CN1201775C - Medicine for treating insomnia-sleeping particle and preparation thereof - Google Patents
Medicine for treating insomnia-sleeping particle and preparation thereof Download PDFInfo
- Publication number
- CN1201775C CN1201775C CN 02144939 CN02144939A CN1201775C CN 1201775 C CN1201775 C CN 1201775C CN 02144939 CN02144939 CN 02144939 CN 02144939 A CN02144939 A CN 02144939A CN 1201775 C CN1201775 C CN 1201775C
- Authority
- CN
- China
- Prior art keywords
- medicine
- insomnia
- parts
- water
- volatile oil
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention relates to a medicine for treating insomnia, which is characterized in that the medicine is prepared from the following Chinese herbal medicines according to parts by weight: 800 to 1200 parts of baical skullcap root, 500 to 700 parts of flavescent sophora root, 700 to 750 parts of cape jasmine fruit, 450 to 550 parts of grassleaf sweelflag rhizome and 450 to 550 parts of polygala root. The medicine is a granular preparation for oral administration and is a mixture of a beta-cyclodextrin inclusion compound of the volatile oil of the grassleaf sweelflag rhizome, a dry extract of the baical skullcap root, the flavescent sophora root, the cape jasmine fruit, the grassleaf sweelflag rhizome and the polygala root with water, and starch gum; 1500 to 3500g of the medicinal materials are prepared into 1000g of the granular preparation, wherein 1000g of the granular preparation comprises 10 to 30g of the beta-cyclodextrin inclusion compound, 370 to 500g of the dry extract and starch gum as the rest. As a pure traditional Chinese medicine preparation for treating phlegm-heat internally attacking type insomnia, the sleeping granules of the present invention has the functions of removing heat-phlegm, relieving mental stress, advancing time for falling asleep, prolonging the duration time of sleep, reducing the number of times of awaking each night, increasing the total amount of sleep every day and curing the symptoms of insomnia. The medicine has outstanding curative effects, rapid effect taking, reliable administration and no toxic and side effect, the total effective rate of the medicine reaches 96.7%, and thus, the present invention is a relatively ideal traditional Chinese medicine preparation for insomnia at present.
Description
Technical field:
The present invention relates to the medicine of Cure for insomnia, a kind of Chinese patent medicine of Cure for insomnia---sleeping pill is provided especially.
Background technology:
Along with science and technology development, the fierceness day by day of the market competition, the quickening of people's rhythm of life, stress is also increasing, and insomnia promptly becomes current commonly encountered diseases and frequently-occurring disease.Insomnia in Chinese medicine, be commonly referred to be insomnia, insomnia, insomnia crouch, must not doss etc.The primary disease origin cause of formation be it is generally acknowledged, and ponders over overstrain, interior sad spleen, and disarmony between the heart and kidney, hyperactivity of fire caused by deficiency of YIN, the liver-yang disturbance, factors such as the heart and gallbladder deficiency of vital energy and disorder of the stomach are relevant.Its syndrome performance can divide deficiency and excess two classes substantially.Its empty person, pathogenesis or be deficiency of both the heart and spleen, so that irritability; Or kidney yin consumption hinders, can not on help in the heart, heart-yang is solely high, heart-fire can not meet at kidney down, disturbs and gods and can not falling asleep; Or hinder in feelings will, liver is lost bar and reaches, stagnated QI transforming into fire, and yang hyperactivity is cloudy hinders, and the disturbance mind consequently is insomnia; Or timidness due to deficiency of the heart, easily frightened when anything crops up, irritability and having a sleepless night.Can notice that multiple the looking from the deficiency syndrome opinion of doctor family controlled insomnia at all times, all belongs to this type of as successive dynasties name side's suanzaoren decoction, GUIPI TANG, Chinese goldthread colla corii asini decoction, tranquilizing the mind ball etc.The true person that has a sleepless night, its pathogenesis or because of angry impairing the liver, liver is lost bar and reaches, stagnated QI transforming into fire, disturbing the mind upwards and being insomnia; Or because of " disorder of the stomach leading to insomnia with restlessness " (" element is asked the contrary opinion of transferring "); Or phlegm-damp stops up and to hold back middle Jiao, and the strongly fragrant heat of giving birth to of a specified duration is disturbed and dysphoria and insomnia on the expectorant heat.Used representative prescription has Decoction of Gentiana for Purging the Liver-fire, Rhizoma Pinelliae Sorghum vulgare Pers. soup etc.But it is less comparatively speaking, to control the insomniac from positivism.
Analyze the insomnia card and control heavy deficiency syndrome and the reason of light excess syndrome, may in facing card, see more asthenia, weak, neurolysis, dispirited, vexed, lose heart, indigestion and loss of appetite, state such as become thin is relevant.The appearance of in fact this state is to cause because of lying awake all night in essence.The i.e. highly excited being seen excess syndrome performance of spirit at nightfall causes the weak state when facing card.In view of this, pay attention to as if more catching the essence of pathological changes to the treatment of insomnia excess syndrome.
Can notice that in all excess syndromes of insomnia, syndrome of phlegm-heat attacking internally is more common pattern of syndrome.Suffer from the patient except that seeing insomnia, the symptom relevant with card is vexed such as vexed regretful Nang, breast gastral cavity painful abdominal mass, has a dizzy spell, and bitter taste etc. are more common, and yellowish fur and slippery and rapid pulse can further be assert the hot attribute of expectorant of pattern of syndrome.The patient who has then shows as feature with typical tongue, arteries and veins.
The technology contents of invention:
The object of the present invention is to provide a kind of medicine of Cure for insomnia, it has removing heat-phlegm, anti-tired effect of calming the nerves; Clinically be used for the syndrome of phlegm-heat attacking internally insomnia.
The invention provides a kind of medicine of Cure for insomnia, it is characterized in that its ingredient is that Chinese herbal medicine by following weight portion is prepared from:
800～1200 parts of Radix Scutellariaes;
500～700 parts of Radix Sophorae Flavescentiss;
700～750 parts of Fructus Gardeniaes;
450～550 parts of Rhizoma Acori Graminei;
450～550 parts of Radix Polygalaes.
In the prescription of Cure for insomnia medicine provided by the invention, the Radix Scutellariae bitter cold, the GUIXIN warp is the product of clearing away heat-fire, kind " fire of the clear part of the body cavity above the diaphragm housing the heart and lungs " (" book on Chinese herbal medicine is just "), heat is clearly then tired to be removed, and is tired of and removes then refreshing peace, consumption maximum in the side, the duty of taking charge of monarch drug.
The Radix Sophorae Flavescentis bitter cold, the also agent of heat clearing away, energy " settling five organs, sedate " (" Mingyi Bielu "); The Fructus Gardeniae bitter cold is gone into heart channel, " treats heart channel exopathogenic heat, removes irritated " (" medicine origin "), " controlling vexed regretful Nang and insomnia " (" medicine class on the analogy of natural things ").The auxiliary Radix Scutellariae clearing away heat-fire of this 2 flavor is ministerial drug in the side altogether.
Rhizoma Acori Graminei is the agent of hot tepor, the GUIXIN warp, and the main eliminating phlegm of having one's ideas straightened out can " remove the motive, the smooth mind, happy mood, beneficial will " (" Chongqing hall random notes "), " removing unhappy " (" Japan hanako materia medica "); Radix Polygalae toil temperature is gone into heart channel, is longer than the resolving depression that eliminates the phlegm, can " gas of feeling relieved, spasmolytic is throbbed with fear " (" Mingyi Bielu "), and " relieving convulsion mind calming " (" the southern regions of the Yunnan Province book on Chinese herbal medicine ").Two medicines stress to eliminate the phlegm, and assistant helps monarch, all product of minister, is adjuvant drug.
Prescription of the present invention, using medicines of both cold and hot natures simultaneously, property is relatively cold.The heat clearing away of advocating of Radix Scutellariae, Radix Sophorae Flavescentis, Fructus Gardeniae 3 flavors, Rhizoma Acori Graminei, Radix Polygalae are specially in eliminating the phlegm.Full square structure is rigorous, and the division of labor is clear and definite, and flavour of a drug are specially smart, and pathogenesis hits.Hot clearing away phlegm disappears, and can receive the effect of sleeping peacefully.
Owing to contain a large amount of macromolecular compounds in the prescription of the present invention, be the effective ingredient of treatment, so select for use solid dosage forms comparatively suitable.According to result of the test, the paste-forming rate of prescription Chinese crude drug of the present invention is about 10.5%, and as adopting capsule, by every 0.5g, then each dose is the 6-8 grain; Adopt tablet, by every .3g, each dose is about 10; And the employing granule, by every bag of 10g, each dose only is 1 bag, so be granule dosage form---sleeping pill really finally.
Particularly, the medicine of Cure for insomnia of the present invention---sleeping pill is the beta-cyclo dextrin included compound of Rhizoma Acori Graminei volatile oil, the water extract dry extract of Radix Scutellariae, Radix Sophorae Flavescentis, Fructus Gardeniae, Rhizoma Acori Graminei, Radix Polygalae and the mixture of dextrin; 1500～3500 gram medical materials can be made into the finished particle agent of 1000 grams, and wherein beta-cyclo dextrin included compound 10～30 restrains, dry extract 370～500 grams, dextrin surplus.
According to document announcement: containing a certain amount of volatile oil in the Rhizoma Acori Graminei medical material, is its effective ingredient, has the central nervous system of inhibition effect, and insomnia is had better effect, and its decocting liquid also has certain soporific function; The water solublity of effective ingredient such as the baicalin in Radix Scutellariae, Radix Sophorae Flavescentis, Fructus Gardeniae and the Radix Polygalae, Radix Sophorae Flavescentis total alkaloids, iridoid glycoside is fine, be fit to use water extraction, so in technical study, adopted elder generation with Rhizoma Acori Gramineii extract volatile oil, residue and Radix Scutellariae, Radix Sophorae Flavescentis, Fructus Gardeniae and Radix Polygalae medical material mixing and water adding decoct; Again with the process route of volatile oil with beta-cyclodextrin inclusion compound.
Particularly, the medicine of Cure for insomnia of the present invention---the preparation process of sleeping pill is as follows:
With Rhizoma Acori Graminei extracting in water volatile oil, aqueous extract is put in addition, and volatile oil adds the beta-schardinger dextrin-saturated solution, stirs, and refrigerator is placed, and filters, and oven drying at low temperature is ground into fine powder;
Rhizoma Acori Graminei residue and Radix Scutellariae, Radix Sophorae Flavescentis, Fructus Gardeniae, Radix Polygalae medical material mixing and water adding are decocted 3 times, filtrate and above-mentioned volatile oil aqueous extract merge, and are concentrated into the clear paste of relative density 1.10～1.14, and alcohol is sink to relative density 1.25～1.30, drying under reduced pressure is ground into fine powder to doing;
The beta-cyclo dextrin included compound fine powder of above-mentioned Rhizoma Acori Graminei volatile oil, above-mentioned water extract fine powder are mixed with dextrin, add ethanol and make granule, drying, packing is promptly.
Sleeping pill of the present invention has removing heat-phlegm, the function of mind tranquilizing and the heart calming as the pure Chinese medicinal preparation of treatment type of phlegm-heat attacking internally insomnia, can make time for falling asleep in advance, prolong sleep time, reduce the number of times of awakening every night, increase a day sleep total amount, improve insomnia, determined curative effect, and also onset is rapid, take safe and reliable, have no side effect, total effective rate is up to 96.7%, is the Chinese medicine preparation of at present more satisfactory Cure for insomnia.
The specific embodiment:
The preparation of embodiment 1 sleeping pill
Prescription: Radix Scutellariae 1000g, Radix Sophorae Flavescentis 600g, Fructus Gardeniae 733g, Rhizoma Acori Graminei 500g, Radix Polygalae 500g.
The above five tastes, Rhizoma Acori Graminei add 6 times of amounts of water and soaked 2 hours, extract volatile oil 8 hours, and other preserves by device respectively for volatile oil and aqueous extract; Residue and all the other four Chinese medicine material mixing and water addings decoct three times, and amount of water is respectively 10 times, 8 times and 8 times, and extraction time was respectively 1 hour, 1 hour and 0.5 hour.Filtrate and volatile oil aqueous extract merge, when being concentrated into the clear paste of relative density 1.10～1.14 (60 ℃), add 2 times of amount ethanol precipitate with ethanol, make the solution determining alcohol reach 30%, standing over night is got supernatant and is reclaimed ethanol to relative density 1.25～1.30 (60 ℃), and drying under reduced pressure is to doing, be ground into fine powder, standby; Get volatile oil and add the beta-schardinger dextrin-saturated solution, stir, refrigerator is placed, and filters, and oven drying at low temperature is ground into fine powder, mixes in right amount with water extract fine powder such as Radix Scutellariae and dextrin, adds ethanol to make granule in right amount, and drying is made 1000g, promptly.
The Pharmacodynamic test of active extract of embodiment 2 sleeping pills
1. test material
1.1 be subjected to the reagent thing: sleeping pill, embodiment 1 preparation contains crude drug amount 33.3g/10g.Positive control Chinese medicine resolving stagnation for tranquilization electuary, Fu Dong pharmaceutical Co. Ltd in Shenyang produces " zz-2845-the Liao Dynasty defends the accurate word (1996) of medicine No. 0278 " lot number: 990402; Positive control Western medicine diazepam, Shenyang Keda Pharmaceutical Factory of Dongbei Pharmaceutical Group Corp. produces " the Liao Dynasty defends the accurate word (1996) of medicine No. 004044 " lot number: 980601.Be subjected to reagent thing and positive control Chinese medicine all to be made into the desired concn suspension, be for experiment with distilled water.
1.2 animal subject: Kunming kind white mice, the qualified laboratory animal of one-level, laboratory animal portion of Chinese Medical Sciences University provides, and the real bar of quality certification the Liao Dynasty closes word No. 1 and distant essence is closed word 008.
1.3 reagent: pentobarbital sodium, the SERVA packing, the chemical plant is known in last sea-run, lot number: 921019.Strychnine nitrate, Shanghai Hefeng Pharmaceutical Co., Ltd., the accurate word (94) of medicine is defended No. 133-010 in Shanghai, lot number: 960301.
The program control autonomic activities instrument of 1.4 instrument: ZIL-2, Chinese medical courses in general institute medicine grind produce.
2. test method and result
2.1 sleeping pill is to the influence of pentobarbital sodium subliminal hypnosis amount effect
Get 60 of 18～22g healthy mices, fasting be can't help water 17 hours, divided six groups at random by body weight, every group of 10 male and female half and half.Gastric infusion, administration volume are 1ml/20g, once a day, successive administration 3 days, matched group gavages the isometric(al) distilled water.After the last administration 50 minutes, lumbar injection 30mg/kg pentobarbital sodium as sleeping index, was used X with the Mus number of mice righting reflex loss more than 1 minute in after the administration 15 minutes
2The value check administration group and the matched group significance of difference the results are shown in Table 1.
Table 1 sleeping pill is to the influence of white mice pentobarbital sodium subliminal hypnosis amount effect
The sleeping number of animals sleep of group dosage number of animals percentage rate
G/kg (only) (only) (%)
Blank group equivalent distilled water 10 2 20
Stable group 0.003 10 10 100
*
Resolving stagnation for tranquilization electuary 3.6 10 5 50
The high dose group of sleeping peacefully 10.4 10 10 100
*
Dosage group 5.2 10 8 80 in sleeping peacefully
*
The low dose group 2.6 10 6 60 of sleeping peacefully
*P＜0.01 (with blank group ratio)
Result of the test shows that sleeping pill height, middle dosage have the effect of increase to pentobarbital sodium subliminal hypnosis amount white mice sleep number.
2.2 sleeping pill is to the influence of white mice pentobarbital sodium syngignoscism
Get 60 of 18～22g healthy mices, fasting be can't help water 17 hours, divided six groups at random by body weight, every group of 10 male and female half and half.Gastric infusion, administration volume are 1ml/20g, once a day, successive administration to 3 day, matched group gavages equal-volume water.After the last administration 50 minutes, press literature method lumbar injection 40mg/kg pentobarbital sodium, time of record sleep appearing and subsiding then is index with the time length of mice sleep after the administration, compare the administration group and the matched group significance of difference with the t method of inspection, the results are shown in Table 2.
Table 2 sleeping pill is to the influence of white mice pentobarbital sodium syngignoscism
Group dosage number of animals is kept the length of one's sleep (branch)
G/kg (only) X+SD
Blank group equivalent distilled water 10 21.30+14.06
Stable group 0.003 10 103.3+53.22
*
Resolving stagnation for tranquilization electuary 3.6 10 33.60+35.31
The high dose group of sleeping peacefully 10.4 10 60.80+25.41
*
Dosage group 5.2 10 58.10+30.12 in sleeping peacefully
*
The low dose group of sleeping peacefully 2.6 10 52.90+13.14
*
*P＜0.01 (with blank group ratio)
Result of the test shows that sleeping pill can prolong the time of white mice pentobarbital sodium syngignoscism.
2.3 sleeping pill is to the influence of white mice spontaneous activity
Get 60 of 18～22g healthy mices, fasting be can't help water 17 hours, divided six groups at random by body weight, and 10 every group, male and female half and half.Gastric infusion, administration volume are 1ml/20g, once a day, successive administration to 3 day, matched group gavages the isometric(al) distilled water.After the last administration 30 minutes, survey spontaneous activity in mice number of times in 10 minutes with program control autonomic activities case.Between organizing with T check relatively.
Table 3 sleeping pill is to the influence of white mice spontaneous activity effect
Group dosage number of animals activity number of times (10 minutes)
G/kg (only) X+SD
Blank group equivalent distilled water 10 603.30+68.18
Stable group 0.003 10 275.70+82.80
*
Resolving stagnation for tranquilization electuary 3.6 10 360.90+128.30
*
The high dose group of sleeping peacefully 10.4 10 354.30+76.00
*
Dosage group 5.2 10 400.80+111.01 in sleeping peacefully
*
The low dose group of sleeping peacefully 2.6 10 426.30+182.70
*
*P＜0.01 (with blank group ratio)
Result of the test shows that sleeping pill can obviously suppress white mice spontaneous activity number of times.
2.4 the influence that sleeping pill is fainted from fear to the white mice strychnine
Get 60 of 18～22g healthy mices, fasting be can't help water 17 hours, divided six groups at random by body weight, and 10 every group, male and female half and half.Gastric infusion, administration volume are 1ml/20g, once a day, successive administration to 7 day, matched group gavages the isometric(al) distilled water.After the last administration 50 minutes, each organized subcutaneous injection 1.2mg/kg strychnine nitrate, is index tonic convulsion to occur, and record takes place by the incubation period of tonic convulsion.Between organizing with T check relatively.
Table 4 sleeping pill causes the influence that white mice is fainted from fear to strychnine
The incubation period of group dosage number of animals-generation tonic convulsion
G/kg (only) X+SD (second)
Blank group equivalent distilled water 10 428.2+187.09
Stable group 0.003 10 633.6+242.90
*
Resolving stagnation for tranquilization electuary 3.6 10 594.5+272.80
The high dose group of sleeping peacefully 10.4 10 635.5+154.40
*
Dosage group 5.2 10 625.0+219.50 in sleeping peacefully
*
The low dose group of sleeping peacefully 2.6 10 573.60+152.70
*P＜0.05 (with blank group ratio)
Result of the test shows that the white mice convulsions sleeping pill high dose group that strychnine is caused has the preclinical effect that prolongs tonic convulsion.
3. experiment conclusion
Result of the test shows, sleeping pill height, middle dosage group have the effect of increase to pentobarbital sodium subliminal hypnosis amount white mice sleep number, and sleeping pill can prolong the time of white mice pentobarbital sodium syngignoscism.Sleeping pill can obviously suppress white mice spontaneous activity number of times.The white mice that the sleeping pill high dose group causes strychnine is fainted from fear the preclinical effect that prolongs tonic convulsion.This results of pharmacodynamic test provides reference for clinical application.
The 30 routine clinical trial brief summaries of embodiment 3 sleeping pills
Clinical data
All are tried case 110 examples all from the Liaoning Prov. Traditional Chinese Medicine Inst outpatient service.Test group 30 examples (hereinafter to be referred as A group) wherein, matched group is established 2 groups, is respectively 50 examples and 30 examples (organizing hereinafter to be referred as B group, C).3 groups of cases compare in sex, age, the state of an illness, course of disease several respects, and statistical result shows there was no significant difference (P＞0.05), shows to have harmony and comparability between group.
Conclusion
1. by clinical observation to 30 routine 3 weeks of insomniac, the total effective rate of sleeping pill is 96.7%, is higher than brain-invigorating capsule 94%, the curative effect of mind-easing tonic bolus with arborvitate seed 76.7%, significant difference on the statistics (P＜0.01) illustrates that this medicine is better than contrasting medicine on general curative effect.
2. sleeping pill is compared with two kinds of contrast medicines the improvement of insomnia, diversity highly significant (P＜0.01), and dizzy curative effect and two medicines are maintained an equal level, to also presenting significant difference (P＜0.01) before and after other all symptoms, the sign treatment, have statistical significance.Point out this medicine can directly improve sleep quality, can improve other symptom again, come Cure for insomnia by the integral body adjustment.
3. the onset of this medicine is rapid, the 1st when week total effective rate reached 70%, and the course of treatment, length was influential to obtaining of curative effect, the 2nd, 3 weeks are significantly better than the 1st week, significant difference on the statistics (P＜0.01).
4. this medicine is applicable to the patient of different sexes, the different course of disease and the state of an illness, but better than two kinds of contrast medicines to the curative effect of female patient.
5. sleeping pill is to the bright contrast medicine that is better than of 36～55 years old insomniac's therapeutic effect, diversity significantly (P＜0.05 or P＜0.01) on the statistics; And 46～55 years old insomniac's curative effect is better than other age bracket.
6. this medicine is taken safe and reliablely in the phase course of treatment, does not find other toxic and side effects and untoward reaction.
Claims (5)
1, a kind of medicine of Cure for insomnia is characterized in that its ingredient is that Chinese herbal medicine by following weight portion is prepared from:
800～1200 parts of Radix Scutellariaes;
500～700 parts of Radix Sophorae Flavescentiss;
700～750 parts of Fructus Gardeniaes;
450～550 parts of Rhizoma Acori Graminei;
450～550 parts of Radix Polygalaes.
2, by the medicine of the described Cure for insomnia of claim 1, it is characterized in that described medicine is a granular preparations for oral administration, is the beta-cyclo dextrin included compound of Rhizoma Acori Graminei volatile oil, the water extract dry extract of Radix Scutellariae, Radix Sophorae Flavescentis, Fructus Gardeniae, Rhizoma Acori Graminei, Radix Polygalae and the mixture of dextrin; The finished particle agent that 1500～3500 gram medical materials are made 1000 grams, wherein beta-cyclo dextrin included compound 10～30 restrains, dry extract 370～500 grams, dextrin surplus.
3, the preparation method of the medicine of the described Cure for insomnia of a kind of claim 2 is characterized in that preparation process is as follows:
With Rhizoma Acori Graminei extracting in water volatile oil, aqueous extract is put in addition, and volatile oil adds the beta-schardinger dextrin-saturated solution, stirs, and refrigerator is placed, and filters, and oven drying at low temperature is ground into fine powder;
Rhizoma Acori Graminei residue and Radix Scutellariae, Radix Sophorae Flavescentis, Fructus Gardeniae, Radix Polygalae medical material mixing and water adding are decocted 3 times, filtrate and above-mentioned volatile oil aqueous extract merge, and are concentrated into the clear paste of relative density 1.10～1.14, and alcohol is sink to relative density 1.25～1.30, drying under reduced pressure is ground into fine powder to doing;
The beta-cyclo dextrin included compound fine powder of above-mentioned Rhizoma Acori Graminei volatile oil, above-mentioned water extract fine powder are mixed with dextrin, add ethanol and make granule, drying, packing is promptly.
4, according to the preparation method of the medicine of the described Cure for insomnia of claim 3, it is characterized in that: the extraction process of described volatile oil is that Rhizoma Acori Graminei adds 6 times of amounts of water and soaked 2 hours, extracts volatile oil 8 hours.
5, according to the preparation method of the medicine of the described Cure for insomnia of claim 3, it is characterized in that: described water extraction decocts with water three times amount of water and is respectively 10 times, 8 times and 8 times, and extraction time was respectively 1 hour, 1 hour and 0.5 hour.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02144939 CN1201775C (en) | 2002-12-18 | 2002-12-18 | Medicine for treating insomnia-sleeping particle and preparation thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02144939 CN1201775C (en) | 2002-12-18 | 2002-12-18 | Medicine for treating insomnia-sleeping particle and preparation thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1424073A CN1424073A (en) | 2003-06-18 |
| CN1201775C true CN1201775C (en) | 2005-05-18 |
Family
ID=4750718
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 02144939 Expired - Fee Related CN1201775C (en) | 2002-12-18 | 2002-12-18 | Medicine for treating insomnia-sleeping particle and preparation thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1201775C (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1895520B (en) * | 2006-06-22 | 2011-06-29 | 博安兄弟制药（中国）有限公司 | Gastrin magnesium granules and preparation thereof |
| CN115363122A (en) * | 2022-07-12 | 2022-11-22 | 宁波大学科学技术学院 | Health-preserving gardenia tea for treating insomnia and tea bag |
-
2002
- 2002-12-18 CN CN 02144939 patent/CN1201775C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1424073A (en) | 2003-06-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101711810B (en) | Preparation used for improving sleep and enhancing immunity | |
| CN1840166A (en) | Modern Chinese medicinal oral liquid of 'Wen Dan Tang' and preparation method thereof | |
| CN101053621A (en) | Traditional Chinese medicinal composition for treating obesity and its preparation method | |
| CN102228617B (en) | Medicinal composition for treating insomnia | |
| CN100502918C (en) | Insomnia-treating medicament and method for preparing same | |
| CN1201775C (en) | Medicine for treating insomnia-sleeping particle and preparation thereof | |
| CN115487239A (en) | Pharmaceutical composition for treating insomnia with anxiety and depression and preparation method thereof | |
| CN100479837C (en) | Weinakang for treating ischemic cerebrovascular disease and senile dementia and preparation method thereof | |
| CN110538232B (en) | Anti-depression compound preparation and preparation method thereof | |
| CN1565524A (en) | Medicine for treating senile dementia and its preparing process | |
| CN103656164A (en) | Traditional Chinese medicine composition for nourishing yin, nourishing blood, tonifying heart and soothing nerves and preparation method thereof | |
| CN102631397A (en) | Traditional Chinese medicine composition for improving cerebral blood circulation and preparation method thereof | |
| CN1843437A (en) | Medicinal composition for treating insomnia and its preparing process | |
| CN101559139A (en) | Prescription of pure traditional Chinese medicine preparation for preventing and curing neurasthenia insomnia and preparation method thereof | |
| CN1695715A (en) | Medication for treating dementia in blood vessel type, and preparation method | |
| CN1973850A (en) | Medicine composition for treating allergic rhinitis and its prepn process | |
| CN1270737C (en) | Drug for treating gout and method for preparing pill thereof | |
| CN1150839C (en) | Health food with blood pressure and blood lipoid regulating function and its production process | |
| CN104623352B (en) | A kind of pharmaceutical composition for improving sleep | |
| CN101390941B (en) | Use of medicine composition in preparing medicine for treating insomnia | |
| CN1544047A (en) | Chinese traditional medicine composition for treating cancer and its preparation | |
| CN1672722A (en) | Heart-nourishing and tranquilizing medicine and its prepn process | |
| CN1446554A (en) | Medicine for treating acute cholecystitis and chronic cholecystitis and its preparing method | |
| CN1152701C (en) | Kidney-benefiting and tranquilizing medicine and its prepn | |
| CN1931256A (en) | Chinese medicine capsule for eliminating drug addiction and its prepn process |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20050518 Termination date: 20121218 |