CN1695631A - Method for preparing aqueous solution of complex of baicalin zinc - Google Patents
Method for preparing aqueous solution of complex of baicalin zinc Download PDFInfo
- Publication number
- CN1695631A CN1695631A CN 200510010818 CN200510010818A CN1695631A CN 1695631 A CN1695631 A CN 1695631A CN 200510010818 CN200510010818 CN 200510010818 CN 200510010818 A CN200510010818 A CN 200510010818A CN 1695631 A CN1695631 A CN 1695631A
- Authority
- CN
- China
- Prior art keywords
- baicalin
- znba
- aqueous solution
- complex
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
A medical aqueous (or alcoholic) solution of baicalin zinc complex is prepared through dissolving the baicalin zinc in the alkali solution of sodium hydroxide (or carbonate), and regulating pH value by hydrochloric acid or acetic acid.
Description
Affiliated technical field
The invention belongs to and prepare the medical solutions that complex of baicalin zinc is arranged.
Background technology
The product of baicalin and zinc ion complexation abbreviates Baicalin-Zn BA-Zn ZnBA as, contains the acetate group in the molecular structure, is acidic materials.Solubility test in water and ethyl acetate shows to Baicalin-Zn BA-Zn ZnBA, the water solublity of Baicalin-Zn BA-Zn ZnBA and fat-soluble all less.Number of patent application is 99114810.X, and a kind of new drug Baicalin-Zn BA-Zn ZnBA, this material are brown powder, water insoluble or ethanol.If use, need the sodium carboxymethyl cellulose heating in water bath, add glycerol and TW80 again, add Baicalin-Zn BA-Zn ZnBA and evenly stir, on glass plate, launch film forming, 70～80 ℃ of dryings obtain the medicine film.Not easy to use in clinical practice.Therefore, also must make the aqueous solution or the alcoholic solution that keep its effective organic principle with the Baicalin-Zn BA-Zn ZnBA power applications in industries such as medicine or food.
Summary of the invention
The objective of the invention is under the prerequisite of not destroying the original molecule structure, preparation Baicalin-Zn BA-Zn ZnBA high concentration solution or ethanol water make its more convenient industries such as medicine or food that are used for.
For achieving the above object, the present invention gets Baicalin-Zn BA-Zn ZnBA and places an amount of pure water or ethanol to continue to stir, and slowly adds alkaline solution simultaneously and reacts, and Baicalin-Zn BA-Zn ZnBA dissolving pH value is about 10.0～10.5; Get acid solution again, under vigorous stirring, slowly add in the above solution, in the time of between question response thing pH value is about 6.0～7.0, be settled to desired concn, add pure water.Described Baicalin-Zn BA-Zn ZnBA and an amount of pure water or ethanol heating in water bath to 60～70 ℃, pH value is between 4～5.5.Described alkaline solution can adopt sodium hydroxide or sodium carbonate liquor.Described acid solution can adopt hydrochloric acid or acetum.
According to this law prepared solution outward appearance clarification, transparent, ambient stable.The aqueous solution or the alcoholic solution of available PH＞6.0 dilute arbitrarily.The present invention has changed the limitation of present Baicalin-Zn BA-Zn ZnBA in clinical use, is convenient to sector applications such as medicine or food.
The specific embodiment
The present invention will be further described by the following examples.
Embodiment 1:
Take by weighing Baicalin-Zn BA-Zn ZnBA 1.0g and add pure water 37.0ml and stir in the 100ml beaker, pH value is 5.5, is heated to 60 ℃; Continue to stir, dropwise add 2N NaOH aqueous solution 1.4ml, Baicalin-Zn BA-Zn ZnBA dissolves gradually, and dissolving back pH value is 10.1 fully, is cooled to room temperature; Get 2N HCl 0.4ml, dropwise add beaker under the vigorous stirring, pH value is 7.2, does not have suspendible and precipitate.Again liquor capacity is settled to 50ml, adds pure water.This solution is that concentration is 2% Baicalin-Zn BA-Zn ZnBA aqueous solution.The outward appearance dark brown, clarification, transparent, viscosity is bigger.
This scheme can prepare 5% with Baicalin-Zn BA-Zn ZnBA aqueous solution interior or that concentration is higher.
Embodiment 2:
Take by weighing Baicalin-Zn BA-Zn ZnBA 5.0g, add in the 100ml beaker with dehydrated alcohol 25ml and pure water 12ml and stir, pH value is 4.0, is heated to 60 ℃.Get 2N NaOH aqueous solution 6.9ml, continue to stir, dropwise add in the beaker, Baicalin-Zn BA-Zn ZnBA dissolves gradually, and dissolving back pH value is 10.4 fully, is cooled to room temperature.Get 2N HCl 2.0ml, dropwise add in the beaker under the vigorous stirring, making pH value is 7.2.Liquor capacity is settled to 50ml, adds pure water.This is that baicalin concentration is 10%, and volumetric ratio is 50% alcoholic solution.The outward appearance dark brown, clarification, transparent, viscosity is less.
Adjust the solution that the ethanol proportion can prepare different volumetric ratios in this scheme.Adjust the Baicalin-Zn BA-Zn ZnBA ratio and can prepare 10% above concentration Baicalin-Zn BA-Zn ZnBA alcoholic solution.
Embodiment 3:
Take by weighing Baicalin-Zn BA-Zn ZnBA 1.0g and add pure water 35ml and stir in the 100ml beaker, pH value is 5.0.Get 2MNaCO aqueous solution 6.9ml, dropwise add in the beaker, continue to stir, Baicalin-Zn BA-Zn ZnBA dissolves gradually, and dissolving back pH value is 10.2 fully, and consumption is about 3.2ml.Get 2N HAc, add dropwise under the vigorous stirring that pH value is 7.0 in the beaker, 2N HAc consumption is about 3.5ml.Add pure water, liquor capacity is settled to 50ml.This is that concentration is 2% Baicalin-Zn BA-Zn ZnBA aqueous solution.The outward appearance dark brown, clarification, transparent, viscosity is bigger.
This scheme can prepare 5% with Baicalin-Zn BA-Zn ZnBA aqueous solution interior or that concentration is higher.
Claims (4)
1, a kind of preparation method of aqueous solution of complex of baicalin zinc is characterized in that getting Baicalin-Zn BA-Zn ZnBA and places an amount of pure water or ethanol to continue to stir, and slowly adds alkaline solution simultaneously and reacts, and Baicalin-Zn BA-Zn ZnBA dissolving pH value is about 10.0～10.5; Get acid solution again, under vigorous stirring, slowly add in the above solution, in the time of between question response thing pH value is about 6.0～7.0, be settled to desired concn, add pure water.
2, the preparation method of a kind of aqueous solution of complex of baicalin zinc according to claim 1 is characterized in that Baicalin-Zn BA-Zn ZnBA heating in water bath to 60～70 ℃ in an amount of pure water or ethanol, and pH value is 4～5.5.
3, the preparation method of a kind of aqueous solution of complex of baicalin zinc according to claim 1 is characterized in that alkaline solution is sodium hydroxide or sodium carbonate liquor.
4, the preparation method of a kind of aqueous solution of complex of baicalin zinc according to claim 1 is characterized in that acid solution is hydrochloric acid or acetum.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100108182A CN1299693C (en) | 2005-05-20 | 2005-05-20 | Method for preparing aqueous solution of complex of baicalin zinc |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100108182A CN1299693C (en) | 2005-05-20 | 2005-05-20 | Method for preparing aqueous solution of complex of baicalin zinc |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1695631A true CN1695631A (en) | 2005-11-16 |
| CN1299693C CN1299693C (en) | 2007-02-14 |
Family
ID=35348620
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2005100108182A Expired - Fee Related CN1299693C (en) | 2005-05-20 | 2005-05-20 | Method for preparing aqueous solution of complex of baicalin zinc |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1299693C (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102516341A (en) * | 2011-11-16 | 2012-06-27 | 西南大学 | Baicalin metal complex and preparation method and application thereof |
| CN108659082A (en) * | 2018-05-25 | 2018-10-16 | 武汉轻工大学 | A kind of preparation method for treating grice diarrhoea scutelloside Zn complex |
| CN111000896A (en) * | 2019-12-30 | 2020-04-14 | 武汉回盛生物科技股份有限公司 | Method for preparing baicalein metal complex by ore coagulation method and preparation thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1199981C (en) * | 1998-04-28 | 2005-05-04 | 蔡传英 | Zinc scutellarin as a new medicine |
| CN1189178C (en) * | 2002-05-28 | 2005-02-16 | 昆明贵金属研究所 | Medicine use of cooperation substance of zinc glycoside of baikal skullcap root |
-
2005
- 2005-05-20 CN CNB2005100108182A patent/CN1299693C/en not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102516341A (en) * | 2011-11-16 | 2012-06-27 | 西南大学 | Baicalin metal complex and preparation method and application thereof |
| CN102516341B (en) * | 2011-11-16 | 2014-04-09 | 西南大学 | Baicalin metal complex and preparation method and application thereof |
| CN108659082A (en) * | 2018-05-25 | 2018-10-16 | 武汉轻工大学 | A kind of preparation method for treating grice diarrhoea scutelloside Zn complex |
| CN108659082B (en) * | 2018-05-25 | 2021-09-24 | 武汉轻工大学 | Preparation method of baicalin zinc complex for treating piglet diarrhea |
| CN111000896A (en) * | 2019-12-30 | 2020-04-14 | 武汉回盛生物科技股份有限公司 | Method for preparing baicalein metal complex by ore coagulation method and preparation thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1299693C (en) | 2007-02-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN106146913B (en) | A kind of chitosan-based hydrogel and its preparation method and application | |
| Baek et al. | Design and synthesis of novel glycopolythiophene assemblies for colorimetric detection of influenza virus and E. coli | |
| CN101613420B (en) | Preparation method of 2-hydroxypropyltrimethyl ammonium chloride chitosan | |
| CN106106522A (en) | A kind of nano zine oxide carries silver chitosan compound anti-bacteria agent and preparation method thereof | |
| CN101284884A (en) | Preparation method of temperature sensitivity chitosan derivate-hydroxybutyl chitosan | |
| CN108752501B (en) | Organic acid salt-containing chitosan quaternary ammonium salt and preparation method and application thereof | |
| CN101165071A (en) | Clexane and preparation method thereof | |
| CN1299693C (en) | Method for preparing aqueous solution of complex of baicalin zinc | |
| CN104529747B (en) | The purification process of dodecanedioic acid | |
| CN1193044C (en) | Carboxymethyl chitosan, its preparing method and usage | |
| CN102952280A (en) | Hydroxypropyl methylcellulose copolymer for preparing plant capsules and preparation method thereof | |
| Xu et al. | Novel aggregation induced emission materials from natural Helianthus tuberosus, sustainable of inulin for room temperature phosphorescence | |
| CN101139280B (en) | Preparation method of sodium acetate anhydrous | |
| CN108003252B (en) | Enteromorpha polysaccharide carboxymethylation modified product with improved antioxidant activity and preparation method thereof | |
| CN100355790C (en) | Method for preparing transparent zinc hyaluronic acid | |
| CN101942121A (en) | Method for improving viscosity and stability of sodium alga acid | |
| Zhang et al. | Study on the effect of different concentrations of choline glycine ionic liquid-water mixtures on debranched starch butyrylation reaction | |
| CN110511358A (en) | A kind of poly- D-ALPHA-Hydroxypropionic acid glucose copolymer material and its melt polymerization preparation method | |
| CN103120642B (en) | Gel used for skin diseases and preparation method thereof | |
| CN109499582B (en) | Composite oxide mimic enzyme material and preparation method and application thereof | |
| CN1199981C (en) | Zinc scutellarin as a new medicine | |
| CN105685962A (en) | Preparation method of starch-C18 fatty acid compound | |
| CN1931996A (en) | Edible health calcium vinegar | |
| CN1149226C (en) | Preparation method for hyaluronic acid-like chitosan | |
| CN1644589A (en) | Chloro-N-trimethyl chitin hyamine |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20070214 Termination date: 20100520 |