CN1199981C - Zinc scutellarin as a new medicine - Google Patents
Zinc scutellarin as a new medicine Download PDFInfo
- Publication number
- CN1199981C CN1199981C CN 99114810 CN99114810A CN1199981C CN 1199981 C CN1199981 C CN 1199981C CN 99114810 CN99114810 CN 99114810 CN 99114810 A CN99114810 A CN 99114810A CN 1199981 C CN1199981 C CN 1199981C
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- CN
- China
- Prior art keywords
- zinc
- medicine
- scutellarin
- baicaline
- znba
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Abstract
The present invention relates to zinc scutellarin as a new medicine, which belongs to a medicine, particularly to a new medicine synthesized from scutellarin used as a ligand, and microelement zinc used as a central atom. The zinc scutellarin is specifically prepared by the reaction of a zinc salt with scutellarin. The zinc scutellarin can enhance the therapeutic effect of scutellaria as a traditional Chinese medicine, increase bioactivity, reduce toxic and side effect, and convert a traditional Chinese medicine to be in the form of a western medicine.
Description
Technical field
The invention belongs to medicine, particularly with baicaline as part, trace element zinc is as central atom synthetic medicine.
Technical background
Though the Chinese herbal treatment disease has good effect, from numerous medicines, find out and extract effective ingredient by research, therefrom filter out the compound that biological activity is strong, toxic side effect is little again, this is very difficult.Baicaline is the effective ingredient in the root of large-flowered skullcap, but it only has the effect of antisepsis and anti-inflammation, and clinical application range is narrower.
Summary of the invention
Technical problem to be solved by this invention provides a kind of medicine that makes with the effective ingredient of herbal medicine, particularly baicaline reacts the synthetic medicine with trace element, this medicine is by changing the molecular structure of baicaline, thereby reach obvious raising curative effect, increase biological activity, reduce toxic side effect, initiative is than natural product better medicament.
Solving the scheme that technical problem of the present invention adopts is: as part, trace element zinc generates ZnBA as central atom by zinc salt and baicaline reaction with baicaline, and its molecular weight is 632.38, and chemical structural formula is:
In the reaction of chemosynthesis said medicine, zinc salt can adopt zinc acetate, zinc chloride or zinc sulfate, and baicaline can extract from baikal skullcap root, and its purity can be more than 95%, and the pH value of baicaline lysate is between 6.5～7.0 during reaction.
Embodiment
Below, provide two specific embodiments that make this medicine, so that it is further described.
Embodiment 1: with baikal skullcap root (Scutellaria baicalensis, S.amoena, S.likiangensis) make the baicaline of purity more than 95% for raw material, the distilled water that adds 5 times of amounts makes its suspendible, heating in water bath, slowly add 1% sodium hydroxide, baicaline is all dissolved, and this moment, the pH value of solution was 6.5～7.0, dripped the saturated acetic acid zinc solution, produce a large amount of orange precipitations this moment, when adding last zinc acetate solution, do not have till the precipitation generation.Heating in water bath 20 minutes was placed 30 minutes, filters, and collecting precipitation, washing is washed till till the no zine ion, and 60 ℃ of dryings obtain ZnBA.
Embodiment 2: with baikal skullcap root (Scutellaria baicalensis, S.amoena, S.likiangensis) make the baicaline of purity more than 95% for raw material, get 0.45 gram and be dissolved in 50 milliliter 50% methyl alcohol, the dissolving back adds 20% sodium hydroxide accent pH value to 6.5～7.0, takes by weighing 0.22 gram zinc acetate again and is dissolved in 30 milliliter 50% methyl alcohol, while stirring it is splashed in the above-mentioned baicaline solution, stirred 30 minutes, refluxed 4 hours, produce a large amount of orange precipitations.Filter, collecting precipitation, distilled water wash be not till have a zine ion, and 60 ℃ of dryings obtain ZnBA.
The check of zine ion: get a washing lotion, add one 1% K
3(Fe (CN)
6), do not generate if there is precipitation, can think and not have zine ion in the washing lotion.
Clinical application: get 4.5～5 gram Xylo-Mucines and add soaked overnight in 150 ml distilled waters, heating in water bath, add each 1 gram of glycerine and TW-80, stir, add 0.5 this medicine of gram, stir, on sheet glass, launch film forming, make per 1 square centimeter film contain 1 milligram of this medicine, 70 ℃～80 ℃ dryings obtain the medicine film.This medicine film is used for the treatment of example surplus the stomatocace 600, efficient 94%, do not find side effect; Treatment cervical erosion 22 examples, efficient 92%, do not find side effect; Hemorrhage, ulcer 30 examples of treatment nasal mucosa, curative ratio 100% is not found side effect; Example surplus treatment laryngitis, the pharyngitis 30, efficient 98%, do not find side effect.Prove that from clinical observation this curative effect of medication is remarkable, have no side effect, have good hemostasis, pain relieving, antibiotic, repair effect such as mucosal tissue.
Claims (2)
1, a kind of medicine ZnBA is characterized in that with baicaline as part, and trace element zinc forms the synthetic drug of coordination compound as central atom, and molecular weight is 632.38, and the molecular structure of chemistry formula is:
2, by the described medicine ZnBA of claim 1, the zinc salt that it is characterized in that synthetic drugs can adopt zinc acetate, zinc chloride or zinc sulfate, baicaline is to extract in the baikal skullcap root, and its purity can be more than 95%, and the pH value of baicaline lysate is 6.5～7.0 during reaction.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 99114810 CN1199981C (en) | 1998-04-28 | 1999-04-19 | Zinc scutellarin as a new medicine |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN98108117 | 1998-04-28 | ||
| CN98108117.7 | 1998-04-28 | ||
| CN 99114810 CN1199981C (en) | 1998-04-28 | 1999-04-19 | Zinc scutellarin as a new medicine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1244533A CN1244533A (en) | 2000-02-16 |
| CN1199981C true CN1199981C (en) | 2005-05-04 |
Family
ID=25744651
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 99114810 Expired - Lifetime CN1199981C (en) | 1998-04-28 | 1999-04-19 | Zinc scutellarin as a new medicine |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1199981C (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1299693C (en) * | 2005-05-20 | 2007-02-14 | 昆明医学院 | Method for preparing aqueous solution of complex of baicalin zinc |
| CN102516341B (en) * | 2011-11-16 | 2014-04-09 | 西南大学 | Baicalin metal complex and preparation method and application thereof |
| CN104725408B (en) * | 2015-04-13 | 2016-08-24 | 安徽中升药业有限公司 | One coordination scutelloside Zn complex and preparation method thereof |
| US9908835B2 (en) | 2015-11-13 | 2018-03-06 | Celanese International Corporation | Processes for purifying acetic and hydrating anhydride |
| CN108659082B (en) * | 2018-05-25 | 2021-09-24 | 武汉轻工大学 | Preparation method of baicalin zinc complex for treating piglet diarrhea |
| CN109970800A (en) * | 2019-04-29 | 2019-07-05 | 武汉轻工大学 | A kind of bismuth-scutelloside complex and its preparation method and application |
-
1999
- 1999-04-19 CN CN 99114810 patent/CN1199981C/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CN1244533A (en) | 2000-02-16 |
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| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CX01 | Expiry of patent term | ||
| CX01 | Expiry of patent term |
Granted publication date: 20050504 |