CN118667012A - Fcrn抗体及其使用方法 - Google Patents

Fcrn抗体及其使用方法 Download PDF

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Publication number
CN118667012A
CN118667012A CN202410661147.9A CN202410661147A CN118667012A CN 118667012 A CN118667012 A CN 118667012A CN 202410661147 A CN202410661147 A CN 202410661147A CN 118667012 A CN118667012 A CN 118667012A
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China
Prior art keywords
sequence
seq
cdr
fcrn
antibody
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CN202410661147.9A
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English (en)
Chinese (zh)
Inventor
M·克里
D·J·金
L·E·凌
J·米多尔三世
S·罗伊
A·曼宁
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Momenta Pharmaceuticals Inc
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Momenta Pharmaceuticals Inc
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Publication of CN118667012A publication Critical patent/CN118667012A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/283—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
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    • A61P5/40—Mineralocorticosteroids, e.g. aldosterone; Drugs increasing or potentiating the activity of mineralocorticosteroids
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    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
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  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Transplantation (AREA)
  • Hospice & Palliative Care (AREA)
CN202410661147.9A 2015-01-30 2016-01-29 Fcrn抗体及其使用方法 Pending CN118667012A (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201562110071P 2015-01-30 2015-01-30
US62/110071 2015-01-30
US201562258082P 2015-11-20 2015-11-20
US62/258082 2015-11-20
CN201680008485.6A CN107567460B (zh) 2015-01-30 2016-01-29 Fcrn抗体及其使用方法
PCT/US2016/015720 WO2016123521A2 (en) 2015-01-30 2016-01-29 Fcrn antibodies and methods of use thereof

Related Parent Applications (1)

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CN201680008485.6A Division CN107567460B (zh) 2015-01-30 2016-01-29 Fcrn抗体及其使用方法

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CN118667012A true CN118667012A (zh) 2024-09-20

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Family Applications (13)

Application Number Title Priority Date Filing Date
CN202410661147.9A Pending CN118667012A (zh) 2015-01-30 2016-01-29 Fcrn抗体及其使用方法
CN202410661131.8A Pending CN118638229A (zh) 2015-01-30 2016-01-29 Fcrn抗体及其使用方法
CN202410661150.0A Pending CN118667014A (zh) 2015-01-30 2016-01-29 Fcrn抗体及其使用方法
CN202110605791.0A Active CN113384693B (zh) 2015-01-30 2016-01-29 Fcrn抗体及其使用方法
CN202410661144.5A Pending CN118562003A (zh) 2015-01-30 2016-01-29 Fcrn抗体及其使用方法
CN201680008485.6A Active CN107567460B (zh) 2015-01-30 2016-01-29 Fcrn抗体及其使用方法
CN202410661133.7A Pending CN118667009A (zh) 2015-01-30 2016-01-29 Fcrn抗体及其使用方法
CN202410661138.XA Pending CN118652337A (zh) 2015-01-30 2016-01-29 Fcrn抗体及其使用方法
CN202410661142.6A Pending CN118667011A (zh) 2015-01-30 2016-01-29 Fcrn抗体及其使用方法
CN202410661152.XA Pending CN118667015A (zh) 2015-01-30 2016-01-29 Fcrn抗体及其使用方法
CN202410661149.8A Pending CN118667013A (zh) 2015-01-30 2016-01-29 Fcrn抗体及其使用方法
CN202410661136.0A Pending CN118638230A (zh) 2015-01-30 2016-01-29 Fcrn抗体及其使用方法
CN202410661140.7A Pending CN118667010A (zh) 2015-01-30 2016-01-29 Fcrn抗体及其使用方法

Family Applications After (12)

Application Number Title Priority Date Filing Date
CN202410661131.8A Pending CN118638229A (zh) 2015-01-30 2016-01-29 Fcrn抗体及其使用方法
CN202410661150.0A Pending CN118667014A (zh) 2015-01-30 2016-01-29 Fcrn抗体及其使用方法
CN202110605791.0A Active CN113384693B (zh) 2015-01-30 2016-01-29 Fcrn抗体及其使用方法
CN202410661144.5A Pending CN118562003A (zh) 2015-01-30 2016-01-29 Fcrn抗体及其使用方法
CN201680008485.6A Active CN107567460B (zh) 2015-01-30 2016-01-29 Fcrn抗体及其使用方法
CN202410661133.7A Pending CN118667009A (zh) 2015-01-30 2016-01-29 Fcrn抗体及其使用方法
CN202410661138.XA Pending CN118652337A (zh) 2015-01-30 2016-01-29 Fcrn抗体及其使用方法
CN202410661142.6A Pending CN118667011A (zh) 2015-01-30 2016-01-29 Fcrn抗体及其使用方法
CN202410661152.XA Pending CN118667015A (zh) 2015-01-30 2016-01-29 Fcrn抗体及其使用方法
CN202410661149.8A Pending CN118667013A (zh) 2015-01-30 2016-01-29 Fcrn抗体及其使用方法
CN202410661136.0A Pending CN118638230A (zh) 2015-01-30 2016-01-29 Fcrn抗体及其使用方法
CN202410661140.7A Pending CN118667010A (zh) 2015-01-30 2016-01-29 Fcrn抗体及其使用方法

Country Status (21)

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US (3) US10676526B2 (https=)
EP (2) EP3250610B1 (https=)
JP (2) JP6853178B2 (https=)
KR (3) KR102792441B1 (https=)
CN (13) CN118667012A (https=)
AU (2) AU2016211280B2 (https=)
DK (1) DK3250610T3 (https=)
ES (1) ES2962824T3 (https=)
FI (1) FI3250610T3 (https=)
HR (1) HRP20231399T1 (https=)
HU (1) HUE063778T2 (https=)
IL (1) IL252837B (https=)
LT (1) LT3250610T (https=)
NZ (1) NZ772383A (https=)
PL (1) PL3250610T3 (https=)
PT (1) PT3250610T (https=)
RS (1) RS64768B1 (https=)
SG (2) SG10202007232WA (https=)
SI (1) SI3250610T1 (https=)
SM (1) SMT202300365T1 (https=)
WO (1) WO2016123521A2 (https=)

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KR20170015920A (ko) * 2014-06-12 2017-02-10 에프. 호프만-라 로슈 아게 ＦｃＲｎ 상호작용이 변화된 항체를 선별하는 방법
RS64768B1 (sr) * 2015-01-30 2023-11-30 Momenta Pharmaceuticals Inc Fcrn antitela i načini njihove upotrebe
SMT202400004T1 (it) * 2016-07-29 2024-03-13 Momenta Pharmaceuticals Inc Anticorpi fcrn e loro metodi di utilizzo
MA49378A (fr) * 2017-06-15 2020-04-22 UCB Biopharma SRL Méthode de traitement de la thrombocytopénie immunitaire
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CN113518783A (zh) * 2018-07-20 2021-10-19 动量制药公司 FcRn抗体组合物
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JP7565951B2 (ja) 2019-06-07 2024-10-11 アルジェニクス ビーブイ 皮下投与に好適なＦｃＲｎインヒビターの医薬製剤
EP4007605A4 (en) * 2019-08-01 2023-08-16 Momenta Pharmaceuticals, Inc. ANTI-FCRN ANTIBODIES AND METHODS OF USE THEREOF
AU2020387399A1 (en) * 2019-11-19 2022-05-19 Immunovant Sciences Gmbh Methods of treating warm autoimmune hemolytic anemia using anti-FcRn antibodies
JP2023509195A (ja) 2020-01-08 2023-03-07 アルジェニクス ビーブイ 天疱瘡症を治療する方法
IL302516A (en) * 2020-11-06 2023-07-01 Janssen Biotech Inc FCRN antibodies and methods of using them
EP4287828A4 (en) * 2021-02-02 2025-01-15 Biocytogen Pharmaceuticals (Beijing) Co., Ltd. Genetically modified non-human animal with human or chimeric fcrn
JP7755725B2 (ja) * 2021-08-13 2025-10-16 ジャンスー バイオジェッテイ バイオテクノロジー カンパニー リミテッド Ｆｃｒｎを特異的に認識する抗体およびその使用
CN116234827A (zh) * 2021-09-03 2023-06-06 舒泰神（北京）生物制药股份有限公司 特异性识别FcRn的抗体及其应用
AU2023281650A1 (en) 2022-05-30 2024-10-17 Hanall Biopharma Co., Ltd. Anti-fcrn antibody or antigen binding fragment thereof with improved stability
CN119698429A (zh) 2022-06-15 2025-03-25 阿根思有限公司 Fcrn结合分子及使用方法
WO2024163894A1 (en) 2023-02-04 2024-08-08 Momenta Pharmaceuticals, Inc. Compositions and methods for treating hemolytic disease of the fetus and newborn
TW202527982A (zh) 2023-09-11 2025-07-16 美商默門塔醫藥公司 Fcrn抗體之醫藥組成物
WO2025099576A1 (en) 2023-11-06 2025-05-15 Momenta Pharmaceuticals, Inc. Compositions and methods for treating rheumatoid arthritis
WO2025163617A1 (en) 2024-02-04 2025-08-07 Momenta Pharmaceuticals, Inc. Compositions and methods for treating sjögren's disease
WO2025186787A1 (en) 2024-03-08 2025-09-12 Momenta Pharmaceuticals, Inc. Compositions and methods for treating fetal and neonatal alloimmune thrombocytopenia
WO2026083290A1 (en) 2024-10-16 2026-04-23 Momenta Pharmaceuticals, Inc. Compositions and methods for treating sjögren's disease

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