CN1188013A - Drug for curing haemorrhoids and anal fissure disease and its preparing method - Google Patents
Drug for curing haemorrhoids and anal fissure disease and its preparing method Download PDFInfo
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- CN1188013A CN1188013A CN97110684A CN97110684A CN1188013A CN 1188013 A CN1188013 A CN 1188013A CN 97110684 A CN97110684 A CN 97110684A CN 97110684 A CN97110684 A CN 97110684A CN 1188013 A CN1188013 A CN 1188013A
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- anal fissure
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Abstract
The present invention discloses a new medicine for curing hemorrhoids and anal fissure. Said invention possesses two groups of medicines, in which first group uses notoginseng root, bletilla tuber, dictamnus root and scorpion as raw material, and second group uses rhubarb and flavescent sophora root as raw material. The above-mentioned two groups of medicines are respectively dried, pulverized and mixed to obtain two kinds of medicinal powder preparations. Said two powder preparations are passed through the processes of high-temp. sterilization and UV radiation sterilization, and can be made into capsule and tablet.
Description
The present invention relates to a kind of medicine for the treatment of hemorrhoid, anal fissure disease, is the Chinese patent medicine of feedstock production with the natural animal-plant medicine specifically, the invention still further relates to the preparation method of this medicine.
Hemorrhoid one disease, sickness rate is high, northeast has a proverb " ten people, nine hemorrhoid " just to be enough to illustrate this point, in life, often be accompanied by the frequent generation of hemorrhoid and constantly increase the weight of anal fissure disease and also give birth to thereupon, so anus pruritus causalgia, difficulty in defecation, disease such as have blood in stool also just become sick for this reason cardinal symptom.
At present, the medicine of treatment hemorrhoid, anal fissure disease as: paste class medicines such as umbilicus, medicine film, stype, ointment, the general effect of initial stage in disease is better, when being in a bad way, especially hemorrhoid, when anal fissure is concurrent, often because of constipation due to dry stool, make great efforts defecation and increase the weight of the state of an illness, this moment, those medicines were not because of all there being the effect that improves defecation condition, so therapeutic effect is relatively poor or do not have a therapeutic effect more, the general postoperative of operative treatment needs certain convalescent period, promptly influences also easily recurrence of work and life.
The object of the present invention is to provide a kind ofly have clearing away heat and loosing the bowels, the blood stasis dispelling granulation promoting is improved the therapeutic agent that the intestinal blood circulation can be cured hemorrhoid, anal fissure disease in a short time quickly.
Another object of the present invention provides the preparation method of the therapeutic agent of hemorrhoid, anal fissure disease.
Solution of the present invention is based on motherland's medical science to hemorrhoid, the pathogenetic understanding and the Therapeutic Principle of anal fissure disease, the proverb of teaching reference book of publishing with reference to the Compendium of Material Medica and the People's Health Publisher of Li Shizhen (1518-1593 A.D.) work " Chinese materia medica " and northeast proverb " there is stereotyped writing cattle＜Cortex Dictamni in family〉knife injury need not worry ", and the master Xu Jingtai old Mr. who is subjected to me treats the inspiration of the clinical experience of hemorrhoid with decocting Radix Sophorae Flavescentis egg, through clinical practice for many years, from motherland's medical treasure-house, filter out and have blood circulation promoting and blood stasis dispelling, heat-clearing and toxic substances removing, the relieving constipation damp eliminating, hemostasis and pain-relieving, the natural animal-plant medicine of detumescence and promoting granulation, by the theory of Chinese medical science prescription, make soft gelatin capsule (or tablet) according to gastrointestinal emptying mechanism and determine medicine time, the active ingredient of medicine is played a role at big enteral largely, improved the oral drug therapy hemorrhoid greatly, the clinical effectiveness of anal fissure disease.
Medicine of the present invention is made (consumption is weight percentage) by following component
Radix Notoginseng (main product Guangxi, Yunnan) 10--50% Pseudobulbus Bletillae (Rhizoma Bletillae) 25--40% Cortex Dictamni 6--20%
Radix Et Rhizoma Rhei 10--30% Radix Sophorae Flavescentis 6--20% Scorpio 3--20%
The formula optimization weight percentage ranges of preparation medicine of the present invention is:
Radix Notoginseng 20--45% Pseudobulbus Bletillae (Rhizoma Bletillae) 25--35% Cortex Dictamni 8--15%
Radix Et Rhizoma Rhei 12--20% Radix Sophorae Flavescentis 6--15% Scorpio 4--12%
The optimum weight percentage ratio of pharmaceutical formulation of the present invention is:
Radix Notoginseng 33% Pseudobulbus Bletillae (Rhizoma Bletillae) 27% Cortex Dictamni 11% Radix Et Rhizoma Rhei 14% Radix Sophorae Flavescentis 7% Scorpio 8%
Above-mentioned each component is made medicine production method of the present invention is:
1, earlier with each medicine difference drying and crushing to 80 order fine powder.
2, with the fine powder of above-mentioned various medicines, dividing two groups of mixing in proportion is Radix Notoginseng, Pseudobulbus Bletillae (Rhizoma Bletillae), Cortex Dictamni, Scorpio mixing, and Radix Et Rhizoma Rhei, Radix Sophorae Flavescentis mix.Earlier Radix Notoginseng, Pseudobulbus Bletillae (Rhizoma Bletillae), Cortex Dictamni, Scorpio group medicine are at high temperature carried out sterilization treatment then, temperature is raised to 60 ℃ of temperature-gradient methods to 75 thereafter ℃, sterilization time is 10--30 minute, again Radix Et Rhizoma Rhei, Radix Sophorae Flavescentis group medicine are placed on the thin plate after the sterilization, the average thickness of medicine is 0.5 millimeter, the irradiation of sterilizing under ultraviolet sterilizing lamp, the time is 1--2 hour.Two groups of drug powders after the sterilization are made soft gelatin capsule (or adding additives is pressed into sheet under negative pressure, dry and can obtain tablet with vacuum packaging).
An important feature of the present invention is in proportion Radix Notoginseng, Pseudobulbus Bletillae (Rhizoma Bletillae), Cortex Dictamni, Scorpio to be mixed, Radix Et Rhizoma Rhei, Radix Sophorae Flavescentis mix, be respectively charged into capsule (or making tablet) patient then and can add and subtract adjustment to the consumption of Radix Et Rhizoma Rhei, Radix Sophorae Flavescentis group pill (or tablet) according to the defecation condition of oneself.Generally be advisable (taking 1.5 grams under the normal condition) to arrange slight loose stool at every turn, the person of being hard and dry doubles to take, just rare person reduces by half and takes, diarrhea person withdraws this group pill, thereby the more difficult determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs method of the traditional Chinese medical science is grasped neatly in patient's hands, improved the clinical therapeutic efficacy of this medicine greatly hemorrhoid, anal fissure disease.
Another characteristics of the present invention are determined medicine time according to gastrointestinal emptying mechanism and ancients''s " sick infra taking medicine before meal " method of administration, and promptly ante cibum, half a minute took medicine.Because the water sample material about 10 minutes stomach begin emptying, half a minute ante cibum takes medicine and makes very fast pylorus near stomach behind the medicine clothes, and a large amount of food consumption of gastric the Digestive system of gastric, slowed down the dissolution velocity of this medicine at gastric, make medicine be discharged into intestinal in the short time behind clothes, the dry-powder medicament of soft gelatin capsule (or tablet) dissolving back the inside is admitted in the small intestinal after mixing after a while with Digestive system in small intestinal, hypomere, the active ingredient that has fully guaranteed this medicine plays a role at big enteral largely, and does not influence absorption and the utilization of small intestinal to nutrient substance.Make in the 2--3 of patient after taking medicine hour, large and small just obtain unimpeded, stoped absorption and the diffusion of inflammatory products in intestinal, thereby inflammation is just got rid of in a short time rapidly from large and small, given full play to the effect of this medicine to the relieving constipation damp eliminating of intestinal, hemostasis and pain-relieving, heat-clearing and toxic substances removing, blood stasis dispelling granulation promoting, hemorrhoid tuberculosis dissipated rapidly, breach healing, pain disappear, hemorrhoid, anal fissure disease obtain curing, and the normal function of anus and rectum is restored.
The clinical use result of medicine of the present invention shows that following advantage is arranged:
1, to select natural animal-plant medicine for use be raw material in the present invention, and each component meets the pharmaceutical control law regulation, and not have chemicals nontoxic to human body.
2, medicine of the present invention need not decoct the inconvenience of having avoided pained difficult clothes and having brought.
3, the patient can determine dosage according to the defecation condition of oneself, has improved the clinical therapeutic efficacy of this medicine to hemorrhoid, anal fissure disease greatly, has shortened treatment time to have alleviated patient's misery largely.
4, make more patient avoid painful and inconvenience and the higher surgery cost that operative treatment brought.
For showing that medicine of the present invention is to hemorrhoid, the therapeutic effect of anal fissure disease, the present invention is through the clinical observation of 116 routine systems, and selection medical history, the state of an illness, the year order, the hemorrhoid of sex and other Drug therapy anal fissure disease patient 128 example of holding concurrently is matched group, from my individual Chinese herbalist clinic＜Shangzhi village, Zhaoyang Town, Jiayin County clinic) the interior case of selecting, male's 66 examples in the test group, women's 50 examples, internal hemorrhoid anal fissure disease patient 58 examples of holding concurrently wherein, external hemorrhoid anal fissure disease patient 16 examples of holding concurrently, mixed hemorrhoid anal fissure disease patient 42 examples of holding concurrently, year makes 20--53 year, the course of disease 6 months--and 8 years, and under the situation of not using other medicines, take medicine of the present invention.128 routine hemorrhoid of matched group, 52 examples of holding concurrently among the anal fissure disease patient use Rongchang County safe, and 76 routine patients use MAYINGLONGZHICHUANGGAO.Observing 18 days, 6 days is a course of treatment, totally three courses of treatment.
Instructions of taking: 7.5 gram/time (this consumption is a body weight 55--75 kilogram, and other body weight can be added and subtracted as one sees fit), day clothes 2 times, half a minute ante cibum boiled water is taken after mixing it with water, the period in a medicine and the food that avoids pungent food in back 1 year of taking medicine.(anemia of pregnant woman and menstrual woman avoid clothes) clinical test results is as showing:
| Group | Classification | Patient's number | The number (individual) of fully recovering a course of treatment | The number (individual) of fully recovering two courses of treatment | The number (individual) of fully recovering three courses of treatment | Substantially effectively (the approaching recovery from illness) counts | Invalid |
| Test group | The internal hemorrhoid anal fissure of holding concurrently | ????58 | ????36 | ????15 | ????4 | ????3 | |
| The external hemorrhoid anal fissure of holding concurrently | ????16 | ????12 | ????4 | ||||
| The mixed hemorrhoid anal fissure of holding concurrently | ????42 | ????23 | ????9 | ????6 | ????4 | ||
| Matched group | Prosperous Rong Kang element | ????52 | ????6 | ????8 | ????9 | ????12 | ????17 |
| MAYINGLONGZHICHUANGGAO | ????76 | ????9 | ????13 | ????18 | ????10 | ????26 |
As can be seen from the above table, the therapeutic effect of test group in three courses of treatment of using medicine of the present invention is very remarkable, and the effect with first course of treatment is the most quick especially.Most patients can both obtain curing in three courses of treatment soon, and utmost point individual patient is approaching recovery from illness when finish three courses of treatment.
Test statistics shows, with medicament of the present invention 116 hemorrhoid anal fissure disease patient that holds concurrently done therapeutic test, obtains 109 examples of recovery from illness, and near cured person 7 examples, cure rate reaches 93.96%, total effective rate 100%.
Embodiment
Take by weighing raw material by following proportioning
1.2 kilograms of 2.7 kilograms of Cortex Dictamni of 3.5 kilograms of Pseudobulbus Bletillae (Rhizoma Bletillae) of Radix Notoginseng (main product Guangxi, Yunnan)
1 kilogram of 1 kilogram of Scorpio of 2 kilograms of Radix Sophorae Flavescentiss of Radix Et Rhizoma Rhei
Production method is as follows:
With each medicine difference drying and crushing to 80 order fine powder, dividing two groups of mixing in proportion is Radix Notoginseng, Pseudobulbus Bletillae (Rhizoma Bletillae), Cortex Dictamni, Scorpio mixing earlier, and Radix Et Rhizoma Rhei, Radix Sophorae Flavescentis mix, and its disinfecting action is sterilizing methods and the ultraviolet sterilizing lamp irradiation that adopts the staged intensification.Earlier Radix Notoginseng, Pseudobulbus Bletillae (Rhizoma Bletillae), Cortex Dictamni, Scorpio group medicine be incubateds 10 minutes under 60 ℃ of temperature, and then be warmed up to 70 ℃ and kept 10 minutes, be warmed up to 75 ℃ of maintenances 10 minutes again, promptly obtain the powder of this group medicine.Again Radix Et Rhizoma Rhei, Radix Sophorae Flavescentis group medicine are layered on equably on the thin plate after the sterilization, the average thickness of medicine is 0.5 millimeter, 3 meters disposal one wavelength are 2 directly over thin plate, the irradiation of sterilizing of the ultraviolet sterilizing lamp of 537 , time is 2 hours, promptly obtain the powder of this group medicine, two groups of drug powders after the sterilization are made soft gelatin capsule (or tablet).
Claims (8)
1, a kind of medicine for the treatment of hemorrhoid, anal fissure disease is characterized in that it is the medicament of being made by following weight percentages.
Radix Notoginseng (main product Guangxi, Yunnan) 10--50% Pseudobulbus Bletillae (Rhizoma Bletillae) 25--40% Cortex Dictamni 6-20% Radix Et Rhizoma Rhei 10--30% Radix Sophorae Flavescentis 6--20% Scorpio 3--20%
2, the medicine of treatment hemorrhoid according to claim 1, anal fissure disease, wherein the percentage by weight of each raw material is:
Radix Notoginseng 20--45% Pseudobulbus Bletillae (Rhizoma Bletillae) 25--35% Cortex Dictamni 8--15% Radix Et Rhizoma Rhei 12--20% Radix Sophorae Flavescentis 6--15% Scorpio 4--12%
3, the medicine of treatment hemorrhoid according to claim 1, anal fissure disease, wherein the percentage by weight of each raw material is:
Radix Notoginseng 33% Pseudobulbus Bletillae (Rhizoma Bletillae) 27% Cortex Dictamni 11% Radix Et Rhizoma Rhei 14% Radix Sophorae Flavescentis 7% Scorpio 8%
4,, it is characterized in that said medicament is a said dosage form on any pharmaceutics according to the medicine of claim 1,2 or 3 described treatment hemorrhoid, anal fissure disease.
5, the medicine of treatment hemorrhoid according to claim 4, anal fissure disease is characterized in that said medicament is soft gelatin capsule or tablet.
6, the described treatment hemorrhoid of claim 5, the preparation method of anal fissure disease medicine, it is characterized in that various medicines difference drying and crushing to 80 order fine powders, dividing two groups of mixing in proportion is Radix Notoginseng, Pseudobulbus Bletillae (Rhizoma Bletillae), Cortex Dictamni, Scorpio mixes, Radix Et Rhizoma Rhei, Radix Sophorae Flavescentis mixes, its disinfecting action is sterilizing methods and the ultraviolet sterilizing lamp irradiation that adopts staged to heat up, earlier with Radix Notoginseng, Pseudobulbus Bletillae (Rhizoma Bletillae), Cortex Dictamni, Scorpio group medicine carried out under 60--75 ℃ of temperature sterilization treatment 10--30 minute, again with Radix Et Rhizoma Rhei, Radix Sophorae Flavescentis group medicine is sterilized under ultraviolet sterilizing lamp and was shone the powder of two groups of medicines after promptly obtaining sterilizing 1--2 hour.
7, treatment hemorrhoid according to claim 6, the preparation method of the drug powder of anal fissure disease, its disinfecting action is sterilizing methods and the ultraviolet sterilizing lamp irradiation that adopts staged to heat up, earlier with Radix Notoginseng, Pseudobulbus Bletillae (Rhizoma Bletillae), Cortex Dictamni, Scorpio group medicine places under 60 ℃ of temperature, and then temperature-gradient method to 75 ℃, sterilization time is 10--30 minute, promptly obtain the powder of this group medicine, again with Radix Et Rhizoma Rhei, Radix Sophorae Flavescentis group medicine is layered on the thin plate after the sterilization, adopting wavelength is 2,530-2, the irradiation of sterilizing of the ultraviolet sterilizing lamp of 650 , the time is 1--2 hour, promptly obtains the powder of this group medicine.
8, the preparation method of the drug powder of treatment hemorrhoid according to claim 7, anal fissure disease, its disinfecting action is sterilizing methods and the ultraviolet sterilizing lamp irradiation that adopts staged to heat up, earlier Radix Notoginseng, Pseudobulbus Bletillae (Rhizoma Bletillae), Cortex Dictamni, Scorpio group medicine are incubated 10 minutes down at 60 ℃, and then be warmed up to 70 ℃ and kept 10 minutes, be warmed up to 75 ℃ again and kept 10 minutes, promptly obtain the powder of this group medicine.Radix Et Rhizoma Rhei, Radix Sophorae Flavescentis group medicine are layered on equably on the thin plate after the sterilization, the average thickness of medicine is 0.5 millimeter again.The irradiation of sterilizing of 3 meters directly over thin plate, the ultraviolet sterilizing lamp of putting a wavelength and be 2,537 , the time is 2 hours, promptly obtains the powder of this group medicine.Two groups of drug powders after the sterilization are made soft gelatin capsule (tablet).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN97110684A CN1188013A (en) | 1997-06-11 | 1997-06-11 | Drug for curing haemorrhoids and anal fissure disease and its preparing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN97110684A CN1188013A (en) | 1997-06-11 | 1997-06-11 | Drug for curing haemorrhoids and anal fissure disease and its preparing method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1188013A true CN1188013A (en) | 1998-07-22 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN97110684A Withdrawn CN1188013A (en) | 1997-06-11 | 1997-06-11 | Drug for curing haemorrhoids and anal fissure disease and its preparing method |
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| Country | Link |
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| CN (1) | CN1188013A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105267294A (en) * | 2014-07-04 | 2016-01-27 | 郭朝军 | Bag clamping technology for pain-free radical treatment of hemorrhoid and hemorrhoid-fistula |
| CN105267316A (en) * | 2014-07-25 | 2016-01-27 | 高晓燕 | Hemorrhoid treating formula |
-
1997
- 1997-06-11 CN CN97110684A patent/CN1188013A/en not_active Withdrawn
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105267294A (en) * | 2014-07-04 | 2016-01-27 | 郭朝军 | Bag clamping technology for pain-free radical treatment of hemorrhoid and hemorrhoid-fistula |
| CN105267316A (en) * | 2014-07-25 | 2016-01-27 | 高晓燕 | Hemorrhoid treating formula |
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| Date | Code | Title | Description |
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| C06 | Publication | ||
| C10 | Entry into substantive examination | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| C03 | Withdrawal of patent application (patent law 1993) | ||
| WW01 | Invention patent application withdrawn after publication |