smooth of skin as a kind of effective free radical scavenger.Vitamin E has stronger anti-radical action.Above-mentioned active component prescription plays the function of eliminating chloasma.
The present invention is foundation with the theory of traditional Chinese medical science, adopts the above-mentioned active component prescription that cooperatively interacts, and various result of the tests show that it is definite effect aspect functions of removing chloasma, shows that its active ingredient components cooperates in order, effectively functions of removing chloasma.
Below situation illustrates beneficial effect of the present invention by experiment:
Carry out human feeding trial, the minimizing of test chloasma area.
The test-meal group: capsule of the present invention for oral administration, given the test agent gives 30 days time, and the experimenter stops using other articles for use oral and the relevant face-beautifying and spot-removing of external application at duration of test, does not change original eating habit, normal diet.Test-meal number 50 people.
Control group: take placebo; Test-meal number 50 people.
Women's head-ornaments portion chloasma area size, shade before and after the test-meal are measured.
Effectively: chloasma color decline I degree, area reduces greater than 20%, and does not produce new chloasma.
Invalid: chloasma color and area do not have significant change
Effective 42 people of result, invalid 8 people.
Result of the test shows that test-meal group chloasma area decreased average is greater than 20%, and the color integration obviously descends, relatively reach before and after self with control group and compare, differentiating all has conspicuousness, and does not produce new chloasma, and this given the test agent of decidable has the effect of functions of removing chloasma.
Concrete embodiment
Embodiment 1: Salvia root P.E 75g, angelica extract 150g, Flos Rosae Rugosae extract 50g, grape seed extract 37.5g, extract of soybean 50g, pearl powder 37.5g, vitamin E powder 25g, microcrystalline cellulose 123.8g, dolomol 1.65g
Get Salvia root P.E, angelica extract, Flos Rosae Rugosae extract, grape seed extract, extract of soybean, pearl powder, the vitamin E powder (50% dry powder) of recipe quantity, pulverize, sieve, add the microcrystalline cellulose of recipe quantity, mix, granulate, drying adds dolomol, compressing tablet, dressing gets tablet.
Embodiment 2: Salvia root P.E 50g, angelica extract 125g, Flos Rosae Rugosae extract 25g, grape seed extract 12.5g, extract of soybean 25g, pearl powder 12.5g, vitamin E powder 6.25g, lactose 100g, dextrin 41.75g, talcum powder 2g
Get Salvia root P.E, angelica extract, Flos Rosae Rugosae extract, grape seed extract, extract of soybean, pearl powder, the vitamin E powder (50% dry powder) of recipe quantity, pulverize, sieve, add lactose, the dextrin of recipe quantity, mixing, granulate, drying adds talcum powder, mixing, can gets capsule.
Embodiment 3: Salvia root P.E 100g, angelica extract 175g, Flos Rosae Rugosae extract 75g, grape seed extract 62.5g, extract of soybean 75g, pearl powder 62.5g, vitamin E powder 43.75g, pregelatinized starch 53.05g, superfine silica gel powder 13.2g
Get Salvia root P.E, angelica extract, Flos Rosae Rugosae extract, grape seed extract, extract of soybean, pearl powder, the vitamin E powder (50% dry powder) of recipe quantity, pulverize, sieve, the pregelatinized starch that adds recipe quantity, mixing adds superfine silica gel powder 13.2g, mixing, granulate, packing promptly gets granule.
Embodiment 4: Salvia root P.E 62.5g, angelica extract 137.5g, Flos Rosae Rugosae extract 37.5g, grape seed extract 25g, extract of soybean 37.5g, pearl powder 25g, vitamin E powder 12.5g, sweet mellow wine 210g, aspartame 11g, dolomol 1.5g
Get Salvia root P.E, angelica extract, Flos Rosae Rugosae extract, grape seed extract, extract of soybean, pearl powder, the vitamin E powder (50% dry powder) of recipe quantity, pulverize, sieve, the sweet mellow wine, aspartame, the dolomol that add recipe quantity, mixing is granulated drying, compressing tablet gets chewable tablets.
Embodiment 5: Salvia root P.E 87.5g, angelica extract 162.5g, Flos Rosae Rugosae extract 62.5g, grape seed extract 50g, extract of soybean 62.5g, pearl powder 50g, vitamin E powder 37.5g, xylitol 222.5g, dolomol 7.5g, talcum powder 7.5g
Get Salvia root P.E, angelica extract, Flos Rosae Rugosae extract, grape seed extract, extract of soybean, pearl powder, the vitamin E powder (50% dry powder) of recipe quantity, pulverize, sieve, the xylitol, dolomol, the talcum powder that add recipe quantity, mixing is pulverized, packing promptly gets granule.
Embodiment 6: Salvia root P.E 68.75g, angelica extract 143.75g, Flos Rosae Rugosae extract 43.75g, grape seed extract 31.25g, extract of soybean 43.75g, pearl powder 31.25g, vitamin E powder 18.75g, starch 100g, calcium monohydrogen phosphate 18.75g
Get Salvia root P.E, angelica extract, Flos Rosae Rugosae extract, grape seed extract, extract of soybean, pearl powder, the vitamin E powder (50% dry powder) of recipe quantity, pulverize, sieve, add starch, the calcium monohydrogen phosphate of recipe quantity, technology is prepared into solid orally ingestible routinely.
Embodiment 7: Salvia root P.E 81.25g, angelica extract 156.25g, Flos Rosae Rugosae extract 56.25g, grape seed extract 43.75g, extract of soybean 56.25g, pearl powder 43.75g, vitamin E powder 31.25g, polyethylene glycol 131.25g
Get Salvia root P.E, angelica extract, Flos Rosae Rugosae extract, grape seed extract, extract of soybean, pearl powder, the vitamin E powder (50% dry powder) of recipe quantity, pulverize, sieve, add the polyethylene glycol of recipe quantity, be prepared into solid orally ingestible according to a conventional method.
Salvia root P.E of the present invention is commercially available or adopts following method to prepare: the red sage root adds water or Different concentrations of alcohol is extracted, and concentrates drying; Or further adopt alcohol deposition method, water return in molten method, organic solvent extractionprocess, flocculent precipitation, the column chromatography one or more unite use carry out suitably refining after, pulverize, mix, sieve, check promptly gets Salvia root P.E.Press dry product and calculate, the content of tanshin polyphenolic acid B must not be lower than 3%.
Angelica extract of the present invention is commercially available or adopts following method to prepare: Radix Angelicae Sinensis adds water or Different concentrations of alcohol is extracted, and concentrates drying; Or further adopt alcohol deposition method, water return in molten method, organic solvent extractionprocess, flocculent precipitation, the column chromatography one or more unite use carry out suitably refining after, pulverize, mix, sieve, check promptly gets angelica extract.
Flos Rosae Rugosae extract of the present invention is commercially available or adopts following method to prepare: rose adds water or Different concentrations of alcohol is extracted, and concentrates drying; Or further adopt alcohol deposition method, water return in molten method, organic solvent extractionprocess, flocculent precipitation, the column chromatography one or more unite use carry out suitably refining after, pulverize, mix, sieve, check promptly gets Flos Rosae Rugosae extract.
Grape seed extract of the present invention is commercially available or adopts following method to prepare: grape pip adds water or Different concentrations of alcohol is extracted, and concentrates drying; Or further adopt alcohol deposition method, water return in molten method, organic solvent extractionprocess, flocculent precipitation, the column chromatography one or more unite use carry out suitably refining after, pulverize, mix, sieve, check promptly gets grape seed extract.Press dry product and calculate, the content of OPC must not be lower than 80%.
Extract of soybean of the present invention is commercially available or adopts following method to prepare: soybean adds water or Different concentrations of alcohol is extracted, and concentrates drying; Or further adopt alcohol deposition method, water return in molten method, organic solvent extractionprocess, flocculent precipitation, the column chromatography one or more unite use carry out suitably refining after, pulverize, mix, sieve, check promptly gets extract of soybean.
Claims (7)
1. health products with chloasma-dispelling function, it is characterized in that, calculate by weight, the active component of making these health products is: Salvia root P.E 4-8 part, angelica extract 10-14 part, Flos Rosae Rugosae extract 2-6 part, grape seed extract 1-5 part, extract of soybean 2-6 part, pearl powder 1-5 part, vitamin E powder 0.5-3.5 part.
2. a kind of health products according to claim 1 with chloasma-dispelling function, it is characterized in that, calculate by weight, the active component of making these health products is: Salvia root P.E 5-7 part, angelica extract 11-13 part, Flos Rosae Rugosae extract 3-5 part, grape seed extract 2-4 part, extract of soybean 3-5 part, pearl powder 2-4 part, vitamin E powder 1-3 part.
3. a kind of health products according to claim 2 with chloasma-dispelling function, it is characterized in that, calculate by weight, the active component of making these health products is: Salvia root P.E 5.5-6.5 part, angelica extract 11.5-12.5 part, Flos Rosae Rugosae extract 3.5-4.5 part, grape seed extract 2.5-3.5 part, extract of soybean 3.5-4.5 part, pearl powder 2.5-3.5 part, vitamin E powder 1.5-2.5 part.
4. according to each described a kind of health products of claim 1-3 with chloasma-dispelling function, it is characterized in that, described preparation is an oral formulations, comprising: hard shell capsules, soft capsule, granule, tablet, honeyed bolus, oral liquid, packed medicinal tea, decoction medicinal tea, pulvis, vina.
5. a kind of health products with chloasma-dispelling function according to claim 4 is characterized in that described preparation is an oral formulations, comprising: sour milk tablet, colostrum sheet, chewable tablets, concentrated honeyed bolus, water-honeyed pill, condensed water honeyed bolus.
6. according to claim 4 or 5 described a kind of health products with chloasma-dispelling function, described preparation also comprises auxiliary material except that active component, it is characterized in that, calculates by weight, and active component accounts for 60-90 part, and auxiliary material accounts for 10-40 part.
7. according to the preparation method of the tablet of any described a kind of health products with chloasma-dispelling function of claim 1-3: it is characterized in that, get Salvia root P.E, angelica extract, Flos Rosae Rugosae extract, grape seed extract, extract of soybean, pearl powder, vitamin E powder, pulverize, sieve, add filler, mixing, granulation, drying, adding lubricant, mixing, compressing tablet, dressing get tablet.
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| CN2007101212055A CN101112237B (en) | 2007-08-31 | 2007-08-31 | Health products having a function of dispelling chloasma |
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| CN2007101212055A CN101112237B (en) | 2007-08-31 | 2007-08-31 | Health products having a function of dispelling chloasma |
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| CN101112237B true CN101112237B (en) | 2010-12-22 |
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| CN101401878B (en) * | 2008-11-12 | 2012-08-29 | 东方药林药业有限公司 | Chinese medicinal composition for beauty treatment and face nursing, and preparation method thereof |
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| CN101703127B (en) * | 2009-09-17 | 2013-01-02 | 杭州六易科技有限公司 | Method for preparing beverage having effect of dispelling spots |
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| CN106490623A (en) * | 2016-10-28 | 2017-03-15 | 芜湖市诺康生物科技有限公司 | A kind of with the compositionss for improving moisture of skin function |
| CN108607021A (en) * | 2016-12-12 | 2018-10-02 | 上海交大昂立股份有限公司 | A kind of edible health care product and its preparation process of the physical fatigue that eases up with functions of removing chloasma |
| CN106962706A (en) * | 2017-03-29 | 2017-07-21 | 安徽阜南常晖食品有限公司 | A kind of grape pip rose flavored juice |
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