CN118632866A - 结合胸腺基质淋巴细胞生成素的蛋白质z变体及其医疗用途 - Google Patents

结合胸腺基质淋巴细胞生成素的蛋白质z变体及其医疗用途 Download PDF

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Publication number
CN118632866A
CN118632866A CN202380019293.5A CN202380019293A CN118632866A CN 118632866 A CN118632866 A CN 118632866A CN 202380019293 A CN202380019293 A CN 202380019293A CN 118632866 A CN118632866 A CN 118632866A
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CN
China
Prior art keywords
tslp
binding
seq
sequence
binding polypeptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202380019293.5A
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English (en)
Chinese (zh)
Inventor
安娜·爱德沃森
林德维·古德蒙斯多特
西亚瓦什·基贾尼
苏珊娜·柯林特
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Affibody AB
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Affibody AB
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Publication date
Application filed by Affibody AB filed Critical Affibody AB
Publication of CN118632866A publication Critical patent/CN118632866A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN202380019293.5A 2022-02-08 2023-02-08 结合胸腺基质淋巴细胞生成素的蛋白质z变体及其医疗用途 Pending CN118632866A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP22155646 2022-02-08
EP22155646.7 2022-02-08
PCT/EP2023/053030 WO2023152144A1 (en) 2022-02-08 2023-02-08 Protein z variants binding thymic stromal lymphopoietin and their medical use

Publications (1)

Publication Number Publication Date
CN118632866A true CN118632866A (zh) 2024-09-10

Family

ID=80682629

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202380019293.5A Pending CN118632866A (zh) 2022-02-08 2023-02-08 结合胸腺基质淋巴细胞生成素的蛋白质z变体及其医疗用途

Country Status (10)

Country Link
EP (1) EP4476247A1 (https=)
JP (1) JP2025506381A (https=)
KR (1) KR20240139058A (https=)
CN (1) CN118632866A (https=)
AR (1) AR128475A1 (https=)
AU (1) AU2023218534A1 (https=)
CA (1) CA3251231A1 (https=)
IL (1) IL314458A (https=)
MX (1) MX2024009732A (https=)
WO (1) WO2023152144A1 (https=)

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2190863B1 (en) 2007-07-31 2015-09-02 Affibody AB New albumin binding compositions, methods and uses
ES2373832T3 (es) 2007-12-19 2012-02-09 Affibody Ab Polipéptido derivado de proteína a y capaz de unirse a pdgf.
CN103003296A (zh) 2010-07-09 2013-03-27 阿菲博迪公司 多肽
WO2014048977A1 (en) 2012-09-25 2014-04-03 Affibody Ab Albumin binding polzpeptide
KR102399024B1 (ko) 2014-06-13 2022-05-17 애피바디 에이비 신규 폴리펩티드
EP3245224B1 (en) * 2015-01-12 2020-07-15 Affibody AB Il-17a-binding polypeptides
CN108290931A (zh) 2015-10-30 2018-07-17 阿菲博迪公司 对pd-l1具有亲和力的新的多肽
WO2021089695A1 (en) * 2019-11-05 2021-05-14 Affibody Ab Polypeptides

Also Published As

Publication number Publication date
AR128475A1 (es) 2024-05-15
JP2025506381A (ja) 2025-03-11
WO2023152144A1 (en) 2023-08-17
CA3251231A1 (en) 2023-08-17
EP4476247A1 (en) 2024-12-18
KR20240139058A (ko) 2024-09-20
MX2024009732A (es) 2024-08-19
IL314458A (en) 2024-09-01
AU2023218534A1 (en) 2024-07-11

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