CN118239847A - 具有神经保护作用的金刚烷胺硝酸酯化合物的制备方法 - Google Patents

具有神经保护作用的金刚烷胺硝酸酯化合物的制备方法 Download PDF

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Publication number
CN118239847A
CN118239847A CN202410514632.3A CN202410514632A CN118239847A CN 118239847 A CN118239847 A CN 118239847A CN 202410514632 A CN202410514632 A CN 202410514632A CN 118239847 A CN118239847 A CN 118239847A
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compound
structural formula
converted
follows
amantadine
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Chinese (zh)
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王玉强
孙业伟
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Guangzhou Magpie Pharmaceuticals Co Ltd
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Guangzhou Magpie Pharmaceuticals Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/04—Nitro compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P3/00—Drugs for disorders of the metabolism
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/68—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton
    • C07C209/76—Preparation of compounds containing amino groups bound to a carbon skeleton from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton by nitration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C211/34—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton
    • C07C211/38—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton containing condensed ring systems

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Diabetes (AREA)
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  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
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  • Urology & Nephrology (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN202410514632.3A 2014-05-29 2014-05-29 具有神经保护作用的金刚烷胺硝酸酯化合物的制备方法 Pending CN118239847A (zh)

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CN202410514632.3A CN118239847A (zh) 2014-05-29 2014-05-29 具有神经保护作用的金刚烷胺硝酸酯化合物的制备方法

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CN202410514632.3A CN118239847A (zh) 2014-05-29 2014-05-29 具有神经保护作用的金刚烷胺硝酸酯化合物的制备方法
CN201410235747.5A CN105294450B (zh) 2014-05-29 2014-05-29 具有神经保护作用的金刚烷胺硝酸酯化合物及其制备和医药应用

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CN202410514635.7A Pending CN118290279A (zh) 2014-05-29 2014-05-29 具有神经保护作用的金刚烷胺硝酸酯化合物的盐
CN202410514632.3A Pending CN118239847A (zh) 2014-05-29 2014-05-29 具有神经保护作用的金刚烷胺硝酸酯化合物的制备方法

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CN202410514635.7A Pending CN118290279A (zh) 2014-05-29 2014-05-29 具有神经保护作用的金刚烷胺硝酸酯化合物的盐

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EP (1) EP3150574B1 (enExample)
JP (1) JP6639483B2 (enExample)
CN (3) CN105294450B (enExample)
AU (1) AU2015267968B2 (enExample)
CA (1) CA2950452C (enExample)
ES (1) ES2946987T3 (enExample)
IL (1) IL249242B (enExample)
WO (1) WO2015180485A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106397119A (zh) * 2016-04-11 2017-02-15 上海博康精细化工有限公司 一种1，3-金刚烷二乙醇的制备方法
KR101659055B1 (ko) * 2016-05-10 2016-09-23 박소정 에피갈로카테킨 갈레이트 및 3,1-아다만탄디아세트산을 함유하는 알쯔하이머성 치매 치료 및 예방용 약학조성물
CN106344551B (zh) * 2016-08-22 2020-07-28 广州喜鹊医药有限公司 氨基金刚烷单硝酸酯类化合物在制备预防和治疗疾病药物中的应用
CN107412211A (zh) * 2017-08-04 2017-12-01 佛山喜鹊医药有限公司 氨基金刚烷胺单硝酸酯类化合物眼用组合物及其制剂和应用
WO2019104020A1 (en) * 2017-11-22 2019-05-31 Panorama Research, Inc. Aminoadamantyl nitrate compounds and their use to treat cns disorders
JP7296611B2 (ja) * 2018-08-03 2023-06-23 ビーエイチエヌ株式会社 一酸化窒素産生促進剤
CN109206317B (zh) * 2018-09-12 2021-07-09 青岛海蓝医药有限公司 一种金刚烷胺类硝酸酯衍生物的制备工艺
CN109172560B (zh) * 2018-10-15 2022-08-16 佛山喜鹊医药有限公司 氨基金刚烷硝酸酯类化合物或其药学上可接受的盐在预防和/或治疗肺部疾病中的应用
US20230218548A1 (en) * 2020-03-19 2023-07-13 Eumentis Therapeutics, Inc. Nitro-aminoadamantane compounds for the treatment of betacoronavirus infections
CN116725997A (zh) * 2022-03-01 2023-09-12 广州喜鹊医药有限公司 氨基金刚烷单硝酸酯类化合物在制药领域中的应用
CN117224520A (zh) * 2023-11-01 2023-12-15 广州喜鹊医药有限公司 (3-氨基-5-乙基金刚烷-1-基)硝酸甲酯及其药学上可接受的盐的医药用途

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US6444702B1 (en) * 2000-02-22 2002-09-03 Neuromolecular, Inc. Aminoadamantane derivatives as therapeutic agents
WO2002045710A1 (en) * 2000-12-07 2002-06-13 Neuromolecular Inc. Methods for treating neuropsychiatric disorders with nmda receptor antagonists
CN1125033C (zh) * 2001-08-29 2003-10-22 中国科学院广州化学研究所 美金刚胺盐酸盐的合成方法
CA2426492C (en) * 2002-05-31 2006-10-03 H. Lundbeck A/S A combination of an nmda-antagonist and acetylcholine esterase inhibitors for the treatment of alzheimer's disease
CN1400205A (zh) * 2002-08-30 2003-03-05 中国科学院广州化学研究所 美金刚胺盐酸盐的制备方法
US20090088367A1 (en) * 2004-05-10 2009-04-02 Burnham Institute For Medical Research Treatment of Insulin Resistance/Metabolic Syndrome to Alleviate the Risks of Dementia
WO2007065036A2 (en) * 2005-12-02 2007-06-07 Neuromolecular Pharmaceuticals, Inc. Therapeutic conjugates and methods of using same
US9242009B2 (en) * 2012-07-17 2016-01-26 The General Hospital Corporation Compositions and methods to treat neurodegenerative diseases

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Publication number Publication date
CN105294450A (zh) 2016-02-03
AU2015267968A1 (en) 2016-12-15
CN105294450B (zh) 2024-05-17
CA2950452A1 (en) 2015-12-03
WO2015180485A1 (zh) 2015-12-03
ES2946987T3 (es) 2023-07-31
EP3150574A4 (en) 2017-11-22
AU2015267968B2 (en) 2018-05-17
CA2950452C (en) 2020-03-31
IL249242A0 (en) 2017-02-28
EP3150574A1 (en) 2017-04-05
JP2017521482A (ja) 2017-08-03
IL249242B (en) 2020-03-31
JP6639483B2 (ja) 2020-02-05
CN118290279A (zh) 2024-07-05
EP3150574B1 (en) 2023-03-15

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