CN1200742C - 用于输注用途的系统和组合物 - Google Patents

用于输注用途的系统和组合物 Download PDF

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Publication number
CN1200742C
CN1200742C CNB008060290A CN00806029A CN1200742C CN 1200742 C CN1200742 C CN 1200742C CN B008060290 A CNB008060290 A CN B008060290A CN 00806029 A CN00806029 A CN 00806029A CN 1200742 C CN1200742 C CN 1200742C
Authority
CN
China
Prior art keywords
solution
blood
usually
plasma
liquid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB008060290A
Other languages
English (en)
Chinese (zh)
Other versions
CN1346286A (zh
Inventor
P·E·泽加尔
H·D·巍茨
H·斯滕伯格
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lineage Cell Therapeutics Inc
Original Assignee
Biotime Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biotime Inc filed Critical Biotime Inc
Publication of CN1346286A publication Critical patent/CN1346286A/zh
Application granted granted Critical
Publication of CN1200742C publication Critical patent/CN1200742C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/12—Chemical aspects of preservation
    • A01N1/122—Preservation or perfusion media
    • A01N1/126—Physiologically active agents, e.g. antioxidants or nutrients
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/718—Starch or degraded starch, e.g. amylose, amylopectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Dentistry (AREA)
  • Environmental Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Inorganic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • External Artificial Organs (AREA)
CNB008060290A 1999-02-03 2000-01-24 用于输注用途的系统和组合物 Expired - Fee Related CN1200742C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/243,921 1999-02-03
US09/243,921 US6589223B1 (en) 1999-02-03 1999-02-03 Method and compositions for use in perfusion applications

Publications (2)

Publication Number Publication Date
CN1346286A CN1346286A (zh) 2002-04-24
CN1200742C true CN1200742C (zh) 2005-05-11

Family

ID=22920663

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB008060290A Expired - Fee Related CN1200742C (zh) 1999-02-03 2000-01-24 用于输注用途的系统和组合物

Country Status (14)

Country Link
US (3) US6589223B1 (cg-RX-API-DMAC7.html)
EP (1) EP1150728A4 (cg-RX-API-DMAC7.html)
JP (2) JP2002536078A (cg-RX-API-DMAC7.html)
CN (1) CN1200742C (cg-RX-API-DMAC7.html)
AR (1) AR022482A1 (cg-RX-API-DMAC7.html)
AU (1) AU765144B2 (cg-RX-API-DMAC7.html)
BR (1) BR0008006A (cg-RX-API-DMAC7.html)
CA (1) CA2362051C (cg-RX-API-DMAC7.html)
EA (1) EA003171B1 (cg-RX-API-DMAC7.html)
IL (1) IL144710A0 (cg-RX-API-DMAC7.html)
MX (1) MXPA01007875A (cg-RX-API-DMAC7.html)
TW (1) TW542728B (cg-RX-API-DMAC7.html)
WO (1) WO2000045873A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA200107243B (cg-RX-API-DMAC7.html)

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US8409846B2 (en) 1997-09-23 2013-04-02 The United States Of America As Represented By The Department Of Veteran Affairs Compositions, methods and devices for maintaining an organ
US6589223B1 (en) * 1999-02-03 2003-07-08 Biotime, Inc. Method and compositions for use in perfusion applications
US6718735B2 (en) * 2002-03-19 2004-04-13 Baxter International Inc. Albumin in a flexible polymeric container
US7354342B2 (en) * 2003-07-30 2008-04-08 Igt Gaming device having a multiple coordinate award distributor including award percentages
US8304181B2 (en) 2004-10-07 2012-11-06 Transmedics, Inc. Method for ex-vivo organ care and for using lactate as an indication of donor organ status
US9301519B2 (en) * 2004-10-07 2016-04-05 Transmedics, Inc. Systems and methods for ex-vivo organ care
US12010987B2 (en) 2004-10-07 2024-06-18 Transmedics, Inc. Systems and methods for ex-vivo organ care and for using lactate as an indication of donor organ status
US8585380B2 (en) 2004-10-07 2013-11-19 Transmedics, Inc. Systems and methods for ex-vivo organ care
US20100121273A1 (en) * 2005-06-22 2010-05-13 Kochanek Patrick M Emergency preservation and resuscitation methods
US9078428B2 (en) 2005-06-28 2015-07-14 Transmedics, Inc. Systems, methods, compositions and solutions for perfusing an organ
US7712094B2 (en) * 2005-12-22 2010-05-04 Alan Joshua Shapiro Method and apparatus for replicating a panoplex onto a storage medium from a master
DK1942726T3 (en) * 2006-04-19 2017-04-10 Transmedics Inc METHODS FOR EX VIVO ORGANIC CARE
US9457179B2 (en) 2007-03-20 2016-10-04 Transmedics, Inc. Systems for monitoring and applying electrical currents in an organ perfusion system
KR101183965B1 (ko) * 2007-10-05 2012-09-18 후소 야쿠힝 고교 가부시끼가이샤 안정한 탄산수소 이온 함유 약액
US20090123436A1 (en) * 2007-11-08 2009-05-14 Surmodics, Inc. Cryopreservative compositions and methods
US9247728B2 (en) 2008-01-31 2016-02-02 Transmedics, Inc. Systems and methods for ex vivo lung care
SE534527C2 (sv) * 2009-09-24 2011-09-20 Vivoline Medical Ab Förfarande, anordning och vätska för behandling av ett hjärta efter uttagning
DK4032401T3 (da) 2011-04-14 2025-12-15 Transmedics Inc Fremgangsmåde til fremstilling af en organplejeopløsning til maskinperfusion ex-vivo af donorlunger
US8579880B2 (en) * 2012-03-01 2013-11-12 Outcome Solutions, Llc Devices and methods for making and administering an intravenous liquid with supersaturated dissolved gas
IL303658B2 (en) 2014-06-02 2024-07-01 Transmedics Inc Ex vivo organ care system
DK3229588T3 (da) 2014-12-12 2025-06-23 Transmedics Inc Anordning og fremgangsmåde til organperfusion
DK3347084T3 (da) 2015-09-09 2021-02-15 Transmedics Inc Aortakanyle til ex vivo-organplejesystem
DK3462861T5 (da) 2016-05-30 2024-01-08 Transmedics Inc Fremgangsmåde til ex vivo-lungeventilati on med et varierende udvendigt tryk

Family Cites Families (27)

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US3677024A (en) 1970-01-20 1972-07-18 Paul E Segall Preservation and storage of biologic materials
US3937821A (en) 1971-08-21 1976-02-10 Kyorin Seiyaku Kabushiki Kaisha Plasma substitute including artificial starch and method for the preparation thereof
US4001401A (en) 1975-02-02 1977-01-04 Alza Corporation Blood substitute and blood plasma expander comprising polyhemoglobin
US4061736A (en) 1975-02-02 1977-12-06 Alza Corporation Pharmaceutically acceptable intramolecularly cross-linked, stromal-free hemoglobin
DE2801123C2 (de) 1977-01-26 1986-01-02 Armour Pharma GmbH & Co KG, 3440 Eschwege Verfahren zur Herstellung eines intravenös applizierbaren Serumeiweiß-Präparates
EP0185759B2 (en) 1984-06-22 2004-06-02 Btg International Limited Electrolyte solutions and (in vivo) use thereof
US5084377A (en) 1984-09-19 1992-01-28 Larry Rowan Cryogenic suspension method
US4908350A (en) 1985-10-31 1990-03-13 The Regents Of The University Of California Hyperosmotic/hyperoncotic solutions for resuscitation of hypodynamic shock
US5210083A (en) 1986-07-17 1993-05-11 Ed. Geistlich Sohne A.G. Fur Chemische Industrie Pharmaceutical compositions
JPS6360931A (ja) 1986-08-29 1988-03-17 Noboru Sato 血液または血液製剤保存液およびこれを用いた血液または血液製剤の保存方法
US4927806A (en) 1987-04-23 1990-05-22 The Regents Of The University Of California Saturated salt/concentrated dextran formulation to treat hemorrhage
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US5130230A (en) * 1988-05-02 1992-07-14 Cryomedical Sciences, Inc. Blood substitute
US4923442A (en) * 1988-05-02 1990-05-08 Cryomedical Sciences Inc. Blood substitute
USRE34077E (en) * 1988-05-02 1992-09-22 Cryomedical Sciences, Inc. Blood substitute
US5082831A (en) 1989-12-05 1992-01-21 Cryovita Laboratories, Inc. Total body washout solution and method of use
US5171526A (en) 1990-01-05 1992-12-15 Allergan, Inc. Ophthalmic compositions and methods for preserving and using same
CA2066374C (en) 1991-04-19 2002-01-29 Paul E. Segall Solution for perfusing primates
EP0663821A4 (en) 1991-08-08 1997-09-17 Leigh D Segel BLOOD SUBSTITUTE WITH FLUOROCARBON.
US5334142A (en) * 1991-09-09 1994-08-02 New York University Selective aortic perfusion system
US5374428A (en) * 1993-03-23 1994-12-20 Kansas State University Research Foundation Supplementation of protein diets with di- and tripeptides
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CN1102851C (zh) * 1993-06-04 2003-03-12 生物时间公司 类血浆溶液
US5405742A (en) * 1993-07-16 1995-04-11 Cyromedical Sciences, Inc. Solutions for tissue preservation and bloodless surgery and methods using same
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US6589223B1 (en) * 1999-02-03 2003-07-08 Biotime, Inc. Method and compositions for use in perfusion applications

Also Published As

Publication number Publication date
CA2362051A1 (en) 2000-08-10
AU3349700A (en) 2000-08-25
EP1150728A4 (en) 2004-09-29
EA200100855A1 (ru) 2002-02-28
JP2002536078A (ja) 2002-10-29
BR0008006A (pt) 2001-12-04
MXPA01007875A (es) 2002-08-20
JP5180912B2 (ja) 2013-04-10
TW542728B (en) 2003-07-21
US7503913B2 (en) 2009-03-17
JP2009242404A (ja) 2009-10-22
AU765144B2 (en) 2003-09-11
AR022482A1 (es) 2002-09-04
IL144710A0 (en) 2002-06-30
CN1346286A (zh) 2002-04-24
EA003171B1 (ru) 2003-02-27
US20040018966A1 (en) 2004-01-29
US6589223B1 (en) 2003-07-08
ZA200107243B (en) 2002-09-02
US20060088606A1 (en) 2006-04-27
WO2000045873A1 (en) 2000-08-10
EP1150728A1 (en) 2001-11-07
US6991624B2 (en) 2006-01-31
CA2362051C (en) 2010-06-29

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Legal Events

Date Code Title Description
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C06 Publication
PB01 Publication
C14 Grant of patent or utility model
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20050511

Termination date: 20190124