CN1192668A - 血管内的移植片固定模 - Google Patents

血管内的移植片固定模 Download PDF

Info

Publication number
CN1192668A
CN1192668A CN96196048A CN96196048A CN1192668A CN 1192668 A CN1192668 A CN 1192668A CN 96196048 A CN96196048 A CN 96196048A CN 96196048 A CN96196048 A CN 96196048A CN 1192668 A CN1192668 A CN 1192668A
Authority
CN
China
Prior art keywords
polymer
stent
mould section
fixed die
state
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN96196048A
Other languages
English (en)
Inventor
L·樊
M·弗鲁瓦
S·斯泰特策
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boston Scientific Scimed Inc
Original Assignee
Quanam Medical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Quanam Medical Corp filed Critical Quanam Medical Corp
Publication of CN1192668A publication Critical patent/CN1192668A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M29/00—Dilators with or without means for introducing media, e.g. remedies
    • A61M29/02—Dilators made of swellable material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/88—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure the wire-like elements formed as helical or spiral coils
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/88—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure the wire-like elements formed as helical or spiral coils
    • A61F2/885—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure the wire-like elements formed as helical or spiral coils comprising a coil including a plurality of spiral or helical sections with alternate directions around a central axis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/02—Inorganic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/148—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/18—Materials at least partially X-ray or laser opaque
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/10—Balloon catheters
    • A61M25/1027—Making of balloon catheters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
    • A61F2/958—Inflatable balloons for placing stents or stent-grafts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0014—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof using shape memory or superelastic materials, e.g. nitinol
    • A61F2210/0023—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof using shape memory or superelastic materials, e.g. nitinol operated at different temperatures whilst inside or touching the human body, heated or cooled by external energy source or cold supply
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0014—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof using shape memory or superelastic materials, e.g. nitinol
    • A61F2210/0023—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof using shape memory or superelastic materials, e.g. nitinol operated at different temperatures whilst inside or touching the human body, heated or cooled by external energy source or cold supply
    • A61F2210/0033—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof using shape memory or superelastic materials, e.g. nitinol operated at different temperatures whilst inside or touching the human body, heated or cooled by external energy source or cold supply electrically, e.g. heated by resistor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0014—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof using shape memory or superelastic materials, e.g. nitinol
    • A61F2210/0023—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof using shape memory or superelastic materials, e.g. nitinol operated at different temperatures whilst inside or touching the human body, heated or cooled by external energy source or cold supply
    • A61F2210/0042—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof using shape memory or superelastic materials, e.g. nitinol operated at different temperatures whilst inside or touching the human body, heated or cooled by external energy source or cold supply using a fluid, e.g. circulating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0096—Markers and sensors for detecting a position or changes of a position of an implant, e.g. RF sensors, ultrasound markers
    • A61F2250/0098—Markers and sensors for detecting a position or changes of a position of an implant, e.g. RF sensors, ultrasound markers radio-opaque, e.g. radio-opaque markers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/10—Balloon catheters
    • A61M2025/1043—Balloon catheters with special features or adapted for special applications
    • A61M2025/105—Balloon catheters with special features or adapted for special applications having a balloon suitable for drug delivery, e.g. by using holes for delivery, drug coating or membranes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/10—Balloon catheters
    • A61M2025/1043—Balloon catheters with special features or adapted for special applications
    • A61M2025/1075—Balloon catheters with special features or adapted for special applications having a balloon composed of several layers, e.g. by coating or embedding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/10—Balloon catheters
    • A61M2025/1043—Balloon catheters with special features or adapted for special applications
    • A61M2025/1088—Balloon catheters with special features or adapted for special applications having special surface characteristics depending on material properties or added substances, e.g. for reducing friction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/10—Balloon catheters

Landscapes

  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Surgery (AREA)
  • Epidemiology (AREA)
  • Anesthesiology (AREA)
  • Cardiology (AREA)
  • Transplantation (AREA)
  • Hematology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Child & Adolescent Psychology (AREA)
  • Biophysics (AREA)
  • Pulmonology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Materials For Medical Uses (AREA)
  • Media Introduction/Drainage Providing Device (AREA)

Abstract

描述了一种用来安装在气囊导管的囊上送到目标位置处的移植片固定模。该固定模由一系列可膨胀的条状模段所构成,每个模段当暴露于选定的刺激源中时都适合于在闭合的大曲率状态与膨胀的小曲率状态之间运动。

Description

血管内的移植片固定模
发明领域
本发明涉及一种由记忆聚合物制成的移植片固定模，该固定模用来安装在气囊导管上送到脉管中的目标装置。
发明背景
经皮经管腔的血成形术是用于选定的动脉粥样硬化损伤以解除管腔的通道狭窄的一种疗法。虽然血管成形术已经取得广泛的认可，但手术后的突然闭合和再狭窄经常发生。
血管内的移植片固定模常用来以机械的方法阻挡该管腔的突然闭合和再狭窄。这类固定模通常用金属或塑料制成并且各种各样的固定模已经申请和取得了专利。对由形状记忆合金(Schnepp-Pesch的美国专利5354309)和由包括形状记忆聚合物(Froix的美国专利5163952)的聚合物(Hickle的美国专利5139480；Palmaz的美国专利4739762)制成的沿径向膨胀的固定模都已有人作了描述。这些固定模中的某几种固定模的一个缺点是轴向膨胀与径向膨胀一起发生。轴向膨胀使得难于把该固定模制成规定的尺寸并且难于把它正确地放在目标位置上。某些固定模还常常受至膨胀比的限制，它们只能沿径向膨胀2或4倍。
发明概要
一方面，本发明包括一种用来安装在气囊导管的囊上送到脉管中的目标位置处的移植片固定模。该固定模包括一系列可膨胀的条状模段，当暴露于一个选定的刺激源中时，每个模段都适合于在闭合的大曲率状态和膨胀的小曲率状态之间只大体上沿着径向运动。
该固定模的模段沿其偏置的侧面部位连接成阶梯状，使得模段处于其大曲率状态，该固定模适合于在囊上形成一个可变形的圆柱形套筒。当暴露在刺激源中时，在该固定模中的模段就向着其小曲率状态膨胀，直到该运动受到该脉管的壁的限制为止。
在一个实施例中，该固定模模段连接成一个长条形整体带，而在另一个实施例中，该固定模模段连接成一个V形整体带。
最好是，该条状模段由一种记忆聚合物制成，例如一种含甲基丙烯酸酯聚合物或一种丙烯酸酯聚合物。该记忆聚合物也可以是生物可降解的或者可以含有一种治疗剂，以便有控制地把该治疗剂释放在该目标位置。
一般说来，该记忆聚合物可以是热塑性聚合物，交联热塑性聚合物，热塑性共混聚合物，或者交联热塑性共混聚合物。
制成模段的记忆聚合物具有由一个刺激源所激活的聚合物状态转变，该刺激源例如(a)通过聚合物吸收热量；(b)通过聚合物吸附液体；或(c)在一种与聚合物接触的液体中pH值的变化。
在一个较佳实施例中，该记忆聚合物具有热激活聚合物状态转变，这种状态转变包括(a)该聚合物的熔点；(b)该聚合物的玻璃化转变；(c)一种液晶转变；或(d)一种局部模式分子转变。在一个更佳实施例中，该转变是在约25至65℃之间的温度上的玻璃化转变或结晶熔点。
处于其打开的小曲率状态的固定模模段的外径约在0.1毫米至50毫米之间，更好是在0.5毫米与20毫米之间。当暴露在一个刺激源中时，模段从其闭合的大曲率状态向着其膨胀的小曲率状态膨胀。该固定模的膨胀比(即处于膨胀的打开状态的固定模外径与处于闭合的状态的固定模外径之比)在约2-10(对较小的目标脉管而言)与直至500-2000(对较大的目标脉管而言)之间。
另一方面，本发明包括一种用来把一个移植片固定模输送到脉管中的目标位置上的气囊导管装置。该装置包括一个在其一端具有一个能充满液体的囊的气囊导管。
该固定模由一系可膨胀的条状模段所构成，每个模段当暴露于该液体中时都适合于在闭合的大曲率状态与膨胀的小曲率状态之间只大体上沿着径向运动。该模段沿其偏置的侧面部位这样的连接，使得该模段处于其大曲率状态，该固定模适合于在囊上形成一个可变形的圆柱形套筒。当暴露在该液体中时，该固定模中的模段就向着其小曲率状态膨胀，直到该运动受到该脉管的壁的限制为止。
本发明的这些和其他的目的和特征当阅读了下面的发明详述连同参照附图以后将能获得更充分的理解。
附图简述
图1A-1C示出了本发明的移植片固定模的一个实施例，其中图1A示出了该固定模处于其记忆状态，图1B示出了该固定模处于其闭合的大曲率状态，以及图1C示出了该固定模处于其膨胀的小曲率状态；
图2A-2C示出了本发明的移植片固定模的另一个实施例，图中各固定模模段连接成一个V形带，并且其中图2A示出了该固定模处于其记忆状态，图2B示出了该固定模处于其闭合的状态，以及图1C示出了该固定模处于其膨胀状态。
图3A-3C示出了由具体单个平行四边形段的一个长条形成的移植片固定模，其中图3A示出了该固定模处于其记忆状态，图3B示出了该固定模处于其闭合的状态，以及图3示出了该固定模处于其膨胀的状态；
图4A-4D示出了包括用阴影表示的一种不透射线材料的各种移植片固定模；以及
图5A-5C示出了该移植片固定模在血管中的定位方法，其中图5A示出了该固定模紧贴地安装在气囊导管周围，图5B示出了该固定模被提高到其转变温度以向其记忆状态膨胀，以及图5C示出了导管被抽出，而留下该固定模处于其膨胀状态压紧在目标血管的壁上。
发明详述
本发明的移植片固定模用来安装在气囊导管的气囊上送到脉管中的目标位置。具体地说，该固定模用在脉管中防止血管成形手术后的血管再封闭或再狭窄。一般说来，移植片固定模适合用在各种体腔内，例如动脉、胆管、输尿管、面神经管等各种场合。
如在图1A-1C中所见，该固定模是由一系列可膨胀的条状模段所构成的，这在图1A中看得最清楚。移植片固定模10是由一系列的可膨胀的模段(例如模段12，14，16等)构成的一个长条形整体带。图中画出的虚线(例如虚线18)是为了帮助看见这些固定模模段。模段12(它是代表性的)由端面20，22和侧面24，26所限定。
这些模段沿其偏置的侧面部位连接成阶梯状。如果把它们沿左右或上下方向放置，该阶梯状就意味着这些模段可以以这样的方式放置，即一个模段的上侧面(或端面)与一个相邻模段的下侧面(或端面)相连接，以及该相邻模段的上侧面(或端面)又与下一个相邻模段的下侧面(或端面)相连接，等等。例如在图1A中，模段12和14沿侧面26和28相连接，其中侧面26是模段12的上侧面而侧面28是模段14的下侧面。
这些模段沿其偏置的侧面部位以这种阶梯状的方式相连接。模段12，14沿着互相偏置的侧面26，28相连接。
这些固定模模段由一种记忆聚合物制成，该聚合物具有预先选定的记忆状态，这在下面还要描述。如图1A所示，固定模10的记忆状态是一个扁平条，但是，其他几何形状(例如圆筒状)的记忆状态也是可能的。
下面所述的记忆聚合物被制成为具有受选定的刺激源控制的聚合物状态转变的能力。当暴露在该刺激源中时，聚合物转变被激活，从而使该固定模在其闭合的大曲率状态向着其记忆状态运动。该聚合物转变可以通过吸收热量，吸收液体或者在与该聚合物接触的液体中的pH值的变化而被激活。较好是，该转变通过一个热刺激源来激活，其中，该聚合物在一个预先选定的温度，例如在该聚合物的主链或侧链的晶体熔点下(最好在约25-65℃之间)发生转变。该热转变也可以是一个在温度为25-65℃之间的玻璃化转变，一个液晶相(中间相)温度转变，或是一个局部模式的分子转变。
每个条状模段最初通过把聚合物固定模暴露在上述刺激源中的一个刺激源内而被从其记忆状态转变成一个闭合的大曲率状态。例如，可以把模段加热到其玻璃化转变温度或者比该温度稍高的温度，模段在该温度下将变得更易变形和类似橡胶。条状模段中的每个通过被近转变成小直径的高曲率状态，例如通过把模段包绕或卷绕在气囊导管中的气囊区上而处于其闭合状态。
图1B示出了图1A的固定模10处于其闭合的大曲率状态的情况。图1A中的模段12(它是代表性的)通过把聚合物加热至其转变温度或该温度以上，然后把模段端面20，22组合在一起，而处于其闭合状态。处于其闭合状态的模段可以使其端面互相接触如图1B中所示，或者也可以在模段端面之间有一个间隙。当聚合物冷至转变温度以下或刺激源取消时，模段就继续处于其闭合状态。
从图1B中可以看出，当条状模段处于其闭合位置时，该固定模形成了具有大曲率半径的可变形的小直径套筒。如下面将要说明的，处于闭合状态的固定模紧贴地安装在气囊导管的未膨胀气囊上，以便输送到脉管中的一个目标位置。
图1C示出了固定模10的每个条状模段处于膨胀的小曲率状态的情况。这些模段当暴露在如上所述的一个选定的刺激源(例如吸收热量)中时，就从其闭合的大曲率状态转到其打开的小曲率状态。例如，把温度在25-100℃(更好在40-100℃)范围内的盐水或其他适合的液体射入到该导管的气囊中。热量从该液本传递到聚合物固定模上，该聚合物在一个选定的温度上发生了热转变，使得固定模模段变得容易变形并且开始移向其记忆状态。这些模段一直膨胀直到该运动受到脉管壁的限制为止，从而使该固定模处于其打开的小曲率的膨胀直径的状态。当固定模模段从其大曲率状态向其小曲率状态膨胀时，发生了基本上沿径向的运动。如图1C中所示，固定模10具有一个用虚线38表示的纵向轴线。当暴露在刺激源中时，这些模段沿着用箭头40表示的垂直于轴线38的径向膨胀。当固定模膨胀到其小曲的打开状态时，该固定模几乎没有轴向伸长。因此，当固定模膨胀时，该固定模在脉管内很少有或没有横向运动。从而使固定模能方便地展开并且能牢固地设置在目标位置上。
固定模的尺寸(直径和长度)应满足各个具体应用的要求。例如，对于心血管应用来说固定模的长度范围为5毫米至约30毫米。固定模处于其打开状态的直径范围为0.1毫米至50毫米，具体数值根据目标脉管的内径而定。对于较小的体内脉管(例如脑血管)，它具有的内径为约0.1毫米。对于较大的体内脉管(例如主动脉)，它的直径约为30-50毫米，应根据各个体内脉管的尺寸而定。固定模的膨胀比，即处于膨胀的打开状态的固定模的外径与处于闭合状态的固定模的外径之比，约在2至2000之间，具体取决于聚合物，交联键的数量和其他的参数。
根据本发明的一个重要特征，该固定模由形状记忆聚合物制成，该聚合物一般地说来自热塑性聚合物，具体地说来自含甲基丙烯酸酯的聚合物或含丙烯酸酯的聚合物，如美国专利5163952中所描述的那样。此处所使用的热塑性聚合物是指那些通过热量和/或压力的作用能够软化并且具有新的形状的聚合物。这种聚合物可以在不同程度上交联从而可以由于热量而软化但是不会流动。该记忆聚合物还可以是一种生物可降解的聚合物。
这种聚合物的特征在于通过激活聚合物转变，它将力图呈现其记忆状态。激活可以通过该聚合物吸收热量，该聚合物吸收液体而发生，或者在与该聚合物相接触的液体中的pH值的变化而发生。通过在聚合物中加入一种亲水材料(例如N-乙烯基吡咯烷酮)，可使该聚合物配制成能对吸收液体发生反应。把诸如甲基丙烯酸或丙烯酸加入到该聚合物中将使该聚合物具有一种对pH值发生敏感的转变。该聚合物转变可以是一种热激活的转变，其中该聚合物在吸收热量时将发生玻璃化转变或者晶体熔融。
当聚合物对于一个刺激源起反应并且发生了上述转变中的一种转变时，固定模模段就从其闭合的大曲率状态向着其记忆状态膨胀。同样，当聚合物发生这些转变中的一种转变时，固定模模段也可以从其初始的记忆状态转向其闭合的大曲率状态，或者从其打开的小曲率状态转向其闭合状态。
一种典型的含甲基丙烯酸酯的记忆聚合物可以通过以2∶1.5∶1的比例把单体异丁烯酸甲酯，聚甲基丙烯酸乙二醇酯和甲基丙烯酸丁酯相混合而制成的。一种交联剂(例如聚甲基丙烯酸乙二醇酯)和一种热引发剂或紫外线引发剂(例如苯偶甲醚或者偶氮二异丁腈(AIBN))都被添加进该聚合物中并有当聚合进行时对上述成分进行搅拌。这些单体可被聚合成一种聚合物，通过把它们暴露在紫外线光、高能电子、伽玛射线和热量的作用下就可以使其交联，该聚合物可在常规的挤压机中进行挤压以提供一段管状结构或平板。这些单体也可以在一个透明的旋转管中进行聚合以形成一个管状结构。
另一种典型的热塑性聚合物是聚氧化乙烯，这是一种具有晶体熔点约65℃的杂链热塑性物质。聚氧化乙烯能使用多官能的丙烯酸酯或甲基丙烯酸酯(例如三烯丙基异氰脲酸酯)而交联。热塑性共混物也适用于记忆聚合物，例如聚甲基丙烯酸甲酯、聚乙烯、聚己酸内酯或trans-polyoctenamer(Vestenamer)与聚氧化乙烯的共混物。通常在该混合物中，聚氧化乙烯含量在30-70％的范围内。该共混物可使用常规的多官能交联剂进行交联。
然后将聚合物管或平板切成一段通常为约5毫米-30毫米之间的长度。固定模的内径范围为0.05毫米至50毫米，其壁厚(或板厚)约为0.01至0.5毫米，最好为0.05-0.5毫米。
可以理解，固定模的原始的形状(管形或平板形)就是固定模模段的预先选定的记忆状态。即，当聚合物发生一个选定的转变时，该聚合物将恢复到其记忆状态，这在下面还将详细描述。
挤压的聚合物管或薄板被加工成此处所述的固定模，即一个通过切割(例如激光切割或其他方法)而成的具有一系列适合于运动的可膨胀的模段的长条。通过例如把模段加热到或高于其热转变温度，迫使条状模段转变成其闭合状态并且将模段冷却到该转变温度以下，就可使固定模模段从其记忆状态处于其闭合状态。通常如下面将说明的，把固定模模段卷绕在气囊导管的气囊周围，以便放置在目标位置上。
在本发明的一个实施例中，固定模包含一种治疗剂以便有控制把该剂释放在目标位置。该治疗剂可以在固定模制成后，或者更好是在聚合物进行挤压以前或在聚合物板或管进行聚合反应以前通过无源扩散加入到固定模中。典型的治疗剂包括用来防止血栓形成的肝磷酯；抗增生剂，例如甲氨喋呤；血管舒张药，例如钙管道阻滞剂；硝酸盐；抗血小板剂，例如血小板抑制剂或abciximab(ReoProTM)；或者凝块分解酶，例如细胞组织纤维蛋白溶酶原激活剂。另外的治疗剂可以是用于治疗良性的前列腺增生的finasteride(Proscar)。
在本发明的另一个实施例中，固定模包括一种不透射线材料，例如金、不锈钢、铂、钽；金属盐，例如硫酸钡，或者含碘试剂，例如OmniPaque(Sanofi Winthrop Pharmaceuticals)。该不透射线材料可以在固定模挤压以前加入到记忆聚合物中，或者可以把不透射线材料的涂层施加在该固定模上。该不透射线材料提供了可以在固定模放置时或放置后通过X射线或其他影象技术用来确定固定模位置的装置。
图2A-2C示出了本发明的移植片固定模的第二实施例，其中固定模50由一系列可膨胀的条状模段连接成的一个V形整体带所构成。如图2A中所示，该V形整体带52具有两个部分(或分支)54，56，每个部分由多个模段例如58，60，62所构成。模段58(它是代表性的)由侧面64，66和端面68，70所限定。
这些条状模段沿其偏置的侧面部位连接成阶梯状。模段58，60沿模段58的偏置侧面66和模段60的偏置侧面76相连接。示于图2A中的整体条带52处于其中平板形的记忆，但可以理解的是，整体条带52也可以采取管形结构作为其预先选定的记忆状态。
如图2B中所示，通过把这些条状模段暴露在一个如上所述的刺激源中以激活聚合物转变，可使每个条状模块都处于其闭合的大曲率状态。例如，可将聚合物模段加热到其玻璃化转变温度或其晶体熔点。把加热的条状模段卷绕在气囊导管的周围并且使它冷却到转变温度以下从而将该模段固定在其闭合状态。图2B示出了图2A的条带的模段片地其闭合的大曲率状态，从而形成了一个可变形的圆柱形套筒。把每个条状模段的端面(例如模段58的端面68，70)组合在一起，以使该模段处于其闭合状态。处于其闭合状态的每个模段的端面可以互相接触，或者也可以在端面之间有一个间隙。
整体条带52可以通过以相同方向或相反方向卷绕分支54，56而绕成其闭合状态。例如，分支54可以沿第一方向卷绕，使得端面68处于模段58的下面而与端面70接触。分支56沿相反方向卷绕，使得端面84处于模段85的上面而与端面86接触。当暴露在一个刺激源中时，每个分支的模段都沿径向膨胀，但膨胀的方向相反。固定模在脉管中的膨胀具有很小的或没有横向运动，因而可使固定模能在脉管中的目标位置上方便的精确的放置。
图2C示出了固定模通过径向运动使其条状模段膨胀到其打开的小曲率状态。通过把固定模暴露在一个刺激源(例如热量)中而使模段膨胀，以激活聚合物状态转变，例如玻璃化转变。这些模段沿径向向其记忆状态膨胀，直到模段的运动受到管壁的限制为止。这样，固定模在脉管中就处于其膨胀的小曲率状态。
本发明还设想了一种由V形长聚合物带构成的固定模。在该实施例中，该聚合物带的形状与图2A中所示的相类似，即具有两个分支部分的V形带。每个分支部分由单个条状模段所构成，该模段被螺旋形地卷绕，从而使固定模处于其闭合的大曲率状态。如上所述，该聚合物带的分支以相反的方向卷绕，从而使当膨胀到打开的小曲率状态时，分支部分以相反的方向展开。
图3A-3C示出了一个由具有单个条状模段的长带构成的固定模90，其中该单个模段具有一个平行四边形的形状(图3A-3C)。从图3A中可见，处于其记忆状态的模段92是一个具有平行四边形形状的平带。通过激发聚合物转变并且把该模段卷烧在气囊导管周围可使该模段处于其闭合的大曲率状态。把该模段冷却到其转变温度以下，以便保证它处于其大曲率小直径构成，如图3B中所示。在该构形中，固定模采取可变形的圆柱形套筒的形状。当激活聚合物转变时，该模段向其记忆状态膨胀到其打开的小曲率状态，如图3C中所示。该膨胀一直继续到脉管壁限制该运动为止。
如上所述，在本发明的一个实施例中，一种不透射线材料被加入到固定模中或涂覆在固定模上以帮助把固定模定位和/或固定在脉管中。重要的是，该不透射线材料变以下列方式加入，即使不透射线材料的数量减至最少并且同时加强固定模的不透明度以改进目测效果。
包含不透射线材料的固定模示于图4A-4D中。图4A-4B示出了图2中的固定模50，其中阴影部分表示包含不透射线材料(诸如金、硫酸钡或上面列出的其他材料)的部位。在图4A中，不透射线材料包含在每个条状模段例如模段58，60，62的一部分中。这样，当固定模卷绕成其小直径状态时，可使该模的不透射线材料沿其全长分布所需要的不透射线材料减至最少。图4B示出了同样的固定模，但该不透射线材料只包含在几个用阴影区所表示的几个特含定的部位中。
图4C和4D分别示出了3个分支和4个分支的固定模，其中固定模的每个“分支”由单个条状模段所构成。例如，固定模93由模段94，95，96构成。每个模段包含着由图中的阴影部分表示的不透射线材料。当固定模被卷绕成其小直径状态时，沿着固定模长度上包含有不透射线材料。4个分支的固定模97示出于图4D中，其中该固定模的每个分支都有一个包含不透射线材料的部位，例如分支99的部位98。该固定模当被卷绕成其小直径状态时具有不透射线材料的重叠区域，从而加强了目测固定模的不透明度。
如上所述，本发明的固定模在用于防止动脉的再狭窄时，通常借助于经管腔的血管成形术导管进行放置。从图5A中可见，气囊导管100用来把固定模102传送到血管104中的一个狭窄区处。固定模102采以可变形的圆柱形套筒的形状，使每个固定模模段处于其闭合的小曲率状态，该套筒装在导管的未膨胀的气囊106上。该导管通过一根常规的导丝钩导入并且利用例如荧光成象把固定模定位在目标位置上。
在固定模被正确定位后，就将囊106充满液体以刺激该固定模的聚合物状态转变。如上所述，聚合物转变可以由加热激活或者通过pH值的变化或吸收液体而被激活。固体模在暴露在刺激源中时，固定模就从其闭合的小曲率状态向其记忆状态膨胀。例如，具有加热激活聚合物转变的固定模通过在导管囊中装满加热液体(例如加热到约40-100℃之间的造影剂)而受激活产生膨胀。来自该液体的热量由聚合物固定模所吸收。导管本身可以设计成能喷射加热液体并且具有良好的传热。例如，该导管可以具有用于加热液体在该导管的囊区域中重复循环的两个腔。
刺激源也可以是pH值刺激源或液体刺激源，其中把具有选定pH值的缓冲液导入囊中。在围绕该囊放置固定模以前已造成的囊的小孔将允许该液体与固定模接触。此处所用的术语“当暴露于液体中时”的含义包括固定模暴露在加热液体的热量中以及暴露在液体本身中。
在一个最佳实施例中，刺激源是一个热刺激源，加热液体被导入该囊中。来自该液体的热量被接续地传导到聚合物固定模上，把该固定模的温度提高到其热转变温度，例如在约25-60℃之间的玻璃化转变温度，该温度在30-50℃之间更好，在35-48℃之间则最好。如图5B中所示，固定模模段受刺激源的控制向着其记忆状态运动。由图可见，固定模102沿径向向其膨胀的小曲率状态膨胀。这种运动持续进行直至模段受到管壁的限制为止，如图5C中所示。当固定模的模段全部在其小曲率的膨胀状态展开时，导管就可以沿导丝钩抽出并且取下该导丝钩。
虽然本发明已经对特定的几个实施例进行了说明，但对于本领域技术熟练的人来说显而易见的是，只要不脱离本发明的精神和范围，可以对本发明作出各种变化和改进。

Claims (30)

1.一种用来安装在气囊导管的囊上送到脉管中的目标位置处的移植片固定模，包括：
一系列可膨胀的条状模段，当暴露于一个选定的刺激源中时，每个模段都适合于在闭合的大曲率状态与膨胀的小曲率状态之间大体上沿着径向运动；
所述模段沿其偏置的侧面部位这样的连接，使得该模段处于其大曲率状态，该固定模适合于在该囊上形成一个可变形的圆柱形套筒，并且当它暴露在该刺激源中时，在该固定模中的该模段就向着其小曲率状态膨胀，直到该运动受到该脉管的壁的限制为止。
2.如权利要求1所述的移植片固定模，其中，当该固定模处于其记忆状态时，所述模段形成一个长条形整体带。
3.如权利要求1所述的移植片固定模，其中，当该固定模处于其记忆状态时，所述模段形成一个V形整体带。
4.如权利要求1所述的移植片固定模，其中，所述条状模段是由记忆聚合物制成的。
5.如权利要求4所述的移植片固定模，其中，所述条状模段是由热塑性聚合物制成的。
6.如权利要求4所述的移植片固定模，其中，所述条状模段是由交联热塑性聚合物制成的。
7.如权利要求4所述的移植片固定模，其中，所述条状模段是由热塑性共混聚合物制成的。
8.如权利要求4所述的移植片固定模，其中，所述条状模段是由交联热塑性共混聚合物制成的。
9.如权利要求4所述的移植片固定模，其中，所述记忆聚合物是一种含甲基丙烯酸酯的聚合物。
10.如权利要求4所述的移植片固定模，其中，所述记忆聚合物是一种含丙烯酸酯的聚合物。
11.如权利要求4所述的移植片固定模，其中，所述记忆聚合物是生物可降解的。
12.如权利要求4所述的移植片固定模，其中，所述模段包含一种治疗剂，以便有控制地把所述治疗剂释放到该目标位置。
13.如权利要求1所述的移植片固定模，其中，所述模段是由具有聚合物状态转变特性的记忆聚合物制成的，该转变是由下列刺激源中的一个刺激源所激活的：
(a)通过所述聚合物吸收热量；
(b)通过所述聚合物吸附液体；以及
(c)在一种与所述聚合物接触的液体中pH值的变化。
14.如权利要求1所述的移植片固定模，其中，所述模段是由具有质热激活聚合物状态转变特性的记忆聚合物制成的，该状态转变选自：
(a)该聚合物的熔点；
(b)该聚合物的玻璃化转变；
(c)一种液晶转变；以及
(d)一种局部模式分子转变。
15.如权利要求14所述的移植片固定模，其中，所述转变是在约25℃与65℃之间的玻璃化转变。
16.如权利要求14所述的移植片固定模，其中，所述转变是在约25-65℃之间的结晶熔点。
17.如权利要求1所述的移植片固定模，其中，处于其打开的小曲率状态的所述模段的外径约在0.1毫米至50毫米之间。
18.如权利要求1所述的移植片固定模，其中，所述模段具有一个约在2至2000之间的膨胀比。
19.一种用来把移植片固定模输送到脉管中的目标位置上的气囊导管装置，包括：
一个在其一端具有一个能充满液体的囊的气囊导管；
一个移植片固定模，该固定模由一系列可膨胀的条状模段所构成，每个模段当暴露于所述液体中时都适合于在闭合的大曲认状态与膨胀的小曲率状态之间大体上沿着径向运动；
所述模段沿其偏置的侧面部位这样的连接，使得该模段处于其大曲率状态，该固定模适合于在所述囊上形成一个可变形的圆柱形套筒，并且当它暴露在所述液体中时，在该固定模中的该模段就向着其小曲率状态膨胀，直到该运动受到该脉管的壁的限制为止。
20.如权利要求19所述的装置，其中，所述固定模是由一个具有聚合物状态转变特性的记忆聚合物制成的，该状态转变是由下列方式之一所激活的：
(a)通过所述聚合物吸收热量；
(b)通过所述聚合物吸附液体；以及
(c)在一种与所述聚合物接触的液体中pH值的变化。
21.如权利要求20所述的装置，其中，所述液体被加热到在25至100℃之间的一个温度，所述转变是由从所述液体吸收热量所激活的热转变，该转变选自下列方式之一：
(a)该聚合物的熔点；
(b)该聚合物的玻璃化转变；
(c)一种液晶转变；以及
(d)一种局部模式分子转变。
22.如权利要求20所述的移植片固定模，其中，所述转变是在约25-65℃之间的玻璃化转变。
23.如权利要求20所述的移植片固定模，其中，所述记忆聚合物是一种含甲基丙烯酸酯的聚合物。
24.如权利要求20所述的移植片固定模，其中，所述记忆聚合物是一种含丙烯酸酯的聚合物。
25.如权利要求20所述的移植片固定模，其中，所述记忆聚合物是生物可降解的。
26.如权利要求20所述的移植片固定模，其中，所述条状模段是由热塑性聚合物制成的。
27.如权利要求20所述的移植片固定模，其中，所述条状模段是由交联热塑性聚合物制成的。
28.如权利要求20所述的移植片固定模，其中，所述条状模段是由热塑性共混聚合物制成的。
29如权利要求20所述的移植片固定模，其中，所述条状模段是由交联热塑性共混聚合物制成的。
30.如权利要求20所述的移植片固定模，其中，所述模段包含一种治疗剂，以便有控制地把所述治疗剂释放到该目标位置。
CN96196048A 1995-06-06 1996-06-04 血管内的移植片固定模 Pending CN1192668A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/486,271 US5603722A (en) 1995-06-06 1995-06-06 Intravascular stent
US08/486,271 1995-06-06

Publications (1)

Publication Number Publication Date
CN1192668A true CN1192668A (zh) 1998-09-09

Family

ID=23931240

Family Applications (1)

Application Number Title Priority Date Filing Date
CN96196048A Pending CN1192668A (zh) 1995-06-06 1996-06-04 血管内的移植片固定模

Country Status (9)

Country Link
US (1) US5603722A (zh)
EP (1) EP0831754B1 (zh)
JP (1) JP3188275B2 (zh)
CN (1) CN1192668A (zh)
AT (1) ATE247434T1 (zh)
AU (1) AU697779B2 (zh)
CA (1) CA2222892C (zh)
DE (1) DE69629565T2 (zh)
WO (1) WO1996039103A1 (zh)

Families Citing this family (139)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5954744A (en) * 1995-06-06 1999-09-21 Quanam Medical Corporation Intravascular stent
US7550005B2 (en) * 1995-06-07 2009-06-23 Cook Incorporated Coated implantable medical device
US7611533B2 (en) * 1995-06-07 2009-11-03 Cook Incorporated Coated implantable medical device
US6774278B1 (en) * 1995-06-07 2004-08-10 Cook Incorporated Coated implantable medical device
US7896914B2 (en) * 1995-06-07 2011-03-01 Cook Incorporated Coated implantable medical device
KR100452916B1 (ko) * 1995-07-25 2005-05-27 메드스텐트 인코퍼레이티드 확장 가능한 스텐트
US6261318B1 (en) 1995-07-25 2001-07-17 Medstent Inc. Expandable stent
US6579305B1 (en) * 1995-12-07 2003-06-17 Medtronic Ave, Inc. Method and apparatus for delivery deployment and retrieval of a stent comprising shape-memory material
US5707387A (en) * 1996-03-25 1998-01-13 Wijay; Bandula Flexible stent
US6007573A (en) * 1996-09-18 1999-12-28 Microtherapeutics, Inc. Intracranial stent and method of use
US6254628B1 (en) 1996-12-09 2001-07-03 Micro Therapeutics, Inc. Intracranial stent
US7749585B2 (en) * 1996-10-08 2010-07-06 Alan Zamore Reduced profile medical balloon element
US6273913B1 (en) 1997-04-18 2001-08-14 Cordis Corporation Modified stent useful for delivery of drugs along stent strut
JP4083241B2 (ja) * 1997-04-23 2008-04-30 アーテミス・メディカル・インコーポレイテッド 分岐ステント及び遠位保護システム
US6174330B1 (en) * 1997-08-01 2001-01-16 Schneider (Usa) Inc Bioabsorbable marker having radiopaque constituents
US6485514B1 (en) * 1997-12-12 2002-11-26 Supergen, Inc. Local delivery of therapeutic agents
JP2003522550A (ja) * 1998-02-10 2003-07-29 アーテミス・メディカル・インコーポレイテッド 咬合、固定、テンショニング、及び流向装置とその使用方法
WO1999039648A1 (en) 1998-02-10 1999-08-12 Dubrul William R Entrapping apparatus and method for use
US6602265B2 (en) * 1998-02-10 2003-08-05 Artemis Medical, Inc. Tissue separation medical device and method
US7027398B2 (en) * 2001-04-12 2006-04-11 General Instrument Corporation Method and apparatus for monitoring voice conversations from customer premises equipment
US20020144696A1 (en) * 1998-02-13 2002-10-10 A. Adam Sharkawy Conduits for use in placing a target vessel in fluid communication with a source of blood
EP1054641A1 (en) * 1998-02-13 2000-11-29 Ventrica Inc. Methods and devices providing transmyocardial blood flow to the arterial vascular system of the heart
US6651670B2 (en) * 1998-02-13 2003-11-25 Ventrica, Inc. Delivering a conduit into a heart wall to place a coronary vessel in communication with a heart chamber and removing tissue from the vessel or heart wall to facilitate such communication
US6033436A (en) * 1998-02-17 2000-03-07 Md3, Inc. Expandable stent
US20070142901A1 (en) * 1998-02-17 2007-06-21 Steinke Thomas A Expandable stent with sliding and locking radial elements
US6623521B2 (en) * 1998-02-17 2003-09-23 Md3, Inc. Expandable stent with sliding and locking radial elements
US6224626B1 (en) 1998-02-17 2001-05-01 Md3, Inc. Ultra-thin expandable stent
US6241762B1 (en) 1998-03-30 2001-06-05 Conor Medsystems, Inc. Expandable medical device with ductile hinges
US8029561B1 (en) 2000-05-12 2011-10-04 Cordis Corporation Drug combination useful for prevention of restenosis
US20070087028A1 (en) * 1998-04-16 2007-04-19 Robert Falotico Intraluminal devices for the prevention and treatment of vascular disease
US6179860B1 (en) 1998-08-19 2001-01-30 Artemis Medical, Inc. Target tissue localization device and method
DE60004630T2 (de) * 1999-01-12 2004-06-17 Quanam Medical Corp., Santa Clara Arzneimittel und verfahren zur verabreichung von wasserunlöslichen paclitaxelderivaten
US6530950B1 (en) * 1999-01-12 2003-03-11 Quanam Medical Corporation Intraluminal stent having coaxial polymer member
US7025773B2 (en) 1999-01-15 2006-04-11 Medtronic, Inc. Methods and devices for placing a conduit in fluid communication with a target vessel
US7578828B2 (en) * 1999-01-15 2009-08-25 Medtronic, Inc. Methods and devices for placing a conduit in fluid communication with a target vessel
US6635214B2 (en) * 1999-09-10 2003-10-21 Ventrica, Inc. Manufacturing conduits for use in placing a target vessel in fluid communication with a source of blood
US20080018016A1 (en) * 1999-09-10 2008-01-24 Rapacki Alan R Manufacturing conduits for use in placing a target vessel in fluid communication with a source of blood
US9522217B2 (en) 2000-03-15 2016-12-20 Orbusneich Medical, Inc. Medical device with coating for capturing genetically-altered cells and methods for using same
US8088060B2 (en) 2000-03-15 2012-01-03 Orbusneich Medical, Inc. Progenitor endothelial cell capturing with a drug eluting implantable medical device
US8460367B2 (en) 2000-03-15 2013-06-11 Orbusneich Medical, Inc. Progenitor endothelial cell capturing with a drug eluting implantable medical device
ATE362382T1 (de) 2000-03-15 2007-06-15 Orbusneich Medical Inc Beschichtung welche ein anhaften von endothelzellen stimuliert
US8236048B2 (en) * 2000-05-12 2012-08-07 Cordis Corporation Drug/drug delivery systems for the prevention and treatment of vascular disease
US20050002986A1 (en) * 2000-05-12 2005-01-06 Robert Falotico Drug/drug delivery systems for the prevention and treatment of vascular disease
US20040243097A1 (en) * 2000-05-12 2004-12-02 Robert Falotico Antiproliferative drug and delivery device
US6776796B2 (en) 2000-05-12 2004-08-17 Cordis Corportation Antiinflammatory drug and delivery device
IL137090A (en) 2000-06-29 2010-04-15 Pentech Medical Devices Ltd Polymeric stent
EP1179353A1 (de) * 2000-08-11 2002-02-13 B. Braun Melsungen Ag Antithrombogene Implantate mit Beschichtung aus Polyphosphazenen und einem pharmakologisch aktiven Wirkstoff
US20020111590A1 (en) * 2000-09-29 2002-08-15 Davila Luis A. Medical devices, drug coatings and methods for maintaining the drug coatings thereon
ATE343969T1 (de) * 2000-09-29 2006-11-15 Cordis Corp Beschichtete medizinische geräte
US20020051730A1 (en) * 2000-09-29 2002-05-02 Stanko Bodnar Coated medical devices and sterilization thereof
US7261735B2 (en) * 2001-05-07 2007-08-28 Cordis Corporation Local drug delivery devices and methods for maintaining the drug coatings thereon
EP1498084B1 (en) * 2000-10-16 2014-06-18 Innovational Holdings, LLC Expandable medical device for delivery of beneficial agent
US6613089B1 (en) * 2000-10-25 2003-09-02 Sdgi Holdings, Inc. Laterally expanding intervertebral fusion device
AU2002243270B2 (en) 2000-10-25 2006-03-09 Warsaw Orthopedic, Inc. Vertically expanding intervertebral body fusion device
US20020123786A1 (en) * 2001-03-02 2002-09-05 Ventrica, Inc. Methods and devices for bypassing an obstructed target vessel by placing the vessel in communication with a heart chamber containing blood
US7056339B2 (en) * 2001-04-20 2006-06-06 The Board Of Trustees Of The Leland Stanford Junior University Drug delivery platform
US8182527B2 (en) * 2001-05-07 2012-05-22 Cordis Corporation Heparin barrier coating for controlled drug release
US6585755B2 (en) * 2001-06-29 2003-07-01 Advanced Cardiovascular Polymeric stent suitable for imaging by MRI and fluoroscopy
US7195640B2 (en) * 2001-09-25 2007-03-27 Cordis Corporation Coated medical devices for the treatment of vulnerable plaque
US7108701B2 (en) * 2001-09-28 2006-09-19 Ethicon, Inc. Drug releasing anastomosis devices and methods for treating anastomotic sites
US20030065345A1 (en) * 2001-09-28 2003-04-03 Kevin Weadock Anastomosis devices and methods for treating anastomotic sites
US20030065382A1 (en) * 2001-10-02 2003-04-03 Fischell Robert E. Means and method for the treatment of coronary artery obstructions
US20030077310A1 (en) 2001-10-22 2003-04-24 Chandrashekhar Pathak Stent coatings containing HMG-CoA reductase inhibitors
US20030114919A1 (en) * 2001-12-10 2003-06-19 Mcquiston Jesse Polymeric stent with metallic rings
US7691461B1 (en) 2002-04-01 2010-04-06 Advanced Cardiovascular Systems, Inc. Hybrid stent and method of making
US20030216804A1 (en) * 2002-05-14 2003-11-20 Debeer Nicholas C. Shape memory polymer stent
AU2003243439A1 (en) * 2002-06-10 2003-12-22 Leo Rubin Medical device for intra-lumenal delivery of pharmaceutical agents
US20030236533A1 (en) * 2002-06-20 2003-12-25 The Regents Of The University Of California Shape memory polymer actuator and catheter
US20040034405A1 (en) * 2002-07-26 2004-02-19 Dickson Andrew M. Axially expanding polymer stent
AU2003259784A1 (en) 2002-08-13 2004-02-25 Cook Ireland Ltd. Ercp catheter with a removable handle for lithotriptor compatible basket
US7794494B2 (en) 2002-10-11 2010-09-14 Boston Scientific Scimed, Inc. Implantable medical devices
FR2847150B1 (fr) * 2002-11-15 2005-01-21 Claude Mialhe Dispositif occlusif a destination medicale ou chirurgicale
US20050165469A1 (en) * 2002-12-24 2005-07-28 Michael Hogendijk Vascular prosthesis including torsional stabilizer and methods of use
US7455687B2 (en) * 2002-12-30 2008-11-25 Advanced Cardiovascular Systems, Inc. Polymer link hybrid stent
CA2527976C (en) * 2003-06-13 2011-11-22 Mnemoscience Gmbh Stents
JP4798662B2 (ja) * 2003-06-13 2011-10-19 ゲーカーエスエスフォルシュングスツェントゥルム ゲーストハハト ゲーエムベーハー ステント
WO2005044142A2 (en) * 2003-11-10 2005-05-19 Angiotech International Ag Intravascular devices and fibrosis-inducing agents
US7744604B2 (en) * 2003-11-13 2010-06-29 Lawrence Livermore National Security, Llc Shape memory polymer medical device
WO2005107817A2 (en) 2004-04-30 2005-11-17 Orbus Medical Technologies, Inc. Medical device with coating for capturing genetically-altered cells and methods of using same
US7763065B2 (en) 2004-07-21 2010-07-27 Reva Medical, Inc. Balloon expandable crush-recoverable stent device
US8043361B2 (en) * 2004-12-10 2011-10-25 Boston Scientific Scimed, Inc. Implantable medical devices, and methods of delivering the same
US8292944B2 (en) 2004-12-17 2012-10-23 Reva Medical, Inc. Slide-and-lock stent
WO2006108114A2 (en) 2005-04-01 2006-10-12 The Regents Of The University Of Colorado A graft fixation device and method
US7674296B2 (en) * 2005-04-21 2010-03-09 Globus Medical, Inc. Expandable vertebral prosthesis
US9149378B2 (en) 2005-08-02 2015-10-06 Reva Medical, Inc. Axially nested slide and lock expandable device
US7914574B2 (en) * 2005-08-02 2011-03-29 Reva Medical, Inc. Axially nested slide and lock expandable device
US20070156230A1 (en) 2006-01-04 2007-07-05 Dugan Stephen R Stents with radiopaque markers
US20090248141A1 (en) * 2006-03-30 2009-10-01 The Regents Of The University Of Colorado Shape Memory Polymer Medical Devices
US20130325107A1 (en) 2006-05-26 2013-12-05 Abbott Cardiovascular Systems Inc. Stents With Radiopaque Markers
US7568753B2 (en) * 2006-06-15 2009-08-04 Mattel, Inc. Children's ride-on vehicles with reconfigured bodies and methods for forming the same
US8535372B1 (en) 2006-06-16 2013-09-17 Abbott Cardiovascular Systems Inc. Bioabsorbable stent with prohealing layer
US8128688B2 (en) * 2006-06-27 2012-03-06 Abbott Cardiovascular Systems Inc. Carbon coating on an implantable device
US7823263B2 (en) 2006-07-11 2010-11-02 Abbott Cardiovascular Systems Inc. Method of removing stent islands from a stent
US7704275B2 (en) 2007-01-26 2010-04-27 Reva Medical, Inc. Circumferentially nested expandable device
US9017395B2 (en) * 2007-03-09 2015-04-28 Novostent Corporation Vascular prosthesis and methods of use
US8002815B2 (en) 2007-03-09 2011-08-23 Novostent Corporation Delivery system and method for vascular prosthesis
US8348994B2 (en) * 2007-03-09 2013-01-08 Novostent Corporation Vascular prosthesis with alternating helical sections
US20080221658A1 (en) * 2007-03-09 2008-09-11 Novostent Corporation Vascular prosthesis and methods of use
US8372138B2 (en) * 2007-06-12 2013-02-12 Boston Scientific Scimed, Inc. Shape memory polymeric stent
US7901452B2 (en) * 2007-06-27 2011-03-08 Abbott Cardiovascular Systems Inc. Method to fabricate a stent having selected morphology to reduce restenosis
US7955381B1 (en) 2007-06-29 2011-06-07 Advanced Cardiovascular Systems, Inc. Polymer-bioceramic composite implantable medical device with different types of bioceramic particles
EP2211773A4 (en) 2007-11-30 2015-07-29 Reva Medical Inc AXIAL-RADIAL NESTED EXPANDABLE DEVICE
US10028747B2 (en) 2008-05-01 2018-07-24 Aneuclose Llc Coils with a series of proximally-and-distally-connected loops for occluding a cerebral aneurysm
US10716573B2 (en) 2008-05-01 2020-07-21 Aneuclose Janjua aneurysm net with a resilient neck-bridging portion for occluding a cerebral aneurysm
US7947071B2 (en) * 2008-10-10 2011-05-24 Reva Medical, Inc. Expandable slide and lock stent
WO2010048052A1 (en) 2008-10-22 2010-04-29 Boston Scientific Scimed, Inc. Shape memory tubular stent with grooves
US8721723B2 (en) * 2009-01-12 2014-05-13 Globus Medical, Inc. Expandable vertebral prosthesis
EP2393625A1 (en) * 2009-02-03 2011-12-14 Abbott Cardiovascular Systems Inc. Improved laser cutting process for forming stents
WO2010091106A1 (en) * 2009-02-03 2010-08-12 Abbott Cardiovascular Systems Inc. Improved laser cutting system
WO2010091100A1 (en) 2009-02-03 2010-08-12 Abbott Cardiovascular Systems Inc. Multiple beam laser system for forming stents
CA2785621C (en) 2009-04-02 2015-12-22 The Regents Of The University Of Colorado, A Body Corporate Vascular occlusion devices
US8425586B2 (en) * 2009-09-02 2013-04-23 Novostent Corporation Vascular prosthesis with stress relief slots
US9155640B2 (en) * 2009-11-16 2015-10-13 Tre′ Raymond Welch Stent and method for manufacturing thereof
US9358140B1 (en) 2009-11-18 2016-06-07 Aneuclose Llc Stent with outer member to embolize an aneurysm
US8568471B2 (en) 2010-01-30 2013-10-29 Abbott Cardiovascular Systems Inc. Crush recoverable polymer scaffolds
US8808353B2 (en) 2010-01-30 2014-08-19 Abbott Cardiovascular Systems Inc. Crush recoverable polymer scaffolds having a low crossing profile
US9089628B2 (en) 2010-03-18 2015-07-28 Agency For Science, Technology And Research Biodegradable and biocompatible shape memory polymers
AU2011237303B2 (en) 2010-04-10 2013-10-31 Reva Medical, Inc Expandable slide and lock stent
US9301850B2 (en) 2010-04-12 2016-04-05 Globus Medical, Inc. Expandable vertebral implant
US8591585B2 (en) 2010-04-12 2013-11-26 Globus Medical, Inc. Expandable vertebral implant
US8282683B2 (en) 2010-04-12 2012-10-09 Globus Medical, Inc. Expandable vertebral implant
US8870880B2 (en) 2010-04-12 2014-10-28 Globus Medical, Inc. Angling inserter tool for expandable vertebral implant
US8556511B2 (en) 2010-09-08 2013-10-15 Abbott Cardiovascular Systems, Inc. Fluid bearing to support stent tubing during laser cutting
US9427493B2 (en) 2011-03-07 2016-08-30 The Regents Of The University Of Colorado Shape memory polymer intraocular lenses
USD665500S1 (en) 2011-04-15 2012-08-14 Novostent Corporation Stent
US8726483B2 (en) 2011-07-29 2014-05-20 Abbott Cardiovascular Systems Inc. Methods for uniform crimping and deployment of a polymer scaffold
WO2014160320A2 (en) 2013-03-13 2014-10-02 Endoshape Inc. Continuous embolic coil and methods and devices for delivery of the same
WO2013109784A1 (en) 2012-01-17 2013-07-25 Endoshape, Inc. Occlusion device for a vascular or biological lumen
US9408732B2 (en) 2013-03-14 2016-08-09 Reva Medical, Inc. Reduced-profile slide and lock stent
US9907684B2 (en) 2013-05-08 2018-03-06 Aneuclose Llc Method of radially-asymmetric stent expansion
US9999527B2 (en) 2015-02-11 2018-06-19 Abbott Cardiovascular Systems Inc. Scaffolds having radiopaque markers
US9700443B2 (en) 2015-06-12 2017-07-11 Abbott Cardiovascular Systems Inc. Methods for attaching a radiopaque marker to a scaffold
DE102016118600B4 (de) 2016-09-30 2022-03-31 Acandis Gmbh Medizinische Vorrichtung, bandförmige Gitterstruktur, Set und Verfahren zur Herstellung dergleichen
CA3046087A1 (en) 2016-12-09 2018-06-14 Zenflow, Inc. Systems, devices, and methods for the accurate deployment of an implant in the prostatic urethra
US11213661B2 (en) 2018-01-05 2022-01-04 Cook Medical Technologies Llc Expandable medical device and method of use thereof
WO2020028643A1 (en) * 2018-08-02 2020-02-06 The Regents Of The University Of California Biodegradable zinc-based materials including dispersed nanostructures for biomedical applications
CN109394398B (zh) * 2018-09-14 2019-10-18 江西瑞济生物工程技术股份有限公司 一种可降解的可折叠生物羊膜复合修复支架
CA3156685A1 (en) 2019-11-19 2021-05-27 Zenflow, Inc. SYSTEMS, DEVICES AND METHODS FOR ACCURATE DEPLOYMENT AND IMAGING OF AN IMPLANT IN THE PROSTATIC URETHRA
US11464657B2 (en) 2019-11-22 2022-10-11 Tré Raymond Welch Stent and method of manufacture

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4733665C2 (en) * 1985-11-07 2002-01-29 Expandable Grafts Partnership Expandable intraluminal graft and method and apparatus for implanting an expandable intraluminal graft
JPH088933B2 (ja) * 1987-07-10 1996-01-31 日本ゼオン株式会社 カテ−テル
US5133732A (en) * 1987-10-19 1992-07-28 Medtronic, Inc. Intravascular stent
US5213580A (en) * 1988-08-24 1993-05-25 Endoluminal Therapeutics, Inc. Biodegradable polymeric endoluminal sealing process
CA1322628C (en) * 1988-10-04 1993-10-05 Richard A. Schatz Expandable intraluminal graft
US5189110A (en) * 1988-12-23 1993-02-23 Asahi Kasei Kogyo Kabushiki Kaisha Shape memory polymer resin, composition and the shape memorizing molded product thereof
US5236447A (en) * 1990-06-29 1993-08-17 Nissho Corporation Artificial tubular organ
US5139480A (en) * 1990-08-22 1992-08-18 Biotech Laboratories, Inc. Necking stents
US5163952A (en) * 1990-09-14 1992-11-17 Michael Froix Expandable polymeric stent with memory and delivery apparatus and method
US5354309A (en) * 1991-10-11 1994-10-11 Angiomed Ag Apparatus for widening a stenosis in a body cavity
US5370683A (en) * 1992-03-25 1994-12-06 Cook Incorporated Vascular stent
WO1995014500A1 (en) * 1992-05-01 1995-06-01 Beth Israel Hospital A stent
US5342348A (en) * 1992-12-04 1994-08-30 Kaplan Aaron V Method and device for treating and enlarging body lumens

Also Published As

Publication number Publication date
EP0831754B1 (en) 2003-08-20
ATE247434T1 (de) 2003-09-15
US5603722A (en) 1997-02-18
AU697779B2 (en) 1998-10-15
CA2222892C (en) 2002-12-24
WO1996039103A1 (en) 1996-12-12
JPH10510201A (ja) 1998-10-06
CA2222892A1 (en) 1996-12-12
DE69629565D1 (de) 2003-09-25
JP3188275B2 (ja) 2001-07-16
DE69629565T2 (de) 2004-02-26
AU5978396A (en) 1996-12-24
MX9709590A (es) 1998-07-31
EP0831754A1 (en) 1998-04-01

Similar Documents

Publication Publication Date Title
CN1192668A (zh) 血管内的移植片固定模
US5954744A (en) Intravascular stent
US7115691B2 (en) Polymer compositions for intraluminal stent
US5735897A (en) Intravascular stent pump
CN1529572B (zh) 带滑动而锁定的径向元件的可膨胀支架
US5258020A (en) Method of using expandable polymeric stent with memory
US7470283B2 (en) Biodegradable drug delivery material for stent
US6387124B1 (en) Biodegradable drug delivery vascular stent
US5551954A (en) Biodegradable drug delivery vascular stent
US6248129B1 (en) Expandable polymeric stent with memory and delivery apparatus and method
JP4334348B2 (ja) 改良された内部人工装置
JPH05509008A (ja) 生体吸収性ステント
CN1345209A (zh) 梯形可扩展斯坦特固定模
CN103764183A (zh) 生物可吸收聚(l-丙交酯)骨架降解曲线的控制
US8109994B2 (en) Biodegradable drug delivery material for stent
DE69942440D1 (de) Mehrschichtpolymerstrukturen, Verfahren zu ihrer Herstellung und ihre Verwendung
CN101522754A (zh) 用于医疗器械的可生物吸收聚合物组合物
CN101247778A (zh) 滑动锁紧支架
EP1140242B1 (en) Polymer compositions for intraluminal stent
CN103429196A (zh) 用于植入内腔结构中的医疗器械
Slepian et al. Polymeric endoluminal gel paving: hydrogel systems for local barrier creation and site-specific drug delivery
WO2000041738A1 (en) Polymer compositions for intraluminal stent
DE1694424C (de) Verfahren zur Herstellung von aus ver netzten Polymeren bestehenden Formkörpern durch Isocyanatvernetzung
JPS60242857A (ja) 人工血管

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication
REG Reference to a national code

Ref country code: HK

Ref legal event code: WD

Ref document number: 1015254

Country of ref document: HK