The objective of the invention is to provide a kind of reservation Margarita whole active component, contain the old and feeble cosmetics of novel anti of Margarita ultrafine powder and vitamin E.
The soft capsule that superfine compound pearl powder cosmetic disclosed by the invention is made up of 20%-30% Margarita ultrafine powder, 10%-15% vitamin E, 10%-20% vaseline, 1%-2% lanoline, 15%-18% emulsifying agent, 20%-40% oiliness wetting agent and 2%-3% daily essence.
Margarita ultrafine powder of the present invention is meant with comminution by gas stream and makes the Margarita powder of 98% powder diameter less than 1200 orders (10 microns).
Emulsifying agent of the present invention is meant Polyethylene Glycol series, Span series, Tween series, isopropyl myristate or their mixture.
Oiliness wetting agent of the present invention is meant lanonol, paraffin, squalane or their mixture.
Another purpose of the present invention is the preparation method that will disclose described superfine compound pearl powder cosmetic.
Superfine compound pearl powder cosmetic disclosed by the invention is made by following method:
(1) Margarita ultrafine powder preparation
After pretreated Margarita drying, use earlier ball mill to pulverize, sieve, after choose the following Margarita powder of 100 orders and carry out comminution by gas stream to 1200 order (10 microns), microwave sterilizating is standby.
(2) content preparation
Press formula ratio with vaseline, lanoline, emulsifying agent and liquid Paraffin heating and melting, make substrate, the cooling back is standby; The Margarita ultrafine powder of formula ratio, vitamin E added in the substrate stir evenly, use the colloid mill waterproof pulverization, sieve, make oil suspension; In suspension, add an amount of daily essence, stir evenly standby.
(3) soft capsule preparation
Get 2 parts of gelatin adding suitable quantity of water and make it imbibition, 1 part of glycerol heating back is added expansible gelatin, be heated with stirring to fusion.The filtration of shell glue is bled, remove part moisture content and foam.Use revolving die formula soft capsule maker, deployed content is pressed into the shell film, be wrapped in and wherein form soft capsule.The greasy dirt of flush away capsule surface, placing temperature is 25-30 ℃, relative humidity is dry in the drying room of 20%-25%, promptly makes soft capsule of superfine compound pearl powder.
Margarita is a kind of traditional beauty and skin care good merchantable brand, and Orally taken and externally all has good effect.Margarita is usually used in wound surface and ulcer,, nonirritant nontoxic to damaged skin and do not have anaphylactic reaction.Margarita contains several amino acids and trace element, and wound is risen to stimulate and Nutrition, promotes fibroblast and epithelial hyperplasia.To rabbit infective wound surface external application Margarita powder, its newborn granulation tissue all is a new capillary vessel, fills a large amount of fibroblasts and a small amount of collagen fiber therebetween, the plasma cell in addition different maturation period and macrophage etc.And the cellular control unit division is inactive, negligible amounts.The Margarita powder group can obviously shorten the time that wound surface grows flesh tissue.
Rabbit skin irritant test is carried out to medicine-feeding board Margarita powder in Shanghai Institute of Pharmaceutical Industry toxicological study chamber, and in rabbit skin, the result shows that this sample is to rabbit skin nonirritant through continuous week coating Margarita powder.
Timid speckle effect studies show that Margarita powder has the timid speckle effect of tangible skin care to Margarita powder in Xiyuan Hospital, Chinese Medicine Academy of China, can make the female subjects chloasma area 21.38 ± 28.89mm that on average descends
2, the color total effective rate that obviously shoals reaches 73.33%.
As cosmetics, vitamin E has skin moistening, protectiving ultraviolet damage, the peroxidization that reduces lipoid and the effect of glabrous skin.Using the vitamin E of 5% concentration at epidermis, can make the moisture of skin evaporation capacity reduce 19%, is a kind of ideal emollient.Can eliminate after the vitamin E Transdermal absorption on the skin owing to ultraviolet light-B shines the free radical that produces, and can suppress the cell membrane lipid peroxidation forms, prevent pigment and lipofuscin deposition that these peroxide cause, thus the process of delaying human body skin aging.
Vitamin E also is widely used in dermatosis, and some chronic skin disease can be treated by local application, reduces cicatrization in wound healing process, has the antiinflammatory action that reduces erythema, improves swelling.There is the disease of significant curative effect to have: lupus erythematosus, dermatomyositis, chilblain, eczema, palm cuticle disease, diabetic dermatosis etc.
Capital Medical College uses the vitamin E clinical treatment, and xerosis cutis, rhagadia manus et pedis, ichthyosis, seborrheic dermatitis total effective rate are reached 96%; It is 86% that chloasma, senile plaque, wrinkle are eliminated total effective rate.Tongji Medical Univ's experiment shows, adds vitamin E and can improve the epidermis cell vigor in to the treatment of acne, seborrheic dermatitis, chloasma and freckle, and delaying cell aging moistens the nutrition skin, strengthens the effect of treatment and beauty treatment.After the Most patients treatment, it is plentiful, ruddy, smooth, delicate that skin becomes.Because vitamin E except that keeping capillary permeability, also has stimulation to hypophysis cerebri-adrenal cortex, to the recovery of denatured collagen fiber and elastic fibers and keep normal myoarchitecture and function has certain effect.
Margarita powder and vitamin E are made the compound external-use preparation, be used for various dermatosiss clinically and be used to prevent xerosis cutis, chap, skin care, preserving moisture makes skin tender bright and clean etc.Through each disease is planted 176 routine clinical observation on the therapeutic effect, the effective percentage chloasma is 93.3% (using for 4 weeks), freckle is 90.5% (using for 4 weeks), and psoriasis is 75% (using for 6 weeks), and erythema multiforme is 77.7% (using for 4 weeks), chilblain is 77.0% (using for 3 weeks), acne is 75% (using for 4 weeks), scleroderma 100% (using for 4 weeks), exfoliative dermatitis 100% (using for 3 weeks), old keratotic plaque 85% (using for 4 weeks), pityriasis rubra pilaris and discoid lupus erythematosus are 100%.Studies show that the medicine percutaneous has improved serum vitamin E concentration after absorbing, suppress the interior free yl reaction, play anti-aging effects; Moreover its protection cell endoperoxides enzymatic activity, reduce the endochrome calmness; It can promote blood capillary proliferation in addition, improves local blood circulation and oxygen supply, promote wound healing, and its adrenocortical hormone sample interaction energy disappears erythra rapidly.Contain several amino acids in the Margarita powder, wherein 7 kinds is that human body is necessary, also is rich in other trace element, can promote the metabolism of body, human body immunity improving function, wrinkle resistant and slow down aging.
Margarita ultrafine powder adopts the physical method of comminution by gas stream, keep its active component to greatest extent, through superfine grinding 98% powder diameter less than 10 microns, and general ball mill pulverizing particle diameter is greater than 75 microns, its particle diameter is less than human capillary vessel's diameter, the effect of Transdermal absorption is more obvious, is decomposed, absorbs and utilize by human body apace easily.Vitamin E is a kind of very strong antioxidant, and human body skin is had the effect of moistening, and acne, senile plaque, xerosis cutis and ultraviolet injury are all had better curative effect.In cosmetics, add vitamin E and can promote skin metabolism, reduce lipid peroxidation, prevent xerosis cutis, strengthen the effect of glabrous skin.Margarita ultrafine powder and vitamin E compatibility are used, can bring into play the two complementary effect.Than pure Margarita powder, this product has stronger removing oxygen-derived free radicals, directly replenishes the required nutrient of skin, function in delaying senility; Compare with the vitamin E of single-prescription, this product has increased timid speckles, beautification and white again, has improved the effect of skin matter, and product of the present invention has had both the function of Margarita powder and vitamin E, and prescription is novel, and effect is obvious, has special advantages.Adopt soft capsule dosage form, be convenient to consumer more and carry and use.
China 21 century will be to " aging society " transition, and old people's health care problem will be the big problem that the mankind face, and the anti-aging beauty-care product that are rich in bioactive substance will be to delay one of old and feeble important content of human physiology and psychology.The inherent advantage of superfine compound pearl powder cosmetic performance Chinese medicine uniqueness of the present invention, except local skin being had the good effect, medicine enters blood circulation by Transdermal absorption, for body certain effect is arranged also, makes the trophism of this product and functionally is able to better embodiment.The natural safety of superfine compound pearl powder cosmetic active component of the present invention is carried, easy to use, and effect is remarkable, and enforcement of the present invention will be satisfied the demand of people to improving the quality of living and U.S. being pursued.
Embodiment 1
Prescription
Margarita ultrafine powder 250g
Vitamin E 125g
Vaseline 156g
Lanoline 18g
PEG400 63g
Span60 50g
Span80 13g
Liquid Paraffin 300g
Daily essence 25g
(1) Margarita ultrafine powder preparation
After pretreated Margarita drying, use earlier ball mill to pulverize, sieve, after choose the following Margarita powder of 100 orders and carry out comminution by gas stream to 1200 order, microwave sterilizating is standby.
(2) content preparation
Press formula ratio with vaseline, lanoline, emulsifying agent and liquid Paraffin heating and melting, make substrate, the cooling back is standby; The Margarita ultrafine powder of formula ratio, vitamin E added in the substrate stir evenly, use the colloid mill waterproof pulverization, sieve, make oil suspension; In suspension, add an amount of daily essence, stir evenly standby.
(3) soft capsule preparation
Get 500g gelatin adding suitable quantity of water and make it imbibition, 250g glycerol heating back is added expansible gelatin, be heated with stirring to fusion.The filtration of shell glue is bled, remove part moisture content and foam.Use revolving die formula soft capsule maker, deployed content is pressed into the shell film, be wrapped in and wherein form soft capsule.The greasy dirt of flush away capsule surface, placing temperature is 25-30 ℃, relative humidity is dry in the drying room of 20%-25%, promptly makes soft capsule of superfine compound pearl powder.Every capsules contains content 0.4g.
Embodiment 2
Prescription
Margarita ultrafine powder 200g
Vitamin E 140g
Vaseline 180g
Lanoline 11g
PEG400 45g
Span60 65g
Span80 34g
Liquid Paraffin 200g
Squalane 100g
Daily essence 25g
Method by embodiment 1 makes soft capsule of superfine compound pearl powder, and every capsules contains content 0.3g.
Embodiment 3
Prescription
Margarita ultrafine powder 300g
Vitamin E 100g
Seed of Radix Oenotherae erythrosepalae oil 50g
Vaseline 110g
Lanoline 15g
PEG400 85.5g
Span60 35.5g
Span80 24g
Isopropyl myristate 150g
Squalane 100g
Daily essence 30g
Method by embodiment 1 makes soft capsule of superfine compound pearl powder, and every capsules contains content 0.5g.