CN1183118A - 具有降低的吸附作用和增加的水解作用的热酶变异体 - Google Patents
具有降低的吸附作用和增加的水解作用的热酶变异体 Download PDFInfo
- Publication number
- CN1183118A CN1183118A CN96193608A CN96193608A CN1183118A CN 1183118 A CN1183118 A CN 1183118A CN 96193608 A CN96193608 A CN 96193608A CN 96193608 A CN96193608 A CN 96193608A CN 1183118 A CN1183118 A CN 1183118A
- Authority
- CN
- China
- Prior art keywords
- amino acid
- asn
- substitution occurs
- asp
- glu
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000006460 hydrolysis reaction Methods 0.000 title claims abstract description 19
- 230000007062 hydrolysis Effects 0.000 title claims abstract description 18
- 238000001179 sorption measurement Methods 0.000 title claims abstract description 10
- 108010031354 thermitase Proteins 0.000 title claims abstract description 4
- 230000003247 decreasing effect Effects 0.000 title 1
- 239000000203 mixture Substances 0.000 claims abstract description 167
- 238000004140 cleaning Methods 0.000 claims abstract description 97
- 239000000758 substrate Substances 0.000 claims abstract description 25
- 108091028043 Nucleic acid sequence Proteins 0.000 claims abstract description 7
- 238000006467 substitution reaction Methods 0.000 claims abstract 57
- 125000003275 alpha amino acid group Chemical class 0.000 claims abstract 52
- 108090000790 Enzymes Proteins 0.000 claims description 152
- 102000004190 Enzymes Human genes 0.000 claims description 150
- -1 brighteners Substances 0.000 claims description 51
- 239000004744 fabric Substances 0.000 claims description 41
- 238000005406 washing Methods 0.000 claims description 19
- 239000003599 detergent Substances 0.000 claims description 18
- 239000003795 chemical substances by application Substances 0.000 claims description 14
- 210000000214 mouth Anatomy 0.000 claims description 12
- 238000004851 dishwashing Methods 0.000 claims description 10
- 239000002904 solvent Substances 0.000 claims description 10
- 239000002131 composite material Substances 0.000 claims description 7
- 239000000975 dye Substances 0.000 claims description 5
- 239000006260 foam Substances 0.000 claims description 5
- 239000004094 surface-active agent Substances 0.000 claims description 5
- 239000004927 clay Substances 0.000 claims description 4
- 239000000872 buffer Substances 0.000 claims description 3
- 239000002689 soil Substances 0.000 claims description 3
- 239000003381 stabilizer Substances 0.000 claims description 3
- 239000002270 dispersing agent Substances 0.000 claims description 2
- 125000001424 substituent group Chemical group 0.000 claims 7
- 239000002671 adjuvant Substances 0.000 claims 1
- 239000002304 perfume Substances 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 abstract description 102
- 102220640248 Mitochondrial 2-oxoglutarate/malate carrier protein_S220E_mutation Human genes 0.000 description 300
- 102220471019 Dual specificity mitogen-activated protein kinase kinase 6_S207E_mutation Human genes 0.000 description 194
- 102220499760 Lysine-tRNA ligase_S207D_mutation Human genes 0.000 description 150
- 229940088598 enzyme Drugs 0.000 description 146
- 102220568475 Dual specificity mitogen-activated protein kinase kinase 1_S222D_mutation Human genes 0.000 description 133
- 102220615455 CCAAT/enhancer-binding protein delta_T217E_mutation Human genes 0.000 description 131
- 102220472856 Potassium voltage-gated channel subfamily KQT member 2_T217D_mutation Human genes 0.000 description 119
- 102220542207 Probable polypeptide N-acetylgalactosaminyltransferase 8_S192D_mutation Human genes 0.000 description 101
- 102220576698 Phosphatidylinositol 4-kinase beta_T217Q_mutation Human genes 0.000 description 98
- 102220218691 rs763269347 Human genes 0.000 description 94
- 102220517754 Heat shock factor protein 1_S216E_mutation Human genes 0.000 description 89
- 102220273086 rs1555597189 Human genes 0.000 description 88
- 102220473333 Connector enhancer of kinase suppressor of ras 1_S216D_mutation Human genes 0.000 description 86
- 102220480401 H/ACA ribonucleoprotein complex subunit DKC1_L221D_mutation Human genes 0.000 description 81
- 235000001014 amino acid Nutrition 0.000 description 80
- 102220478239 Alpha-endosulfine_S109E_mutation Human genes 0.000 description 79
- 102220193161 rs1057516090 Human genes 0.000 description 73
- 102220516406 UDP-N-acetylglucosamine-peptide N-acetylglucosaminyltransferase 110 kDa subunit_W208E_mutation Human genes 0.000 description 70
- 102220500888 H/ACA ribonucleoprotein complex subunit DKC1_G223D_mutation Human genes 0.000 description 69
- 102220563514 Thrombomodulin_S109D_mutation Human genes 0.000 description 67
- 102220499467 ADP-ribosylation factor-binding protein GGA3_T217P_mutation Human genes 0.000 description 66
- 102220467381 Acyl-coenzyme A thioesterase MBLAC2_A219E_mutation Human genes 0.000 description 64
- 102220470056 M-phase inducer phosphatase 3_S191D_mutation Human genes 0.000 description 64
- 102220590672 Adenylosuccinate synthetase isozyme 1_N106S_mutation Human genes 0.000 description 62
- 102220511748 Dipeptidyl peptidase 1_Y210D_mutation Human genes 0.000 description 62
- 102220612105 E3 ubiquitin-protein ligase Topors_T224P_mutation Human genes 0.000 description 60
- 102220560783 Neuronal migration protein doublecortin_G223E_mutation Human genes 0.000 description 60
- 102220555361 X-box-binding protein 1_T212N_mutation Human genes 0.000 description 60
- 102220066135 rs192628905 Human genes 0.000 description 60
- 102220640183 Mitochondrial 2-oxoglutarate/malate carrier protein_T215D_mutation Human genes 0.000 description 59
- 102200128188 rs121908803 Human genes 0.000 description 58
- 102220501834 MOB kinase activator 2_S107D_mutation Human genes 0.000 description 57
- 102220195452 rs777767978 Human genes 0.000 description 57
- 102220222674 rs910355512 Human genes 0.000 description 52
- 102220513951 Mediator of DNA damage checkpoint protein 1_Y210A_mutation Human genes 0.000 description 51
- 102200041219 rs118203943 Human genes 0.000 description 50
- 102220558516 Proteinase-activated receptor 2_Y210L_mutation Human genes 0.000 description 49
- 102220223293 rs1060502955 Human genes 0.000 description 49
- 102220229923 rs1064793247 Human genes 0.000 description 49
- 102200061605 rs63750569 Human genes 0.000 description 49
- 102220097941 rs876659089 Human genes 0.000 description 48
- 102220512555 Homeobox protein Nkx-2.1_W208L_mutation Human genes 0.000 description 47
- 102200043618 rs28939677 Human genes 0.000 description 47
- 102220567220 Ras association domain-containing protein 6_L221D_mutation Human genes 0.000 description 46
- 102220644416 Glycogenin-2_P214G_mutation Human genes 0.000 description 45
- 102220625749 Protein pelota homolog_L221M_mutation Human genes 0.000 description 45
- 102220077745 rs879255581 Human genes 0.000 description 45
- 102220578337 Dual specificity protein kinase CLK3_S141E_mutation Human genes 0.000 description 44
- 102220474246 Histone-lysine N-methyltransferase 2B_T215N_mutation Human genes 0.000 description 42
- 102220512556 Homeobox protein Nkx-2.1_W208S_mutation Human genes 0.000 description 42
- 102220636392 Protein PALS2_L221G_mutation Human genes 0.000 description 42
- 102220199458 rs1057523249 Human genes 0.000 description 41
- 102200002383 rs3792683 Human genes 0.000 description 41
- 102220628991 Succinate receptor 1_W208A_mutation Human genes 0.000 description 40
- 102220586121 Tubulin polymerization-promoting protein_S107E_mutation Human genes 0.000 description 40
- 102220574922 Cellular tumor antigen p53_G108D_mutation Human genes 0.000 description 39
- 102220640147 Mitochondrial 2-oxoglutarate/malate carrier protein_T224D_mutation Human genes 0.000 description 39
- 102200149449 rs1800362 Human genes 0.000 description 39
- 102220590671 Adenylosuccinate synthetase isozyme 1_N106Y_mutation Human genes 0.000 description 38
- 102220473410 Photoreceptor ankyrin repeat protein_V138G_mutation Human genes 0.000 description 38
- 102220484493 Tryptase alpha/beta-1_T215S_mutation Human genes 0.000 description 38
- 102220286954 rs149937815 Human genes 0.000 description 38
- 102220286485 rs1554074731 Human genes 0.000 description 38
- 102220627977 Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2_N106T_mutation Human genes 0.000 description 36
- 102220531760 Retinoid-inducible serine carboxypeptidase_Y210H_mutation Human genes 0.000 description 36
- 102220200923 rs1057520583 Human genes 0.000 description 35
- 102200060063 rs35151472 Human genes 0.000 description 35
- 102220337574 rs779258184 Human genes 0.000 description 35
- 102220350738 c.506C>A Human genes 0.000 description 34
- 102220080884 rs863223501 Human genes 0.000 description 34
- 102220510033 Importin-7_T111N_mutation Human genes 0.000 description 33
- 102220234051 rs1114167456 Human genes 0.000 description 33
- 102200017869 rs387906614 Human genes 0.000 description 33
- 102220036886 rs587780103 Human genes 0.000 description 32
- 102220488976 Alkaline phosphatase, tissue-nonspecific isozyme_N170D_mutation Human genes 0.000 description 31
- 102220618144 Gamma-interferon-inducible protein 16_Y218A_mutation Human genes 0.000 description 31
- 102220640169 Mitochondrial 2-oxoglutarate/malate carrier protein_T215E_mutation Human genes 0.000 description 31
- 102220479621 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN_T167D_mutation Human genes 0.000 description 31
- 102200094698 c.661C>G Human genes 0.000 description 31
- 102220223990 rs142886157 Human genes 0.000 description 31
- 102220267028 rs1554945246 Human genes 0.000 description 31
- 102220044983 rs587781733 Human genes 0.000 description 31
- 230000008859 change Effects 0.000 description 30
- 102200141491 rs104893793 Human genes 0.000 description 30
- 102220264777 rs1182554152 Human genes 0.000 description 30
- 102200036652 rs121434424 Human genes 0.000 description 30
- 102200077462 rs747821285 Human genes 0.000 description 30
- 102220278920 rs777840257 Human genes 0.000 description 30
- 102220488972 Alkaline phosphatase, tissue-nonspecific isozyme_G162S_mutation Human genes 0.000 description 28
- 102220466593 Chitobiosyldiphosphodolichol beta-mannosyltransferase_I209S_mutation Human genes 0.000 description 28
- 102220515246 Serum response factor-binding protein 1_T195N_mutation Human genes 0.000 description 28
- 102220498076 Transmembrane 4 L6 family member 20_N163Q_mutation Human genes 0.000 description 28
- 102220248877 rs1556403086 Human genes 0.000 description 28
- 102200117906 rs33910475 Human genes 0.000 description 28
- 102220097942 rs876660846 Human genes 0.000 description 28
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 27
- 102220606740 Hemoglobin subunit beta_N140S_mutation Human genes 0.000 description 27
- 102220481661 Matrilin-3_Y218N_mutation Human genes 0.000 description 27
- 102200053639 rs879255237 Human genes 0.000 description 27
- 102220603318 Homeobox protein SIX3_V138D_mutation Human genes 0.000 description 26
- 102220547866 Nucleobindin-1_N140Q_mutation Human genes 0.000 description 25
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 25
- 102220203083 rs1057524847 Human genes 0.000 description 25
- 102220311892 rs1555621662 Human genes 0.000 description 25
- 239000007788 liquid Substances 0.000 description 24
- 102220282423 rs1160353919 Human genes 0.000 description 24
- 102220225158 rs144769597 Human genes 0.000 description 24
- 102220290781 rs1555853906 Human genes 0.000 description 24
- 102220126947 rs548449293 Human genes 0.000 description 24
- 102220036333 rs587779776 Human genes 0.000 description 24
- 102220274760 rs764621521 Human genes 0.000 description 24
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 24
- 102220574905 Endoglin_L221Q_mutation Human genes 0.000 description 22
- 102220578813 Maternal embryonic leucine zipper kinase_T167E_mutation Human genes 0.000 description 22
- 102220479538 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN_T167P_mutation Human genes 0.000 description 22
- 239000002245 particle Substances 0.000 description 22
- 102220242938 rs770592607 Human genes 0.000 description 22
- 102220486870 Gap junction beta-1 protein_F193L_mutation Human genes 0.000 description 21
- 102220571405 Mitofusin-2_T111E_mutation Human genes 0.000 description 21
- 102200068639 rs281865234 Human genes 0.000 description 21
- 102220466718 Olfactory receptor 8U1_T137S_mutation Human genes 0.000 description 20
- 102220469046 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN_G165E_mutation Human genes 0.000 description 20
- 102220220756 rs1060500100 Human genes 0.000 description 20
- 102220328197 rs1233795152 Human genes 0.000 description 20
- 102220315758 rs1553606126 Human genes 0.000 description 20
- 102200047013 rs61752144 Human genes 0.000 description 20
- 102220289331 rs748026786 Human genes 0.000 description 20
- 239000011734 sodium Substances 0.000 description 20
- 229910052708 sodium Inorganic materials 0.000 description 20
- 102220615190 Extracellular calcium-sensing receptor_Y218S_mutation Human genes 0.000 description 19
- 102220481793 Neutral amino acid transporter A_A164G_mutation Human genes 0.000 description 19
- 102200007912 rs128626236 Human genes 0.000 description 19
- 102200016535 rs2335052 Human genes 0.000 description 19
- 102200044067 rs28462216 Human genes 0.000 description 19
- 102220205168 rs374601719 Human genes 0.000 description 19
- 102000035195 Peptidases Human genes 0.000 description 18
- 108091005804 Peptidases Proteins 0.000 description 18
- 102220468064 Podocan-like protein 1_P169G_mutation Human genes 0.000 description 18
- 102220249183 rs1320839573 Human genes 0.000 description 18
- 102220104590 rs750655995 Human genes 0.000 description 18
- 102220633572 39S ribosomal protein S30, mitochondrial_A168Q_mutation Human genes 0.000 description 17
- 102220505020 Chymotrypsin-C_I209M_mutation Human genes 0.000 description 17
- 102220605687 DNA-(apurinic or apyrimidinic site) endonuclease_Y171H_mutation Human genes 0.000 description 17
- 102220324899 rs1555407906 Human genes 0.000 description 17
- 102220076320 rs200926225 Human genes 0.000 description 17
- 102200107847 rs587782461 Human genes 0.000 description 17
- 102220157187 rs770738729 Human genes 0.000 description 17
- 102220126331 rs778956037 Human genes 0.000 description 17
- 102220602134 NACHT, LRR and PYD domains-containing protein 10_I209L_mutation Human genes 0.000 description 16
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 16
- 102220573168 Tyrosine-protein kinase Fer_I209A_mutation Human genes 0.000 description 16
- 102200002323 rs104893873 Human genes 0.000 description 16
- 102220075241 rs141919651 Human genes 0.000 description 16
- 102220240495 rs755619001 Human genes 0.000 description 16
- 102220059046 rs774162322 Human genes 0.000 description 16
- 102220059857 rs786201252 Human genes 0.000 description 16
- 102200004203 rs199472685 Human genes 0.000 description 15
- 102220093847 rs745808534 Human genes 0.000 description 15
- 102220519803 Prolyl 4-hydroxylase subunit alpha-1_Y213A_mutation Human genes 0.000 description 14
- 102220581088 Protein fem-1 homolog B_F193A_mutation Human genes 0.000 description 14
- 102220350009 c.332C>G Human genes 0.000 description 14
- 238000002360 preparation method Methods 0.000 description 14
- 102220236141 rs1131691437 Human genes 0.000 description 14
- 102220261340 rs1554129925 Human genes 0.000 description 14
- 102220130035 rs369957092 Human genes 0.000 description 14
- 102200062430 rs397514559 Human genes 0.000 description 14
- 235000013599 spices Nutrition 0.000 description 14
- 102220560158 Fibulin-7_T137G_mutation Human genes 0.000 description 13
- 102220575243 HLA class I histocompatibility antigen, B alpha chain_T167S_mutation Human genes 0.000 description 13
- 102220470448 Adenosine 5'-monophosphoramidase HINT2_V115D_mutation Human genes 0.000 description 12
- 102220488940 Alkaline phosphatase, tissue-nonspecific isozyme_A114G_mutation Human genes 0.000 description 12
- 102220539680 Chromosome alignment-maintaining phosphoprotein 1_L134E_mutation Human genes 0.000 description 12
- 102220590506 Maltase-glucoamylase_T137P_mutation Human genes 0.000 description 12
- 102220600433 Serum amyloid A-1 protein_W112A_mutation Human genes 0.000 description 12
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 12
- 239000013543 active substance Substances 0.000 description 12
- 230000005684 electric field Effects 0.000 description 12
- 102220282889 rs1555617812 Human genes 0.000 description 12
- 102220234014 rs753614067 Human genes 0.000 description 12
- 102220239063 rs948435492 Human genes 0.000 description 12
- 229910021536 Zeolite Inorganic materials 0.000 description 11
- 238000010521 absorption reaction Methods 0.000 description 11
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 description 11
- 102220126276 rs372832497 Human genes 0.000 description 11
- 102220198541 rs74658848 Human genes 0.000 description 11
- 102220101144 rs750655995 Human genes 0.000 description 11
- 102220280417 rs759535768 Human genes 0.000 description 11
- 102200146993 rs768091663 Human genes 0.000 description 11
- 239000010457 zeolite Substances 0.000 description 11
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 10
- 102220550497 Fibroblast growth factor 13_Y171W_mutation Human genes 0.000 description 10
- 102220542865 Presenilins-associated rhomboid-like protein, mitochondrial_S70D_mutation Human genes 0.000 description 10
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 10
- 108090000623 proteins and genes Proteins 0.000 description 10
- 102200094524 rs147589613 Human genes 0.000 description 10
- 239000000243 solution Substances 0.000 description 10
- 102220616475 Diamine acetyltransferase 1_L134A_mutation Human genes 0.000 description 9
- 102220609134 Interleukin-1 alpha_A114S_mutation Human genes 0.000 description 9
- 239000004020 conductor Substances 0.000 description 9
- 238000000034 method Methods 0.000 description 9
- 235000018102 proteins Nutrition 0.000 description 9
- 102000004169 proteins and genes Human genes 0.000 description 9
- 102220197437 rs1057519461 Human genes 0.000 description 9
- 102200127036 rs11553094 Human genes 0.000 description 9
- 102200110904 rs121917881 Human genes 0.000 description 9
- 102220092655 rs876657790 Human genes 0.000 description 9
- 108020004414 DNA Proteins 0.000 description 8
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 8
- 102220473114 HLA class II histocompatibility antigen, DP alpha 1 chain_L104A_mutation Human genes 0.000 description 8
- 102220514139 Mediator of DNA damage checkpoint protein 1_G72N_mutation Human genes 0.000 description 8
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 8
- 102220421980 c.512A>G Human genes 0.000 description 8
- 239000003153 chemical reaction reagent Substances 0.000 description 8
- 230000035772 mutation Effects 0.000 description 8
- 102220196096 rs1057518583 Human genes 0.000 description 8
- 102200164338 rs63749939 Human genes 0.000 description 8
- 235000017550 sodium carbonate Nutrition 0.000 description 8
- 229910000029 sodium carbonate Inorganic materials 0.000 description 8
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 7
- 102220546452 Insulin-like growth factor-binding protein complex acid labile subunit_L134Q_mutation Human genes 0.000 description 7
- 102220600430 Serum amyloid A-1 protein_W112F_mutation Human genes 0.000 description 7
- 239000000843 powder Substances 0.000 description 7
- 102200164039 rs121908581 Human genes 0.000 description 7
- 102200074796 rs1554499091 Human genes 0.000 description 7
- 238000012360 testing method Methods 0.000 description 7
- 102220486867 Gap junction beta-1 protein_F193C_mutation Human genes 0.000 description 6
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 6
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 6
- 102220477261 Meiosis 1 arrest protein_T195P_mutation Human genes 0.000 description 6
- BPQQTUXANYXVAA-UHFFFAOYSA-N Orthosilicate Chemical compound [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 description 6
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 6
- 102220631305 Spermatogenesis-associated protein 21_Y171V_mutation Human genes 0.000 description 6
- 102220630035 Stress-responsive DNAJB4-interacting membrane protein 1_N68Q_mutation Human genes 0.000 description 6
- 239000004567 concrete Substances 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 210000003128 head Anatomy 0.000 description 6
- 230000003301 hydrolyzing effect Effects 0.000 description 6
- 230000001939 inductive effect Effects 0.000 description 6
- 102220013352 rs397516579 Human genes 0.000 description 6
- 102200047469 rs864309655 Human genes 0.000 description 6
- 102220097719 rs876658195 Human genes 0.000 description 6
- 238000003860 storage Methods 0.000 description 6
- 229910021653 sulphate ion Inorganic materials 0.000 description 6
- FRPJTGXMTIIFIT-UHFFFAOYSA-N tetraacetylethylenediamine Chemical compound CC(=O)C(N)(C(C)=O)C(N)(C(C)=O)C(C)=O FRPJTGXMTIIFIT-UHFFFAOYSA-N 0.000 description 6
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 5
- 108010059892 Cellulase Proteins 0.000 description 5
- 102220599936 Disks large-associated protein 5_G69E_mutation Human genes 0.000 description 5
- 102000004882 Lipase Human genes 0.000 description 5
- 108090001060 Lipase Proteins 0.000 description 5
- 239000004367 Lipase Substances 0.000 description 5
- 108090000787 Subtilisin Proteins 0.000 description 5
- 239000002253 acid Substances 0.000 description 5
- 239000012752 auxiliary agent Substances 0.000 description 5
- 229940077388 benzenesulfonate Drugs 0.000 description 5
- 239000001768 carboxy methyl cellulose Substances 0.000 description 5
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 5
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 5
- 229940106157 cellulase Drugs 0.000 description 5
- 210000000031 electric organ Anatomy 0.000 description 5
- 238000007046 ethoxylation reaction Methods 0.000 description 5
- 230000006698 induction Effects 0.000 description 5
- 235000019421 lipase Nutrition 0.000 description 5
- 239000013612 plasmid Substances 0.000 description 5
- 229920000642 polymer Polymers 0.000 description 5
- 102220258285 rs63751397 Human genes 0.000 description 5
- 102220281791 rs904361724 Human genes 0.000 description 5
- 239000001509 sodium citrate Substances 0.000 description 5
- 239000001488 sodium phosphate Substances 0.000 description 5
- 229910000162 sodium phosphate Inorganic materials 0.000 description 5
- 229910052938 sodium sulfate Inorganic materials 0.000 description 5
- 235000011152 sodium sulphate Nutrition 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 239000013638 trimer Substances 0.000 description 5
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical class [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 5
- 235000019263 trisodium citrate Nutrition 0.000 description 5
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 5
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 4
- 239000007983 Tris buffer Substances 0.000 description 4
- 150000001412 amines Chemical class 0.000 description 4
- 238000005282 brightening Methods 0.000 description 4
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 4
- 235000011187 glycerol Nutrition 0.000 description 4
- 230000006872 improvement Effects 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 238000002703 mutagenesis Methods 0.000 description 4
- 231100000350 mutagenesis Toxicity 0.000 description 4
- 230000007935 neutral effect Effects 0.000 description 4
- 125000003367 polycyclic group Chemical group 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 230000009467 reduction Effects 0.000 description 4
- 102220119544 rs200102936 Human genes 0.000 description 4
- 102200142166 rs35258119 Human genes 0.000 description 4
- 102200012398 rs7732671 Human genes 0.000 description 4
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- 239000003826 tablet Substances 0.000 description 4
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 4
- 102220609107 AP-4 complex accessory subunit Tepsin_T73S_mutation Human genes 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 3
- 102220617030 C-type lectin domain family 10 member A_A203G_mutation Human genes 0.000 description 3
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 3
- 244000060011 Cocos nucifera Species 0.000 description 3
- 235000013162 Cocos nucifera Nutrition 0.000 description 3
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 108091034117 Oligonucleotide Proteins 0.000 description 3
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 3
- 239000004115 Sodium Silicate Substances 0.000 description 3
- 229920006243 acrylic copolymer Polymers 0.000 description 3
- 125000000217 alkyl group Chemical group 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 3
- 239000002738 chelating agent Substances 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 239000013530 defoamer Substances 0.000 description 3
- 230000005672 electromagnetic field Effects 0.000 description 3
- 150000002148 esters Chemical class 0.000 description 3
- 238000000855 fermentation Methods 0.000 description 3
- 230000004151 fermentation Effects 0.000 description 3
- 239000000945 filler Substances 0.000 description 3
- 239000011521 glass Substances 0.000 description 3
- 150000002500 ions Chemical class 0.000 description 3
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 3
- 235000019341 magnesium sulphate Nutrition 0.000 description 3
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 3
- 239000011976 maleic acid Substances 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 229910052751 metal Inorganic materials 0.000 description 3
- 239000002184 metal Substances 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 239000002324 mouth wash Substances 0.000 description 3
- 229940051866 mouthwash Drugs 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 108090000765 processed proteins & peptides Proteins 0.000 description 3
- 102220024910 rs199472868 Human genes 0.000 description 3
- 102220057648 rs730881915 Human genes 0.000 description 3
- 102220213362 rs754978707 Human genes 0.000 description 3
- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 description 3
- 235000019795 sodium metasilicate Nutrition 0.000 description 3
- 229940048086 sodium pyrophosphate Drugs 0.000 description 3
- NTHWMYGWWRZVTN-UHFFFAOYSA-N sodium silicate Chemical compound [Na+].[Na+].[O-][Si]([O-])=O NTHWMYGWWRZVTN-UHFFFAOYSA-N 0.000 description 3
- 229910052911 sodium silicate Inorganic materials 0.000 description 3
- 239000000600 sorbitol Substances 0.000 description 3
- 235000019818 tetrasodium diphosphate Nutrition 0.000 description 3
- 239000001577 tetrasodium phosphonato phosphate Substances 0.000 description 3
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 3
- 239000003981 vehicle Substances 0.000 description 3
- BPIUIOXAFBGMNB-UHFFFAOYSA-N 1-hexoxyhexane Chemical compound CCCCCCOCCCCCC BPIUIOXAFBGMNB-UHFFFAOYSA-N 0.000 description 2
- 239000004382 Amylase Substances 0.000 description 2
- 102000013142 Amylases Human genes 0.000 description 2
- 108010065511 Amylases Proteins 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 244000063299 Bacillus subtilis Species 0.000 description 2
- 235000014469 Bacillus subtilis Nutrition 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 2
- 108020004705 Codon Proteins 0.000 description 2
- 238000001712 DNA sequencing Methods 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- 239000007987 MES buffer Substances 0.000 description 2
- QPCDCPDFJACHGM-UHFFFAOYSA-N N,N-bis{2-[bis(carboxymethyl)amino]ethyl}glycine Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(=O)O)CCN(CC(O)=O)CC(O)=O QPCDCPDFJACHGM-UHFFFAOYSA-N 0.000 description 2
- 229910019142 PO4 Inorganic materials 0.000 description 2
- 239000004365 Protease Substances 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 229920002125 Sokalan® Polymers 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- 108010056079 Subtilisins Proteins 0.000 description 2
- 102000005158 Subtilisins Human genes 0.000 description 2
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
- 235000019418 amylase Nutrition 0.000 description 2
- 239000002585 base Substances 0.000 description 2
- 235000015278 beef Nutrition 0.000 description 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
- 239000001110 calcium chloride Substances 0.000 description 2
- 229910001628 calcium chloride Inorganic materials 0.000 description 2
- 238000006555 catalytic reaction Methods 0.000 description 2
- 229940112822 chewing gum Drugs 0.000 description 2
- 235000015218 chewing gum Nutrition 0.000 description 2
- 235000014113 dietary fatty acids Nutrition 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000010828 elution Methods 0.000 description 2
- 150000002169 ethanolamines Chemical class 0.000 description 2
- IFQUWYZCAGRUJN-UHFFFAOYSA-N ethylenediaminediacetic acid Chemical compound OC(=O)CNCCNCC(O)=O IFQUWYZCAGRUJN-UHFFFAOYSA-N 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000000194 fatty acid Substances 0.000 description 2
- 229930195729 fatty acid Natural products 0.000 description 2
- 235000003599 food sweetener Nutrition 0.000 description 2
- 239000012634 fragment Substances 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 2
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 230000000968 intestinal effect Effects 0.000 description 2
- 238000004900 laundering Methods 0.000 description 2
- 235000012204 lemonade/lime carbonate Nutrition 0.000 description 2
- 239000007937 lozenge Substances 0.000 description 2
- 229910001629 magnesium chloride Inorganic materials 0.000 description 2
- 235000010355 mannitol Nutrition 0.000 description 2
- 235000013372 meat Nutrition 0.000 description 2
- 230000001590 oxidative effect Effects 0.000 description 2
- 239000006072 paste Substances 0.000 description 2
- 229960003330 pentetic acid Drugs 0.000 description 2
- 229940044652 phenolsulfonate Drugs 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 2
- 239000010452 phosphate Substances 0.000 description 2
- 239000000049 pigment Substances 0.000 description 2
- 229920000058 polyacrylate Polymers 0.000 description 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 2
- USHAGKDGDHPEEY-UHFFFAOYSA-L potassium persulfate Chemical compound [K+].[K+].[O-]S(=O)(=O)OOS([O-])(=O)=O USHAGKDGDHPEEY-UHFFFAOYSA-L 0.000 description 2
- 235000019394 potassium persulphate Nutrition 0.000 description 2
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 2
- 238000000197 pyrolysis Methods 0.000 description 2
- 102220011019 rs397507513 Human genes 0.000 description 2
- 102220083493 rs863224605 Human genes 0.000 description 2
- 238000005070 sampling Methods 0.000 description 2
- 150000003333 secondary alcohols Chemical class 0.000 description 2
- 239000000377 silicon dioxide Substances 0.000 description 2
- 229910052814 silicon oxide Inorganic materials 0.000 description 2
- 238000002741 site-directed mutagenesis Methods 0.000 description 2
- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 2
- 239000011775 sodium fluoride Substances 0.000 description 2
- 235000013024 sodium fluoride Nutrition 0.000 description 2
- MWNQXXOSWHCCOZ-UHFFFAOYSA-L sodium;oxido carbonate Chemical compound [Na+].[O-]OC([O-])=O MWNQXXOSWHCCOZ-UHFFFAOYSA-L 0.000 description 2
- 235000014347 soups Nutrition 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 2
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 2
- 239000003765 sweetening agent Substances 0.000 description 2
- 239000000454 talc Substances 0.000 description 2
- 235000012222 talc Nutrition 0.000 description 2
- 229910052623 talc Inorganic materials 0.000 description 2
- 239000003760 tallow Substances 0.000 description 2
- 239000004753 textile Substances 0.000 description 2
- 229940034610 toothpaste Drugs 0.000 description 2
- 239000000606 toothpaste Substances 0.000 description 2
- 230000002087 whitening effect Effects 0.000 description 2
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 description 1
- VKZRWSNIWNFCIQ-WDSKDSINSA-N (2s)-2-[2-[[(1s)-1,2-dicarboxyethyl]amino]ethylamino]butanedioic acid Chemical compound OC(=O)C[C@@H](C(O)=O)NCCN[C@H](C(O)=O)CC(O)=O VKZRWSNIWNFCIQ-WDSKDSINSA-N 0.000 description 1
- OSSNTDFYBPYIEC-UHFFFAOYSA-N 1-ethenylimidazole Chemical compound C=CN1C=CN=C1 OSSNTDFYBPYIEC-UHFFFAOYSA-N 0.000 description 1
- MPJQXAIKMSKXBI-UHFFFAOYSA-N 2,7,9,14-tetraoxa-1,8-diazabicyclo[6.6.2]hexadecane-3,6,10,13-tetrone Chemical compound C1CN2OC(=O)CCC(=O)ON1OC(=O)CCC(=O)O2 MPJQXAIKMSKXBI-UHFFFAOYSA-N 0.000 description 1
- QCYOIFVBYZNUNW-UHFFFAOYSA-N 2-(dimethylazaniumyl)propanoate Chemical compound CN(C)C(C)C(O)=O QCYOIFVBYZNUNW-UHFFFAOYSA-N 0.000 description 1
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 1
- GOFRCQAMWWXIND-UHFFFAOYSA-N 2-[2-(2-phenylphenyl)ethenyl]benzenesulfonic acid;sodium Chemical compound [Na].[Na].OS(=O)(=O)C1=CC=CC=C1C=CC1=CC=CC=C1C1=CC=CC=C1 GOFRCQAMWWXIND-UHFFFAOYSA-N 0.000 description 1
- UXFQFBNBSPQBJW-UHFFFAOYSA-N 2-amino-2-methylpropane-1,3-diol Chemical compound OCC(N)(C)CO UXFQFBNBSPQBJW-UHFFFAOYSA-N 0.000 description 1
- JCAYXDKNUSEQRT-UHFFFAOYSA-N 2-aminoethoxyboronic acid Chemical compound NCCOB(O)O JCAYXDKNUSEQRT-UHFFFAOYSA-N 0.000 description 1
- POAOYUHQDCAZBD-UHFFFAOYSA-N 2-butoxyethanol Chemical compound CCCCOCCO POAOYUHQDCAZBD-UHFFFAOYSA-N 0.000 description 1
- UPGSWASWQBLSKZ-UHFFFAOYSA-N 2-hexoxyethanol Chemical compound CCCCCCOCCO UPGSWASWQBLSKZ-UHFFFAOYSA-N 0.000 description 1
- TYMLOMAKGOJONV-UHFFFAOYSA-N 4-nitroaniline Chemical compound NC1=CC=C([N+]([O-])=O)C=C1 TYMLOMAKGOJONV-UHFFFAOYSA-N 0.000 description 1
- GJCOSYZMQJWQCA-UHFFFAOYSA-N 9H-xanthene Chemical compound C1=CC=C2CC3=CC=CC=C3OC2=C1 GJCOSYZMQJWQCA-UHFFFAOYSA-N 0.000 description 1
- 206010002198 Anaphylactic reaction Diseases 0.000 description 1
- 108090000145 Bacillolysin Proteins 0.000 description 1
- 241000193830 Bacillus <bacterium> Species 0.000 description 1
- 239000005711 Benzoic acid Substances 0.000 description 1
- 102220499774 Carbonic anhydrase 2_N67Q_mutation Human genes 0.000 description 1
- YASYEJJMZJALEJ-UHFFFAOYSA-N Citric acid monohydrate Chemical compound O.OC(=O)CC(O)(C(O)=O)CC(O)=O YASYEJJMZJALEJ-UHFFFAOYSA-N 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 102220531719 Fms-related tyrosine kinase 3 ligand_G68P_mutation Human genes 0.000 description 1
- BDAGIHXWWSANSR-UHFFFAOYSA-M Formate Chemical compound [O-]C=O BDAGIHXWWSANSR-UHFFFAOYSA-M 0.000 description 1
- 241000755093 Gaidropsarus vulgaris Species 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 102220633264 Hexokinase-4_G68D_mutation Human genes 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 102220602132 NACHT, LRR and PYD domains-containing protein 10_I209E_mutation Human genes 0.000 description 1
- BCXBKOQDEOJNRH-UHFFFAOYSA-N NOP(O)=O Chemical class NOP(O)=O BCXBKOQDEOJNRH-UHFFFAOYSA-N 0.000 description 1
- 240000002853 Nelumbo nucifera Species 0.000 description 1
- 235000006508 Nelumbo nucifera Nutrition 0.000 description 1
- 235000006510 Nelumbo pentapetala Nutrition 0.000 description 1
- 108091005507 Neutral proteases Proteins 0.000 description 1
- 239000006057 Non-nutritive feed additive Substances 0.000 description 1
- IFVNATVJZVXOFC-UHFFFAOYSA-N OC(CCC(O)=O)=O.OC(CCC(O)=O)=O.O.O Chemical compound OC(CCC(O)=O)=O.OC(CCC(O)=O)=O.O.O IFVNATVJZVXOFC-UHFFFAOYSA-N 0.000 description 1
- RCEAADKTGXTDOA-UHFFFAOYSA-N OS(O)(=O)=O.CCCCCCCCCCCC[Na] Chemical compound OS(O)(=O)=O.CCCCCCCCCCCC[Na] RCEAADKTGXTDOA-UHFFFAOYSA-N 0.000 description 1
- 239000005642 Oleic acid Substances 0.000 description 1
- 238000012408 PCR amplification Methods 0.000 description 1
- 102000003992 Peroxidases Human genes 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 102220630442 Presenilin-1_G206D_mutation Human genes 0.000 description 1
- 108010009736 Protein Hydrolysates Proteins 0.000 description 1
- 102220495658 Putative uncharacterized protein FLJ43944_G68Q_mutation Human genes 0.000 description 1
- 102220573177 Ras-related protein Ral-A_S194D_mutation Human genes 0.000 description 1
- 240000000528 Ricinus communis Species 0.000 description 1
- 235000004443 Ricinus communis Nutrition 0.000 description 1
- 102220509109 Sentrin-specific protease 1_G67V_mutation Human genes 0.000 description 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 1
- 102000012479 Serine Proteases Human genes 0.000 description 1
- 108010022999 Serine Proteases Proteins 0.000 description 1
- BLRPTPMANUNPDV-UHFFFAOYSA-N Silane Chemical compound [SiH4] BLRPTPMANUNPDV-UHFFFAOYSA-N 0.000 description 1
- ULUAUXLGCMPNKK-UHFFFAOYSA-N Sulfobutanedioic acid Chemical compound OC(=O)CC(C(O)=O)S(O)(=O)=O ULUAUXLGCMPNKK-UHFFFAOYSA-N 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- 101710162629 Trypsin inhibitor Proteins 0.000 description 1
- 229940122618 Trypsin inhibitor Drugs 0.000 description 1
- 241001672648 Vieira Species 0.000 description 1
- 102220540204 WD repeat and coiled-coil-containing protein_T73E_mutation Human genes 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- DPDMMXDBJGCCQC-UHFFFAOYSA-N [Na].[Cl] Chemical compound [Na].[Cl] DPDMMXDBJGCCQC-UHFFFAOYSA-N 0.000 description 1
- IRFDFBONAWVESQ-UHFFFAOYSA-M [OH-].[Na+].C=1(C(=CC=CC1)S(=O)(=O)O)C(C)C Chemical compound [OH-].[Na+].C=1(C(=CC=CC1)S(=O)(=O)O)C(C)C IRFDFBONAWVESQ-UHFFFAOYSA-M 0.000 description 1
- 239000003082 abrasive agent Substances 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000012190 activator Substances 0.000 description 1
- 125000002252 acyl group Chemical group 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 238000005377 adsorption chromatography Methods 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 125000005037 alkyl phenyl group Chemical group 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 230000036783 anaphylactic response Effects 0.000 description 1
- 208000003455 anaphylaxis Diseases 0.000 description 1
- 239000003945 anionic surfactant Substances 0.000 description 1
- 150000001450 anions Chemical class 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- SRSXLGNVWSONIS-UHFFFAOYSA-M benzenesulfonate Chemical compound [O-]S(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-M 0.000 description 1
- 235000010233 benzoic acid Nutrition 0.000 description 1
- 238000004061 bleaching Methods 0.000 description 1
- 239000007844 bleaching agent Substances 0.000 description 1
- 229910021538 borax Inorganic materials 0.000 description 1
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 1
- 239000004327 boric acid Substances 0.000 description 1
- 239000006172 buffering agent Substances 0.000 description 1
- 102220370914 c.200A>G Human genes 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 229940041514 candida albicans extract Drugs 0.000 description 1
- 239000003990 capacitor Substances 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 239000000679 carrageenan Substances 0.000 description 1
- 235000010418 carrageenan Nutrition 0.000 description 1
- 229920001525 carrageenan Polymers 0.000 description 1
- 229940113118 carrageenan Drugs 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 239000005018 casein Substances 0.000 description 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
- 235000021240 caseins Nutrition 0.000 description 1
- 230000003197 catalytic effect Effects 0.000 description 1
- 238000005277 cation exchange chromatography Methods 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- WIIZWVCIJKGZOK-RKDXNWHRSA-N chloramphenicol Chemical compound ClC(Cl)C(=O)N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 WIIZWVCIJKGZOK-RKDXNWHRSA-N 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 235000015165 citric acid Nutrition 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid group Chemical class C(CC(O)(C(=O)O)CC(=O)O)(=O)O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 1
- 229960002303 citric acid monohydrate Drugs 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 235000008504 concentrate Nutrition 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 239000004064 cosurfactant Substances 0.000 description 1
- 239000007822 coupling agent Substances 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- NSFKBZXCXCJZDQ-UHFFFAOYSA-N cumene;sodium Chemical compound [Na].CC(C)C1=CC=CC=C1 NSFKBZXCXCJZDQ-UHFFFAOYSA-N 0.000 description 1
- 230000001186 cumulative effect Effects 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000012217 deletion Methods 0.000 description 1
- 230000037430 deletion Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- GSPKZYJPUDYKPI-UHFFFAOYSA-N diethoxy sulfate Chemical compound CCOOS(=O)(=O)OOCC GSPKZYJPUDYKPI-UHFFFAOYSA-N 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000007938 effervescent tablet Substances 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 230000005674 electromagnetic induction Effects 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- CCIVGXIOQKPBKL-UHFFFAOYSA-N ethanesulfonic acid Chemical compound CCS(O)(=O)=O CCIVGXIOQKPBKL-UHFFFAOYSA-N 0.000 description 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 1
- 229940071087 ethylenediamine disuccinate Drugs 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 239000002979 fabric softener Substances 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000005187 foaming Methods 0.000 description 1
- 229930182478 glucoside Natural products 0.000 description 1
- 150000008131 glucosides Chemical class 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 101150008103 hal gene Proteins 0.000 description 1
- IIRDTKBZINWQAW-UHFFFAOYSA-N hexaethylene glycol Chemical compound OCCOCCOCCOCCOCCOCCO IIRDTKBZINWQAW-UHFFFAOYSA-N 0.000 description 1
- 229940051250 hexylene glycol Drugs 0.000 description 1
- 239000000413 hydrolysate Substances 0.000 description 1
- DCPMPXBYPZGNDC-UHFFFAOYSA-N hydron;methanediimine;chloride Chemical compound Cl.N=C=N DCPMPXBYPZGNDC-UHFFFAOYSA-N 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 210000001503 joint Anatomy 0.000 description 1
- 238000012417 linear regression Methods 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000012669 liquid formulation Substances 0.000 description 1
- 159000000003 magnesium salts Chemical class 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- IZXGZAJMDLJLMF-UHFFFAOYSA-N methylaminomethanol Chemical compound CNCO IZXGZAJMDLJLMF-UHFFFAOYSA-N 0.000 description 1
- 238000003032 molecular docking Methods 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- CQDGTJPVBWZJAZ-UHFFFAOYSA-N monoethyl carbonate Chemical compound CCOC(O)=O CQDGTJPVBWZJAZ-UHFFFAOYSA-N 0.000 description 1
- 150000004682 monohydrates Chemical class 0.000 description 1
- LNOPIUAQISRISI-UHFFFAOYSA-N n'-hydroxy-2-propan-2-ylsulfonylethanimidamide Chemical compound CC(C)S(=O)(=O)CC(N)=NO LNOPIUAQISRISI-UHFFFAOYSA-N 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 229940041678 oral spray Drugs 0.000 description 1
- 239000000668 oral spray Substances 0.000 description 1
- 230000010355 oscillation Effects 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 229940049547 paraxin Drugs 0.000 description 1
- RGSFGYAAUTVSQA-UHFFFAOYSA-N pentamethylene Natural products C1CCCC1 RGSFGYAAUTVSQA-UHFFFAOYSA-N 0.000 description 1
- 108040007629 peroxidase activity proteins Proteins 0.000 description 1
- 150000003009 phosphonic acids Chemical class 0.000 description 1
- 150000003016 phosphoric acids Chemical class 0.000 description 1
- 229910052615 phyllosilicate Inorganic materials 0.000 description 1
- 108010064470 polyaspartate Proteins 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical class CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000003531 protein hydrolysate Substances 0.000 description 1
- 238000001742 protein purification Methods 0.000 description 1
- 230000002797 proteolythic effect Effects 0.000 description 1
- 235000019633 pungent taste Nutrition 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 108091008146 restriction endonucleases Proteins 0.000 description 1
- 102200060543 rs1060505037 Human genes 0.000 description 1
- 102220323495 rs1170323988 Human genes 0.000 description 1
- 102200085502 rs121917883 Human genes 0.000 description 1
- 102200090690 rs137852487 Human genes 0.000 description 1
- 102220126492 rs139093654 Human genes 0.000 description 1
- 102220281547 rs1555514410 Human genes 0.000 description 1
- 102200118202 rs33947415 Human genes 0.000 description 1
- 102200118200 rs34718174 Human genes 0.000 description 1
- 102220005500 rs34823698 Human genes 0.000 description 1
- 102220049864 rs587783571 Human genes 0.000 description 1
- 102220222692 rs775045445 Human genes 0.000 description 1
- 102220063385 rs786204922 Human genes 0.000 description 1
- 102220192067 rs886057201 Human genes 0.000 description 1
- 229940085605 saccharin sodium Drugs 0.000 description 1
- 239000003352 sequestering agent Substances 0.000 description 1
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 description 1
- 229910000077 silane Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- HLBBKKJFGFRGMU-UHFFFAOYSA-M sodium formate Chemical compound [Na+].[O-]C=O HLBBKKJFGFRGMU-UHFFFAOYSA-M 0.000 description 1
- DZCAZXAJPZCSCU-UHFFFAOYSA-K sodium nitrilotriacetate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CC([O-])=O DZCAZXAJPZCSCU-UHFFFAOYSA-K 0.000 description 1
- 229940067741 sodium octyl sulfate Drugs 0.000 description 1
- 229960001922 sodium perborate Drugs 0.000 description 1
- 239000004328 sodium tetraborate Substances 0.000 description 1
- 235000010339 sodium tetraborate Nutrition 0.000 description 1
- WFRKJMRGXGWHBM-UHFFFAOYSA-M sodium;octyl sulfate Chemical compound [Na+].CCCCCCCCOS([O-])(=O)=O WFRKJMRGXGWHBM-UHFFFAOYSA-M 0.000 description 1
- YKLJGMBLPUQQOI-UHFFFAOYSA-M sodium;oxidooxy(oxo)borane Chemical compound [Na+].[O-]OB=O YKLJGMBLPUQQOI-UHFFFAOYSA-M 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 239000001384 succinic acid Substances 0.000 description 1
- 230000019635 sulfation Effects 0.000 description 1
- 238000005670 sulfation reaction Methods 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- FAGUFWYHJQFNRV-UHFFFAOYSA-N tetraethylenepentamine Chemical compound NCCNCCNCCNCCN FAGUFWYHJQFNRV-UHFFFAOYSA-N 0.000 description 1
- 150000004685 tetrahydrates Chemical class 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
- 229940038773 trisodium citrate Drugs 0.000 description 1
- 239000002753 trypsin inhibitor Substances 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/38—Products with no well-defined composition, e.g. natural products
- C11D3/386—Preparations containing enzymes, e.g. protease or amylase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/66—Enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/0005—Other compounding ingredients characterised by their effect
- C11D3/0078—Compositions for cleaning contact lenses, spectacles or lenses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Detergent Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40157395A | 1995-03-09 | 1995-03-09 | |
| US08/401,573 | 1995-03-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1183118A true CN1183118A (zh) | 1998-05-27 |
Family
ID=23588283
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN96193608A Pending CN1183118A (zh) | 1995-03-09 | 1996-03-06 | 具有降低的吸附作用和增加的水解作用的热酶变异体 |
Country Status (14)
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU1200997A (en) * | 1995-12-22 | 1997-07-17 | Helix Biotechnology Ltd | Thermostable proteolytic enzyme from thermoactinomyces thalpophilus thm1 |
| AU4773197A (en) * | 1996-11-04 | 1998-05-29 | Novo Nordisk A/S | Subtilase variants and compositions |
| JPH10204500A (ja) * | 1997-01-20 | 1998-08-04 | Soft Kyukyu Corp:Kk | 発泡錠剤洗浄剤 |
| ES2368718T3 (es) | 1997-10-23 | 2011-11-21 | Danisco Us Inc. | Variantes de subtilisina con múltiples sustituciones. |
| MA25044A1 (fr) * | 1997-10-23 | 2000-10-01 | Procter & Gamble | Compositions de lavage contenant des variants de proteases multisubstituees. |
| ATE428773T1 (de) * | 1998-12-18 | 2009-05-15 | Novozymes As | Subtilase enzyme der i-s2 untergruppe, mit einem zusätzlichen aminosäurenrest in einer aktiven schleifenregion |
| CA2355580C (en) * | 1998-12-18 | 2011-03-15 | Novozymes A/S | Subtilase enzymes of the i-s1 and i-s2 sub-groups having an additional amino acid residue in the active site loop region |
| US7319112B2 (en) | 2000-07-14 | 2008-01-15 | The Procter & Gamble Co. | Non-halogenated antibacterial agents and processes for making same |
| DE10153792A1 (de) | 2001-10-31 | 2003-05-22 | Henkel Kgaa | Neue Alkalische Protease-Varianten und Wasch- und Reinigungsmittel enthaltend diese neuen Alkalischen Protease-Varianten |
| DE10162728A1 (de) | 2001-12-20 | 2003-07-10 | Henkel Kgaa | Neue Alkalische Protease aus Bacillus gibsonii (DSM 14393) und Wasch-und Reinigungsmittel enthaltend diese neue Alkalische Protease |
| DE10162727A1 (de) | 2001-12-20 | 2003-07-10 | Henkel Kgaa | Neue Alkalische Protease aus Bacillus gibsonii (DSM 14391) und Wasch-und Reinigungsmittel enthaltend diese neue Alkalische Protease |
| JP5339672B2 (ja) * | 2006-07-03 | 2013-11-13 | 小林製薬株式会社 | 漂白洗浄剤組成物 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5116741A (en) * | 1988-04-12 | 1992-05-26 | Genex Corporation | Biosynthetic uses of thermostable proteases |
| DK316989D0 (da) * | 1989-06-26 | 1989-06-26 | Novo Nordisk As | Enzymer |
| DE69034159T2 (de) * | 1989-06-26 | 2005-02-17 | Unilever N.V. | Enzymatische Waschmittelzusammensetzungen |
| EP0405902A1 (en) * | 1989-06-26 | 1991-01-02 | Unilever Plc | Enymatic detergent compositions |
| ATE343636T1 (de) * | 1993-09-15 | 2006-11-15 | Procter & Gamble | Subtilisin bpn'-varianten mit verminderter adsorption und erhöhter hydrolyse |
-
1996
- 1996-03-04 IL IL11735296A patent/IL117352A0/xx unknown
- 1996-03-06 CN CN96193608A patent/CN1183118A/zh active Pending
- 1996-03-06 JP JP8527693A patent/JPH11501816A/ja active Pending
- 1996-03-06 MX MX9706846A patent/MX9706846A/es unknown
- 1996-03-06 AU AU51829/96A patent/AU5182996A/en not_active Abandoned
- 1996-03-06 ZA ZA961822A patent/ZA961822B/xx unknown
- 1996-03-06 EP EP96908663A patent/EP0815244A1/en not_active Withdrawn
- 1996-03-06 WO PCT/US1996/003009 patent/WO1996028558A1/en not_active Application Discontinuation
- 1996-03-06 HU HU9802069A patent/HUP9802069A3/hu unknown
- 1996-03-06 BR BR9607756A patent/BR9607756A/pt not_active Application Discontinuation
- 1996-03-06 CZ CZ972800A patent/CZ280097A3/cs unknown
- 1996-03-06 IN IN457DE1996 patent/IN187236B/en unknown
- 1996-03-06 CA CA002214578A patent/CA2214578A1/en not_active Abandoned
- 1996-03-07 MA MA24176A patent/MA23819A1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MA23819A1 (fr) | 1996-10-01 |
| IL117352A0 (en) | 1996-07-23 |
| HUP9802069A2 (hu) | 1998-12-28 |
| MX9706846A (es) | 1997-11-29 |
| AU5182996A (en) | 1996-10-02 |
| EP0815244A1 (en) | 1998-01-07 |
| ZA961822B (en) | 1996-09-11 |
| JPH11501816A (ja) | 1999-02-16 |
| WO1996028558A1 (en) | 1996-09-19 |
| IN187236B (enrdf_load_stackoverflow) | 2002-03-09 |
| CA2214578A1 (en) | 1996-09-19 |
| BR9607756A (pt) | 1999-03-30 |
| HUP9802069A3 (en) | 2000-11-28 |
| CZ280097A3 (cs) | 1998-01-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1151761A (zh) | 具有更低吸附性和更高水解能力的枯草溶菌素bpn’变异体 | |
| CN1057123C (zh) | 降低了吸附能力以及增加了水解能力的枯草杆菌蛋白酶bpn变体 | |
| CN1183809A (zh) | 具有降低吸附作用提高水解作用的蛋白酶k变异体 | |
| CN1177921C (zh) | 含有蛋白酶的漂白组合物 | |
| CN1163507C (zh) | 蛋白酶缀合物 | |
| CN1183119A (zh) | 具有降低的吸附作用和增加的水解作用的卡氏枯草杆菌蛋白酶变异体 | |
| CN1130462C (zh) | 碱性蛋白酶 | |
| CN1191347C (zh) | 含多取代蛋白酶变体的清洗组合物 | |
| CN1151187A (zh) | 枯草蛋白酶309突变体吸附作用降低而水解作用增强 | |
| CN1082999C (zh) | 含蛋白酶的洗涤组合物 | |
| CN1165615C (zh) | 枯草酶变种及组合物 | |
| CN1578832A (zh) | 新型碱性蛋白酶－变体和含有该种新型碱性蛋白酶－变体的洗涤剂 | |
| CN1183810A (zh) | 具有降低吸附增强水解作用的枯草杆菌蛋白酶dy变异体 | |
| CN1067265A (zh) | 含有一种芳基硼酸以抑制蛋白水解酶的液体洗涤剂 | |
| CN1606618A (zh) | Bacillus gibsonii(DSM 14393)的新型碱性蛋白酶以及包含该新型碱性蛋白酶的洗涤产品和清洁产品 | |
| CN1946841A (zh) | 新型碱性蛋白酶以及含有该新型碱性蛋白酶的洗涤剂和清洁剂 | |
| CN1608129A (zh) | 芽孢杆菌种(dsm 14392)的新型碱性蛋白酶以及包含该新型碱性蛋白酶的洗涤产品和清洁产品 | |
| CN1606626A (zh) | 芽孢杆菌种(dsm 14390)的新型碱性蛋白酶以及包含该新型碱性蛋白酶的洗涤产品和清洁产品 | |
| CN1606619A (zh) | Bacillus gibsonii (DSM 14391)的新型碱性蛋白酶以及包含该新型碱性蛋白酶的洗涤产品和清洁产品 | |
| CN1505679A (zh) | 新型碱性蛋白酶变体及含有该新型碱性蛋白酶变体的洗涤剂和清洗剂 | |
| CN1443236A (zh) | 从芽孢杆菌a7－7(dsm12368)中提取的新型淀粉分解酶以及含有该新型淀粉分解酶的洗涤剂和清洗剂 | |
| CN1447855A (zh) | 枯草杆菌酶 | |
| CN1541272A (zh) | 含杂合α-淀粉酶的洗涤剂和清洗剂 | |
| CN1548533A (zh) | 蛋白酶变体及组合物 | |
| CN1183118A (zh) | 具有降低的吸附作用和增加的水解作用的热酶变异体 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| REG | Reference to a national code |
Ref country code: HK Ref legal event code: GR Ref document number: 1057897 Country of ref document: HK |