CN119032175A - 经修饰的间隔体寡聚物及其使用的方法 - Google Patents

经修饰的间隔体寡聚物及其使用的方法 Download PDF

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Publication number
CN119032175A
CN119032175A CN202380034549.XA CN202380034549A CN119032175A CN 119032175 A CN119032175 A CN 119032175A CN 202380034549 A CN202380034549 A CN 202380034549A CN 119032175 A CN119032175 A CN 119032175A
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China
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aso
molecule
group
methanesulfonyl
phosphoramidate
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CN202380034549.XA
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Chinese (zh)
Inventor
L·贝格尔曼
V·K·拉杰万什
L·埃尔特普
S·M·蒙特罗
洪劲
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Aligos Therapeutics Inc
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Aligos Therapeutics Inc
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
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    • C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • C12N2310/32—Chemical structure of the sugar
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/341—Gapmers, i.e. of the type ===---===
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CN202380034549.XA 2022-03-17 2023-03-16 经修饰的间隔体寡聚物及其使用的方法 Pending CN119032175A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202263321019P 2022-03-17 2022-03-17
US63/321,019 2022-03-17
PCT/US2023/015398 WO2023177808A1 (en) 2022-03-17 2023-03-16 Modified gapmer oligomers and methods of use thereof

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CN119032175A true CN119032175A (zh) 2024-11-26

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US (1) US20230383296A1 (enExample)
EP (1) EP4493694A1 (enExample)
JP (1) JP2025509552A (enExample)
KR (1) KR20240158340A (enExample)
CN (1) CN119032175A (enExample)
AU (1) AU2023236560A1 (enExample)
CA (1) CA3255691A1 (enExample)
TW (1) TW202345861A (enExample)
WO (1) WO2023177808A1 (enExample)

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CN118680948B (zh) * 2023-10-20 2025-08-22 思合基因(北京)生物科技有限公司 寡核苷酸及其在抗乙型肝炎病毒中的应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030203862A1 (en) * 1998-03-26 2003-10-30 Miraglia Loren J. Antisense modulation of MDM2 expression
US20150247141A1 (en) * 2012-09-14 2015-09-03 Rana Therapeutics, Inc. Multimeric oligonucleotide compounds
EP2899197B1 (en) * 2012-09-21 2017-03-22 Osaka University Oligonucleotide and artificial nucleoside having guanidine bridge
GB201408623D0 (en) * 2014-05-15 2014-07-02 Santaris Pharma As Oligomers and oligomer conjugates
TW201718618A (zh) * 2015-09-18 2017-06-01 田邊三菱製藥股份有限公司 架橋型核酸ＧｕＮＡ，其製造方法，及中間體化合物
EP3353305A4 (en) * 2015-09-25 2019-09-18 Ionis Pharmaceuticals, Inc. Conjugated antisense compounds and their use
US20200147124A1 (en) 2018-11-08 2020-05-14 Aligos Therapeutics, Inc. S-antigen transport inhibiting oligonucleotide polymers and methods
KR20220024192A (ko) * 2019-05-31 2022-03-03 알리고스 테라퓨틱스 인코포레이티드 변형된 갭머 올리고뉴클레오타이드 및 사용 방법
MX2023001222A (es) * 2020-07-28 2023-04-26 Ionis Pharmaceuticals Inc Compuestos y metodos para reducir la expresion de app.

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TW202345861A (zh) 2023-12-01
CA3255691A1 (en) 2023-09-21
EP4493694A1 (en) 2025-01-22
JP2025509552A (ja) 2025-04-11
US20230383296A1 (en) 2023-11-30
WO2023177808A1 (en) 2023-09-21
AU2023236560A1 (en) 2024-10-03
KR20240158340A (ko) 2024-11-04

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