CN1194739C - Medicine composition for treating cold and cough, and its prepn. method - Google Patents
Medicine composition for treating cold and cough, and its prepn. method Download PDFInfo
- Publication number
- CN1194739C CN1194739C CNB021534632A CN02153463A CN1194739C CN 1194739 C CN1194739 C CN 1194739C CN B021534632 A CNB021534632 A CN B021534632A CN 02153463 A CN02153463 A CN 02153463A CN 1194739 C CN1194739 C CN 1194739C
- Authority
- CN
- China
- Prior art keywords
- parts
- herba
- portions
- cough
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention discloses a medicine composition for treating cold and cough, which is characterized in that the medicine composition for treating cold and cough is prepared from the following parts by weight of raw material medicine: 60 to 180 parts of houttuynia, 60 to 180 parts of balloon flower, 25 to 75 parts of bitter apricot seeds, 50 to 150 parts of chrysanthemum, 60 to 180 parts of mulberry leaves, 25 to 75 parts of catmint, 30 to 90 parts of mint, 60 to 180 parts of reed root, 25 to 75 parts of liquorice, 60 to 180 parts of forsythia and 30 to 90 parts of perilla leaves. The present invention also discloses a preparation method thereof.
Description
The present invention relates to a kind of pharmaceutical composition for the treatment of cold cough and preparation method thereof.
Cough, expectorant fulminant leucorrhagia with yellowish discharge blood, difficult noise made in coughing or vomiting, have heating concurrently, thirsty etc. be heat syndrome cough, mainly, cause body gas, blood, water imbalance, give birth to expectorant and violate due to the lung because of the evil invasion and attack of affection due to external wind and heat poison human body.Lung abscess is many because of the evil malpractice of affection due to external wind and heat poison, causes the hot blood stasis of disease to tie mutually due to the pulmonary.Above-mentioned disease all belongs to calentura, should control it with the medicine of a cold nature.
The object of the invention be to provide a kind of evident in efficacy and have no side effect have to induce sweat and disperse Chinese medicine of clearing away lung-heat to relieve cough effect and preparation method thereof.
Technical solution of the present invention is achieved in that
Bulk drugs as described below:
25～75 parts of 60～180 portions of Semen Armeniacae Amarums of 60～180 parts of Radix Platycodoniss of Herba Houttuyniae
25～75 parts of 60～180 portions of Herba Schizonepetae of 50～150 parts of Folium Mori of Flos Chrysanthemi
25～75 parts in 60～180 portions of Radix Glycyrrhizaes of 30～90 parts of Rhizoma Phragmitiss of Herba Menthae
30～90 parts of 60～180 parts of Folium Perillaes of Fructus Forsythiae
Preparation method is: get Herba Houttuyniae 120g, Herba Schizonepetae 60g and Herba Menthae 60g and carry out vapor distillation, collect distillate and aqueous solution, distillate is standby; Medicinal residues add Radix Platycodonis 120g, Semen Armeniacae Amarum 60g, Flos Chrysanthemi 120g, Folium Mori 120g, Rhizoma Phragmitis 120g, Radix Glycyrrhizae 60g, Fructus Forsythiae 120g and Folium Perillae 60g, mixing decocts with water twice, 1.5 hours for the first time, 1 hour for the second time, collecting decoction, filter, the medicinal liquid merging behind filtrate and the extraction volatile oil is condensed into clear paste, adds ethanol precipitation and reaches 60% to containing the alcohol amount, left standstill 24 hours, and filtered, reclaim ethanol, and continue to be concentrated into and do not have the alcohol flavor, add sucrose 100g and sodium benzoate 3g, boil, leave standstill, filter, add aforementioned distillate, mixing filters, be adjusted to 1000ml with distilled water, stir evenly, fill, promptly.
Through laboratory observation, the result shows that pharmaceutical composition of the present invention does not have obvious influence to normal mouse temperature; Yeast pyrogenicity rat there is the effect of tangible reduction body temperature; Toluene induced mice ear swelling there is not obvious influence; Rat granuloma hamartoplasia there is the obvious suppression effect; Cause that to guinea pig cough due to the citric acid with to ammonia mouse cough has tangible antitussive effect; Staphylococcus aureus, Bacillus proteus, beta hemolytic streptococcus, streptococcus pneumoniae there is the obvious suppression effect, escherichia coli, staphylococcus epidermidis, Candida albicans, hemophilus influenza, gonococcus etc. also there are certain inhibitory action, significant protective effect are arranged infecting beta hemolytic streptococcus and pneumococcal mice; The external cytopathic effect that obvious suppression influenza virus, respiratory syncytial virus, adenovirus type III and herpes simplex virus I-type are arranged, Measles virus also has certain inhibitory action, can delay its CPE; The interior resisting virus experimental result shows, can effectively suppress influenza virus induced mice viral pneumonia.Experimental result shows that medicine of the present invention has to induce sweat and disperses the effect of clearing away lung-heat to relieve cough.The headache, the heating that are used to catch a cold and cause, the treatment of diseases such as watery nasal discharge, cough.
Pharmaceutical composition of the present invention has to induce sweat to be dispersed, effects such as clearing away lung-heat to relieve cough, the headache, the heating that can be used for catching a cold and cause, treatment of conditions such as watery nasal discharge, cough.
Experimental example 1: the antitussive effect that strong aqua ammonia is caused mouse cough
Get body weight 18-22g mice, be divided into 4 groups at random, the blank group is irritated the stomach normal saline, be subjected to the examination group to irritate extract 10g crude drug/kg, 20g crude drug/kg that stomach gives pharmaceutical composition of the present invention respectively, positive controls gives Folium Eriobotryae cough-relieving electuary 2.0g/kg, irritate the long-pending 2ml/100g, successive administration 5 days of being of body of stomach.After the last administration 30 minutes, mice is put in the airtight glass box, quantitatively being sprayed into the strong aqua ammonia aerosol lures and coughs, write down the number of times of coughing in mouse cough incubation period and 3 minutes, the result is subjected to that examination group and the average cough latent period of positive drug control group all prolong more than 25 seconds, the number of times of on average coughing obviously reduces, and shows that this product has obvious antitussive effect to see the following form.
Group dosage number of animals incubation period (second, the cough number of times of X ± SD) (X ± SD)
Matched group 10 50.8 ± 16.1 29.6 ± 5.7
Folium Eriobotryae cough-relieving electuary 2.0g/kg 10 91.5 ± 22.6 23.6 ± 5.3
*
Pharmaceutical composition 20g/kg 10 96.9 of the present invention ± 22.5 18.3 ± 5.9
*
10g/kg 10 75.1±24.9 24.7±6.7
Experimental example 2: phlegm-dispelling functions
1. to the phenol red influence of mice trachea excretion: get body weight 18-22g mice, be subjected to the examination group to irritate extract 10g crude drug/kg, 20g crude drug/kg that stomach gives pharmaceutical composition of the present invention respectively, positive controls gives Folium Eriobotryae cough-relieving electuary 2.0g/kg, the blank group is irritated the stomach normal saline, successive administration 5 days.After the last administration 30 minutes, lumbar injection 0.25% phenol red normal saline solution.After 30 minutes, put to death mice, flushing pulmonary branches trachea is also collected irrigating solution, measures the OD value, and the result shows that pharmaceutical composition of the present invention can significantly increase the phenol red amount of mice trachea excretion, has obvious phlegm-dispelling functions.
2. to the influence of rat capillary tube expectoration amount: rat is divided into 3 groups, after the anesthesia of lumbar injection pentobarbital sodium, cuts cervical region, separates trachea, inserts glass capillary, writes down the amount of sucking-off expectorant in 2 hours.Be subjected to the examination group to irritate extract 5g crude drug/kg, 15g crude drug/kg that stomach gives pharmaceutical composition of the present invention respectively, matched group is irritated the stomach normal saline, irritates the long-pending 2ml/100g that is of body of stomach, continues to observe 2 hours amounts of expectoration, average secretory volume per hour before and after the record administration.The result shows that being tried object height, low dose group all can increase rat trachea expectoration amount, has tangible phlegm-dispelling functions.
Embodiment 1:
Herba Houttuyniae 120g Radix Platycodonis 120g Semen Armeniacae Amarum 50g
Flos Chrysanthemi 100g Folium Mori 120g Herba Schizonepetae 50g
Herba Menthae 60g Rhizoma Phragmitis 120g Radix Glycyrrhizae 50g
Fructus Forsythiae 120g Folium Perillae 60g
Get Herba Houttuyniae, Herba Schizonepetae, Herba Menthae and carry out vapor distillation, collect distillate and aqueous solution, distillate is standby; Medicinal residues add Radix Platycodonis, Semen Armeniacae Amarum, Flos Chrysanthemi, Folium Mori, Rhizoma Phragmitis, Radix Glycyrrhizae, Fructus Forsythiae, Folium Perillae, and mixing decocts with water twice, 1.5 hours for the first time, 1 hour for the second time, collecting decoction, filter, the medicinal liquid merging behind filtrate and the extraction volatile oil is condensed into clear paste, adds ethanol precipitation and reaches 60% to containing the alcohol amount, left standstill 24 hours, and filtered, reclaim ethanol, and continue to be concentrated into and do not have the alcohol flavor, add sucrose 100g and sodium benzoate 3g, boil, leave standstill, filter, add aforementioned distillate, mixing filters, be adjusted to 1000ml with distilled water, stir evenly, fill, promptly.
Embodiment 2:
Herba Houttuyniae 120g Radix Platycodonis 120g Semen Armeniacae Amarum 60g
Flos Chrysanthemi 120g Folium Mori 120g Herba Schizonepetae 60g
Herba Menthae 60g Rhizoma Phragmitis 120g Radix Glycyrrhizae 60g
Fructus Forsythiae 120g Folium Perillae 60g
Get Herba Houttuyniae, Herba Schizonepetae, Herba Menthae and carry out vapor distillation, collect distillate and aqueous solution, distillate is standby; Medicinal residues add Radix Platycodonis, Semen Armeniacae Amarum, Flos Chrysanthemi, Folium Mori, Rhizoma Phragmitis, Radix Glycyrrhizae, Fructus Forsythiae, Folium Perillae, and mixing decocts with water twice, 1.5 hours for the first time, 1 hour for the second time, collecting decoction, filter, the medicinal liquid merging behind filtrate and the extraction volatile oil is condensed into clear paste, adds
Ethanol precipitation reaches 60% to containing the alcohol amount, leaves standstill 24 hours, filters, and reclaims ethanol, and continues to be concentrated into and do not have the alcohol flavor, adds sucrose 100g and sodium benzoate 3g, boil, leave standstill, filter, add aforementioned distillate, mixing, filter, be adjusted to 1000ml, stir evenly with distilled water, fill, promptly.
Claims (3)
1, a kind of pharmaceutical composition for the treatment of cold cough is characterized in that this pharmaceutical composition is to be made by the raw material of following weight portion:
25～75 parts of 60～180 portions of Semen Armeniacae Amarums of 60～180 parts of Radix Platycodoniss of Herba Houttuyniae
25～75 parts of 60～180 portions of Herba Schizonepetae of 50～150 parts of Folium Mori of Flos Chrysanthemi
25～75 parts in 60～180 portions of Radix Glycyrrhizaes of 30～90 parts of Rhizoma Phragmitiss of Herba Menthae
30～90 parts of 60～180 parts of Folium Perillaes of Fructus Forsythiae.
2,, it is characterized in that this pharmaceutical composition is to be made by the raw material of following weight portion according to the pharmaceutical composition of the described treatment cold cough of claim 1:
100 parts of 50 parts of Flos Chrysanthemis of 120 portions of Semen Armeniacae Amarums of 120 parts of Radix Platycodoniss of Herba Houttuyniae
120 parts of 60 parts of Rhizoma Phragmitiss of 50 portions of Herba Menthaes of 120 portions of Herba Schizonepetae of Folium Mori
60 parts of 120 parts of Folium Perillaes of 50 parts of Fructus Forsythiaes of Radix Glycyrrhizae.
3, a kind of preparation of drug combination method for the treatment of cold cough is characterized in that: get Herba Houttuyniae 120g, Herba Schizonepetae 60g and Herba Menthae 60g and carry out vapor distillation, collect distillate and aqueous solution, distillate is standby; Medicinal residues add Radix Platycodonis 120g, Semen Armeniacae Amarum 60g, Flos Chrysanthemi 120g, Folium Mori 120g, Rhizoma Phragmitis 120g, Radix Glycyrrhizae 60g, Fructus Forsythiae 120g and Folium Perillae 60g, mixing decocts with water twice, 1.5 hours for the first time, 1 hour for the second time, collecting decoction, filter, the medicinal liquid merging behind filtrate and the extraction volatile oil is condensed into clear paste, adds ethanol precipitation and reaches 60% to containing the alcohol amount, left standstill 24 hours, and filtered, reclaim ethanol, and continue to be concentrated into and do not have the alcohol flavor, add sucrose 100g and sodium benzoate 3g, boil, leave standstill, filter, add aforementioned distillate, mixing filters, be adjusted to 1000ml with distilled water, stir evenly, fill, promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021534632A CN1194739C (en) | 2002-11-29 | 2002-11-29 | Medicine composition for treating cold and cough, and its prepn. method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021534632A CN1194739C (en) | 2002-11-29 | 2002-11-29 | Medicine composition for treating cold and cough, and its prepn. method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1418688A CN1418688A (en) | 2003-05-21 |
| CN1194739C true CN1194739C (en) | 2005-03-30 |
Family
ID=4752263
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB021534632A Expired - Lifetime CN1194739C (en) | 2002-11-29 | 2002-11-29 | Medicine composition for treating cold and cough, and its prepn. method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1194739C (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102362989A (en) * | 2011-10-03 | 2012-02-29 | 周春根 | Traditional Chinese medicine for treating cough due to wind-heat evil |
| CN103285267A (en) * | 2013-07-02 | 2013-09-11 | 宋宜德 | Drug for treating influenza and preparation method thereof |
| CN103961583A (en) * | 2014-05-23 | 2014-08-06 | 张俊青 | Chinese herbal preparation for treating viral influenza and preparation method thereof |
| CN106309550A (en) * | 2015-06-15 | 2017-01-11 | 陈盼盼 | External use formula for treating various headache diseases |
| CN105031365A (en) * | 2015-08-26 | 2015-11-11 | 唐媚英 | Traditional Chinese medicine for preventing and treating cold and cough and preparation method thereof |
| CN105125703A (en) * | 2015-08-26 | 2015-12-09 | 江伟明 | Medicine for treating cough and preparing method of medicine |
| CN106474314A (en) * | 2015-08-26 | 2017-03-08 | 唐媚英 | A kind of composition of cough and preparation method thereof |
-
2002
- 2002-11-29 CN CNB021534632A patent/CN1194739C/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CN1418688A (en) | 2003-05-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101049424B (en) | Medication for treating infection in respiratory system | |
| CN1194739C (en) | Medicine composition for treating cold and cough, and its prepn. method | |
| CN101040950B (en) | Method of preparing compound Houttuynia cordata dropping pills | |
| CN101152509A (en) | Method of preparing traditional Chinese medicine preparation for treating chronic pharyngitis | |
| CN112972628A (en) | Traditional Chinese medicine composition, preparation thereof, preparation method and application thereof | |
| WO2022134245A1 (en) | Heat-clearing and exterior syndrome-relieving traditional chinese medicine composition and preparation method therefor | |
| CN101045153A (en) | Traditional Chinese medicine for treating cold | |
| CN1187074C (en) | Medicine composite for treating cough | |
| CN1589852A (en) | External use nose drop agent for treating common cold and its preparation method | |
| CN101496836A (en) | Chinese medicinal composition for treating common cold and preparation method thereof | |
| RU2303992C1 (en) | Curative-prophylactic remedy for youngsters of farm animals and method for preventing and treating respiratory diseases in calves due to its application | |
| CN103446564B (en) | Chinese medicine composition of a kind of anti-inflammation and preparation method thereof | |
| CN100473407C (en) | Chinese medical preparation for curing common cold and cough and preparation method thereof | |
| CN112089799A (en) | Compound preparation for treating chicken bronchial embolism and preparation method thereof | |
| CN102626511B (en) | Drug composition used for relieving cough and eliminating phlegm | |
| CN1218733C (en) | Medicine for treating common cold and preparation method | |
| CN1233400C (en) | Fever bringing down formulating for preventing virus and its prepn. method | |
| CN104887929A (en) | Traditional Chinese medicine composition for treating child pertussis | |
| RU2311190C1 (en) | Therapeutical and prophylactic drug for young agricultural animals and a method to prevent and treatment of viral respiratory diseases in calves using it | |
| CN109674854A (en) | A kind of shield pharynx treasure pill and preparation method thereof | |
| CN1263470C (en) | External use nose drops agent for treating common cold and its preparation method | |
| CN101862392B (en) | New pharmaceutical application of cordate houttuynia in thrombus prevention | |
| CN1274327C (en) | Nose drops agent for treating common cold and its preparation method | |
| CN1562214A (en) | Preparation of Chinese traditional medicine for antivirus in the four seasons and preparation method | |
| CN1562180A (en) | Preparation of Chinese traditional medicine for curing cough and preparation method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| ASS | Succession or assignment of patent right |
Owner name: QIYUANYIDE MEDICINES INST., BEIJING Free format text: FORMER OWNER: ZHANG HUIFANG Effective date: 20030812 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20030812 Address after: 100027, Beijing, Chaoyang District, East Third Ring Road, Xin 2, di Yang building, room 10, 1007A Applicant after: Beijing Qi Yuan Yi De Pharmaceuticals Research Center Address before: 100027, Beijing, Chaoyang District, East Third Ring Road, Xin 2, di Yang building, room 10, 1007A Applicant before: Zhang Huifang |
|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: SHANXI HAITIAN PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: QIYUANYIDE MEDICINES INST., BEIJING Effective date: 20060630 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20060630 Address after: 712000 eastern section of Shiji Avenue, Shaanxi, Xianyang Patentee after: Shaanxi Haitian Pharmaceutical Co.,Ltd. Address before: 100027, Beijing, Chaoyang District, East Third Ring Road, Xin 2, di Yang building, room 10, 1007A Patentee before: Beijing Qi Yuan Yi De Pharmaceuticals Research Center |
|
| CX01 | Expiry of patent term |
Granted publication date: 20050330 |
|
| CX01 | Expiry of patent term |