CA3251231A1 - Variants of protein Z binding to thymic stromal lymphopoietin and their medical use - Google Patents

Variants of protein Z binding to thymic stromal lymphopoietin and their medical use

Info

Publication number
CA3251231A1
CA3251231A1 CA3251231A CA3251231A CA3251231A1 CA 3251231 A1 CA3251231 A1 CA 3251231A1 CA 3251231 A CA3251231 A CA 3251231A CA 3251231 A CA3251231 A CA 3251231A CA 3251231 A1 CA3251231 A1 CA 3251231A1
Authority
CA
Canada
Prior art keywords
tslp
seq
sequence
binding
binding polypeptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3251231A
Other languages
English (en)
French (fr)
Inventor
Anna EDVARDSSON
Lindvi Gudmundsdotter
Siavash KIJANI
Susanne Klint
Original Assignee
Affibody AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Affibody AB filed Critical Affibody AB
Publication of CA3251231A1 publication Critical patent/CA3251231A1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CA3251231A 2022-02-08 2023-02-08 Variants of protein Z binding to thymic stromal lymphopoietin and their medical use Pending CA3251231A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP22155646 2022-02-08
EP22155646.7 2022-02-08
PCT/EP2023/053030 WO2023152144A1 (en) 2022-02-08 2023-02-08 Protein z variants binding thymic stromal lymphopoietin and their medical use

Publications (1)

Publication Number Publication Date
CA3251231A1 true CA3251231A1 (en) 2023-08-17

Family

ID=80682629

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3251231A Pending CA3251231A1 (en) 2022-02-08 2023-02-08 Variants of protein Z binding to thymic stromal lymphopoietin and their medical use

Country Status (10)

Country Link
EP (1) EP4476247A1 (https=)
JP (1) JP2025506381A (https=)
KR (1) KR20240139058A (https=)
CN (1) CN118632866A (https=)
AR (1) AR128475A1 (https=)
AU (1) AU2023218534A1 (https=)
CA (1) CA3251231A1 (https=)
IL (1) IL314458A (https=)
MX (1) MX2024009732A (https=)
WO (1) WO2023152144A1 (https=)

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2190863B1 (en) 2007-07-31 2015-09-02 Affibody AB New albumin binding compositions, methods and uses
ES2373832T3 (es) 2007-12-19 2012-02-09 Affibody Ab Polipéptido derivado de proteína a y capaz de unirse a pdgf.
CN103003296A (zh) 2010-07-09 2013-03-27 阿菲博迪公司 多肽
WO2014048977A1 (en) 2012-09-25 2014-04-03 Affibody Ab Albumin binding polzpeptide
KR102399024B1 (ko) 2014-06-13 2022-05-17 애피바디 에이비 신규 폴리펩티드
EP3245224B1 (en) * 2015-01-12 2020-07-15 Affibody AB Il-17a-binding polypeptides
CN108290931A (zh) 2015-10-30 2018-07-17 阿菲博迪公司 对pd-l1具有亲和力的新的多肽
WO2021089695A1 (en) * 2019-11-05 2021-05-14 Affibody Ab Polypeptides

Also Published As

Publication number Publication date
AR128475A1 (es) 2024-05-15
JP2025506381A (ja) 2025-03-11
WO2023152144A1 (en) 2023-08-17
EP4476247A1 (en) 2024-12-18
KR20240139058A (ko) 2024-09-20
MX2024009732A (es) 2024-08-19
IL314458A (en) 2024-09-01
AU2023218534A1 (en) 2024-07-11
CN118632866A (zh) 2024-09-10

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