CN1299693C - Method for preparing aqueous solution of complex of baicalin zinc - Google Patents
Method for preparing aqueous solution of complex of baicalin zinc Download PDFInfo
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- CN1299693C CN1299693C CNB2005100108182A CN200510010818A CN1299693C CN 1299693 C CN1299693 C CN 1299693C CN B2005100108182 A CNB2005100108182 A CN B2005100108182A CN 200510010818 A CN200510010818 A CN 200510010818A CN 1299693 C CN1299693 C CN 1299693C
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- baicalin
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- aqueous solution
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- Inorganic Compounds Of Heavy Metals (AREA)
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Abstract
The present invention relates to a preparation method of the aqueous solution of a baicalin-Zn complex, which belongs to a preparation method of a medicine solution containing a baicalin-Zn complex. Indicated by the solubility tests of the baicalin-Zn in water and ethyl acetate, both the water solubility and the fat solubility of baicalin-Zn are small. The method of the present invention aims to prepare the aqueous solution of baicalin-Zn complex with high concentration or the aqueous solution of ethanol under the premise of no destruction of the original molecular structure so as to ensure the prepared solution is conveniently applied to the industry, such as medicine, food, etc. The method of the present invention adopts alkaline substance such as sodium hydroxide or sodium carbonate to dissolve the baicalin-Zn, and then adopts acidic material such as hydrochloric acid or acetic acid to adjust the pH value to a required range. The solution prepared with the method has a clarifying and transparent external appearance and stable normal temperature, and adopts a water solution or an ethanol solution with the pH value of more than 6.0 to dilute the baicalin-Zn at will to prepare a baicalin-Zn solution with the required concentration.
Description
Affiliated technical field
The invention belongs to and prepare the medical solutions that complex of baicalin zinc is arranged.
Background technology
The product of baicalin and zinc ion complexation abbreviates Baicalin-Zn BA-Zn ZnBA as, contains the acetate group in the molecular structure, is acidic materials.Solubility test in water and ethyl acetate shows to Baicalin-Zn BA-Zn ZnBA, the water solublity of Baicalin-Zn BA-Zn ZnBA and fat-soluble all less.Number of patent application is 99114810.X, and a kind of new drug Baicalin-Zn BA-Zn ZnBA, this material are brown powder, water insoluble or ethanol.If use, need the sodium carboxymethyl cellulose heating in water bath, add glycerol and TW80 again, add Baicalin-Zn BA-Zn ZnBA and evenly stir, on glass plate, launch film forming, 70～80 ℃ of dryings obtain the medicine film.Not easy to use in clinical practice.Therefore, also must make the aqueous solution or the alcoholic solution that keep its effective organic principle with the Baicalin-Zn BA-Zn ZnBA power applications in industries such as medicine or food.
Summary of the invention
The objective of the invention is under the prerequisite of not destroying the original molecule structure, preparation Baicalin-Zn BA-Zn ZnBA high concentration solution or ethanol water make its more convenient industries such as medicine or food that are used for.
For achieving the above object, the present invention gets Baicalin-Zn BA-Zn ZnBA and places an amount of pure water or ethanol to continue to stir, and slowly add alkaline solution simultaneously and react, sodium hydroxide commonly used or sodium carbonate liquor, Baicalin-Zn BA-Zn ZnBA dissolving pH value is about 10.0～10.5; Get acid solution again, hydrochloric acid commonly used or acetum slowly add in the above solution under vigorous stirring, in the time of between question response thing pH value is about 6.0～7.0, are settled to desired concn, add pure water.Described Baicalin-Zn BA-Zn ZnBA and an amount of pure water or ethanol heating in water bath to 60～70 ℃, pH value is between 4～5.5.
According to this law prepared solution outward appearance clarification, transparent, ambient stable.The aqueous solution or the alcoholic solution of available PH＞6.0 dilute arbitrarily.The present invention has changed the limitation of present Baicalin-Zn BA-Zn ZnBA in clinical use, is convenient to sector applications such as medicine or food.
The specific embodiment
The present invention will be further described by the following examples.
Embodiment 1:
Take by weighing Baicalin-Zn BA-Zn ZnBA 1.0g and add pure water 37.0ml and stir in the 100ml beaker, pH value is 5.5, is heated to 60 ℃; Continue to stir, dropwise add 2N NaOH aqueous solution 1.4ml, Baicalin-Zn BA-Zn ZnBA dissolves gradually, and dissolving back pH value is 10.1 fully, is cooled to room temperature; Get 2N HCl 0.4ml, dropwise add beaker under the vigorous stirring, pH value is 7.2, does not have suspendible and precipitate.Again liquor capacity is settled to 50ml, adds pure water.This solution is that concentration is 2% Baicalin-Zn BA-Zn ZnBA aqueous solution.The outward appearance dark brown, clarification, transparent, viscosity is bigger.
This scheme can prepare 5% with Baicalin-Zn BA-Zn ZnBA aqueous solution interior or that concentration is higher.
Embodiment 2:
Take by weighing Baicalin-Zn BA-Zn ZnBA 5.0g, add in the 100ml beaker with dehydrated alcohol 25ml and pure water 12ml and stir, pH value is 4.0, is heated to 60 ℃.Get 2N NaOH aqueous solution 6.9ml, continue to stir, dropwise add in the beaker, Baicalin-Zn BA-Zn ZnBA dissolves gradually, and dissolving back pH value is 10.4 fully, is cooled to room temperature.Get 2N HCl 2.0ml, dropwise add in the beaker under the vigorous stirring, making pH value is 7.2.Liquor capacity is settled to 50ml, adds pure water.This is that baicalin concentration is 10%, and volumetric ratio is 50% alcoholic solution.The outward appearance dark brown, clarification, transparent, viscosity is less.
Adjust the solution that the ethanol proportion can prepare different volumetric ratios in this scheme.Adjust the Baicalin-Zn BA-Zn ZnBA ratio and can prepare 10% above concentration Baicalin-Zn BA-Zn ZnBA alcoholic solution.
Embodiment 3:
Take by weighing Baicalin-Zn BA-Zn ZnBA 1.0g and add pure water 35ml and stir in the 100ml beaker, pH value is 5.0.Get 2MNaCO aqueous solution 6.9ml, dropwise add in the beaker, continue to stir, Baicalin-Zn BA-Zn ZnBA dissolves gradually, and dissolving back pH value is 10.2 fully, and consumption is about 3.2ml.Get 2N HAc, add dropwise under the vigorous stirring that pH value is 7.0 in the beaker, 2N HAc consumption is about 3.5ml.Add pure water, liquor capacity is settled to 50ml.This is that concentration is 2% Baicalin-Zn BA-Zn ZnBA aqueous solution.The outward appearance dark brown, clarification, transparent, viscosity is bigger.
This scheme can prepare 5% with Baicalin-Zn BA-Zn ZnBA aqueous solution interior or that concentration is higher.
Claims (2)
1, a kind of preparation method of aqueous solution of complex of baicalin zinc, it is characterized in that getting Baicalin-Zn BA-Zn ZnBA places an amount of pure water or ethanol to continue to stir, slowly add sodium hydroxide or sodium carbonate liquor simultaneously and react, Baicalin-Zn BA-Zn ZnBA dissolving pH value is about 10.0～10.5; Get hydrochloric acid or acetum again, slowly add under vigorous stirring in the above solution, question response thing pH value is settled to desired concn between 6.0～7.0 the time, adds pure water.
2, the preparation method of a kind of aqueous solution of complex of baicalin zinc according to claim 1 is characterized in that Baicalin-Zn BA-Zn ZnBA heating in water bath to 60～70 ℃ in an amount of pure water or ethanol, and pH value is 4～5.5.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100108182A CN1299693C (en) | 2005-05-20 | 2005-05-20 | Method for preparing aqueous solution of complex of baicalin zinc |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100108182A CN1299693C (en) | 2005-05-20 | 2005-05-20 | Method for preparing aqueous solution of complex of baicalin zinc |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1695631A CN1695631A (en) | 2005-11-16 |
| CN1299693C true CN1299693C (en) | 2007-02-14 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNB2005100108182A Expired - Fee Related CN1299693C (en) | 2005-05-20 | 2005-05-20 | Method for preparing aqueous solution of complex of baicalin zinc |
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| Country | Link |
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| CN (1) | CN1299693C (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102516341B (en) * | 2011-11-16 | 2014-04-09 | 西南大学 | Baicalin metal complex and preparation method and application thereof |
| CN108659082B (en) * | 2018-05-25 | 2021-09-24 | 武汉轻工大学 | Preparation method of baicalin zinc complex for treating piglet diarrhea |
| CN111000896A (en) * | 2019-12-30 | 2020-04-14 | 武汉回盛生物科技股份有限公司 | Method for preparing baicalein metal complex by ore coagulation method and preparation thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1244533A (en) * | 1998-04-28 | 2000-02-16 | 蔡传英 | Zinc scutellarin as a new medicine |
| CN1462619A (en) * | 2002-05-28 | 2003-12-24 | 昆明贵金属研究所 | Medicine use of cooperation substance of zinc glycoside of baikal skullcap root |
-
2005
- 2005-05-20 CN CNB2005100108182A patent/CN1299693C/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1244533A (en) * | 1998-04-28 | 2000-02-16 | 蔡传英 | Zinc scutellarin as a new medicine |
| CN1462619A (en) * | 2002-05-28 | 2003-12-24 | 昆明贵金属研究所 | Medicine use of cooperation substance of zinc glycoside of baikal skullcap root |
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| Publication number | Publication date |
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| CN1695631A (en) | 2005-11-16 |
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Granted publication date: 20070214 Termination date: 20100520 |