CN118480560A - 呼吸道合胞病毒mRNA疫苗及其制备方法和应用 - Google Patents

呼吸道合胞病毒mRNA疫苗及其制备方法和应用 Download PDF

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CN118480560A
CN118480560A CN202410911569.7A CN202410911569A CN118480560A CN 118480560 A CN118480560 A CN 118480560A CN 202410911569 A CN202410911569 A CN 202410911569A CN 118480560 A CN118480560 A CN 118480560A
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宋更申
董开
潘晨
汪王
周玉婷
柴欣
李静
朗晓威
张晋瑜
梁丽敏
王环宇
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Abstract

本发明属于mRNA疫苗技术领域，尤其涉及呼吸道合胞病毒RSV疫苗及其制备方法和应用。本发明提供的RSV疫苗，含编码RSV F蛋白或其变体的RNA。所述疫苗能预防RSV感染及其并发症。

Description

呼吸道合胞病毒mRNA疫苗及其制备方法和应用
技术领域
本公开属于核酸疫苗技术领域，具体涉及一种呼吸道合胞病毒mRNA疫苗及其制备方法和应用。
背景技术
呼吸道合胞病毒（Respiratory syncytial virus，RSV）是一种副黏病毒科肺炎病毒属的负单链RNA病毒。1956年科学家从黑猩猩呼吸道标本分离出RSV病毒，因其在细胞培养过程中导致相邻细胞融合，细胞变形成类似合胞体的结构而被称为呼吸道合胞病毒。
RSV病毒是引起婴幼儿、老年人及免疫功能缺陷患者下呼吸道感染的重要病原体。RSV由空气传播，通过口鼻吸入进入气管和肺部，侵入上皮细胞导致气道损伤，气道表面分泌呼吸道粘液阻塞管腔，引起呼吸困难。RSV感染的常见症状是流涕、发热、咳嗽和哮喘，病情严重后会引发呼吸窘迫甚至造成气道堵塞，从而引起呼吸衰竭甚至死亡。
RSV是一种常见的呼吸道病毒。一般会引起感冒样症状，RSV感染主要发生在秋季、冬季和春季，是导致5 岁以下婴幼儿和65 岁以上老年人感染严重呼吸道疾病的主因之一。对绝大多数青年人而言，RSV通常会引起轻微的、类似感冒的症状，但对婴幼儿和老年人而言，RSV感染则是一种可以致命的疾病。
RSV感染已成为世界性公共卫生问题。RSV是世界范围内引起5岁以下儿童急性下呼吸道感染（Acute lower respiratory tract infections, ALRTI）最常见的病毒病原，是造成婴幼儿病毒性呼吸道感染住院的首要因素。有数据显示，RSV感染占所有ALRTI的28%，其中RSV住院死亡患儿占ALRTI导致死亡病例的13%-22%。。
RSV感染呈全球性广泛流行特征，且流行受地理位置、温度和湿度等因素影响。例如我国北方地区RSV流行季开始于10月中旬至次年5月中旬，南方地区冬春季好发，与温度密切相关。RSV只有一个血清型，分为A、B两个亚型，我国北方呈交替流行趋势。
疫苗是预防RSV感染最经济、最有效的防治措施。WHO将RSV疫苗的研制列为急迫需要解决的问题之一。但是RSV疫苗的研制工作自上世纪60年代开展至今，一直没有监管机构认证的有效疫苗获批上市。最近RSV疫苗相继取得重大突破。2023年5月3日，GSK研发的呼吸道合胞病毒（RSV）疫苗Arexvy获 FDA 的上市批准，成为全球首款获批上市的 RSV 疫苗。该疫苗主要用于60岁及以上患者，预防 RSV 感染导致的下呼吸道（支气管及肺部）疾病。随后在2023年6月1日，美国FDA又批准辉瑞的RSV蛋白疫苗AbrysvoTM上市，用于预防60岁及以上成人由RSV引起的急性呼吸道疾病和下呼吸道疾病。
目前在研的RSV疫苗技术路线有减毒活疫苗、亚单位疫苗、重组载体疫苗、mRNA疫苗等。传统疫苗通常基于灭活或减毒活病毒疫苗，或来源于病原体的亚单位蛋白。虽然这些疫苗产生有效的免疫反应，但它们有许多相关的安全问题。例如，早期开发的RSV灭活疫苗不但没有对接种者产生保护作用，反而出现了疾病增强作用（ERD），即不但不能预防接种者感染RSV病毒，而且还会导致接种者感染RSV后病情加重。在一项RSV灭活疫苗临床试验中，试验组的20个婴儿中出现16个病情严重而且需要住院治疗, 住院率高达80%，其中还有两个婴儿死亡。
mRNA疫苗是将编码病毒抗原的mRNA导入体内并在机体内表达产生抗原，继而刺激体内产生免疫反应，因mRNA仅存在于细胞质而不会整合到宿主基因组中且可以体内自然降解，因而安全性较高。mRNA疫苗本身可以作为佐剂诱导机体产生天然免疫效应，而且mRNA疫苗能诱导很强的体液免疫和细胞免疫，一般具有比传统灭活疫苗和亚单位蛋白疫苗更强的免疫效果。mRNA疫苗不需要与其他疫苗佐剂联合使用，因此可减少由其他物质引起的不良反应。与传统疫苗相比，mRNA疫苗生产工艺流程相对简单，研发周期短，对新发突发传染病疫苗研发具有快速响应的技术优势。mRNA疫苗在新冠病毒疫苗研发中取得了成功，通过大规模人群接种证明了mRNA疫苗技术的安全性和有效性。
RSV感染引起的中和抗体主要针对F蛋白。RSV F蛋白是一种Ⅰ型融合糖蛋白，在RSV各型别之间相对保守，是理想的疫苗抗原靶蛋白。 F蛋白在两个构象之间转换：亚稳态的融合前构象（pre-F）和稳态的融合后构象(post-F)。尽管中和抗体靶向的抗原表位存在于F蛋白两种构象上，但人类对RSV感染的自然免疫应答特征表明，大多数RSV中和抗体表位位于F蛋白融合前构象。由于F蛋白融合前构象具有不稳定性，因此基于RSV灭活疫苗或直接从RSV中提取的F蛋白亚单位疫苗均以失败告终。
基于上述问题，为了进一步降低免疫力低下人群（包括儿童和老人等）罹患呼吸道合胞病毒的风险，亟待提供一种新型的预防RSV的 mRNA疫苗，其具有良好的稳定性，并且接种疫苗后能显著提升体液免疫效果。
发明内容
本发明提供了一种编码RSV F蛋白尤其是F蛋白融合前构象pre-F的mRNA疫苗，RSVA2亚型的野生蛋白序列示于SEQ ID NO：1（GenBank ID：138251），在此野生型基础上包含P102A、I379V和M447V共3个天然存在的突变（SEQ ID NO:210），该三个氨基酸残基突变后的序列在其它RSV A毒株中保守，综合考虑目前主流毒株F蛋白序列的差异，在其基础上设计候选突变抗原序列。
RSV病毒包括亚型A和B，其F蛋白的氨基酸序列约90%相同。对于A亚型的F0前体多肽的序列，例如A2毒株(GenBank GI：138251；Swiss Prot P03420)，以及B亚型的F0前体多肽的序列，例如，18537毒株(GenBank GI：138250；Swiss Prot P13843)，两者都是574个氨基酸的序列，并且二者的信号肽序列也已报道为氨基酸1-25 (GenBank和UniProt)。在两个序列中，由于RSV病毒A型和B型二者的F蛋白序列的同源性高，因此本发明设计的RSV pre-FmRNA及其制备的疫苗对RSV病毒A型和B型感染预防均有效。
如本文所述，使用pre-F的三维结构作为指导，工程改造并构建融合前F蛋白的稳定化形式 (“pre-F”抗原)，并且在动物模型中用于产生RSV中和免疫反应，所述免疫反应相比于AbrysvoTM基于RSV F蛋白的免疫原所实现的免疫反应具有显著提高，并且其在动物模型中提供针对RSV激发的保护。所述pre-F抗原可以用作RSV的潜在疫苗和用作诊断分子。
在一些实施方案中，所述重组RSV F蛋白包含一个或更多个氨基酸替换，所述氨基酸替换将所述蛋白稳定在融合前构象。例如，其将所述F蛋白的膜远端部分 (包含F1多肽的N端区域) 稳定在融合前构象。在特异性结合于一种或多种融合前构象抗体和/或呈现存在于RSV F蛋白的融合前而非融合后构象上的抗原位点如抗原位点Φ的构象中。
在另一些实施方案中，所述重组RSV F蛋白可包含对F1多肽的C端的一种或更多种修饰(例如截短和氨基酸替换)，这些修饰与稳定化F多肽的膜远端区域的修饰一起，可以增加所述重组F蛋白在融合前构象中的稳定化。
本申请涉及以下实施方案：
1. 一种免疫原性组合物，包含呼吸道合胞病毒（RSV）的核糖核酸（RNA），所述RNA编码野生型RSV F蛋白或其变体；
其中所述野生型RSV F蛋白的序列为SEQ ID NO:1。
2. 如实施方案1所述的组合物，其中所述RSV F蛋白变体包含选自以下的一种或更多种突变形式：序列截短、序列缺失和位点突变。
3. 如实施方案2所述的组合物，其中，所述序列截短包括缺少细胞质结构域，例如所述序列截短为截掉RSV F蛋白C端550-574位氨基酸，例如相对于野生型F蛋白，所述截短即保留RSV F蛋白的1-549位氨基酸。
4. 如实施方案2或3所述的组合物，其中，所述序列缺失选自以下一种或更多种：第104-136位氨基酸缺失和104-144位氨基酸缺失；任选地，所述序列缺失的氨基酸由GSGS短肽或GS短肽替代。
5. 如实施方案2至4中任一项所述的组合物，其中，所述位点突变包括选自以下的一种或更多种：P102A、I379V和M447V，例如，所述位点突变包括P102A和I379V；P102A和M447V；I379V和M447V；P102A、I379V和M447V。
6. 如实施方案5所述的组合物，其中，所述位点突变还包括选自以下的一种或更多种：S46G、S215P、L373R、S213P和N216P，例如选自以下的位点突变：S46G、S215P和L373R。
7. 如实施方案5或6所述的组合物，其中，所述位点突变还包括选自以下的一种或更多种：
(i) Q26C、N27C、T29C、E31C、F32C、Q34C、T36C、S41C、Y44C、Y53C、T54C、S55C、T100C、T103C、L138C、G139C、F140C、L141C、L142C、G145C、S146C、A147C、I148C、A149C、S150C、V152C、A153C、V154C、S155C、N183GC、S186C、L188C、S287C、I288C、S290C、I291C、I292C、V300C、L305C、Y306C、S319C、N325C、S330C、T337C、R339C、Q354C、T369C、M370C、N371C、S377C、N428C、Y458C、K461C、Q462C、K465C、L467C、Y468C、K470C、G471C；
(ii) T54H、T58L、S190I、S190F、V207L、T219I、V296I；
(iii) E92D、K465Q、D486S；和
(iv) V152I、C69Y、D73E、A74V、N88S。
8. 如实施方案5或6所述的组合物，其中，所述位点突变还包括选自以下的一个或更多个组合：
(i) E31C、Q34C、T54C、S55C、T100C、I148C、A149C、V152C、V154C、S155C、L188C、I288C、S290C、R339C、S377C、Y458C、L467C、G471C；
(ii) S190F、V296I、V207L、T219I、S190I；
(iii) E92D、K465Q、D486S；和
(iv) V152I、C69Y、D73E、A74V、N88S。
9. 如实施方案5或6所述的组合物，其中，所述位点突变还包括选自以下的一个或更多个组合：
(i) T54C、S55C、T100C、I148C、A149C、V152C、V154C、S155C、L188C、I288C、S290C、R339C、S377C、Y458C；
(ii) S190F、V296I、V207L、T219I、S190I；
(iii) E92D、K465Q、D486S；和
(iv) V152I、C69Y、D73E、A74V、N88S。
10. 如实施方案5或6所述的组合物，其中，所述位点突变还包括选自以下的一个或更多个组合：
(i) T54C、I148C、A149C、V152C、S155C、I288C、S290C、Y458C；
(ii) S190F、V296I、V207L；
(iii) E92D、K465Q、D486S；和
(iv) V152I、C69Y、D73E、A74V、N88S。
11. 如实施方案1至10中任一项所述的组合物，其中，所述RSV F蛋白变体包含P102A、I379V和M447V突变，所述RSV F蛋白变体为SEQ ID NO:1中第550-574位氨基酸被截掉后的截短蛋白，并且第104-144位氨基酸被替换为GS接头，同时所述RSV F蛋白变体还包含选自以下任意一组的位点突变组合：
。
12. 如实施方案1至10任一项所述的组合物，其中，所述RSV F蛋白变体包含P102A、I379V和M447V突变，所述RSV F蛋白变体为SEQ ID NO:1中第550-574位氨基酸被截掉后的截短蛋白，并且第104-144位氨基酸被替换为GS 接头，同时所述RSV F蛋白变体还包含选自以下任意一组位点突变组合：
。
13. 如实施方案1至10任一项所述的组合物，其中，所述RSV F蛋白变体包含P102A、I379V和M447V突变，所述RSV F蛋白变体为SEQ ID NO:1中第550-574位氨基酸被截掉后的截短蛋白，并且第104-144位氨基酸被替换为GS 接头，同时所述RSV F蛋白变体还包含选自以下任意一组的突变组合：
。
14. 如实施方案1至13中任一项所述的组合物，其中，所述RSV F蛋白的变体包含与SEQ ID NO: 204（YK-RSV-061）、SEQ ID NO: 12（YK-RSV-003）、SEQ ID NO: 208（YK-RSV-062）、SEQ ID NO: 176（YK-RSV-054）、SEQ ID NO: 116（YK-RSV-039）、SEQ ID NO: 136（YK-RSV-044）、SEQ ID NO: 40（YK-RSV-012）、SEQ ID NO: 52（YK-RSV-015）、SEQ ID NO: 4（YK-RSV-001）、SEQ ID NO: 104（YK-RSV-036）、SEQ ID NO: 200（YK-RSV-060）、SEQ ID NO: 36（YK-RSV-011）或SEQ ID NO: 80（YK-RSV-030）的序列具有至少80%、85%、90%、95%或至少98%或100%同一性的氨基酸序列。
15. 如实施方案14所述的组合物，其中，所述RSV F蛋白的变体包含与SEQ ID NO:204（YK-RSV-061）、SEQ ID NO: 12（YK-RSV-003）、SEQ ID NO: 208（YK-RSV-062）、SEQ IDNO: 176（YK-RSV-054）、SEQ ID NO: 116（YK-RSV-039）、SEQ ID NO: 136（YK-RSV-044）、SEQID NO: 40（YK-RSV-012）、SEQ ID NO: 52（YK-RSV-015）、SEQ ID NO: 4（YK-RSV-001）、SEQID NO: 104（YK-RSV-036）或SEQ ID NO: 200（YK-RSV-060）的序列具有至少80%、85%、90%、95%或至少98%或100%同一性的氨基酸序列。
16. 如实施方案15所述的组合物，其中，所述RSV F蛋白的变体包含与SEQ ID NO:204（YK-RSV-061）、SEQ ID NO: 12（YK-RSV-003）、SEQ ID NO: 208（YK-RSV-062）、SEQ IDNO: 176（YK-RSV-054）或SEQ ID NO: 116（YK-RSV-039）的序列具有至少80%、85%、90%、95%或至少98%或100%同一性的氨基酸序列。
17. 如实施方案1至16中任一项所述的组合物，其中，编码所述RSV F蛋白或其变体的开放阅读框（ORF）包含与SEQ ID NO: 203、SEQ ID NO:11、SEQ ID NO:207、SEQ ID NO:175、SEQ ID NO:115、SEQ ID NO:135、SEQ ID NO:39、SEQ ID NO:51、SEQ ID NO:3、SEQ IDNO:103、SEQ ID NO:199、SEQ ID NO:35或SEQ ID NO:79具有至少80%、85%、90%、95%或至少98%或100%同一性的核苷酸序列。
18. 如实施方案17所述的组合物，其中，所述ORF包含与SEQ ID NO: 203、SEQ IDNO:11、SEQ ID NO:207、SEQ ID NO:175、SEQ ID NO:115、SEQ ID NO:135、SEQ ID NO:39、SEQ ID NO:51、SEQ ID NO:3、SEQ ID NO:103或SEQ ID NO:199具有至少80%、85%、90%、95%或至少98%或100%同一性的核苷酸序列。
19. 如实施方案18所述的组合物，其中，所述ORF包含与SEQ ID NO: 203、SEQ IDNO:11、SEQ ID NO:207、SEQ ID NO:175或SEQ ID NO:115具有至少80%、85%、90%、95%或至少98%或100%同一性的核苷酸序列。
20. 如实施方案1至19中任一项所述的组合物，其中，所述RSV的RNA还包含5′非翻译区（UTR）。
21. 如实施方案20所述的组合物，其中所述5′UTR的序列为：SEQ ID NO:217、SEQID NO:218、SEQ ID NO:219、SEQ ID NO:220或SEQ ID NO:221。
22. 如实施方案21所述的组合物，其中所述5′UTR的序列为SEQ ID NO:217。
23. 如实施方案1至22中任一项所述的组合物，其中，所述RSV的RNA还包含3′非翻译区（UTR）。
24. 如实施方案23所述的组合物，其中，所述3′UTR的序列为：SEQ ID NO:222、SEQID NO:223、SEQ ID NO:224或SEQ ID NO:225。
25. 如实施方案24所述的组合物，其中，所述3′UTR的序列为SEQ ID NO:222。
26. 如实施方案1至25中任一项所述的组合物，其中，所述RSV的RNA还包含poly(A)尾。
27. 如实施方案26所述的组合物，其中，所述Ploy(A)尾的长度为50~150个核苷酸。
28. 如实施方案1至27中任一项所述的组合物，其中，所述RSV的RNA还包含5′端帽子结构。
29. 如实施方案28所述的组合物，其中，所述5′端帽子结构为：7mG(5′)ppp(5′)NlmpNp。
30. 如实施方案1至29中任一项所述的组合物，其中，所述RSV RNA中编码所述RSVF蛋白或其变体的开放阅读框（ORF）的序列是经过密码子优化的。
31. 如实施方案30所述的组合物，其中，所述ORF的序列包含至少一种碱基修饰。
32. 如实施方案31所述的组合物，其中，所述碱基修饰包括选自以下的任意一种或更多种：假尿苷、N1-甲基假尿苷、N1-乙基假尿苷、2-硫尿苷、4′-硫尿苷、5-甲基胞嘧啶、2-硫基-1-甲基-1-去氮杂-假尿苷、2-硫基-1-甲基-假尿苷、2-硫基-5-氮杂-尿苷、2-硫基-二氢假尿苷、2-硫基-二氢尿苷、2-硫基-假尿苷、4-甲氧基-2-硫基-假尿苷、4-甲氧基-假尿苷、4-硫基-1-甲基-假尿苷、4-硫基-假尿苷、5-氮杂-尿苷、二氢假尿苷、5-甲氧基尿苷和2′-O-甲基尿苷。
33. 如实施方案32所述的组合物，其中，所述碱基修饰包括将尿嘧啶以假尿苷和/或N1-甲基假尿苷替代。
34. 如实施方案31所述的组合物，其中，所述碱基修饰是1~100%碱基修饰，例如为100%碱基修饰。
35. 如实施方案1至34中任一项所述的组合物，其中，所述RSV的RNA的序列与SEQID NO: 205、SEQ ID NO:13、SEQ ID NO:209、SEQ ID NO:177、SEQ ID NO:117、SEQ ID NO:137、SEQ ID NO:41、SEQ ID NO:53、SEQ ID NO:5、SEQ ID NO:105、SEQ ID NO:201、SEQ IDNO:37或SEQ ID NO:81具有至少80%、85%、90%、95％或至少98％或100%的同一性。
36 .如实施方案35所述的组合物，其中，所述RSV的RNA的序列与SEQ ID NO: 205、SEQ ID NO:13、SEQ ID NO:209、SEQ ID NO:177、SEQ ID NO:117、SEQ ID NO:137、SEQ IDNO:41、SEQ ID NO:53、SEQ ID NO:5、SEQ ID NO:105或SEQ ID NO:201具有至少80%、85%、90%、95％或至少98%或100%的同一性。
37. 如实施方案36所述的组合物，其中，所述RSV的RNA的序列与SEQ ID NO: 205、SEQ ID NO:13、SEQ ID NO:209、SEQ ID NO:177或SEQ ID NO:117具有至少80%、85%、90%、95%或至少98%或100%的同一性。
38. 如实施方案1至37中任一项所述的组合物，其中，所述RSV的RNA为mRNA。
39. 如实施方案1至38中任一项所述的组合物，其中，编码所述RSV F蛋白或其变体的序列与SEQ ID NO: 202、SEQ ID NO:10、SEQ ID NO:206、SEQ ID NO:174、SEQ ID NO:114、SEQ ID NO:134、SEQ ID NO:38、SEQ ID NO:50、SEQ ID NO:2、SEQ ID NO:102、SEQ IDNO:198、SEQ ID NO:34或SEQ ID NO:78具有至少80%、85%、90%、95%或至少98%或100%的同一性。
40. 如实施方案39所述的组合物，其中，编码所述RSV F蛋白或其变体的序列与SEQ ID NO: 202、SEQ ID NO:10、SEQ ID NO:206、SEQ ID NO:174、SEQ ID NO:114、SEQ IDNO:134、SEQ ID NO:38、SEQ ID NO:50、SEQ ID NO:2、SEQ ID NO:102或SEQ ID NO:198具有至少80%、85%、90%、95%或至少98%或100%的同一性。
41. 如实施方案40所述的组合物，其中，编码所述RSV F蛋白或其变体的序列与SEQ ID NO: 202、SEQ ID NO:10、SEQ ID NO:206、SEQ ID NO:174或SEQ ID NO:114具有至少80%、85%、90%、95％或至少98％或100%的同一性。
42. 制备如实施方案1至41中任一项所述组合物的方法，包括：
提供可转录出所述RSV之RNA的模板；
在适于转录所述RNA的条件下，利用所述模板进行转录。
43. 根据实施方案42所述的方法，其还包括选自以下的纯化步骤：氯化锂沉淀、亲和层析、超滤换液、纤维素层析。
44. 根据实施方案1至41中任一项所述的组合物，其是疫苗，并且还包含可药用载剂。
45. 如实施方案44所述的组合物，其中，所述可药用载剂包含脂质混合物，所述脂质混合物例如为脂质纳米颗粒（LNP）。
46. 如实施方案44或45所述的组合物，其中，所述疫苗为mRNA疫苗。
47. 如实施方案45所述的组合物，其中，所述脂质纳米颗粒例如包含阳离子脂质、中性脂质、结构性脂质和聚合物共轭脂质。
48. 如实施方案47所述的组合物，其中，所述阳离子脂质是式I结构的化合物，或其N-氧化物、溶剂合物、药学上可接受的盐或立体异构体，其中G1为C1～6亚烷基；G2为C2～8亚烷基；G3为C1～3亚烷基；L1为C6～15直链烷基；L2为C12～25支链烷基；
例如式I-I结构的YK-009：
。
49. 如实施方案47所述的组合物，其中，所述阳离子脂质是式II结构的化合物，或其N-氧化物、溶剂合物、药学上可接受的盐或立体异构体，其中G1为C2~8亚烷基；G2为C2~8亚烷基；L1为-C(O)O-或-OC(O)-；L2为-C(O)O-或-OC(O)-；R1为C6~25直链或支链烷基；R2为C6~25直链或支链烷基；G3为HO(CH2)2-或HO(CH2)3-；G4为HO(CH2)2-或HO(CH2)3-；L为(CH2)2-或-(CH2)3-或-(CH2)4-；
例如式II-I结构的YK-401或式II-II结构的YK-402：
。
50. 如实施方案47所述的组合物，其中，所述阳离子脂质是式III结构的化合物，或其N-氧化物、溶剂合物、药学上可接受的盐或立体异构体，其中G1为C1~6亚烷基；G2为C2~8亚烷基；R1为C6~20直链或支链烷基；R2为C12~25支链烷基；G3为：HO(CH2)2N(CH3)(CH2)2-，HO(CH2)2N(CH2CH3)(CH2)2-，(HO(CH2)2)2N(CH2)2-，CH3O(CH2)2N(CH3)(CH2)2-，(CH3)2N(CH2)3SC(O)O(CH2)2-，(CH3)2N(CH2)3SC(O)-，CH3NH(CH2)2N(CH3)(CH2)2-或CH3CH2NH(CH2)2-；
例如式III-I结构的YK-201或式III-II结构的YK-202：
。
51. 如实施方案47所述的组合物，其中，所述阳离子脂质是式IV结构的化合物，或其N-氧化物、溶剂合物、药学上可接受的盐或立体异构体，其中G1为C1~8亚烷基；G2为C2~8亚烷基；R1为C6~25直链或支链烷基；R2为C12~25直链或支链烷基；G3为HO(CH2)2N(R3)CH2CH(OH)CH2-，其中R3为-CH3或-CH2CH3或-CH2CH2OH；
例如式IV-I结构的YK-305或式IV-II结构的YK-310：
。
52. 如实施方案47所述的组合物，其中，所述阳离子脂质是式V结构的化合物，或其N-氧化物、溶剂合物、药学上可接受的盐或立体异构体，其中，G1和G2各自独立地为未取代的C6-C10亚烷基；G3为未取代的C1-C12亚烷基；R1和R2各自独立地为C6-C24烷基或C6-C24烯基；R3为OR5、N、-C(＝O)OR4、-OC(＝O)R4或-NR5C(＝O)R4；R4为C1-C12烃基；并且R5为H或C1-C6烷基；
例如式V-I结构的ALC0315：
。
53. 如实施方案47所述的组合物，其中，所述阳离子脂质是式VI结构的化合物，或其N-氧化物、溶剂合物、药学上可接受的盐或立体异构体，其中，R4选自-(CH2)nQ和-(CH2)nCHQR；Q选自由以下组成的组：-OR、-OH、-O(CH2)nN(R)2、-OC(O)R、-CX3、-CN、-N(R)C(O)R、-N(H)C(O)R、-N(R)S(O)2R、-N(H)S(O)2R、-N(R)C(O)N(R)2、-N(H)C(O)N(R)2、-N(H)C(O)N(H)(R)、-N(R)C(S)N(R)2、-N(H)C(S)N(R)2、-N(H)C(S)N(H)(R)、-N(R)S(O)2R8和杂环；n是1、2或3；其中R为氢、C1~3烷基、C2~3烯基或(CH2)qOR*，其中q为1、2或3，R*为C1~12烷基或C2~12烯基；X为氟、氯、溴或碘；R8为C3~6环烷基或杂环；
例如式VI-I结构的SM102
。
54. 如实施方案47所述的组合物，其中，所述阳离子脂质是式VII结构的化合物，或其N-氧化物、溶剂合物、药学上可接受的盐或立体异构体：
。
55. 如前述实施方案47所述的组合物，其中，所述阳离子脂质包括以下化合物：YK-009、YK-401、YK-305、ALC0315、SM102、DLIN-MC3
。
56. 如实施方案47至55中任一项所述的组合物，其中，所述阳离子脂质与所述中性脂质的摩尔比为（1～10）：1。
57. 如实施方案47至55中任一项所述的组合物，其中，所述阳离子脂质与所述结构性脂质的摩尔比为（1～5）：1。
58. 如实施方案47至55中任一项所述的组合物，其中，所述阳离子脂质、所述中性脂质、所述结构性脂质以及所述聚合物共轭脂质的摩尔比为（25～75）：（5～25）：（15～65）：（0.5～10）。
59. 如实施方案58所述的组合物，其中，所述阳离子脂质、所述中性脂质、所述结构性脂质以及所述聚合物共轭脂质的摩尔比为（35~49）：（7.5~15）：（35~55）：（1~5），例如是49：10：39.5：1.5或45：10：43.5：1.5。
60. 如实施方案47至59中任一项所述的组合物，其中，所述中性脂质选自磷脂酰胆碱、磷脂酰乙醇胺、鞘磷脂、神经酰胺、甾醇及其衍生物中的一种或更多种。
61. 如实施方案47至60中任一项所述的组合物，其中，所述中性脂质选自以下中的一种或更多种：1,2-二亚油酰基-sn-甘油-3-磷酸胆碱(DLPC)、1,2-二肉豆蔻酰基-sn-甘油-磷酸胆碱(DMPC)、1,2-二油酰基-sn-甘油-3-磷酸胆碱(DOPC)、1,2-二棕榈酰基-sn-甘油-3-磷酸胆碱(DPPC)、1,2-二硬脂酰基-sn-甘油-3-磷酸胆碱(DSPC)、1,2-双十一烷酰基-sn-甘油-磷酸胆碱(DUPC)、1-棕榈酰基-2-油酰基-sn-甘油-3-磷酸胆碱(POPC)、1,2-二-O-十八碳烯基-sn-甘油-3-磷酸胆碱(18:0Diether PC)、1-油酰基-2-胆固醇基半琥珀酰基-sn-甘油-3-磷酸胆碱(OChemsPC)、1-十六烷基-sn-甘油-3-磷酸胆碱(C16 Lyso PC)、1,2-二亚麻酰基-sn-甘油-3-磷酸胆碱、1,2-二花生四烯酰基-sn-甘油-3-磷酸胆碱、1,2-双二十二碳六烯酰基-sn-甘油-3-磷酸胆碱、1,2-二油酰基-sn-甘油-3-磷酸乙醇胺(DOPE)、1,2-二植烷酰基-sn-甘油-3-磷酸乙醇胺(ME16.0PE)、1 ,2-二硬脂酰基-sn-甘油-3-磷酸乙醇胺、1,2-二亚油酰基-sn-甘油-3-磷酸乙醇胺、1,2-二亚麻酰基-sn-甘油-3-磷酸乙醇胺、1,2-二花生四烯酰基-sn-甘油-3-磷酸乙醇胺、1,2-双二十二碳六烯酰基-sn-甘油-3-磷酸乙醇胺、1,2-二油酰基-sn-甘油-3-磷酸-rac-(1-甘油)钠盐(DOPG)、二棕榈酰基磷脂酰甘油(DPPG)、棕榈酰基油酰基磷脂酰乙醇胺(POPE)、二硬脂酰基-磷脂酰-乙醇胺(DSPE)、二棕榈酰基磷脂酰乙醇胺(DPPE)、二肉豆蔻酰基磷酸乙醇胺(DMPE)、1-硬脂酰基-2-油酰基-硬脂酰乙醇胺(SOPE)、1-硬脂酰基-2-油酰基-磷脂酰胆碱(SOPC)、鞘磷脂、磷脂酰胆碱、磷脂酰乙醇胺、磷脂酰丝氨酸、磷脂酰肌醇、磷脂酸、棕榈酰基油酰基磷脂酰胆碱、溶血磷脂酰胆碱和溶血磷脂酰乙醇胺(LPE)。
62. 如实施方案47至61中任一项所述的组合物，其中所述中性脂质是DOPE和/或DSPC。
63. 如实施方案47至62中任一项所述的组合物，其中所述结构性脂质选自以下中的一种或更多种：胆固醇、非甾醇、谷固醇、麦角固醇、菜油甾醇、豆甾醇、芸苔甾醇、番茄碱、熊果酸、α-生育酚、皮质类固醇。
64. 如实施方案63所述的组合物，其中所述结构性脂质是胆固醇。
65. 如实施方案47至64中任一项所述的组合物，其中所述聚合物共轭脂质选自以下中的一种或更多种：PEG修饰的磷脂酰乙醇胺、PEG修饰的磷脂酸、PEG修饰的神经酰胺、PEG修饰的二烷基胺、PEG修饰的二酰基甘油、PEG修饰的二烷基甘油。
66. 如前述实施方案65所述的组合物，其中所述聚合物共轭脂质选自以下中的一种或更多种：二硬脂酰基磷脂酰乙醇胺聚乙二醇2000(DSPE-PEG2000)，二肉豆蔻酰甘油-3-甲氧基聚乙二醇2000(DMG-PEG2000)和甲氧基聚乙二醇双十四烷基乙酰胺(ALC-0159)。
67. 如实施方案44至66中任一项所述的组合物，其中所述RSV RNA的有效剂量为25 μg~200 μg；优选为50 μg~100 μg。
68. 如实施方案44至67中任一项所述的组合物，其中所述疫苗为注射剂型的形式。
69. 制备如实施方案44至68中任一项所述组合物的方法，包括：将所述RSV的RNA与所述可药用载剂混合，例如以将至少一部分所述RNA包裹在脂质纳米颗粒内部。
70. 实施方案1至41和44至68中任一项 所述的组合物在制备用于在对象中诱导针对RSV的保护性免疫应答特别是体液免疫应答的疫苗中的用途，所述保护性免疫应答例如包括产生中和抗体，所述对象例如为40岁以上或10岁以下，例如为50岁以上、55岁以上、60岁以上、65岁以上、70岁以上、75岁以上或80岁以上，或者为8岁以下、7岁以下、6岁以下、5岁以下、4岁以下、3岁以下或2岁以下。
71. 实施方案1至41和44至68中任一项所述的组合物在制备预防RSV感染的疫苗中的用途。
本发明的有益效果在于以下至少一种：
本申请在野生型RSV F蛋白的基础上，通过特定的变体形式（包括序列截短、位点突变和/或序列缺失），得到至少11条编码RSV F蛋白变体的核糖核酸，由此提供一种新型的预防RSV的mRNA疫苗，所述疫苗具有高稳定性，并且在接种后能显著提升体液免疫效果。所述效果包括以下至少一种：
提高RSV F突变体上融合前Φ表位与对应抗体的结合率；
提高RSV F突变体融合前构象在不同温度、渗透压和pH条件处理后的稳定性；
提高抗体与RSV F突变体融合前构象特异性抗原表位（Φ表位、Quaternary表位和/或V表位）的结合数量和结合能力；
提高经RSV F蛋白免疫后产生的中和抗体滴度；
显著降低体内的炎性反应以及病毒载量（包括肺部和鼻甲骨）；
能同时适用于多种RSV亚型。
具体来说：本发明的结果和技术效果如下：
(1)通过 Western Blot检测，结果显示以下50条RSV F突变体YK-RSV-001、YK-RSV-002、YK-RSV-003、YK-RSV-004、YK-RSV-005、YK-RSV-008、YK-RSV-009、YK-RSV-010、YK-RSV-011、YK-RSV-012、YK-RSV-013、YK-RSV-014、YK-RSV-015、YK-RSV-016、YK-RSV-017、YK-RSV-018、YK-RSV-019、YK-RSV-022、YK-RSV-029、YK-RSV-030、YK-RSV-031、YK-RSV-032、YK-RSV-033、YK-RSV-034、YK-RSV-035、YK-RSV-036、YK-RSV-037、YK-RSV-038、YK-RSV-039、YK-RSV-040、YK-RSV-041、YK-RSV-042、YK-RSV-043、YK-RSV-044、YK-RSV-045、YK-RSV-046、YK-RSV-048、YK-RSV-050、YK-RSV-051、YK-RSV-052、YK-RSV-053、YK-RSV-054、YK-RSV-055、YK-RSV-056、YK-RSV-057、YK-RSV-058、YK-RSV-059、YK-RSV-060、YK-RSV-061和YK-RSV-062均有明显的蛋白表达。
(2) 通过对RSV F突变体上的表位与相应抗体的结合率进行检测，筛选到以下42条RSV F突变体（包括YK-RSV-061、YK-RSV-003、YK-RSV-062、YK-RSV-054、YK-RSV-039、YK-RSV-044、YK-RSV-012、YK-RSV-015、YK-RSV-001、YK-RSV-036、YK-RSV-060、YK-RSV-005、YK-RSV-010、YK-RSV-017、YK-RSV-030、YK-RSV-038、YK-RSV-043、YK-RSV-055、YK-RSV-056、YK-RSV-057、YK-RSV-048、YK-RSV-052、YK-RSV-013、YK-RSV-002、YK-RSV-009、YK-RSV-050、YK-RSV-032、YK-RSV-019、YK-RSV-040、YK-RSV-046、YK-RSV-008、YK-RSV-059、YK-RSV-034、YK-RSV-004、YK-RSV-058、YK-RSV-016、YK-RSV-029、YK-RSV-035、YK-RSV-037、YK-RSV-011、YK-RSV-045、YK-RSV-051）上的Φ表位和II表位与对应抗体结合率约为80%左右或以上，结合率均良好。
(3)通过在不同温度、渗透压和pH条件下应激处理后进行稳定性测试，筛选出以下20条突变体（包括YK-RSV-061、YK-RSV-003、YK-RSV-062、YK-RSV-054、YK-RSV-039、YK-RSV-044、YK-RSV-012、YK-RSV-015、YK-RSV-001、YK-RSV-036、YK-RSV-060、YK-RSV-009、YK-RSV-010、YK-RSV-011、YK-RSV-030、YK-RSV-043、YK-RSV-048、YK-RSV-050、YK-RSV-055、YK-RSV-057）在4 ℃储藏一周后应激抗性参数均在0.44以上，可高达0.68；在50 ℃孵育60 min后应激抗性参数均在0.64以上；在高渗透压条件下处理60 min 后应激抗性参数均在0.61以上；在低渗透压条件下处理60 min 后应激抗性参数均为0.70以上；在pH=3.5和pH=10条件下处理60 min后应激抗性参数均为0.56以上。上述不同条件处理后的应激抗性参数均优于对照或与其效果相当。
(4)通过ELISA检测不同表位与对应抗体的结合水平，筛选出以下15个突变体（包括YK-RSV-061、YK-RSV-003、YK-RSV-062、YK-RSV-054、YK-RSV-039、YK-RSV-044、YK-RSV-012、YK-RSV-015、YK-RSV-001、YK-RSV-036、YK-RSV-060、YK-RSV-011、YK-RSV-030、YK-RSV-048、YK-RSV-050）上的Φ表位、Quaternary 表位、V表位三者与对应抗体均能良好结合，其表位结合数量较多，结合能力较强。
例如，YK-RSV-061、YK-RSV-003和YK-RSV-062上的Φ表位与RSV pre-F 抗体(3C12) 的结合水平是对照PC-RSV-064的1.83~2.00倍；Quaternary表位与RSV pre-F 抗体（7H11）的结合水平是对照PC-RSV-064的2.01~2.12倍。
YK-RSV-054上的Φ表位与RSV pre-F 抗体(3C12) 的结合水平是对照PC-RSV-064的2.52倍；Quaternary 表位与RSV pre-F 抗体(7H11) 的结合水平是对照PC-RSV-064的1.82倍；V表位与RSV F 抗体(7E11) 的结合水平是对照PC-RSV-064的3.30倍；II表位与RSVF 抗体(11A9) 的结合水平是对照PC-RSV-064的1.79倍；III表位与RSV F 抗体(4B9) 的结合水平是对照PC-RSV-064的2.27倍。
(5)采用BLI方法分析目的蛋白和不同抗体的亲和力，检测结果显示：13条突变体（包括YK-RSV-061、YK-RSV-003、YK-RSV-062、YK-RSV-054、YK-RSV-039、YK-RSV-044、YK-RSV-012、YK-RSV-015、YK-RSV-001、YK-RSV-036、YK-RSV-060、YK-RSV-011、YK-RSV-030）上的Φ表位和Quaternary表位，与对应抗体结合的亲和力最强。
突变体上的Φ表位与RSV pre-F 抗体（3C12）结合的亲和力常数KD为3.26E-12~7.79E-11 M，显著低于对照的KD值（KD约为E-10 M，相差1~2个数量级），表明抗原和抗体的亲和力较强。
突变体上的Quaternary表位与RSV pre-F 抗体（7H11）结合的亲和力常数KD为3.05E-12~6.13E-10 M，除YK-RSV-044、YK-RSV-060和YK-RSV-030与对照KD值相当外，其余突变体KD值均显著低于对照（相差1~2个数量级），表明抗原和抗体的亲和力较强。
(6)
小鼠：结合抗体
采用ELISA法检测小鼠免疫后第35天血清中融合前和融合后F蛋白特异性IgG 滴度，检测结果筛选出11个受试物（包括YK-RSV-061、YK-RSV-003、YK-RSV-062、YK-RSV-054、YK-RSV-039、YK-RSV-044、YK-RSV-012、YK-RSV-015、YK-RSV-001、YK-RSV-036、YK-RSV-060）的pre-F IgG抗体滴度是AbrysvoTM阳性对照的2.52 ~5.31倍，post-F IgG抗体滴度是AbrysvoTM阳性对照的1.13 ~5.21倍。
在所有检测的受试物中，pre-F/post-F比值均高于1，表明其融合前构象F蛋白比融合后构象F蛋白产生的IgG滴度要高。
小鼠：中和抗体
1）RSV A型病毒：采用基于斑点减少的微量中和试验法检测小鼠免疫后第35天血清中和抗体滴度筛选到11个受试物（包括YK-RSV-061、YK-RSV-003、YK-RSV-062、YK-RSV-054、YK-RSV-039、YK-RSV-044、YK-RSV-012、YK-RSV-015、YK-RSV-001、YK-RSV-036、YK-RSV-060）的中和抗体滴度IC50为AbrysvoTM阳性对照的3.72 ~12.67倍，IC90为AbrysvoTM阳性对照的2.34~14.41倍，均优于阳性对照。
2）RSV B型病毒：11个受试物（包括YK-RSV-061、YK-RSV-003、YK-RSV-062、YK-RSV-054、YK-RSV-039、YK-RSV-044、YK-RSV-012、YK-RSV-015、YK-RSV-001、YK-RSV-036、YK-RSV-060）的中和抗体滴度IC50为AbrysvoTM阳性对照的2.85 ~10.63倍，IC90为AbrysvoTM阳性对照的2.88 ~14.23倍，中和抗体滴度均显著高于阳性对照。
(7)
棉鼠：结合抗体
采用ELISA法检测棉鼠免疫后第42、48天血清中融合前和融合后F蛋白特异性IgG滴度，11个受试物（包括YK-RSV-061、YK-RSV-003、YK-RSV-062、YK-RSV-054、YK-RSV-039、YK-RSV-044、YK-RSV-012、YK-RSV-015、YK-RSV-001、YK-RSV-036、YK-RSV-060）：
第42天的pre-F IgG抗体滴度是AbrysvoTM阳性对照的3.05~13.10倍，post-F IgG抗体滴度是AbrysvoTM阳性对照的2.36 ~6.38倍，均显著高于阳性对照。所有受试物pre-F/post-F比值范围为1.39~3.95 ，表明融合前F蛋白产生的IgG抗体滴度显著高于融合后F蛋白。
第48天的pre-F IgG抗体滴度是AbrysvoTM阳性对照的4.44~12.35倍，post-F IgG抗体滴度是AbrysvoTM阳性对照的1.51~6.83倍，均显著高于阳性对照。所有受试物pre-F/post-F比值范围为1.78-4.29 倍，表明第48天免疫后，融合前F蛋白产生的IgG抗体滴度仍然显著高于融合后F蛋白。
棉鼠：中和抗体
通过检测棉鼠血清中针对RSV A2病毒所产生的中和抗体滴度，检测结果显示，11个受试物（包括YK-RSV-061、YK-RSV-003、YK-RSV-062、YK-RSV-054、YK-RSV-039、YK-RSV-044、YK-RSV-012、YK-RSV-015、YK-RSV-001、YK-RSV-036、YK-RSV-060）：
1）免疫后第42天，针对RSV A2病毒，中和抗体滴度IC50为AbrysvoTM阳性对照的2.10 ~14.30倍，IC90为AbrysvoTM阳性对照的2.26~22.33倍，均显著高于阳性对照。
针对RSV B病毒所产生的中和抗体滴度IC50为AbrysvoTM阳性对照的2.16~14.63倍，IC90为AbrysvoTM阳性对照的2.49~17.26倍，均显著高于阳性对照。
2）免疫后第48天，针对RSV A2病毒所产生的中和抗体滴度IC50为AbrysvoTM阳性对照的1.70 ~7.57倍，IC90为AbrysvoTM阳性对照的1.46~11.56倍，均高于阳性对照。
(8)通过棉鼠肺部病理切片结果显示：11个受试物（包括YK-RSV-061、YK-RSV-003、YK-RSV-062、YK-RSV-054、YK-RSV-039、YK-RSV-044、YK-RSV-012、YK-RSV-015、YK-RSV-001、YK-RSV-036、YK-RSV-060）：细支气管周浸润评分在0.33~0.83间，为轻度炎症浸润。所有受试物间质浸润评分均优于阳性对照AbrysvoTM，评分为0.67~1.17，为轻度炎症浸润。所有受试物整体炎性反应评分低，病理总评分在1.00~2.00间，均低于对照LNP。其中，对照和受试物血管周浸润和肺泡浸润两项指标评分均为0，该组织无可见病灶。
(9)棉鼠肺部和鼻甲骨病毒载量结果结果显示：11个受试物（包括YK-RSV-061、YK-RSV-003、YK-RSV-062、YK-RSV-054、YK-RSV-039、YK-RSV-044、YK-RSV-012、YK-RSV-015、YK-RSV-001、YK-RSV-036、YK-RSV-060）免疫后肺部病毒载量为1.61 ~2.08，低于阳性对照AbrysvoTM；鼻甲骨病毒载量为0.62~1.51，仅为阳性对照AbrysvoTM的0.19~0.45倍，病毒载量显著降低，表明受试物具有较好的抗病毒效果。
附图说明
图1：YK-RSV-001~YK- RSV-062的抗原表达情况；
图2（A）和（B）分别为第35天，小鼠血清RSV A2 pre-F结合抗体滴度；
图3（A）和（B）分别为第35天，小鼠血清RSV A2 post-F结合抗体滴度；
图4（A）和（B）分别为第35天，小鼠血清RSV A2中和抗体滴度IC50；
图5（A）和（B）分别为第35天，小鼠血清RSV A2中和抗体滴度IC90；
图6（A）和（B）分别为第35天，小鼠血清RSV B中和抗体滴度IC50；
图7（A）和（B）分别为第35天，小鼠血清RSV B中和抗体滴度IC90；
图8（A）和（B）分别为第42天，棉鼠血清RSV A2 pre-F结合抗体滴度；
图9（A）和（B）分别为第42天，棉鼠血清RSV A2 post-F结合抗体滴度；
图10（A）和（B）分别为第48天，棉鼠血清RSV A2 pre-F结合抗体滴度；
图11（A）和（B）分别为第48天，棉鼠血清RSV A2 post-F结合抗体滴度；
图12（A）和（B）分别为第42天，棉鼠血清RSV A2中和抗体滴度IC50；
图13（A）和（B）分别为第42天，棉鼠血清RSV A2中和抗体滴度IC90；
图14（A）和（B）分别为第42天，棉鼠血清RSV B中和抗体滴度IC50；
图15（A）和（B）分别为第42天，棉鼠血清RSV B中和抗体滴度IC90；
图16（A）和（B）分别为第48天，棉鼠血清RSV A2中和抗体滴度IC50；
图17（A）和（B）分别为第48天，棉鼠血清RSV A2中和抗体滴度IC90；
图18：显示采用本发明受试物处理后的棉鼠肺部病理切片结果。
具体实施方式
下面通过实施例来进一步说明本发明。应当理解为：本发明的实施例仅仅是用于说明本发明而给出，而不是对本发明的限制，在本发明技术方案的前提下对本发明的简单改进均属于本发明的保护范围。
如本文所用，氨基酸残基缩写如下：丙氨酸(Ala；A)、天冬酰胺(Asn；N)、天冬氨酸(Asp；D)、精氨酸(Arg；R)、半胱氨酸(Cys；C)、谷氨酸(Glu；E)、谷氨酰胺(Gln；Q)、甘氨酸(Gly；G)、组氨酸(His；H)、异亮氨酸(Ile；I)、亮氨酸(Leu；L)、赖氨酸(Lys；K)、甲硫氨酸(Met；M)、苯丙氨酸(Phe；F)、脯氨酸(Pro；P)、丝氨酸(Ser；S)、苏氨酸(Thr；T)、色氨酸(Trp；W)、酪氨酸(Tyr；Y)和缬氨酸(Val；V)。
本文中使用的以下术语具有下面所指出的含义。
疫苗
是指包含能够在个体中引发预防性或治疗性免疫应答的免疫原，其可以是药物组合物的形式。通常，疫苗引发针对病原体、例如病毒病原体的抗原的抗原特异性免疫应答。
核酸
核酸是包含核苷酸 (核苷酸单体)的聚合物。因此，核酸也称为多核苷酸。核酸可以是或可以包括例如脱氧核糖核酸 (DNA) 、核糖核酸 (RNA) 、苏糖核酸 (TNA) 、二醇核酸 (GNA) 、肽核酸 (PNA) 、锁核酸 (LNA，包括具有β-D-核糖构型的 LNA、具有α-L-核糖构型的α-LNA (LNA的非对映异构体)、具有2 ′-氨基官能化的 2 ′-氨基-LNA 和具有2 ′-氨基官能化的 2 ′-氨基-α- LNA) 、乙烯核酸 (ENA) 、环己 烯基核酸 (CeNA) 和/或其嵌合体和/或其组合。
信使RNA（mRNA）是编码 (至少一种) 蛋白质(一种天然存在的 、非天然存在的或修饰的 氨基酸聚合物) 并且可在体外、体内、原位或离体翻译以产生编码蛋白质的任何RNA。本领域技术人员将理解，除非另有说明，否则本申请中阐述的核酸序列可以在代表性DNA序列中列举“T”，但在所述序列代表RNA(例如，mRNA)的情况下，“T”将代替“U”。因此，本文中通过特定序列识别号公开和识别的任何DNA也公开了与DNA互补的相应R N A (例如，mRNA) 序列，其中 DNA序列的每个“T”被“U”取代。
开放阅读框 (ORF) 是一段连续的DNA或RNA，以起始密码子 (例如，甲硫氨酸(ATG或AUG)) 开始并以终止密码子(例如，TAA、TAG或TGA，或UAA、UAG或UGA) 结束。ORF通常编码蛋白质。应当理解，本文公开的序列还可包含额外的元件，例如，5 ′和3 ′UTR，但与ORF不同，这些元件不一定存在于本公开的RNA多核苷酸中。
本公开的组合物包含具有编码呼吸道合胞病毒抗原的开放阅读框 (ORF)的RNA。在一些实施方案中，所述RNA是信使RNA (mRNA) 。在一些实施方案中，所述RNA (例如，mRNA) 还包含5 ′UTR、3 ′UTR、多聚 (A) 尾和/或5′ 帽类似物（或称5′ 帽端帽子结构）。
还应理解，本公开的mRNA疫苗可包括任何5 ′非翻译区 (UTR) 和/或任何 3 ′UTR。示例性的UTR 序列在序列表中提供；然而，可以使用其他UTR序列或将其替换为本文所述的任何UTR序列。UTR也可以从本文提供的RNA多核苷酸中省略。
抗原
抗原是能够诱导免疫反应 (例如，导致免疫系统产生针对抗原的抗体)的蛋白质。在本文中，术语“抗原”的使用涵盖免疫原性蛋白质和免疫原性片段(其诱导 (或能够诱导)对(至少一种)呼吸道合胞病毒，例如，RSV A2（138251）) 的免疫反应的免疫原性片段，除非另有说明。应当理解，术语“蛋白质”涵盖肽并且术语“抗原”涵盖抗原片段。
序列表中提供了本公开的组合物的呼吸道合胞病毒抗原和编码所述呼吸道合胞病毒抗原的 RNA的示例性序列。
表位
又称抗原决定簇，是指抗原分子上能被特异性抗体识别的特定区域，在一个抗原分子上可能存在一个或更多个表位。抗原表位可被B细胞的表面受体（B-cell receptor，BCR）识别，引发后续的抗体合成和分泌并介导体液免疫反应。融合前pre-F构象有六个主要的抗原位点/表位（包括Φ，I，II，III，IV和V表位），通过对RSV F蛋白的晶体结构解析，发现AM14抗体特异性识别一个跨越两个原聚体的Quaternary表位，包括一个在融合前到融合后的F蛋白转变中经历广泛构象变化的区域。这些表位抗原性强，但相对不稳定；而融合后post-F构象只有四个抗原位点/表位（包括I，II，III和IV表位），虽较为稳定，但抗原性不强。相较于I、Ⅱ、Ⅲ和Ⅳ表位在融合前构象和融合后构象都存在，Φ和V表位只在pre-F构象中存在，且研究已证实它们是中和抗体敏感的位点，能诱导更高的中和抗体反应。本公开中抗体识别表位如下：
①识别Φ表位的RSV pre-F抗体（3C12）只与融合前构象的F蛋白发生特异性结合。
②RSV pre-F抗体（7H11）识别Quaternary表位（横跨IV和V两个表位），与融合前构象的F蛋白发生特异性结合。
③识别II表位的RSV F抗体（11A9）可以同时识别F蛋白的融合前和融合后构象。
④识别III表位的RSV F抗体（4B9），偏好识别融合前构象，同时与融合后构象具有较弱的结合活性。
⑤ RSV pre-F抗体 (7E11)识别V表位，与融合前构象的F蛋白发生特异性结合。
研究表明，能否与融合前抗原的Φ表位特异性结合以及结合的能力，与新疫苗预防RSV感染的效果息息相关。Φ和II表位分别占中和活性的~35%和<10%，RSV在人血清的中和活性主要来源于融合前特异性抗体，因此，使用保留Φ表位的融合前抗原，将有助于通过疫苗接种诱导或增强中和活性。
RSV F蛋白融合前和融合后构象抗原表位发生改变，其中，Φ表位仅保留在融合前构象，II表位在融合前和融合后构象均保留。抗原Φ表位特异性抗体有别于 RSV F蛋白上其他已知抗原表位的中和抗体，因为它只能特异性识别pre-F结构。研究表明能否与融合前抗原的Φ表位特异性结合以及结合的能力，与新疫苗预防RSV感染的效果的息息相关，因此将其作为主要指标进行考察。Φ表位位于pre-F三聚体结构的顶端，空间位阻小，有利于抗体结合。因此，抗体与Φ表位结合的能力越高，对RSV的预防效果越好。
采用单克隆抗体（mAbs）进行的表位结合分析，结果表明，与Φ表位特异性抗体结合的能力（例如，数量、结合率、结合力、结合程度等）与中和活性相关，而II表位的结合程度与中和相关性较差。并且，RSV在人血清的中和活性主要来源于pre-F特异性抗体，因此，接种疫苗是利用融合前构象的Φ表位进而提高中和活性。
RSV F蛋白融合前构象
在触发促融合事件前由RSV F蛋白采用的结构构象，所述促融合事件导致RSV F转变为融合后构象并且在加工后在分泌系统中变成成熟RSV F蛋白。在一些实施方案中，由突变体核酸编码的抗原是否稳定在融合前构象，可通过与特定表位结合来衡量。本发明的稳定的融合前RSV F突变体处于融合前构象，即它们包含 (展示) 至少一个表位，该至少一个表位对融合前构象F蛋白质是特异性的。对融合前构象F蛋白质具有特异性的表位是在融合后构象中不存在的表位。RSV F蛋白质的融合前构象可以含有与在天然RSV病毒粒子上表达的RSV F蛋白质上的那些相同的表位，并且因此可以提供用于引发保护性的中和抗体的优点。
在一些实施方案中，稳定的融合前RSV F突变体可以与识别Φ表位的RSV pre-F抗体（3C12）和Quaternary表位的RSV pre-F抗体（7H11）发生特异性结合。
RSV F蛋白融合后构象
由并非融合前构象的RSV F蛋白采用的结构构象，并且其中RSV F蛋白的N端 和C端在稳定的螺旋-螺旋中是接近的。RSV F蛋白的融合后构象已经在原子水平下描述(参见例如McLellan等,J.Virol.,85,7788,2011；Swanson等,Proc.Natl.Acad.Sci.U.S.A.,108,9619,2011；和以PDB登录号3RRR存放的结构坐标；所述文献各自以引用的方式并入本文中)。在融合后构象中，RSV F蛋白不能被某些抗体结合，例如识别Φ表位的抗体。
变体
在一些实施方案中，本公开的组合物包含编码呼吸道合胞病毒抗原变体的RNA。抗原变体或其他多肽变体是指其氨基酸序列与野生型、天然或参照序列不同的分子。与天然或参照序列相比，抗原/多肽变体可在氨基酸序列内的某些位置处具有替换、缺失和/或插入。通常，变体与野生型、天然或参照序列具有至少50％的同一性。在一些实施方案中 ，变体与野生型、天然或参照序列相比具有至少80％或至少90％的同一性，例如至少80%、81%、82%、83%、84%、85%、86%、87%、88%、89%、90%、91%、92%、93%、94%、95%、96%、97%、98%或至少99%或100%的同一性。在本文中，“突变体”与“变体”可互换使用。
突变
术语“突变”是指相较于野生型蛋白序列，氨基酸序列发生改变的现象。在本发明中，与野生型RSV F蛋白相比，抗原突变体具有一种或更多种碱基突变。突变之后与参照蛋白或多肽的氨基酸序列相比，蛋白或多肽的氨基酸序列中发生截短、氨基酸残基缺失或氨基酸残基替换。在本文中，在蛋白序列中的一个特定位置进行氨基酸替换使用注释“(野生型蛋白中的氨基酸残基)(氨基酸位置)(工程改造的蛋白中的氨基酸残基)”来表示。例如，Y44C是指参照蛋白的氨基酸序列的第44位的酪氨酸(Y)残基被半胱氨酸(C)残基替换(在参照蛋白的变体中)。在不同野生型序列间相同位置的氨基酸残基中存在变异的情况下，该注释中可省略位置编号之前的氨基酸代码，诸如“44C”。
序列截短
序列截短是指在野生型RSV F蛋白的基础上，C端氨基酸序列的一段连续部分被截掉。例如，在本发明中，序列截短为截掉RSV F蛋白C端550-574位氨基酸。
序列缺失
序列缺失是指在野生型RSV F蛋白的基础上，氨基酸位点发生部分碱基缺失。例如，在本发明中，所述序列缺失选自以下一种或更多种：第104-136位氨基酸缺失和第104-144位氨基酸缺失。
位点突变
位点突变是指在野生型RSV F蛋白的基础上，一个或更多个氨基酸位点发生改变，以使RSV F蛋白稳定在融合前构象。例如，在本发明中，所述位点突变选自以下：P102A、I379V和M447V、S46G、S215P、L373R、S213P和N216P、Q26C、N27C、T29C、E31C、F32C、Q34C、T36C、S41C、Y44C、Y53C、T54C、S55C、T100C、T103C、L138C、G139C、F140C、L141C、L142C、G145C、S146C、A147C、I148C、A149C、S150C、V152C、A153C、V154C、S155C、N183GC、S186C、L188C、S287C、I288C、S290C、I291C、I292C、V300C、L305C、Y306C、S319C、N325C、S330C、T337C、R339C、Q354C、T369C、M370C、N371C、S377C、N428C、Y458C、K461C、Q462C、K465C、L467C、Y468C、K470C、G471C；T54H、T58L、S190I、S190F、V207L、T219I、V296I；E92D、K465Q、D486S；V152I、C69Y、D73E、A74V、N88S。在上述可选的位点突变中，同一位置的氨基酸可发生其中一种类型的位点突变，例如，上述突变包括T54C或T54H，意味着54位T可突变位C或H，但不能同时发生。
缺少细胞质结构域
细胞质结构域由成熟RSV F蛋白的多肽链残基550-574构成。例如，在本发明中，缺少细胞质结构域意指抗原突变体C端氨基酸序列550-574被截掉。
“一个或更多个”/“选自”
在本文中，“一个或更多个”意指从所列对象或要素中选择出一个、两个或多个。类似地，“选自”意指从所列出的对象或要素清单中选择出其中一个、两个或多个，包括所列出的对象或要素的任意组合，如其中任意两个组合、任意三个组合，...,，任意多个组合，包括全部对象的组合。在此意义上，“更多个”可包括两个或三个或更多个。
由本公开的核酸编码的变体抗原/多肽可含有赋予多种期望性质中的任一者的氨基酸变化，例如，改善其稳定性或在动物体内增强免疫原性。变体抗原/多肽可使用常规诱变技术制备，并且适当时进行测定以确定它们是否具有期望性质。用以确定表达水平和免疫原性的测定是本领域众所周知的，并且示例性的此类测定在实施例部分中阐释。
在一些实施方案中，组合物包含RNA或RNA ORF，其包含本文提供的序列中的任一者的核苷酸序列 (参见序列表)，或包含与本文提供的序列中的任一者的核苷酸序列至少80%、至少85%、至少90%、至少95%、至少96%、至少97%、至少98%或至少99%或100%同一性的核苷酸序列。
术语“同一性”是指如通过比较序列确定的两种或更多种多肽 (例如抗原) 或多核苷酸 (核酸)的序列之间的关系。同一性也指如通过两个或更多个氨基酸残基或核酸残基串之间的匹配数确定的序列之间或之中的序列相关性程度。同一性度量由特定数学模型或计 算机程序 (例如，“算法”)处理的具有空位比对(如果有的话)的两个或更多个序列中的较小者间的同一性匹配百分比。相关抗原或核酸的同一性可容易地通过已 知方法计算。“同一性百分比 (％)”当应用于多肽或多核苷酸序列时，定义为在比对序列并引入空位(必要时)以实现最大同一性百分比之后，候选氨基酸或核酸序列中与第二序列的氨基酸序列或核酸序列中的残基(氨基酸残基或核酸残基)同一的残基的百分数。用于比对的方法和计算机程序是本领域中众所周知的。应理解，同一性取决于同一性百分比的计算，但由于计算中 引入的空位和罚分，同一性的值可能不同。通常，特定多核苷酸或多肽 (例如抗原)的变体与所述特定参 照多核苷酸或多肽具有如通过本文所述和本领域技术人员已知的序列比对程序和参数所确定的至少40%、45%、50%、55%、60%、65%、70%、75%、80%、85%、90%、91%、92%、93%、94%、95%、96%、97%、98%、99%但小于100%的序列同一性。用于比对的此类工具包括BLAST套件的那些工具 (Stephe n F .Altschul等人 (1997) ，“Gapped BLAST and PSI-BLAST：a new generation of protein database search programs”，Nucleic Acids Res.25：3389-3402) 。另一种常用局部比对技术是基于Smith-Waterman算法(Smith，T.F.和Waterman，M.S.(1981)“Identification of common molecular subsequences.” J .Mol.Biol .147 ：195-197) 。基于动态程序化的通用全局比对技术是Needleman-Wunsch算 法(Needleman ，S .B .和Wunsch ，C.D.(1970)“A general method applicable to thesearch for similarities in the amino acid sequences of two proteins.” J .Mol.Biol .48 ：443-453)。最近，已开发出一种快速最佳全局序列比对算法 (FOGSAA)，据称其比其他最佳全局比对方法(包括Need leman-Wunsch算法) 更快地产生核苷酸和蛋白质序列的全局比对。
因此，编码相对于参照序列、特别是本文公开的多肽 (例如抗原) 序列含有替换、插入和/或添加、缺失和共价修饰的肽或多肽的多核苷酸包括在本公开的范围内。在一些实施方案中，信号序列、终止序列、跨膜结构域、接头等 (或编码其) 的序列可用实现相同或相似功能的替代序列取代。在一些实施方案中，可例如通过引入更大的氨基酸填充蛋白质核心中的空腔以改善稳定性。在其他实施方案中，可用疏水性残基置换包埋的氢键网络以改进稳定性。本领域技术人员可容易地鉴定此类序列。
本公开提供的RSV F突变体包含F1多肽和F2多肽，其中F1多肽和F2多肽两者相对于相应天然F蛋白的氨基酸序列包括多个引入的氨基酸突变。RSV F突变体中此类氨基酸突变的引入赋予突变体有益特性，诸如增强的免疫原性，改善的稳定性，或突变体的特定期望物理形式或构象的形成或改善稳定性。
RSV F蛋白的突变体（变体）结构
人RSV的F糖蛋白首先从mRNA翻译为单一574个氨基酸的多肽前体（F0），其含有N-末端的信号肽序列。翻译后，在内质网中通过信号肽酶移除信号肽。F0在两个位点 (在氨基酸残基109/110 和136/137之间)处被转运高尔基氏体中的细胞蛋白酶（尤其弗林蛋白酶）切割，去除短的糖基化间插序列 (也称pep27区域，氨基酸残基110~136)，并产生称为F1（C-末端部分；氨基酸137~574）和F2（N-末端部分；氨基酸26~109）的两个结构域或亚基。F2连接至F1，F1-F2异二聚体在病毒粒子中组装为同源三聚体。
信号肽
“信号肽”是一种短的氨基酸序列 ( 例如长度为约18-25个氨基酸 )，通常是分泌途径上跨膜易位所需要的，控制真核生物和原核生物中大部分蛋白质进入分泌途径。信号肽常常但不普遍位于多肽的N端，并且常常在蛋白质穿过膜后被信号肽酶切去。
为了增强生成，F2 域之前可以有分泌信号肽，诸如天然 F蛋白信号肽或异源信号肽，用于在要表达重组 pre-F抗原的宿主细胞中增强生成和分泌。
F1多肽
术语“F1多肽”(F1)是指成熟RSV F蛋白的多肽链。天然F1包括RSV F0前体的近似残基137-574组成。如本文所用，该术语涵盖天然F1多肽和来自天然序列的包括修饰(例如，氨基酸替换、插入或缺失)的F1多肽两者，所述修饰例如被设计以稳定F突变体或增强F突变体的免疫原性的修饰。
F1在N-末端137~216包括疏水性融合肽（FP）和七肽重复区A（HRA），并且C-末端含有七肽重复区B (HRB)、跨膜（TM，氨基酸残基530~550）和胞质区（氨基酸残基551~574）。在RSV F蛋白突变体的结构中，包含整个F1域不是严格必要的。典型地，至少选择 F1域的亚序列 ( 或片段 )，并将其设计成维持包含 F 蛋白的免疫优势表位的稳定构象。F1中包含许多中和抗体识别的表位的亚序列，例如氨基酸残基262~275为帕利珠单抗识别表位亚序列；氨基酸残基423~436为Centocor的ch101F 单抗识别表位亚序列；氨基酸残基328~355包含T细胞表位。因此，F1域多肽包含RSV F蛋白多肽的至少约氨基酸262~436。
接头
可以通过删除或替代弗林蛋白酶识别位点的一个或更多个氨基酸来消除一个或两个弗林蛋白酶识别位点。凭借此设计，不从F2切割融合肽，这阻止从融合前构象异构体的球状头部释放和与邻近膜的可接近性。预测融合肽与膜界面之间的相互作用是融合前状态不稳定性的主要问题。融合过程期间，融合肽与靶膜之间的相互作用导致融合肽从球状头部结构内暴露，增强融合前状态的不稳定性，并折叠成融合后构象异构体。此构象变化实现膜融合过程。预测除去两个弗林蛋白酶切割位点之一或两者阻止膜与融合肽N端部分的可接近性，这稳定融合前状态。任选地，也可以除去或用例如接头肽替代居间pep27 肽。另外，或任选地，可以除去或替代接近融合肽的非弗林蛋白酶切割位点(例如第112位-第113位的金属蛋白酶位点)。
本申请采用的是用接头肽替代居间pep27 肽。对处于融合前状态的 RSV F 蛋白的结构模型的分析提示pep27在 F1和F2之间产生大的无约束环，此环并不促成融合前状态的稳定化，并且在弗林蛋白酶切割天然蛋白质后被除去。常用的蛋白接头包括柔性接头、刚性接头和可剪切接头，本申请使用的接头是柔性接头。
本申请中使用的接头可以在这种背景中使用而不破坏pre-F抗原的构象。
F2多肽
术语“F2多肽”(F2)是指成熟RSV F蛋白的多肽链。天然F2包括RSV F0前体的近似残基26-109。如本文所用，该术语涵盖天然F2多肽和来自天然序列的包括修饰(例如，氨基酸替换、插入或缺失)的F2多肽两者，所述修饰例如被设计以稳定F突变体或增强F突变体的免疫原性的修饰。
本领域技术人员会认可，包含整个F2域不是严格必要的。典型地，构象考虑在选择F2 域的亚序列( 或片段 )时是重要的。如此，F2 域通常包含F2 域中促进多肽装配和稳定性的部分。
稳定化元件
天然存在的真核mRNA分子除了例如5′-帽结构或3′-多聚(A)尾的其他结构特征之外，还可含有稳定化元件，包括但不限于在其5′端(5′UTR)和/或在其3′端(3′UTR)的非翻译区(UTR)。5′UTR和3′UTR二者都通常是从基因组DNA转录并且是成熟前mRNA的元件。通常在mRNA加工期间向转录的(成熟前)mRNA中添加成熟mRNA的特征性结构特征(例如5′-帽和3′-多聚(A)尾)。
在一些实施方案中，组合物包括具有编码至少一种具有至少一个修饰的抗原性多肽的开放阅读框、至少一个5′末端帽的RNA多核苷酸，并且配制在脂质纳米颗粒内。多核苷酸的5′-加帽可根据制造商的方案在体外转录反应期间使用以下化学RNA帽类似物同时完成，以产生5′-鸟苷帽结构。
3 ′-多聚 (A) 尾，即Ploy (A)尾，通常是添加至转录的mRNA的3 ′端的一段腺嘌呤核苷酸，位于含有多个连续单磷酸腺苷的3′UTR的下游、例如正下游(即，3′)的区。在一些情况下，其可包含约10~400个腺嘌呤核苷酸。在一些实施方案中，3 ′-多聚 (A) 尾的长度对于个别mRNA的稳定性可为必需的要素。在相关生物学环境中(例如，在细胞中，在体内)，多聚(A)尾用于保护mRNA免于例如在细胞质中的酶促降解，并帮助转录终止，和/或mRNA从细胞核输出和翻译。
非翻译区 (UTR)
本公开的mRNA可包含一个或更多个充当或用作非翻译区的区域或部分。当mRNA被设计为编码至少一种目标抗原时 ，核酸可包含这些非翻译区 (UTR) 中的一者或多者。核酸的野生型非翻译区被转录，但未被翻译。在mRNA中，5 ′UTR在转录起始位点开始，并继续至起始密码子，但不包括起始密码子；而3 ′UTR在终止密码子之后立即开始，并继续至转录终止信号。越来越多的证据表明UTR在核酸分子的稳定性和翻译方面所起的调控作用。UTR的调控特征可并入本公开的多核苷酸中，以尤其增强分子的稳定性。还可并入特定特征以确保在转录物被错误导向不期望器官部位的情形下转录物的受控下调。
5 ′UTR是指不编码多肽的mRNA在起始密码子 (核糖体翻译的mRNA转录物的第一个密码子) 正上游 (5 ′)的区。5 ′UTR不编码蛋白质(是非编码的) 。天然5 ′UTR具有在翻译起始中起作用的特征。它们带有印记如Kozak 序列，通常已知所述Kozak 序列参与核糖体起始许 多基因翻译的过程。Kozak序列具有共有CCR (A/G) CCAUGG，其中R是起始密码子(AUG) 上游三个碱基处的嘌呤 (腺嘌呤或鸟嘌呤)，起始密码子 (AUG)后接另一个‘G’。还已知5 ′UTR形成参与延伸因子结合的二级结构。
3 ′UTR是指不编码多肽的mRNA的在终止密码子 (mRNA转录物的发出翻译终止信号的 密码子) 正下游 (3 ′) 的区。3 ′UTR不编码蛋白质(是非编码的)。已知天然或野生型3 ′UTR具有嵌入其中的腺苷和尿苷的段。
本领域的普通技术人员将理解，异源或合成的5 ′UTR可与任何期望的3′UTR序列一起使用。例如，异源5 ′UTR可与合成3 ′UTR或异源3 ′UTR一起使用。
RNA的体外转录
编码本文所述的多核苷酸的cDNA可使用体外转录(IVT)系统转录。RNA的体外转录是本领域中已知的，并且阐述于国际公开WO/2014/152027中，所述公开通过引用整体并入本文。
在一些实施方案中，所述RNA转录物是使用线性化DNA模板在体外转录反应中产生，以产生RNA转录物。
在一些实施方案中，体外转录模板编码5′非翻译(UTR)区，含有开放阅读框，并编码3′UTR和多聚(A)尾。体外转录模板的特定核酸序列组成和长度将取决于模板编码的mRNA。
体外转录系统通常包含转录缓冲液、核苷酸三磷酸(NTP)、RNA酶抑制剂和聚合酶。
所述NTP可在内部制造，也可来自供应商。所述NTP可选自但不限于本文所述的那些NTP，包括天然和非天然(经修饰的)NTP。
在一些实施方案中，RNA转录物通过酶促加帽来加帽。在一些实施方案中，RNA包含5′末端帽。
脂质纳米颗粒 (LNP)
在一些实施方案中，本公开的RNA (例如，mRNA) 配制在脂质纳米颗粒 (LNP) 中。脂质纳米颗粒通常包含可电离阳离子脂质、非阳离子脂质、固醇和PEG脂质组分以及目标核酸物。本公开的脂质纳米颗粒可使用本领域中通常已知的组分、组合物和方法产生。
RSV F蛋白突变体稳定性
在一些实施方案中，本公开中核酸编码的突变体抗原具有比野生型更优越的性能，如增强的融合前构象的稳定性。在本实施例中已具体阐述用以确定融合前构象稳定性的测定方法。
在一些实施方案中，由突变体核酸编码的抗原的稳定性可通过测定热稳定性和低温稳定性来衡量。“热稳定性”，在本实施例中指的是经受增加的温度（即，50 ℃）60 min之后 ，突变体仍显示至少一个融合前的特异性表位，例如，本申请中测定是与Φ表位的结合。“低温稳定性”在本实施例中指的是4 ℃低温储藏一周后，突变体仍显示至少一个融合前的特异性表位，例如，本申请中测定是与Φ表位的结合。与不具有前面所述一种或多种突变的RSV F多肽相比，根据本发明的一些融合前RSV F突变体在低温储藏或者受热时具有增加的稳定性。
在一些实施方案中，由突变体核酸编码的抗原的稳定性可通过测定在低渗透压和高渗透压条件下稳定性来衡量。
“低渗透压稳定性”，在本实施例中指的是在10 mM NaCl低渗透压条件下孵育60min后，突变体仍显示至少一个融合前的特异性表位，例如，本申请中测定是与Φ表位的结合。与不具有前面所述一种或多种突变的RSV F多肽相比，根据本发明的一些融合前RSV F突变体在低渗透压条件下具有增加的稳定性。
“高渗透压稳定性”，在本实施例中指的是在3.0 M MgCl2高渗透压条件下孵育60min后，突变体仍显示至少一个融合前的特异性表位，例如，本申请中测定是与Φ表位的结合。与不具有前面所述一种或多种突变的RSV F多肽相比，根据本发明的一些融合前RSV F突变体在高渗透压条件下也具有增加的稳定性。
在一些实施方案中，由突变体核酸编码的抗原的稳定性可通过测定在酸和碱条件下稳定性来衡量。
“酸和碱稳定性”，在本实施例中指的是RSV F突变体在pH 3.5和pH 10条件下室温孵育60 min，随后中和至pH 7.4后，突变体仍显示至少一个融合前的特异性表位，例如，本申请中测定是与Φ表位的结合。与不具有前面所述一种或多种突变的RSV F多肽相比，根据本发明的一些融合前RSV F突变体在酸和碱条件下具有增加的稳定性。
生物膜干涉技术
生物膜干涉技术（Bio-Layer Interferometry，简称BLI）是一种无标记的、实时监测的光学检测技术，主要用于生物分子间相互作用的全方位定量分析以及蛋白浓度测定。BLI可实时监控整个分子间的结合过程，并计算出分子之间的亲和力常数(KD)、结合速率常数(Ka)、解离速率常数(Kd)等重要数据。
在一些实施方案中，RSV F蛋白突变体和不同表位抗体的亲和力通过BLI测定。本实施例中，主要是检测与RSVpre-F 抗体（3C12）、RSV pre-F 抗体（7H11）亲和力。
疫苗免疫原性
术语“免疫原性”是指物质在佐剂存在或不存在的情况下，在动物中引起、引发、刺激或诱导针对特定抗原的免疫应答的能力。在本发明的意义上，免疫原是所提供的人工核酸、优选RNA的翻译产物 ，其包含编码至少一种衍生自本文所定义的 RSV的抗原肽、蛋白的至少一个编码序列。
术语“中和抗体”是指在病原体感染过程中，可以阻止病原体与宿主细胞表面受体相互结合，从而使病原体不能与靶细胞黏附并侵入靶细胞中复制和繁殖的抗体。通常用“中和抗体”水平的高低直观反映疫苗的效果。
在一些实施方案中，在鼠类模型中测量免疫组合物 (例如RNA疫苗) 有效的能力。例如，可将免疫组合物施用给鼠类模型，并且测定所述鼠类模型的中和抗体滴度的诱导。在一些实施方案中，抗原特异性免疫反应测量为小鼠或棉鼠血清中和抗体滴度的几何平均滴度 (GMT)。几何平均滴度 (GMT) 是通过将所有值相乘并且取所述数的n次方根来计算的一组受试者的平均抗体滴度，其中n是具有可用数据的受试者的数目。
病毒攻击研究还可用于评估本公开的疫苗的功效。例如，可将免疫组合物施用给鼠类模型，用病毒攻击鼠类模型，并测定鼠类模型的存活和/或免疫反应 (例如中和抗体反应) 。
杂环“杂环”和“杂环基”在本文中可交换使用，都是指非芳香性杂环基，其中一个或多个成环的原子是杂原子，如氧、氮、硫原子等，包括单环、稠环、桥环和螺环。优选具有5至7元单环或7至10元双-或三环，其可以包含1，2或3个选自氮、氧和/或硫中的原子。“杂环基”的实例包括但不限于吗啉基，氧杂环丁烷基，硫代吗啉基，四氢吡喃基，吗啉基，哌啶基，2-氧代-哌啶基，吡咯烷基，2-氧代-吡咯烷基，哌嗪-2-酮和哌嗪基。杂环基可以是取代或未取代的。
1.1 实施例1 ：RSV F抗原突变体设计
本发明主要参考RSV A2（138251）蛋白序列，在此基础上进行P102A、I379V和M447V突变（52条候选突变体的抗原序列（序号1-52）以及6条对照序列（序号53-58）均含有上述3个突变，其他突变形式见下表）。
采用多种突变组合的形式，共设计了52条候选突变体的抗原序列（序号1-52）以及6条对照序列（序号53-58），1条野生序列（序号59），1条阳性对照（序号60），具体突变体的突变组合如下表所示。
阳性对照来源于辉瑞已上市的疫苗AbrysvoTM (NDC 0069-0344-05)，与本发明设计的mRNA疫苗不同的是，其为蛋白质疫苗。
对照序列设计思路：在本申请设计的突变体基础上，为探究不同位点突变的作用，设计了不同对照序列。例如，
①为探究位点突变中组2和3中突变的影响，在YK-RSV-003突变组合的基础上，设计了PC-RSV-063。
②为探究位点突变中组1中突变的影响，在YK-RSV-061突变组合的基础上，改变组1中突变类型，设计了PC-RSV-067和PC-RSV-068；
③为探究位点突变中组2和组3中突变的影响，在YK-RSV-061突变组合的基础上，设计了PC-RSV-064、PC-RSV-065、PC-RSV-066。
1、参照“M Gordon Joyce et al., Iterative structure-based improvementof a fusion-glycoprotein vaccine against RSV, Nature Structural&MolecularBiology volume 23, 811–820 (2016),doi:10.1038/nsmb.3267”中“Design cycle 4中，RSV F variant：sc9-10 DS-Cav1 A149C Y458C S46G K465Q S215P E92D；Mutations：A149C, S155C, S190F, V207L, S290C, L373R, Y458C, S46G, K465Q, S215P, E92D；F1-F2 Linker residues：103-145；Linker sequence：GS；End residue：513”，设计突变体PC-RSV-063。
2、参照专利申请公开“WO2023/166079 A1”中“序列编号6”设计突变体PC-RSV-064。
。
1.2 实施例2：RSV F抗原mRNA疫苗制备
通过设计抗原序列后，将其合成到载体pVaX1上，该载体具有优化后5'-UTR、3'-UTR和polyA尾，所有质粒均由安升达生物公司负责合成。合成质粒进行线性化酶切，通过体外转录制备mRNA原液，并进行LNP包裹，获得mRNA制剂样品。
其中，以pVaX1为基本骨架转录后的mRNA，用于后续Western Blot、流式细胞术分析抗原表位结合、ELISA检测抗原表位结合、BLI检测抗原与抗体亲和力。在载体骨架上添加HIS- 标签和T4 fibritin折叠子，用于分泌蛋白形成三聚体的稳定性检测。
mRNA样品的具体制备过程如下所述。
1.2.1mRNA原液制备
1）实验材料
NEB®Golden Gate组装试剂盒(BsaI-HFv2)（NEB，Cat.No.: R3733）；
DNA产物纯化试剂盒（购自天根生化科技(北京)有限公司（简称天根）,Cat. No.:DP205）；
ATP（购自上海兆维生物技术有限公司（简称兆维）,Cat. No.: R1-051）;
CTP（兆维，Cat. No.: R3-056）;
GTP（兆维，Cat. No.: R2-057）;
N1-Me-pUTP（兆维，Cat. No.: R5-064）;
Cap1-GAG m7G(5’)ppp(5’)(2’OMeA)pG（兆维，Cat. No.: ON-134）;
T7 RNA 聚合酶Polymerase（兆维，Cat. No.: ON-004）;
RNA酶抑制剂（RNase Inhibitor）（兆维，Cat. No.: ON-039）;
焦磷酸酶Pyrophosphatase（兆维，Cat. No.: ON-025）;
10× IVT 反应缓冲液（兆维，Cat. No.: ON-062）；
DNA酶I（DNase I）（兆维，Cat. No.: ON-109）。
2）实验流程
① 质粒线性化酶切
采用BsaI-HFv2内切酶线性化处理质粒DNA，酶切系统中包括插入目标基因的质粒DNA、10 × rCutSmart 缓冲液、BsaI-HFv2和 无菌无酶水（RNase-free ddH2O）。酶切反应温度37 °C，酶切时间15-30 min，酶切体系见下表。
酶切反应完成后，使用DNA产物纯化试剂盒回收线性化产物，使用超微量紫外分光光度计（Denovix）测定产物浓度，通过琼脂糖凝胶检测线性化质粒模板长度及状态。
② 共转录加帽
以上述步骤中制备的线性化质粒为模板，NTP溶液（NTPs）、cap1帽类似物为起始物料，通过T7 RNA聚合酶转录合成mRNA。上述cap1帽类似物为Cap1-GAG，具有m7G (5') ppp(5') (2'-OMeA) pG结构，其分子式为C32H43N15O24P4。
具体反应体系见下表，将配制好的反应体系置于37 °C恒温箱振荡培养反应3 h。
在上述反应完成的20 μl共转录加帽反应体系中加入1 μl DNase Ⅰ，混匀后置于37 °C 消化30 min，得到共转录加帽产物。
③ LiCl沉淀法纯化
将上述得到的共转录加帽产物用氯化锂沉淀法纯化，方法如下：
加入LiCl：向共转录加帽产物中加入LiCl，终浓度为2.8 M，低温沉淀2 h。
沉淀：12000 rmp高速离心15 min，保留沉淀。
洗涤：用75%乙醇洗涤2次，用无菌无酶水溶解得到mRNA原液。
检测：纯化后的转录产物通过超微量紫外分光光度计（Denovix）测定浓度，通过毛细管电泳检测完整性。
1.2.2 mRNA-LNP（mRNA疫苗）的制备
分别准确称量阳离子脂质、DSPC、胆固醇、DMG-PEG2000，加无水乙醇溶解，按照摩尔比（控制阳离子脂质、中性脂质、结构性脂质以及聚合物共轭脂质的摩尔比为49：10：39.5：1.5）配制载体混合溶液，作为有机相备用。
用柠檬酸缓冲液溶解mRNA，并稀释配制成溶液，作为水相备用。用BDTM注射器分别抽取有机相和水相，左边泵放置有机相，右边泵放置水相，在微流控设备中制备LNP中间体溶液。
上述LNP中间体溶液加入PBS溶液稀释，在超滤设备上超滤浓缩，浓缩至一定体积后，再加入PBS溶液稀释，并在超滤设备上浓缩，最终浓缩体积小于5 ml时停止超滤。
1.3 实施例3： Western Blot检测RSV F抗原突变体表达
为了验证设计的抗原mRNA是否能在细胞中表达，将mRNA转染细胞，使用WesternBlot检测抗原mRNA在细胞中的表达情况。
1）实验材料
293T细胞（购自ATCC细胞库）；
一抗：HRSV-F（购自京天成生物技术(北京)有限公司，以下简称京天成，Cat. No.:11049-R302）；
二抗：山羊抗小鼠IgG（H+L）二抗（Goat Anti-Mouse IgG（H+L）SecondaryAntibody）, HRP（购自上海碧云天生物技术有限公司，以下简称碧云天，Cat. No.:A0286）；
实验组：实施例2制备的系列mRNA疫苗转染细胞后裂解处理所得的蛋白样品混合液；
内参蛋白：甘油醛-3-磷酸脱氢酶GAPDH；
2）实验流程
细胞培养和转染：将293T细胞以1.3×105 /孔接种到24孔板中。第二天将mRNA-LNP样品（包含mRNA 300 ng）直接加入到细胞中，混合均匀。
蛋白样品准备：① 细胞经转染16小时后从培养箱中取出，移液器反复吹吸致使细胞全部脱离皿底，把细胞转移至1.5 ml离心管中，25 °C，1500 rpm离心3 min。② 弃上清液，加入PBS 1 ml吹吸重悬细胞；离心，1500 rpm离心3 min。③ 重复上一步骤2次。④每管细胞加入50 μl RIPA裂解液（RIPA裂解液使用前加入0.5 μl 100×蛋白抑制剂），冰上放置30 min，期间每5 min涡旋样品30 s。⑤预冷离心机，细胞充分裂解后，样品于 4 ℃，12000rpm离心10 min，吸取上清液转移至新的1.5 ml离心管中，获得待测蛋白样品。
显影以及分析：使用BCA定量试剂盒检测蛋白样品浓度。吸取样品进行点样，marker点样4 μl，200V电泳30 min。转膜使用干转膜仪，将胶取出并制作转膜“三明治”，盖上负极板，电压21V，23V，25V转膜分别1，4，2 min；然后室温封闭1 h。一抗孵育：室温孵育1h。洗膜：洗液使用1×TBST缓冲溶液，5 min/次，3次。二抗孵育：室温孵育1 h。洗膜：使用1×TBST缓冲溶液清洗，5 min/次，3次。显色：显影液和定影液各1 ml进行1:1混合，滴加到膜上进行显色，拍照。
1.4 实施例4：流式细胞术检测RSV F抗原突变体Φ和II表位结合
为探究RSV F抗原突变体是否具有融合前表位，本实施例中使用RSV pre-F 抗体（3C12）（特异性结合RSV pre-F Φ表位）和RSV F 抗体（11A9）（结合pre-F和post-F II表位）进行流式细胞术检测，预期处于pre-F构象的RSV F蛋白突变体结合所测试的抗体。
1）实验材料
293T细胞（购自ATCC细胞库）；RSV pre-F 抗体（3C12）, Φ表位（Epitope Φ）（近岸蛋白，Cat. No.:DA101）；RSV F 抗体（11A9）, II表位（Epitope II）（近岸蛋白，Cat.No.:DA091）；
实验组：实施例3有表达的抗原对应的mRNA疫苗；
2）实验流程
① 细胞转染：将293T细胞以1.3×105 /孔接种到24孔板中。第二天将mRNA-LNP样品（包含mRNA 300 ng）直接加入到细胞中，混合均匀。
② 细胞收集：细胞经转染16 h后从培养箱中取出，使用移液器吸弃培养基，用移液器吸取500 μl的0.1%BSA溶液清洗孔板中残留的培养基，注意别把细胞吹起，使用移液器吸弃0.1%BSA溶液。向每孔添加500 μl的0.1%BSA溶液，吹打细胞并转移至1.5 ml离心管中。
③ 离心：避光，400 g 4 °C离心5 min收获细胞，弃上清。
④ 染色：对照和待检样品中分别加入50.6 μl RSV荧光抗体稀释液重悬细胞，样品在4 °C避光孵育2 h。
⑤ 清洗：孵育完成后，每管样品添加500 μl的0.1%BSA溶液，避光，400g 4°C 离心5 min收获细胞，弃上清。此操作重复三次。
⑥ 重悬细胞：每个样本加入200 μl 0.1%BSA溶液，用移液器小心吹打细胞，制成细胞悬液。
⑦ 流式上机检测：使用流式细胞仪测量RSV F突变体与抗体的结合动力学，每次测量检测1×104个细胞。
1.5 实施例5：ELISA检测RSV F抗原突变体稳定性
为探究RSV F抗原突变体在不同pH、温度、渗透压等条件下的稳定性，本实施例对突变体进行不同处理条件下的应激测试。
1）实验材料
293T细胞（购自ATCC细胞库）；
一抗：RSV pre-F 抗体 (3C12)，Φ表位（购自苏州近岸蛋白质科技股份有限公司(简称近岸)，Cat. No.: DA101）；
标准品：RSV pre-F三聚体蛋白（RSV pre-F Trimer Protein）（近岸，Cat. No.:DRA230）；
二抗：过氧化物酶标记的山羊抗小鼠IgG(H+L)（Peroxidase AffiniPure GoatAnti-Human IgG（H+L））（购自翌圣生物科技（上海）股份有限公司（简称翌圣），Cat. No.:N/A）；
实验组：实施例4筛选后的mRNA疫苗；
2）实验流程：
①细胞转染和收集：转染步骤同实施例3，收集细胞上清。
②不同 pH条件：用10% NaOH和1 M HCl溶液将RSV F蛋白溶液分别调节至pH 3.5和pH 10，并在室温下孵育60 min，随后中和至pH 7.4。
③ 高温处理：RSV F蛋白溶液在50°C孵育60 min。
④ 低温处理：RSV F蛋白溶液在4°C低温储藏一周。
⑤ 低渗透压处理：细胞上清液中含有110 mM NaCl，用2.5 mM Tris缓冲液（pH7.5）稀释至10 mM NaCl，并在室温下孵育60 min。
⑥ 高渗透压处理：细胞上清液用4.5 M MgCl2调节至3.0 M MgCl2，并在室温下孵育60 min。
⑦ ELISA检测抗原表达：
包被：将包被工作液加入96孔酶标板中，2 °C ~8 °C放置16 h~20 h。
洗板：每孔加入磷酸缓冲盐溶液PBST，使用洗板机洗板，洗板5次，在吸水纸上拍干。
封闭：加入封闭液后置于酶标恒温振荡器上，37 °C，400 rpm，孵育1.5 h。
洗板：每孔加入PBST洗液，使用洗板机洗板，洗板5次，在吸水纸上拍干。
一抗孵育：每孔加入一抗稀释液，用封板膜封板后，37 °C 400 rpm孵育1.5 h。
洗板：每孔加入PBST洗液，使用洗板机洗板，洗板5次，在吸水纸上拍干。
二抗孵育：每孔加入二抗稀释液，用封板膜封板后，37 °C 400 rpm孵育45 min。
洗板：每孔加入PBST洗液，使用洗板机洗板，洗板5次，在吸水纸上拍干。
显色：加入显色液，封板膜密封后，置于酶标恒温振荡器上，37 °C，400 rpm，孵育25 min。
终止反应：显色结束后，向酶标板中加入50 μl/孔终止液终止反应。
读板：使用多功能酶标仪，设置450 nm及630 nm的双波长，5 min内读取吸光度值（OD值）。
1.6 实施例6：ELISA检测RSV F抗原突变体的不同表位结合
为探究RSV F抗原突变体和识别不同表位抗体的结合，本实施例采用ELISA方法进行结合量测定。
1）实验材料
293T细胞（购自ATCC细胞库）；
一抗：RSV pre-F 抗体（3C12），Φ表位（Epitope Φ）（近岸，Cat. No.: DA101）；
RSV pre-F 抗体（7H11）, Quaternary表位（Epitope Quaternary）（近岸，Cat.No.:DA109）；
RSV F 抗体（11A9）, II表位（Epitope II）（近岸，Cat. No.:DA091）；
RSV F 抗体（4B9）, III表位（Epitope III）（近岸，Cat. No.:DA110）；
RSV pre-F 抗体 (7E11), V表位（Epitope V）(Cat. No.:DA119)；
标准品：RSV-pre-F三聚体蛋白（RSV Prefusion F-Trimer Protein）（近岸，Cat.No.: DRA230）；
二抗：过氧化物酶标记的山羊抗小鼠IgG(H+L)（Peroxidase AffiniPure GoatAnti-Human IgG（H+L））（翌圣，Cat. No.: N/A）；
实验组：实施例5筛选后的mRNA疫苗；
2）实验流程
细胞培养和转染、蛋白样品制备：实验过程同实施例3。
ELISA检测抗原表达：实验过程同实施例5。
1.7 实施例7：BLI检测RSV F抗原突变体与不同抗体亲和力
为探究RSV F抗原突变体和特异性识别融合前构象表位的抗体的亲和力，本实施例采用生物膜干涉技术（Bio-Layer Interferometry，BLI）方法进行亲和力测定。
1）实验材料
293T细胞（购自ATCC细胞库）；
RSV pre-F抗体（3C12），Φ表位（近岸，Cat. No.: DA101）；
RSV pre-F抗体（7H11）, Quaternary表位（近岸，Cat. No.:DA109）；
实验组：实施例6筛选后的mRNA疫苗；
2）实验流程：
蛋白样品制备：实验过程同实施例3。
使用1×PBST溶液分别将抗体稀释到10 µg/ml。
在1×PBST溶液中用ProA探针分别捕获抗体RSV pre-F 抗体（3C12）、RSV pre-F抗体（7H11），捕获水平限制为4.0 nm；随后依次与稀释后的目标蛋白进行反应，充分反应后的固相结合物在1×PBST缓冲液中进行解离分析。
使用蛋白相互作用仪进行检测，以Data Analysis12.0软件对结果分析，获得结合速率、解离速率及亲和力常数。
1.8 实施例8：RSV F抗原突变体在小鼠体内免疫原性研究
为探究RSV F抗原在小鼠体内产生的抗体滴度，本实施例对小鼠进行体内免疫。
1.8.1 Balb/c小鼠免疫
1）实验材料
动物：Balb/c小鼠，雌性，6~8周；
阴性对照：LNP样品；
阳性对照：AbrysvoTM；
受试物： YK-RSV-001、YK-RSV-011、YK-RSV-030、YK-RSV-036、YK-RSV-044、YK-RSV-060、YK-RSV-062、YK-RSV-061、YK-RSV-003、YK-RSV-012、YK-RSV-015、YK-RSV-039、YK-RSV-054；
2）小鼠免疫接种方案
注：给药体积根据给药剂量实际浓度计算
3）样品采集和预处理
每只动物眼眶静脉丛取血量约为0.2 ml，分离血清（4 ℃条件下4000 rpm/min离心10 min），放入4 °C冰箱保存待处理。
4）健康检测
每天1次，包括但不限于死亡、发病、呼吸、分泌物、粪便以及饮食和饮水情况。
5）人道终点
根据IACUC方案规定，实验期间任何小鼠体重下降超过20%（感染前以第0天体重为基准体重，感染后以接毒当天体重为基准体重），或/以及表现出濒死症状，将被执行安乐死，并在结果中记为死亡动物。
1.8.2 小鼠血清RSV中和抗体滴度检测
1）检测目的
使用基于斑点减少的微量中和试验法，检测血清中抗呼吸道合胞病毒RSV A2和RSV B18357中和抗体滴度。
2）关键试剂
一抗：帕利珠单抗Research Grade Palivizumab（购自武汉科斯坦生物科技有限公司，以下简称武汉科斯坦，Cat. No.: CSD00024）；
二抗：兔抗人IgG H&L(HRP)（Abcam，Cat. No.: ab6759）；
3）数据计算公式：
① 样本抑制率：由Excel计算所得（单孔计算），样本抑制率=（1-（样本斑点数/病毒对照斑点数））×100%。
② 将样本稀释倍数为X轴，抑制率为Y轴，输入GraphPad软件，使用四参数拟合，计算样本的IC50值和线性相关系数R2，IC50值即为样本的中和抗体滴度。滴度保留整数，线性相关系数R2保留至小数点后两位。
③ 平均值： ，Xi表示第几次测定值，n表示测定次数；由Excel计算所得，保留至小数点后第二位。注：若计算结果为滴度值，保留整数。
4）实验流程
通过对待测血清样本进行梯度稀释后，加入一定量的RSV病毒，中和反应后，将混合物加入到细胞板中进行培养22~26 h，根据斑点的形成情况最终计算得到血清样本中和抗体效价水平。操作流程如下：
细胞准备和种板：HEp-2细胞购自上海誉驰生物。实验前进行复苏和培养，检测时使用的代次为复苏后3~20代。提前将细胞消化接种至96孔板中，2.5×105 cells/ml，0.1ml/孔，置于37 °C、5% CO2培养箱培养17 h~23 h。确认细胞无异常，取血清样本，按照梯度进行稀释。
设置对照：在96孔板（中和板）中设置对照，细胞对照（CC）和病毒对照（VC）分别加入稀释液，分别设置复孔。
病毒加入：取用稀释液稀释后的病毒，加入96孔板的样本孔及VC孔中，轻拍96孔板使样本和病毒混匀后，放入37 °C、5% CO2培养箱孵育进行中和反应。
细胞准备、侵染和培养：取提前接种细胞的96孔板，吸弃原培养基，吸取中和板混合液加入至铺有细胞的96孔板中，放入37 °C、5% CO2培养箱培养。
固定和染色：培养后，吸弃原培养液，每孔加入一定体积的固定液。固定后弃固定液，1×PBS重复洗涤2次。加入封闭液封闭后，弃封闭液，1×PBS重复洗涤2次；加入一抗工作液孵育后，弃抗体，1×PBS重复洗涤2次；加入HRP二抗工作液孵育后，弃抗体，1×PBS重复洗涤2次；加入显色液，室温孵育5~20 min；弃显色液，拍干，酶联免疫斑点分析仪计数斑点。
结果计算: 中和抗体滴度：计算样本各梯度的抑制率，将样本稀释倍数-抑制率输入GraphPad软件进行拟合，计算样本的IC50和IC90值，IC50和IC90值即为样本的中和抗体滴度。
1.8.3 小鼠血清RSV结合抗体滴度检测
1）检测目的
采用经验证合格的自建间接ELISA法对RSV mRNA疫苗免疫原性试验中的血清样本进行检测，检测指标包括RSV pre-F和post-F蛋白特异性抗体滴度，为疫苗免疫原性和攻毒保护作用分析提供数据支撑。
2）关键试剂
包被工作液：RSV-pre-F-11 蛋白（Vazyme，Cat. No.: RM2187）；RSV-post-F-11蛋白（Vazyme，Cat. No.: RM2188）；
阳性质控：RSV-pre-F0特异性单抗（Monoclonal Anti-RSV-pre-F0 specificAntibody*）（Acro，Cat. No.: RS0-Y132）；RSV-post-F0特异性单抗（Monoclonal Anti-RSV-post-F0 specific Antibody*）（Acro，Cat. No.: RSV-Y180）；
二抗：HRP标记兔抗小鼠IgG二抗（Rabbit Anti-Mouse IgG HL（HRP））（Abcam，Ab6728）；
3）数据计算公式
平均值（Mean）：Mean=Average(OD值X1：OD值Xn)；
信噪比（SNR）：SNR=样本平均OD值/NC平均OD值；
变异系数（CV%）：CV%=STDEV(OD值X1：OD值Xn）/平均OD值*100；
结合抗体滴度计算 ：使用FORECAST(x, known_y’s, known_x’s)函数计算每个分析批中的滴度值，其中x为Cut off值，known_y’s为横跨Cut off值的两个稀释倍数，known_x’s为横跨Cut off值的两个OD值，得到的相应稀释倍数即为每个样本的滴度值。
4）实验流程
同实施例5中ELISA检测方法，在一抗孵育步骤中，加入稀释后的待测血清样本，封板膜密封后，置于酶标恒温振荡器上，37 °C，400 rpm，孵育1.5 h。
1.9 实施例9：RSV F抗原突变体在棉鼠体内免疫原性研究
为探究RSV F抗原在棉鼠体内产生的抗体滴度，以及攻毒后的免疫保护效果，本实施例对棉鼠进行体内免疫。
1.9.1 棉鼠免疫
1）实验材料
动物：棉鼠，雌性，6~8周；
阴性对照：LNP样品；
阳性对照：AbrysvoTM；
受试物：YK-RSV-001、 YK-RSV-061、YK-RSV-062、YK-RSV-003、YK-RSV-012、YK-RSV-015、YK-RSV-036、YK-RSV-039、YK-RSV-044、YK-RSV-054、YK-RSV-060；
2）棉鼠免疫接种方案
注：给药体积根据给药剂量实际浓度计算。AbrysvoTM注射剂量包括A型和B型各25μg。
3）组织样品采集
第54天无菌取肺、鼻甲组。
4）攻毒信息
第49天进行攻毒，攻毒途径为滴鼻，毒株为RSV A2病毒，攻毒体积为50 μl（5×105PFU）。
1.9.2 棉鼠血清RSV结合抗体和中和抗体滴度测定
结合抗体和中和抗体滴度检测方法同实施例4.8.2和4.8.3。
1.9.3 蚀斑法检测棉鼠组织样本中呼吸道合胞病毒（RSV）滴度
1）检测目的
使用蚀斑法测定棉鼠左肺和鼻甲组织样本中呼吸道合胞病毒（RSV）滴度，完成所有生物样本的检测。
2）关键试剂
一抗：帕利珠单抗（Research Grade Palivizumab）（武汉科斯坦，Cat. No.:CSD00024）；
二抗：兔抗人IgG H&L(HRP)（Abcam，Cat. No.: ab6759）；
质控病毒RSV A2；
3）实验过程
通过对待测样本进行梯度稀释后侵染细胞，移除侵染液后，加入覆盖层溶液，继续培养至形成蚀斑，根据蚀斑或病变的出现情况最终计算得到组织样本中病毒滴度的结果。操作流程如下：
细胞准备和种板：HEp-2细胞购自上海誉驰生物。实验前进行复苏和培养，检测时使用的代次为复苏后3~20代。提前将细胞消化接种至24孔板中，2×105cells/ml，1 ml/孔，置于37 °C、5% CO2培养箱培养17 h~23 h。
组织样本处理：取得左肺和鼻甲骨组织样本后，加入病毒维持液，进行组织研磨，样本离心取上清，并进行梯度稀释。
细胞处理：从37℃二氧化碳培养箱取出提前接种的细胞板，吸弃培养上清，加入1×PBS重复洗2遍，吸弃残留的液体；
病毒侵染和吸附：取稀释后的组织匀浆液上清，加入细胞板对应孔中，将24孔板放入37 °C、5% CO2培养箱中，使病毒充分吸附于细胞；
加覆盖层：吸附结束后吸弃病毒液，每孔加入覆盖层，将细胞板放入37 °C、5% CO2培养箱培养，每日观察病变和蚀斑形成情况；
固定：待病毒孔出现典型蚀斑后，吸弃覆盖层，每孔加入4%多聚甲醛进行固定；
染色：细胞板固定后弃固定液，用1×PBS重复洗涤3次，加入封闭液进行封闭；弃封闭液，用1×PBS重复洗涤3次，加入一抗工作液进行孵育；弃抗体，用1×PBS重复洗涤3次，加入HRP二抗工作液进行孵育；弃抗体，用1×PBS重复洗涤3次，加入显色液，室温孵育10-20min；弃显色液，胶片机观察计数斑点；
结果计算:
病毒滴度[PFU/mL]=(蚀斑数平均值×样本稀释倍数）/接种量(mL)；
组织病毒滴度[PFU/g]1*=[ (蚀斑数平均值×组织样本稀释倍数）/接种量(mL)×组织研磨液体积(mL) ]/组织重量（g）。
组织病毒Lg滴度[Lg PFU/g]为以10为底，组织病毒滴度[PFU/g]的对数。
1*：选择可准确计数的全部稀释度的蚀斑进行统计计算，计算时采用算数平均值。
1.9.4 HE染色检测肺组织炎症指标
1）检测目的
应用HE染色检测肺组织炎症指标。
2）关键试剂
二甲苯溶液（上海展云化工有限公司，Cat. No.: 1330-20-7）；苏木素溶液(Mayer)（贝索，Cat. No.: BASO-BA-4021）；伊红溶液（醇溶性）（贝索，Cat. No.: BASO-BA-4022）；
3）实验步骤
将肺组织进行灌注后固定于4%多聚甲醛24小时以上，进行脱水，以最大实质面积进行切片，切片厚度4 μm，将装载切片的染色架放置于60-65 °C烘箱内烤片1个小时，待石蜡融化至透明液态, 将染色架放置于室温环境10分钟进行冷却，冷却完成后，HE染色，最后进行封片。
4）结果
进行人工半定量评分，评分标准如下表。数据以Mean+SEM统计，采用one-wayANOVA进行分析。
2. 结果分析
2.1 RSV F抗原突变体表达结果
YK-RSV-001、YK-RSV-002、YK-RSV-003、YK-RSV-004、YK-RSV-005、YK-RSV-008、YK-RSV-009、YK-RSV-010、YK-RSV-011、YK-RSV-012、YK-RSV-013、YK-RSV-014、YK-RSV-015、YK-RSV-016、YK-RSV-017、YK-RSV-018、YK-RSV-019、YK-RSV-022、YK-RSV-029、YK-RSV-030、YK-RSV-031、YK-RSV-032、YK-RSV-033、YK-RSV-034、YK-RSV-035、YK-RSV-036、YK-RSV-037、YK-RSV-038、YK-RSV-039、YK-RSV-040、YK-RSV-041、YK-RSV-042、YK-RSV-043、YK-RSV-044、YK-RSV-045、YK-RSV-046、YK-RSV-048、YK-RSV-050、YK-RSV-051、YK-RSV-052、YK-RSV-053、YK-RSV-054、YK-RSV-055、YK-RSV-056、YK-RSV-057、YK-RSV-058、YK-RSV-059、YK-RSV-060、YK-RSV-061和YK-RSV-062突变体均有明显的蛋白表达，大小约为75 kDa，与抗原理论大小一致，可以作为下一步免疫原性筛选和评价的有效候选抗原。因此，以上50个突变体将进一步通过流式细胞术测定抗原表位结合以进一步筛选。
2.2 RSV F抗原突变体表位结合测定结果
在RSV F蛋白的主要中和活性抗原表位中，Φ表位仅位于融合前构象，II表位在融合前和融合后构象均保留。
抗体与Φ表位特异性结合的能力与中和活性相关，Φ表位结合率低，进而影响中和活性，导致中和活性较差。
本实施例中使用的RSV pre-F抗体（3C12）特异性结合RSV pre-F Φ表位，RSV F抗体（11A9）结合pre-F和post-F II表位，通过流式细胞术检测突变体上的Φ表位和II表位分别与对应的抗体3C12和11A9表位结合，可以进一步推断RSV F突变体融合前构象是否稳定。表位结合数据如下表所示。
RSV F突变体上的Φ表位与抗体3C12结合率高于90%的突变体共有20个，这些突变体上的Φ表位与抗体3C12结合率均优于对照PC-RSV-064、PC-RSV-065、PC-RSV-066、PC-RSV-067、PC-RSV-068以及野生型RSV A2 (138251)-wt。
1）以下11个 RSV F突变体上的Φ表位与抗体3C12结合率高于90%，分布在91.6%~94.9%，并且显著优于对照
该范围内突变体如下表所示，包括YK-RSV-061、YK-RSV-003、YK-RSV-062、YK-RSV-054、YK-RSV-039、YK-RSV-044、YK-RSV-012、YK-RSV-015、YK-RSV-001、YK-RSV-036、YK-RSV-060。
2）以下9个 RSV F突变体上的Φ表位与抗体3C12的结合率也都高于90%，并且显著优于对照
下表中9个突变体上的Φ表位与抗体3C12的结合率为90.3%~94.6%，该范围内的突变体如下表所示。
3）以下15个RSV F突变体上的Φ表位与抗体3C12的结合率为80%~90%，优于对照或与其效果相当
该范围内的突变体如下表所示。这些突变体上的Φ表位与抗体3C12的结合率为81.2%~89.6%，Ⅱ表位与抗体11A9的结合率为88.7%~95.1%，Φ/Ⅱ比值为90.7%~95.4%。
RSV F突变体上的Φ表位与抗体3C12的结合率低于80%的突变体共有15个。
4）7个RSV F突变体上的Φ表位与抗体3C12的结合率低于80%
以下7个突变体上的Φ表位与抗体3C12的结合率为76.8%~79.8%，Ⅱ表位与抗体11A9的结合率为83.4%~87.1%，Φ/Ⅱ比值为88.2%~95.7%，该范围内的突变体如下表所示。
综上所述，以上筛选的42个突变体（见表8、表9、表10和表11）上的Φ表位与对应抗体的结合率相对较高。
2.3 RSV F抗原突变体稳定性筛选结果
RSV F融合前构象处于亚稳定状态，可以自发地重新排列成高度稳定的融合后构象。在细胞进入期间从融合前构象转变为融合后构象的触发因素尚不清楚。然而，当用表面活性剂诸如Triton X-100、Triton X-114、NP-40、Brij-35、Brij-58、Tween 20、Tween 80、辛基葡糖苷、辛基硫代葡糖苷、SDS、CHAPS、CHAPSO从膜中提取F蛋白时，或表达为胞外结构域，物理或化学应激或储存后，F糖蛋白容易转变为融合后构象（J. S. McLellan等，2013；J. O. Ngwuta等，2015）。RSV F处于融合前构象有助于疫苗诱导或增强中和活性，而物理稳定性直接影响蛋白构象，因此，本实施例通过不同处理条件，筛选稳定性较优的抗原。
本实施例中，突变体通过不同的处理条件进行稳定性筛选被定义为应激测试，应激测试包括，4°C低温储藏一周；50°C孵育60 min；室温下低渗透压和高渗透压条件处理60min；室温下酸和碱条件处理60 min。ELISA检测突变体与识别Φ表位的RSV pre-F抗体（3C12）结合。本实施例中应激抗性参数计算如下：
应激抗性参数=应激后的样品与抗体结合量÷未应激的样品与抗体结合量；
预期更稳定的突变体具有较高应激抗性。稳定性筛选结果如下：
1）不同应激测试下，突变体均保留与抗体的结合能力。
从ELISA检测结果看，不同应激测试后突变体依然保持与RSV pre-F抗体（3C12）的亲和性，因为RSV pre-F 抗体（3C12）特异性与RSV F蛋白融合前构象Φ表位结合，表明不同应激测试后，突变体仍然可以稳定在融合前构象。
2）一些突变体在应激测试后稳定性仍很强。
通过对所有突变体稳定性结果进行组间分析发现，当在4°C储藏一周后应激抗性参数低于0.4，50°C孵育60 min后应激抗性参数低于0.5，高渗透压处理60 min后应激抗性参数低于0.5，低渗透压处理60 min后应激抗性参数低于0.5的突变体在组间表现为相对显著的差异性，因此作为抗原筛选的标准。
。
以下突变体在4 °C储藏一周后应激抗性参数在0.44以上，高达0.86；在50 °C孵育60 min后应激抗性参数在0.64以上；在高渗透压条件下处理60 min 后应激抗性参数在0.61以上；在低渗透压条件下处理60 min 后应激抗性参数为0.70以上；在pH=3.5和pH=10条件下处理60 min后应激抗性参数均为0.56以上，不同条件处理后的应激抗性参数均优于对照或与其效果相当。
。
3）总结：
①从物理稳定性筛选结果来看，与对照相比，稳定性在某些应激测试下有明显改善，且与其它突变体组间相比，20个突变体（包括YK-RSV-061、YK-RSV-003、YK-RSV-062、YK-RSV-054、YK-RSV-039、YK-RSV-044、YK-RSV-012、YK-RSV-015、YK-RSV-001、YK-RSV-036、YK-RSV-060、YK-RSV-009、YK-RSV-010、YK-RSV-011、YK-RSV-030、YK-RSV-043、YK-RSV-048、YK-RSV-050、YK-RSV-055、YK-RSV-057）在每种应激测试下具有更优的稳定性，表现为综合稳定性较强。以下通过ELISA进一步检测其与不同表位抗体的结合能力。
2.4 RSV F抗原突变体与识别不同表位的抗体ELISA检测结果
在本申请涉及到的Φ、Quaternary、V、II和III表位中，相较于II和Ⅲ表位在融合前构象和融合后构象都存在，识别Φ、Quaternary和V表位抗体只特异性结合融合前构象，且研究已证实只在融合前构象中存在的特异性表位是中和抗体敏感的位点，能诱导更高的中和抗体反应。
本申请通过ELISA检测不同突变体抗原分别与识别不同表位的抗体结合，通过结合量的高低衡量抗原和抗体结合的强弱。其中，（1）识别Φ表位的RSV pre-F 抗体（3C12）只与融合前构象的F蛋白发生结合；（2）RSV pre-F 抗体（7H11）识别Quaternary 表位（横跨IV和V两个表位），与融合前构象的F蛋白发生特异性结合；（3）识别II表位的RSV F 抗体（11A9）可以同时识别F蛋白的融合前和融合后构象；（4）识别III表位的RSV F 抗体（4B9）则偏好识别融合前构象，与融合后构象具有较弱的结合活性；（5）识别V表位的RSV pre-F抗体(7E11) 只与融合前构象的F蛋白发生结合。ELISA检测结果如下所示。
1）以下11个突变体上的Φ表位、Quaternary 表位、V表位与对应的抗体均能良好结合，结合能力较强，II表位和/或III表位与对应抗体的结合水平优于对照或与其相当。
例如，YK-RSV-061、YK-RSV-003和YK-RSV-062上的Φ表位与RSV pre-F 抗体(3C12) 的结合水平是对照PC-RSV-064的1.83~2.00倍；Quaternary表位与RSV pre-F 抗体（7H11）的结合水平是对照PC-RSV-064的2.01~2.12倍。
YK-RSV-054上的Φ表位与RSV pre-F 抗体(3C12) 的结合水平是对照PC-RSV-064的2.52倍；Quaternary 表位与RSV pre-F 抗体(7H11) 的结合水平是对照PC-RSV-064的1.82倍；V表位与RSV F 抗体(7E11) 的结合水平是对照PC-RSV-064的3.30倍；II表位与RSVF 抗体(11A9) 的结合水平是对照PC-RSV-064的1.79倍；III表位与RSV F 抗体(4B9) 的结合水平是对照PC-RSV-064的2.27倍。
。
2）以下4个突变体上的Φ表位、Quaternary 表位、V表位和对应抗体也能良好结合，结合能力也较强。
例如，YK-RSV-011上的Φ表位与RSV pre-F 抗体（3C12）的结合水平是对照PC-RSV-064的2.90倍；Quaternary 表位与RSV pre-F 抗体(7H11) 的结合水平是对照PC-RSV-064的1.81倍；V表位与RSV F 抗体(7E11) 的结合水平是对照PC-RSV-064的2.70倍；II表位与RSV F 抗体(11A9) 的结合水平是对照PC-RSV-064的2.09倍；III表位与RSV F 抗体(4B9) 的结合水平是对照PC-RSV-064的2.47倍。
。
综上所述，上述内容检测了突变体上的5种不同表位与对应抗体的结合水平，结合水平较好的突变体（见表16和表17）进一步进行候选抗原筛选。
2.5 RSV F抗原突变体与识别不同表位抗体的亲和力检测结果
生物膜干涉技术（Bio-Layer Interferometry，简称BLI）是一种无标记的、实时监测的光学检测技术，主要用于生物分子间相互作用的全方位定量分析以及蛋白浓度测定。BLI可实时监控分子间的结合过程，并计算出分子之间的亲和力常数（KD）、结合速率常数（Kon或ka）、解离速率常数（Koff、Kdis或kd）等重要数据。
KD=Koff÷ Kon；
KD：指亲和力常数，表示两个结合的强弱，KD越大结合越弱，反之越强；
Kon：指结合速率常数；
Kdis（Koff）：指解离速率常数；
Kon，Koff主要体现分子相互作用的模式，是快结合快解离还是慢结合慢解离等。
本申请采用BLI方法分析目的蛋白和2种抗体的亲和力，其中，RSV pre-F 抗体（3C12）识别Φ表位，RSV pre-F 抗体（7H11）识别Quaternary表位。检测结果如下所示：
。
1）以下突变体，与抗体结合的亲和力最强，并且显著优于对照
以下突变体上的Φ表位与RSV pre-F 抗体（3C12）结合的亲和力常数KD为3.26E-12~7.79E-11 M，显著低于对照的KD值（KD为E-10 M，相差1~2个数量级），表明抗原和抗体的亲和力较强。
突变体上的Quaternary表位与RSV pre-F 抗体（7H11）结合的亲和力常数KD为3.05E-12~6.13E-10 M，除YK-RSV-044、YK-RSV-060和YK-RSV-030与对照KD值相当外，其余突变体KD值均显著低于对照（相差1~2个数量级），表明抗原和抗体的亲和力较强。
以下突变体将进行动物实验进一步筛选。
。
2.6 RSV F抗原突变体在Balb/c小鼠中免疫原性结果
小鼠体积小、生长速度快、饲养成本低，市售检测试剂较多，基于上述原因，目前小鼠在RSV感染动物模型中应用最多。1979年Prince首次报道小鼠作为hRSV感染动物模型，使用较多的为Balb/c小鼠，经腔滴感染RSV滴度为105~107PFU，动物可见明显下呼吸道炎症改变，气管灌注液中部分细胞因子和CC/CXC趋化因子如TNF-α、IL-6、IFN-γ等明显增加，组织病理学可见细支气管周和细血管周围单核细胞（淋巴细胞、巨噬细胞）渗出或问质性肺炎。小鼠感染RSV亚型不同（如Along，A2和临床分离株等）症状不同。小鼠感染RSV后出现呼吸频率加快，并伴有气道阻塞和气道高反应性，且气道的高反应性会持续较长时间，与儿童感染RSV很相似，并且小鼠是药理毒理学研究最常用的模型动物之一，遗传背景清楚，品系较多，并可通过基因靶向转染或敲除技术满足特定试验需求。因此，下述实验采用小鼠作为动物模型进行检测。
2.6.1 结合抗体滴度检测结果
采用ELISA法检测小鼠免疫后第35天血清中融合前和融合后F蛋白特异性IgG 滴度，检测结果如下表所示：
1、下述11个受试物的pre-F IgG抗体滴度是AbrysvoTM阳性对照的2.52 ~5.31倍，post-F IgG抗体滴度是AbrysvoTM阳性对照的1.13 ~5.21倍。
YK-RSV-061、YK-RSV-003、YK-RSV-062三者pre-F IgG抗体滴度是AbrysvoTM阳性对照的4.29 ~5.31倍，post-F IgG抗体滴度是AbrysvoTM阳性对照的4.32 ~5.21倍。
其中，YK-RSV-061 突变体的pre-F IgG抗体滴度最高，pre-F IgG抗体滴度高达AbrysvoTM阳性对照的5.31倍，post-F IgG抗体滴度是AbrysvoTM阳性对照的5.21倍。
在所有检测的受试物中，pre-F/post-F比值均高于1，表明其融合前构象F蛋白比融合后构象F蛋白产生的IgG滴度要高。
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2、YK-RSV-011和YK-RSV-030，二者pre-F IgG抗体滴度是AbrysvoTM阳性对照的2.38~2.50倍，post-F IgG抗体滴度是AbrysvoTM阳性对照的1.30 ~2.81倍。
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以上受试物将进一步通过测定产生的中和抗体水平对其免疫原性进行评价。
2.6.2 中和抗体滴度检测结果
采用基于斑点减少的微量中和试验法检测小鼠免疫后第35天血清中和抗体滴度，检测结果如下表以及图4~图7（分别包括图（A）和图（B））所示：
下述11个受试物的中和抗体滴度IC50为AbrysvoTM阳性对照的3.72 ~12.67倍，IC90为AbrysvoTM阳性对照的2.34~14.41倍，均高于阳性对照。
YK-RSV-061、YK-RSV-003、YK-RSV-062三者的中和抗体滴度IC50为AbrysvoTM阳性对照的6.34 ~12.67倍，IC90为AbrysvoTM阳性对照的9.56~14.41倍，中和抗体滴度显著较高。
其中，YK-RSV-061中和抗体滴度最高，IC50是AbrysvoTM阳性对照的12.67倍，IC90为是阳性对照的14.41倍。
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2、RSV B型病毒-中和抗体滴度结果
采用上述筛选得到的11个受试物进一步检测其对RSV B18357病毒所产生的中和抗体水平，检测结果如下表所示：
下述11个突变体的中和抗体滴度IC50为AbrysvoTM阳性对照的2.85 ~10.63倍，IC90为AbrysvoTM阳性对照的2.88 ~14.23倍，中和抗体滴度均显著高于阳性对照。
YK-RSV-061、YK-RSV-003、YK-RSV-062三者的中和抗体滴度IC50为AbrysvoTM阳性对照的5.68~10.63倍，IC90为AbrysvoTM阳性对照的6.87~14.23倍，中和抗体滴度非常高。
其中，YK-RSV-061中和抗体滴度最高，IC50是AbrysvoTM阳性对照的10.63倍，IC90为是阳性对照的14.23倍。
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综上所述，上述11个受试物（包括YK-RSV-061、YK-RSV-003、YK-RSV-062、YK-RSV-054、YK-RSV-039、YK-RSV-044、YK-RSV-012、YK-RSV-015、YK-RSV-001、YK-RSV-036和YK-RSV-060）针对RSV A2和RSV B18357不同亚型均能产生较高的中和抗体滴度。
2.7 RSV F抗原突变体在棉鼠中免疫原性结果
1971年Dreizin首次报道了棉鼠作为hRSV病毒感染的动物模型，棉鼠感染hRSV后，病毒主要在肺部和下呼吸道复制扩增，病理学检查可见轻到中度细支气管炎或肺炎、气道上皮细胞脱落和肺不张，上呼吸道感染症状较明显，相关细胞因子变化不明显。棉鼠是疫苗、抗病毒药和单抗(如:帕利珠单抗)有效性评价的标准动物模型。因此，下述实验采用棉鼠作为动物模型进行检测。
2.7.1 结合抗体滴度检测结果
采用ELISA法检测棉鼠免疫后第42、48天血清中融合前和融合后F蛋白特异性IgG滴度（参见图8~图11（分别包括图（A）和图（B）），第42天IgG 滴度检测结果如下表所示：
（1）第42天，下述11个受试物的pre-F IgG抗体滴度是AbrysvoTM阳性对照的3.05~13.10倍，post-F IgG抗体滴度是AbrysvoTM阳性对照的2.36 ~6.38倍，均显著高于阳性对照。
YK-RSV-061、YK-RSV-003、YK-RSV-062三者pre-F IgG抗体滴度是AbrysvoTM阳性对照的9.76~13.10倍，post-F IgG抗体滴度是AbrysvoTM阳性对照的4.66~6.33倍。
其中，YK-RSV-061 受试物的IgG抗体滴度最高，pre-F IgG抗体滴度高达AbrysvoTM阳性对照的13.10倍，post-F IgG抗体滴度是AbrysvoTM阳性对照的6.33倍。
所有受试物pre-F/post-F比值范围为1.39~3.95，表明融合前F蛋白产生的IgG抗体滴度显著高于融合后F蛋白。
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同时检测棉鼠血清中第48天IgG 滴度，检测结果如下表所示：
（2）第48天，下述11个受试物的pre-F IgG抗体滴度是AbrysvoTM阳性对照的4.44~12.35倍，post-F IgG抗体滴度是AbrysvoTM阳性对照的1.51~6.83倍，均显著高于阳性对照。
YK-RSV-061、YK-RSV-003、YK-RSV-062三者pre-F IgG抗体滴度是AbrysvoTM阳性对照的9.02~12.35倍，post-F IgG抗体滴度是AbrysvoTM阳性对照的4.03~6.83倍。
其中，YK-RSV-061 受试物的IgG抗体滴度最高，pre-F IgG抗体滴度高达AbrysvoTM阳性对照的12.35倍，post-F IgG抗体滴度是AbrysvoTM阳性对照的6.83倍。
所有受试物pre-F/post-F比值范围为1.78-4.29 倍，表明第48天免疫后，融合前F蛋白产生的IgG抗体滴度仍然显著高于融合后F蛋白。
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2.7.2 中和抗体滴度检测结果
分别在第42、48天检测了棉鼠血清中针对RSV A2病毒所产生的中和抗体滴度（参见图12（A）和（B）、图13（A）和（B）、图16（A）和（B）、图17（A）和（B）），第42中和抗体滴度检测结果如下表所示：
（1）免疫后第42天，从棉鼠血清中检测到下述11个受试物的中和抗体滴度IC50为AbrysvoTM阳性对照的2.10 ~14.30倍，IC90为AbrysvoTM阳性对照的2.26~22.33倍，均显著高于阳性对照。
YK-RSV-061、YK-RSV-003、YK-RSV-062三者的中和抗体滴度IC50为AbrysvoTM阳性对照的8.84~14.30倍，IC90为AbrysvoTM阳性对照的16.46 ~22.33倍。
其中，YK-RSV-061 IC50是AbrysvoTM阳性对照的14.30倍，IC90为是阳性对照的22.33倍，中和抗体滴度最高。
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（2）同时检测第42天棉鼠血清中针对RSV B病毒所产生的中和抗体滴度，检测结果如下表、图14（A）和（B）以及图15（A）和（B）所示：
下述11个受试物的中和抗体滴度IC50为AbrysvoTM阳性对照的2.16~14.63倍，IC90为AbrysvoTM阳性对照的2.49~17.26倍，均显著高于阳性对照。
YK-RSV-061、YK-RSV-003、YK-RSV-062三者的中和抗体滴度IC50为AbrysvoTM阳性对照的11.52~14.63倍，IC90为AbrysvoTM阳性对照的13.44~17.26倍。
其中，YK-RSV-061 IC50是AbrysvoTM阳性对照的14.63倍，IC90为是阳性对照的17.26倍，中和抗体滴度最高。
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（3）免疫后第48天，检测了棉鼠血清中针对RSV A2病毒所产生的中和抗体滴度，检测结果如下表所示：
下述11个受试物的中和抗体滴度IC50为AbrysvoTM阳性对照的1.70 ~7.57倍，IC90为AbrysvoTM阳性对照的1.46~11.56倍，均高于阳性对照。
YK-RSV-061、YK-RSV-003、YK-RSV-062三者的中和抗体滴度IC50为AbrysvoTM阳性对照的4.51 ~7.57倍，IC90为AbrysvoTM阳性对照的8.75~11.56倍。
其中，YK-RSV-061 IC50是AbrysvoTM阳性对照的7.57倍，IC90为是阳性对照的11.56倍，中和抗体滴度最高。
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综上所述，棉鼠免疫后第42天和第48天，所有受试物产生的结合抗体和中和抗体滴度水平都显著高于对照AbrysvoTM，体液免疫效果提升显著。其中，受试物YK-RSV-061免疫效果最好。所有受试物针对不同亚型（包括RSV A型和B型）的病毒也具有良好的免疫效果。
2.7.3 棉鼠肺部病理切片结果
棉鼠肺部病理切片如图18所示，评分结果如下表所示：
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由以上结果可见，受试物细支气管周浸润评分均在0.33~0.83间，为轻度炎症浸润。
所有受试物间质浸润评分均优于阳性对照AbrysvoTM，评分为0.67~1.17，为轻度炎症浸润。
所有受试物整体炎性反应评分低，病理总评分在1.00~2.00间，均低于对照LNP。其中，对照和受试物血管周浸润和肺泡浸润两项指标评分均为0，该组织无可见病灶。
2.7.4 棉鼠肺部和鼻甲骨病毒载量结果
在第54天对棉鼠处死后，无菌取肺部和鼻甲骨组织进行病毒滴度测定，检测结果如下表所示。
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对棉鼠肺部病毒载量进行测定，结果表明，阴性对照LNP免疫后组织病毒载量为4.52，显著高于阳性对照AbrysvoTM和其它受试物。其中，对照AbrysvoTM免疫后组织病毒载量为2.14，其它受试物免疫后组织病毒载量为1.61~2.08，低于阳性对照AbrysvoTM。
对棉鼠鼻甲骨病毒载量进行测定，结果表明，阴性对照LNP免疫后组织病毒载量为4.12，显著高于其它受试物。其中，对照AbrysvoTM免疫后组织病毒载量为3.35，其它受试物免疫后组织病毒载量为0.62~1.51，仅为阳性对照AbrysvoTM的0.19~0.45倍，病毒载量显著降低，表明受试物具有较好的抗病毒效果。
2.8 突变体差异分析
综上所述，本发明通过设计52个编码RSV F蛋白突变体的抗原序列，共筛选出至少11条（YK-RSV-061、YK-RSV-003、YK-RSV-062、YK-RSV-054、YK-RSV-039、YK-RSV-044、YK-RSV-012、YK-RSV-015、YK-RSV-001、YK-RSV-036、YK-RSV-060），尤其是其中至少5条（YK-RSV-061、YK-RSV-003、YK-RSV-062、YK-RSV-054、YK-RSV-039）比阳性对照AbrysvoTM和设计对照PC-RSV-063、PC-RSV-064、PC-RSV-065、PC-RSV-066、PC-RSV-067、PC-RSV-068效果均优异的抗原序列。
（1）
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与YK-RSV-003突变体相比，YK-RSV-061在其基础上增加了1个位点突变V152I；YK-RSV-062在其基础上增加了5个位点突变C69Y、D73E、A74V、N88S和V152I；
YK-RSV-003、YK-RSV-061和YK-RSV-062三个突变体上的表位均和对应抗体具有良好的结合水平。例如，YK-RSV-061、YK-RSV-003和YK-RSV-062上的Quaternary表位与RSVpre-F 抗体（7H11）的结合水平是对照PC-RSV-064的2.01~2.12倍。
但是，针对RSV A型病毒，YK-RSV-061的中和抗体滴度IC50和IC90分别高达AbrysvoTM阳性对照的12.67和14.41 倍，而YK-RSV-003中和抗体滴度IC50和IC90分比为AbrysvoTM阳性对照的7.39和9.59倍，二者虽然仅相差 1个位点突变V152I，但YK-RSV-061的中和抗体滴度显著提高，这是出乎意料的结果。YK-RSV-062的中和抗体滴度与YK-RSV-003效果相当。同理，针对RSV B型病毒，YK-RSV-061的中和抗体滴度也具有明显优势。
（2）
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与YK-RSV-003突变体相比，对照PC-RSV-063改变了位点突变中组2中1个突变类型，由V296I替换为V207L；删除位点突变中组3中D486S位点突变。但是YK-RSV-003上的Quaternary表位与RSV pre-F 抗体（7H11）的结合水平是对照PC-RSV-063的2.04倍，结合水平差异显著。
与YK-RSV-061突变体相比，对照PC-RSV-065和PC-RSV-066分别减少了1个位点突变(D486S或V296I)，对照PC-RSV-064减少了2个位点突变(D486S和V296I)，对照PC-RSV-067和PC-RSV-068改变了位点突变中组1中的突变类型，结果显示：YK-RSV-061突变体上的Φ表位与RSV pre-F 抗体（3C12）结合的亲和力常数KD为6.21E-11 M；Quaternary表位与RSVpre-F 抗体（7H11）结合的亲和力常数KD为3.05E-12 M，其他对照的KD值均为E-10 M，相差1~2个数量级，表明抗原YK-RSV-061和抗体的亲和力均高于其他对照。
通过上述对比可知，YK-RSV-003突变体上的表位与对应抗体的结合水平和结合力均显著高于对照PC-RSV-063~ PC-RSV-068；与此同时，结合第（1）部分对比结果，YK-RSV-061突变体的效果显著优于YK-RSV-003突变体，YK-RSV-062与YK-RSV-003效果相当，因此，YK-RSV-061、YK-RSV-003和YK-RSV-062均优于对照PC-RSV-063~ PC-RSV-068。
下表为本申请完整的序列信息及其编号，以YK-RSV-001的抗原序列为例，其中，SEQ NO ID:3和4分别为抗原YK- RSV -001的开放阅读框的DNA序列以及氨基酸序列；SEQNO ID:2和5分别为抗原YK- RSV -001的DNA序列及mRNA序列。
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现将本公开中的全部序列列在下面：
RSV A2 (138251)-wt SEQ ID NO: 1
MELLILKANAITTILTAVTFCFASGQNITEEFYQSTCSAVSKGYLSALRTGWYTSVITIELSNIKENKCNGTDAKVKLIKQELDKYKNAVTELQLLMQSTPPTNNRARRELPRFMNYTLNNAKKTNVTLSKKRKRRFLGFLLGVGSAIASGVAVSKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTSKVLDLKNYIDKQLLPIVNKQSCSISNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMSIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSLTLPSEINLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGMDTVSVGNTLYYVNKQEGKSLYVKGEPIINFYDPLVFPSDEFDASISQVNEKINQSLAFIRKSDELLHNVNAGKSTTNIMITTIIIVIIVILLSLIAVGLLLYCKARSTPVTLSKDQLSGINNIAFSN
2. YK-RSV-001 DNA, SEQ ID NO: 2
AGCGGCTCGGCCATTTTGTCCCAGTCAGTCCGGAGGCTGCGGCTGCAGAAGTACCGCCTGCGGAGTAACTGCAAAGGCCACCATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCAGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCAGCGCCATTTGTTCTGGTGTCGCCGTGTGCAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCATCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCGTCAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGTGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTGCGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCAGCGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAGGCTGGAGCCTCGGTGGCCATGCTTCTTGCCCCTTGGGCCTCCCCCCAGCCCCTCCTCCCCTTCCTGCACCCGTACCCCCGTGGTCTTTGAATAAAGTCTGAGTGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
3. YK-RSV-001 ORF NT, SEQ ID NO: 3
ATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCAGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCAGCGCCATTTGTTCTGGTGTCGCCGTGTGCAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCATCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCGTCAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGTGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTGCGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCAGCGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAG
4. YK-RSV-001 ORF AA, SEQ ID NO: 4
MELLILKANAITTILTAVTFCFASGQNITEEFYQSTCSAVSKGYLGALRTGWYTSVITIELSNIKENKCNGTDAKVKLIKQELDKYKNAVTDLQLLMQSTPATGSGSAICSGVAVCKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTIKVLDLKNYIDKQLLPIVNKQSCSIPNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMCIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSRTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYCVNKQEGQSLYVKGEPIINFYDPLVFPSSEFDASISQVNEKINQSLAFIRKSDELLHNVNAGKSTTNIMITTIIIVIIVILLSLIAVGLLLY
5. YK-RSV-001 mRNA, SEQ ID NO: 5
AGCGGCUCGGCCAUUUUGUCCCAGUCAGUCCGGAGGCUGCGGCUGCAGAAGUACCGCCUGCGGAGUAACUGCAAAGGCCACCAUGGAACUGCUGAUCCUGAAGGCCAACGCCAUCACCACCAUCCUGACCGCCGUGACCUUCUGUUUUGCCAGCGGCCAGAACAUCACCGAGGAAUUCUACCAGAGCACCUGUAGCGCCGUGUCCAAGGGAUAUCUGGGCGCCCUUAGAACCGGCUGGUACACCAGCGUGAUCACCAUCGAGCUGAGCAACAUCAAAGAAAACAAGUGCAACGGCACCGACGCCAAAGUGAAGCUGAUCAAGCAAGAGCUGGACAAGUACAAGAAUGCCGUGACCGACCUGCAGCUGCUGAUGCAGUCUACACCAGCCACAGGCUCUGGCAGCGCCAUUUGUUCUGGUGUCGCCGUGUGCAAAGUGCUGCACCUGGAAGGCGAAGUGAACAAGAUCAAGAGCGCCCUGCUGAGCACCAACAAGGCCGUGGUGUCUCUGAGCAAUGGCGUGUCCGUGCUGACCAUCAAGGUGCUGGACCUGAAGAACUACAUCGACAAACAGCUGCUGCCCAUCGUCAACAAGCAGUCCUGCAGCAUCCCCAACAUCGAGACAGUGAUCGAGUUCCAGCAGAAGAACAACCGGCUGCUGGAAAUCACCCGCGAGUUCUCUGUGAAUGCCGGCGUGACCACACCUGUGUCCACCUACAUGCUGACCAACAGCGAGCUGCUGAGCCUGAUCAACGACAUGCCCAUCACCAACGACCAGAAAAAGCUGAUGAGCAACAACGUGCAGAUCGUGCGGCAGCAGAGCUACAGCAUCAUGUGCAUUAUCAAAGAAGAGGUGCUGGCCUACGUGGUGCAGCUGCCUCUGUAUGGCGUGAUCGAUACCCCUUGCUGGAAGCUGCACACAAGCCCUCUGUGCACCACCAACACCAAAGAGGGCAGCAACAUCUGCCUGACCAGAACCGACAGAGGCUGGUACUGCGAUAAUGCCGGCAGCGUCUCAUUCUUCCCACAAGCCGAGACAUGCAAGGUGCAGAGCAACCGGGUGUUCUGCGACACCAUGAAUAGCAGAACCCUGCCUUCCGAAGUGAAUCUGUGCAACGUGGACAUCUUCAACCCUAAGUACGACUGCAAGAUCAUGACCAGCAAGACCGACGUGUCCAGCAGUGUGAUCACCUCACUGGGCGCCAUCGUGUCCUGUUACGGCAAGACCAAGUGCACCGCCAGCAACAAGAACCGGGGCAUCAUCAAGACCUUCAGCAACGGCUGCGACUACGUGUCCAACAAAGGCGUGGACACCGUGUCUGUGGGCAACACCCUGUACUGCGUGAACAAACAAGAGGGCCAGUCUCUGUACGUGAAGGGCGAGCCCAUCAUCAACUUCUACGACCCUCUGGUGUUCCCCAGCAGCGAGUUCGAUGCCAGCAUCAGCCAAGUGAACGAGAAGAUCAAUCAGAGCCUGGCCUUCAUCAGAAAGUCCGAUGAGCUGCUGCACAACGUGAACGCCGGCAAGUCCACCACCAAUAUCAUGAUCACGACCAUCAUCAUCGUGAUUAUCGUGAUCCUGCUGUCCCUGAUCGCCGUGGGCCUGCUGCUUUAUUGAUAAUAGGCUGGAGCCUCGGUGGCCAUGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCUUCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
6. YK-RSV-002 DNA, SEQ ID NO: 6
AGCGGCTCGGCCATTTTGTCCCAGTCAGTCCGGAGGCTGCGGCTGCAGAAGTACCGCCTGCGGAGTAACTGCAAAGGCCACCATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACCACAGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCAGCGCCATTTGTTCTGGTGTCGCCGTGTGCAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCGTCAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGTGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTGCGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCAGCGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAGGCTGGAGCCTCGGTGGCCATGCTTCTTGCCCCTTGGGCCTCCCCCCAGCCCCTCCTCCCCTTCCTGCACCCGTACCCCCGTGGTCTTTGAATAAAGTCTGAGTGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
7. YK-RSV-002 ORF NT, SEQ ID NO: 7
ATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACCACAGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCAGCGCCATTTGTTCTGGTGTCGCCGTGTGCAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCGTCAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGTGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTGCGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCAGCGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAG
8. YK-RSV-002 ORF AA, SEQ ID NO: 8
MELLILKANAITTILTAVTFCFASGQNITEEFYQSTCSAVSKGYLGALRTGWYHSVITIELSNIKENKCNGTDAKVKLIKQELDKYKNAVTDLQLLMQSTPATGSGSAICSGVAVCKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTFKVLDLKNYIDKQLLPIVNKQSCSIPNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMCIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSRTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYCVNKQEGQSLYVKGEPIINFYDPLVFPSSEFDASISQVNEKINQSLAFIRKSDELLHNVNAGKSTTNIMITTIIIVIIVILLSLIAVGLLLY
9. YK-RSV-002 mRNA, SEQ ID NO: 9
AGCGGCUCGGCCAUUUUGUCCCAGUCAGUCCGGAGGCUGCGGCUGCAGAAGUACCGCCUGCGGAGUAACUGCAAAGGCCACCAUGGAACUGCUGAUCCUGAAGGCCAACGCCAUCACCACCAUCCUGACCGCCGUGACCUUCUGUUUUGCCAGCGGCCAGAACAUCACCGAGGAAUUCUACCAGAGCACCUGUAGCGCCGUGUCCAAGGGAUAUCUGGGCGCCCUUAGAACCGGCUGGUACCACAGCGUGAUCACCAUCGAGCUGAGCAACAUCAAAGAAAACAAGUGCAACGGCACCGACGCCAAAGUGAAGCUGAUCAAGCAAGAGCUGGACAAGUACAAGAAUGCCGUGACCGACCUGCAGCUGCUGAUGCAGUCUACACCAGCCACAGGCUCUGGCAGCGCCAUUUGUUCUGGUGUCGCCGUGUGCAAAGUGCUGCACCUGGAAGGCGAAGUGAACAAGAUCAAGAGCGCCCUGCUGAGCACCAACAAGGCCGUGGUGUCUCUGAGCAAUGGCGUGUCCGUGCUGACCUUCAAGGUGCUGGACCUGAAGAACUACAUCGACAAACAGCUGCUGCCCAUCGUCAACAAGCAGUCCUGCAGCAUCCCCAACAUCGAGACAGUGAUCGAGUUCCAGCAGAAGAACAACCGGCUGCUGGAAAUCACCCGCGAGUUCUCUGUGAAUGCCGGCGUGACCACACCUGUGUCCACCUACAUGCUGACCAACAGCGAGCUGCUGAGCCUGAUCAACGACAUGCCCAUCACCAACGACCAGAAAAAGCUGAUGAGCAACAACGUGCAGAUCGUGCGGCAGCAGAGCUACAGCAUCAUGUGCAUUAUCAAAGAAGAGGUGCUGGCCUACGUGGUGCAGCUGCCUCUGUAUGGCGUGAUCGAUACCCCUUGCUGGAAGCUGCACACAAGCCCUCUGUGCACCACCAACACCAAAGAGGGCAGCAACAUCUGCCUGACCAGAACCGACAGAGGCUGGUACUGCGAUAAUGCCGGCAGCGUCUCAUUCUUCCCACAAGCCGAGACAUGCAAGGUGCAGAGCAACCGGGUGUUCUGCGACACCAUGAAUAGCAGAACCCUGCCUUCCGAAGUGAAUCUGUGCAACGUGGACAUCUUCAACCCUAAGUACGACUGCAAGAUCAUGACCAGCAAGACCGACGUGUCCAGCAGUGUGAUCACCUCACUGGGCGCCAUCGUGUCCUGUUACGGCAAGACCAAGUGCACCGCCAGCAACAAGAACCGGGGCAUCAUCAAGACCUUCAGCAACGGCUGCGACUACGUGUCCAACAAAGGCGUGGACACCGUGUCUGUGGGCAACACCCUGUACUGCGUGAACAAACAAGAGGGCCAGUCUCUGUACGUGAAGGGCGAGCCCAUCAUCAACUUCUACGACCCUCUGGUGUUCCCCAGCAGCGAGUUCGAUGCCAGCAUCAGCCAAGUGAACGAGAAGAUCAAUCAGAGCCUGGCCUUCAUCAGAAAGUCCGAUGAGCUGCUGCACAACGUGAACGCCGGCAAGUCCACCACCAAUAUCAUGAUCACGACCAUCAUCAUCGUGAUUAUCGUGAUCCUGCUGUCCCUGAUCGCCGUGGGCCUGCUGCUUUAUUGAUAAUAGGCUGGAGCCUCGGUGGCCAUGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCUUCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
10. YK-RSV-003 DNA, SEQ ID NO: 10
AGCGGCTCGGCCATTTTGTCCCAGTCAGTCCGGAGGCTGCGGCTGCAGAAGTACCGCCTGCGGAGTAACTGCAAAGGCCACCATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCAGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCAGCGCCATTTGTTCTGGTGTCGCCGTGTGCAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCGTCAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGTGCATTATCAAAGAAGAGATCCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTGCGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCAGCGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAGGCTGGAGCCTCGGTGGCCATGCTTCTTGCCCCTTGGGCCTCCCCCCAGCCCCTCCTCCCCTTCCTGCACCCGTACCCCCGTGGTCTTTGAATAAAGTCTGAGTGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
11. YK-RSV-003 ORF NT, SEQ ID NO: 11
ATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCAGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCAGCGCCATTTGTTCTGGTGTCGCCGTGTGCAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCGTCAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGTGCATTATCAAAGAAGAGATCCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTGCGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCAGCGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAG
12. YK-RSV-003 ORF AA, SEQ ID NO: 12
MELLILKANAITTILTAVTFCFASGQNITEEFYQSTCSAVSKGYLGALRTGWYTSVITIELSNIKENKCNGTDAKVKLIKQELDKYKNAVTDLQLLMQSTPATGSGSAICSGVAVCKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTFKVLDLKNYIDKQLLPIVNKQSCSIPNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMCIIKEEILAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSRTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYCVNKQEGQSLYVKGEPIINFYDPLVFPSSEFDASISQVNEKINQSLAFIRKSDELLHNVNAGKSTTNIMITTIIIVIIVILLSLIAVGLLLY
13 YK-RSV-003 mRNA, SEQ ID NO: 13
AGCGGCUCGGCCAUUUUGUCCCAGUCAGUCCGGAGGCUGCGGCUGCAGAAGUACCGCCUGCGGAGUAACUGCAAAGGCCACCAUGGAACUGCUGAUCCUGAAGGCCAACGCCAUCACCACCAUCCUGACCGCCGUGACCUUCUGUUUUGCCAGCGGCCAGAACAUCACCGAGGAAUUCUACCAGAGCACCUGUAGCGCCGUGUCCAAGGGAUAUCUGGGCGCCCUUAGAACCGGCUGGUACACCAGCGUGAUCACCAUCGAGCUGAGCAACAUCAAAGAAAACAAGUGCAACGGCACCGACGCCAAAGUGAAGCUGAUCAAGCAAGAGCUGGACAAGUACAAGAAUGCCGUGACCGACCUGCAGCUGCUGAUGCAGUCUACACCAGCCACAGGCUCUGGCAGCGCCAUUUGUUCUGGUGUCGCCGUGUGCAAAGUGCUGCACCUGGAAGGCGAAGUGAACAAGAUCAAGAGCGCCCUGCUGAGCACCAACAAGGCCGUGGUGUCUCUGAGCAAUGGCGUGUCCGUGCUGACCUUCAAGGUGCUGGACCUGAAGAACUACAUCGACAAACAGCUGCUGCCCAUCGUCAACAAGCAGUCCUGCAGCAUCCCCAACAUCGAGACAGUGAUCGAGUUCCAGCAGAAGAACAACCGGCUGCUGGAAAUCACCCGCGAGUUCUCUGUGAAUGCCGGCGUGACCACACCUGUGUCCACCUACAUGCUGACCAACAGCGAGCUGCUGAGCCUGAUCAACGACAUGCCCAUCACCAACGACCAGAAAAAGCUGAUGAGCAACAACGUGCAGAUCGUGCGGCAGCAGAGCUACAGCAUCAUGUGCAUUAUCAAAGAAGAGAUCCUGGCCUACGUGGUGCAGCUGCCUCUGUAUGGCGUGAUCGAUACCCCUUGCUGGAAGCUGCACACAAGCCCUCUGUGCACCACCAACACCAAAGAGGGCAGCAACAUCUGCCUGACCAGAACCGACAGAGGCUGGUACUGCGAUAAUGCCGGCAGCGUCUCAUUCUUCCCACAAGCCGAGACAUGCAAGGUGCAGAGCAACCGGGUGUUCUGCGACACCAUGAAUAGCAGAACCCUGCCUUCCGAAGUGAAUCUGUGCAACGUGGACAUCUUCAACCCUAAGUACGACUGCAAGAUCAUGACCAGCAAGACCGACGUGUCCAGCAGUGUGAUCACCUCACUGGGCGCCAUCGUGUCCUGUUACGGCAAGACCAAGUGCACCGCCAGCAACAAGAACCGGGGCAUCAUCAAGACCUUCAGCAACGGCUGCGACUACGUGUCCAACAAAGGCGUGGACACCGUGUCUGUGGGCAACACCCUGUACUGCGUGAACAAACAAGAGGGCCAGUCUCUGUACGUGAAGGGCGAGCCCAUCAUCAACUUCUACGACCCUCUGGUGUUCCCCAGCAGCGAGUUCGAUGCCAGCAUCAGCCAAGUGAACGAGAAGAUCAAUCAGAGCCUGGCCUUCAUCAGAAAGUCCGAUGAGCUGCUGCACAACGUGAACGCCGGCAAGUCCACCACCAAUAUCAUGAUCACGACCAUCAUCAUCGUGAUUAUCGUGAUCCUGCUGUCCCUGAUCGCCGUGGGCCUGCUGCUUUAUUGAUAAUAGGCUGGAGCCUCGGUGGCCAUGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCUUCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
14. YK-RSV-004 DNA, SEQ ID NO: 14
AGCGGCTCGGCCATTTTGTCCCAGTCAGTCCGGAGGCTGCGGCTGCAGAAGTACCGCCTGCGGAGTAACTGCAAAGGCCACCATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCAGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCAGCGCCATTTGTTCTGGTGTCGCCGTGTGCAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCATCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCGTCAACAAGCAGTCCTGCCCCATCAGCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGTGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTGCGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCAGCGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAGGCTGGAGCCTCGGTGGCCATGCTTCTTGCCCCTTGGGCCTCCCCCCAGCCCCTCCTCCCCTTCCTGCACCCGTACCCCCGTGGTCTTTGAATAAAGTCTGAGTGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
15. YK-RSV-004 ORF NT, SEQ ID NO: 15
ATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCAGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCAGCGCCATTTGTTCTGGTGTCGCCGTGTGCAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCATCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCGTCAACAAGCAGTCCTGCCCCATCAGCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGTGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTGCGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCAGCGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAG
16. YK-RSV-004 ORF AA, SEQ ID NO: 16
MELLILKANAITTILTAVTFCFASGQNITEEFYQSTCSAVSKGYLGALRTGWYTSVITIELSNIKENKCNGTDAKVKLIKQELDKYKNAVTDLQLLMQSTPATGSGSAICSGVAVCKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTIKVLDLKNYIDKQLLPIVNKQSCPISNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMCIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSRTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYCVNKQEGQSLYVKGEPIINFYDPLVFPSSEFDASISQVNEKINQSLAFIRKSDELLHNVNAGKSTTNIMITTIIIVIIVILLSLIAVGLLLY
17. YK-RSV-004 mRNA, SEQ ID NO: 17
AGCGGCUCGGCCAUUUUGUCCCAGUCAGUCCGGAGGCUGCGGCUGCAGAAGUACCGCCUGCGGAGUAACUGCAAAGGCCACCAUGGAACUGCUGAUCCUGAAGGCCAACGCCAUCACCACCAUCCUGACCGCCGUGACCUUCUGUUUUGCCAGCGGCCAGAACAUCACCGAGGAAUUCUACCAGAGCACCUGUAGCGCCGUGUCCAAGGGAUAUCUGGGCGCCCUUAGAACCGGCUGGUACACCAGCGUGAUCACCAUCGAGCUGAGCAACAUCAAAGAAAACAAGUGCAACGGCACCGACGCCAAAGUGAAGCUGAUCAAGCAAGAGCUGGACAAGUACAAGAAUGCCGUGACCGACCUGCAGCUGCUGAUGCAGUCUACACCAGCCACAGGCUCUGGCAGCGCCAUUUGUUCUGGUGUCGCCGUGUGCAAAGUGCUGCACCUGGAAGGCGAAGUGAACAAGAUCAAGAGCGCCCUGCUGAGCACCAACAAGGCCGUGGUGUCUCUGAGCAAUGGCGUGUCCGUGCUGACCAUCAAGGUGCUGGACCUGAAGAACUACAUCGACAAACAGCUGCUGCCCAUCGUCAACAAGCAGUCCUGCCCCAUCAGCAACAUCGAGACAGUGAUCGAGUUCCAGCAGAAGAACAACCGGCUGCUGGAAAUCACCCGCGAGUUCUCUGUGAAUGCCGGCGUGACCACACCUGUGUCCACCUACAUGCUGACCAACAGCGAGCUGCUGAGCCUGAUCAACGACAUGCCCAUCACCAACGACCAGAAAAAGCUGAUGAGCAACAACGUGCAGAUCGUGCGGCAGCAGAGCUACAGCAUCAUGUGCAUUAUCAAAGAAGAGGUGCUGGCCUACGUGGUGCAGCUGCCUCUGUAUGGCGUGAUCGAUACCCCUUGCUGGAAGCUGCACACAAGCCCUCUGUGCACCACCAACACCAAAGAGGGCAGCAACAUCUGCCUGACCAGAACCGACAGAGGCUGGUACUGCGAUAAUGCCGGCAGCGUCUCAUUCUUCCCACAAGCCGAGACAUGCAAGGUGCAGAGCAACCGGGUGUUCUGCGACACCAUGAAUAGCAGAACCCUGCCUUCCGAAGUGAAUCUGUGCAACGUGGACAUCUUCAACCCUAAGUACGACUGCAAGAUCAUGACCAGCAAGACCGACGUGUCCAGCAGUGUGAUCACCUCACUGGGCGCCAUCGUGUCCUGUUACGGCAAGACCAAGUGCACCGCCAGCAACAAGAACCGGGGCAUCAUCAAGACCUUCAGCAACGGCUGCGACUACGUGUCCAACAAAGGCGUGGACACCGUGUCUGUGGGCAACACCCUGUACUGCGUGAACAAACAAGAGGGCCAGUCUCUGUACGUGAAGGGCGAGCCCAUCAUCAACUUCUACGACCCUCUGGUGUUCCCCAGCAGCGAGUUCGAUGCCAGCAUCAGCCAAGUGAACGAGAAGAUCAAUCAGAGCCUGGCCUUCAUCAGAAAGUCCGAUGAGCUGCUGCACAACGUGAACGCCGGCAAGUCCACCACCAAUAUCAUGAUCACGACCAUCAUCAUCGUGAUUAUCGUGAUCCUGCUGUCCCUGAUCGCCGUGGGCCUGCUGCUUUAUUGAUAAUAGGCUGGAGCCUCGGUGGCCAUGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCUUCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
18. YK-RSV-005 DNA, SEQ ID NO: 18
AGCGGCTCGGCCATTTTGTCCCAGTCAGTCCGGAGGCTGCGGCTGCAGAAGTACCGCCTGCGGAGTAACTGCAAAGGCCACCATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCAGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCAGCGCCATTTGTTCTGGTGTCGCCGTGTGCAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCATCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCGTCAACAAGCAGTCCTGCAGCATCAGCCCCATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGTGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTGCGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCAGCGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAGGCTGGAGCCTCGGTGGCCATGCTTCTTGCCCCTTGGGCCTCCCCCCAGCCCCTCCTCCCCTTCCTGCACCCGTACCCCCGTGGTCTTTGAATAAAGTCTGAGTGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
19. YK-RSV-005 ORF NT, SEQ ID NO: 19
ATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCAGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCAGCGCCATTTGTTCTGGTGTCGCCGTGTGCAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCATCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCGTCAACAAGCAGTCCTGCAGCATCAGCCCCATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGTGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTGCGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCAGCGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAG
20. YK-RSV-005 ORF AA, SEQ ID NO: 20
MELLILKANAITTILTAVTFCFASGQNITEEFYQSTCSAVSKGYLGALRTGWYTSVITIELSNIKENKCNGTDAKVKLIKQELDKYKNAVTDLQLLMQSTPATGSGSAICSGVAVCKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTIKVLDLKNYIDKQLLPIVNKQSCSISPIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMCIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSRTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYCVNKQEGQSLYVKGEPIINFYDPLVFPSSEFDASISQVNEKINQSLAFIRKSDELLHNVNAGKSTTNIMITTIIIVIIVILLSLIAVGLLLY
21. YK-RSV-005 mRNA, SEQ ID NO: 21
AGCGGCUCGGCCAUUUUGUCCCAGUCAGUCCGGAGGCUGCGGCUGCAGAAGUACCGCCUGCGGAGUAACUGCAAAGGCCACCAUGGAACUGCUGAUCCUGAAGGCCAACGCCAUCACCACCAUCCUGACCGCCGUGACCUUCUGUUUUGCCAGCGGCCAGAACAUCACCGAGGAAUUCUACCAGAGCACCUGUAGCGCCGUGUCCAAGGGAUAUCUGGGCGCCCUUAGAACCGGCUGGUACACCAGCGUGAUCACCAUCGAGCUGAGCAACAUCAAAGAAAACAAGUGCAACGGCACCGACGCCAAAGUGAAGCUGAUCAAGCAAGAGCUGGACAAGUACAAGAAUGCCGUGACCGACCUGCAGCUGCUGAUGCAGUCUACACCAGCCACAGGCUCUGGCAGCGCCAUUUGUUCUGGUGUCGCCGUGUGCAAAGUGCUGCACCUGGAAGGCGAAGUGAACAAGAUCAAGAGCGCCCUGCUGAGCACCAACAAGGCCGUGGUGUCUCUGAGCAAUGGCGUGUCCGUGCUGACCAUCAAGGUGCUGGACCUGAAGAACUACAUCGACAAACAGCUGCUGCCCAUCGUCAACAAGCAGUCCUGCAGCAUCAGCCCCAUCGAGACAGUGAUCGAGUUCCAGCAGAAGAACAACCGGCUGCUGGAAAUCACCCGCGAGUUCUCUGUGAAUGCCGGCGUGACCACACCUGUGUCCACCUACAUGCUGACCAACAGCGAGCUGCUGAGCCUGAUCAACGACAUGCCCAUCACCAACGACCAGAAAAAGCUGAUGAGCAACAACGUGCAGAUCGUGCGGCAGCAGAGCUACAGCAUCAUGUGCAUUAUCAAAGAAGAGGUGCUGGCCUACGUGGUGCAGCUGCCUCUGUAUGGCGUGAUCGAUACCCCUUGCUGGAAGCUGCACACAAGCCCUCUGUGCACCACCAACACCAAAGAGGGCAGCAACAUCUGCCUGACCAGAACCGACAGAGGCUGGUACUGCGAUAAUGCCGGCAGCGUCUCAUUCUUCCCACAAGCCGAGACAUGCAAGGUGCAGAGCAACCGGGUGUUCUGCGACACCAUGAAUAGCAGAACCCUGCCUUCCGAAGUGAAUCUGUGCAACGUGGACAUCUUCAACCCUAAGUACGACUGCAAGAUCAUGACCAGCAAGACCGACGUGUCCAGCAGUGUGAUCACCUCACUGGGCGCCAUCGUGUCCUGUUACGGCAAGACCAAGUGCACCGCCAGCAACAAGAACCGGGGCAUCAUCAAGACCUUCAGCAACGGCUGCGACUACGUGUCCAACAAAGGCGUGGACACCGUGUCUGUGGGCAACACCCUGUACUGCGUGAACAAACAAGAGGGCCAGUCUCUGUACGUGAAGGGCGAGCCCAUCAUCAACUUCUACGACCCUCUGGUGUUCCCCAGCAGCGAGUUCGAUGCCAGCAUCAGCCAAGUGAACGAGAAGAUCAAUCAGAGCCUGGCCUUCAUCAGAAAGUCCGAUGAGCUGCUGCACAACGUGAACGCCGGCAAGUCCACCACCAAUAUCAUGAUCACGACCAUCAUCAUCGUGAUUAUCGUGAUCCUGCUGUCCCUGAUCGCCGUGGGCCUGCUGCUUUAUUGAUAAUAGGCUGGAGCCUCGGUGGCCAUGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCUUCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
22. YK-RSV-008 DNA, SEQ ID NO: 22
AGCGGCTCGGCCATTTTGTCCCAGTCAGTCCGGAGGCTGCGGCTGCAGAAGTACCGCCTGCGGAGTAACTGCAAAGGCCACCATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCTGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCAGCGCCATTGCTTCTGGTGTCGCCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGTGCACCATCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCGTCAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGAGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTACGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCAGCGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAGGCTGGAGCCTCGGTGGCCATGCTTCTTGCCCCTTGGGCCTCCCCCCAGCCCCTCCTCCCCTTCCTGCACCCGTACCCCCGTGGTCTTTGAATAAAGTCTGAGTGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
23. YK-RSV-008 ORF NT, SEQ ID NO: 23
ATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCTGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCAGCGCCATTGCTTCTGGTGTCGCCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGTGCACCATCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCGTCAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGAGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTACGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCAGCGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAG
24. YK-RSV-008 ORF AA, SEQ ID NO: 24
MELLILKANAITTILTAVTFCFASGQNITEEFYQSTCSAVSKGYLGALRTGWYTCVITIELSNIKENKCNGTDAKVKLIKQELDKYKNAVTDLQLLMQSTPATGSGSAIASGVAVSKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVCTIKVLDLKNYIDKQLLPIVNKQSCSIPNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMSIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSRTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEGQSLYVKGEPIINFYDPLVFPSSEFDASISQVNEKINQSLAFIRKSDELLHNVNAGKSTTNIMITTIIIVIIVILLSLIAVGLLLY
25. YK-RSV-008 mRNA, SEQ ID NO: 25
AGCGGCUCGGCCAUUUUGUCCCAGUCAGUCCGGAGGCUGCGGCUGCAGAAGUACCGCCUGCGGAGUAACUGCAAAGGCCACCAUGGAACUGCUGAUCCUGAAGGCCAACGCCAUCACCACCAUCCUGACCGCCGUGACCUUCUGUUUUGCCAGCGGCCAGAACAUCACCGAGGAAUUCUACCAGAGCACCUGUAGCGCCGUGUCCAAGGGAUAUCUGGGCGCCCUUAGAACCGGCUGGUACACCUGCGUGAUCACCAUCGAGCUGAGCAACAUCAAAGAAAACAAGUGCAACGGCACCGACGCCAAAGUGAAGCUGAUCAAGCAAGAGCUGGACAAGUACAAGAAUGCCGUGACCGACCUGCAGCUGCUGAUGCAGUCUACACCAGCCACAGGCUCUGGCAGCGCCAUUGCUUCUGGUGUCGCCGUGUCUAAAGUGCUGCACCUGGAAGGCGAAGUGAACAAGAUCAAGAGCGCCCUGCUGAGCACCAACAAGGCCGUGGUGUCUCUGAGCAAUGGCGUGUCCGUGUGCACCAUCAAGGUGCUGGACCUGAAGAACUACAUCGACAAACAGCUGCUGCCCAUCGUCAACAAGCAGUCCUGCAGCAUCCCCAACAUCGAGACAGUGAUCGAGUUCCAGCAGAAGAACAACCGGCUGCUGGAAAUCACCCGCGAGUUCUCUGUGAAUGCCGGCGUGACCACACCUGUGUCCACCUACAUGCUGACCAACAGCGAGCUGCUGAGCCUGAUCAACGACAUGCCCAUCACCAACGACCAGAAAAAGCUGAUGAGCAACAACGUGCAGAUCGUGCGGCAGCAGAGCUACAGCAUCAUGAGCAUUAUCAAAGAAGAGGUGCUGGCCUACGUGGUGCAGCUGCCUCUGUAUGGCGUGAUCGAUACCCCUUGCUGGAAGCUGCACACAAGCCCUCUGUGCACCACCAACACCAAAGAGGGCAGCAACAUCUGCCUGACCAGAACCGACAGAGGCUGGUACUGCGAUAAUGCCGGCAGCGUCUCAUUCUUCCCACAAGCCGAGACAUGCAAGGUGCAGAGCAACCGGGUGUUCUGCGACACCAUGAAUAGCAGAACCCUGCCUUCCGAAGUGAAUCUGUGCAACGUGGACAUCUUCAACCCUAAGUACGACUGCAAGAUCAUGACCAGCAAGACCGACGUGUCCAGCAGUGUGAUCACCUCACUGGGCGCCAUCGUGUCCUGUUACGGCAAGACCAAGUGCACCGCCAGCAACAAGAACCGGGGCAUCAUCAAGACCUUCAGCAACGGCUGCGACUACGUGUCCAACAAAGGCGUGGACACCGUGUCUGUGGGCAACACCCUGUACUACGUGAACAAACAAGAGGGCCAGUCUCUGUACGUGAAGGGCGAGCCCAUCAUCAACUUCUACGACCCUCUGGUGUUCCCCAGCAGCGAGUUCGAUGCCAGCAUCAGCCAAGUGAACGAGAAGAUCAAUCAGAGCCUGGCCUUCAUCAGAAAGUCCGAUGAGCUGCUGCACAACGUGAACGCCGGCAAGUCCACCACCAAUAUCAUGAUCACGACCAUCAUCAUCGUGAUUAUCGUGAUCCUGCUGUCCCUGAUCGCCGUGGGCCUGCUGCUUUAUUGAUAAUAGGCUGGAGCCUCGGUGGCCAUGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCUUCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
26. YK-RSV-009 DNA, SEQ ID NO: 26
AGCGGCTCGGCCATTTTGTCCCAGTCAGTCCGGAGGCTGCGGCTGCAGAAGTACCGCCTGCGGAGTAACTGCAAAGGCCACCATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACTGCAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCAGCGTGATCCTGATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCAGCGCCATTGCTTCTGGTGTCGCCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCGTCAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGAGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTACGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGTGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCAGCGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAGGCTGGAGCCTCGGTGGCCATGCTTCTTGCCCCTTGGGCCTCCCCCCAGCCCCTCCTCCCCTTCCTGCACCCGTACCCCCGTGGTCTTTGAATAAAGTCTGAGTGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
27. YK-RSV-009 ORF NT, SEQ ID NO: 27
ATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACTGCAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCAGCGTGATCCTGATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCAGCGCCATTGCTTCTGGTGTCGCCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCGTCAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGAGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTACGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGTGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCAGCGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAG
28. YK-RSV-009 ORF AA, SEQ ID NO: 28
MELLILKANAITTILTAVTFCFASGQNITEEFYCSTCSAVSKGYLGALRTGWYTSVILIELSNIKENKCNGTDAKVKLIKQELDKYKNAVTDLQLLMQSTPATGSGSAIASGVAVSKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTFKVLDLKNYIDKQLLPIVNKQSCSIPNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMSIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSRTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEGQSLYVKCEPIINFYDPLVFPSSEFDASISQVNEKINQSLAFIRKSDELLHNVNAGKSTTNIMITTIIIVIIVILLSLIAVGLLLY
29. YK-RSV-009 mRNA, SEQ ID NO: 29
AGCGGCUCGGCCAUUUUGUCCCAGUCAGUCCGGAGGCUGCGGCUGCAGAAGUACCGCCUGCGGAGUAACUGCAAAGGCCACCAUGGAACUGCUGAUCCUGAAGGCCAACGCCAUCACCACCAUCCUGACCGCCGUGACCUUCUGUUUUGCCAGCGGCCAGAACAUCACCGAGGAAUUCUACUGCAGCACCUGUAGCGCCGUGUCCAAGGGAUAUCUGGGCGCCCUUAGAACCGGCUGGUACACCAGCGUGAUCCUGAUCGAGCUGAGCAACAUCAAAGAAAACAAGUGCAACGGCACCGACGCCAAAGUGAAGCUGAUCAAGCAAGAGCUGGACAAGUACAAGAAUGCCGUGACCGACCUGCAGCUGCUGAUGCAGUCUACACCAGCCACAGGCUCUGGCAGCGCCAUUGCUUCUGGUGUCGCCGUGUCUAAAGUGCUGCACCUGGAAGGCGAAGUGAACAAGAUCAAGAGCGCCCUGCUGAGCACCAACAAGGCCGUGGUGUCUCUGAGCAAUGGCGUGUCCGUGCUGACCUUCAAGGUGCUGGACCUGAAGAACUACAUCGACAAACAGCUGCUGCCCAUCGUCAACAAGCAGUCCUGCAGCAUCCCCAACAUCGAGACAGUGAUCGAGUUCCAGCAGAAGAACAACCGGCUGCUGGAAAUCACCCGCGAGUUCUCUGUGAAUGCCGGCGUGACCACACCUGUGUCCACCUACAUGCUGACCAACAGCGAGCUGCUGAGCCUGAUCAACGACAUGCCCAUCACCAACGACCAGAAAAAGCUGAUGAGCAACAACGUGCAGAUCGUGCGGCAGCAGAGCUACAGCAUCAUGAGCAUUAUCAAAGAAGAGGUGCUGGCCUACGUGGUGCAGCUGCCUCUGUAUGGCGUGAUCGAUACCCCUUGCUGGAAGCUGCACACAAGCCCUCUGUGCACCACCAACACCAAAGAGGGCAGCAACAUCUGCCUGACCAGAACCGACAGAGGCUGGUACUGCGAUAAUGCCGGCAGCGUCUCAUUCUUCCCACAAGCCGAGACAUGCAAGGUGCAGAGCAACCGGGUGUUCUGCGACACCAUGAAUAGCAGAACCCUGCCUUCCGAAGUGAAUCUGUGCAACGUGGACAUCUUCAACCCUAAGUACGACUGCAAGAUCAUGACCAGCAAGACCGACGUGUCCAGCAGUGUGAUCACCUCACUGGGCGCCAUCGUGUCCUGUUACGGCAAGACCAAGUGCACCGCCAGCAACAAGAACCGGGGCAUCAUCAAGACCUUCAGCAACGGCUGCGACUACGUGUCCAACAAAGGCGUGGACACCGUGUCUGUGGGCAACACCCUGUACUACGUGAACAAACAAGAGGGCCAGUCUCUGUACGUGAAGUGCGAGCCCAUCAUCAACUUCUACGACCCUCUGGUGUUCCCCAGCAGCGAGUUCGAUGCCAGCAUCAGCCAAGUGAACGAGAAGAUCAAUCAGAGCCUGGCCUUCAUCAGAAAGUCCGAUGAGCUGCUGCACAACGUGAACGCCGGCAAGUCCACCACCAAUAUCAUGAUCACGACCAUCAUCAUCGUGAUUAUCGUGAUCCUGCUGUCCCUGAUCGCCGUGGGCCUGCUGCUUUAUUGAUAAUAGGCUGGAGCCUCGGUGGCCAUGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCUUCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
30. YK-RSV-010 DNA, SEQ ID NO: 30
AGCGGCTCGGCCATTTTGTCCCAGTCAGTCCGGAGGCTGCGGCTGCAGAAGTACCGCCTGCGGAGTAACTGCAAAGGCCACCATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCTGCGTGATCCTGATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCAGCGCCATTGCTTCTGGTGTCGCCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGTGCACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCGTCAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGAGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTACGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCAGCGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAGGCTGGAGCCTCGGTGGCCATGCTTCTTGCCCCTTGGGCCTCCCCCCAGCCCCTCCTCCCCTTCCTGCACCCGTACCCCCGTGGTCTTTGAATAAAGTCTGAGTGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
31. YK-RSV-010 ORF NT, SEQ ID NO: 31
ATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCTGCGTGATCCTGATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCAGCGCCATTGCTTCTGGTGTCGCCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGTGCACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCGTCAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGAGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTACGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCAGCGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAG
32. YK-RSV-010 ORF AA, SEQ ID NO: 32
MELLILKANAITTILTAVTFCFASGQNITEEFYQSTCSAVSKGYLGALRTGWYTCVILIELSNIKENKCNGTDAKVKLIKQELDKYKNAVTDLQLLMQSTPATGSGSAIASGVAVSKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVCTFKVLDLKNYIDKQLLPIVNKQSCSIPNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMSIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSRTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEGQSLYVKGEPIINFYDPLVFPSSEFDASISQVNEKINQSLAFIRKSDELLHNVNAGKSTTNIMITTIIIVIIVILLSLIAVGLLLY
33. YK-RSV-010 mRNA, SEQ ID NO: 33
AGCGGCUCGGCCAUUUUGUCCCAGUCAGUCCGGAGGCUGCGGCUGCAGAAGUACCGCCUGCGGAGUAACUGCAAAGGCCACCAUGGAACUGCUGAUCCUGAAGGCCAACGCCAUCACCACCAUCCUGACCGCCGUGACCUUCUGUUUUGCCAGCGGCCAGAACAUCACCGAGGAAUUCUACCAGAGCACCUGUAGCGCCGUGUCCAAGGGAUAUCUGGGCGCCCUUAGAACCGGCUGGUACACCUGCGUGAUCCUGAUCGAGCUGAGCAACAUCAAAGAAAACAAGUGCAACGGCACCGACGCCAAAGUGAAGCUGAUCAAGCAAGAGCUGGACAAGUACAAGAAUGCCGUGACCGACCUGCAGCUGCUGAUGCAGUCUACACCAGCCACAGGCUCUGGCAGCGCCAUUGCUUCUGGUGUCGCCGUGUCUAAAGUGCUGCACCUGGAAGGCGAAGUGAACAAGAUCAAGAGCGCCCUGCUGAGCACCAACAAGGCCGUGGUGUCUCUGAGCAAUGGCGUGUCCGUGUGCACCUUCAAGGUGCUGGACCUGAAGAACUACAUCGACAAACAGCUGCUGCCCAUCGUCAACAAGCAGUCCUGCAGCAUCCCCAACAUCGAGACAGUGAUCGAGUUCCAGCAGAAGAACAACCGGCUGCUGGAAAUCACCCGCGAGUUCUCUGUGAAUGCCGGCGUGACCACACCUGUGUCCACCUACAUGCUGACCAACAGCGAGCUGCUGAGCCUGAUCAACGACAUGCCCAUCACCAACGACCAGAAAAAGCUGAUGAGCAACAACGUGCAGAUCGUGCGGCAGCAGAGCUACAGCAUCAUGAGCAUUAUCAAAGAAGAGGUGCUGGCCUACGUGGUGCAGCUGCCUCUGUAUGGCGUGAUCGAUACCCCUUGCUGGAAGCUGCACACAAGCCCUCUGUGCACCACCAACACCAAAGAGGGCAGCAACAUCUGCCUGACCAGAACCGACAGAGGCUGGUACUGCGAUAAUGCCGGCAGCGUCUCAUUCUUCCCACAAGCCGAGACAUGCAAGGUGCAGAGCAACCGGGUGUUCUGCGACACCAUGAAUAGCAGAACCCUGCCUUCCGAAGUGAAUCUGUGCAACGUGGACAUCUUCAACCCUAAGUACGACUGCAAGAUCAUGACCAGCAAGACCGACGUGUCCAGCAGUGUGAUCACCUCACUGGGCGCCAUCGUGUCCUGUUACGGCAAGACCAAGUGCACCGCCAGCAACAAGAACCGGGGCAUCAUCAAGACCUUCAGCAACGGCUGCGACUACGUGUCCAACAAAGGCGUGGACACCGUGUCUGUGGGCAACACCCUGUACUACGUGAACAAACAAGAGGGCCAGUCUCUGUACGUGAAGGGCGAGCCCAUCAUCAACUUCUACGACCCUCUGGUGUUCCCCAGCAGCGAGUUCGAUGCCAGCAUCAGCCAAGUGAACGAGAAGAUCAAUCAGAGCCUGGCCUUCAUCAGAAAGUCCGAUGAGCUGCUGCACAACGUGAACGCCGGCAAGUCCACCACCAAUAUCAUGAUCACGACCAUCAUCAUCGUGAUUAUCGUGAUCCUGCUGUCCCUGAUCGCCGUGGGCCUGCUGCUUUAUUGAUAAUAGGCUGGAGCCUCGGUGGCCAUGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCUUCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
34. YK-RSV-011 DNA, SEQ ID NO: 34
AGCGGCTCGGCCATTTTGTCCCAGTCAGTCCGGAGGCTGCGGCTGCAGAAGTACCGCCTGCGGAGTAACTGCAAAGGCCACCATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACTGCAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCAGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCAGCGCCATTGCTTCTGGTGTCGCCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCGTCAACAAGCAGTCCTGCAGCATCCCCAACATCGAGATCGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGAGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTACGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGTGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCAGCGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAGGCTGGAGCCTCGGTGGCCATGCTTCTTGCCCCTTGGGCCTCCCCCCAGCCCCTCCTCCCCTTCCTGCACCCGTACCCCCGTGGTCTTTGAATAAAGTCTGAGTGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
35. YK-RSV-011 ORF NT, SEQ ID NO: 35
ATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACTGCAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCAGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCAGCGCCATTGCTTCTGGTGTCGCCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCGTCAACAAGCAGTCCTGCAGCATCCCCAACATCGAGATCGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGAGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTACGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGTGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCAGCGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAG
36. YK-RSV-011 ORF AA, SEQ ID NO: 36
MELLILKANAITTILTAVTFCFASGQNITEEFYCSTCSAVSKGYLGALRTGWYTSVITIELSNIKENKCNGTDAKVKLIKQELDKYKNAVTDLQLLMQSTPATGSGSAIASGVAVSKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTFKVLDLKNYIDKQLLPIVNKQSCSIPNIEIVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMSIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSRTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEGQSLYVKCEPIINFYDPLVFPSSEFDASISQVNEKINQSLAFIRKSDELLHNVNAGKSTTNIMITTIIIVIIVILLSLIAVGLLLY
37. YK-RSV-011 mRNA, SEQ ID NO: 37
AGCGGCUCGGCCAUUUUGUCCCAGUCAGUCCGGAGGCUGCGGCUGCAGAAGUACCGCCUGCGGAGUAACUGCAAAGGCCACCAUGGAACUGCUGAUCCUGAAGGCCAACGCCAUCACCACCAUCCUGACCGCCGUGACCUUCUGUUUUGCCAGCGGCCAGAACAUCACCGAGGAAUUCUACUGCAGCACCUGUAGCGCCGUGUCCAAGGGAUAUCUGGGCGCCCUUAGAACCGGCUGGUACACCAGCGUGAUCACCAUCGAGCUGAGCAACAUCAAAGAAAACAAGUGCAACGGCACCGACGCCAAAGUGAAGCUGAUCAAGCAAGAGCUGGACAAGUACAAGAAUGCCGUGACCGACCUGCAGCUGCUGAUGCAGUCUACACCAGCCACAGGCUCUGGCAGCGCCAUUGCUUCUGGUGUCGCCGUGUCUAAAGUGCUGCACCUGGAAGGCGAAGUGAACAAGAUCAAGAGCGCCCUGCUGAGCACCAACAAGGCCGUGGUGUCUCUGAGCAAUGGCGUGUCCGUGCUGACCUUCAAGGUGCUGGACCUGAAGAACUACAUCGACAAACAGCUGCUGCCCAUCGUCAACAAGCAGUCCUGCAGCAUCCCCAACAUCGAGAUCGUGAUCGAGUUCCAGCAGAAGAACAACCGGCUGCUGGAAAUCACCCGCGAGUUCUCUGUGAAUGCCGGCGUGACCACACCUGUGUCCACCUACAUGCUGACCAACAGCGAGCUGCUGAGCCUGAUCAACGACAUGCCCAUCACCAACGACCAGAAAAAGCUGAUGAGCAACAACGUGCAGAUCGUGCGGCAGCAGAGCUACAGCAUCAUGAGCAUUAUCAAAGAAGAGGUGCUGGCCUACGUGGUGCAGCUGCCUCUGUAUGGCGUGAUCGAUACCCCUUGCUGGAAGCUGCACACAAGCCCUCUGUGCACCACCAACACCAAAGAGGGCAGCAACAUCUGCCUGACCAGAACCGACAGAGGCUGGUACUGCGAUAAUGCCGGCAGCGUCUCAUUCUUCCCACAAGCCGAGACAUGCAAGGUGCAGAGCAACCGGGUGUUCUGCGACACCAUGAAUAGCAGAACCCUGCCUUCCGAAGUGAAUCUGUGCAACGUGGACAUCUUCAACCCUAAGUACGACUGCAAGAUCAUGACCAGCAAGACCGACGUGUCCAGCAGUGUGAUCACCUCACUGGGCGCCAUCGUGUCCUGUUACGGCAAGACCAAGUGCACCGCCAGCAACAAGAACCGGGGCAUCAUCAAGACCUUCAGCAACGGCUGCGACUACGUGUCCAACAAAGGCGUGGACACCGUGUCUGUGGGCAACACCCUGUACUACGUGAACAAACAAGAGGGCCAGUCUCUGUACGUGAAGUGCGAGCCCAUCAUCAACUUCUACGACCCUCUGGUGUUCCCCAGCAGCGAGUUCGAUGCCAGCAUCAGCCAAGUGAACGAGAAGAUCAAUCAGAGCCUGGCCUUCAUCAGAAAGUCCGAUGAGCUGCUGCACAACGUGAACGCCGGCAAGUCCACCACCAAUAUCAUGAUCACGACCAUCAUCAUCGUGAUUAUCGUGAUCCUGCUGUCCCUGAUCGCCGUGGGCCUGCUGCUUUAUUGAUAAUAGGCUGGAGCCUCGGUGGCCAUGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCUUCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
38. YK-RSV-012 DNA, SEQ ID NO: 38
AGCGGCTCGGCCATTTTGTCCCAGTCAGTCCGGAGGCTGCGGCTGCAGAAGTACCGCCTGCGGAGTAACTGCAAAGGCCACCATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCTGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCAGCGCCATTGCTTCTGGTGTCGCCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGTGCACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCGTCAACAAGCAGTCCTGCAGCATCCCCAACATCGAGATCGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGAGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTACGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCAGCGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAGGCTGGAGCCTCGGTGGCCATGCTTCTTGCCCCTTGGGCCTCCCCCCAGCCCCTCCTCCCCTTCCTGCACCCGTACCCCCGTGGTCTTTGAATAAAGTCTGAGTGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
39. YK-RSV-012 ORF NT, SEQ ID NO: 39
ATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCTGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCAGCGCCATTGCTTCTGGTGTCGCCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGTGCACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCGTCAACAAGCAGTCCTGCAGCATCCCCAACATCGAGATCGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGAGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTACGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCAGCGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAG
40. YK-RSV-012 ORF AA, SEQ ID NO: 40
MELLILKANAITTILTAVTFCFASGQNITEEFYQSTCSAVSKGYLGALRTGWYTCVITIELSNIKENKCNGTDAKVKLIKQELDKYKNAVTDLQLLMQSTPATGSGSAIASGVAVSKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVCTFKVLDLKNYIDKQLLPIVNKQSCSIPNIEIVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMSIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSRTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEGQSLYVKGEPIINFYDPLVFPSSEFDASISQVNEKINQSLAFIRKSDELLHNVNAGKSTTNIMITTIIIVIIVILLSLIAVGLLLY
41. YK-RSV-012 mRNA, SEQ ID NO: 41
AGCGGCUCGGCCAUUUUGUCCCAGUCAGUCCGGAGGCUGCGGCUGCAGAAGUACCGCCUGCGGAGUAACUGCAAAGGCCACCAUGGAACUGCUGAUCCUGAAGGCCAACGCCAUCACCACCAUCCUGACCGCCGUGACCUUCUGUUUUGCCAGCGGCCAGAACAUCACCGAGGAAUUCUACCAGAGCACCUGUAGCGCCGUGUCCAAGGGAUAUCUGGGCGCCCUUAGAACCGGCUGGUACACCUGCGUGAUCACCAUCGAGCUGAGCAACAUCAAAGAAAACAAGUGCAACGGCACCGACGCCAAAGUGAAGCUGAUCAAGCAAGAGCUGGACAAGUACAAGAAUGCCGUGACCGACCUGCAGCUGCUGAUGCAGUCUACACCAGCCACAGGCUCUGGCAGCGCCAUUGCUUCUGGUGUCGCCGUGUCUAAAGUGCUGCACCUGGAAGGCGAAGUGAACAAGAUCAAGAGCGCCCUGCUGAGCACCAACAAGGCCGUGGUGUCUCUGAGCAAUGGCGUGUCCGUGUGCACCUUCAAGGUGCUGGACCUGAAGAACUACAUCGACAAACAGCUGCUGCCCAUCGUCAACAAGCAGUCCUGCAGCAUCCCCAACAUCGAGAUCGUGAUCGAGUUCCAGCAGAAGAACAACCGGCUGCUGGAAAUCACCCGCGAGUUCUCUGUGAAUGCCGGCGUGACCACACCUGUGUCCACCUACAUGCUGACCAACAGCGAGCUGCUGAGCCUGAUCAACGACAUGCCCAUCACCAACGACCAGAAAAAGCUGAUGAGCAACAACGUGCAGAUCGUGCGGCAGCAGAGCUACAGCAUCAUGAGCAUUAUCAAAGAAGAGGUGCUGGCCUACGUGGUGCAGCUGCCUCUGUAUGGCGUGAUCGAUACCCCUUGCUGGAAGCUGCACACAAGCCCUCUGUGCACCACCAACACCAAAGAGGGCAGCAACAUCUGCCUGACCAGAACCGACAGAGGCUGGUACUGCGAUAAUGCCGGCAGCGUCUCAUUCUUCCCACAAGCCGAGACAUGCAAGGUGCAGAGCAACCGGGUGUUCUGCGACACCAUGAAUAGCAGAACCCUGCCUUCCGAAGUGAAUCUGUGCAACGUGGACAUCUUCAACCCUAAGUACGACUGCAAGAUCAUGACCAGCAAGACCGACGUGUCCAGCAGUGUGAUCACCUCACUGGGCGCCAUCGUGUCCUGUUACGGCAAGACCAAGUGCACCGCCAGCAACAAGAACCGGGGCAUCAUCAAGACCUUCAGCAACGGCUGCGACUACGUGUCCAACAAAGGCGUGGACACCGUGUCUGUGGGCAACACCCUGUACUACGUGAACAAACAAGAGGGCCAGUCUCUGUACGUGAAGGGCGAGCCCAUCAUCAACUUCUACGACCCUCUGGUGUUCCCCAGCAGCGAGUUCGAUGCCAGCAUCAGCCAAGUGAACGAGAAGAUCAAUCAGAGCCUGGCCUUCAUCAGAAAGUCCGAUGAGCUGCUGCACAACGUGAACGCCGGCAAGUCCACCACCAAUAUCAUGAUCACGACCAUCAUCAUCGUGAUUAUCGUGAUCCUGCUGUCCCUGAUCGCCGUGGGCCUGCUGCUUUAUUGAUAAUAGGCUGGAGCCUCGGUGGCCAUGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCUUCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
42. YK-RSV-013 DNA, SEQ ID NO: 42
AGCGGCTCGGCCATTTTGTCCCAGTCAGTCCGGAGGCTGCGGCTGCAGAAGTACCGCCTGCGGAGTAACTGCAAAGGCCACCATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCAGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCTGCGGCTCTGGCAGCGCCTGCGCTTCTGGTGTCGCCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCGTCAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGAGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTGCGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCAGCGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAGGCTGGAGCCTCGGTGGCCATGCTTCTTGCCCCTTGGGCCTCCCCCCAGCCCCTCCTCCCCTTCCTGCACCCGTACCCCCGTGGTCTTTGAATAAAGTCTGAGTGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
43. YK-RSV-013 ORF NT, SEQ ID NO: 43
ATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCAGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCTGCGGCTCTGGCAGCGCCTGCGCTTCTGGTGTCGCCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCGTCAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGAGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTGCGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCAGCGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAG
44. YK-RSV-013 ORF AA, SEQ ID NO: 44
MELLILKANAITTILTAVTFCFASGQNITEEFYQSTCSAVSKGYLGALRTGWYTSVITIELSNIKENKCNGTDAKVKLIKQELDKYKNAVTDLQLLMQSTPACGSGSACASGVAVSKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTFKVLDLKNYIDKQLLPIVNKQSCSIPNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMSIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSRTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYCVNKQEGQSLYVKGEPIINFYDPLVFPSSEFDASISQVNEKINQSLAFIRKSDELLHNVNAGKSTTNIMITTIIIVIIVILLSLIAVGLLLY
45. YK-RSV-013 mRNA, SEQ ID NO: 45
AGCGGCUCGGCCAUUUUGUCCCAGUCAGUCCGGAGGCUGCGGCUGCAGAAGUACCGCCUGCGGAGUAACUGCAAAGGCCACCAUGGAACUGCUGAUCCUGAAGGCCAACGCCAUCACCACCAUCCUGACCGCCGUGACCUUCUGUUUUGCCAGCGGCCAGAACAUCACCGAGGAAUUCUACCAGAGCACCUGUAGCGCCGUGUCCAAGGGAUAUCUGGGCGCCCUUAGAACCGGCUGGUACACCAGCGUGAUCACCAUCGAGCUGAGCAACAUCAAAGAAAACAAGUGCAACGGCACCGACGCCAAAGUGAAGCUGAUCAAGCAAGAGCUGGACAAGUACAAGAAUGCCGUGACCGACCUGCAGCUGCUGAUGCAGUCUACACCAGCCUGCGGCUCUGGCAGCGCCUGCGCUUCUGGUGUCGCCGUGUCUAAAGUGCUGCACCUGGAAGGCGAAGUGAACAAGAUCAAGAGCGCCCUGCUGAGCACCAACAAGGCCGUGGUGUCUCUGAGCAAUGGCGUGUCCGUGCUGACCUUCAAGGUGCUGGACCUGAAGAACUACAUCGACAAACAGCUGCUGCCCAUCGUCAACAAGCAGUCCUGCAGCAUCCCCAACAUCGAGACAGUGAUCGAGUUCCAGCAGAAGAACAACCGGCUGCUGGAAAUCACCCGCGAGUUCUCUGUGAAUGCCGGCGUGACCACACCUGUGUCCACCUACAUGCUGACCAACAGCGAGCUGCUGAGCCUGAUCAACGACAUGCCCAUCACCAACGACCAGAAAAAGCUGAUGAGCAACAACGUGCAGAUCGUGCGGCAGCAGAGCUACAGCAUCAUGAGCAUUAUCAAAGAAGAGGUGCUGGCCUACGUGGUGCAGCUGCCUCUGUAUGGCGUGAUCGAUACCCCUUGCUGGAAGCUGCACACAAGCCCUCUGUGCACCACCAACACCAAAGAGGGCAGCAACAUCUGCCUGACCAGAACCGACAGAGGCUGGUACUGCGAUAAUGCCGGCAGCGUCUCAUUCUUCCCACAAGCCGAGACAUGCAAGGUGCAGAGCAACCGGGUGUUCUGCGACACCAUGAAUAGCAGAACCCUGCCUUCCGAAGUGAAUCUGUGCAACGUGGACAUCUUCAACCCUAAGUACGACUGCAAGAUCAUGACCAGCAAGACCGACGUGUCCAGCAGUGUGAUCACCUCACUGGGCGCCAUCGUGUCCUGUUACGGCAAGACCAAGUGCACCGCCAGCAACAAGAACCGGGGCAUCAUCAAGACCUUCAGCAACGGCUGCGACUACGUGUCCAACAAAGGCGUGGACACCGUGUCUGUGGGCAACACCCUGUACUGCGUGAACAAACAAGAGGGCCAGUCUCUGUACGUGAAGGGCGAGCCCAUCAUCAACUUCUACGACCCUCUGGUGUUCCCCAGCAGCGAGUUCGAUGCCAGCAUCAGCCAAGUGAACGAGAAGAUCAAUCAGAGCCUGGCCUUCAUCAGAAAGUCCGAUGAGCUGCUGCACAACGUGAACGCCGGCAAGUCCACCACCAAUAUCAUGAUCACGACCAUCAUCAUCGUGAUUAUCGUGAUCCUGCUGUCCCUGAUCGCCGUGGGCCUGCUGCUUUAUUGAUAAUAGGCUGGAGCCUCGGUGGCCAUGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCUUCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
46. YK-RSV-014 DNA, SEQ ID NO: 46
AGCGGCTCGGCCATTTTGTCCCAGTCAGTCCGGAGGCTGCGGCTGCAGAAGTACCGCCTGCGGAGTAACTGCAAAGGCCACCATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACTGCAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCAGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCAGCGCCATTTGTTCTGGTGTCGCCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCATCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCGTCAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGAGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTGCGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGTGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCAGCGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAGGCTGGAGCCTCGGTGGCCATGCTTCTTGCCCCTTGGGCCTCCCCCCAGCCCCTCCTCCCCTTCCTGCACCCGTACCCCCGTGGTCTTTGAATAAAGTCTGAGTGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
47. YK-RSV-014 ORF NT, SEQ ID NO: 47
ATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACTGCAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCAGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCAGCGCCATTTGTTCTGGTGTCGCCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCATCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCGTCAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGAGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTGCGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGTGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCAGCGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAG
48. YK-RSV-014 ORF AA, SEQ ID NO: 48
MELLILKANAITTILTAVTFCFASGQNITEEFYCSTCSAVSKGYLGALRTGWYTSVITIELSNIKENKCNGTDAKVKLIKQELDKYKNAVTDLQLLMQSTPATGSGSAICSGVAVSKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTIKVLDLKNYIDKQLLPIVNKQSCSIPNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMSIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSRTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYCVNKQEGQSLYVKCEPIINFYDPLVFPSSEFDASISQVNEKINQSLAFIRKSDELLHNVNAGKSTTNIMITTIIIVIIVILLSLIAVGLLLY
49. YK-RSV-014 mRNA, SEQ ID NO: 49
AGCGGCUCGGCCAUUUUGUCCCAGUCAGUCCGGAGGCUGCGGCUGCAGAAGUACCGCCUGCGGAGUAACUGCAAAGGCCACCAUGGAACUGCUGAUCCUGAAGGCCAACGCCAUCACCACCAUCCUGACCGCCGUGACCUUCUGUUUUGCCAGCGGCCAGAACAUCACCGAGGAAUUCUACUGCAGCACCUGUAGCGCCGUGUCCAAGGGAUAUCUGGGCGCCCUUAGAACCGGCUGGUACACCAGCGUGAUCACCAUCGAGCUGAGCAACAUCAAAGAAAACAAGUGCAACGGCACCGACGCCAAAGUGAAGCUGAUCAAGCAAGAGCUGGACAAGUACAAGAAUGCCGUGACCGACCUGCAGCUGCUGAUGCAGUCUACACCAGCCACAGGCUCUGGCAGCGCCAUUUGUUCUGGUGUCGCCGUGUCUAAAGUGCUGCACCUGGAAGGCGAAGUGAACAAGAUCAAGAGCGCCCUGCUGAGCACCAACAAGGCCGUGGUGUCUCUGAGCAAUGGCGUGUCCGUGCUGACCAUCAAGGUGCUGGACCUGAAGAACUACAUCGACAAACAGCUGCUGCCCAUCGUCAACAAGCAGUCCUGCAGCAUCCCCAACAUCGAGACAGUGAUCGAGUUCCAGCAGAAGAACAACCGGCUGCUGGAAAUCACCCGCGAGUUCUCUGUGAAUGCCGGCGUGACCACACCUGUGUCCACCUACAUGCUGACCAACAGCGAGCUGCUGAGCCUGAUCAACGACAUGCCCAUCACCAACGACCAGAAAAAGCUGAUGAGCAACAACGUGCAGAUCGUGCGGCAGCAGAGCUACAGCAUCAUGAGCAUUAUCAAAGAAGAGGUGCUGGCCUACGUGGUGCAGCUGCCUCUGUAUGGCGUGAUCGAUACCCCUUGCUGGAAGCUGCACACAAGCCCUCUGUGCACCACCAACACCAAAGAGGGCAGCAACAUCUGCCUGACCAGAACCGACAGAGGCUGGUACUGCGAUAAUGCCGGCAGCGUCUCAUUCUUCCCACAAGCCGAGACAUGCAAGGUGCAGAGCAACCGGGUGUUCUGCGACACCAUGAAUAGCAGAACCCUGCCUUCCGAAGUGAAUCUGUGCAACGUGGACAUCUUCAACCCUAAGUACGACUGCAAGAUCAUGACCAGCAAGACCGACGUGUCCAGCAGUGUGAUCACCUCACUGGGCGCCAUCGUGUCCUGUUACGGCAAGACCAAGUGCACCGCCAGCAACAAGAACCGGGGCAUCAUCAAGACCUUCAGCAACGGCUGCGACUACGUGUCCAACAAAGGCGUGGACACCGUGUCUGUGGGCAACACCCUGUACUGCGUGAACAAACAAGAGGGCCAGUCUCUGUACGUGAAGUGCGAGCCCAUCAUCAACUUCUACGACCCUCUGGUGUUCCCCAGCAGCGAGUUCGAUGCCAGCAUCAGCCAAGUGAACGAGAAGAUCAAUCAGAGCCUGGCCUUCAUCAGAAAGUCCGAUGAGCUGCUGCACAACGUGAACGCCGGCAAGUCCACCACCAAUAUCAUGAUCACGACCAUCAUCAUCGUGAUUAUCGUGAUCCUGCUGUCCCUGAUCGCCGUGGGCCUGCUGCUUUAUUGAUAAUAGGCUGGAGCCUCGGUGGCCAUGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCUUCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
50. YK-RSV-015 DNA, SEQ ID NO: 50
AGCGGCTCGGCCATTTTGTCCCAGTCAGTCCGGAGGCTGCGGCTGCAGAAGTACCGCCTGCGGAGTAACTGCAAAGGCCACCATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCTGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCAGCGCCATTTGTTCTGGTGTCGCCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGTGCACCATCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCGTCAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGAGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTGCGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCAGCGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAGGCTGGAGCCTCGGTGGCCATGCTTCTTGCCCCTTGGGCCTCCCCCCAGCCCCTCCTCCCCTTCCTGCACCCGTACCCCCGTGGTCTTTGAATAAAGTCTGAGTGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
51. YK-RSV-015 ORF NT, SEQ ID NO: 51
ATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCTGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCAGCGCCATTTGTTCTGGTGTCGCCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGTGCACCATCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCGTCAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGAGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTGCGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCAGCGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAG
52. YK-RSV-015 ORF AA, SEQ ID NO: 52
MELLILKANAITTILTAVTFCFASGQNITEEFYQSTCSAVSKGYLGALRTGWYTCVITIELSNIKENKCNGTDAKVKLIKQELDKYKNAVTDLQLLMQSTPATGSGSAICSGVAVSKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVCTIKVLDLKNYIDKQLLPIVNKQSCSIPNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMSIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSRTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYCVNKQEGQSLYVKGEPIINFYDPLVFPSSEFDASISQVNEKINQSLAFIRKSDELLHNVNAGKSTTNIMITTIIIVIIVILLSLIAVGLLLY
53. YK-RSV-015 mRNA, SEQ ID NO: 53
AGCGGCUCGGCCAUUUUGUCCCAGUCAGUCCGGAGGCUGCGGCUGCAGAAGUACCGCCUGCGGAGUAACUGCAAAGGCCACCAUGGAACUGCUGAUCCUGAAGGCCAACGCCAUCACCACCAUCCUGACCGCCGUGACCUUCUGUUUUGCCAGCGGCCAGAACAUCACCGAGGAAUUCUACCAGAGCACCUGUAGCGCCGUGUCCAAGGGAUAUCUGGGCGCCCUUAGAACCGGCUGGUACACCUGCGUGAUCACCAUCGAGCUGAGCAACAUCAAAGAAAACAAGUGCAACGGCACCGACGCCAAAGUGAAGCUGAUCAAGCAAGAGCUGGACAAGUACAAGAAUGCCGUGACCGACCUGCAGCUGCUGAUGCAGUCUACACCAGCCACAGGCUCUGGCAGCGCCAUUUGUUCUGGUGUCGCCGUGUCUAAAGUGCUGCACCUGGAAGGCGAAGUGAACAAGAUCAAGAGCGCCCUGCUGAGCACCAACAAGGCCGUGGUGUCUCUGAGCAAUGGCGUGUCCGUGUGCACCAUCAAGGUGCUGGACCUGAAGAACUACAUCGACAAACAGCUGCUGCCCAUCGUCAACAAGCAGUCCUGCAGCAUCCCCAACAUCGAGACAGUGAUCGAGUUCCAGCAGAAGAACAACCGGCUGCUGGAAAUCACCCGCGAGUUCUCUGUGAAUGCCGGCGUGACCACACCUGUGUCCACCUACAUGCUGACCAACAGCGAGCUGCUGAGCCUGAUCAACGACAUGCCCAUCACCAACGACCAGAAAAAGCUGAUGAGCAACAACGUGCAGAUCGUGCGGCAGCAGAGCUACAGCAUCAUGAGCAUUAUCAAAGAAGAGGUGCUGGCCUACGUGGUGCAGCUGCCUCUGUAUGGCGUGAUCGAUACCCCUUGCUGGAAGCUGCACACAAGCCCUCUGUGCACCACCAACACCAAAGAGGGCAGCAACAUCUGCCUGACCAGAACCGACAGAGGCUGGUACUGCGAUAAUGCCGGCAGCGUCUCAUUCUUCCCACAAGCCGAGACAUGCAAGGUGCAGAGCAACCGGGUGUUCUGCGACACCAUGAAUAGCAGAACCCUGCCUUCCGAAGUGAAUCUGUGCAACGUGGACAUCUUCAACCCUAAGUACGACUGCAAGAUCAUGACCAGCAAGACCGACGUGUCCAGCAGUGUGAUCACCUCACUGGGCGCCAUCGUGUCCUGUUACGGCAAGACCAAGUGCACCGCCAGCAACAAGAACCGGGGCAUCAUCAAGACCUUCAGCAACGGCUGCGACUACGUGUCCAACAAAGGCGUGGACACCGUGUCUGUGGGCAACACCCUGUACUGCGUGAACAAACAAGAGGGCCAGUCUCUGUACGUGAAGGGCGAGCCCAUCAUCAACUUCUACGACCCUCUGGUGUUCCCCAGCAGCGAGUUCGAUGCCAGCAUCAGCCAAGUGAACGAGAAGAUCAAUCAGAGCCUGGCCUUCAUCAGAAAGUCCGAUGAGCUGCUGCACAACGUGAACGCCGGCAAGUCCACCACCAAUAUCAUGAUCACGACCAUCAUCAUCGUGAUUAUCGUGAUCCUGCUGUCCCUGAUCGCCGUGGGCCUGCUGCUUUAUUGAUAAUAGGCUGGAGCCUCGGUGGCCAUGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCUUCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
54. YK-RSV-016 DNA, SEQ ID NO: 54
AGCGGCTCGGCCATTTTGTCCCAGTCAGTCCGGAGGCTGCGGCTGCAGAAGTACCGCCTGCGGAGTAACTGCAAAGGCCACCATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACTGCAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCAGCGTGATCCTGATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCAGCGCCATTTGTTCTGGTGTCGCCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCGTCAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGAGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTGCGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGTGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCAGCGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAGGCTGGAGCCTCGGTGGCCATGCTTCTTGCCCCTTGGGCCTCCCCCCAGCCCCTCCTCCCCTTCCTGCACCCGTACCCCCGTGGTCTTTGAATAAAGTCTGAGTGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
55. YK-RSV-016 ORF NT, SEQ ID NO: 55
ATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACTGCAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCAGCGTGATCCTGATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCAGCGCCATTTGTTCTGGTGTCGCCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCGTCAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGAGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTGCGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGTGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCAGCGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAG
56. YK-RSV-016 ORF AA, SEQ ID NO: 56
MELLILKANAITTILTAVTFCFASGQNITEEFYCSTCSAVSKGYLGALRTGWYTSVILIELSNIKENKCNGTDAKVKLIKQELDKYKNAVTDLQLLMQSTPATGSGSAICSGVAVSKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTFKVLDLKNYIDKQLLPIVNKQSCSIPNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMSIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSRTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYCVNKQEGQSLYVKCEPIINFYDPLVFPSSEFDASISQVNEKINQSLAFIRKSDELLHNVNAGKSTTNIMITTIIIVIIVILLSLIAVGLLLY
57. YK-RSV-016 mRNA, SEQ ID NO: 57
AGCGGCUCGGCCAUUUUGUCCCAGUCAGUCCGGAGGCUGCGGCUGCAGAAGUACCGCCUGCGGAGUAACUGCAAAGGCCACCAUGGAACUGCUGAUCCUGAAGGCCAACGCCAUCACCACCAUCCUGACCGCCGUGACCUUCUGUUUUGCCAGCGGCCAGAACAUCACCGAGGAAUUCUACUGCAGCACCUGUAGCGCCGUGUCCAAGGGAUAUCUGGGCGCCCUUAGAACCGGCUGGUACACCAGCGUGAUCCUGAUCGAGCUGAGCAACAUCAAAGAAAACAAGUGCAACGGCACCGACGCCAAAGUGAAGCUGAUCAAGCAAGAGCUGGACAAGUACAAGAAUGCCGUGACCGACCUGCAGCUGCUGAUGCAGUCUACACCAGCCACAGGCUCUGGCAGCGCCAUUUGUUCUGGUGUCGCCGUGUCUAAAGUGCUGCACCUGGAAGGCGAAGUGAACAAGAUCAAGAGCGCCCUGCUGAGCACCAACAAGGCCGUGGUGUCUCUGAGCAAUGGCGUGUCCGUGCUGACCUUCAAGGUGCUGGACCUGAAGAACUACAUCGACAAACAGCUGCUGCCCAUCGUCAACAAGCAGUCCUGCAGCAUCCCCAACAUCGAGACAGUGAUCGAGUUCCAGCAGAAGAACAACCGGCUGCUGGAAAUCACCCGCGAGUUCUCUGUGAAUGCCGGCGUGACCACACCUGUGUCCACCUACAUGCUGACCAACAGCGAGCUGCUGAGCCUGAUCAACGACAUGCCCAUCACCAACGACCAGAAAAAGCUGAUGAGCAACAACGUGCAGAUCGUGCGGCAGCAGAGCUACAGCAUCAUGAGCAUUAUCAAAGAAGAGGUGCUGGCCUACGUGGUGCAGCUGCCUCUGUAUGGCGUGAUCGAUACCCCUUGCUGGAAGCUGCACACAAGCCCUCUGUGCACCACCAACACCAAAGAGGGCAGCAACAUCUGCCUGACCAGAACCGACAGAGGCUGGUACUGCGAUAAUGCCGGCAGCGUCUCAUUCUUCCCACAAGCCGAGACAUGCAAGGUGCAGAGCAACCGGGUGUUCUGCGACACCAUGAAUAGCAGAACCCUGCCUUCCGAAGUGAAUCUGUGCAACGUGGACAUCUUCAACCCUAAGUACGACUGCAAGAUCAUGACCAGCAAGACCGACGUGUCCAGCAGUGUGAUCACCUCACUGGGCGCCAUCGUGUCCUGUUACGGCAAGACCAAGUGCACCGCCAGCAACAAGAACCGGGGCAUCAUCAAGACCUUCAGCAACGGCUGCGACUACGUGUCCAACAAAGGCGUGGACACCGUGUCUGUGGGCAACACCCUGUACUGCGUGAACAAACAAGAGGGCCAGUCUCUGUACGUGAAGUGCGAGCCCAUCAUCAACUUCUACGACCCUCUGGUGUUCCCCAGCAGCGAGUUCGAUGCCAGCAUCAGCCAAGUGAACGAGAAGAUCAAUCAGAGCCUGGCCUUCAUCAGAAAGUCCGAUGAGCUGCUGCACAACGUGAACGCCGGCAAGUCCACCACCAAUAUCAUGAUCACGACCAUCAUCAUCGUGAUUAUCGUGAUCCUGCUGUCCCUGAUCGCCGUGGGCCUGCUGCUUUAUUGAUAAUAGGCUGGAGCCUCGGUGGCCAUGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCUUCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
58. YK-RSV-017 DNA, SEQ ID NO: 58
AGCGGCTCGGCCATTTTGTCCCAGTCAGTCCGGAGGCTGCGGCTGCAGAAGTACCGCCTGCGGAGTAACTGCAAAGGCCACCATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCTGCGTGATCCTGATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCAGCGCCATTTGTTCTGGTGTCGCCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGTGCACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCGTCAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGAGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTGCGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCAGCGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAGGCTGGAGCCTCGGTGGCCATGCTTCTTGCCCCTTGGGCCTCCCCCCAGCCCCTCCTCCCCTTCCTGCACCCGTACCCCCGTGGTCTTTGAATAAAGTCTGAGTGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
59. YK-RSV-017 ORF NT, SEQ ID NO: 59
ATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCTGCGTGATCCTGATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCAGCGCCATTTGTTCTGGTGTCGCCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGTGCACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCGTCAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGAGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTGCGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCAGCGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAG
60. YK-RSV-017 ORF AA, SEQ ID NO: 60
MELLILKANAITTILTAVTFCFASGQNITEEFYQSTCSAVSKGYLGALRTGWYTCVILIELSNIKENKCNGTDAKVKLIKQELDKYKNAVTDLQLLMQSTPATGSGSAICSGVAVSKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVCTFKVLDLKNYIDKQLLPIVNKQSCSIPNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMSIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSRTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYCVNKQEGQSLYVKGEPIINFYDPLVFPSSEFDASISQVNEKINQSLAFIRKSDELLHNVNAGKSTTNIMITTIIIVIIVILLSLIAVGLLLY
61. YK-RSV-017 mRNA, SEQ ID NO: 61
AGCGGCUCGGCCAUUUUGUCCCAGUCAGUCCGGAGGCUGCGGCUGCAGAAGUACCGCCUGCGGAGUAACUGCAAAGGCCACCAUGGAACUGCUGAUCCUGAAGGCCAACGCCAUCACCACCAUCCUGACCGCCGUGACCUUCUGUUUUGCCAGCGGCCAGAACAUCACCGAGGAAUUCUACCAGAGCACCUGUAGCGCCGUGUCCAAGGGAUAUCUGGGCGCCCUUAGAACCGGCUGGUACACCUGCGUGAUCCUGAUCGAGCUGAGCAACAUCAAAGAAAACAAGUGCAACGGCACCGACGCCAAAGUGAAGCUGAUCAAGCAAGAGCUGGACAAGUACAAGAAUGCCGUGACCGACCUGCAGCUGCUGAUGCAGUCUACACCAGCCACAGGCUCUGGCAGCGCCAUUUGUUCUGGUGUCGCCGUGUCUAAAGUGCUGCACCUGGAAGGCGAAGUGAACAAGAUCAAGAGCGCCCUGCUGAGCACCAACAAGGCCGUGGUGUCUCUGAGCAAUGGCGUGUCCGUGUGCACCUUCAAGGUGCUGGACCUGAAGAACUACAUCGACAAACAGCUGCUGCCCAUCGUCAACAAGCAGUCCUGCAGCAUCCCCAACAUCGAGACAGUGAUCGAGUUCCAGCAGAAGAACAACCGGCUGCUGGAAAUCACCCGCGAGUUCUCUGUGAAUGCCGGCGUGACCACACCUGUGUCCACCUACAUGCUGACCAACAGCGAGCUGCUGAGCCUGAUCAACGACAUGCCCAUCACCAACGACCAGAAAAAGCUGAUGAGCAACAACGUGCAGAUCGUGCGGCAGCAGAGCUACAGCAUCAUGAGCAUUAUCAAAGAAGAGGUGCUGGCCUACGUGGUGCAGCUGCCUCUGUAUGGCGUGAUCGAUACCCCUUGCUGGAAGCUGCACACAAGCCCUCUGUGCACCACCAACACCAAAGAGGGCAGCAACAUCUGCCUGACCAGAACCGACAGAGGCUGGUACUGCGAUAAUGCCGGCAGCGUCUCAUUCUUCCCACAAGCCGAGACAUGCAAGGUGCAGAGCAACCGGGUGUUCUGCGACACCAUGAAUAGCAGAACCCUGCCUUCCGAAGUGAAUCUGUGCAACGUGGACAUCUUCAACCCUAAGUACGACUGCAAGAUCAUGACCAGCAAGACCGACGUGUCCAGCAGUGUGAUCACCUCACUGGGCGCCAUCGUGUCCUGUUACGGCAAGACCAAGUGCACCGCCAGCAACAAGAACCGGGGCAUCAUCAAGACCUUCAGCAACGGCUGCGACUACGUGUCCAACAAAGGCGUGGACACCGUGUCUGUGGGCAACACCCUGUACUGCGUGAACAAACAAGAGGGCCAGUCUCUGUACGUGAAGGGCGAGCCCAUCAUCAACUUCUACGACCCUCUGGUGUUCCCCAGCAGCGAGUUCGAUGCCAGCAUCAGCCAAGUGAACGAGAAGAUCAAUCAGAGCCUGGCCUUCAUCAGAAAGUCCGAUGAGCUGCUGCACAACGUGAACGCCGGCAAGUCCACCACCAAUAUCAUGAUCACGACCAUCAUCAUCGUGAUUAUCGUGAUCCUGCUGUCCCUGAUCGCCGUGGGCCUGCUGCUUUAUUGAUAAUAGGCUGGAGCCUCGGUGGCCAUGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCUUCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
62. YK-RSV-018 DNA, SEQ ID NO: 62
AGCGGCTCGGCCATTTTGTCCCAGTCAGTCCGGAGGCTGCGGCTGCAGAAGTACCGCCTGCGGAGTAACTGCAAAGGCCACCATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACTGCAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCAGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCAGCGCCATTTGTTCTGGTGTCGCCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCGTCAACAAGCAGTCCTGCAGCATCCCCAACATCGAGATCGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGAGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTGCGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGTGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCAGCGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAGGCTGGAGCCTCGGTGGCCATGCTTCTTGCCCCTTGGGCCTCCCCCCAGCCCCTCCTCCCCTTCCTGCACCCGTACCCCCGTGGTCTTTGAATAAAGTCTGAGTGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
63. YK-RSV-018 ORF NT, SEQ ID NO: 63
ATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACTGCAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCAGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCAGCGCCATTTGTTCTGGTGTCGCCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCGTCAACAAGCAGTCCTGCAGCATCCCCAACATCGAGATCGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGAGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTGCGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGTGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCAGCGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAG
64. YK-RSV-018 ORF AA, SEQ ID NO: 64
MELLILKANAITTILTAVTFCFASGQNITEEFYCSTCSAVSKGYLGALRTGWYTSVITIELSNIKENKCNGTDAKVKLIKQELDKYKNAVTDLQLLMQSTPATGSGSAICSGVAVSKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTFKVLDLKNYIDKQLLPIVNKQSCSIPNIEIVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMSIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSRTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYCVNKQEGQSLYVKCEPIINFYDPLVFPSSEFDASISQVNEKINQSLAFIRKSDELLHNVNAGKSTTNIMITTIIIVIIVILLSLIAVGLLLY
65. YK-RSV-018 mRNA, SEQ ID NO: 65
AGCGGCUCGGCCAUUUUGUCCCAGUCAGUCCGGAGGCUGCGGCUGCAGAAGUACCGCCUGCGGAGUAACUGCAAAGGCCACCAUGGAACUGCUGAUCCUGAAGGCCAACGCCAUCACCACCAUCCUGACCGCCGUGACCUUCUGUUUUGCCAGCGGCCAGAACAUCACCGAGGAAUUCUACUGCAGCACCUGUAGCGCCGUGUCCAAGGGAUAUCUGGGCGCCCUUAGAACCGGCUGGUACACCAGCGUGAUCACCAUCGAGCUGAGCAACAUCAAAGAAAACAAGUGCAACGGCACCGACGCCAAAGUGAAGCUGAUCAAGCAAGAGCUGGACAAGUACAAGAAUGCCGUGACCGACCUGCAGCUGCUGAUGCAGUCUACACCAGCCACAGGCUCUGGCAGCGCCAUUUGUUCUGGUGUCGCCGUGUCUAAAGUGCUGCACCUGGAAGGCGAAGUGAACAAGAUCAAGAGCGCCCUGCUGAGCACCAACAAGGCCGUGGUGUCUCUGAGCAAUGGCGUGUCCGUGCUGACCUUCAAGGUGCUGGACCUGAAGAACUACAUCGACAAACAGCUGCUGCCCAUCGUCAACAAGCAGUCCUGCAGCAUCCCCAACAUCGAGAUCGUGAUCGAGUUCCAGCAGAAGAACAACCGGCUGCUGGAAAUCACCCGCGAGUUCUCUGUGAAUGCCGGCGUGACCACACCUGUGUCCACCUACAUGCUGACCAACAGCGAGCUGCUGAGCCUGAUCAACGACAUGCCCAUCACCAACGACCAGAAAAAGCUGAUGAGCAACAACGUGCAGAUCGUGCGGCAGCAGAGCUACAGCAUCAUGAGCAUUAUCAAAGAAGAGGUGCUGGCCUACGUGGUGCAGCUGCCUCUGUAUGGCGUGAUCGAUACCCCUUGCUGGAAGCUGCACACAAGCCCUCUGUGCACCACCAACACCAAAGAGGGCAGCAACAUCUGCCUGACCAGAACCGACAGAGGCUGGUACUGCGAUAAUGCCGGCAGCGUCUCAUUCUUCCCACAAGCCGAGACAUGCAAGGUGCAGAGCAACCGGGUGUUCUGCGACACCAUGAAUAGCAGAACCCUGCCUUCCGAAGUGAAUCUGUGCAACGUGGACAUCUUCAACCCUAAGUACGACUGCAAGAUCAUGACCAGCAAGACCGACGUGUCCAGCAGUGUGAUCACCUCACUGGGCGCCAUCGUGUCCUGUUACGGCAAGACCAAGUGCACCGCCAGCAACAAGAACCGGGGCAUCAUCAAGACCUUCAGCAACGGCUGCGACUACGUGUCCAACAAAGGCGUGGACACCGUGUCUGUGGGCAACACCCUGUACUGCGUGAACAAACAAGAGGGCCAGUCUCUGUACGUGAAGUGCGAGCCCAUCAUCAACUUCUACGACCCUCUGGUGUUCCCCAGCAGCGAGUUCGAUGCCAGCAUCAGCCAAGUGAACGAGAAGAUCAAUCAGAGCCUGGCCUUCAUCAGAAAGUCCGAUGAGCUGCUGCACAACGUGAACGCCGGCAAGUCCACCACCAAUAUCAUGAUCACGACCAUCAUCAUCGUGAUUAUCGUGAUCCUGCUGUCCCUGAUCGCCGUGGGCCUGCUGCUUUAUUGAUAAUAGGCUGGAGCCUCGGUGGCCAUGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCUUCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
66. YK-RSV-019 DNA, SEQ ID NO: 66
AGCGGCTCGGCCATTTTGTCCCAGTCAGTCCGGAGGCTGCGGCTGCAGAAGTACCGCCTGCGGAGTAACTGCAAAGGCCACCATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCTGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCAGCGCCATTTGTTCTGGTGTCGCCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGTGCACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCGTCAACAAGCAGTCCTGCAGCATCCCCAACATCGAGATCGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGAGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTGCGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCAGCGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAGGCTGGAGCCTCGGTGGCCATGCTTCTTGCCCCTTGGGCCTCCCCCCAGCCCCTCCTCCCCTTCCTGCACCCGTACCCCCGTGGTCTTTGAATAAAGTCTGAGTGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
67. YK-RSV-019 ORF NT, SEQ ID NO: 67
ATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCTGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCAGCGCCATTTGTTCTGGTGTCGCCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGTGCACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCGTCAACAAGCAGTCCTGCAGCATCCCCAACATCGAGATCGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGAGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTGCGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCAGCGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAG
68. YK-RSV-019 ORF AA, SEQ ID NO: 68
MELLILKANAITTILTAVTFCFASGQNITEEFYQSTCSAVSKGYLGALRTGWYTCVITIELSNIKENKCNGTDAKVKLIKQELDKYKNAVTDLQLLMQSTPATGSGSAICSGVAVSKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVCTFKVLDLKNYIDKQLLPIVNKQSCSIPNIEIVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMSIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSRTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYCVNKQEGQSLYVKGEPIINFYDPLVFPSSEFDASISQVNEKINQSLAFIRKSDELLHNVNAGKSTTNIMITTIIIVIIVILLSLIAVGLLLY
69. YK-RSV-019 mRNA, SEQ ID NO: 69
AGCGGCUCGGCCAUUUUGUCCCAGUCAGUCCGGAGGCUGCGGCUGCAGAAGUACCGCCUGCGGAGUAACUGCAAAGGCCACCAUGGAACUGCUGAUCCUGAAGGCCAACGCCAUCACCACCAUCCUGACCGCCGUGACCUUCUGUUUUGCCAGCGGCCAGAACAUCACCGAGGAAUUCUACCAGAGCACCUGUAGCGCCGUGUCCAAGGGAUAUCUGGGCGCCCUUAGAACCGGCUGGUACACCUGCGUGAUCACCAUCGAGCUGAGCAACAUCAAAGAAAACAAGUGCAACGGCACCGACGCCAAAGUGAAGCUGAUCAAGCAAGAGCUGGACAAGUACAAGAAUGCCGUGACCGACCUGCAGCUGCUGAUGCAGUCUACACCAGCCACAGGCUCUGGCAGCGCCAUUUGUUCUGGUGUCGCCGUGUCUAAAGUGCUGCACCUGGAAGGCGAAGUGAACAAGAUCAAGAGCGCCCUGCUGAGCACCAACAAGGCCGUGGUGUCUCUGAGCAAUGGCGUGUCCGUGUGCACCUUCAAGGUGCUGGACCUGAAGAACUACAUCGACAAACAGCUGCUGCCCAUCGUCAACAAGCAGUCCUGCAGCAUCCCCAACAUCGAGAUCGUGAUCGAGUUCCAGCAGAAGAACAACCGGCUGCUGGAAAUCACCCGCGAGUUCUCUGUGAAUGCCGGCGUGACCACACCUGUGUCCACCUACAUGCUGACCAACAGCGAGCUGCUGAGCCUGAUCAACGACAUGCCCAUCACCAACGACCAGAAAAAGCUGAUGAGCAACAACGUGCAGAUCGUGCGGCAGCAGAGCUACAGCAUCAUGAGCAUUAUCAAAGAAGAGGUGCUGGCCUACGUGGUGCAGCUGCCUCUGUAUGGCGUGAUCGAUACCCCUUGCUGGAAGCUGCACACAAGCCCUCUGUGCACCACCAACACCAAAGAGGGCAGCAACAUCUGCCUGACCAGAACCGACAGAGGCUGGUACUGCGAUAAUGCCGGCAGCGUCUCAUUCUUCCCACAAGCCGAGACAUGCAAGGUGCAGAGCAACCGGGUGUUCUGCGACACCAUGAAUAGCAGAACCCUGCCUUCCGAAGUGAAUCUGUGCAACGUGGACAUCUUCAACCCUAAGUACGACUGCAAGAUCAUGACCAGCAAGACCGACGUGUCCAGCAGUGUGAUCACCUCACUGGGCGCCAUCGUGUCCUGUUACGGCAAGACCAAGUGCACCGCCAGCAACAAGAACCGGGGCAUCAUCAAGACCUUCAGCAACGGCUGCGACUACGUGUCCAACAAAGGCGUGGACACCGUGUCUGUGGGCAACACCCUGUACUGCGUGAACAAACAAGAGGGCCAGUCUCUGUACGUGAAGGGCGAGCCCAUCAUCAACUUCUACGACCCUCUGGUGUUCCCCAGCAGCGAGUUCGAUGCCAGCAUCAGCCAAGUGAACGAGAAGAUCAAUCAGAGCCUGGCCUUCAUCAGAAAGUCCGAUGAGCUGCUGCACAACGUGAACGCCGGCAAGUCCACCACCAAUAUCAUGAUCACGACCAUCAUCAUCGUGAUUAUCGUGAUCCUGCUGUCCCUGAUCGCCGUGGGCCUGCUGCUUUAUUGAUAAUAGGCUGGAGCCUCGGUGGCCAUGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCUUCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
70. YK-RSV-022 DNA, SEQ ID NO: 70
AGCGGCTCGGCCATTTTGTCCCAGTCAGTCCGGAGGCTGCGGCTGCAGAAGTACCGCCTGCGGAGTAACTGCAAAGGCCACCATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCAGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCTGCGGCTCTGGCAGCGCCTGCGCTTCTGGTGTCGCCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCGGCTGCGGCGTGTCCGTGCTGACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCGTCAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGAGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGTGCCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTACGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCAGCGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAGGCTGGAGCCTCGGTGGCCATGCTTCTTGCCCCTTGGGCCTCCCCCCAGCCCCTCCTCCCCTTCCTGCACCCGTACCCCCGTGGTCTTTGAATAAAGTCTGAGTGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
71. YK-RSV-022 ORF NT, SEQ ID NO: 71
ATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCAGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCTGCGGCTCTGGCAGCGCCTGCGCTTCTGGTGTCGCCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCGGCTGCGGCGTGTCCGTGCTGACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCGTCAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGAGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGTGCCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTACGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCAGCGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAG
72. YK-RSV-022 ORF AA, SEQ ID NO: 72
MELLILKANAITTILTAVTFCFASGQNITEEFYQSTCSAVSKGYLGALRTGWYTSVITIELSNIKENKCNGTDAKVKLIKQELDKYKNAVTDLQLLMQSTPACGSGSACASGVAVSKVLHLEGEVNKIKSALLSTNKAVVSLSGCGVSVLTFKVLDLKNYIDKQLLPIVNKQSCSIPNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMSIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSRTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKCRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEGQSLYVKGEPIINFYDPLVFPSSEFDASISQVNEKINQSLAFIRKSDELLHNVNAGKSTTNIMITTIIIVIIVILLSLIAVGLLLY
73. YK-RSV-022 mRNA, SEQ ID NO: 73
AGCGGCUCGGCCAUUUUGUCCCAGUCAGUCCGGAGGCUGCGGCUGCAGAAGUACCGCCUGCGGAGUAACUGCAAAGGCCACCAUGGAACUGCUGAUCCUGAAGGCCAACGCCAUCACCACCAUCCUGACCGCCGUGACCUUCUGUUUUGCCAGCGGCCAGAACAUCACCGAGGAAUUCUACCAGAGCACCUGUAGCGCCGUGUCCAAGGGAUAUCUGGGCGCCCUUAGAACCGGCUGGUACACCAGCGUGAUCACCAUCGAGCUGAGCAACAUCAAAGAAAACAAGUGCAACGGCACCGACGCCAAAGUGAAGCUGAUCAAGCAAGAGCUGGACAAGUACAAGAAUGCCGUGACCGACCUGCAGCUGCUGAUGCAGUCUACACCAGCCUGCGGCUCUGGCAGCGCCUGCGCUUCUGGUGUCGCCGUGUCUAAAGUGCUGCACCUGGAAGGCGAAGUGAACAAGAUCAAGAGCGCCCUGCUGAGCACCAACAAGGCCGUGGUGUCUCUGAGCGGCUGCGGCGUGUCCGUGCUGACCUUCAAGGUGCUGGACCUGAAGAACUACAUCGACAAACAGCUGCUGCCCAUCGUCAACAAGCAGUCCUGCAGCAUCCCCAACAUCGAGACAGUGAUCGAGUUCCAGCAGAAGAACAACCGGCUGCUGGAAAUCACCCGCGAGUUCUCUGUGAAUGCCGGCGUGACCACACCUGUGUCCACCUACAUGCUGACCAACAGCGAGCUGCUGAGCCUGAUCAACGACAUGCCCAUCACCAACGACCAGAAAAAGCUGAUGAGCAACAACGUGCAGAUCGUGCGGCAGCAGAGCUACAGCAUCAUGAGCAUUAUCAAAGAAGAGGUGCUGGCCUACGUGGUGCAGCUGCCUCUGUAUGGCGUGAUCGAUACCCCUUGCUGGAAGCUGCACACAAGCCCUCUGUGCACCACCAACACCAAAGAGGGCAGCAACAUCUGCCUGACCAGAACCGACAGAGGCUGGUACUGCGAUAAUGCCGGCAGCGUCUCAUUCUUCCCACAAGCCGAGACAUGCAAGGUGCAGAGCAACCGGGUGUUCUGCGACACCAUGAAUAGCAGAACCCUGCCUUCCGAAGUGAAUCUGUGCAACGUGGACAUCUUCAACCCUAAGUACGACUGCAAGAUCAUGACCAGCAAGACCGACGUGUCCAGCAGUGUGAUCACCUCACUGGGCGCCAUCGUGUCCUGUUACGGCAAGACCAAGUGCACCGCCAGCAACAAGUGCCGGGGCAUCAUCAAGACCUUCAGCAACGGCUGCGACUACGUGUCCAACAAAGGCGUGGACACCGUGUCUGUGGGCAACACCCUGUACUACGUGAACAAACAAGAGGGCCAGUCUCUGUACGUGAAGGGCGAGCCCAUCAUCAACUUCUACGACCCUCUGGUGUUCCCCAGCAGCGAGUUCGAUGCCAGCAUCAGCCAAGUGAACGAGAAGAUCAAUCAGAGCCUGGCCUUCAUCAGAAAGUCCGAUGAGCUGCUGCACAACGUGAACGCCGGCAAGUCCACCACCAAUAUCAUGAUCACGACCAUCAUCAUCGUGAUUAUCGUGAUCCUGCUGUCCCUGAUCGCCGUGGGCCUGCUGCUUUAUUGAUAAUAGGCUGGAGCCUCGGUGGCCAUGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCUUCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
74. YK-RSV-029 DNA, SEQ ID NO: 74
AGCGGCTCGGCCATTTTGTCCCAGTCAGTCCGGAGGCTGCGGCTGCAGAAGTACCGCCTGCGGAGTAACTGCAAAGGCCACCATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCTGCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCAGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCAGCGCCATTGCCTCTGGTGTCGCCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCCTGAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGAGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTACGTGAACAAACAAGAGGGCTGCTCTCTGTACGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCGACGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAGGCTGGAGCCTCGGTGGCCATGCTTCTTGCCCCTTGGGCCTCCCCCCAGCCCCTCCTCCCCTTCCTGCACCCGTACCCCCGTGGTCTTTGAATAAAGTCTGAGTGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
75. YK-RSV-029 ORF NT, SEQ ID NO: 75
ATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCTGCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCAGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCAGCGCCATTGCCTCTGGTGTCGCCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCCTGAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGAGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTACGTGAACAAACAAGAGGGCTGCTCTCTGTACGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCGACGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAG
76. YK-RSV-029 ORF AA, SEQ ID NO: 76
MELLILKANAITTILTAVTFCFASGQNICEEFYQSTCSAVSKGYLGALRTGWYTSVITIELSNIKENKCNGTDAKVKLIKQELDKYKNAVTDLQLLMQSTPATGSGSAIASGVAVSKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTFKVLDLKNYIDKQLLPILNKQSCSIPNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMSIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSRTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEGCSLYVKGEPIINFYDPLVFPSDEFDASISQVNEKINQSLAFIRKSDELLHNVNAGKSTTNIMITTIIIVIIVILLSLIAVGLLLY
77. YK-RSV-029 mRNA, SEQ ID NO: 77
AGCGGCUCGGCCAUUUUGUCCCAGUCAGUCCGGAGGCUGCGGCUGCAGAAGUACCGCCUGCGGAGUAACUGCAAAGGCCACCAUGGAACUGCUGAUCCUGAAGGCCAACGCCAUCACCACCAUCCUGACCGCCGUGACCUUCUGUUUUGCCAGCGGCCAGAACAUCUGCGAGGAAUUCUACCAGAGCACCUGUAGCGCCGUGUCCAAGGGAUAUCUGGGCGCCCUUAGAACCGGCUGGUACACCAGCGUGAUCACCAUCGAGCUGAGCAACAUCAAAGAAAACAAGUGCAACGGCACCGACGCCAAAGUGAAGCUGAUCAAGCAAGAGCUGGACAAGUACAAGAAUGCCGUGACCGACCUGCAGCUGCUGAUGCAGUCUACACCAGCCACAGGCUCUGGCAGCGCCAUUGCCUCUGGUGUCGCCGUGUCUAAAGUGCUGCACCUGGAAGGCGAAGUGAACAAGAUCAAGAGCGCCCUGCUGAGCACCAACAAGGCCGUGGUGUCUCUGAGCAAUGGCGUGUCCGUGCUGACCUUCAAGGUGCUGGACCUGAAGAACUACAUCGACAAACAGCUGCUGCCCAUCCUGAACAAGCAGUCCUGCAGCAUCCCCAACAUCGAGACAGUGAUCGAGUUCCAGCAGAAGAACAACCGGCUGCUGGAAAUCACCCGCGAGUUCUCUGUGAAUGCCGGCGUGACCACACCUGUGUCCACCUACAUGCUGACCAACAGCGAGCUGCUGAGCCUGAUCAACGACAUGCCCAUCACCAACGACCAGAAAAAGCUGAUGAGCAACAACGUGCAGAUCGUGCGGCAGCAGAGCUACAGCAUCAUGAGCAUUAUCAAAGAAGAGGUGCUGGCCUACGUGGUGCAGCUGCCUCUGUAUGGCGUGAUCGAUACCCCUUGCUGGAAGCUGCACACAAGCCCUCUGUGCACCACCAACACCAAAGAGGGCAGCAACAUCUGCCUGACCAGAACCGACAGAGGCUGGUACUGCGAUAAUGCCGGCAGCGUCUCAUUCUUCCCACAAGCCGAGACAUGCAAGGUGCAGAGCAACCGGGUGUUCUGCGACACCAUGAAUAGCAGAACCCUGCCUUCCGAAGUGAAUCUGUGCAACGUGGACAUCUUCAACCCUAAGUACGACUGCAAGAUCAUGACCAGCAAGACCGACGUGUCCAGCAGUGUGAUCACCUCACUGGGCGCCAUCGUGUCCUGUUACGGCAAGACCAAGUGCACCGCCAGCAACAAGAACCGGGGCAUCAUCAAGACCUUCAGCAACGGCUGCGACUACGUGUCCAACAAAGGCGUGGACACCGUGUCUGUGGGCAACACCCUGUACUACGUGAACAAACAAGAGGGCUGCUCUCUGUACGUGAAGGGCGAGCCCAUCAUCAACUUCUACGACCCUCUGGUGUUCCCCAGCGACGAGUUCGAUGCCAGCAUCAGCCAAGUGAACGAGAAGAUCAAUCAGAGCCUGGCCUUCAUCAGAAAGUCCGAUGAGCUGCUGCACAACGUGAACGCCGGCAAGUCCACCACCAAUAUCAUGAUCACGACCAUCAUCAUCGUGAUUAUCGUGAUCCUGCUGUCCCUGAUCGCCGUGGGCCUGCUGCUUUAUUGAUAAUAGGCUGGAGCCUCGGUGGCCAUGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCUUCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
78. YK-RSV-030 DNA, SEQ ID NO: 78
AGCGGCTCGGCCATTTTGTCCCAGTCAGTCCGGAGGCTGCGGCTGCAGAAGTACCGCCTGCGGAGTAACTGCAAAGGCCACCATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGTGCTTCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCAGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCAGCGCCATTGCCTCTGGTGTCGCCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCCTGAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGAGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTACGTGAACAAACAAGAGGGCCAGTCTTGCTACGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCGACGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAGGCTGGAGCCTCGGTGGCCATGCTTCTTGCCCCTTGGGCCTCCCCCCAGCCCCTCCTCCCCTTCCTGCACCCGTACCCCCGTGGTCTTTGAATAAAGTCTGAGTGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
79. YK-RSV-030 ORF NT, SEQ ID NO: 79
ATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGTGCTTCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCAGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCAGCGCCATTGCCTCTGGTGTCGCCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCCTGAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGAGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTACGTGAACAAACAAGAGGGCCAGTCTTGCTACGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCGACGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAG
80. YK-RSV-030 ORF AA, SEQ ID NO: 80
MELLILKANAITTILTAVTFCFASGQNITECFYQSTCSAVSKGYLGALRTGWYTSVITIELSNIKENKCNGTDAKVKLIKQELDKYKNAVTDLQLLMQSTPATGSGSAIASGVAVSKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTFKVLDLKNYIDKQLLPILNKQSCSIPNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMSIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSRTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEGQSCYVKGEPIINFYDPLVFPSDEFDASISQVNEKINQSLAFIRKSDELLHNVNAGKSTTNIMITTIIIVIIVILLSLIAVGLLLY
81. YK-RSV-030 mRNA, SEQ ID NO: 81
AGCGGCUCGGCCAUUUUGUCCCAGUCAGUCCGGAGGCUGCGGCUGCAGAAGUACCGCCUGCGGAGUAACUGCAAAGGCCACCAUGGAACUGCUGAUCCUGAAGGCCAACGCCAUCACCACCAUCCUGACCGCCGUGACCUUCUGUUUUGCCAGCGGCCAGAACAUCACCGAGUGCUUCUACCAGAGCACCUGUAGCGCCGUGUCCAAGGGAUAUCUGGGCGCCCUUAGAACCGGCUGGUACACCAGCGUGAUCACCAUCGAGCUGAGCAACAUCAAAGAAAACAAGUGCAACGGCACCGACGCCAAAGUGAAGCUGAUCAAGCAAGAGCUGGACAAGUACAAGAAUGCCGUGACCGACCUGCAGCUGCUGAUGCAGUCUACACCAGCCACAGGCUCUGGCAGCGCCAUUGCCUCUGGUGUCGCCGUGUCUAAAGUGCUGCACCUGGAAGGCGAAGUGAACAAGAUCAAGAGCGCCCUGCUGAGCACCAACAAGGCCGUGGUGUCUCUGAGCAAUGGCGUGUCCGUGCUGACCUUCAAGGUGCUGGACCUGAAGAACUACAUCGACAAACAGCUGCUGCCCAUCCUGAACAAGCAGUCCUGCAGCAUCCCCAACAUCGAGACAGUGAUCGAGUUCCAGCAGAAGAACAACCGGCUGCUGGAAAUCACCCGCGAGUUCUCUGUGAAUGCCGGCGUGACCACACCUGUGUCCACCUACAUGCUGACCAACAGCGAGCUGCUGAGCCUGAUCAACGACAUGCCCAUCACCAACGACCAGAAAAAGCUGAUGAGCAACAACGUGCAGAUCGUGCGGCAGCAGAGCUACAGCAUCAUGAGCAUUAUCAAAGAAGAGGUGCUGGCCUACGUGGUGCAGCUGCCUCUGUAUGGCGUGAUCGAUACCCCUUGCUGGAAGCUGCACACAAGCCCUCUGUGCACCACCAACACCAAAGAGGGCAGCAACAUCUGCCUGACCAGAACCGACAGAGGCUGGUACUGCGAUAAUGCCGGCAGCGUCUCAUUCUUCCCACAAGCCGAGACAUGCAAGGUGCAGAGCAACCGGGUGUUCUGCGACACCAUGAAUAGCAGAACCCUGCCUUCCGAAGUGAAUCUGUGCAACGUGGACAUCUUCAACCCUAAGUACGACUGCAAGAUCAUGACCAGCAAGACCGACGUGUCCAGCAGUGUGAUCACCUCACUGGGCGCCAUCGUGUCCUGUUACGGCAAGACCAAGUGCACCGCCAGCAACAAGAACCGGGGCAUCAUCAAGACCUUCAGCAACGGCUGCGACUACGUGUCCAACAAAGGCGUGGACACCGUGUCUGUGGGCAACACCCUGUACUACGUGAACAAACAAGAGGGCCAGUCUUGCUACGUGAAGGGCGAGCCCAUCAUCAACUUCUACGACCCUCUGGUGUUCCCCAGCGACGAGUUCGAUGCCAGCAUCAGCCAAGUGAACGAGAAGAUCAAUCAGAGCCUGGCCUUCAUCAGAAAGUCCGAUGAGCUGCUGCACAACGUGAACGCCGGCAAGUCCACCACCAAUAUCAUGAUCACGACCAUCAUCAUCGUGAUUAUCGUGAUCCUGCUGUCCCUGAUCGCCGUGGGCCUGCUGCUUUAUUGAUAAUAGGCUGGAGCCUCGGUGGCCAUGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCUUCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
82. YK-RSV-031 DNA, SEQ ID NO: 82
AGCGGCTCGGCCATTTTGTCCCAGTCAGTCCGGAGGCTGCGGCTGCAGAAGTACCGCCTGCGGAGTAACTGCAAAGGCCACCATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATGCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCAGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCAGCGCCATTGCCTCTGGTGTCGCCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCCTGAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGAGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTACGTGAACAAACAAGAGGGCCAGTCTCTGTGCGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCGACGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAGGCTGGAGCCTCGGTGGCCATGCTTCTTGCCCCTTGGGCCTCCCCCCAGCCCCTCCTCCCCTTCCTGCACCCGTACCCCCGTGGTCTTTGAATAAAGTCTGAGTGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
83. YK-RSV-031 ORF NT, SEQ ID NO: 83
ATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATGCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCAGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCAGCGCCATTGCCTCTGGTGTCGCCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCCTGAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGAGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTACGTGAACAAACAAGAGGGCCAGTCTCTGTGCGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCGACGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAG
84. YK-RSV-031 ORF AA, SEQ ID NO: 84
MELLILKANAITTILTAVTFCFASGQNITEECYQSTCSAVSKGYLGALRTGWYTSVITIELSNIKENKCNGTDAKVKLIKQELDKYKNAVTDLQLLMQSTPATGSGSAIASGVAVSKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTFKVLDLKNYIDKQLLPILNKQSCSIPNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMSIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSRTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEGQSLCVKGEPIINFYDPLVFPSDEFDASISQVNEKINQSLAFIRKSDELLHNVNAGKSTTNIMITTIIIVIIVILLSLIAVGLLLY
85. YK-RSV-031 mRNA, SEQ ID NO: 85
AGCGGCUCGGCCAUUUUGUCCCAGUCAGUCCGGAGGCUGCGGCUGCAGAAGUACCGCCUGCGGAGUAACUGCAAAGGCCACCAUGGAACUGCUGAUCCUGAAGGCCAACGCCAUCACCACCAUCCUGACCGCCGUGACCUUCUGUUUUGCCAGCGGCCAGAACAUCACCGAGGAAUGCUACCAGAGCACCUGUAGCGCCGUGUCCAAGGGAUAUCUGGGCGCCCUUAGAACCGGCUGGUACACCAGCGUGAUCACCAUCGAGCUGAGCAACAUCAAAGAAAACAAGUGCAACGGCACCGACGCCAAAGUGAAGCUGAUCAAGCAAGAGCUGGACAAGUACAAGAAUGCCGUGACCGACCUGCAGCUGCUGAUGCAGUCUACACCAGCCACAGGCUCUGGCAGCGCCAUUGCCUCUGGUGUCGCCGUGUCUAAAGUGCUGCACCUGGAAGGCGAAGUGAACAAGAUCAAGAGCGCCCUGCUGAGCACCAACAAGGCCGUGGUGUCUCUGAGCAAUGGCGUGUCCGUGCUGACCUUCAAGGUGCUGGACCUGAAGAACUACAUCGACAAACAGCUGCUGCCCAUCCUGAACAAGCAGUCCUGCAGCAUCCCCAACAUCGAGACAGUGAUCGAGUUCCAGCAGAAGAACAACCGGCUGCUGGAAAUCACCCGCGAGUUCUCUGUGAAUGCCGGCGUGACCACACCUGUGUCCACCUACAUGCUGACCAACAGCGAGCUGCUGAGCCUGAUCAACGACAUGCCCAUCACCAACGACCAGAAAAAGCUGAUGAGCAACAACGUGCAGAUCGUGCGGCAGCAGAGCUACAGCAUCAUGAGCAUUAUCAAAGAAGAGGUGCUGGCCUACGUGGUGCAGCUGCCUCUGUAUGGCGUGAUCGAUACCCCUUGCUGGAAGCUGCACACAAGCCCUCUGUGCACCACCAACACCAAAGAGGGCAGCAACAUCUGCCUGACCAGAACCGACAGAGGCUGGUACUGCGAUAAUGCCGGCAGCGUCUCAUUCUUCCCACAAGCCGAGACAUGCAAGGUGCAGAGCAACCGGGUGUUCUGCGACACCAUGAAUAGCAGAACCCUGCCUUCCGAAGUGAAUCUGUGCAACGUGGACAUCUUCAACCCUAAGUACGACUGCAAGAUCAUGACCAGCAAGACCGACGUGUCCAGCAGUGUGAUCACCUCACUGGGCGCCAUCGUGUCCUGUUACGGCAAGACCAAGUGCACCGCCAGCAACAAGAACCGGGGCAUCAUCAAGACCUUCAGCAACGGCUGCGACUACGUGUCCAACAAAGGCGUGGACACCGUGUCUGUGGGCAACACCCUGUACUACGUGAACAAACAAGAGGGCCAGUCUCUGUGCGUGAAGGGCGAGCCCAUCAUCAACUUCUACGACCCUCUGGUGUUCCCCAGCGACGAGUUCGAUGCCAGCAUCAGCCAAGUGAACGAGAAGAUCAAUCAGAGCCUGGCCUUCAUCAGAAAGUCCGAUGAGCUGCUGCACAACGUGAACGCCGGCAAGUCCACCACCAAUAUCAUGAUCACGACCAUCAUCAUCGUGAUUAUCGUGAUCCUGCUGUCCCUGAUCGCCGUGGGCCUGCUGCUUUAUUGAUAAUAGGCUGGAGCCUCGGUGGCCAUGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCUUCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
86. YK-RSV-032 DNA, SEQ ID NO: 86
AGCGGCTCGGCCATTTTGTCCCAGTCAGTCCGGAGGCTGCGGCTGCAGAAGTACCGCCTGCGGAGTAACTGCAAAGGCCACCATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACTGCAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCAGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCAGCGCCATTGCCTCTGGTGTCGCCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCCTGAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGAGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTACGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGTGCGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCGACGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAGGCTGGAGCCTCGGTGGCCATGCTTCTTGCCCCTTGGGCCTCCCCCCAGCCCCTCCTCCCCTTCCTGCACCCGTACCCCCGTGGTCTTTGAATAAAGTCTGAGTGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
87. YK-RSV-032 ORF NT, SEQ ID NO: 87
ATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACTGCAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCAGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCAGCGCCATTGCCTCTGGTGTCGCCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCCTGAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGAGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTACGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGTGCGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCGACGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAG
88. YK-RSV-032 ORF AA, SEQ ID NO: 88
MELLILKANAITTILTAVTFCFASGQNITEEFYCSTCSAVSKGYLGALRTGWYTSVITIELSNIKENKCNGTDAKVKLIKQELDKYKNAVTDLQLLMQSTPATGSGSAIASGVAVSKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTFKVLDLKNYIDKQLLPILNKQSCSIPNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMSIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSRTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEGQSLYVCGEPIINFYDPLVFPSDEFDASISQVNEKINQSLAFIRKSDELLHNVNAGKSTTNIMITTIIIVIIVILLSLIAVGLLLY
89. YK-RSV-032 mRNA, SEQ ID NO: 89
AGCGGCUCGGCCAUUUUGUCCCAGUCAGUCCGGAGGCUGCGGCUGCAGAAGUACCGCCUGCGGAGUAACUGCAAAGGCCACCAUGGAACUGCUGAUCCUGAAGGCCAACGCCAUCACCACCAUCCUGACCGCCGUGACCUUCUGUUUUGCCAGCGGCCAGAACAUCACCGAGGAAUUCUACUGCAGCACCUGUAGCGCCGUGUCCAAGGGAUAUCUGGGCGCCCUUAGAACCGGCUGGUACACCAGCGUGAUCACCAUCGAGCUGAGCAACAUCAAAGAAAACAAGUGCAACGGCACCGACGCCAAAGUGAAGCUGAUCAAGCAAGAGCUGGACAAGUACAAGAAUGCCGUGACCGACCUGCAGCUGCUGAUGCAGUCUACACCAGCCACAGGCUCUGGCAGCGCCAUUGCCUCUGGUGUCGCCGUGUCUAAAGUGCUGCACCUGGAAGGCGAAGUGAACAAGAUCAAGAGCGCCCUGCUGAGCACCAACAAGGCCGUGGUGUCUCUGAGCAAUGGCGUGUCCGUGCUGACCUUCAAGGUGCUGGACCUGAAGAACUACAUCGACAAACAGCUGCUGCCCAUCCUGAACAAGCAGUCCUGCAGCAUCCCCAACAUCGAGACAGUGAUCGAGUUCCAGCAGAAGAACAACCGGCUGCUGGAAAUCACCCGCGAGUUCUCUGUGAAUGCCGGCGUGACCACACCUGUGUCCACCUACAUGCUGACCAACAGCGAGCUGCUGAGCCUGAUCAACGACAUGCCCAUCACCAACGACCAGAAAAAGCUGAUGAGCAACAACGUGCAGAUCGUGCGGCAGCAGAGCUACAGCAUCAUGAGCAUUAUCAAAGAAGAGGUGCUGGCCUACGUGGUGCAGCUGCCUCUGUAUGGCGUGAUCGAUACCCCUUGCUGGAAGCUGCACACAAGCCCUCUGUGCACCACCAACACCAAAGAGGGCAGCAACAUCUGCCUGACCAGAACCGACAGAGGCUGGUACUGCGAUAAUGCCGGCAGCGUCUCAUUCUUCCCACAAGCCGAGACAUGCAAGGUGCAGAGCAACCGGGUGUUCUGCGACACCAUGAAUAGCAGAACCCUGCCUUCCGAAGUGAAUCUGUGCAACGUGGACAUCUUCAACCCUAAGUACGACUGCAAGAUCAUGACCAGCAAGACCGACGUGUCCAGCAGUGUGAUCACCUCACUGGGCGCCAUCGUGUCCUGUUACGGCAAGACCAAGUGCACCGCCAGCAACAAGAACCGGGGCAUCAUCAAGACCUUCAGCAACGGCUGCGACUACGUGUCCAACAAAGGCGUGGACACCGUGUCUGUGGGCAACACCCUGUACUACGUGAACAAACAAGAGGGCCAGUCUCUGUACGUGUGCGGCGAGCCCAUCAUCAACUUCUACGACCCUCUGGUGUUCCCCAGCGACGAGUUCGAUGCCAGCAUCAGCCAAGUGAACGAGAAGAUCAAUCAGAGCCUGGCCUUCAUCAGAAAGUCCGAUGAGCUGCUGCACAACGUGAACGCCGGCAAGUCCACCACCAAUAUCAUGAUCACGACCAUCAUCAUCGUGAUUAUCGUGAUCCUGCUGUCCCUGAUCGCCGUGGGCCUGCUGCUUUAUUGAUAAUAGGCUGGAGCCUCGGUGGCCAUGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCUUCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
90. YK-RSV-033 DNA, SEQ ID NO: 90
AGCGGCTCGGCCATTTTGTCCCAGTCAGTCCGGAGGCTGCGGCTGCAGAAGTACCGCCTGCGGAGTAACTGCAAAGGCCACCATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACCAGAGCTGCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCAGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCAGCGCCATTGCCTCTGGTGTCGCCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCCTGAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGAGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTACGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGTGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCGACGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAGGCTGGAGCCTCGGTGGCCATGCTTCTTGCCCCTTGGGCCTCCCCCCAGCCCCTCCTCCCCTTCCTGCACCCGTACCCCCGTGGTCTTTGAATAAAGTCTGAGTGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
91. YK-RSV-033 ORF NT, SEQ ID NO: 91
ATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACCAGAGCTGCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCAGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCAGCGCCATTGCCTCTGGTGTCGCCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCCTGAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGAGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTACGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGTGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCGACGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAG
92. YK-RSV-033 ORF AA, SEQ ID NO: 92
MELLILKANAITTILTAVTFCFASGQNITEEFYQSCCSAVSKGYLGALRTGWYTSVITIELSNIKENKCNGTDAKVKLIKQELDKYKNAVTDLQLLMQSTPATGSGSAIASGVAVSKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTFKVLDLKNYIDKQLLPILNKQSCSIPNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMSIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSRTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEGQSLYVKCEPIINFYDPLVFPSDEFDASISQVNEKINQSLAFIRKSDELLHNVNAGKSTTNIMITTIIIVIIVILLSLIAVGLLLY
93. YK-RSV-033 mRNA, SEQ ID NO: 93
AGCGGCUCGGCCAUUUUGUCCCAGUCAGUCCGGAGGCUGCGGCUGCAGAAGUACCGCCUGCGGAGUAACUGCAAAGGCCACCAUGGAACUGCUGAUCCUGAAGGCCAACGCCAUCACCACCAUCCUGACCGCCGUGACCUUCUGUUUUGCCAGCGGCCAGAACAUCACCGAGGAAUUCUACCAGAGCUGCUGUAGCGCCGUGUCCAAGGGAUAUCUGGGCGCCCUUAGAACCGGCUGGUACACCAGCGUGAUCACCAUCGAGCUGAGCAACAUCAAAGAAAACAAGUGCAACGGCACCGACGCCAAAGUGAAGCUGAUCAAGCAAGAGCUGGACAAGUACAAGAAUGCCGUGACCGACCUGCAGCUGCUGAUGCAGUCUACACCAGCCACAGGCUCUGGCAGCGCCAUUGCCUCUGGUGUCGCCGUGUCUAAAGUGCUGCACCUGGAAGGCGAAGUGAACAAGAUCAAGAGCGCCCUGCUGAGCACCAACAAGGCCGUGGUGUCUCUGAGCAAUGGCGUGUCCGUGCUGACCUUCAAGGUGCUGGACCUGAAGAACUACAUCGACAAACAGCUGCUGCCCAUCCUGAACAAGCAGUCCUGCAGCAUCCCCAACAUCGAGACAGUGAUCGAGUUCCAGCAGAAGAACAACCGGCUGCUGGAAAUCACCCGCGAGUUCUCUGUGAAUGCCGGCGUGACCACACCUGUGUCCACCUACAUGCUGACCAACAGCGAGCUGCUGAGCCUGAUCAACGACAUGCCCAUCACCAACGACCAGAAAAAGCUGAUGAGCAACAACGUGCAGAUCGUGCGGCAGCAGAGCUACAGCAUCAUGAGCAUUAUCAAAGAAGAGGUGCUGGCCUACGUGGUGCAGCUGCCUCUGUAUGGCGUGAUCGAUACCCCUUGCUGGAAGCUGCACACAAGCCCUCUGUGCACCACCAACACCAAAGAGGGCAGCAACAUCUGCCUGACCAGAACCGACAGAGGCUGGUACUGCGAUAAUGCCGGCAGCGUCUCAUUCUUCCCACAAGCCGAGACAUGCAAGGUGCAGAGCAACCGGGUGUUCUGCGACACCAUGAAUAGCAGAACCCUGCCUUCCGAAGUGAAUCUGUGCAACGUGGACAUCUUCAACCCUAAGUACGACUGCAAGAUCAUGACCAGCAAGACCGACGUGUCCAGCAGUGUGAUCACCUCACUGGGCGCCAUCGUGUCCUGUUACGGCAAGACCAAGUGCACCGCCAGCAACAAGAACCGGGGCAUCAUCAAGACCUUCAGCAACGGCUGCGACUACGUGUCCAACAAAGGCGUGGACACCGUGUCUGUGGGCAACACCCUGUACUACGUGAACAAACAAGAGGGCCAGUCUCUGUACGUGAAGUGCGAGCCCAUCAUCAACUUCUACGACCCUCUGGUGUUCCCCAGCGACGAGUUCGAUGCCAGCAUCAGCCAAGUGAACGAGAAGAUCAAUCAGAGCCUGGCCUUCAUCAGAAAGUCCGAUGAGCUGCUGCACAACGUGAACGCCGGCAAGUCCACCACCAAUAUCAUGAUCACGACCAUCAUCAUCGUGAUUAUCGUGAUCCUGCUGUCCCUGAUCGCCGUGGGCCUGCUGCUUUAUUGAUAAUAGGCUGGAGCCUCGGUGGCCAUGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCUUCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
94. YK-RSV-034 DNA, SEQ ID NO: 94
AGCGGCTCGGCCATTTTGTCCCAGTCAGTCCGGAGGCTGCGGCTGCAGAAGTACCGCCTGCGGAGTAACTGCAAAGGCCACCATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCTGCAACATCACCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCAGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCAGCGCCATTGCCTCTGGTGTCGCCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCCTGAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGAGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTACGTGAACTGCCAAGAGGGCCAGTCTCTGTACGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCGACGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAGGCTGGAGCCTCGGTGGCCATGCTTCTTGCCCCTTGGGCCTCCCCCCAGCCCCTCCTCCCCTTCCTGCACCCGTACCCCCGTGGTCTTTGAATAAAGTCTGAGTGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
95. YK-RSV-034 ORF NT, SEQ ID NO: 95
ATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCTGCAACATCACCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCAGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCAGCGCCATTGCCTCTGGTGTCGCCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCCTGAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGAGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTACGTGAACTGCCAAGAGGGCCAGTCTCTGTACGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCGACGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAG
96. YK-RSV-034 ORF AA, SEQ ID NO: 96
MELLILKANAITTILTAVTFCFASGCNITEEFYQSTCSAVSKGYLGALRTGWYTSVITIELSNIKENKCNGTDAKVKLIKQELDKYKNAVTDLQLLMQSTPATGSGSAIASGVAVSKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTFKVLDLKNYIDKQLLPILNKQSCSIPNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMSIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSRTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNCQEGQSLYVKGEPIINFYDPLVFPSDEFDASISQVNEKINQSLAFIRKSDELLHNVNAGKSTTNIMITTIIIVIIVILLSLIAVGLLLY
97. YK-RSV-034 mRNA, SEQ ID NO: 97
AGCGGCUCGGCCAUUUUGUCCCAGUCAGUCCGGAGGCUGCGGCUGCAGAAGUACCGCCUGCGGAGUAACUGCAAAGGCCACCAUGGAACUGCUGAUCCUGAAGGCCAACGCCAUCACCACCAUCCUGACCGCCGUGACCUUCUGUUUUGCCAGCGGCUGCAACAUCACCGAGGAAUUCUACCAGAGCACCUGUAGCGCCGUGUCCAAGGGAUAUCUGGGCGCCCUUAGAACCGGCUGGUACACCAGCGUGAUCACCAUCGAGCUGAGCAACAUCAAAGAAAACAAGUGCAACGGCACCGACGCCAAAGUGAAGCUGAUCAAGCAAGAGCUGGACAAGUACAAGAAUGCCGUGACCGACCUGCAGCUGCUGAUGCAGUCUACACCAGCCACAGGCUCUGGCAGCGCCAUUGCCUCUGGUGUCGCCGUGUCUAAAGUGCUGCACCUGGAAGGCGAAGUGAACAAGAUCAAGAGCGCCCUGCUGAGCACCAACAAGGCCGUGGUGUCUCUGAGCAAUGGCGUGUCCGUGCUGACCUUCAAGGUGCUGGACCUGAAGAACUACAUCGACAAACAGCUGCUGCCCAUCCUGAACAAGCAGUCCUGCAGCAUCCCCAACAUCGAGACAGUGAUCGAGUUCCAGCAGAAGAACAACCGGCUGCUGGAAAUCACCCGCGAGUUCUCUGUGAAUGCCGGCGUGACCACACCUGUGUCCACCUACAUGCUGACCAACAGCGAGCUGCUGAGCCUGAUCAACGACAUGCCCAUCACCAACGACCAGAAAAAGCUGAUGAGCAACAACGUGCAGAUCGUGCGGCAGCAGAGCUACAGCAUCAUGAGCAUUAUCAAAGAAGAGGUGCUGGCCUACGUGGUGCAGCUGCCUCUGUAUGGCGUGAUCGAUACCCCUUGCUGGAAGCUGCACACAAGCCCUCUGUGCACCACCAACACCAAAGAGGGCAGCAACAUCUGCCUGACCAGAACCGACAGAGGCUGGUACUGCGAUAAUGCCGGCAGCGUCUCAUUCUUCCCACAAGCCGAGACAUGCAAGGUGCAGAGCAACCGGGUGUUCUGCGACACCAUGAAUAGCAGAACCCUGCCUUCCGAAGUGAAUCUGUGCAACGUGGACAUCUUCAACCCUAAGUACGACUGCAAGAUCAUGACCAGCAAGACCGACGUGUCCAGCAGUGUGAUCACCUCACUGGGCGCCAUCGUGUCCUGUUACGGCAAGACCAAGUGCACCGCCAGCAACAAGAACCGGGGCAUCAUCAAGACCUUCAGCAACGGCUGCGACUACGUGUCCAACAAAGGCGUGGACACCGUGUCUGUGGGCAACACCCUGUACUACGUGAACUGCCAAGAGGGCCAGUCUCUGUACGUGAAGGGCGAGCCCAUCAUCAACUUCUACGACCCUCUGGUGUUCCCCAGCGACGAGUUCGAUGCCAGCAUCAGCCAAGUGAACGAGAAGAUCAAUCAGAGCCUGGCCUUCAUCAGAAAGUCCGAUGAGCUGCUGCACAACGUGAACGCCGGCAAGUCCACCACCAAUAUCAUGAUCACGACCAUCAUCAUCGUGAUUAUCGUGAUCCUGCUGUCCCUGAUCGCCGUGGGCCUGCUGCUUUAUUGAUAAUAGGCUGGAGCCUCGGUGGCCAUGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCUUCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
98. YK-RSV-035 DNA, SEQ ID NO: 98
AGCGGCTCGGCCATTTTGTCCCAGTCAGTCCGGAGGCTGCGGCTGCAGAAGTACCGCCTGCGGAGTAACTGCAAAGGCCACCATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGTGCATCACCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCAGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCAGCGCCATTGCCTCTGGTGTCGCCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCCTGAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGAGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTACGTGAACAAATGCGAGGGCCAGTCTCTGTACGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCGACGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAGGCTGGAGCCTCGGTGGCCATGCTTCTTGCCCCTTGGGCCTCCCCCCAGCCCCTCCTCCCCTTCCTGCACCCGTACCCCCGTGGTCTTTGAATAAAGTCTGAGTGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
99. YK-RSV-035 ORF NT, SEQ ID NO: 99
ATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGTGCATCACCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCAGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCAGCGCCATTGCCTCTGGTGTCGCCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCCTGAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGAGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTACGTGAACAAATGCGAGGGCCAGTCTCTGTACGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCGACGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAG
100. YK-RSV-035 ORF AA, SEQ ID NO: 100
MELLILKANAITTILTAVTFCFASGQCITEEFYQSTCSAVSKGYLGALRTGWYTSVITIELSNIKENKCNGTDAKVKLIKQELDKYKNAVTDLQLLMQSTPATGSGSAIASGVAVSKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTFKVLDLKNYIDKQLLPILNKQSCSIPNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMSIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSRTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKCEGQSLYVKGEPIINFYDPLVFPSDEFDASISQVNEKINQSLAFIRKSDELLHNVNAGKSTTNIMITTIIIVIIVILLSLIAVGLLLY
101. YK-RSV-035 mRNA, SEQ ID NO: 101
AGCGGCUCGGCCAUUUUGUCCCAGUCAGUCCGGAGGCUGCGGCUGCAGAAGUACCGCCUGCGGAGUAACUGCAAAGGCCACCAUGGAACUGCUGAUCCUGAAGGCCAACGCCAUCACCACCAUCCUGACCGCCGUGACCUUCUGUUUUGCCAGCGGCCAGUGCAUCACCGAGGAAUUCUACCAGAGCACCUGUAGCGCCGUGUCCAAGGGAUAUCUGGGCGCCCUUAGAACCGGCUGGUACACCAGCGUGAUCACCAUCGAGCUGAGCAACAUCAAAGAAAACAAGUGCAACGGCACCGACGCCAAAGUGAAGCUGAUCAAGCAAGAGCUGGACAAGUACAAGAAUGCCGUGACCGACCUGCAGCUGCUGAUGCAGUCUACACCAGCCACAGGCUCUGGCAGCGCCAUUGCCUCUGGUGUCGCCGUGUCUAAAGUGCUGCACCUGGAAGGCGAAGUGAACAAGAUCAAGAGCGCCCUGCUGAGCACCAACAAGGCCGUGGUGUCUCUGAGCAAUGGCGUGUCCGUGCUGACCUUCAAGGUGCUGGACCUGAAGAACUACAUCGACAAACAGCUGCUGCCCAUCCUGAACAAGCAGUCCUGCAGCAUCCCCAACAUCGAGACAGUGAUCGAGUUCCAGCAGAAGAACAACCGGCUGCUGGAAAUCACCCGCGAGUUCUCUGUGAAUGCCGGCGUGACCACACCUGUGUCCACCUACAUGCUGACCAACAGCGAGCUGCUGAGCCUGAUCAACGACAUGCCCAUCACCAACGACCAGAAAAAGCUGAUGAGCAACAACGUGCAGAUCGUGCGGCAGCAGAGCUACAGCAUCAUGAGCAUUAUCAAAGAAGAGGUGCUGGCCUACGUGGUGCAGCUGCCUCUGUAUGGCGUGAUCGAUACCCCUUGCUGGAAGCUGCACACAAGCCCUCUGUGCACCACCAACACCAAAGAGGGCAGCAACAUCUGCCUGACCAGAACCGACAGAGGCUGGUACUGCGAUAAUGCCGGCAGCGUCUCAUUCUUCCCACAAGCCGAGACAUGCAAGGUGCAGAGCAACCGGGUGUUCUGCGACACCAUGAAUAGCAGAACCCUGCCUUCCGAAGUGAAUCUGUGCAACGUGGACAUCUUCAACCCUAAGUACGACUGCAAGAUCAUGACCAGCAAGACCGACGUGUCCAGCAGUGUGAUCACCUCACUGGGCGCCAUCGUGUCCUGUUACGGCAAGACCAAGUGCACCGCCAGCAACAAGAACCGGGGCAUCAUCAAGACCUUCAGCAACGGCUGCGACUACGUGUCCAACAAAGGCGUGGACACCGUGUCUGUGGGCAACACCCUGUACUACGUGAACAAAUGCGAGGGCCAGUCUCUGUACGUGAAGGGCGAGCCCAUCAUCAACUUCUACGACCCUCUGGUGUUCCCCAGCGACGAGUUCGAUGCCAGCAUCAGCCAAGUGAACGAGAAGAUCAAUCAGAGCCUGGCCUUCAUCAGAAAGUCCGAUGAGCUGCUGCACAACGUGAACGCCGGCAAGUCCACCACCAAUAUCAUGAUCACGACCAUCAUCAUCGUGAUUAUCGUGAUCCUGCUGUCCCUGAUCGCCGUGGGCCUGCUGCUUUAUUGAUAAUAGGCUGGAGCCUCGGUGGCCAUGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCUUCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
102. YK-RSV-036 DNA, SEQ ID NO: 102
AGCGGCTCGGCCATTTTGTCCCAGTCAGTCCGGAGGCTGCGGCTGCAGAAGTACCGCCTGCGGAGTAACTGCAAAGGCCACCATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCTGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCAGCGCCATTGCCTCTGGTGTCGCCTGCTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCCTGAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGAGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTACGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCGACGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAGGCTGGAGCCTCGGTGGCCATGCTTCTTGCCCCTTGGGCCTCCCCCCAGCCCCTCCTCCCCTTCCTGCACCCGTACCCCCGTGGTCTTTGAATAAAGTCTGAGTGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
103. YK-RSV-036 ORF NT, SEQ ID NO: 103
ATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCTGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCAGCGCCATTGCCTCTGGTGTCGCCTGCTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCCTGAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGAGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTACGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCGACGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAG
104. YK-RSV-036 ORF AA, SEQ ID NO: 104
MELLILKANAITTILTAVTFCFASGQNITEEFYQSTCSAVSKGYLGALRTGWYTCVITIELSNIKENKCNGTDAKVKLIKQELDKYKNAVTDLQLLMQSTPATGSGSAIASGVACSKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTFKVLDLKNYIDKQLLPILNKQSCSIPNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMSIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSRTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEGQSLYVKGEPIINFYDPLVFPSDEFDASISQVNEKINQSLAFIRKSDELLHNVNAGKSTTNIMITTIIIVIIVILLSLIAVGLLLY
105. YK-RSV-036 mRNA, SEQ ID NO: 105
AGCGGCUCGGCCAUUUUGUCCCAGUCAGUCCGGAGGCUGCGGCUGCAGAAGUACCGCCUGCGGAGUAACUGCAAAGGCCACCAUGGAACUGCUGAUCCUGAAGGCCAACGCCAUCACCACCAUCCUGACCGCCGUGACCUUCUGUUUUGCCAGCGGCCAGAACAUCACCGAGGAAUUCUACCAGAGCACCUGUAGCGCCGUGUCCAAGGGAUAUCUGGGCGCCCUUAGAACCGGCUGGUACACCUGCGUGAUCACCAUCGAGCUGAGCAACAUCAAAGAAAACAAGUGCAACGGCACCGACGCCAAAGUGAAGCUGAUCAAGCAAGAGCUGGACAAGUACAAGAAUGCCGUGACCGACCUGCAGCUGCUGAUGCAGUCUACACCAGCCACAGGCUCUGGCAGCGCCAUUGCCUCUGGUGUCGCCUGCUCUAAAGUGCUGCACCUGGAAGGCGAAGUGAACAAGAUCAAGAGCGCCCUGCUGAGCACCAACAAGGCCGUGGUGUCUCUGAGCAAUGGCGUGUCCGUGCUGACCUUCAAGGUGCUGGACCUGAAGAACUACAUCGACAAACAGCUGCUGCCCAUCCUGAACAAGCAGUCCUGCAGCAUCCCCAACAUCGAGACAGUGAUCGAGUUCCAGCAGAAGAACAACCGGCUGCUGGAAAUCACCCGCGAGUUCUCUGUGAAUGCCGGCGUGACCACACCUGUGUCCACCUACAUGCUGACCAACAGCGAGCUGCUGAGCCUGAUCAACGACAUGCCCAUCACCAACGACCAGAAAAAGCUGAUGAGCAACAACGUGCAGAUCGUGCGGCAGCAGAGCUACAGCAUCAUGAGCAUUAUCAAAGAAGAGGUGCUGGCCUACGUGGUGCAGCUGCCUCUGUAUGGCGUGAUCGAUACCCCUUGCUGGAAGCUGCACACAAGCCCUCUGUGCACCACCAACACCAAAGAGGGCAGCAACAUCUGCCUGACCAGAACCGACAGAGGCUGGUACUGCGAUAAUGCCGGCAGCGUCUCAUUCUUCCCACAAGCCGAGACAUGCAAGGUGCAGAGCAACCGGGUGUUCUGCGACACCAUGAAUAGCAGAACCCUGCCUUCCGAAGUGAAUCUGUGCAACGUGGACAUCUUCAACCCUAAGUACGACUGCAAGAUCAUGACCAGCAAGACCGACGUGUCCAGCAGUGUGAUCACCUCACUGGGCGCCAUCGUGUCCUGUUACGGCAAGACCAAGUGCACCGCCAGCAACAAGAACCGGGGCAUCAUCAAGACCUUCAGCAACGGCUGCGACUACGUGUCCAACAAAGGCGUGGACACCGUGUCUGUGGGCAACACCCUGUACUACGUGAACAAACAAGAGGGCCAGUCUCUGUACGUGAAGGGCGAGCCCAUCAUCAACUUCUACGACCCUCUGGUGUUCCCCAGCGACGAGUUCGAUGCCAGCAUCAGCCAAGUGAACGAGAAGAUCAAUCAGAGCCUGGCCUUCAUCAGAAAGUCCGAUGAGCUGCUGCACAACGUGAACGCCGGCAAGUCCACCACCAAUAUCAUGAUCACGACCAUCAUCAUCGUGAUUAUCGUGAUCCUGCUGUCCCUGAUCGCCGUGGGCCUGCUGCUUUAUUGAUAAUAGGCUGGAGCCUCGGUGGCCAUGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCUUCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
106. YK-RSV-037 DNA, SEQ ID NO: 106
AGCGGCTCGGCCATTTTGTCCCAGTCAGTCCGGAGGCTGCGGCTGCAGAAGTACCGCCTGCGGAGTAACTGCAAAGGCCACCATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTGCACCAGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCAGCGCCATTGCCTCTGGTGTCTGCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCCTGAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGAGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTACGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCGACGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAGGCTGGAGCCTCGGTGGCCATGCTTCTTGCCCCTTGGGCCTCCCCCCAGCCCCTCCTCCCCTTCCTGCACCCGTACCCCCGTGGTCTTTGAATAAAGTCTGAGTGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
107. YK-RSV-037 ORF NT, SEQ ID NO: 107
ATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTGCACCAGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCAGCGCCATTGCCTCTGGTGTCTGCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCCTGAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGAGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTACGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCGACGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAG
108. YK-RSV-037 ORF AA, SEQ ID NO: 108
MELLILKANAITTILTAVTFCFASGQNITEEFYQSTCSAVSKGYLGALRTGWCTSVITIELSNIKENKCNGTDAKVKLIKQELDKYKNAVTDLQLLMQSTPATGSGSAIASGVCVSKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTFKVLDLKNYIDKQLLPILNKQSCSIPNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMSIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSRTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEGQSLYVKGEPIINFYDPLVFPSDEFDASISQVNEKINQSLAFIRKSDELLHNVNAGKSTTNIMITTIIIVIIVILLSLIAVGLLLY
109 YK-RSV-037 mRNA, SEQ ID NO: 109
AGCGGCUCGGCCAUUUUGUCCCAGUCAGUCCGGAGGCUGCGGCUGCAGAAGUACCGCCUGCGGAGUAACUGCAAAGGCCACCAUGGAACUGCUGAUCCUGAAGGCCAACGCCAUCACCACCAUCCUGACCGCCGUGACCUUCUGUUUUGCCAGCGGCCAGAACAUCACCGAGGAAUUCUACCAGAGCACCUGUAGCGCCGUGUCCAAGGGAUAUCUGGGCGCCCUUAGAACCGGCUGGUGCACCAGCGUGAUCACCAUCGAGCUGAGCAACAUCAAAGAAAACAAGUGCAACGGCACCGACGCCAAAGUGAAGCUGAUCAAGCAAGAGCUGGACAAGUACAAGAAUGCCGUGACCGACCUGCAGCUGCUGAUGCAGUCUACACCAGCCACAGGCUCUGGCAGCGCCAUUGCCUCUGGUGUCUGCGUGUCUAAAGUGCUGCACCUGGAAGGCGAAGUGAACAAGAUCAAGAGCGCCCUGCUGAGCACCAACAAGGCCGUGGUGUCUCUGAGCAAUGGCGUGUCCGUGCUGACCUUCAAGGUGCUGGACCUGAAGAACUACAUCGACAAACAGCUGCUGCCCAUCCUGAACAAGCAGUCCUGCAGCAUCCCCAACAUCGAGACAGUGAUCGAGUUCCAGCAGAAGAACAACCGGCUGCUGGAAAUCACCCGCGAGUUCUCUGUGAAUGCCGGCGUGACCACACCUGUGUCCACCUACAUGCUGACCAACAGCGAGCUGCUGAGCCUGAUCAACGACAUGCCCAUCACCAACGACCAGAAAAAGCUGAUGAGCAACAACGUGCAGAUCGUGCGGCAGCAGAGCUACAGCAUCAUGAGCAUUAUCAAAGAAGAGGUGCUGGCCUACGUGGUGCAGCUGCCUCUGUAUGGCGUGAUCGAUACCCCUUGCUGGAAGCUGCACACAAGCCCUCUGUGCACCACCAACACCAAAGAGGGCAGCAACAUCUGCCUGACCAGAACCGACAGAGGCUGGUACUGCGAUAAUGCCGGCAGCGUCUCAUUCUUCCCACAAGCCGAGACAUGCAAGGUGCAGAGCAACCGGGUGUUCUGCGACACCAUGAAUAGCAGAACCCUGCCUUCCGAAGUGAAUCUGUGCAACGUGGACAUCUUCAACCCUAAGUACGACUGCAAGAUCAUGACCAGCAAGACCGACGUGUCCAGCAGUGUGAUCACCUCACUGGGCGCCAUCGUGUCCUGUUACGGCAAGACCAAGUGCACCGCCAGCAACAAGAACCGGGGCAUCAUCAAGACCUUCAGCAACGGCUGCGACUACGUGUCCAACAAAGGCGUGGACACCGUGUCUGUGGGCAACACCCUGUACUACGUGAACAAACAAGAGGGCCAGUCUCUGUACGUGAAGGGCGAGCCCAUCAUCAACUUCUACGACCCUCUGGUGUUCCCCAGCGACGAGUUCGAUGCCAGCAUCAGCCAAGUGAACGAGAAGAUCAAUCAGAGCCUGGCCUUCAUCAGAAAGUCCGAUGAGCUGCUGCACAACGUGAACGCCGGCAAGUCCACCACCAAUAUCAUGAUCACGACCAUCAUCAUCGUGAUUAUCGUGAUCCUGCUGUCCCUGAUCGCCGUGGGCCUGCUGCUUUAUUGAUAAUAGGCUGGAGCCUCGGUGGCCAUGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCUUCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
110. YK-RSV-038 DNA, SEQ ID NO: 110
AGCGGCTCGGCCATTTTGTCCCAGTCAGTCCGGAGGCTGCGGCTGCAGAAGTACCGCCTGCGGAGTAACTGCAAAGGCCACCATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCTGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCAGCGCCATTGCCTCTGGTGTCGCCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTGCGTGCTGACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCCTGAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGAGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTACGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCGACGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAGGCTGGAGCCTCGGTGGCCATGCTTCTTGCCCCTTGGGCCTCCCCCCAGCCCCTCCTCCCCTTCCTGCACCCGTACCCCCGTGGTCTTTGAATAAAGTCTGAGTGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
111. YK-RSV-038 ORF NT, SEQ ID NO: 111
ATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCTGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCAGCGCCATTGCCTCTGGTGTCGCCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTGCGTGCTGACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCCTGAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGAGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTACGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCGACGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAG
112. YK-RSV-038 ORF AA, SEQ ID NO: 112
MELLILKANAITTILTAVTFCFASGQNITEEFYQSTCSAVSKGYLGALRTGWYTCVITIELSNIKENKCNGTDAKVKLIKQELDKYKNAVTDLQLLMQSTPATGSGSAIASGVAVSKVLHLEGEVNKIKSALLSTNKAVVSLSNGVCVLTFKVLDLKNYIDKQLLPILNKQSCSIPNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMSIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSRTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEGQSLYVKGEPIINFYDPLVFPSDEFDASISQVNEKINQSLAFIRKSDELLHNVNAGKSTTNIMITTIIIVIIVILLSLIAVGLLLY
113. YK-RSV-038 mRNA, SEQ ID NO: 113
AGCGGCUCGGCCAUUUUGUCCCAGUCAGUCCGGAGGCUGCGGCUGCAGAAGUACCGCCUGCGGAGUAACUGCAAAGGCCACCAUGGAACUGCUGAUCCUGAAGGCCAACGCCAUCACCACCAUCCUGACCGCCGUGACCUUCUGUUUUGCCAGCGGCCAGAACAUCACCGAGGAAUUCUACCAGAGCACCUGUAGCGCCGUGUCCAAGGGAUAUCUGGGCGCCCUUAGAACCGGCUGGUACACCUGCGUGAUCACCAUCGAGCUGAGCAACAUCAAAGAAAACAAGUGCAACGGCACCGACGCCAAAGUGAAGCUGAUCAAGCAAGAGCUGGACAAGUACAAGAAUGCCGUGACCGACCUGCAGCUGCUGAUGCAGUCUACACCAGCCACAGGCUCUGGCAGCGCCAUUGCCUCUGGUGUCGCCGUGUCUAAAGUGCUGCACCUGGAAGGCGAAGUGAACAAGAUCAAGAGCGCCCUGCUGAGCACCAACAAGGCCGUGGUGUCUCUGAGCAAUGGCGUGUGCGUGCUGACCUUCAAGGUGCUGGACCUGAAGAACUACAUCGACAAACAGCUGCUGCCCAUCCUGAACAAGCAGUCCUGCAGCAUCCCCAACAUCGAGACAGUGAUCGAGUUCCAGCAGAAGAACAACCGGCUGCUGGAAAUCACCCGCGAGUUCUCUGUGAAUGCCGGCGUGACCACACCUGUGUCCACCUACAUGCUGACCAACAGCGAGCUGCUGAGCCUGAUCAACGACAUGCCCAUCACCAACGACCAGAAAAAGCUGAUGAGCAACAACGUGCAGAUCGUGCGGCAGCAGAGCUACAGCAUCAUGAGCAUUAUCAAAGAAGAGGUGCUGGCCUACGUGGUGCAGCUGCCUCUGUAUGGCGUGAUCGAUACCCCUUGCUGGAAGCUGCACACAAGCCCUCUGUGCACCACCAACACCAAAGAGGGCAGCAACAUCUGCCUGACCAGAACCGACAGAGGCUGGUACUGCGAUAAUGCCGGCAGCGUCUCAUUCUUCCCACAAGCCGAGACAUGCAAGGUGCAGAGCAACCGGGUGUUCUGCGACACCAUGAAUAGCAGAACCCUGCCUUCCGAAGUGAAUCUGUGCAACGUGGACAUCUUCAACCCUAAGUACGACUGCAAGAUCAUGACCAGCAAGACCGACGUGUCCAGCAGUGUGAUCACCUCACUGGGCGCCAUCGUGUCCUGUUACGGCAAGACCAAGUGCACCGCCAGCAACAAGAACCGGGGCAUCAUCAAGACCUUCAGCAACGGCUGCGACUACGUGUCCAACAAAGGCGUGGACACCGUGUCUGUGGGCAACACCCUGUACUACGUGAACAAACAAGAGGGCCAGUCUCUGUACGUGAAGGGCGAGCCCAUCAUCAACUUCUACGACCCUCUGGUGUUCCCCAGCGACGAGUUCGAUGCCAGCAUCAGCCAAGUGAACGAGAAGAUCAAUCAGAGCCUGGCCUUCAUCAGAAAGUCCGAUGAGCUGCUGCACAACGUGAACGCCGGCAAGUCCACCACCAAUAUCAUGAUCACGACCAUCAUCAUCGUGAUUAUCGUGAUCCUGCUGUCCCUGAUCGCCGUGGGCCUGCUGCUUUAUUGAUAAUAGGCUGGAGCCUCGGUGGCCAUGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCUUCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
114. YK-RSV-039 DNA, SEQ ID NO: 114
AGCGGCTCGGCCATTTTGTCCCAGTCAGTCCGGAGGCTGCGGCTGCAGAAGTACCGCCTGCGGAGTAACTGCAAAGGCCACCATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACTGCAGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCAGCGCCATTGCCTCTGGTTGCGCCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCCTGAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGAGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTACGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCGACGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAGGCTGGAGCCTCGGTGGCCATGCTTCTTGCCCCTTGGGCCTCCCCCCAGCCCCTCCTCCCCTTCCTGCACCCGTACCCCCGTGGTCTTTGAATAAAGTCTGAGTGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
115. YK-RSV-039 ORF NT, SEQ ID NO: 115
ATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACTGCAGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCAGCGCCATTGCCTCTGGTTGCGCCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCCTGAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGAGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTACGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCGACGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAG
116. YK-RSV-039 ORF AA, SEQ ID NO: 116
MELLILKANAITTILTAVTFCFASGQNITEEFYQSTCSAVSKGYLGALRTGWYCSVITIELSNIKENKCNGTDAKVKLIKQELDKYKNAVTDLQLLMQSTPATGSGSAIASGCAVSKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTFKVLDLKNYIDKQLLPILNKQSCSIPNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMSIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSRTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEGQSLYVKGEPIINFYDPLVFPSDEFDASISQVNEKINQSLAFIRKSDELLHNVNAGKSTTNIMITTIIIVIIVILLSLIAVGLLLY
117. YK-RSV-039 mRNA, SEQ ID NO: 117
AGCGGCUCGGCCAUUUUGUCCCAGUCAGUCCGGAGGCUGCGGCUGCAGAAGUACCGCCUGCGGAGUAACUGCAAAGGCCACCAUGGAACUGCUGAUCCUGAAGGCCAACGCCAUCACCACCAUCCUGACCGCCGUGACCUUCUGUUUUGCCAGCGGCCAGAACAUCACCGAGGAAUUCUACCAGAGCACCUGUAGCGCCGUGUCCAAGGGAUAUCUGGGCGCCCUUAGAACCGGCUGGUACUGCAGCGUGAUCACCAUCGAGCUGAGCAACAUCAAAGAAAACAAGUGCAACGGCACCGACGCCAAAGUGAAGCUGAUCAAGCAAGAGCUGGACAAGUACAAGAAUGCCGUGACCGACCUGCAGCUGCUGAUGCAGUCUACACCAGCCACAGGCUCUGGCAGCGCCAUUGCCUCUGGUUGCGCCGUGUCUAAAGUGCUGCACCUGGAAGGCGAAGUGAACAAGAUCAAGAGCGCCCUGCUGAGCACCAACAAGGCCGUGGUGUCUCUGAGCAAUGGCGUGUCCGUGCUGACCUUCAAGGUGCUGGACCUGAAGAACUACAUCGACAAACAGCUGCUGCCCAUCCUGAACAAGCAGUCCUGCAGCAUCCCCAACAUCGAGACAGUGAUCGAGUUCCAGCAGAAGAACAACCGGCUGCUGGAAAUCACCCGCGAGUUCUCUGUGAAUGCCGGCGUGACCACACCUGUGUCCACCUACAUGCUGACCAACAGCGAGCUGCUGAGCCUGAUCAACGACAUGCCCAUCACCAACGACCAGAAAAAGCUGAUGAGCAACAACGUGCAGAUCGUGCGGCAGCAGAGCUACAGCAUCAUGAGCAUUAUCAAAGAAGAGGUGCUGGCCUACGUGGUGCAGCUGCCUCUGUAUGGCGUGAUCGAUACCCCUUGCUGGAAGCUGCACACAAGCCCUCUGUGCACCACCAACACCAAAGAGGGCAGCAACAUCUGCCUGACCAGAACCGACAGAGGCUGGUACUGCGAUAAUGCCGGCAGCGUCUCAUUCUUCCCACAAGCCGAGACAUGCAAGGUGCAGAGCAACCGGGUGUUCUGCGACACCAUGAAUAGCAGAACCCUGCCUUCCGAAGUGAAUCUGUGCAACGUGGACAUCUUCAACCCUAAGUACGACUGCAAGAUCAUGACCAGCAAGACCGACGUGUCCAGCAGUGUGAUCACCUCACUGGGCGCCAUCGUGUCCUGUUACGGCAAGACCAAGUGCACCGCCAGCAACAAGAACCGGGGCAUCAUCAAGACCUUCAGCAACGGCUGCGACUACGUGUCCAACAAAGGCGUGGACACCGUGUCUGUGGGCAACACCCUGUACUACGUGAACAAACAAGAGGGCCAGUCUCUGUACGUGAAGGGCGAGCCCAUCAUCAACUUCUACGACCCUCUGGUGUUCCCCAGCGACGAGUUCGAUGCCAGCAUCAGCCAAGUGAACGAGAAGAUCAAUCAGAGCCUGGCCUUCAUCAGAAAGUCCGAUGAGCUGCUGCACAACGUGAACGCCGGCAAGUCCACCACCAAUAUCAUGAUCACGACCAUCAUCAUCGUGAUUAUCGUGAUCCUGCUGUCCCUGAUCGCCGUGGGCCUGCUGCUUUAUUGAUAAUAGGCUGGAGCCUCGGUGGCCAUGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCUUCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
118. YK-RSV-040 DNA, SEQ ID NO: 118
AGCGGCTCGGCCATTTTGTCCCAGTCAGTCCGGAGGCTGCGGCTGCAGAAGTACCGCCTGCGGAGTAACTGCAAAGGCCACCATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACTGCAGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCAGCGCCATTGCCTCTGGTGTCTGCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCCTGAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGAGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTACGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCGACGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAGGCTGGAGCCTCGGTGGCCATGCTTCTTGCCCCTTGGGCCTCCCCCCAGCCCCTCCTCCCCTTCCTGCACCCGTACCCCCGTGGTCTTTGAATAAAGTCTGAGTGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
119. YK-RSV-040 ORF NT, SEQ ID NO: 119
ATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACTGCAGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCAGCGCCATTGCCTCTGGTGTCTGCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCCTGAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGAGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTACGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCGACGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAG
120. YK-RSV-040 ORF AA, SEQ ID NO: 120
MELLILKANAITTILTAVTFCFASGQNITEEFYQSTCSAVSKGYLGALRTGWYCSVITIELSNIKENKCNGTDAKVKLIKQELDKYKNAVTDLQLLMQSTPATGSGSAIASGVCVSKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTFKVLDLKNYIDKQLLPILNKQSCSIPNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMSIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSRTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEGQSLYVKGEPIINFYDPLVFPSDEFDASISQVNEKINQSLAFIRKSDELLHNVNAGKSTTNIMITTIIIVIIVILLSLIAVGLLLY
121. YK-RSV-040 mRNA, SEQ ID NO: 121
AGCGGCUCGGCCAUUUUGUCCCAGUCAGUCCGGAGGCUGCGGCUGCAGAAGUACCGCCUGCGGAGUAACUGCAAAGGCCACCAUGGAACUGCUGAUCCUGAAGGCCAACGCCAUCACCACCAUCCUGACCGCCGUGACCUUCUGUUUUGCCAGCGGCCAGAACAUCACCGAGGAAUUCUACCAGAGCACCUGUAGCGCCGUGUCCAAGGGAUAUCUGGGCGCCCUUAGAACCGGCUGGUACUGCAGCGUGAUCACCAUCGAGCUGAGCAACAUCAAAGAAAACAAGUGCAACGGCACCGACGCCAAAGUGAAGCUGAUCAAGCAAGAGCUGGACAAGUACAAGAAUGCCGUGACCGACCUGCAGCUGCUGAUGCAGUCUACACCAGCCACAGGCUCUGGCAGCGCCAUUGCCUCUGGUGUCUGCGUGUCUAAAGUGCUGCACCUGGAAGGCGAAGUGAACAAGAUCAAGAGCGCCCUGCUGAGCACCAACAAGGCCGUGGUGUCUCUGAGCAAUGGCGUGUCCGUGCUGACCUUCAAGGUGCUGGACCUGAAGAACUACAUCGACAAACAGCUGCUGCCCAUCCUGAACAAGCAGUCCUGCAGCAUCCCCAACAUCGAGACAGUGAUCGAGUUCCAGCAGAAGAACAACCGGCUGCUGGAAAUCACCCGCGAGUUCUCUGUGAAUGCCGGCGUGACCACACCUGUGUCCACCUACAUGCUGACCAACAGCGAGCUGCUGAGCCUGAUCAACGACAUGCCCAUCACCAACGACCAGAAAAAGCUGAUGAGCAACAACGUGCAGAUCGUGCGGCAGCAGAGCUACAGCAUCAUGAGCAUUAUCAAAGAAGAGGUGCUGGCCUACGUGGUGCAGCUGCCUCUGUAUGGCGUGAUCGAUACCCCUUGCUGGAAGCUGCACACAAGCCCUCUGUGCACCACCAACACCAAAGAGGGCAGCAACAUCUGCCUGACCAGAACCGACAGAGGCUGGUACUGCGAUAAUGCCGGCAGCGUCUCAUUCUUCCCACAAGCCGAGACAUGCAAGGUGCAGAGCAACCGGGUGUUCUGCGACACCAUGAAUAGCAGAACCCUGCCUUCCGAAGUGAAUCUGUGCAACGUGGACAUCUUCAACCCUAAGUACGACUGCAAGAUCAUGACCAGCAAGACCGACGUGUCCAGCAGUGUGAUCACCUCACUGGGCGCCAUCGUGUCCUGUUACGGCAAGACCAAGUGCACCGCCAGCAACAAGAACCGGGGCAUCAUCAAGACCUUCAGCAACGGCUGCGACUACGUGUCCAACAAAGGCGUGGACACCGUGUCUGUGGGCAACACCCUGUACUACGUGAACAAACAAGAGGGCCAGUCUCUGUACGUGAAGGGCGAGCCCAUCAUCAACUUCUACGACCCUCUGGUGUUCCCCAGCGACGAGUUCGAUGCCAGCAUCAGCCAAGUGAACGAGAAGAUCAAUCAGAGCCUGGCCUUCAUCAGAAAGUCCGAUGAGCUGCUGCACAACGUGAACGCCGGCAAGUCCACCACCAAUAUCAUGAUCACGACCAUCAUCAUCGUGAUUAUCGUGAUCCUGCUGUCCCUGAUCGCCGUGGGCCUGCUGCUUUAUUGAUAAUAGGCUGGAGCCUCGGUGGCCAUGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCUUCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
122. YK-RSV-041 DNA, SEQ ID NO: 122
AGCGGCTCGGCCATTTTGTCCCAGTCAGTCCGGAGGCTGCGGCTGCAGAAGTACCGCCTGCGGAGTAACTGCAAAGGCCACCATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGTGCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCAGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCAGCGCCATTGCCTCTGGTGTCGCCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCCTGAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGAGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACATGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTACGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCGACGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAGGCTGGAGCCTCGGTGGCCATGCTTCTTGCCCCTTGGGCCTCCCCCCAGCCCCTCCTCCCCTTCCTGCACCCGTACCCCCGTGGTCTTTGAATAAAGTCTGAGTGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
123. YK-RSV-041 ORF NT, SEQ ID NO: 123
ATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGTGCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCAGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCAGCGCCATTGCCTCTGGTGTCGCCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCCTGAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGAGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACATGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTACGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCGACGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAG
124. YK-RSV-041 ORF AA, SEQ ID NO: 124
MELLILKANAITTILTAVTFCFASGQNITEEFYQSTCSAVCKGYLGALRTGWYTSVITIELSNIKENKCNGTDAKVKLIKQELDKYKNAVTDLQLLMQSTPATGSGSAIASGVAVSKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTFKVLDLKNYIDKQLLPILNKQSCSIPNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMSIIKEEVLAYVVQLPLYGVIDTPCWKLHTCPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSRTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEGQSLYVKGEPIINFYDPLVFPSDEFDASISQVNEKINQSLAFIRKSDELLHNVNAGKSTTNIMITTIIIVIIVILLSLIAVGLLLY
125. YK-RSV-041 mRNA, SEQ ID NO: 125
AGCGGCUCGGCCAUUUUGUCCCAGUCAGUCCGGAGGCUGCGGCUGCAGAAGUACCGCCUGCGGAGUAACUGCAAAGGCCACCAUGGAACUGCUGAUCCUGAAGGCCAACGCCAUCACCACCAUCCUGACCGCCGUGACCUUCUGUUUUGCCAGCGGCCAGAACAUCACCGAGGAAUUCUACCAGAGCACCUGUAGCGCCGUGUGCAAGGGAUAUCUGGGCGCCCUUAGAACCGGCUGGUACACCAGCGUGAUCACCAUCGAGCUGAGCAACAUCAAAGAAAACAAGUGCAACGGCACCGACGCCAAAGUGAAGCUGAUCAAGCAAGAGCUGGACAAGUACAAGAAUGCCGUGACCGACCUGCAGCUGCUGAUGCAGUCUACACCAGCCACAGGCUCUGGCAGCGCCAUUGCCUCUGGUGUCGCCGUGUCUAAAGUGCUGCACCUGGAAGGCGAAGUGAACAAGAUCAAGAGCGCCCUGCUGAGCACCAACAAGGCCGUGGUGUCUCUGAGCAAUGGCGUGUCCGUGCUGACCUUCAAGGUGCUGGACCUGAAGAACUACAUCGACAAACAGCUGCUGCCCAUCCUGAACAAGCAGUCCUGCAGCAUCCCCAACAUCGAGACAGUGAUCGAGUUCCAGCAGAAGAACAACCGGCUGCUGGAAAUCACCCGCGAGUUCUCUGUGAAUGCCGGCGUGACCACACCUGUGUCCACCUACAUGCUGACCAACAGCGAGCUGCUGAGCCUGAUCAACGACAUGCCCAUCACCAACGACCAGAAAAAGCUGAUGAGCAACAACGUGCAGAUCGUGCGGCAGCAGAGCUACAGCAUCAUGAGCAUUAUCAAAGAAGAGGUGCUGGCCUACGUGGUGCAGCUGCCUCUGUAUGGCGUGAUCGAUACCCCUUGCUGGAAGCUGCACACAUGCCCUCUGUGCACCACCAACACCAAAGAGGGCAGCAACAUCUGCCUGACCAGAACCGACAGAGGCUGGUACUGCGAUAAUGCCGGCAGCGUCUCAUUCUUCCCACAAGCCGAGACAUGCAAGGUGCAGAGCAACCGGGUGUUCUGCGACACCAUGAAUAGCAGAACCCUGCCUUCCGAAGUGAAUCUGUGCAACGUGGACAUCUUCAACCCUAAGUACGACUGCAAGAUCAUGACCAGCAAGACCGACGUGUCCAGCAGUGUGAUCACCUCACUGGGCGCCAUCGUGUCCUGUUACGGCAAGACCAAGUGCACCGCCAGCAACAAGAACCGGGGCAUCAUCAAGACCUUCAGCAACGGCUGCGACUACGUGUCCAACAAAGGCGUGGACACCGUGUCUGUGGGCAACACCCUGUACUACGUGAACAAACAAGAGGGCCAGUCUCUGUACGUGAAGGGCGAGCCCAUCAUCAACUUCUACGACCCUCUGGUGUUCCCCAGCGACGAGUUCGAUGCCAGCAUCAGCCAAGUGAACGAGAAGAUCAAUCAGAGCCUGGCCUUCAUCAGAAAGUCCGAUGAGCUGCUGCACAACGUGAACGCCGGCAAGUCCACCACCAAUAUCAUGAUCACGACCAUCAUCAUCGUGAUUAUCGUGAUCCUGCUGUCCCUGAUCGCCGUGGGCCUGCUGCUUUAUUGAUAAUAGGCUGGAGCCUCGGUGGCCAUGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCUUCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
126. YK-RSV-042 DNA, SEQ ID NO: 126
AGCGGCTCGGCCATTTTGTCCCAGTCAGTCCGGAGGCTGCGGCTGCAGAAGTACCGCCTGCGGAGTAACTGCAAAGGCCACCATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATGCCTGGGCGCCCTTAGAACCGGCTGGTACACCAGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCAGCGCCATTGCCTCTGGTGTCGCCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCCTGAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGAGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACATGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTACGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCGACGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAGGCTGGAGCCTCGGTGGCCATGCTTCTTGCCCCTTGGGCCTCCCCCCAGCCCCTCCTCCCCTTCCTGCACCCGTACCCCCGTGGTCTTTGAATAAAGTCTGAGTGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
127. YK-RSV-042 ORF NT, SEQ ID NO: 127
ATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATGCCTGGGCGCCCTTAGAACCGGCTGGTACACCAGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCAGCGCCATTGCCTCTGGTGTCGCCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCCTGAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGAGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACATGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTACGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCGACGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAG
128. YK-RSV-042 ORF AA, SEQ ID NO: 128
MELLILKANAITTILTAVTFCFASGQNITEEFYQSTCSAVSKGCLGALRTGWYTSVITIELSNIKENKCNGTDAKVKLIKQELDKYKNAVTDLQLLMQSTPATGSGSAIASGVAVSKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTFKVLDLKNYIDKQLLPILNKQSCSIPNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMSIIKEEVLAYVVQLPLYGVIDTPCWKLHTCPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSRTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEGQSLYVKGEPIINFYDPLVFPSDEFDASISQVNEKINQSLAFIRKSDELLHNVNAGKSTTNIMITTIIIVIIVILLSLIAVGLLLY
129. YK-RSV-042 mRNA, SEQ ID NO: 129
AGCGGCUCGGCCAUUUUGUCCCAGUCAGUCCGGAGGCUGCGGCUGCAGAAGUACCGCCUGCGGAGUAACUGCAAAGGCCACCAUGGAACUGCUGAUCCUGAAGGCCAACGCCAUCACCACCAUCCUGACCGCCGUGACCUUCUGUUUUGCCAGCGGCCAGAACAUCACCGAGGAAUUCUACCAGAGCACCUGUAGCGCCGUGUCCAAGGGAUGCCUGGGCGCCCUUAGAACCGGCUGGUACACCAGCGUGAUCACCAUCGAGCUGAGCAACAUCAAAGAAAACAAGUGCAACGGCACCGACGCCAAAGUGAAGCUGAUCAAGCAAGAGCUGGACAAGUACAAGAAUGCCGUGACCGACCUGCAGCUGCUGAUGCAGUCUACACCAGCCACAGGCUCUGGCAGCGCCAUUGCCUCUGGUGUCGCCGUGUCUAAAGUGCUGCACCUGGAAGGCGAAGUGAACAAGAUCAAGAGCGCCCUGCUGAGCACCAACAAGGCCGUGGUGUCUCUGAGCAAUGGCGUGUCCGUGCUGACCUUCAAGGUGCUGGACCUGAAGAACUACAUCGACAAACAGCUGCUGCCCAUCCUGAACAAGCAGUCCUGCAGCAUCCCCAACAUCGAGACAGUGAUCGAGUUCCAGCAGAAGAACAACCGGCUGCUGGAAAUCACCCGCGAGUUCUCUGUGAAUGCCGGCGUGACCACACCUGUGUCCACCUACAUGCUGACCAACAGCGAGCUGCUGAGCCUGAUCAACGACAUGCCCAUCACCAACGACCAGAAAAAGCUGAUGAGCAACAACGUGCAGAUCGUGCGGCAGCAGAGCUACAGCAUCAUGAGCAUUAUCAAAGAAGAGGUGCUGGCCUACGUGGUGCAGCUGCCUCUGUAUGGCGUGAUCGAUACCCCUUGCUGGAAGCUGCACACAUGCCCUCUGUGCACCACCAACACCAAAGAGGGCAGCAACAUCUGCCUGACCAGAACCGACAGAGGCUGGUACUGCGAUAAUGCCGGCAGCGUCUCAUUCUUCCCACAAGCCGAGACAUGCAAGGUGCAGAGCAACCGGGUGUUCUGCGACACCAUGAAUAGCAGAACCCUGCCUUCCGAAGUGAAUCUGUGCAACGUGGACAUCUUCAACCCUAAGUACGACUGCAAGAUCAUGACCAGCAAGACCGACGUGUCCAGCAGUGUGAUCACCUCACUGGGCGCCAUCGUGUCCUGUUACGGCAAGACCAAGUGCACCGCCAGCAACAAGAACCGGGGCAUCAUCAAGACCUUCAGCAACGGCUGCGACUACGUGUCCAACAAAGGCGUGGACACCGUGUCUGUGGGCAACACCCUGUACUACGUGAACAAACAAGAGGGCCAGUCUCUGUACGUGAAGGGCGAGCCCAUCAUCAACUUCUACGACCCUCUGGUGUUCCCCAGCGACGAGUUCGAUGCCAGCAUCAGCCAAGUGAACGAGAAGAUCAAUCAGAGCCUGGCCUUCAUCAGAAAGUCCGAUGAGCUGCUGCACAACGUGAACGCCGGCAAGUCCACCACCAAUAUCAUGAUCACGACCAUCAUCAUCGUGAUUAUCGUGAUCCUGCUGUCCCUGAUCGCCGUGGGCCUGCUGCUUUAUUGAUAAUAGGCUGGAGCCUCGGUGGCCAUGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCUUCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
130. YK-RSV-043 DNA, SEQ ID NO: 130
AGCGGCTCGGCCATTTTGTCCCAGTCAGTCCGGAGGCTGCGGCTGCAGAAGTACCGCCTGCGGAGTAACTGCAAAGGCCACCATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCAGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTTGCCCAGCCACAGGCTCTGGCAGCGCCATTGCCTGCGGTGTCGCCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCCTGAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGAGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTACGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCGACGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAGGCTGGAGCCTCGGTGGCCATGCTTCTTGCCCCTTGGGCCTCCCCCCAGCCCCTCCTCCCCTTCCTGCACCCGTACCCCCGTGGTCTTTGAATAAAGTCTGAGTGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
131. YK-RSV-043 ORF NT, SEQ ID NO: 131
ATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCAGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTTGCCCAGCCACAGGCTCTGGCAGCGCCATTGCCTGCGGTGTCGCCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCCTGAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGAGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTACGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCGACGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAG
132. YK-RSV-043 ORF AA, SEQ ID NO: 132
MELLILKANAITTILTAVTFCFASGQNITEEFYQSTCSAVSKGYLGALRTGWYTSVITIELSNIKENKCNGTDAKVKLIKQELDKYKNAVTDLQLLMQSCPATGSGSAIACGVAVSKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTFKVLDLKNYIDKQLLPILNKQSCSIPNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMSIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSRTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEGQSLYVKGEPIINFYDPLVFPSDEFDASISQVNEKINQSLAFIRKSDELLHNVNAGKSTTNIMITTIIIVIIVILLSLIAVGLLLY
133. YK-RSV-043 mRNA, SEQ ID NO: 133
AGCGGCUCGGCCAUUUUGUCCCAGUCAGUCCGGAGGCUGCGGCUGCAGAAGUACCGCCUGCGGAGUAACUGCAAAGGCCACCAUGGAACUGCUGAUCCUGAAGGCCAACGCCAUCACCACCAUCCUGACCGCCGUGACCUUCUGUUUUGCCAGCGGCCAGAACAUCACCGAGGAAUUCUACCAGAGCACCUGUAGCGCCGUGUCCAAGGGAUAUCUGGGCGCCCUUAGAACCGGCUGGUACACCAGCGUGAUCACCAUCGAGCUGAGCAACAUCAAAGAAAACAAGUGCAACGGCACCGACGCCAAAGUGAAGCUGAUCAAGCAAGAGCUGGACAAGUACAAGAAUGCCGUGACCGACCUGCAGCUGCUGAUGCAGUCUUGCCCAGCCACAGGCUCUGGCAGCGCCAUUGCCUGCGGUGUCGCCGUGUCUAAAGUGCUGCACCUGGAAGGCGAAGUGAACAAGAUCAAGAGCGCCCUGCUGAGCACCAACAAGGCCGUGGUGUCUCUGAGCAAUGGCGUGUCCGUGCUGACCUUCAAGGUGCUGGACCUGAAGAACUACAUCGACAAACAGCUGCUGCCCAUCCUGAACAAGCAGUCCUGCAGCAUCCCCAACAUCGAGACAGUGAUCGAGUUCCAGCAGAAGAACAACCGGCUGCUGGAAAUCACCCGCGAGUUCUCUGUGAAUGCCGGCGUGACCACACCUGUGUCCACCUACAUGCUGACCAACAGCGAGCUGCUGAGCCUGAUCAACGACAUGCCCAUCACCAACGACCAGAAAAAGCUGAUGAGCAACAACGUGCAGAUCGUGCGGCAGCAGAGCUACAGCAUCAUGAGCAUUAUCAAAGAAGAGGUGCUGGCCUACGUGGUGCAGCUGCCUCUGUAUGGCGUGAUCGAUACCCCUUGCUGGAAGCUGCACACAAGCCCUCUGUGCACCACCAACACCAAAGAGGGCAGCAACAUCUGCCUGACCAGAACCGACAGAGGCUGGUACUGCGAUAAUGCCGGCAGCGUCUCAUUCUUCCCACAAGCCGAGACAUGCAAGGUGCAGAGCAACCGGGUGUUCUGCGACACCAUGAAUAGCAGAACCCUGCCUUCCGAAGUGAAUCUGUGCAACGUGGACAUCUUCAACCCUAAGUACGACUGCAAGAUCAUGACCAGCAAGACCGACGUGUCCAGCAGUGUGAUCACCUCACUGGGCGCCAUCGUGUCCUGUUACGGCAAGACCAAGUGCACCGCCAGCAACAAGAACCGGGGCAUCAUCAAGACCUUCAGCAACGGCUGCGACUACGUGUCCAACAAAGGCGUGGACACCGUGUCUGUGGGCAACACCCUGUACUACGUGAACAAACAAGAGGGCCAGUCUCUGUACGUGAAGGGCGAGCCCAUCAUCAACUUCUACGACCCUCUGGUGUUCCCCAGCGACGAGUUCGAUGCCAGCAUCAGCCAAGUGAACGAGAAGAUCAAUCAGAGCCUGGCCUUCAUCAGAAAGUCCGAUGAGCUGCUGCACAACGUGAACGCCGGCAAGUCCACCACCAAUAUCAUGAUCACGACCAUCAUCAUCGUGAUUAUCGUGAUCCUGCUGUCCCUGAUCGCCGUGGGCCUGCUGCUUUAUUGAUAAUAGGCUGGAGCCUCGGUGGCCAUGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCUUCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
134. YK-RSV-044 DNA, SEQ ID NO: 134
AGCGGCTCGGCCATTTTGTCCCAGTCAGTCCGGAGGCTGCGGCTGCAGAAGTACCGCCTGCGGAGTAACTGCAAAGGCCACCATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCAGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTTGCCCAGCCACAGGCTCTGGCAGCGCCATTTGCTCTGGTGTCGCCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCCTGAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGAGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTACGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCGACGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAGGCTGGAGCCTCGGTGGCCATGCTTCTTGCCCCTTGGGCCTCCCCCCAGCCCCTCCTCCCCTTCCTGCACCCGTACCCCCGTGGTCTTTGAATAAAGTCTGAGTGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
135. YK-RSV-044 ORF NT, SEQ ID NO: 135
ATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCAGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTTGCCCAGCCACAGGCTCTGGCAGCGCCATTTGCTCTGGTGTCGCCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCCTGAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGAGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTACGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCGACGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAG
136. YK-RSV-044 ORF AA, SEQ ID NO: 136
MELLILKANAITTILTAVTFCFASGQNITEEFYQSTCSAVSKGYLGALRTGWYTSVITIELSNIKENKCNGTDAKVKLIKQELDKYKNAVTDLQLLMQSCPATGSGSAICSGVAVSKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTFKVLDLKNYIDKQLLPILNKQSCSIPNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMSIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSRTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEGQSLYVKGEPIINFYDPLVFPSDEFDASISQVNEKINQSLAFIRKSDELLHNVNAGKSTTNIMITTIIIVIIVILLSLIAVGLLLY
137. YK-RSV-044 mRNA, SEQ ID NO: 137
AGCGGCUCGGCCAUUUUGUCCCAGUCAGUCCGGAGGCUGCGGCUGCAGAAGUACCGCCUGCGGAGUAACUGCAAAGGCCACCAUGGAACUGCUGAUCCUGAAGGCCAACGCCAUCACCACCAUCCUGACCGCCGUGACCUUCUGUUUUGCCAGCGGCCAGAACAUCACCGAGGAAUUCUACCAGAGCACCUGUAGCGCCGUGUCCAAGGGAUAUCUGGGCGCCCUUAGAACCGGCUGGUACACCAGCGUGAUCACCAUCGAGCUGAGCAACAUCAAAGAAAACAAGUGCAACGGCACCGACGCCAAAGUGAAGCUGAUCAAGCAAGAGCUGGACAAGUACAAGAAUGCCGUGACCGACCUGCAGCUGCUGAUGCAGUCUUGCCCAGCCACAGGCUCUGGCAGCGCCAUUUGCUCUGGUGUCGCCGUGUCUAAAGUGCUGCACCUGGAAGGCGAAGUGAACAAGAUCAAGAGCGCCCUGCUGAGCACCAACAAGGCCGUGGUGUCUCUGAGCAAUGGCGUGUCCGUGCUGACCUUCAAGGUGCUGGACCUGAAGAACUACAUCGACAAACAGCUGCUGCCCAUCCUGAACAAGCAGUCCUGCAGCAUCCCCAACAUCGAGACAGUGAUCGAGUUCCAGCAGAAGAACAACCGGCUGCUGGAAAUCACCCGCGAGUUCUCUGUGAAUGCCGGCGUGACCACACCUGUGUCCACCUACAUGCUGACCAACAGCGAGCUGCUGAGCCUGAUCAACGACAUGCCCAUCACCAACGACCAGAAAAAGCUGAUGAGCAACAACGUGCAGAUCGUGCGGCAGCAGAGCUACAGCAUCAUGAGCAUUAUCAAAGAAGAGGUGCUGGCCUACGUGGUGCAGCUGCCUCUGUAUGGCGUGAUCGAUACCCCUUGCUGGAAGCUGCACACAAGCCCUCUGUGCACCACCAACACCAAAGAGGGCAGCAACAUCUGCCUGACCAGAACCGACAGAGGCUGGUACUGCGAUAAUGCCGGCAGCGUCUCAUUCUUCCCACAAGCCGAGACAUGCAAGGUGCAGAGCAACCGGGUGUUCUGCGACACCAUGAAUAGCAGAACCCUGCCUUCCGAAGUGAAUCUGUGCAACGUGGACAUCUUCAACCCUAAGUACGACUGCAAGAUCAUGACCAGCAAGACCGACGUGUCCAGCAGUGUGAUCACCUCACUGGGCGCCAUCGUGUCCUGUUACGGCAAGACCAAGUGCACCGCCAGCAACAAGAACCGGGGCAUCAUCAAGACCUUCAGCAACGGCUGCGACUACGUGUCCAACAAAGGCGUGGACACCGUGUCUGUGGGCAACACCCUGUACUACGUGAACAAACAAGAGGGCCAGUCUCUGUACGUGAAGGGCGAGCCCAUCAUCAACUUCUACGACCCUCUGGUGUUCCCCAGCGACGAGUUCGAUGCCAGCAUCAGCCAAGUGAACGAGAAGAUCAAUCAGAGCCUGGCCUUCAUCAGAAAGUCCGAUGAGCUGCUGCACAACGUGAACGCCGGCAAGUCCACCACCAAUAUCAUGAUCACGACCAUCAUCAUCGUGAUUAUCGUGAUCCUGCUGUCCCUGAUCGCCGUGGGCCUGCUGCUUUAUUGAUAAUAGGCUGGAGCCUCGGUGGCCAUGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCUUCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
138. YK-RSV-045 DNA, SEQ ID NO: 138
AGCGGCTCGGCCATTTTGTCCCAGTCAGTCCGGAGGCTGCGGCTGCAGAAGTACCGCCTGCGGAGTAACTGCAAAGGCCACCATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCAGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTTGCCCAGCCACAGGCTCTGGCAGCGCCATTGCCTCTGGTGTCGCCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCCTGAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGAGCATTATCAAAGAAGAGGTGCTGGCCTACTGCGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTACGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCGACGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAGGCTGGAGCCTCGGTGGCCATGCTTCTTGCCCCTTGGGCCTCCCCCCAGCCCCTCCTCCCCTTCCTGCACCCGTACCCCCGTGGTCTTTGAATAAAGTCTGAGTGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
139. YK-RSV-045 ORF NT, SEQ ID NO:139
ATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCAGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTTGCCCAGCCACAGGCTCTGGCAGCGCCATTGCCTCTGGTGTCGCCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCCTGAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGAGCATTATCAAAGAAGAGGTGCTGGCCTACTGCGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTACGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCGACGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAG
140. YK-RSV-045 ORF AA, SEQ ID NO: 140
MELLILKANAITTILTAVTFCFASGQNITEEFYQSTCSAVSKGYLGALRTGWYTSVITIELSNIKENKCNGTDAKVKLIKQELDKYKNAVTDLQLLMQSCPATGSGSAIASGVAVSKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTFKVLDLKNYIDKQLLPILNKQSCSIPNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMSIIKEEVLAYCVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSRTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEGQSLYVKGEPIINFYDPLVFPSDEFDASISQVNEKINQSLAFIRKSDELLHNVNAGKSTTNIMITTIIIVIIVILLSLIAVGLLLY
141. YK-RSV-045 mRNA, SEQ ID NO: 141
AGCGGCUCGGCCAUUUUGUCCCAGUCAGUCCGGAGGCUGCGGCUGCAGAAGUACCGCCUGCGGAGUAACUGCAAAGGCCACCAUGGAACUGCUGAUCCUGAAGGCCAACGCCAUCACCACCAUCCUGACCGCCGUGACCUUCUGUUUUGCCAGCGGCCAGAACAUCACCGAGGAAUUCUACCAGAGCACCUGUAGCGCCGUGUCCAAGGGAUAUCUGGGCGCCCUUAGAACCGGCUGGUACACCAGCGUGAUCACCAUCGAGCUGAGCAACAUCAAAGAAAACAAGUGCAACGGCACCGACGCCAAAGUGAAGCUGAUCAAGCAAGAGCUGGACAAGUACAAGAAUGCCGUGACCGACCUGCAGCUGCUGAUGCAGUCUUGCCCAGCCACAGGCUCUGGCAGCGCCAUUGCCUCUGGUGUCGCCGUGUCUAAAGUGCUGCACCUGGAAGGCGAAGUGAACAAGAUCAAGAGCGCCCUGCUGAGCACCAACAAGGCCGUGGUGUCUCUGAGCAAUGGCGUGUCCGUGCUGACCUUCAAGGUGCUGGACCUGAAGAACUACAUCGACAAACAGCUGCUGCCCAUCCUGAACAAGCAGUCCUGCAGCAUCCCCAACAUCGAGACAGUGAUCGAGUUCCAGCAGAAGAACAACCGGCUGCUGGAAAUCACCCGCGAGUUCUCUGUGAAUGCCGGCGUGACCACACCUGUGUCCACCUACAUGCUGACCAACAGCGAGCUGCUGAGCCUGAUCAACGACAUGCCCAUCACCAACGACCAGAAAAAGCUGAUGAGCAACAACGUGCAGAUCGUGCGGCAGCAGAGCUACAGCAUCAUGAGCAUUAUCAAAGAAGAGGUGCUGGCCUACUGCGUGCAGCUGCCUCUGUAUGGCGUGAUCGAUACCCCUUGCUGGAAGCUGCACACAAGCCCUCUGUGCACCACCAACACCAAAGAGGGCAGCAACAUCUGCCUGACCAGAACCGACAGAGGCUGGUACUGCGAUAAUGCCGGCAGCGUCUCAUUCUUCCCACAAGCCGAGACAUGCAAGGUGCAGAGCAACCGGGUGUUCUGCGACACCAUGAAUAGCAGAACCCUGCCUUCCGAAGUGAAUCUGUGCAACGUGGACAUCUUCAACCCUAAGUACGACUGCAAGAUCAUGACCAGCAAGACCGACGUGUCCAGCAGUGUGAUCACCUCACUGGGCGCCAUCGUGUCCUGUUACGGCAAGACCAAGUGCACCGCCAGCAACAAGAACCGGGGCAUCAUCAAGACCUUCAGCAACGGCUGCGACUACGUGUCCAACAAAGGCGUGGACACCGUGUCUGUGGGCAACACCCUGUACUACGUGAACAAACAAGAGGGCCAGUCUCUGUACGUGAAGGGCGAGCCCAUCAUCAACUUCUACGACCCUCUGGUGUUCCCCAGCGACGAGUUCGAUGCCAGCAUCAGCCAAGUGAACGAGAAGAUCAAUCAGAGCCUGGCCUUCAUCAGAAAGUCCGAUGAGCUGCUGCACAACGUGAACGCCGGCAAGUCCACCACCAAUAUCAUGAUCACGACCAUCAUCAUCGUGAUUAUCGUGAUCCUGCUGUCCCUGAUCGCCGUGGGCCUGCUGCUUUAUUGAUAAUAGGCUGGAGCCUCGGUGGCCAUGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCUUCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
142. YK-RSV-046 DNA, SEQ ID NO: 142
AGCGGCTCGGCCATTTTGTCCCAGTCAGTCCGGAGGCTGCGGCTGCAGAAGTACCGCCTGCGGAGTAACTGCAAAGGCCACCATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCAGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCTCTTTCTGCGGCTTTCTGCTCGGAGTGGGCAGCGCCATTGCCTCTGGTGTCGCCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCCTGAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGAGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGATGCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTACGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCGACGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAGGCTGGAGCCTCGGTGGCCATGCTTCTTGCCCCTTGGGCCTCCCCCCAGCCCCTCCTCCCCTTCCTGCACCCGTACCCCCGTGGTCTTTGAATAAAGTCTGAGTGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
143. YK-RSV-046 ORF NT, SEQ ID NO: 143
ATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCAGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCTCTTTCTGCGGCTTTCTGCTCGGAGTGGGCAGCGCCATTGCCTCTGGTGTCGCCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCCTGAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGAGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGATGCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTACGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCGACGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAG
144. YK-RSV-046 ORF AA, SEQ ID NO: 144
MELLILKANAITTILTAVTFCFASGQNITEEFYQSTCSAVSKGYLGALRTGWYTSVITIELSNIKENKCNGTDAKVKLIKQELDKYKNAVTDLQLLMQSTPATGSGSFCGFLLGVGSAIASGVAVSKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTFKVLDLKNYIDKQLLPILNKQSCSIPNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMSIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRCDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSRTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEGQSLYVKGEPIINFYDPLVFPSDEFDASISQVNEKINQSLAFIRKSDELLHNVNAGKSTTNIMITTIIIVIIVILLSLIAVGLLLY
145. YK-RSV-046 mRNA, SEQ ID NO: 145
AGCGGCUCGGCCAUUUUGUCCCAGUCAGUCCGGAGGCUGCGGCUGCAGAAGUACCGCCUGCGGAGUAACUGCAAAGGCCACCAUGGAACUGCUGAUCCUGAAGGCCAACGCCAUCACCACCAUCCUGACCGCCGUGACCUUCUGUUUUGCCAGCGGCCAGAACAUCACCGAGGAAUUCUACCAGAGCACCUGUAGCGCCGUGUCCAAGGGAUAUCUGGGCGCCCUUAGAACCGGCUGGUACACCAGCGUGAUCACCAUCGAGCUGAGCAACAUCAAAGAAAACAAGUGCAACGGCACCGACGCCAAAGUGAAGCUGAUCAAGCAAGAGCUGGACAAGUACAAGAAUGCCGUGACCGACCUGCAGCUGCUGAUGCAGUCUACACCAGCCACAGGCUCUGGCUCUUUCUGCGGCUUUCUGCUCGGAGUGGGCAGCGCCAUUGCCUCUGGUGUCGCCGUGUCUAAAGUGCUGCACCUGGAAGGCGAAGUGAACAAGAUCAAGAGCGCCCUGCUGAGCACCAACAAGGCCGUGGUGUCUCUGAGCAAUGGCGUGUCCGUGCUGACCUUCAAGGUGCUGGACCUGAAGAACUACAUCGACAAACAGCUGCUGCCCAUCCUGAACAAGCAGUCCUGCAGCAUCCCCAACAUCGAGACAGUGAUCGAGUUCCAGCAGAAGAACAACCGGCUGCUGGAAAUCACCCGCGAGUUCUCUGUGAAUGCCGGCGUGACCACACCUGUGUCCACCUACAUGCUGACCAACAGCGAGCUGCUGAGCCUGAUCAACGACAUGCCCAUCACCAACGACCAGAAAAAGCUGAUGAGCAACAACGUGCAGAUCGUGCGGCAGCAGAGCUACAGCAUCAUGAGCAUUAUCAAAGAAGAGGUGCUGGCCUACGUGGUGCAGCUGCCUCUGUAUGGCGUGAUCGAUACCCCUUGCUGGAAGCUGCACACAAGCCCUCUGUGCACCACCAACACCAAAGAGGGCAGCAACAUCUGCCUGACCAGAUGCGACAGAGGCUGGUACUGCGAUAAUGCCGGCAGCGUCUCAUUCUUCCCACAAGCCGAGACAUGCAAGGUGCAGAGCAACCGGGUGUUCUGCGACACCAUGAAUAGCAGAACCCUGCCUUCCGAAGUGAAUCUGUGCAACGUGGACAUCUUCAACCCUAAGUACGACUGCAAGAUCAUGACCAGCAAGACCGACGUGUCCAGCAGUGUGAUCACCUCACUGGGCGCCAUCGUGUCCUGUUACGGCAAGACCAAGUGCACCGCCAGCAACAAGAACCGGGGCAUCAUCAAGACCUUCAGCAACGGCUGCGACUACGUGUCCAACAAAGGCGUGGACACCGUGUCUGUGGGCAACACCCUGUACUACGUGAACAAACAAGAGGGCCAGUCUCUGUACGUGAAGGGCGAGCCCAUCAUCAACUUCUACGACCCUCUGGUGUUCCCCAGCGACGAGUUCGAUGCCAGCAUCAGCCAAGUGAACGAGAAGAUCAAUCAGAGCCUGGCCUUCAUCAGAAAGUCCGAUGAGCUGCUGCACAACGUGAACGCCGGCAAGUCCACCACCAAUAUCAUGAUCACGACCAUCAUCAUCGUGAUUAUCGUGAUCCUGCUGUCCCUGAUCGCCGUGGGCCUGCUGCUUUAUUGAUAAUAGGCUGGAGCCUCGGUGGCCAUGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCUUCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
146. YK-RSV-047 DNA, SEQ ID NO: 146
AGCGGCTCGGCCATTTTGTCCCAGTCAGTCCGGAGGCTGCGGCTGCAGAAGTACCGCCTGCGGAGTAACTGCAAAGGCCACCATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCAGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCTCTTTCCTGTGCTTTCTGCTCGGAGTGGGCAGCGCCATTGCCTCTGGTGTCGCCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCCTGAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGAGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCATGCGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTACGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCGACGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAGGCTGGAGCCTCGGTGGCCATGCTTCTTGCCCCTTGGGCCTCCCCCCAGCCCCTCCTCCCCTTCCTGCACCCGTACCCCCGTGGTCTTTGAATAAAGTCTGAGTGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
147. YK-RSV-047 ORF NT, SEQ ID NO: 147
ATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCAGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCTCTTTCCTGTGCTTTCTGCTCGGAGTGGGCAGCGCCATTGCCTCTGGTGTCGCCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCCTGAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGAGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCATGCGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTACGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCGACGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAG
148. YK-RSV-047 ORF AA, SEQ ID NO: 148
MELLILKANAITTILTAVTFCFASGQNITEEFYQSTCSAVSKGYLGALRTGWYTSVITIELSNIKENKCNGTDAKVKLIKQELDKYKNAVTDLQLLMQSTPATGSGSFLCFLLGVGSAIASGVAVSKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTFKVLDLKNYIDKQLLPILNKQSCSIPNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMSIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPCAETCKVQSNRVFCDTMNSRTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEGQSLYVKGEPIINFYDPLVFPSDEFDASISQVNEKINQSLAFIRKSDELLHNVNAGKSTTNIMITTIIIVIIVILLSLIAVGLLLY
149. YK-RSV-047 mRNA, SEQ ID NO: 149
AGCGGCUCGGCCAUUUUGUCCCAGUCAGUCCGGAGGCUGCGGCUGCAGAAGUACCGCCUGCGGAGUAACUGCAAAGGCCACCAUGGAACUGCUGAUCCUGAAGGCCAACGCCAUCACCACCAUCCUGACCGCCGUGACCUUCUGUUUUGCCAGCGGCCAGAACAUCACCGAGGAAUUCUACCAGAGCACCUGUAGCGCCGUGUCCAAGGGAUAUCUGGGCGCCCUUAGAACCGGCUGGUACACCAGCGUGAUCACCAUCGAGCUGAGCAACAUCAAAGAAAACAAGUGCAACGGCACCGACGCCAAAGUGAAGCUGAUCAAGCAAGAGCUGGACAAGUACAAGAAUGCCGUGACCGACCUGCAGCUGCUGAUGCAGUCUACACCAGCCACAGGCUCUGGCUCUUUCCUGUGCUUUCUGCUCGGAGUGGGCAGCGCCAUUGCCUCUGGUGUCGCCGUGUCUAAAGUGCUGCACCUGGAAGGCGAAGUGAACAAGAUCAAGAGCGCCCUGCUGAGCACCAACAAGGCCGUGGUGUCUCUGAGCAAUGGCGUGUCCGUGCUGACCUUCAAGGUGCUGGACCUGAAGAACUACAUCGACAAACAGCUGCUGCCCAUCCUGAACAAGCAGUCCUGCAGCAUCCCCAACAUCGAGACAGUGAUCGAGUUCCAGCAGAAGAACAACCGGCUGCUGGAAAUCACCCGCGAGUUCUCUGUGAAUGCCGGCGUGACCACACCUGUGUCCACCUACAUGCUGACCAACAGCGAGCUGCUGAGCCUGAUCAACGACAUGCCCAUCACCAACGACCAGAAAAAGCUGAUGAGCAACAACGUGCAGAUCGUGCGGCAGCAGAGCUACAGCAUCAUGAGCAUUAUCAAAGAAGAGGUGCUGGCCUACGUGGUGCAGCUGCCUCUGUAUGGCGUGAUCGAUACCCCUUGCUGGAAGCUGCACACAAGCCCUCUGUGCACCACCAACACCAAAGAGGGCAGCAACAUCUGCCUGACCAGAACCGACAGAGGCUGGUACUGCGAUAAUGCCGGCAGCGUCUCAUUCUUCCCAUGCGCCGAGACAUGCAAGGUGCAGAGCAACCGGGUGUUCUGCGACACCAUGAAUAGCAGAACCCUGCCUUCCGAAGUGAAUCUGUGCAACGUGGACAUCUUCAACCCUAAGUACGACUGCAAGAUCAUGACCAGCAAGACCGACGUGUCCAGCAGUGUGAUCACCUCACUGGGCGCCAUCGUGUCCUGUUACGGCAAGACCAAGUGCACCGCCAGCAACAAGAACCGGGGCAUCAUCAAGACCUUCAGCAACGGCUGCGACUACGUGUCCAACAAAGGCGUGGACACCGUGUCUGUGGGCAACACCCUGUACUACGUGAACAAACAAGAGGGCCAGUCUCUGUACGUGAAGGGCGAGCCCAUCAUCAACUUCUACGACCCUCUGGUGUUCCCCAGCGACGAGUUCGAUGCCAGCAUCAGCCAAGUGAACGAGAAGAUCAAUCAGAGCCUGGCCUUCAUCAGAAAGUCCGAUGAGCUGCUGCACAACGUGAACGCCGGCAAGUCCACCACCAAUAUCAUGAUCACGACCAUCAUCAUCGUGAUUAUCGUGAUCCUGCUGUCCCUGAUCGCCGUGGGCCUGCUGCUUUAUUGAUAAUAGGCUGGAGCCUCGGUGGCCAUGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCUUCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
150. YK-RSV-048 DNA, SEQ ID NO: 150
AGCGGCTCGGCCATTTTGTCCCAGTCAGTCCGGAGGCTGCGGCTGCAGAAGTACCGCCTGCGGAGTAACTGCAAAGGCCACCATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCAGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCTCTTTCCTGGGCTTTCTGTGCGGAGTGGGCAGCGCCATTGCCTCTGGTGTCGCCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCCTGAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGAGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGTGCAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTACGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCGACGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAGGCTGGAGCCTCGGTGGCCATGCTTCTTGCCCCTTGGGCCTCCCCCCAGCCCCTCCTCCCCTTCCTGCACCCGTACCCCCGTGGTCTTTGAATAAAGTCTGAGTGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
151. YK-RSV-048 ORF NT, SEQ ID NO: 151
ATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCAGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCTCTTTCCTGGGCTTTCTGTGCGGAGTGGGCAGCGCCATTGCCTCTGGTGTCGCCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCCTGAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGAGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGTGCAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTACGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCGACGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAG
152. YK-RSV-048 ORF AA, SEQ ID NO: 152
MELLILKANAITTILTAVTFCFASGQNITEEFYQSTCSAVSKGYLGALRTGWYTSVITIELSNIKENKCNGTDAKVKLIKQELDKYKNAVTDLQLLMQSTPATGSGSFLGFLCGVGSAIASGVAVSKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTFKVLDLKNYIDKQLLPILNKQSCSIPNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMSIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMCSRTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEGQSLYVKGEPIINFYDPLVFPSDEFDASISQVNEKINQSLAFIRKSDELLHNVNAGKSTTNIMITTIIIVIIVILLSLIAVGLLLY
153. YK-RSV-048 mRNA, SEQ ID NO: 153
AGCGGCUCGGCCAUUUUGUCCCAGUCAGUCCGGAGGCUGCGGCUGCAGAAGUACCGCCUGCGGAGUAACUGCAAAGGCCACCAUGGAACUGCUGAUCCUGAAGGCCAACGCCAUCACCACCAUCCUGACCGCCGUGACCUUCUGUUUUGCCAGCGGCCAGAACAUCACCGAGGAAUUCUACCAGAGCACCUGUAGCGCCGUGUCCAAGGGAUAUCUGGGCGCCCUUAGAACCGGCUGGUACACCAGCGUGAUCACCAUCGAGCUGAGCAACAUCAAAGAAAACAAGUGCAACGGCACCGACGCCAAAGUGAAGCUGAUCAAGCAAGAGCUGGACAAGUACAAGAAUGCCGUGACCGACCUGCAGCUGCUGAUGCAGUCUACACCAGCCACAGGCUCUGGCUCUUUCCUGGGCUUUCUGUGCGGAGUGGGCAGCGCCAUUGCCUCUGGUGUCGCCGUGUCUAAAGUGCUGCACCUGGAAGGCGAAGUGAACAAGAUCAAGAGCGCCCUGCUGAGCACCAACAAGGCCGUGGUGUCUCUGAGCAAUGGCGUGUCCGUGCUGACCUUCAAGGUGCUGGACCUGAAGAACUACAUCGACAAACAGCUGCUGCCCAUCCUGAACAAGCAGUCCUGCAGCAUCCCCAACAUCGAGACAGUGAUCGAGUUCCAGCAGAAGAACAACCGGCUGCUGGAAAUCACCCGCGAGUUCUCUGUGAAUGCCGGCGUGACCACACCUGUGUCCACCUACAUGCUGACCAACAGCGAGCUGCUGAGCCUGAUCAACGACAUGCCCAUCACCAACGACCAGAAAAAGCUGAUGAGCAACAACGUGCAGAUCGUGCGGCAGCAGAGCUACAGCAUCAUGAGCAUUAUCAAAGAAGAGGUGCUGGCCUACGUGGUGCAGCUGCCUCUGUAUGGCGUGAUCGAUACCCCUUGCUGGAAGCUGCACACAAGCCCUCUGUGCACCACCAACACCAAAGAGGGCAGCAACAUCUGCCUGACCAGAACCGACAGAGGCUGGUACUGCGAUAAUGCCGGCAGCGUCUCAUUCUUCCCACAAGCCGAGACAUGCAAGGUGCAGAGCAACCGGGUGUUCUGCGACACCAUGUGCAGCAGAACCCUGCCUUCCGAAGUGAAUCUGUGCAACGUGGACAUCUUCAACCCUAAGUACGACUGCAAGAUCAUGACCAGCAAGACCGACGUGUCCAGCAGUGUGAUCACCUCACUGGGCGCCAUCGUGUCCUGUUACGGCAAGACCAAGUGCACCGCCAGCAACAAGAACCGGGGCAUCAUCAAGACCUUCAGCAACGGCUGCGACUACGUGUCCAACAAAGGCGUGGACACCGUGUCUGUGGGCAACACCCUGUACUACGUGAACAAACAAGAGGGCCAGUCUCUGUACGUGAAGGGCGAGCCCAUCAUCAACUUCUACGACCCUCUGGUGUUCCCCAGCGACGAGUUCGAUGCCAGCAUCAGCCAAGUGAACGAGAAGAUCAAUCAGAGCCUGGCCUUCAUCAGAAAGUCCGAUGAGCUGCUGCACAACGUGAACGCCGGCAAGUCCACCACCAAUAUCAUGAUCACGACCAUCAUCAUCGUGAUUAUCGUGAUCCUGCUGUCCCUGAUCGCCGUGGGCCUGCUGCUUUAUUGAUAAUAGGCUGGAGCCUCGGUGGCCAUGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCUUCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
154. YK-RSV-049 DNA, SEQ ID NO: 154
AGCGGCTCGGCCATTTTGTCCCAGTCAGTCCGGAGGCTGCGGCTGCAGAAGTACCGCCTGCGGAGTAACTGCAAAGGCCACCATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCAGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCTCTTTCCTGGGCTTTCTGCTCGGAGTGTGCAGCGCCATTGCCTCTGGTGTCGCCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCCTGAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGAGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCTGCAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTACGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCGACGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAGGCTGGAGCCTCGGTGGCCATGCTTCTTGCCCCTTGGGCCTCCCCCCAGCCCCTCCTCCCCTTCCTGCACCCGTACCCCCGTGGTCTTTGAATAAAGTCTGAGTGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
155. YK-RSV-049 ORF NT, SEQ ID NO: 155
ATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCAGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCTCTTTCCTGGGCTTTCTGCTCGGAGTGTGCAGCGCCATTGCCTCTGGTGTCGCCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCCTGAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGAGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCTGCAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTACGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCGACGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAG
156. YK-RSV-049 ORF AA, SEQ ID NO: 156
MELLILKANAITTILTAVTFCFASGQNITEEFYQSTCSAVSKGYLGALRTGWYTSVITIELSNIKENKCNGTDAKVKLIKQELDKYKNAVTDLQLLMQSTPATGSGSFLGFLLGVCSAIASGVAVSKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTFKVLDLKNYIDKQLLPILNKQSCSIPNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMSIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTCNSRTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEGQSLYVKGEPIINFYDPLVFPSDEFDASISQVNEKINQSLAFIRKSDELLHNVNAGKSTTNIMITTIIIVIIVILLSLIAVGLLLY
157. YK-RSV-049 mRNA, SEQ ID NO: 157
AGCGGCUCGGCCAUUUUGUCCCAGUCAGUCCGGAGGCUGCGGCUGCAGAAGUACCGCCUGCGGAGUAACUGCAAAGGCCACCAUGGAACUGCUGAUCCUGAAGGCCAACGCCAUCACCACCAUCCUGACCGCCGUGACCUUCUGUUUUGCCAGCGGCCAGAACAUCACCGAGGAAUUCUACCAGAGCACCUGUAGCGCCGUGUCCAAGGGAUAUCUGGGCGCCCUUAGAACCGGCUGGUACACCAGCGUGAUCACCAUCGAGCUGAGCAACAUCAAAGAAAACAAGUGCAACGGCACCGACGCCAAAGUGAAGCUGAUCAAGCAAGAGCUGGACAAGUACAAGAAUGCCGUGACCGACCUGCAGCUGCUGAUGCAGUCUACACCAGCCACAGGCUCUGGCUCUUUCCUGGGCUUUCUGCUCGGAGUGUGCAGCGCCAUUGCCUCUGGUGUCGCCGUGUCUAAAGUGCUGCACCUGGAAGGCGAAGUGAACAAGAUCAAGAGCGCCCUGCUGAGCACCAACAAGGCCGUGGUGUCUCUGAGCAAUGGCGUGUCCGUGCUGACCUUCAAGGUGCUGGACCUGAAGAACUACAUCGACAAACAGCUGCUGCCCAUCCUGAACAAGCAGUCCUGCAGCAUCCCCAACAUCGAGACAGUGAUCGAGUUCCAGCAGAAGAACAACCGGCUGCUGGAAAUCACCCGCGAGUUCUCUGUGAAUGCCGGCGUGACCACACCUGUGUCCACCUACAUGCUGACCAACAGCGAGCUGCUGAGCCUGAUCAACGACAUGCCCAUCACCAACGACCAGAAAAAGCUGAUGAGCAACAACGUGCAGAUCGUGCGGCAGCAGAGCUACAGCAUCAUGAGCAUUAUCAAAGAAGAGGUGCUGGCCUACGUGGUGCAGCUGCCUCUGUAUGGCGUGAUCGAUACCCCUUGCUGGAAGCUGCACACAAGCCCUCUGUGCACCACCAACACCAAAGAGGGCAGCAACAUCUGCCUGACCAGAACCGACAGAGGCUGGUACUGCGAUAAUGCCGGCAGCGUCUCAUUCUUCCCACAAGCCGAGACAUGCAAGGUGCAGAGCAACCGGGUGUUCUGCGACACCUGCAAUAGCAGAACCCUGCCUUCCGAAGUGAAUCUGUGCAACGUGGACAUCUUCAACCCUAAGUACGACUGCAAGAUCAUGACCAGCAAGACCGACGUGUCCAGCAGUGUGAUCACCUCACUGGGCGCCAUCGUGUCCUGUUACGGCAAGACCAAGUGCACCGCCAGCAACAAGAACCGGGGCAUCAUCAAGACCUUCAGCAACGGCUGCGACUACGUGUCCAACAAAGGCGUGGACACCGUGUCUGUGGGCAACACCCUGUACUACGUGAACAAACAAGAGGGCCAGUCUCUGUACGUGAAGGGCGAGCCCAUCAUCAACUUCUACGACCCUCUGGUGUUCCCCAGCGACGAGUUCGAUGCCAGCAUCAGCCAAGUGAACGAGAAGAUCAAUCAGAGCCUGGCCUUCAUCAGAAAGUCCGAUGAGCUGCUGCACAACGUGAACGCCGGCAAGUCCACCACCAAUAUCAUGAUCACGACCAUCAUCAUCGUGAUUAUCGUGAUCCUGCUGUCCCUGAUCGCCGUGGGCCUGCUGCUUUAUUGAUAAUAGGCUGGAGCCUCGGUGGCCAUGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCUUCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
158. YK-RSV-050 DNA, SEQ ID NO: 158
AGCGGCTCGGCCATTTTGTCCCAGTCAGTCCGGAGGCTGCGGCTGCAGAAGTACCGCCTGCGGAGTAACTGCAAAGGCCACCATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCAGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCTCTTTCCTGGGCTTTTGCCTCGGAGTGGGCAGCGCCATTGCCTCTGGTGTCGCCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCCTGAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGAGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGTGCAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTACGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCGACGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAGGCTGGAGCCTCGGTGGCCATGCTTCTTGCCCCTTGGGCCTCCCCCCAGCCCCTCCTCCCCTTCCTGCACCCGTACCCCCGTGGTCTTTGAATAAAGTCTGAGTGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
159. YK-RSV-050 ORF NT, SEQ ID NO: 159
ATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCAGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCTCTTTCCTGGGCTTTTGCCTCGGAGTGGGCAGCGCCATTGCCTCTGGTGTCGCCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCCTGAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGAGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGTGCAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTACGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCGACGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAG
160. YK-RSV-050 ORF AA, SEQ ID NO: 160
MELLILKANAITTILTAVTFCFASGQNITEEFYQSTCSAVSKGYLGALRTGWYTSVITIELSNIKENKCNGTDAKVKLIKQELDKYKNAVTDLQLLMQSTPATGSGSFLGFCLGVGSAIASGVAVSKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTFKVLDLKNYIDKQLLPILNKQSCSIPNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMSIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMCSRTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEGQSLYVKGEPIINFYDPLVFPSDEFDASISQVNEKINQSLAFIRKSDELLHNVNAGKSTTNIMITTIIIVIIVILLSLIAVGLLLY
161. YK-RSV-050 mRNA, SEQ ID NO: 161
AGCGGCUCGGCCAUUUUGUCCCAGUCAGUCCGGAGGCUGCGGCUGCAGAAGUACCGCCUGCGGAGUAACUGCAAAGGCCACCAUGGAACUGCUGAUCCUGAAGGCCAACGCCAUCACCACCAUCCUGACCGCCGUGACCUUCUGUUUUGCCAGCGGCCAGAACAUCACCGAGGAAUUCUACCAGAGCACCUGUAGCGCCGUGUCCAAGGGAUAUCUGGGCGCCCUUAGAACCGGCUGGUACACCAGCGUGAUCACCAUCGAGCUGAGCAACAUCAAAGAAAACAAGUGCAACGGCACCGACGCCAAAGUGAAGCUGAUCAAGCAAGAGCUGGACAAGUACAAGAAUGCCGUGACCGACCUGCAGCUGCUGAUGCAGUCUACACCAGCCACAGGCUCUGGCUCUUUCCUGGGCUUUUGCCUCGGAGUGGGCAGCGCCAUUGCCUCUGGUGUCGCCGUGUCUAAAGUGCUGCACCUGGAAGGCGAAGUGAACAAGAUCAAGAGCGCCCUGCUGAGCACCAACAAGGCCGUGGUGUCUCUGAGCAAUGGCGUGUCCGUGCUGACCUUCAAGGUGCUGGACCUGAAGAACUACAUCGACAAACAGCUGCUGCCCAUCCUGAACAAGCAGUCCUGCAGCAUCCCCAACAUCGAGACAGUGAUCGAGUUCCAGCAGAAGAACAACCGGCUGCUGGAAAUCACCCGCGAGUUCUCUGUGAAUGCCGGCGUGACCACACCUGUGUCCACCUACAUGCUGACCAACAGCGAGCUGCUGAGCCUGAUCAACGACAUGCCCAUCACCAACGACCAGAAAAAGCUGAUGAGCAACAACGUGCAGAUCGUGCGGCAGCAGAGCUACAGCAUCAUGAGCAUUAUCAAAGAAGAGGUGCUGGCCUACGUGGUGCAGCUGCCUCUGUAUGGCGUGAUCGAUACCCCUUGCUGGAAGCUGCACACAAGCCCUCUGUGCACCACCAACACCAAAGAGGGCAGCAACAUCUGCCUGACCAGAACCGACAGAGGCUGGUACUGCGAUAAUGCCGGCAGCGUCUCAUUCUUCCCACAAGCCGAGACAUGCAAGGUGCAGAGCAACCGGGUGUUCUGCGACACCAUGUGCAGCAGAACCCUGCCUUCCGAAGUGAAUCUGUGCAACGUGGACAUCUUCAACCCUAAGUACGACUGCAAGAUCAUGACCAGCAAGACCGACGUGUCCAGCAGUGUGAUCACCUCACUGGGCGCCAUCGUGUCCUGUUACGGCAAGACCAAGUGCACCGCCAGCAACAAGAACCGGGGCAUCAUCAAGACCUUCAGCAACGGCUGCGACUACGUGUCCAACAAAGGCGUGGACACCGUGUCUGUGGGCAACACCCUGUACUACGUGAACAAACAAGAGGGCCAGUCUCUGUACGUGAAGGGCGAGCCCAUCAUCAACUUCUACGACCCUCUGGUGUUCCCCAGCGACGAGUUCGAUGCCAGCAUCAGCCAAGUGAACGAGAAGAUCAAUCAGAGCCUGGCCUUCAUCAGAAAGUCCGAUGAGCUGCUGCACAACGUGAACGCCGGCAAGUCCACCACCAAUAUCAUGAUCACGACCAUCAUCAUCGUGAUUAUCGUGAUCCUGCUGUCCCUGAUCGCCGUGGGCCUGCUGCUUUAUUGAUAAUAGGCUGGAGCCUCGGUGGCCAUGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCUUCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
162. YK-RSV-051 DNA, SEQ ID NO: 162
AGCGGCTCGGCCATTTTGTCCCAGTCAGTCCGGAGGCTGCGGCTGCAGAAGTACCGCCTGCGGAGTAACTGCAAAGGCCACCATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCAGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCTCTTTCCTGGGCTGCCTGCTCGGAGTGGGCAGCGCCATTGCCTCTGGTGTCGCCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCCTGAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGAGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACTGCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTACGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCGACGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAGGCTGGAGCCTCGGTGGCCATGCTTCTTGCCCCTTGGGCCTCCCCCCAGCCCCTCCTCCCCTTCCTGCACCCGTACCCCCGTGGTCTTTGAATAAAGTCTGAGTGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
163. YK-RSV-051 ORF NT, SEQ ID NO: 163
ATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCAGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCTCTTTCCTGGGCTGCCTGCTCGGAGTGGGCAGCGCCATTGCCTCTGGTGTCGCCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCCTGAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGAGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACTGCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTACGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCGACGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAG
164. YK-RSV-051 ORF AA, SEQ ID NO: 164
MELLILKANAITTILTAVTFCFASGQNITEEFYQSTCSAVSKGYLGALRTGWYTSVITIELSNIKENKCNGTDAKVKLIKQELDKYKNAVTDLQLLMQSTPATGSGSFLGCLLGVGSAIASGVAVSKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTFKVLDLKNYIDKQLLPILNKQSCSIPNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMSIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDCMNSRTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEGQSLYVKGEPIINFYDPLVFPSDEFDASISQVNEKINQSLAFIRKSDELLHNVNAGKSTTNIMITTIIIVIIVILLSLIAVGLLLY
165. YK-RSV-051 mRNA, SEQ ID NO: 165
AGCGGCUCGGCCAUUUUGUCCCAGUCAGUCCGGAGGCUGCGGCUGCAGAAGUACCGCCUGCGGAGUAACUGCAAAGGCCACCAUGGAACUGCUGAUCCUGAAGGCCAACGCCAUCACCACCAUCCUGACCGCCGUGACCUUCUGUUUUGCCAGCGGCCAGAACAUCACCGAGGAAUUCUACCAGAGCACCUGUAGCGCCGUGUCCAAGGGAUAUCUGGGCGCCCUUAGAACCGGCUGGUACACCAGCGUGAUCACCAUCGAGCUGAGCAACAUCAAAGAAAACAAGUGCAACGGCACCGACGCCAAAGUGAAGCUGAUCAAGCAAGAGCUGGACAAGUACAAGAAUGCCGUGACCGACCUGCAGCUGCUGAUGCAGUCUACACCAGCCACAGGCUCUGGCUCUUUCCUGGGCUGCCUGCUCGGAGUGGGCAGCGCCAUUGCCUCUGGUGUCGCCGUGUCUAAAGUGCUGCACCUGGAAGGCGAAGUGAACAAGAUCAAGAGCGCCCUGCUGAGCACCAACAAGGCCGUGGUGUCUCUGAGCAAUGGCGUGUCCGUGCUGACCUUCAAGGUGCUGGACCUGAAGAACUACAUCGACAAACAGCUGCUGCCCAUCCUGAACAAGCAGUCCUGCAGCAUCCCCAACAUCGAGACAGUGAUCGAGUUCCAGCAGAAGAACAACCGGCUGCUGGAAAUCACCCGCGAGUUCUCUGUGAAUGCCGGCGUGACCACACCUGUGUCCACCUACAUGCUGACCAACAGCGAGCUGCUGAGCCUGAUCAACGACAUGCCCAUCACCAACGACCAGAAAAAGCUGAUGAGCAACAACGUGCAGAUCGUGCGGCAGCAGAGCUACAGCAUCAUGAGCAUUAUCAAAGAAGAGGUGCUGGCCUACGUGGUGCAGCUGCCUCUGUAUGGCGUGAUCGAUACCCCUUGCUGGAAGCUGCACACAAGCCCUCUGUGCACCACCAACACCAAAGAGGGCAGCAACAUCUGCCUGACCAGAACCGACAGAGGCUGGUACUGCGAUAAUGCCGGCAGCGUCUCAUUCUUCCCACAAGCCGAGACAUGCAAGGUGCAGAGCAACCGGGUGUUCUGCGACUGCAUGAAUAGCAGAACCCUGCCUUCCGAAGUGAAUCUGUGCAACGUGGACAUCUUCAACCCUAAGUACGACUGCAAGAUCAUGACCAGCAAGACCGACGUGUCCAGCAGUGUGAUCACCUCACUGGGCGCCAUCGUGUCCUGUUACGGCAAGACCAAGUGCACCGCCAGCAACAAGAACCGGGGCAUCAUCAAGACCUUCAGCAACGGCUGCGACUACGUGUCCAACAAAGGCGUGGACACCGUGUCUGUGGGCAACACCCUGUACUACGUGAACAAACAAGAGGGCCAGUCUCUGUACGUGAAGGGCGAGCCCAUCAUCAACUUCUACGACCCUCUGGUGUUCCCCAGCGACGAGUUCGAUGCCAGCAUCAGCCAAGUGAACGAGAAGAUCAAUCAGAGCCUGGCCUUCAUCAGAAAGUCCGAUGAGCUGCUGCACAACGUGAACGCCGGCAAGUCCACCACCAAUAUCAUGAUCACGACCAUCAUCAUCGUGAUUAUCGUGAUCCUGCUGUCCCUGAUCGCCGUGGGCCUGCUGCUUUAUUGAUAAUAGGCUGGAGCCUCGGUGGCCAUGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCUUCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
166. YK-RSV-052 DNA, SEQ ID NO: 166
AGCGGCTCGGCCATTTTGTCCCAGTCAGTCCGGAGGCTGCGGCTGCAGAAGTACCGCCTGCGGAGTAACTGCAAAGGCCACCATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCAGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCTGCGCCATTGCCTCTGGTGTCGCCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCCTGAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGAGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTTGCTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTACGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCGACGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAGGCTGGAGCCTCGGTGGCCATGCTTCTTGCCCCTTGGGCCTCCCCCCAGCCCCTCCTCCCCTTCCTGCACCCGTACCCCCGTGGTCTTTGAATAAAGTCTGAGTGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
167. YK-RSV-052 ORF NT, SEQ ID NO: 167
ATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCAGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCTGCGCCATTGCCTCTGGTGTCGCCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCCTGAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGAGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTTGCTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTACGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCGACGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAG
168 YK-RSV-052 ORF AA, SEQ ID NO: 168
MELLILKANAITTILTAVTFCFASGQNITEEFYQSTCSAVSKGYLGALRTGWYTSVITIELSNIKENKCNGTDAKVKLIKQELDKYKNAVTDLQLLMQSTPATGSGCAIASGVAVSKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTFKVLDLKNYIDKQLLPILNKQSCSIPNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMSIIKEEVLAYVVQLPCYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSRTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEGQSLYVKGEPIINFYDPLVFPSDEFDASISQVNEKINQSLAFIRKSDELLHNVNAGKSTTNIMITTIIIVIIVILLSLIAVGLLLY
169. YK-RSV-052 mRNA, SEQ ID NO: 169
AGCGGCUCGGCCAUUUUGUCCCAGUCAGUCCGGAGGCUGCGGCUGCAGAAGUACCGCCUGCGGAGUAACUGCAAAGGCCACCAUGGAACUGCUGAUCCUGAAGGCCAACGCCAUCACCACCAUCCUGACCGCCGUGACCUUCUGUUUUGCCAGCGGCCAGAACAUCACCGAGGAAUUCUACCAGAGCACCUGUAGCGCCGUGUCCAAGGGAUAUCUGGGCGCCCUUAGAACCGGCUGGUACACCAGCGUGAUCACCAUCGAGCUGAGCAACAUCAAAGAAAACAAGUGCAACGGCACCGACGCCAAAGUGAAGCUGAUCAAGCAAGAGCUGGACAAGUACAAGAAUGCCGUGACCGACCUGCAGCUGCUGAUGCAGUCUACACCAGCCACAGGCUCUGGCUGCGCCAUUGCCUCUGGUGUCGCCGUGUCUAAAGUGCUGCACCUGGAAGGCGAAGUGAACAAGAUCAAGAGCGCCCUGCUGAGCACCAACAAGGCCGUGGUGUCUCUGAGCAAUGGCGUGUCCGUGCUGACCUUCAAGGUGCUGGACCUGAAGAACUACAUCGACAAACAGCUGCUGCCCAUCCUGAACAAGCAGUCCUGCAGCAUCCCCAACAUCGAGACAGUGAUCGAGUUCCAGCAGAAGAACAACCGGCUGCUGGAAAUCACCCGCGAGUUCUCUGUGAAUGCCGGCGUGACCACACCUGUGUCCACCUACAUGCUGACCAACAGCGAGCUGCUGAGCCUGAUCAACGACAUGCCCAUCACCAACGACCAGAAAAAGCUGAUGAGCAACAACGUGCAGAUCGUGCGGCAGCAGAGCUACAGCAUCAUGAGCAUUAUCAAAGAAGAGGUGCUGGCCUACGUGGUGCAGCUGCCUUGCUAUGGCGUGAUCGAUACCCCUUGCUGGAAGCUGCACACAAGCCCUCUGUGCACCACCAACACCAAAGAGGGCAGCAACAUCUGCCUGACCAGAACCGACAGAGGCUGGUACUGCGAUAAUGCCGGCAGCGUCUCAUUCUUCCCACAAGCCGAGACAUGCAAGGUGCAGAGCAACCGGGUGUUCUGCGACACCAUGAAUAGCAGAACCCUGCCUUCCGAAGUGAAUCUGUGCAACGUGGACAUCUUCAACCCUAAGUACGACUGCAAGAUCAUGACCAGCAAGACCGACGUGUCCAGCAGUGUGAUCACCUCACUGGGCGCCAUCGUGUCCUGUUACGGCAAGACCAAGUGCACCGCCAGCAACAAGAACCGGGGCAUCAUCAAGACCUUCAGCAACGGCUGCGACUACGUGUCCAACAAAGGCGUGGACACCGUGUCUGUGGGCAACACCCUGUACUACGUGAACAAACAAGAGGGCCAGUCUCUGUACGUGAAGGGCGAGCCCAUCAUCAACUUCUACGACCCUCUGGUGUUCCCCAGCGACGAGUUCGAUGCCAGCAUCAGCCAAGUGAACGAGAAGAUCAAUCAGAGCCUGGCCUUCAUCAGAAAGUCCGAUGAGCUGCUGCACAACGUGAACGCCGGCAAGUCCACCACCAAUAUCAUGAUCACGACCAUCAUCAUCGUGAUUAUCGUGAUCCUGCUGUCCCUGAUCGCCGUGGGCCUGCUGCUUUAUUGAUAAUAGGCUGGAGCCUCGGUGGCCAUGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCUUCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
170. YK-RSV-053 DNA, SEQ ID NO: 170
AGCGGCTCGGCCATTTTGTCCCAGTCAGTCCGGAGGCTGCGGCTGCAGAAGTACCGCCTGCGGAGTAACTGCAAAGGCCACCATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCAGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCAGCGCCATTTGCTCTGGTGTCGCCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCCTGAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGAGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTGCGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTACGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCGACGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAGGCTGGAGCCTCGGTGGCCATGCTTCTTGCCCCTTGGGCCTCCCCCCAGCCCCTCCTCCCCTTCCTGCACCCGTACCCCCGTGGTCTTTGAATAAAGTCTGAGTGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
171. YK-RSV-053 ORF NT, SEQ ID NO: 171
ATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCAGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCAGCGCCATTTGCTCTGGTGTCGCCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCCTGAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGAGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTGCGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTACGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCGACGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAG
172. YK-RSV-053 ORF AA, SEQ ID NO: 172
MELLILKANAITTILTAVTFCFASGQNITEEFYQSTCSAVSKGYLGALRTGWYTSVITIELSNIKENKCNGTDAKVKLIKQELDKYKNAVTDLQLLMQSTPATGSGSAICSGVAVSKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTFKVLDLKNYIDKQLLPILNKQSCSIPNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMSIIKEEVLAYVVQLPLCGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSRTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEGQSLYVKGEPIINFYDPLVFPSDEFDASISQVNEKINQSLAFIRKSDELLHNVNAGKSTTNIMITTIIIVIIVILLSLIAVGLLLY
173. YK-RSV-053 mRNA, SEQ ID NO: 173
AGCGGCUCGGCCAUUUUGUCCCAGUCAGUCCGGAGGCUGCGGCUGCAGAAGUACCGCCUGCGGAGUAACUGCAAAGGCCACCAUGGAACUGCUGAUCCUGAAGGCCAACGCCAUCACCACCAUCCUGACCGCCGUGACCUUCUGUUUUGCCAGCGGCCAGAACAUCACCGAGGAAUUCUACCAGAGCACCUGUAGCGCCGUGUCCAAGGGAUAUCUGGGCGCCCUUAGAACCGGCUGGUACACCAGCGUGAUCACCAUCGAGCUGAGCAACAUCAAAGAAAACAAGUGCAACGGCACCGACGCCAAAGUGAAGCUGAUCAAGCAAGAGCUGGACAAGUACAAGAAUGCCGUGACCGACCUGCAGCUGCUGAUGCAGUCUACACCAGCCACAGGCUCUGGCAGCGCCAUUUGCUCUGGUGUCGCCGUGUCUAAAGUGCUGCACCUGGAAGGCGAAGUGAACAAGAUCAAGAGCGCCCUGCUGAGCACCAACAAGGCCGUGGUGUCUCUGAGCAAUGGCGUGUCCGUGCUGACCUUCAAGGUGCUGGACCUGAAGAACUACAUCGACAAACAGCUGCUGCCCAUCCUGAACAAGCAGUCCUGCAGCAUCCCCAACAUCGAGACAGUGAUCGAGUUCCAGCAGAAGAACAACCGGCUGCUGGAAAUCACCCGCGAGUUCUCUGUGAAUGCCGGCGUGACCACACCUGUGUCCACCUACAUGCUGACCAACAGCGAGCUGCUGAGCCUGAUCAACGACAUGCCCAUCACCAACGACCAGAAAAAGCUGAUGAGCAACAACGUGCAGAUCGUGCGGCAGCAGAGCUACAGCAUCAUGAGCAUUAUCAAAGAAGAGGUGCUGGCCUACGUGGUGCAGCUGCCUCUGUGCGGCGUGAUCGAUACCCCUUGCUGGAAGCUGCACACAAGCCCUCUGUGCACCACCAACACCAAAGAGGGCAGCAACAUCUGCCUGACCAGAACCGACAGAGGCUGGUACUGCGAUAAUGCCGGCAGCGUCUCAUUCUUCCCACAAGCCGAGACAUGCAAGGUGCAGAGCAACCGGGUGUUCUGCGACACCAUGAAUAGCAGAACCCUGCCUUCCGAAGUGAAUCUGUGCAACGUGGACAUCUUCAACCCUAAGUACGACUGCAAGAUCAUGACCAGCAAGACCGACGUGUCCAGCAGUGUGAUCACCUCACUGGGCGCCAUCGUGUCCUGUUACGGCAAGACCAAGUGCACCGCCAGCAACAAGAACCGGGGCAUCAUCAAGACCUUCAGCAACGGCUGCGACUACGUGUCCAACAAAGGCGUGGACACCGUGUCUGUGGGCAACACCCUGUACUACGUGAACAAACAAGAGGGCCAGUCUCUGUACGUGAAGGGCGAGCCCAUCAUCAACUUCUACGACCCUCUGGUGUUCCCCAGCGACGAGUUCGAUGCCAGCAUCAGCCAAGUGAACGAGAAGAUCAAUCAGAGCCUGGCCUUCAUCAGAAAGUCCGAUGAGCUGCUGCACAACGUGAACGCCGGCAAGUCCACCACCAAUAUCAUGAUCACGACCAUCAUCAUCGUGAUUAUCGUGAUCCUGCUGUCCCUGAUCGCCGUGGGCCUGCUGCUUUAUUGAUAAUAGGCUGGAGCCUCGGUGGCCAUGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCUUCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
174. YK-RSV-054 DNA, SEQ ID NO: 174
AGCGGCTCGGCCATTTTGTCCCAGTCAGTCCGGAGGCTGCGGCTGCAGAAGTACCGCCTGCGGAGTAACTGCAAAGGCCACCATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCAGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCAGCGCCTGCGCCTCTGGTGTCGCCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCCTGAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCTGCATGAGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTACGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCGACGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAGGCTGGAGCCTCGGTGGCCATGCTTCTTGCCCCTTGGGCCTCCCCCCAGCCCCTCCTCCCCTTCCTGCACCCGTACCCCCGTGGTCTTTGAATAAAGTCTGAGTGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
175. YK-RSV-054 ORF NT, SEQ ID NO: 175
ATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCAGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCAGCGCCTGCGCCTCTGGTGTCGCCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCCTGAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCTGCATGAGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTACGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCGACGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAG
176. YK-RSV-054 ORF AA, SEQ ID NO: 176
MELLILKANAITTILTAVTFCFASGQNITEEFYQSTCSAVSKGYLGALRTGWYTSVITIELSNIKENKCNGTDAKVKLIKQELDKYKNAVTDLQLLMQSTPATGSGSACASGVAVSKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTFKVLDLKNYIDKQLLPILNKQSCSIPNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSCMSIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSRTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEGQSLYVKGEPIINFYDPLVFPSDEFDASISQVNEKINQSLAFIRKSDELLHNVNAGKSTTNIMITTIIIVIIVILLSLIAVGLLLY
177. YK-RSV-054 mRNA, SEQ ID NO: 177
AGCGGCUCGGCCAUUUUGUCCCAGUCAGUCCGGAGGCUGCGGCUGCAGAAGUACCGCCUGCGGAGUAACUGCAAAGGCCACCAUGGAACUGCUGAUCCUGAAGGCCAACGCCAUCACCACCAUCCUGACCGCCGUGACCUUCUGUUUUGCCAGCGGCCAGAACAUCACCGAGGAAUUCUACCAGAGCACCUGUAGCGCCGUGUCCAAGGGAUAUCUGGGCGCCCUUAGAACCGGCUGGUACACCAGCGUGAUCACCAUCGAGCUGAGCAACAUCAAAGAAAACAAGUGCAACGGCACCGACGCCAAAGUGAAGCUGAUCAAGCAAGAGCUGGACAAGUACAAGAAUGCCGUGACCGACCUGCAGCUGCUGAUGCAGUCUACACCAGCCACAGGCUCUGGCAGCGCCUGCGCCUCUGGUGUCGCCGUGUCUAAAGUGCUGCACCUGGAAGGCGAAGUGAACAAGAUCAAGAGCGCCCUGCUGAGCACCAACAAGGCCGUGGUGUCUCUGAGCAAUGGCGUGUCCGUGCUGACCUUCAAGGUGCUGGACCUGAAGAACUACAUCGACAAACAGCUGCUGCCCAUCCUGAACAAGCAGUCCUGCAGCAUCCCCAACAUCGAGACAGUGAUCGAGUUCCAGCAGAAGAACAACCGGCUGCUGGAAAUCACCCGCGAGUUCUCUGUGAAUGCCGGCGUGACCACACCUGUGUCCACCUACAUGCUGACCAACAGCGAGCUGCUGAGCCUGAUCAACGACAUGCCCAUCACCAACGACCAGAAAAAGCUGAUGAGCAACAACGUGCAGAUCGUGCGGCAGCAGAGCUACAGCUGCAUGAGCAUUAUCAAAGAAGAGGUGCUGGCCUACGUGGUGCAGCUGCCUCUGUAUGGCGUGAUCGAUACCCCUUGCUGGAAGCUGCACACAAGCCCUCUGUGCACCACCAACACCAAAGAGGGCAGCAACAUCUGCCUGACCAGAACCGACAGAGGCUGGUACUGCGAUAAUGCCGGCAGCGUCUCAUUCUUCCCACAAGCCGAGACAUGCAAGGUGCAGAGCAACCGGGUGUUCUGCGACACCAUGAAUAGCAGAACCCUGCCUUCCGAAGUGAAUCUGUGCAACGUGGACAUCUUCAACCCUAAGUACGACUGCAAGAUCAUGACCAGCAAGACCGACGUGUCCAGCAGUGUGAUCACCUCACUGGGCGCCAUCGUGUCCUGUUACGGCAAGACCAAGUGCACCGCCAGCAACAAGAACCGGGGCAUCAUCAAGACCUUCAGCAACGGCUGCGACUACGUGUCCAACAAAGGCGUGGACACCGUGUCUGUGGGCAACACCCUGUACUACGUGAACAAACAAGAGGGCCAGUCUCUGUACGUGAAGGGCGAGCCCAUCAUCAACUUCUACGACCCUCUGGUGUUCCCCAGCGACGAGUUCGAUGCCAGCAUCAGCCAAGUGAACGAGAAGAUCAAUCAGAGCCUGGCCUUCAUCAGAAAGUCCGAUGAGCUGCUGCACAACGUGAACGCCGGCAAGUCCACCACCAAUAUCAUGAUCACGACCAUCAUCAUCGUGAUUAUCGUGAUCCUGCUGUCCCUGAUCGCCGUGGGCCUGCUGCUUUAUUGAUAAUAGGCUGGAGCCUCGGUGGCCAUGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCUUCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
178. YK-RSV-055 DNA, SEQ ID NO: 178
AGCGGCTCGGCCATTTTGTCCCAGTCAGTCCGGAGGCTGCGGCTGCAGAAGTACCGCCTGCGGAGTAACTGCAAAGGCCACCATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCAGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCAGCTGCATTGCCTCTGGTGTCGCCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCCTGAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGAGCATTTGCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTACGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCGACGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAGGCTGGAGCCTCGGTGGCCATGCTTCTTGCCCCTTGGGCCTCCCCCCAGCCCCTCCTCCCCTTCCTGCACCCGTACCCCCGTGGTCTTTGAATAAAGTCTGAGTGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
179. YK-RSV-055 ORF NT, SEQ ID NO: 179
ATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCAGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCAGCTGCATTGCCTCTGGTGTCGCCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCCTGAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGAGCATTTGCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTACGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCGACGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAG
180. YK-RSV-055 ORF AA, SEQ ID NO: 180
MELLILKANAITTILTAVTFCFASGQNITEEFYQSTCSAVSKGYLGALRTGWYTSVITIELSNIKENKCNGTDAKVKLIKQELDKYKNAVTDLQLLMQSTPATGSGSCIASGVAVSKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTFKVLDLKNYIDKQLLPILNKQSCSIPNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMSICKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSRTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEGQSLYVKGEPIINFYDPLVFPSDEFDASISQVNEKINQSLAFIRKSDELLHNVNAGKSTTNIMITTIIIVIIVILLSLIAVGLLLY
181. YK-RSV-055 mRNA, SEQ ID NO: 181
AGCGGCUCGGCCAUUUUGUCCCAGUCAGUCCGGAGGCUGCGGCUGCAGAAGUACCGCCUGCGGAGUAACUGCAAAGGCCACCAUGGAACUGCUGAUCCUGAAGGCCAACGCCAUCACCACCAUCCUGACCGCCGUGACCUUCUGUUUUGCCAGCGGCCAGAACAUCACCGAGGAAUUCUACCAGAGCACCUGUAGCGCCGUGUCCAAGGGAUAUCUGGGCGCCCUUAGAACCGGCUGGUACACCAGCGUGAUCACCAUCGAGCUGAGCAACAUCAAAGAAAACAAGUGCAACGGCACCGACGCCAAAGUGAAGCUGAUCAAGCAAGAGCUGGACAAGUACAAGAAUGCCGUGACCGACCUGCAGCUGCUGAUGCAGUCUACACCAGCCACAGGCUCUGGCAGCUGCAUUGCCUCUGGUGUCGCCGUGUCUAAAGUGCUGCACCUGGAAGGCGAAGUGAACAAGAUCAAGAGCGCCCUGCUGAGCACCAACAAGGCCGUGGUGUCUCUGAGCAAUGGCGUGUCCGUGCUGACCUUCAAGGUGCUGGACCUGAAGAACUACAUCGACAAACAGCUGCUGCCCAUCCUGAACAAGCAGUCCUGCAGCAUCCCCAACAUCGAGACAGUGAUCGAGUUCCAGCAGAAGAACAACCGGCUGCUGGAAAUCACCCGCGAGUUCUCUGUGAAUGCCGGCGUGACCACACCUGUGUCCACCUACAUGCUGACCAACAGCGAGCUGCUGAGCCUGAUCAACGACAUGCCCAUCACCAACGACCAGAAAAAGCUGAUGAGCAACAACGUGCAGAUCGUGCGGCAGCAGAGCUACAGCAUCAUGAGCAUUUGCAAAGAAGAGGUGCUGGCCUACGUGGUGCAGCUGCCUCUGUAUGGCGUGAUCGAUACCCCUUGCUGGAAGCUGCACACAAGCCCUCUGUGCACCACCAACACCAAAGAGGGCAGCAACAUCUGCCUGACCAGAACCGACAGAGGCUGGUACUGCGAUAAUGCCGGCAGCGUCUCAUUCUUCCCACAAGCCGAGACAUGCAAGGUGCAGAGCAACCGGGUGUUCUGCGACACCAUGAAUAGCAGAACCCUGCCUUCCGAAGUGAAUCUGUGCAACGUGGACAUCUUCAACCCUAAGUACGACUGCAAGAUCAUGACCAGCAAGACCGACGUGUCCAGCAGUGUGAUCACCUCACUGGGCGCCAUCGUGUCCUGUUACGGCAAGACCAAGUGCACCGCCAGCAACAAGAACCGGGGCAUCAUCAAGACCUUCAGCAACGGCUGCGACUACGUGUCCAACAAAGGCGUGGACACCGUGUCUGUGGGCAACACCCUGUACUACGUGAACAAACAAGAGGGCCAGUCUCUGUACGUGAAGGGCGAGCCCAUCAUCAACUUCUACGACCCUCUGGUGUUCCCCAGCGACGAGUUCGAUGCCAGCAUCAGCCAAGUGAACGAGAAGAUCAAUCAGAGCCUGGCCUUCAUCAGAAAGUCCGAUGAGCUGCUGCACAACGUGAACGCCGGCAAGUCCACCACCAAUAUCAUGAUCACGACCAUCAUCAUCGUGAUUAUCGUGAUCCUGCUGUCCCUGAUCGCCGUGGGCCUGCUGCUUUAUUGAUAAUAGGCUGGAGCCUCGGUGGCCAUGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCUUCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
182. YK-RSV-056 DNA, SEQ ID NO: 182
AGCGGCTCGGCCATTTTGTCCCAGTCAGTCCGGAGGCTGCGGCTGCAGAAGTACCGCCTGCGGAGTAACTGCAAAGGCCACCATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCAGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCAGCTGCATTGCCTCTGGTGTCGCCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCCTGAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACTGCATCATGAGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTACGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCGACGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAGGCTGGAGCCTCGGTGGCCATGCTTCTTGCCCCTTGGGCCTCCCCCCAGCCCCTCCTCCCCTTCCTGCACCCGTACCCCCGTGGTCTTTGAATAAAGTCTGAGTGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
183. YK-RSV-056 ORF NT, SEQ ID NO: 183
ATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCAGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCAGCTGCATTGCCTCTGGTGTCGCCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCCTGAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACTGCATCATGAGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTACGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCGACGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAG
184. YK-RSV-056 ORF AA, SEQ ID NO: 184
MELLILKANAITTILTAVTFCFASGQNITEEFYQSTCSAVSKGYLGALRTGWYTSVITIELSNIKENKCNGTDAKVKLIKQELDKYKNAVTDLQLLMQSTPATGSGSCIASGVAVSKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTFKVLDLKNYIDKQLLPILNKQSCSIPNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYCIMSIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSRTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEGQSLYVKGEPIINFYDPLVFPSDEFDASISQVNEKINQSLAFIRKSDELLHNVNAGKSTTNIMITTIIIVIIVILLSLIAVGLLLY
185. YK-RSV-056 mRNA, SEQ ID NO: 185
AGCGGCUCGGCCAUUUUGUCCCAGUCAGUCCGGAGGCUGCGGCUGCAGAAGUACCGCCUGCGGAGUAACUGCAAAGGCCACCAUGGAACUGCUGAUCCUGAAGGCCAACGCCAUCACCACCAUCCUGACCGCCGUGACCUUCUGUUUUGCCAGCGGCCAGAACAUCACCGAGGAAUUCUACCAGAGCACCUGUAGCGCCGUGUCCAAGGGAUAUCUGGGCGCCCUUAGAACCGGCUGGUACACCAGCGUGAUCACCAUCGAGCUGAGCAACAUCAAAGAAAACAAGUGCAACGGCACCGACGCCAAAGUGAAGCUGAUCAAGCAAGAGCUGGACAAGUACAAGAAUGCCGUGACCGACCUGCAGCUGCUGAUGCAGUCUACACCAGCCACAGGCUCUGGCAGCUGCAUUGCCUCUGGUGUCGCCGUGUCUAAAGUGCUGCACCUGGAAGGCGAAGUGAACAAGAUCAAGAGCGCCCUGCUGAGCACCAACAAGGCCGUGGUGUCUCUGAGCAAUGGCGUGUCCGUGCUGACCUUCAAGGUGCUGGACCUGAAGAACUACAUCGACAAACAGCUGCUGCCCAUCCUGAACAAGCAGUCCUGCAGCAUCCCCAACAUCGAGACAGUGAUCGAGUUCCAGCAGAAGAACAACCGGCUGCUGGAAAUCACCCGCGAGUUCUCUGUGAAUGCCGGCGUGACCACACCUGUGUCCACCUACAUGCUGACCAACAGCGAGCUGCUGAGCCUGAUCAACGACAUGCCCAUCACCAACGACCAGAAAAAGCUGAUGAGCAACAACGUGCAGAUCGUGCGGCAGCAGAGCUACUGCAUCAUGAGCAUUAUCAAAGAAGAGGUGCUGGCCUACGUGGUGCAGCUGCCUCUGUAUGGCGUGAUCGAUACCCCUUGCUGGAAGCUGCACACAAGCCCUCUGUGCACCACCAACACCAAAGAGGGCAGCAACAUCUGCCUGACCAGAACCGACAGAGGCUGGUACUGCGAUAAUGCCGGCAGCGUCUCAUUCUUCCCACAAGCCGAGACAUGCAAGGUGCAGAGCAACCGGGUGUUCUGCGACACCAUGAAUAGCAGAACCCUGCCUUCCGAAGUGAAUCUGUGCAACGUGGACAUCUUCAACCCUAAGUACGACUGCAAGAUCAUGACCAGCAAGACCGACGUGUCCAGCAGUGUGAUCACCUCACUGGGCGCCAUCGUGUCCUGUUACGGCAAGACCAAGUGCACCGCCAGCAACAAGAACCGGGGCAUCAUCAAGACCUUCAGCAACGGCUGCGACUACGUGUCCAACAAAGGCGUGGACACCGUGUCUGUGGGCAACACCCUGUACUACGUGAACAAACAAGAGGGCCAGUCUCUGUACGUGAAGGGCGAGCCCAUCAUCAACUUCUACGACCCUCUGGUGUUCCCCAGCGACGAGUUCGAUGCCAGCAUCAGCCAAGUGAACGAGAAGAUCAAUCAGAGCCUGGCCUUCAUCAGAAAGUCCGAUGAGCUGCUGCACAACGUGAACGCCGGCAAGUCCACCACCAAUAUCAUGAUCACGACCAUCAUCAUCGUGAUUAUCGUGAUCCUGCUGUCCCUGAUCGCCGUGGGCCUGCUGCUUUAUUGAUAAUAGGCUGGAGCCUCGGUGGCCAUGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCUUCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
186. YK-RSV-057 DNA, SEQ ID NO: 186
AGCGGCTCGGCCATTTTGTCCCAGTCAGTCCGGAGGCTGCGGCTGCAGAAGTACCGCCTGCGGAGTAACTGCAAAGGCCACCATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCAGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCAGCTGCATTGCCTCTGGTGTCGCCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCCTGAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGAGCTGCATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTACGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCGACGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAGGCTGGAGCCTCGGTGGCCATGCTTCTTGCCCCTTGGGCCTCCCCCCAGCCCCTCCTCCCCTTCCTGCACCCGTACCCCCGTGGTCTTTGAATAAAGTCTGAGTGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
187. YK-RSV-057 ORF NT, SEQ ID NO: 187
ATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCAGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCAGCTGCATTGCCTCTGGTGTCGCCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCCTGAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGAGCTGCATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTACGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCGACGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAG
188. YK-RSV-057 ORF AA, SEQ ID NO: 188
MELLILKANAITTILTAVTFCFASGQNITEEFYQSTCSAVSKGYLGALRTGWYTSVITIELSNIKENKCNGTDAKVKLIKQELDKYKNAVTDLQLLMQSTPATGSGSCIASGVAVSKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTFKVLDLKNYIDKQLLPILNKQSCSIPNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMSCIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSRTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEGQSLYVKGEPIINFYDPLVFPSDEFDASISQVNEKINQSLAFIRKSDELLHNVNAGKSTTNIMITTIIIVIIVILLSLIAVGLLLY
189. YK-RSV-057 mRNA, SEQ ID NO: 189
AGCGGCUCGGCCAUUUUGUCCCAGUCAGUCCGGAGGCUGCGGCUGCAGAAGUACCGCCUGCGGAGUAACUGCAAAGGCCACCAUGGAACUGCUGAUCCUGAAGGCCAACGCCAUCACCACCAUCCUGACCGCCGUGACCUUCUGUUUUGCCAGCGGCCAGAACAUCACCGAGGAAUUCUACCAGAGCACCUGUAGCGCCGUGUCCAAGGGAUAUCUGGGCGCCCUUAGAACCGGCUGGUACACCAGCGUGAUCACCAUCGAGCUGAGCAACAUCAAAGAAAACAAGUGCAACGGCACCGACGCCAAAGUGAAGCUGAUCAAGCAAGAGCUGGACAAGUACAAGAAUGCCGUGACCGACCUGCAGCUGCUGAUGCAGUCUACACCAGCCACAGGCUCUGGCAGCUGCAUUGCCUCUGGUGUCGCCGUGUCUAAAGUGCUGCACCUGGAAGGCGAAGUGAACAAGAUCAAGAGCGCCCUGCUGAGCACCAACAAGGCCGUGGUGUCUCUGAGCAAUGGCGUGUCCGUGCUGACCUUCAAGGUGCUGGACCUGAAGAACUACAUCGACAAACAGCUGCUGCCCAUCCUGAACAAGCAGUCCUGCAGCAUCCCCAACAUCGAGACAGUGAUCGAGUUCCAGCAGAAGAACAACCGGCUGCUGGAAAUCACCCGCGAGUUCUCUGUGAAUGCCGGCGUGACCACACCUGUGUCCACCUACAUGCUGACCAACAGCGAGCUGCUGAGCCUGAUCAACGACAUGCCCAUCACCAACGACCAGAAAAAGCUGAUGAGCAACAACGUGCAGAUCGUGCGGCAGCAGAGCUACAGCAUCAUGAGCUGCAUCAAAGAAGAGGUGCUGGCCUACGUGGUGCAGCUGCCUCUGUAUGGCGUGAUCGAUACCCCUUGCUGGAAGCUGCACACAAGCCCUCUGUGCACCACCAACACCAAAGAGGGCAGCAACAUCUGCCUGACCAGAACCGACAGAGGCUGGUACUGCGAUAAUGCCGGCAGCGUCUCAUUCUUCCCACAAGCCGAGACAUGCAAGGUGCAGAGCAACCGGGUGUUCUGCGACACCAUGAAUAGCAGAACCCUGCCUUCCGAAGUGAAUCUGUGCAACGUGGACAUCUUCAACCCUAAGUACGACUGCAAGAUCAUGACCAGCAAGACCGACGUGUCCAGCAGUGUGAUCACCUCACUGGGCGCCAUCGUGUCCUGUUACGGCAAGACCAAGUGCACCGCCAGCAACAAGAACCGGGGCAUCAUCAAGACCUUCAGCAACGGCUGCGACUACGUGUCCAACAAAGGCGUGGACACCGUGUCUGUGGGCAACACCCUGUACUACGUGAACAAACAAGAGGGCCAGUCUCUGUACGUGAAGGGCGAGCCCAUCAUCAACUUCUACGACCCUCUGGUGUUCCCCAGCGACGAGUUCGAUGCCAGCAUCAGCCAAGUGAACGAGAAGAUCAAUCAGAGCCUGGCCUUCAUCAGAAAGUCCGAUGAGCUGCUGCACAACGUGAACGCCGGCAAGUCCACCACCAAUAUCAUGAUCACGACCAUCAUCAUCGUGAUUAUCGUGAUCCUGCUGUCCCUGAUCGCCGUGGGCCUGCUGCUUUAUUGAUAAUAGGCUGGAGCCUCGGUGGCCAUGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCUUCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
190. YK-RSV-058 DNA, SEQ ID NO: 190
AGCGGCTCGGCCATTTTGTCCCAGTCAGTCCGGAGGCTGCGGCTGCAGAAGTACCGCCTGCGGAGTAACTGCAAAGGCCACCATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCAGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCAGCGCCATTGCCTCTGGTGTCGCCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCCTGAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGAGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCTGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTACGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGTGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCGACGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAGGCTGGAGCCTCGGTGGCCATGCTTCTTGCCCCTTGGGCCTCCCCCCAGCCCCTCCTCCCCTTCCTGCACCCGTACCCCCGTGGTCTTTGAATAAAGTCTGAGTGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
191. YK-RSV-058 ORF NT, SEQ ID NO: 191
ATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCAGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCAGCGCCATTGCCTCTGGTGTCGCCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCCTGAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGAGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCTGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTACGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGTGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCGACGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAG
192. YK-RSV-058 ORF AA, SEQ ID NO: 192
MELLILKANAITTILTAVTFCFASGQNITEEFYQSTCSAVSKGYLGALRTGWYTSVITIELSNIKENKCNGTDAKVKLIKQELDKYKNAVTDLQLLMQSTPATGSGSAIASGVAVSKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTFKVLDLKNYIDKQLLPILNKQSCSIPNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMSIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGCNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSRTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEGQSLYVKCEPIINFYDPLVFPSDEFDASISQVNEKINQSLAFIRKSDELLHNVNAGKSTTNIMITTIIIVIIVILLSLIAVGLLLY
193. YK-RSV-058 mRNA, SEQ ID NO: 193
AGCGGCUCGGCCAUUUUGUCCCAGUCAGUCCGGAGGCUGCGGCUGCAGAAGUACCGCCUGCGGAGUAACUGCAAAGGCCACCAUGGAACUGCUGAUCCUGAAGGCCAACGCCAUCACCACCAUCCUGACCGCCGUGACCUUCUGUUUUGCCAGCGGCCAGAACAUCACCGAGGAAUUCUACCAGAGCACCUGUAGCGCCGUGUCCAAGGGAUAUCUGGGCGCCCUUAGAACCGGCUGGUACACCAGCGUGAUCACCAUCGAGCUGAGCAACAUCAAAGAAAACAAGUGCAACGGCACCGACGCCAAAGUGAAGCUGAUCAAGCAAGAGCUGGACAAGUACAAGAAUGCCGUGACCGACCUGCAGCUGCUGAUGCAGUCUACACCAGCCACAGGCUCUGGCAGCGCCAUUGCCUCUGGUGUCGCCGUGUCUAAAGUGCUGCACCUGGAAGGCGAAGUGAACAAGAUCAAGAGCGCCCUGCUGAGCACCAACAAGGCCGUGGUGUCUCUGAGCAAUGGCGUGUCCGUGCUGACCUUCAAGGUGCUGGACCUGAAGAACUACAUCGACAAACAGCUGCUGCCCAUCCUGAACAAGCAGUCCUGCAGCAUCCCCAACAUCGAGACAGUGAUCGAGUUCCAGCAGAAGAACAACCGGCUGCUGGAAAUCACCCGCGAGUUCUCUGUGAAUGCCGGCGUGACCACACCUGUGUCCACCUACAUGCUGACCAACAGCGAGCUGCUGAGCCUGAUCAACGACAUGCCCAUCACCAACGACCAGAAAAAGCUGAUGAGCAACAACGUGCAGAUCGUGCGGCAGCAGAGCUACAGCAUCAUGAGCAUUAUCAAAGAAGAGGUGCUGGCCUACGUGGUGCAGCUGCCUCUGUAUGGCGUGAUCGAUACCCCUUGCUGGAAGCUGCACACAAGCCCUCUGUGCACCACCAACACCAAAGAGGGCUGCAACAUCUGCCUGACCAGAACCGACAGAGGCUGGUACUGCGAUAAUGCCGGCAGCGUCUCAUUCUUCCCACAAGCCGAGACAUGCAAGGUGCAGAGCAACCGGGUGUUCUGCGACACCAUGAAUAGCAGAACCCUGCCUUCCGAAGUGAAUCUGUGCAACGUGGACAUCUUCAACCCUAAGUACGACUGCAAGAUCAUGACCAGCAAGACCGACGUGUCCAGCAGUGUGAUCACCUCACUGGGCGCCAUCGUGUCCUGUUACGGCAAGACCAAGUGCACCGCCAGCAACAAGAACCGGGGCAUCAUCAAGACCUUCAGCAACGGCUGCGACUACGUGUCCAACAAAGGCGUGGACACCGUGUCUGUGGGCAACACCCUGUACUACGUGAACAAACAAGAGGGCCAGUCUCUGUACGUGAAGUGCGAGCCCAUCAUCAACUUCUACGACCCUCUGGUGUUCCCCAGCGACGAGUUCGAUGCCAGCAUCAGCCAAGUGAACGAGAAGAUCAAUCAGAGCCUGGCCUUCAUCAGAAAGUCCGAUGAGCUGCUGCACAACGUGAACGCCGGCAAGUCCACCACCAAUAUCAUGAUCACGACCAUCAUCAUCGUGAUUAUCGUGAUCCUGCUGUCCCUGAUCGCCGUGGGCCUGCUGCUUUAUUGAUAAUAGGCUGGAGCCUCGGUGGCCAUGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCUUCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
194. YK-RSV-059 DNA, SEQ ID NO: 194
AGCGGCTCGGCCATTTTGTCCCAGTCAGTCCGGAGGCTGCGGCTGCAGAAGTACCGCCTGCGGAGTAACTGCAAAGGCCACCATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCAGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCAGCGCCATTGCCTCTGGTGTCGCCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCCTGAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGAGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCTGCACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTACGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGTGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCGACGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAGGCTGGAGCCTCGGTGGCCATGCTTCTTGCCCCTTGGGCCTCCCCCCAGCCCCTCCTCCCCTTCCTGCACCCGTACCCCCGTGGTCTTTGAATAAAGTCTGAGTGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
195. YK-RSV-059 ORF NT, SEQ ID NO: 195
ATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCAGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCAGCGCCATTGCCTCTGGTGTCGCCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCCTGAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGAGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCTGCACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTACGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGTGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCGACGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAG
196. YK-RSV-059 ORF AA, SEQ ID NO: 196
MELLILKANAITTILTAVTFCFASGQNITEEFYQSTCSAVSKGYLGALRTGWYTSVITIELSNIKENKCNGTDAKVKLIKQELDKYKNAVTDLQLLMQSTPATGSGSAIASGVAVSKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTFKVLDLKNYIDKQLLPILNKQSCSIPNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMSIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTCTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSRTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEGQSLYVKCEPIINFYDPLVFPSDEFDASISQVNEKINQSLAFIRKSDELLHNVNAGKSTTNIMITTIIIVIIVILLSLIAVGLLLY
197. YK-RSV-059 mRNA, SEQ ID NO: 197
AGCGGCUCGGCCAUUUUGUCCCAGUCAGUCCGGAGGCUGCGGCUGCAGAAGUACCGCCUGCGGAGUAACUGCAAAGGCCACCAUGGAACUGCUGAUCCUGAAGGCCAACGCCAUCACCACCAUCCUGACCGCCGUGACCUUCUGUUUUGCCAGCGGCCAGAACAUCACCGAGGAAUUCUACCAGAGCACCUGUAGCGCCGUGUCCAAGGGAUAUCUGGGCGCCCUUAGAACCGGCUGGUACACCAGCGUGAUCACCAUCGAGCUGAGCAACAUCAAAGAAAACAAGUGCAACGGCACCGACGCCAAAGUGAAGCUGAUCAAGCAAGAGCUGGACAAGUACAAGAAUGCCGUGACCGACCUGCAGCUGCUGAUGCAGUCUACACCAGCCACAGGCUCUGGCAGCGCCAUUGCCUCUGGUGUCGCCGUGUCUAAAGUGCUGCACCUGGAAGGCGAAGUGAACAAGAUCAAGAGCGCCCUGCUGAGCACCAACAAGGCCGUGGUGUCUCUGAGCAAUGGCGUGUCCGUGCUGACCUUCAAGGUGCUGGACCUGAAGAACUACAUCGACAAACAGCUGCUGCCCAUCCUGAACAAGCAGUCCUGCAGCAUCCCCAACAUCGAGACAGUGAUCGAGUUCCAGCAGAAGAACAACCGGCUGCUGGAAAUCACCCGCGAGUUCUCUGUGAAUGCCGGCGUGACCACACCUGUGUCCACCUACAUGCUGACCAACAGCGAGCUGCUGAGCCUGAUCAACGACAUGCCCAUCACCAACGACCAGAAAAAGCUGAUGAGCAACAACGUGCAGAUCGUGCGGCAGCAGAGCUACAGCAUCAUGAGCAUUAUCAAAGAAGAGGUGCUGGCCUACGUGGUGCAGCUGCCUCUGUAUGGCGUGAUCGAUACCCCUUGCUGGAAGCUGCACACAAGCCCUCUGUGCACCACCUGCACCAAAGAGGGCAGCAACAUCUGCCUGACCAGAACCGACAGAGGCUGGUACUGCGAUAAUGCCGGCAGCGUCUCAUUCUUCCCACAAGCCGAGACAUGCAAGGUGCAGAGCAACCGGGUGUUCUGCGACACCAUGAAUAGCAGAACCCUGCCUUCCGAAGUGAAUCUGUGCAACGUGGACAUCUUCAACCCUAAGUACGACUGCAAGAUCAUGACCAGCAAGACCGACGUGUCCAGCAGUGUGAUCACCUCACUGGGCGCCAUCGUGUCCUGUUACGGCAAGACCAAGUGCACCGCCAGCAACAAGAACCGGGGCAUCAUCAAGACCUUCAGCAACGGCUGCGACUACGUGUCCAACAAAGGCGUGGACACCGUGUCUGUGGGCAACACCCUGUACUACGUGAACAAACAAGAGGGCCAGUCUCUGUACGUGAAGUGCGAGCCCAUCAUCAACUUCUACGACCCUCUGGUGUUCCCCAGCGACGAGUUCGAUGCCAGCAUCAGCCAAGUGAACGAGAAGAUCAAUCAGAGCCUGGCCUUCAUCAGAAAGUCCGAUGAGCUGCUGCACAACGUGAACGCCGGCAAGUCCACCACCAAUAUCAUGAUCACGACCAUCAUCAUCGUGAUUAUCGUGAUCCUGCUGUCCCUGAUCGCCGUGGGCCUGCUGCUUUAUUGAUAAUAGGCUGGAGCCUCGGUGGCCAUGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCUUCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
198. YK-RSV-060 DNA, SEQ ID NO: 198
AGCGGCTCGGCCATTTTGTCCCAGTCAGTCCGGAGGCTGCGGCTGCAGAAGTACCGCCTGCGGAGTAACTGCAAAGGCCACCATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCAGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCAGCGCCATTGCCTCTGGTGTCGCCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCCTGAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGAGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACTGCGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTGCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTACGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCGACGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAGGCTGGAGCCTCGGTGGCCATGCTTCTTGCCCCTTGGGCCTCCCCCCAGCCCCTCCTCCCCTTCCTGCACCCGTACCCCCGTGGTCTTTGAATAAAGTCTGAGTGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
199. YK-RSV-060 ORF NT, SEQ ID NO: 199
ATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCAGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCAGCGCCATTGCCTCTGGTGTCGCCGTGTCTAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCCTGAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGAGCATTATCAAAGAAGAGGTGCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACTGCGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTGCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTACGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCGACGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAG
200. YK-RSV-060 ORF AA, SEQ ID NO: 200
MELLILKANAITTILTAVTFCFASGQNITEEFYQSTCSAVSKGYLGALRTGWYTSVITIELSNIKENKCNGTDAKVKLIKQELDKYKNAVTDLQLLMQSTPATGSGSAIASGVAVSKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTFKVLDLKNYIDKQLLPILNKQSCSIPNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMSIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDCGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSRTLPCEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEGQSLYVKGEPIINFYDPLVFPSDEFDASISQVNEKINQSLAFIRKSDELLHNVNAGKSTTNIMITTIIIVIIVILLSLIAVGLLLY
201. YK-RSV-060 mRNA, SEQ ID NO: 201
AGCGGCUCGGCCAUUUUGUCCCAGUCAGUCCGGAGGCUGCGGCUGCAGAAGUACCGCCUGCGGAGUAACUGCAAAGGCCACCAUGGAACUGCUGAUCCUGAAGGCCAACGCCAUCACCACCAUCCUGACCGCCGUGACCUUCUGUUUUGCCAGCGGCCAGAACAUCACCGAGGAAUUCUACCAGAGCACCUGUAGCGCCGUGUCCAAGGGAUAUCUGGGCGCCCUUAGAACCGGCUGGUACACCAGCGUGAUCACCAUCGAGCUGAGCAACAUCAAAGAAAACAAGUGCAACGGCACCGACGCCAAAGUGAAGCUGAUCAAGCAAGAGCUGGACAAGUACAAGAAUGCCGUGACCGACCUGCAGCUGCUGAUGCAGUCUACACCAGCCACAGGCUCUGGCAGCGCCAUUGCCUCUGGUGUCGCCGUGUCUAAAGUGCUGCACCUGGAAGGCGAAGUGAACAAGAUCAAGAGCGCCCUGCUGAGCACCAACAAGGCCGUGGUGUCUCUGAGCAAUGGCGUGUCCGUGCUGACCUUCAAGGUGCUGGACCUGAAGAACUACAUCGACAAACAGCUGCUGCCCAUCCUGAACAAGCAGUCCUGCAGCAUCCCCAACAUCGAGACAGUGAUCGAGUUCCAGCAGAAGAACAACCGGCUGCUGGAAAUCACCCGCGAGUUCUCUGUGAAUGCCGGCGUGACCACACCUGUGUCCACCUACAUGCUGACCAACAGCGAGCUGCUGAGCCUGAUCAACGACAUGCCCAUCACCAACGACCAGAAAAAGCUGAUGAGCAACAACGUGCAGAUCGUGCGGCAGCAGAGCUACAGCAUCAUGAGCAUUAUCAAAGAAGAGGUGCUGGCCUACGUGGUGCAGCUGCCUCUGUAUGGCGUGAUCGAUACCCCUUGCUGGAAGCUGCACACAAGCCCUCUGUGCACCACCAACACCAAAGAGGGCAGCAACAUCUGCCUGACCAGAACCGACUGCGGCUGGUACUGCGAUAAUGCCGGCAGCGUCUCAUUCUUCCCACAAGCCGAGACAUGCAAGGUGCAGAGCAACCGGGUGUUCUGCGACACCAUGAAUAGCAGAACCCUGCCUUGCGAAGUGAAUCUGUGCAACGUGGACAUCUUCAACCCUAAGUACGACUGCAAGAUCAUGACCAGCAAGACCGACGUGUCCAGCAGUGUGAUCACCUCACUGGGCGCCAUCGUGUCCUGUUACGGCAAGACCAAGUGCACCGCCAGCAACAAGAACCGGGGCAUCAUCAAGACCUUCAGCAACGGCUGCGACUACGUGUCCAACAAAGGCGUGGACACCGUGUCUGUGGGCAACACCCUGUACUACGUGAACAAACAAGAGGGCCAGUCUCUGUACGUGAAGGGCGAGCCCAUCAUCAACUUCUACGACCCUCUGGUGUUCCCCAGCGACGAGUUCGAUGCCAGCAUCAGCCAAGUGAACGAGAAGAUCAAUCAGAGCCUGGCCUUCAUCAGAAAGUCCGAUGAGCUGCUGCACAACGUGAACGCCGGCAAGUCCACCACCAAUAUCAUGAUCACGACCAUCAUCAUCGUGAUUAUCGUGAUCCUGCUGUCCCUGAUCGCCGUGGGCCUGCUGCUUUAUUGAUAAUAGGCUGGAGCCUCGGUGGCCAUGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCUUCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
202. YK-RSV-061 DNA, SEQ ID NO: 202
AGCGGCTCGGCCATTTTGTCCCAGTCAGTCCGGAGGCTGCGGCTGCAGAAGTACCGCCTGCGGAGTAACTGCAAAGGCCACCATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCAGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCAGCGCCATTTGTTCTGGTATCGCCGTGTGCAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCGTCAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGTGCATTATCAAAGAAGAGATCCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTGCGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCAGCGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAGGCTGGAGCCTCGGTGGCCATGCTTCTTGCCCCTTGGGCCTCCCCCCAGCCCCTCCTCCCCTTCCTGCACCCGTACCCCCGTGGTCTTTGAATAAAGTCTGAGTGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
203. YK-RSV-061 ORF NT, SEQ ID NO: 203
ATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCAGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTGCAACGGCACCGACGCCAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAATGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCAGCGCCATTTGTTCTGGTATCGCCGTGTGCAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCGTCAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGTGCATTATCAAAGAAGAGATCCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTGCGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCAGCGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAG
204. YK-RSV-061 ORF AA, SEQ ID NO: 204
MELLILKANAITTILTAVTFCFASGQNITEEFYQSTCSAVSKGYLGALRTGWYTSVITIELSNIKENKCNGTDAKVKLIKQELDKYKNAVTDLQLLMQSTPATGSGSAICSGIAVCKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTFKVLDLKNYIDKQLLPIVNKQSCSIPNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMCIIKEEILAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSRTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYCVNKQEGQSLYVKGEPIINFYDPLVFPSSEFDASISQVNEKINQSLAFIRKSDELLHNVNAGKSTTNIMITTIIIVIIVILLSLIAVGLLLY
205. YK-RSV-061 mRNA, SEQ ID NO: 205
AGCGGCUCGGCCAUUUUGUCCCAGUCAGUCCGGAGGCUGCGGCUGCAGAAGUACCGCCUGCGGAGUAACUGCAAAGGCCACCAUGGAACUGCUGAUCCUGAAGGCCAACGCCAUCACCACCAUCCUGACCGCCGUGACCUUCUGUUUUGCCAGCGGCCAGAACAUCACCGAGGAAUUCUACCAGAGCACCUGUAGCGCCGUGUCCAAGGGAUAUCUGGGCGCCCUUAGAACCGGCUGGUACACCAGCGUGAUCACCAUCGAGCUGAGCAACAUCAAAGAAAACAAGUGCAACGGCACCGACGCCAAAGUGAAGCUGAUCAAGCAAGAGCUGGACAAGUACAAGAAUGCCGUGACCGACCUGCAGCUGCUGAUGCAGUCUACACCAGCCACAGGCUCUGGCAGCGCCAUUUGUUCUGGUAUCGCCGUGUGCAAAGUGCUGCACCUGGAAGGCGAAGUGAACAAGAUCAAGAGCGCCCUGCUGAGCACCAACAAGGCCGUGGUGUCUCUGAGCAAUGGCGUGUCCGUGCUGACCUUCAAGGUGCUGGACCUGAAGAACUACAUCGACAAACAGCUGCUGCCCAUCGUCAACAAGCAGUCCUGCAGCAUCCCCAACAUCGAGACAGUGAUCGAGUUCCAGCAGAAGAACAACCGGCUGCUGGAAAUCACCCGCGAGUUCUCUGUGAAUGCCGGCGUGACCACACCUGUGUCCACCUACAUGCUGACCAACAGCGAGCUGCUGAGCCUGAUCAACGACAUGCCCAUCACCAACGACCAGAAAAAGCUGAUGAGCAACAACGUGCAGAUCGUGCGGCAGCAGAGCUACAGCAUCAUGUGCAUUAUCAAAGAAGAGAUCCUGGCCUACGUGGUGCAGCUGCCUCUGUAUGGCGUGAUCGAUACCCCUUGCUGGAAGCUGCACACAAGCCCUCUGUGCACCACCAACACCAAAGAGGGCAGCAACAUCUGCCUGACCAGAACCGACAGAGGCUGGUACUGCGAUAAUGCCGGCAGCGUCUCAUUCUUCCCACAAGCCGAGACAUGCAAGGUGCAGAGCAACCGGGUGUUCUGCGACACCAUGAAUAGCAGAACCCUGCCUUCCGAAGUGAAUCUGUGCAACGUGGACAUCUUCAACCCUAAGUACGACUGCAAGAUCAUGACCAGCAAGACCGACGUGUCCAGCAGUGUGAUCACCUCACUGGGCGCCAUCGUGUCCUGUUACGGCAAGACCAAGUGCACCGCCAGCAACAAGAACCGGGGCAUCAUCAAGACCUUCAGCAACGGCUGCGACUACGUGUCCAACAAAGGCGUGGACACCGUGUCUGUGGGCAACACCCUGUACUGCGUGAACAAACAAGAGGGCCAGUCUCUGUACGUGAAGGGCGAGCCCAUCAUCAACUUCUACGACCCUCUGGUGUUCCCCAGCAGCGAGUUCGAUGCCAGCAUCAGCCAAGUGAACGAGAAGAUCAAUCAGAGCCUGGCCUUCAUCAGAAAGUCCGAUGAGCUGCUGCACAACGUGAACGCCGGCAAGUCCACCACCAAUAUCAUGAUCACGACCAUCAUCAUCGUGAUUAUCGUGAUCCUGCUGUCCCUGAUCGCCGUGGGCCUGCUGCUUUAUUGAUAAUAGGCUGGAGCCUCGGUGGCCAUGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCUUCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
206. YK-RSV-062 DNA, SEQ ID NO: 206
AGCGGCTCGGCCATTTTGTCCCAGTCAGTCCGGAGGCTGCGGCTGCAGAAGTACCGCCTGCGGAGTAACTGCAAAGGCCACCATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCAGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTACAACGGCACCGAGGTGAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAGCGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCAGCGCCATTTGTTCTGGTATCGCCGTGTGCAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCGTCAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGTGCATTATCAAAGAAGAGATCCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTGCGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCAGCGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAGGCTGGAGCCTCGGTGGCCATGCTTCTTGCCCCTTGGGCCTCCCCCCAGCCCCTCCTCCCCTTCCTGCACCCGTACCCCCGTGGTCTTTGAATAAAGTCTGAGTGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
207. YK-RSV-062 ORF NT, SEQ ID NO: 207
ATGGAACTGCTGATCCTGAAGGCCAACGCCATCACCACCATCCTGACCGCCGTGACCTTCTGTTTTGCCAGCGGCCAGAACATCACCGAGGAATTCTACCAGAGCACCTGTAGCGCCGTGTCCAAGGGATATCTGGGCGCCCTTAGAACCGGCTGGTACACCAGCGTGATCACCATCGAGCTGAGCAACATCAAAGAAAACAAGTACAACGGCACCGAGGTGAAAGTGAAGCTGATCAAGCAAGAGCTGGACAAGTACAAGAGCGCCGTGACCGACCTGCAGCTGCTGATGCAGTCTACACCAGCCACAGGCTCTGGCAGCGCCATTTGTTCTGGTATCGCCGTGTGCAAAGTGCTGCACCTGGAAGGCGAAGTGAACAAGATCAAGAGCGCCCTGCTGAGCACCAACAAGGCCGTGGTGTCTCTGAGCAATGGCGTGTCCGTGCTGACCTTCAAGGTGCTGGACCTGAAGAACTACATCGACAAACAGCTGCTGCCCATCGTCAACAAGCAGTCCTGCAGCATCCCCAACATCGAGACAGTGATCGAGTTCCAGCAGAAGAACAACCGGCTGCTGGAAATCACCCGCGAGTTCTCTGTGAATGCCGGCGTGACCACACCTGTGTCCACCTACATGCTGACCAACAGCGAGCTGCTGAGCCTGATCAACGACATGCCCATCACCAACGACCAGAAAAAGCTGATGAGCAACAACGTGCAGATCGTGCGGCAGCAGAGCTACAGCATCATGTGCATTATCAAAGAAGAGATCCTGGCCTACGTGGTGCAGCTGCCTCTGTATGGCGTGATCGATACCCCTTGCTGGAAGCTGCACACAAGCCCTCTGTGCACCACCAACACCAAAGAGGGCAGCAACATCTGCCTGACCAGAACCGACAGAGGCTGGTACTGCGATAATGCCGGCAGCGTCTCATTCTTCCCACAAGCCGAGACATGCAAGGTGCAGAGCAACCGGGTGTTCTGCGACACCATGAATAGCAGAACCCTGCCTTCCGAAGTGAATCTGTGCAACGTGGACATCTTCAACCCTAAGTACGACTGCAAGATCATGACCAGCAAGACCGACGTGTCCAGCAGTGTGATCACCTCACTGGGCGCCATCGTGTCCTGTTACGGCAAGACCAAGTGCACCGCCAGCAACAAGAACCGGGGCATCATCAAGACCTTCAGCAACGGCTGCGACTACGTGTCCAACAAAGGCGTGGACACCGTGTCTGTGGGCAACACCCTGTACTGCGTGAACAAACAAGAGGGCCAGTCTCTGTACGTGAAGGGCGAGCCCATCATCAACTTCTACGACCCTCTGGTGTTCCCCAGCAGCGAGTTCGATGCCAGCATCAGCCAAGTGAACGAGAAGATCAATCAGAGCCTGGCCTTCATCAGAAAGTCCGATGAGCTGCTGCACAACGTGAACGCCGGCAAGTCCACCACCAATATCATGATCACGACCATCATCATCGTGATTATCGTGATCCTGCTGTCCCTGATCGCCGTGGGCCTGCTGCTTTATTGATAATAG
208. YK-RSV-062 ORF AA, SEQ ID NO: 208
MELLILKANAITTILTAVTFCFASGQNITEEFYQSTCSAVSKGYLGALRTGWYTSVITIELSNIKENKYNGTEVKVKLIKQELDKYKSAVTDLQLLMQSTPATGSGSAICSGIAVCKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTFKVLDLKNYIDKQLLPIVNKQSCSIPNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMCIIKEEILAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSRTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYCVNKQEGQSLYVKGEPIINFYDPLVFPSSEFDASISQVNEKINQSLAFIRKSDELLHNVNAGKSTTNIMITTIIIVIIVILLSLIAVGLLLY
209. YK-RSV-062 mRNA, SEQ ID NO: 209
AGCGGCUCGGCCAUUUUGUCCCAGUCAGUCCGGAGGCUGCGGCUGCAGAAGUACCGCCUGCGGAGUAACUGCAAAGGCCACCAUGGAACUGCUGAUCCUGAAGGCCAACGCCAUCACCACCAUCCUGACCGCCGUGACCUUCUGUUUUGCCAGCGGCCAGAACAUCACCGAGGAAUUCUACCAGAGCACCUGUAGCGCCGUGUCCAAGGGAUAUCUGGGCGCCCUUAGAACCGGCUGGUACACCAGCGUGAUCACCAUCGAGCUGAGCAACAUCAAAGAAAACAAGUACAACGGCACCGAGGUGAAAGUGAAGCUGAUCAAGCAAGAGCUGGACAAGUACAAGAGCGCCGUGACCGACCUGCAGCUGCUGAUGCAGUCUACACCAGCCACAGGCUCUGGCAGCGCCAUUUGUUCUGGUAUCGCCGUGUGCAAAGUGCUGCACCUGGAAGGCGAAGUGAACAAGAUCAAGAGCGCCCUGCUGAGCACCAACAAGGCCGUGGUGUCUCUGAGCAAUGGCGUGUCCGUGCUGACCUUCAAGGUGCUGGACCUGAAGAACUACAUCGACAAACAGCUGCUGCCCAUCGUCAACAAGCAGUCCUGCAGCAUCCCCAACAUCGAGACAGUGAUCGAGUUCCAGCAGAAGAACAACCGGCUGCUGGAAAUCACCCGCGAGUUCUCUGUGAAUGCCGGCGUGACCACACCUGUGUCCACCUACAUGCUGACCAACAGCGAGCUGCUGAGCCUGAUCAACGACAUGCCCAUCACCAACGACCAGAAAAAGCUGAUGAGCAACAACGUGCAGAUCGUGCGGCAGCAGAGCUACAGCAUCAUGUGCAUUAUCAAAGAAGAGAUCCUGGCCUACGUGGUGCAGCUGCCUCUGUAUGGCGUGAUCGAUACCCCUUGCUGGAAGCUGCACACAAGCCCUCUGUGCACCACCAACACCAAAGAGGGCAGCAACAUCUGCCUGACCAGAACCGACAGAGGCUGGUACUGCGAUAAUGCCGGCAGCGUCUCAUUCUUCCCACAAGCCGAGACAUGCAAGGUGCAGAGCAACCGGGUGUUCUGCGACACCAUGAAUAGCAGAACCCUGCCUUCCGAAGUGAAUCUGUGCAACGUGGACAUCUUCAACCCUAAGUACGACUGCAAGAUCAUGACCAGCAAGACCGACGUGUCCAGCAGUGUGAUCACCUCACUGGGCGCCAUCGUGUCCUGUUACGGCAAGACCAAGUGCACCGCCAGCAACAAGAACCGGGGCAUCAUCAAGACCUUCAGCAACGGCUGCGACUACGUGUCCAACAAAGGCGUGGACACCGUGUCUGUGGGCAACACCCUGUACUGCGUGAACAAACAAGAGGGCCAGUCUCUGUACGUGAAGGGCGAGCCCAUCAUCAACUUCUACGACCCUCUGGUGUUCCCCAGCAGCGAGUUCGAUGCCAGCAUCAGCCAAGUGAACGAGAAGAUCAAUCAGAGCCUGGCCUUCAUCAGAAAGUCCGAUGAGCUGCUGCACAACGUGAACGCCGGCAAGUCCACCACCAAUAUCAUGAUCACGACCAUCAUCAUCGUGAUUAUCGUGAUCCUGCUGUCCCUGAUCGCCGUGGGCCUGCUGCUUUAUUGAUAAUAGGCUGGAGCCUCGGUGGCCAUGCUUCUUGCCCCUUGGGCCUCCCCCCAGCCCCUCCUCCCCUUCCUGCACCCGUACCCCCGUGGUCUUUGAAUAAAGUCUGAGUGGGCGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
210. RSV A2 (138251)-mt SEQ ID NO: 210
MELLILKANAITTILTAVTFCFASGQNITEEFYQSTCSAVSKGYLSALRTGWYTSVITIELSNIKENKCNGTDAKVKLIKQELDKYKNAVTELQLLMQSTPATNNRARRELPRFMNYTLNNAKKTNVTLSKKRKRRFLGFLLGVGSAIASGVAVSKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTSKVLDLKNYIDKQLLPIVNKQSCSISNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMSIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSLTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEGKSLYVKGEPIINFYDPLVFPSDEFDASISQVNEKINQSLAFIRKSDELLHNVNAGKSTTNIMITTIIIVIIVILLSLIAVGLLLYCKARSTPVTLSKDQLSGINNIAFSN
211. PC-RSV-063 SEQ ID NO: 211
MELLILKANAITTILTAVTFCFASGQNITEEFYQSTCSAVSKGYLGALRTGWYTSVITIELSNIKENKCNGTDAKVKLIKQELDKYKNAVTDLQLLMQSTPATGSGSAICSGVAVCKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTFKVLDLKNYIDKQLLPILNKQSCSIPNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMCIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSRTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYCVNKQEGQSLYVKGEPIINFYDPLVFPSDEFDASISQVNEKINQSLAFIRKSDELLHNVNAGKSTTNIMITTIIIVIIVILLSLIAVGLLLY
212. PC-RSV-064 SEQ ID NO: 212
MELLILKANAITTILTAVTFCFASGQNITEEFYQSTCSAVSKGYLGALRTGWYTSVITIELSNIKENKCNGTDAKVKLIKQELDKYKNAVTDLQLLMQSTPATGSGSAICSGIAVCKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTFKVLDLKNYIDKQLLPIVNKQSCSIPNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMCIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSRTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYCVNKQEGQSLYVKGEPIINFYDPLVFPSDEFDASISQVNEKINQSLAFIRKSDELLHNVNAGKSTTNIMITTIIIVIIVILLSLIAVGLLLY
213. PC-RSV-065 SEQ ID NO: 213
MELLILKANAITTILTAVTFCFASGQNITEEFYQSTCSAVSKGYLGALRTGWYTSVITIELSNIKENKCNGTDAKVKLIKQELDKYKNAVTDLQLLMQSTPATGSGSAICSGIAVCKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTFKVLDLKNYIDKQLLPIVNKQSCSIPNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMCIIKEEILAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSRTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYCVNKQEGQSLYVKGEPIINFYDPLVFPSDEFDASISQVNEKINQSLAFIRKSDELLHNVNAGKSTTNIMITTIIIVIIVILLSLIAVGLLLY
214. PC-RSV-066 SEQ ID NO: 214
MELLILKANAITTILTAVTFCFASGQNITEEFYQSTCSAVSKGYLGALRTGWYTSVITIELSNIKENKCNGTDAKVKLIKQELDKYKNAVTDLQLLMQSTPATGSGSAICSGIAVCKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTFKVLDLKNYIDKQLLPIVNKQSCSIPNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMCIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSRTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYCVNKQEGQSLYVKGEPIINFYDPLVFPSSEFDASISQVNEKINQSLAFIRKSDELLHNVNAGKSTTNIMITTIIIVIIVILLSLIAVGLLLY
215. PC-RSV-067 SEQ ID NO: 215
MELLILKANAITTILTAVTFCFASGQNITEEFYQSTCSAVSKGYLGALRTGWYTSVITIELSNIKENKCNGTDAKVKLIKQELDKYKNAVTDLQLLMQSTPACGSGSACASGIAVSKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTFKVLDLKNYIDKQLLPIVNKQSCSIPNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMSIIKEEILAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSRTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEGQSLYVKGEPIINFYDPLVFPSSEFDASISQVNEKINQSLAFIRKSDELLHNVNAGKSTTNIMITTIIIVIIVILLSLIAVGLLLY
216. PC-RSV-068 SEQ ID NO: 216
MELLILKANAITTILTAVTFCFASGQNITEEFYQSTCSAVSKGYLGALRTGWYTCVITIELSNIKENKCNGTDAKVKLIKQELDKYKNAVTDLQLLMQSTPATGSGSAIASGIAVSKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVCTFKVLDLKNYIDKQLLPIVNKQSCSIPNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMSIIKEEILAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSRTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEGQSLYVKGEPIINFYDPLVFPSSEFDASISQVNEKINQSLAFIRKSDELLHNVNAGKSTTNIMITTIIIVIIVILLSLIAVGLLLY
217. 5’ UTR SEQ ID NO: 217
5’AGCGGCTCGGCCATTTTGTCCCAGTCAGTCCGGAGGCTGCGGCTGCAGAAGTACCGCCTGCGGAGTAACTGCAAAGGCCACC3’
218. 5’ UTR SEQ ID NO: 218
5’AGACTCCTCCCCATCCTCTCCCTCTGTCCCTCTGTCCCTCTGACCCTGCACTGTCCCAGCACCGCCACC3’
219. 5’ UTR SEQ ID NO: 219
5’GGGAAATAAGAGAGAAAAGAAGAGTAAGAAGAAATATAAGACCCCGGCGCCGCCACC3’
220. 5’ UTR SEQ ID NO: 220
5’GAGAATAAACTAGTATTCTTCTGGTCCCCACAGACTCAGAGAGAACCCGCCACC3’
221. 5’ UTR SEQ ID NO: 221
5'GGGAAATAAGAGAGAAAAGAAGAGTAAGAAGAAATATAAGAGCCACC3’
222. 3’ UTR SEQ ID NO: 222
5’GCTGGAGCCTCGGTGGCCATGCTTCTTGCCCCTTGGGCCTCCCCCCAGCCCCTCCTCCCCTTCCTGCACCCGTACCCCCGTGGTCTTTGAATAAAGTCTGAGTGGGCGGC3’；
223. 3’ UTR SEQ ID NO: 223
5’GCTGGAGCCTCGGTGGCCTAGCTTCTTGCCCCTTGGGCCTCCCCCCAGCCCCTCCTCCCCTTCCTGCACCCGTACCCCCGTGGTCTTTGAATAAAGTCTGAGTGGGCGGC3’；
224. 3’ UTR SEQ ID NO: 224
5’CTCGAGCTGGTACTGCATGCACGCAATGCTAGCTGCCCCTTTCCCGTCCTGGGTACCCCGAGTCTCCCCCGACCTCGGGTCCCAGGTATGCTCCCACCTCCACCTGCCCCACTCACCACCTCTGCTAGTTCCAGACACCTCCCAAGCACGCAGCAATGCAGCTCAAAACGCTTAGCCTAGCCACACCCCCACGGGAAACAGCAGTGATTAACCTTTAGCAATAAACGAAAGTTTAACTAAGCTATACTAACCCCAGGGTTGGTCAATTTCGTGCCAGCCACACCCTGGAGCTAGC3’；
225. 3’ UTR SEQ ID NO: 225
5’TGATAATAGGCTGGAGCCTCGGTGGCCATGCTTCTTGCCCCTTGGGCCTCCCCCCAGCCCCTCCTCCCCTTCCTGCACCCGTACCCCCGTGGTCTTTGAATAAAGTCTGA3’。

Claims (71)

1.一种免疫原性组合物，包含呼吸道合胞病毒（RSV）的核糖核酸（RNA），所述RNA编码野生型RSV F蛋白或其变体；
其中所述野生型RSV F蛋白的序列为SEQ ID NO:1。
2.如权利要求1所述的组合物，其中所述RSV F蛋白变体包含选自以下的一种或更多种突变形式：序列截短、序列缺失和位点突变。
3.如权利要求2所述的组合物，其中所述序列截短包括缺少细胞质结构域。
4.如权利要求2或3所述的组合物，其中，所述序列缺失选自以下一种或更多种：第104-136位氨基酸缺失和104-144位氨基酸缺失；任选地，所述序列缺失的氨基酸由GSGS短肽或GS短肽替代。
5.如权利要求2或3所述的组合物，其中所述位点突变包括选自以下的一种或更多种：P102A、I379V和M447V。
6.如权利要求5所述的组合物，其中所述位点突变还包括选自以下的一种或更多种：S46G、S215P、L373R、S213P和N216P。
7.如权利要求5所述的组合物，其中所述位点突变还包括选自以下的任意一种或更多种：
(i) Q26C、N27C、T29C、E31C、F32C、Q34C、T36C、S41C、Y44C、Y53C、T54C、S55C、T100C、T103C、L138C、G139C、F140C、L141C、L142C、G145C、S146C、A147C、I148C、A149C、S150C、V152C、A153C、V154C、S155C、N183GC、S186C、L188C、S287C、I288C、S290C、I291C、I292C、V300C、L305C、Y306C、S319C、N325C、S330C、T337C、R339C、Q354C、T369C、M370C、N371C、S377C、N428C、Y458C、K461C、Q462C、K465C、L467C、Y468C、K470C、G471C；
(ii) T54H、T58L、S190I、S190F、V207L、T219I、V296I；
(iii) E92D、K465Q、D486S；和
(iv) V152I、C69Y、D73E、A74V、N88S。
8.如权利要求5所述的组合物，其中所述位点突变还包括选自以下的任意一个或更多个组合：
(i) E31C、Q34C、T54C、S55C、T100C、I148C、A149C、V152C、V154C、S155C、L188C、I288C、S290C、R339C、S377C、Y458C、L467C、G471C；
(ii) S190F、V296I、V207L、T219I、S190I；
(iii) E92D、K465Q、D486S；和
(iv) V152I、C69Y、D73E、A74V、N88S。
9.如权利要求5所述的组合物，其中所述位点突变还包括选自以下中的任意一个或更多个组合：
(i) T54C、S55C、T100C、I148C、A149C、V152C、V154C、S155C、L188C、I288C、S290C、R339C、S377C、Y458C；
(ii) S190F、V296I、V207L、T219I、S190I；
(iii) E92D、K465Q、D486S；和
(iv) V152I、C69Y、D73E、A74V、N88S。
10.如权利要求5所述的组合物，其中所述位点突变还包括选自以下的任意一个或更多个组合：
(i) T54C、I148C、A149C、V152C、S155C、I288C、S290C、Y458C；
(ii) S190F、V296I、V207L；
(iii) E92D、K465Q、D486S；和
(iv) V152I、C69Y、D73E、A74V、N88S。
11.如权利要求5所述的组合物，其中所述RSV F蛋白变体包含P102A、I379V和M447V突变，所述RSV F蛋白变体为SEQ ID NO:1中第550-574位氨基酸被截掉后的截短蛋白，并且第104-144位氨基酸被替换为GS接头，同时所述RSV F蛋白变体还包含选自以下任意一组的位点突变组合：
。
12.如权利要求5所述的组合物，其中所述RSV F蛋白变体包含P102A、I379V和M447V突变，所述RSV F蛋白变体为SEQ ID NO:1中第550-574位氨基酸被截掉后的截短蛋白，并且第104-144位氨基酸被替换为GS接头，同时所述RSV F蛋白变体还包含选自以下任意一组位点突变组合：
。
13.如权利要求5所述的组合物，其中所述RSV F蛋白变体包含P102A、I379V和M447V突变，所述RSV F蛋白变体为SEQ ID NO:1中第550-574位氨基酸被截掉后的截短蛋白，并且第104-144位氨基酸被替换为GS接头，同时所述RSV F蛋白变体还包含选自以下任意一组的突变组合：
。
14.如权利要求5所述的组合物，其中所述RSV F蛋白的变体包含与SEQ ID NO: 204、SEQ ID NO: 12、SEQ ID NO: 208、SEQ ID NO: 176、SEQ ID NO: 116、SEQ ID NO: 136、SEQID NO: 40、SEQ ID NO: 52、SEQ ID NO: 4、SEQ ID NO: 104、SEQ ID NO: 200、SEQ ID NO:36或SEQ ID NO: 80的序列具有至少80%、85%、90%、95%或至少98%或100%同一性的氨基酸序列。
15.如权利要求14所述的组合物，其中所述RSV F蛋白的变体包含与SEQ ID NO: 204、SEQ ID NO: 12、SEQ ID NO: 208、SEQ ID NO: 176、SEQ ID NO: 116、SEQ ID NO: 136、SEQID NO: 40、SEQ ID NO: 52、SEQ ID NO: 4、SEQ ID NO: 104或SEQ ID NO: 200的序列具有至少80%、85%、90%、95%或至少98%或100%同一性的氨基酸序列。
16.如权利要求15所述的组合物，其中，所述RSV F蛋白的变体包含与SEQ ID NO: 204、SEQ ID NO: 12、SEQ ID NO: 208、SEQ ID NO: 176或SEQ ID NO: 116的序列具有至少80%、85%、90%、95%或至少98%或100%同一性的氨基酸序列。
17.如权利要求5所述的组合物，其中编码所述RSV F蛋白或其变体的开放阅读框（ORF）包含与SEQ ID NO: 203、SEQ ID NO: 11、SEQ ID NO: 207、SEQ ID NO: 175、SEQ ID NO:115、SEQ ID NO: 135、SEQ ID NO: 39、SEQ ID NO: 51、SEQ ID NO: 3、SEQ ID NO: 103、SEQ ID NO: 199、SEQ ID NO: 35或SEQ ID NO: 79具有至少80%、85%、90％、95%或至少98%或100%同一性的核苷酸序列。
18.如权利要求17所述的组合物，其中所述ORF包含与SEQ ID NO: 203、SEQ ID NO:11、SEQ ID NO: 207、SEQ ID NO: 175、SEQ ID NO: 115、SEQ ID NO: 135、SEQ ID NO: 39、SEQ ID NO: 51、SEQ ID NO: 3、SEQ ID NO: 103或SEQ ID NO: 199具有至少80%、85%、90%、95%或至少98%或100%同一性的核苷酸序列。
19.如权利要求18所述的组合物，其中所述ORF包含与SEQ ID NO: 203、SEQ ID NO:11、SEQ ID NO: 207、SEQ ID NO: 175或SEQ ID NO: 115具有至少80%、85%、90%、95%或至少98%或100%同一性的核苷酸序列。
20.如权利要求5所述的组合物，其中所述RSV的RNA还包含5′非翻译区（UTR）。
21.如权利要求20所述的组合物，其中所述5′非翻译区的序列为：SEQ ID NO:217、SEQID NO:218、SEQ ID NO:219、SEQ ID NO:220或SEQ ID NO:221。
22.如权利要求21所述的组合物，其中所述5′非翻译区的序列为SEQ ID NO:217。
23.如权利要求5所述的组合物，其中所述RSV的RNA还包含3′非翻译区（UTR）。
24.如权利要求23所述的组合物，其中所述3′非翻译区的序列为：SEQ ID NO:222、SEQID NO:223、SEQ ID NO:224或SEQ ID NO:225。
25.如权利要求24所述的组合物，其中所述3′非翻译区的序列为SEQ ID NO:222。
26.如权利要求5所述的组合物，其中所述RSV的RNA还包含poly(A)尾。
27.如权利要求26所述的组合物，其中所述Ploy(A)尾的长度为50~150个核苷酸。
28.如权利要求5所述的组合物，其中所述RSV的RNA还包含5′端帽子结构。
29.如权利要求28所述的组合物，其中所述5′端帽子结构为：7mG(5′)ppp(5′)NlmpNp。
30.如权利要求5所述的组合物，其中所述RSV RNA中编码所述RSV F蛋白或其变体的开放阅读框（ORF）的序列是经过密码子优化的。
31.如权利要求30所述的组合物，其中所述ORF的序列包含至少一种碱基修饰。
32.如权利要求31所述的组合物，其中所述碱基修饰包括选自以下的任意一种或更多种：假尿苷、N1-甲基假尿苷、N1-乙基假尿苷、2-硫尿苷、4′-硫尿苷、5-甲基胞嘧啶、2-硫基-1-甲基-1-去氮杂-假尿苷、2-硫基-1-甲基-假尿苷、2-硫基-5-氮杂-尿苷、2-硫基-二氢假尿苷、2-硫基-二氢尿苷、2-硫基-假尿苷、4-甲氧基-2-硫基-假尿苷、4-甲氧基-假尿苷、4-硫基-1-甲基-假尿苷、4-硫基-假尿苷、5-氮杂-尿苷、二氢假尿苷、5-甲氧基尿苷和2′-O-甲基尿苷。
33.如权利要求32所述的组合物，其中所述碱基修饰包括将尿嘧啶以假尿苷和/或N1-甲基假尿苷替代。
34.如权利要求31所述的组合物，其中所述碱基修饰是1%~100%碱基修饰。
35. 如权利要求5所述的组合物，其中所述RSV的RNA的序列与SEQ ID NO: 205、SEQ IDNO: 13、SEQ ID NO: 209、SEQ ID NO: 177、SEQ ID NO: 117、SEQ ID NO: 137、SEQ ID NO:41、SEQ ID NO: 53、SEQ ID NO: 5、SEQ ID NO: 105、SEQ ID NO: 201、SEQ ID NO: 37或SEQ ID NO: 81具有至少80%、85%、90%、95%或至少98%或100%的同一性。
36.如权利要求35所述的组合物，其中所述RSV的RNA的序列与SEQ ID NO: 205、SEQ IDNO: 13、SEQ ID NO: 209、SEQ ID NO: 177、SEQ ID NO: 117、SEQ ID NO: 137、SEQ ID NO:41、SEQ ID NO: 53、SEQ ID NO: 5、SEQ ID NO: 105或SEQ ID NO: 201具有至少80%、85%、90%、95%或至少98%或100%的同一性。
37. 如权利要求36所述的组合物，其中所述RSV的RNA的序列与SEQ ID NO: 205、SEQID NO:13、SEQ ID NO:209、SEQ ID NO:177或SEQ ID NO:117具有至少80%、85%、90%、95%或至少98%或100%的同一性。
38.如权利要求5所述的组合物，其中所述RSV的RNA为mRNA。
39. 如权利要求5所述的组合物，其中编码所述RSV F蛋白或其变体的序列与SEQ IDNO:202、SEQ ID NO:10、SEQ ID NO:206、SEQ ID NO:174、SEQ ID NO:114、SEQ ID NO:134、SEQ ID NO:38、SEQ ID NO:50、SEQ ID NO:2、SEQ ID NO:102、SEQ ID NO: 198、SEQ ID NO:34或SEQ ID NO:78具有至少80%、85%、90%、95%或至少98%或100%的同一性。
40.如权利要求39所述的组合物，其中编码所述RSV F蛋白或其变体的序列与SEQ IDNO: 202、SEQ ID NO:10、SEQ ID NO:206、SEQ ID NO:174、SEQ ID NO:114、SEQ ID NO:134、SEQ ID NO:38、SEQ ID NO:50、SEQ ID NO:2、SEQ ID NO:102或SEQ ID NO:198具有至少80%、85%、90%、95%或至少98%或100%的同一性。
41. 如权利要求40所述的组合物，其中编码所述RSV F蛋白或其变体的序列与SEQ IDNO:202、SEQ ID NO:10、SEQ ID NO:206、SEQ ID NO:174或SEQ ID NO:114具有至少80%、85%、90%、95%或至少98%或100%的同一性。
42.制备如权利要求1至41中任一项所述组合物的方法，包括：
提供可转录出所述RSV之RNA的模板；
在适于转录所述RNA的条件下，利用所述模板进行转录。
43.根据权利要求42所述的方法，其还包括选自以下的纯化步骤：氯化锂沉淀、亲和层析、超滤换液、纤维素层析。
44.根据权利要求5所述的组合物，其是疫苗，并且还包含可药用载剂。
45.如权利要求44所述的组合物，其中所述可药用载剂包含脂质混合物，所述脂质混合物为脂质纳米颗粒（LNP）。
46.如权利要求44所述的组合物，其中所述疫苗为mRNA疫苗。
47. 如权利要求45所述的组合物，其中所述脂质纳米颗粒包含阳离子脂质、中性脂质、结构性脂质和聚合物共轭脂质。
48.如权利要求47所述的组合物，其中所述阳离子脂质是式I结构的化合物，或其N-氧化物、溶剂合物、药学上可接受的盐或立体异构体，其中G1为C1～6亚烷基；G2为C2～8亚烷基；G3为C1～3亚烷基；L1为C6～15直链烷基；L2为C12～25支链烷基
。
49.如权利要求47所述的组合物，其中所述阳离子脂质是式II结构的化合物，或其N-氧化物、溶剂合物、药学上可接受的盐或立体异构体，其中G1为C2~8亚烷基；G2为C2~8亚烷基；L1为-C(O)O-或-OC(O)-；L2为-C(O)O-或-OC(O)-；R1为C6~25直链或支链烷基；R2为C6~25直链或支链烷基；G3为HO(CH2)2-或HO(CH2)3-；G4为HO(CH2)2-或HO(CH2)3-；L为(CH2)2-或-(CH2)3-或-(CH2)4-
。
50.如权利要求47所述的组合物，其中所述阳离子脂质是式III结构的化合物，或其N-氧化物、溶剂合物、药学上可接受的盐或立体异构体，其中G1为C1~6亚烷基；G2为C2~8亚烷基；R1为C6~20直链或支链烷基；R2为C12~25支链烷基；G3为：HO(CH2)2N(CH3)(CH2)2-，HO(CH2)2N(CH2CH3)(CH2)2-，(HO(CH2)2)2N(CH2)2-，CH3O(CH2)2N(CH3)(CH2)2-，(CH3)2N(CH2)3SC(O)O(CH2)2-，(CH3)2N(CH2)3SC(O)-，CH3NH(CH2)2N(CH3)(CH2)2-或CH3CH2NH(CH2)2-
。
51.如权利要求47所述的组合物，其中所述阳离子脂质是式IV结构的化合物，或其N-氧化物、溶剂合物、药学上可接受的盐或立体异构体，其中G1为C1~8亚烷基；G2为C2~8亚烷基；R1为C6~25直链或支链烷基；R2为C12~25直链或支链烷基；G3为HO(CH2)2N(R3)CH2CH(OH)CH2-，其中R3为-CH3或-CH2CH3或-CH2CH2OH
。
52.如权利要求47所述的组合物，其中所述阳离子脂质是式V结构的化合物，或其N-氧化物、溶剂合物、药学上可接受的盐或立体异构体，其中，G1和G2各自独立地为未取代的C6-C10亚烷基；G3为未取代的C1-C12亚烷基；R1和R2各自独立地为C6-C24烷基或C6-C24烯基；R3为OR5、N、 -C(＝O)OR4、 -OC(＝O)R4或-NR5C(＝O)R4；R4为C1-C12烷基；并且R5为H或C1-C6烷基
。
53.如权利要求47所述的组合物，其中所述阳离子脂质是式VI结构的化合物，或其N-氧化物、溶剂合物、药学上可接受的盐或立体异构体，其中，R4选自-(CH2)nQ和-(CH2)nCHQR；Q选自由以下组成的组：-OR、-OH、-O(CH2)nN(R)2、-OC(O)R、-CX3、-CN、-N(R)C(O)R、-N(H)C(O)R、-N(R)S(O)2R、-N(H)S(O)2R、-N(R)C(O)N(R)2、-N(H)C(O)N(R)2、-N(H)C(O)N(H)(R)、-N(R)C(S)N(R)2、-N(H)C(S)N(R)2、-N(H)C(S)N(H)(R)、-N(R)S(O)2R8和杂环；n是1、2或3；其中R为氢、C1~3烷基、C2~3烯基或(CH2)qOR*，其中q为1、2或3，R*为C1~12烷基或C2~12烯基；X为氟、氯、溴或碘；R8为C3~6环烷基或杂环
。
54.如权利要求47所述的组合物，其中所述阳离子脂质是式VII结构的化合物，或其N-氧化物、溶剂合物、药学上可接受的盐或立体异构体：
。
55.如前述权利要求47所述的组合物，其中所述阳离子脂质选自以下化合物：YK-009、YK-401、YK-305、ALC0315、SM102、DLIN-MC3
。
56.如权利要求47所述的组合物，其中所述阳离子脂质与所述中性脂质的摩尔比为（1～10）：1。
57.如权利要求47所述的组合物，其中所述阳离子脂质与所述结构性脂质的摩尔比为（1～5）：1。
58.如权利要求47所述的组合物，其中所述阳离子脂质、所述中性脂质、所述结构性脂质以及所述聚合物共轭脂质的摩尔比为（25～75）：（5～25）：（15～65）：（0.5～10）。
59.如权利要求58所述的组合物，其中所述阳离子脂质、所述中性脂质、所述结构性脂质以及所述聚合物共轭脂质的摩尔比为（35~49）：（7.5~15）：（35~55）：（1~5）。
60.如权利要求47所述的组合物，其中所述中性脂质选自磷脂酰胆碱、磷脂酰乙醇胺、鞘磷脂、神经酰胺、甾醇及其衍生物中的一种或更多种。
61. 如权利要求47所述的组合物，其中所述中性脂质选自以下中的一种或更多种：1,2-二亚油酰基-sn-甘油-3-磷酸胆碱(DLPC)、1,2-二肉豆蔻酰基-sn-甘油-磷酸胆碱(DMPC)、1,2-二油酰基-sn-甘油-3-磷酸胆碱(DOPC)、1,2-二棕榈酰基-sn-甘油-3-磷酸胆碱(DPPC)、1,2-二硬脂酰基-sn-甘油-3-磷酸胆碱(DSPC)、1,2-双十一烷酰基-sn-甘油-磷酸胆碱(DUPC)、1-棕榈酰基-2-油酰基-sn-甘油-3-磷酸胆碱(POPC)、1,2-二-O-十八碳烯基-sn-甘油-3-磷酸胆碱(18:0Diether PC)、1-油酰基-2-胆固醇基半琥珀酰基-sn-甘油-3-磷酸胆碱(OChemsPC)、1-十六烷基-sn-甘油-3-磷酸胆碱(C16 Lyso PC)、1,2-二亚麻酰基-sn-甘油-3-磷酸胆碱、1,2-二花生四烯酰基-sn-甘油-3-磷酸胆碱、1,2-双二十二碳六烯酰基-sn-甘油-3-磷酸胆碱、1,2-二油酰基-sn-甘油-3-磷酸乙醇胺(DOPE)、1,2-二植烷酰基-sn-甘油-3-磷酸乙醇胺(ME 16 .0PE)、1 ,2-二硬脂酰基-sn-甘油-3-磷酸乙醇胺、1,2-二亚油酰基-sn-甘油-3-磷酸乙醇胺、1,2-二亚麻酰基-sn-甘油-3-磷酸乙醇胺、1,2-二花生四烯酰基-sn-甘油-3-磷酸乙醇胺、1,2-双二十二碳六烯酰基-sn-甘油-3-磷酸乙醇胺、1,2-二油酰基-sn-甘油-3-磷酸-rac-(1-甘油)钠盐(DOPG)、二棕榈酰基磷脂酰甘油(DPPG)、棕榈酰基油酰基磷脂酰乙醇胺(POPE)、二硬脂酰基-磷脂酰-乙醇胺(DSPE)、二棕榈酰基磷脂酰乙醇胺(DPPE)、二肉豆蔻酰基磷酸乙醇胺(DMPE)、1-硬脂酰基-2-油酰基-硬脂酰乙醇胺(SOPE)、1-硬脂酰基-2-油酰基-磷脂酰胆碱(SOPC)、鞘磷脂、磷脂酰胆碱、磷脂酰乙醇胺、磷脂酰丝氨酸、磷脂酰肌醇、磷脂酸、棕榈酰基油酰基磷脂酰胆碱、溶血磷脂酰胆碱和溶血磷脂酰乙醇胺(LPE)。
62.如权利要求47所述的组合物，其中所述中性脂质是DOPE和/或DSPC。
63.如权利要求47所述的组合物，其中所述结构性脂质选自以下中的一种或更多种：胆固醇、非甾醇、谷固醇、麦角固醇、菜油甾醇、豆甾醇、芸苔甾醇、番茄碱、熊果酸、α-生育酚、皮质类固醇。
64.如权利要求63所述的组合物，其中所述结构性脂质是胆固醇。
65.如权利要求47所述的组合物，其中所述聚合物共轭脂质选自以下中的一种或更多种：PEG修饰的磷脂酰乙醇胺、PEG修饰的磷脂酸、PEG修饰的神经酰胺、PEG修饰的二烷基胺、PEG修饰的二酰基甘油、PEG修饰的二烷基甘油。
66.如前述权利要求65所述的组合物，其中所述聚合物共轭脂质选自以下中的一种或更多种：二硬脂酰基磷脂酰乙醇胺聚乙二醇2000(DSPE-PEG2000)，二肉豆蔻酰甘油-3-甲氧基聚乙二醇2000(DMG-PEG2000)和甲氧基聚乙二醇双十四烷基乙酰胺(ALC-0159)。
67. 如权利要求44所述的组合物，其中所述RSV RNA的有效剂量为25 μg~200 μg；优选为50 μg~100 μg。
68.如权利要求44至67中任一项所述的组合物，其中所述疫苗为注射剂型的形式。
69.制备如权利要求44至68中任一项所述组合物的方法，包括：将所述RSV的RNA与所述可药用载剂混合。
70.权利要求1至41和44至68中任一项所述的组合物在制备用于在对象中诱导针对RSV的保护性免疫应答特别是体液免疫应答的疫苗中的用途。
71.权利要求1至41和44至68中任一项所述的组合物在制备预防RSV感染的疫苗中的用途。
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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102307591A (zh) * 2008-12-09 2012-01-04 诺瓦瓦克斯股份有限公司 修饰的rsv f蛋白及其使用方法
CN112292395A (zh) * 2018-04-17 2021-01-29 库瑞瓦格股份公司 用于疫苗接种的新型rsv rna分子和组合物
US20230338506A1 (en) * 2020-01-30 2023-10-26 Modernatx, Inc. Respiratory virus immunizing compositions
CN118206622A (zh) * 2024-03-18 2024-06-18 艾美探索者生命科学研发有限公司 RSV融合前F蛋白的突变体、核酸及mRNA疫苗

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102307591A (zh) * 2008-12-09 2012-01-04 诺瓦瓦克斯股份有限公司 修饰的rsv f蛋白及其使用方法
CN112292395A (zh) * 2018-04-17 2021-01-29 库瑞瓦格股份公司 用于疫苗接种的新型rsv rna分子和组合物
US20230338506A1 (en) * 2020-01-30 2023-10-26 Modernatx, Inc. Respiratory virus immunizing compositions
CN118206622A (zh) * 2024-03-18 2024-06-18 艾美探索者生命科学研发有限公司 RSV融合前F蛋白的突变体、核酸及mRNA疫苗

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