CN118660708A - 用于经皮给药的含有rna的组合物和该组合物的给药方法 - Google Patents

用于经皮给药的含有rna的组合物和该组合物的给药方法 Download PDF

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Publication number
CN118660708A
CN118660708A CN202380017975.2A CN202380017975A CN118660708A CN 118660708 A CN118660708 A CN 118660708A CN 202380017975 A CN202380017975 A CN 202380017975A CN 118660708 A CN118660708 A CN 118660708A
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China
Prior art keywords
composition
rna
mrna
gas generating
nucleic acid
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Pending
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CN202380017975.2A
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English (en)
Chinese (zh)
Inventor
片冈一则
内田智士
塞德·阿姆贾德·优素福·阿巴西
正井三贵
林玲匡
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Educational Foundation Kyorin Gakuen
Nanomrna Corp
Public Welfare Consortium Legal Person Kawasaki Industrial Revitalization Consortium
Kyoto Prefectural PUC
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Educational Foundation Kyorin Gakuen
Nanomrna Corp
Public Welfare Consortium Legal Person Kawasaki Industrial Revitalization Consortium
Kyoto Prefectural PUC
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Application filed by Educational Foundation Kyorin Gakuen, Nanomrna Corp, Public Welfare Consortium Legal Person Kawasaki Industrial Revitalization Consortium, Kyoto Prefectural PUC filed Critical Educational Foundation Kyorin Gakuen
Publication of CN118660708A publication Critical patent/CN118660708A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
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    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2046—Media being expelled from injector by gas generation, e.g. explosive charge
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    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/30—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
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    • C12N2770/00011—Details
    • C12N2770/20011—Coronaviridae
    • C12N2770/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/50—Vector systems having a special element relevant for transcription regulating RNA stability, not being an intron, e.g. poly A signal

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  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Virology (AREA)
  • Dermatology (AREA)
  • Plant Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
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  • Heart & Thoracic Surgery (AREA)
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CN202380017975.2A 2022-01-25 2023-01-25 用于经皮给药的含有rna的组合物和该组合物的给药方法 Pending CN118660708A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2022-009172 2022-01-25
JP2022009172 2022-01-25
PCT/JP2023/002184 WO2023145755A1 (ja) 2022-01-25 2023-01-25 経皮投与用のｒｎａを含む組成物および当該組成物の投与方法

Publications (1)

Publication Number Publication Date
CN118660708A true CN118660708A (zh) 2024-09-17

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CN202380017975.2A Pending CN118660708A (zh) 2022-01-25 2023-01-25 用于经皮给药的含有rna的组合物和该组合物的给药方法

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US (1) US20250099577A1 (https=)
EP (1) EP4470543A4 (https=)
JP (1) JPWO2023145755A1 (https=)
CN (1) CN118660708A (https=)
WO (1) WO2023145755A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
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WO2025105251A1 (ja) * 2023-11-14 2025-05-22 株式会社ダイセル 注入器、及び該注入器を用いて対象に溶液を注入する方法
WO2025220620A1 (ja) * 2024-04-15 2025-10-23 国立大学法人東京科学大学 経皮投与用のワクチン組成物および当該ワクチン組成物の投与方法

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Publication number Publication date
EP4470543A1 (en) 2024-12-04
JPWO2023145755A1 (https=) 2023-08-03
WO2023145755A1 (ja) 2023-08-03
EP4470543A4 (en) 2026-04-01
US20250099577A1 (en) 2025-03-27

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