CN118510888A - 通过微流体递送来产生增强的肿瘤浸润性淋巴细胞的方法 - Google Patents

通过微流体递送来产生增强的肿瘤浸润性淋巴细胞的方法 Download PDF

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Publication number
CN118510888A
CN118510888A CN202280088123.8A CN202280088123A CN118510888A CN 118510888 A CN118510888 A CN 118510888A CN 202280088123 A CN202280088123 A CN 202280088123A CN 118510888 A CN118510888 A CN 118510888A
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China
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til
cytokine
nucleic acid
modified
fold
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CN202280088123.8A
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Chinese (zh)
Inventor
M·F·马洛尼
E·I·奥扎伊
S·M·洛赫德
R·J·希尔弗
A·布拉特
M·希尔瓦
J·B·吉尔伯特
D·布里根
C·J·查尔霍弗
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Stemcell Technologies Canada Inc
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Stemcell Technologies Canada Inc
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Publication of CN118510888A publication Critical patent/CN118510888A/zh
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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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CN202280088123.8A 2021-11-11 2022-11-14 通过微流体递送来产生增强的肿瘤浸润性淋巴细胞的方法 Pending CN118510888A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163278447P 2021-11-11 2021-11-11
US63/278,447 2021-11-11
PCT/US2022/079843 WO2023087009A1 (en) 2021-11-11 2022-11-14 Methods to generate enhanced tumor infiltrating lymphocytes through microfluidic delivery

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CN118510888A true CN118510888A (zh) 2024-08-16

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CN202280088123.8A Pending CN118510888A (zh) 2021-11-11 2022-11-14 通过微流体递送来产生增强的肿瘤浸润性淋巴细胞的方法

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US (1) US20250043244A1 (https=)
EP (1) EP4430168A1 (https=)
JP (1) JP2024545582A (https=)
CN (1) CN118510888A (https=)
WO (1) WO2023087009A1 (https=)

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107058101B (zh) 2011-10-17 2021-06-01 麻省理工学院 细胞内传递
EP3033184B1 (en) 2013-08-16 2021-03-31 Massachusetts Institute of Technology Selective delivery of material to cells
JP7523203B2 (ja) 2014-10-31 2024-07-26 マサチューセッツ インスティテュート オブ テクノロジー 生体分子の免疫細胞への送達
SG10201912910PA (en) 2015-07-09 2020-02-27 Massachusetts Inst Technology Delivery of materials to anucleate cells
ES2930017T3 (es) 2015-09-04 2022-12-05 Sqz Biotechnologies Co Suministro intracelular de biomoléculas mediado por una superficie con poros
JP7602702B2 (ja) 2016-05-03 2024-12-19 ステムセル テクノロジーズ カナダ インコーポレーテッド 寛容性を誘導するための生体分子の細胞内送達
KR102490952B1 (ko) 2016-05-03 2023-01-19 에스큐지 바이오테크놀로지스 컴퍼니 관용을 유도하는 생체분자의 세포내 전달
EP3765068A2 (en) 2018-03-12 2021-01-20 SQZ Biotechnologies Company Intracellular delivery of biomolecules to modify immune response
US12599656B2 (en) 2018-03-12 2026-04-14 Stemcell Technologies Canada Inc. Methods for treating HPV-associated diseases
KR20210070338A (ko) 2018-10-04 2021-06-14 에스큐지 바이오테크놀로지스 컴퍼니 항원 제시 세포 기능을 증진시키기 위한 생체분자의 세포내 전달
WO2020154696A1 (en) 2019-01-25 2020-07-30 Sqz Biotechnologies Company Anucleate cell-derived vaccines
CA3131701A1 (en) 2019-02-28 2020-09-03 Sqz Biotechnologies Company Delivery of biomolecules to pbmcs to modify an immune response
CA3150224A1 (en) * 2019-09-10 2021-03-18 Obsidian Therapeutics, Inc. Ca2 compositions and methods for tunable regulation
AU2020355025A1 (en) * 2019-09-23 2022-04-07 Regents Of The University Of Minnesota Genetically-edited immune cells and methods of therapy
TW202241508A (zh) * 2021-01-29 2022-11-01 美商艾歐凡斯生物治療公司 細胞介素相關之腫瘤浸潤性淋巴球組合物及方法
WO2023010090A1 (en) * 2021-07-29 2023-02-02 Sqz Biotechnologies Company Methods to generate enhanced tumor infiltrating lymphocytes through microfluidic delivery

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WO2023087009A1 (en) 2023-05-19
EP4430168A1 (en) 2024-09-18
JP2024545582A (ja) 2024-12-10
US20250043244A1 (en) 2025-02-06

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