CN107375437A - A kind of anti acne of traditional Chinese medicine composition and its application - Google Patents
A kind of anti acne of traditional Chinese medicine composition and its application Download PDFInfo
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- CN107375437A CN107375437A CN201710763405.4A CN201710763405A CN107375437A CN 107375437 A CN107375437 A CN 107375437A CN 201710763405 A CN201710763405 A CN 201710763405A CN 107375437 A CN107375437 A CN 107375437A
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Abstract
The invention discloses a kind of anti acne of traditional Chinese medicine composition and its application.The pharmaceutical composition includes：Gotu Kola P.E, Baical Skullcap root P.E, vitamin E, caryophyllus oil, licorice, shrubby sophora extract, hydrolyzed pearl, borneol, make external preparation with appropriate matrix and form.Chinese medicine composition provided by the invention has clearing heat and promoting diuresis, the effect of removing toxicity for detumescence, with good suppression propionibacterium acnes growth, the multi-efficiencies such as drug resistance, anti-acne scar proliferation, anti-pigmentation, anti-inflammatory, analgesia, moisturizing, regulation grease balance are not produced, anti-acne effect is obvious, acne can thoroughly be effected a radical cure, non-relapse after healing, and having no toxic side effect, anti-acne not trace.4 weeks total effective rates of traditional Chinese medicine composition for treating acne of the present invention are 100%, cure patient's no relapse；For pigmentation total effective rate up to 85.71%, curative effect is better than tretinoin cream, does not observe obvious adverse reaction after treating acne.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, and in particular to a kind of Chinese medicine composition or cosmetics group with acne-removal function
Compound and its application.
Background technology
Acne is commonly called as whelk, acne, dark sore, and traditional Chinese medical science ancient times claim face sore, acne.It is a kind of slow of pilosebaceous unit
Property inflammatory dermatoses, clinical manifestation is to be apt to occur in the acne of face, papule, warts, tubercle, the polymorphy skin lesion such as tumour to be special
Point.Acne protracted inflammation is obstinate, and some patientss skin lesion can leave erythema or pigmentation, it is necessary to which the long period could be extensive after disappearing
Multiple recovery from illness, Hypertrophic or atrophic scar is easily left after developing into the more serious patients with acne such as purulence trace, tubercle, tumour more,
If treating or treating not in time bad, face can be caused rugged, have a strong impact on patient's appearance, increase mental pressure,
The quality of life of patient is set to have a greatly reduced quality.Acne is dermatology common disease, and the incidence of disease is higher.According to statistics, have in Adolescent male
95%th, women has 85% to suffer from different degrees of acne, and China's adolescent acne incidence of disease is up to more than 50%.Scar after acne
Incidence is 7.1%, and 12 years old age group scar incidence is 0.5%, thereafter scar incidence by year increase.
At present, the pathogenesis of acne does not illustrate completely yet.Modern medicine believes that, the pathogenesis of acne is mainly and sebum
Hypersecretion, hair week hyperkeratinization, propionibacterium acnes breeding and inflammatory reaction four factors are related, and in pilosebaceous follicle
Propionibacterium acnes amount reproduction an important factor for being pathogenesis of acne.There are the order of severity and sebaceous glands that scholar thinks acne
Secretory volume is relevant, and the nutriment of hypersteatosis then propionibacterium acnes is more.Propionibacterium acnes (P.acnes) is to settle down
Normal flora in human body skin and mucous membrane, belongs to dialister bacterium, and its growth is to be used as to support by the triacylglycerol in sebum
Material, and go esterified content of fatty acid directly proportional to the quantity of bacterium in sebum.It is simultaneously a large amount of caused by propionibacterium acnes
Ectoenzyme and the cellular immunity of propionibacterium acnes mediation all enhance the inflammatory reaction of acne, are to trigger acne inflammatory reaction
The main reason for.
In order to which Clinical practice is simple and convenient,《Chinese acne treatment guide (2014 revised edition)》Main Basiss skin lesion property will
Acne is divided into 3 degree and 4 grades：Slightly (I grade)：Only acne；Moderate (II grade)：Inflamed papules；Moderate (III grade)：Warts；Severe
(IV grade)：Tubercle, tumour.
At present, in the market is various for the medicament categories for treating acne, and Western medicine class has retinoid, antibioticses, most often
Antibiosis is known as macrolides, Tetracyclines or clindamycin etc..Erythromycin is macrolides representativeness antibiotic, right
Propionibacterium acnes has very strong inhibitory action.But research shows the hair of propionibacterium acnes drug resistance in patients with acne now
Raw rate is rising year by year, and the drug resistance of erythromycin is the most common, and tetracycline resistant is secondly.And it is resistance to intersection to be also present in erythromycin
Medicine, cause curative effect of medication worse.And after long-term use of antibiotic, it may occur in which that the poison such as dry skin, erythema, shouting pain, itch is secondary
Effect.It can be seen that though Western medicine has certain curative effect, drug resistance is also easy to produce mostly, it is impossible to thoroughly effects a radical cure acne, and toxic side effect is big.Control
It is various to treat the Chinese patent drug species of acne, but it is slow to work mostly, course for the treatment of length, and pigmentation caused by acne and scar are treated
Imitate bad.
It can be seen that the defect of the medicine of existing treatment acne is to be also easy to produce propionibacterium acnes drug resistance, can not thoroughly effect a radical cure
Acne, and to scar caused by acne and pigmentation unsatisfactory curative effect, therefore, it is necessary to develop anti-drug resistance, curative effect more preferably
Anti-acne medicine.
Patent of invention：A kind of Whelk-eliminating paste based on high-purity herb extract and preparation method thereof (application number:
CN201610112859.0, the applying date:2016.03.01), disclose with：Centella, giant knotweed, radix scutellariae, tealeaves, glycyrrhiza glabra,
Flos Chrysanthemi, rosemary, white willow, spiked gingerlily fruit, the red sage root, gentian, loguat leaf, licorice, honeysuckle flowers, marigold, daisy are prescription
Herb extract Whelk-eliminating paste.But have no document report with：It is Gotu Kola P.E, Baical Skullcap root P.E, vitamin E, caryophyllus oil, sweet
Careless extract, shrubby sophora extract, hydrolyzed pearl, borneol are used for anti-acne externally used paste for the Chinese medicine composition of prescription.
The content of the invention
The purpose of the present invention is to be directed to current propionibacterium acnes drug resistance, and acne can not be effected a radical cure thoroughly, is passed through again after healing
Often recur and be also easy to produce pigmentation and the above-mentioned deficiency of scar, there is provided a kind of Chinese medicine composition of anti-acne and preparation method thereof.
Anti acne of traditional Chinese medicine composition of the present invention is made up of plurality of Chinese extract, according to traditional Chinese medical theory prescription, has clearing heat and promoting diuresis, removing toxic substances
The effect of detumescence, have and suppress propionibacterium acnes growth well, do not produce drug resistance, anti-acne scar proliferation, anti-pigment
The multi-efficiencies such as calmness, anti-inflammatory, analgesia, moisturizing, regulation grease balance, anti-acne effect is obvious, acne can be thoroughly effected a radical cure, after healing
Do not recur, and have no toxic side effect, anti-acne not trace.
To realize the purpose of the present invention, the technical scheme that the present invention takes is：
A kind of anti acne of traditional Chinese medicine composition, it is made up of the raw material of following portions by weight：
15~40 parts of Gotu Kola P.E, 10~30 parts of Baical Skullcap root P.E, 5~20 parts of vitamin E, caryophyllus oil 5~20
Part, 5~10 parts of licorice, 2~8 parts of shrubby sophora extract, 1~5 part of hydrolyzed pearl, 0.5~3 part of borneol
Preferably, above-described anti acne of traditional Chinese medicine composition, it is made up of the raw material of following portions by weight：
40 parts of Gotu Kola P.E, 10 parts of Baical Skullcap root P.E, 20 parts of vitamin E, 20 parts of caryophyllus oil, licorice 5
Part, 2 parts of shrubby sophora extract, 5 parts of hydrolyzed pearl, 0.5 part of borneol.
Preferably, above-described anti acne of traditional Chinese medicine composition, it is characterised in that it is by following portions by weight
Raw material is made：
15 parts of Gotu Kola P.E, 10 parts of Baical Skullcap root P.E, 20 parts of vitamin E, 5 parts of caryophyllus oil, licorice 10,
8 parts of shrubby sophora extract, 1 part of hydrolyzed pearl, 3 parts of borneol.
Preferably, above-described anti acne of traditional Chinese medicine composition, it is made up of the raw material of following portions by weight：
30 parts of Gotu Kola P.E, 30 parts of Baical Skullcap root P.E, 10 parts of vitamin E, 15 parts of caryophyllus oil, licorice 8
Part, 6 parts of shrubby sophora extract, 4 parts of hydrolyzed pearl, 2 parts of borneol.
Preferably, above-described anti acne of traditional Chinese medicine composition, it is made up of the raw material of following portions by weight：
25 parts of Gotu Kola P.E, 20 parts of Baical Skullcap root P.E, 10 parts of vitamin E, 10 parts of caryophyllus oil, licorice 7,
5 parts of shrubby sophora extract, 2 parts of hydrolyzed pearl, 1 part of borneol
Preferably, above-described anti acne of traditional Chinese medicine composition, the Gotu Kola P.E contain asiaticosid and hydroxyl
Base asiaticosid, which amounts to, is no less than 60%；Baical Skullcap root P.E must not be less than 85% containing scutelloside；Caryophyllus oil is no less than containing eugenol
80%；Licorice is no less than 70% containing dipotassium glycyrrhizinate；Shrubby sophora extract is no less than 90% containing oxymatrine.
Preferably, the preparation method of the Gotu Kola P.E is：The preparation method of the Gotu Kola P.E
For：Centella is taken, with the 75% ethanol heating and refluxing extraction 2 times of 10 times of volumes of medicinal material weight, 1 hour every time, merging filtrate,
Filtrate recycling ethanol, it is concentrated into equivalent to raw medicinal herbs 1g/mL, adds 4 times of amount water, stirring while adding, refrigerated overnight, centrifuge, centrifugation
Liquid is 2.0 with 2mol/L salt acid for adjusting pH value, refrigerated overnight, centrifugation, extracting centrifugal liquid, upper macroporous resin column, is first washed with water
Resin column, then with the ethanol of volumetric concentration 30% to wash resin column, finally with the ethanol elution of volumetric concentration 50%, collect 50% second
Alcohol eluen；Ethanol is recovered under reduced pressure to without alcohol taste in eluent, dry, pulverize and produces；
The preparation method of the Baical Skullcap root P.E is：Radix scutellariae is taken, the decocting of dosing material 12 times of volumes of weight is boiled 1 to 3 time, is closed
And decocting liquid, concentration, with salt acid for adjusting pH value to 1.0~2.0,80 DEG C of insulations, stand, filtration, sediment adds suitable quantity of water to stir evenly, and uses
Sodium hydroxide solution adjusts pH value to 7.0, adds ethanol to be stirred to dissolve, and filters, filtrate with salt acid for adjusting pH value to 1.0~2.0,
60 DEG C of insulations, stand, filtration, and precipitation is washed till pH value to 7.0 with water and ethanol successively, waves most ethanol, concentrates, dries, produce；
The preparation method of caryophyllus oil is：The dry flower of plant clove of myrtaceae is taken, through steam distillation, must be volatilized
Oil；
The preparation method of licorice is：Extracting liquorice, run through, cut into slices, add 70 DEG C of extractions of water three times, 2 hours every time, close
And extract solution, standing overnight makes precipitation, takes supernatant, and dense HCl is adjusted to pH value to 3.0, stands, precipitation filtering, precipitate with water-soluble
Solution, add potassium hydroxide solution, 50-70 DEG C of reaction 3-5 hour；Concentration, dry, produce；
The preparation method of shrubby sophora extract is：Take the ethanol solution (ammonification in 1000ml ethanol of kuh-seng volumetric concentration 80%
Water 20ml) extract 2 times, 1 hour every time, filtrate merged, and is concentrated into no alcohol taste, and then plus 3 times of amount water dilute, and add hydrochloric acid tune pH extremely
3.0, stand, filtering, filtrate is extracted 3 times with ether, and water layer adjusts PH to 11 with ammoniacal liquor, is then extracted with ethyl acetate 3 times, is closed
And acetic acid ethyl acetate extract, it is recovered under reduced pressure, residue is dissolved with ethanol, adds hydrogen peroxide, and reaction is complete, concentrates, and dries, dried object
Dissolved by heating with hot ether, recrystallize and produce；
The preparation method of hydrolyzed pearl is：Take pearl is ground fine powder is made, acid adding (preferably hydrochloric acid, sulfuric acid) relaxes water
Solution, deacidification, concentration, dry, pulverize, produce.
A kind of Chinese medicine preparation of anti-acne, external application system is made in described Chinese medicine composition and pharmaceutically acceptable auxiliary material
Agent.
The Chinese medicine preparation of above-described anti-acne, the formulation of described preparation is ointment, cream, gel, is put on the skin
Agent, paint, plastics, tincture, emplastrum or Babu plaster.
Application of the anti acne of traditional Chinese medicine composition of the present invention in the medicine or/and cosmetics for anti-acne is prepared.
Beneficial effect：Compared to the prior art the present invention, has advantages below：
1st, the Chinese traditional medicine composition formula that the present invention uses, is screened, prolonged application does not produce drug resistance and poison by many experiments
Side effect.
2nd, animal pharmacodynamics test shows, Chinese medicine composition provided by the invention can significantly improve Acne Model animal disease
Shape, suppress thickening for rabbit ear, reduce acne pore aperture, extruding has no whiteness, touches smooth pliable.Chinese medicine group of the present invention
Compound has significant antiinflammatory action, can significantly reduce Acne Model animal rabbit auricle weight, reduces IL-6 and IL-1 α water in serum
It is flat.Chinese medicine composition of the present invention can significantly improve the microvascular perfusion amount at rabbit ear coating position, and improving micro_circulation effect is obvious.
3rd, animal pharmacodynamics test shows it is also shown that Chinese medicine composition of the present invention can significantly improve the Hypertrophic model of rabbit ear and move
Thing symptom, makes hyperplastic scar soften, Inhibiting proliferation, and color is thin out.Chinese medicine composition of the present invention can improve MDA in tissue and contain
Amount, while scar model rabbit ear tissue hyperplasia index (HI) and fibroblast surface density (NV) are significantly reduced, illustrate the present invention
Chinese medicine composition can induce cell and lipid peroxidation occur, and makes apoptosis of fibroblasts, suppresses fibroblastic hyperplasia, have
Suppress the effect of scar growth.
4th, clinical research shows, Chinese medicine composition of the present invention is 100% to 4 weeks total effective rates of acne treatment, after healing not
Recurrence.Have no adverse reaction appearance in therapeutic process.Pigmentation total effective rate reaches after traditional Chinese medicine composition for treating acne of the present invention
85.71%, curative effect is better than tretinoin cream, does not observe obvious adverse reaction.
5 and the present invention shown by Dismemberment study, Gotu Kola P.E, Baical Skullcap root P.E, caryophyllus oil, kuh-seng extraction
Thing, hydrolyzed pearl and borneol are indispensable important component, and after lacking any component simply, curative effect is significant lower.Therefore,
Each raw material composition of the present invention is optimal raw material composition.
Embodiment
The present invention is further illustrated below by the mode of embodiment, but does not therefore limit the present invention to described reality
Apply among a scope.After the present invention has been read, modification of the those skilled in the art to the various unsubstantialities of the present invention is equal
Fall within the application appended claims limited range.
Gotu Kola P.E, Baical Skullcap root P.E, vitamin E, caryophyllus oil, radix glycyrrhizae extraction used in example 1 below to 4
Thing, shrubby sophora extract and hydrolyzed pearl, the method described using claim 7 or specification are prepared.
Embodiment 1
1st, a kind of Chinese medicine composition of anti-acne, it is made up of the raw material of following portions by weight：
40 parts of Gotu Kola P.E, 10 parts of Baical Skullcap root P.E, 20 parts of vitamin E, 20 parts of caryophyllus oil, licorice 5
Part, 2 parts of shrubby sophora extract, 5 parts of hydrolyzed pearl, 0.5 part of borneol.
2nd, the preparation process of Chinese medicine composition gelata of the present invention
Ethyl hydroxy benzoate 3g is taken, adds propane diols 90g to make dissolving, adds water 1800g, stir, carbomer 45g is added, grinds
Mill, makes complete swelling, standby；Triethanolamine 67.5g separately is taken, adds water 300g to make dissolving, adds above-mentioned carbomer point while stirring
In dispersion liquid, grind well, obtain bare substrate, it is standby；Separately take Gotu Kola P.E 40g, Baical Skullcap root P.E 10g, vitamin E 20g, fourth
Sesame oil 20g, licorice 5g, shrubby sophora extract 2g, hydrolyzed pearl 5g, borneol 0.5g, glycerol adding 292g and water 300g, grind
Mill makes to be completely dispersed, and adds in above-mentioned bare substrate, and grinding is uniform, produces 3000g, Chinese medicine composition content is：3.42%.
Embodiment 2
1st, a kind of Chinese medicine composition of anti-acne, it is made up of the raw material of following portions by weight：
30 parts of Gotu Kola P.E, 30 parts of Baical Skullcap root P.E, 10 parts of vitamin E, 15 parts of caryophyllus oil, licorice 8
Part, 6 parts of shrubby sophora extract, 4 parts of hydrolyzed pearl, 2 parts of borneol.
2nd, auxiliary material
3rd, the preparation method of Chinese medicine composition cream of the present invention
By above-mentioned prescription Chinese medicine composition and auxiliary material (40 parts of dromisol；160 parts of propane diols；30 parts of triethanolamine；Dimension life
Plain C30 parts；180 parts of glycerin monostearate；220 parts of octadecyl alcolol；30 parts of beeswax；200 parts of liquid wax；10 parts of parabens；Go
1200 parts of ionized water), well mixed to produce cream, Chinese medicine composition content is：4.76%.
Embodiment 3
1st, a kind of Chinese medicine composition of anti-acne, it is made up of the raw material of following portions by weight：
25 parts of Gotu Kola P.E, 20 parts of Baical Skullcap root P.E, 10 parts of vitamin E, 10 parts of caryophyllus oil, licorice 7
Part, 5 parts of shrubby sophora extract, 2 parts of hydrolyzed pearl, 1 part of borneol.
2nd, the preparation process of Chinese traditional medicine composition composition liniment of the present invention
(1) by 600 parts of polyethylene glycol-800；200 parts of triethanolamine；200 parts of glycerine；300 parts of deionized water, add reaction
In kettle, 50 DEG C are heated to, stirring is miscible, makes to be completely dissolved.
(2) prescription Chinese medicine composition (25 parts of Gotu Kola P.E, 20 parts of Baical Skullcap root P.E, dimension are added in above-mentioned material
Raw plain 10 parts of E, 10 parts of caryophyllus oil, 7 parts of licorice, 5 parts of shrubby sophora extract, 2 parts of hydrolyzed pearl, 1 part of borneol), ethanol
500 parts, it is sufficiently stirred, makes it well mixed, can also add essence simultaneously and liniment is prepared, Chinese medicine composition content is：
4.26%.
Embodiment 4
1st, a kind of Chinese medicine composition of anti-acne, it is made up of the raw material of following portions by weight：
15 parts of Gotu Kola P.E, 10 parts of Baical Skullcap root P.E, 20 parts of vitamin E, 5 parts of caryophyllus oil, licorice 10
Part, 8 parts of shrubby sophora extract, 1 part of hydrolyzed pearl, 3 parts of borneol.
2nd, the preparation process of Chinese medicine composition plastics of the present invention
By prescription Chinese medicine composition (15 parts of Gotu Kola P.E, 10 parts of Baical Skullcap root P.E, 20 parts of vitamin E, caryophyllus oil 5
Part, 10 parts of licorice, 8 parts of shrubby sophora extract, 1 part of hydrolyzed pearl, 3 parts of borneol) after the dissolving of 100 part of 70% ethanol, add
300 parts of dibatyl phithalate of neck and ethanol continue dissolving stirring, add 110 parts of polyvinyl formal acetal, side edged stirs
Mix, to whole dissolvings, then add 400 part of 70% appropriate amount of ethanol, produce, Chinese medicine composition content is：4.86%.
Example effects 1
The effect of traditional Chinese medicine composition for treating rabbit ear acne animal model of the present invention.
1st, experimental method
Animal packet：It is male from regular grade new zealand rabbit 70, weight (2.0 ± 0.2Kg), normal temperature environment
Lower raising.After adaptability is raised 1 week, modeling group 60, blank control 10 are randomly divided into by body weight, to 60 New Zealand of modeling group
Rabbit carries out the modeling of 2 weeks by a definite date, and after model is successfully prepared, 60 new zealand rabbits are divided into 6 groups, respectively model comparison by body weight
Group, positive controls (Clindamycin Gel) and the high, medium and low dosage group of the Chinese medicine composition gelata of the embodiment of the present invention 1, gel
Matrix group, every group 10.
Modeling：Syrinx exit 2cm × 2cm scopes on the inside of rabbit auris dextra, it is daily to apply 2% liquor carbonis detergens 1 time, every time
0.5~1mL, continuous 14d.Propionibacterium acnes strain is directly inoculated in raw shuttle spore bacterium culture medium, is placed in anaerobism bag, 37 DEG C of trainings
Observed after supporting 48h.It is 6 × 10 to wash lower lawn adjustment propionibacterium acnes using physiology salt8/ mL, it is standby.The next day rabbit ear it is intracutaneous
Propionibacterium acnes bacterium solution is injected, if visible tumour occur can stop being inoculated with.After 2 weeks, 2 model control groups are randomly selected
Rabbit extrusion follicular orifice white content carries out streak inoculation and determines whether to infect for propionibacterium acnes.And modeling position is beaten
Hole takes skin biopsy to carry out HE dyeing and determines whether model preparation succeeds.
Administration：Each group smears corresponding medicine 0.5g in modeling position 2cm × 2cm scopes, one time a day, after 8h is administered
Use warm water cleaning.The high, medium and low dosage group of the Chinese medicine composition gelata of the embodiment of the present invention 1 gives 6%, 3.42% respectively,
The gel of the Chinese medicine composition of 1.5% weight/mass percentage composition, positive drug group give 1% Clindamycin Gel.Gel-type vehicle
Group gives the Blank gel matrix of equivalent, and blank group and model group give normal saline.
Indexs measure：After last dose, rabbit ear is measured using laser-Doppler circulating instrument and smears surface microcirculation at medicine
Microvascular perfusion amount (PU).Auricle is prepared in the punching of coating position using 5mm card punch, and measures its quality.Take modeling position
After the formaldehyde of ear 10% is fixed, specimens paraffin embedding slices, liver histopathological analysis is treated after HE dyeing.Heart extracting blood, centrifuging and taking serum
By ELISA kit requirement measure IL-1 α, IL-6.
2nd, experimental result
2.1 visual inspection
Overview normal group rabbit auricle is belittled, and soft, capillary is clear, the visible clear cell hair follicle in inner side and fibre
Fine, soft fur is sent out.Model group rabbit ear substantially thickens, and tactile abnormal rough, pore is thick, follicular orifice visible black color keratotic plug, and extruding is visible
White content.Compared with model group, the high, medium and low dosage group of the Chinese medicine composition gelata of the embodiment of the present invention 1 can different journeys
The reduction rabbit ear of degree thickens, and reduces pore aperture, and extruding has no whiteness, touches smooth pliable.
2.2 pathological observation
Model group：Epidermal hyperkeratosis thickens, stratum granulosum, acanthosis, and follicular orifice is full of angling material, follicular orifice due to
Excessive content and expand protrusion, infundibulum of hair follicle portion rupture, it is seen that inflammatory cell infiltration.The visible epidermis of each administration group thickens
Reduce, hair follicle gyalectiform expansion structure disappears, dermal inflammation Leukopenia, and stratum granulosum, acanthosis increase and subtracted with dosage
It is few.The Chinese medicine composition gelata of the embodiment of the present invention 1 is high, several acerous compounds of middle dose group hair follicle, and the visible hair follicle of low dose group is few
Angulation compound matter.Positive drug group keratinization of epidermis thickens obvious reduction, and stratum granulosum and spinous layer are thinning, and institutional framework is similar normal
Group.Each group is administered to contrast with model group, can mitigate illness to varying degrees.
The influence of 2.3 pairs of inflammation indexs of correlation
The high, medium and low dosage group of the Chinese medicine composition gelata of the embodiment of the present invention 1 and positive drug group rabbit auricle weight, serum
Middle IL-6 has conspicuousness to reduce (P ＜ 0.01) horizontally relative to model group, the Chinese medicine composition gelata of the embodiment of the present invention 1
IL-1 α have conspicuousness to reduce (P ＜ 0.01) in high, middle dose group and positive drug group rabbit anteserum.It is shown in Table 1.
1 Chinese medicine composition of the present invention of table to inflammation index of correlation influence (N=10)
Note：Compared with model group, * P ＜ 0.05, * * P ＜ 0.01.
The influence of 2.4 pairs of rabbit auricular microcirculation blood perfusion amounts
Compared with model group, the Chinese medicine composition gelata of the embodiment of the present invention 1 is high, medium and low and positive drug group can show
The microvascular perfusion amount (P ＜ 0.01) for improving rabbit ear coating position of work, improving micro_circulation effect is obvious, the embodiment of the present invention 1
Chinese medicine composition gelata high dose group therapeutic effect is slightly better than positive drug.It is shown in Table 2.
2 Chinese medicine composition of the present invention of table to rabbit auricular microcirculation blood perfusion amount influence (N=10)
Example effects 2
The effect of Chinese medicine composition of the present invention is to rabbit ear hyperplastic scar.
1st, experimental method
Animal packet：It is male from healthy adult Japan large ear rabbit 70, weight (2.0 ± 0.2Kg), often
Raised under warm environment.After adaptability is raised 1 week, modeling group 60, blank control 10 are randomly divided into by body weight, to modeling group 60
Only adult Japan large ear rabbit carries out the modeling of 2 weeks by a definite date, and after model is successfully prepared, 60 new zealand rabbits are divided into 6 by body weight
Group, respectively model control group, positive controls (asiaticoside emulsifiable paste) and the Chinese medicine composition cream of the embodiment of the present invention 2 height,
In, low dose group, emulsifiable paste matrix group, every group 10.
Animal model：From healthy adult Japan large ear rabbit 60, sub-cage rearing, observation one week before testing.Reference
The method of MorrisShi and document is simultaneously subject to improvement and establishes rabbits hypertrophic scars model.It is preoperative to be noted with 10% chloraldurate abdominal cavity
Penetrate anesthesia, dosage 3.5mL/kg, under aseptic technique, be a diameter of 0.8cm's in rabbit ear facies ventralis with marking pen
Circle mark, scalpel take down rabbit ear full thickness skin and perichondrium, sterile gauze wrapping hemostasis along label range.Next day removes yarn
Cloth, surface of a wound exposure is kept drying, its self-heal is treated under nature.The Post operation about 18d surface of a wound completes epithelialization.Use simultaneously
The each wound surface of vernier caliper measurement is more than to dorsal skin thickness and its noninvasive injury thickness closed on wound thickness
The definition for closing on 2 times of skin thickness is scar.
Administration：Each group smears corresponding medicine in modeling position scope, is administered daily 3 times, each 0.5g, gently rubs until medicine
Thing fully absorbs, successive administration 25d, visually observes and is put to death after taking pictures, aseptic operation knife cuts cicatricial tissue, locates as requested
Reason, it is standby.The high, medium and low dosage group of Chinese medicine composition cream of the embodiment of the present invention 2 gives 2.38%, 4.76% respectively,
The cream of 9.52% weight/mass percentage composition Chinese medicine composition, positive drug group give 1% asiaticoside cream.Emulsifiable paste matrix group
The blank emulsifiable paste matrix of equivalent is given, blank group and model group give normal saline.
Curative effect index：1. morphological observation：The proliferative conditions of cicatricial tissue are visually observed before administration and after administration；2. organize
The measure of middle MDA contents；3. HE is dyed, light Microscopic observation simultaneously calculates hyperplasia index (HI) and fibroblast surface density (NA).
2nd, experimental result
2.1 morphological observation
After modeling, the wound of the rabbit ear facies ventralis surface of a wound slowly starts to form a scab after wound is formed, and 4~5d crusts gradually take off
Fall, about in 10~12d, wound substantially heals, and can contact scleroma, and during 16~18d, scleroma is more obvious, and is higher than
Surface, in pale red, for hyperplasia scope not less than original edge, thickness is about the rabbit ear outside of belly to 2 times of back side skin thickness.With to
The extension of medicine time, Chinese medicine composition emulsifiable paste of the present invention is high, middle dose group scar gradually softens, and volume-diminished, tends to calm down, face
Discoloration is shallow, levels off to surrounding normal skin color, and low dosage improves unobvious.Asiaticoside emulsifiable paste group scar gradually softens, volume
Also there is a diminution, but color change unobvious.
The influence of MDA contents in 2.2 pairs of scar model rabbit ear tissues
Compared with model group, each dosage administration group MDA contents of Chinese medicine composition cream of the present invention significantly raise (P ＜
0.01 or P ＜ 0.05)；Compared with positive drug asiaticoside ointment group, Chinese medicine composition cream of the present invention is high, middle dose group MDA
Content rise has significant difference (P ＜ 0.05).Illustrate that Chinese medicine composition of the present invention can induce cell and lipid peroxidation occurs, make
Apoptosis of fibroblasts, suppresses scar growth, and high, middle dosage effect is better than asiaticoside ointment.It is shown in Table 3.
3 Chinese medicine composition of the present invention of table to MDA contents in scar model rabbit ear tissue influence (N=10)
Note：Compared with model group, * P ＜ 0.05, * * P ＜ 0.01.Compared with positive drug group,△P ＜ 0.05,△△P ＜ 0.01.
Table 4 is same.
2.3 HE dye case result
It can be seen that the obvious hyperplasia of model group dermal tissue and thickening, by a large amount of fibroblasts, collagen tissue and blood vessel group
Into fiber alignment is irregular, is distributed in tubercle or swirl shape, and epidermis still has a large amount of scar projections.Chinese medicine composition of the present invention
Blood vessel and fibroblast gradually decrease in high, medium and low dosage group cicatricial tissue, and arrangement is more neat, and scar becomes flat.Accumulated snow
Glycosides emulsifiable paste forms fibrocyte and collagenous fibres are also reduced, than sparse, in pale red.
2.3 pairs of scar model rabbit ear tissue hyperplasia indexes (HI) and the influence of fibroblast surface density (NV)
Compared with model group, each dosage administration group hyperplasia index (HI) of Chinese medicine composition cream of the present invention and into fiber finer
Born of the same parents' surface density (NV) significantly reduces (P ＜ 0.01 or P ＜ 0.05)；Compared with positive drug asiaticoside ointment group, in the present invention
Drug composition cream is high, middle dose group HI is reduced significant difference (P ＜ 0.05), and Chinese medicine composition cream of the present invention is high
Dosage group NV, which is reduced, significant difference (P ＜ 0.05).It is shown in Table 4.
Influence of 4 Chinese medicine composition of the present invention of table to scar model rabbit ear tissue hyperplasia index and fibroblast surface density
(N=10)
Example effects 3
Traditional Chinese medicine composition for treating acne clinical observation on the therapeutic effect of the present invention
1st, general information
50 patients with acne.Age, men and women was unlimited at 16~45 years old.
2nd, diagnostic criteria
2.1 Western medicine diagnostic criteria
With reference to Chinese Medical Association's version《The skin disease of clinic diagnosis guide one and venereal disease fascicle》Acne diagnostic criteria patient is young
Men and women, the seborrhea such as face and shirtfront back position is betided, there are the skin lesions such as acne, papule, fester and tubercle, tumour.
2.2 tcm diagnosis standard
With reference to People's Health Publisher's version《Modern Chinese medicine Merck Manual series skin venereal disease handbook》Acne lesions from the beginning of for
Pinhead-sized pityriasis rubra papule, or for Whiteheads, blackhead, extrudable white or faint yellow fat bolt, the shape because of infection
Into red small papule, top may occur in which small purulence lump.Feel slight itch or no conscious sympton, self-induction pain when inflammation is obvious.
3rd, exclusion standard：
1. this research traditional Chinese and western medicine diagnosis person is not met；
2. allergic constitution or to this medicine and drug ingedient allergy sufferers；
3. gestation or women breast-feeding their children；
4. the medicine for oral administration related to this disease used in the next few days, the used external used medicine person related to this disease in day；
5. merge intentionally, the cerebrovascular, liver, ' the severe primary disease such as kidney and hemopoietic system, mental patient；
6. secondary acne, acne conglobata, acne fulminans, occupational acne, drug-induced patients with acne and bad
Dead property patients with acne；
7. suffer from other face dermatosis that may influence experimental observation, such as lupus erythematosus, allergic dermatitis, psoriasis
Deng.
4th, treatment method
Face is cleaned with warm water, then is applied to the Chinese medicine composition cream of the present invention of embodiment 2 at skin lesion, all patients
Treat 1 time every night, the course for the treatment of 4 weeks, carry out follow-up within 4 months after patient cures.
5th, curative effect index：
According to pretherapy and post-treatment skin lesion number, therapeutic index, the influence of viewing test group, control group to skin lesion are calculated.
Skin lesion number × 100% before skin lesion number/treatment after skin lesion number-treatment before therapeutic index=treatment.
6th, curative effect determinate standard：
Moon reference year, Chinese Medical Association's aesthetics formulated with beauty branch beautifying skin group《The acne vulgaris order of severity point
Level and curative effect determinate standard》Carry out therapeutic evaluation.Recovery from illness skin lesion is disappeared substantially, and pain of itching disappears, and the effective skin lesion of therapeutic index is bright
Aobvious to disappear, pain of itching is obvious to be mitigated, and therapeutic index is that an effective skin lesion has been disappeared, and pain of itching mitigates, and therapeutic index is part nothing
Skin lesion is imitated to disappear seldom, or skin lesion without obvious change or aggravates, pain of itching does not mitigate or aggravated, therapeutic index.Total effective rate is
The ratio of recovery from illness, effective, effective number of cases sum and total case load.
7th, result of study：
7.1 total effectses are analyzed
In 50 patients, clinical cure 15, effective 22, effective 13, invalid 0, total effective rate 100%, control
More patient's follow-up after 4 months.No relapse, because acne easily recurs, the present invention is made of optimum feed stock, can thoroughly be cured,
Easily recurrence achieves obviously technological progress compared with prior art.Specifically it is shown in Table 5.
The total effectses of table 5 are analyzed
7.2 adverse reaction interpretations of result
Have no adverse reaction appearance in treatment group's therapeutic process.
8th, model case
1. Zhao, female, 23 years old.Face acnes were once diagnosed as endocrinopathy and cause acne, and western medicine is not cured, smeared real
The Chinese medicine composition cream of the present invention of example 2 dark red regression after 2 days is applied, is clearly better after 7 days, is fully recovered after 2 weeks, follow-up after the several months,
No relapse.
2. Xu certain, man, 20 years old, face acnes, be not cured through cosmetics and drug therapy, smear 2 Chinese medicine of the present invention of embodiment
The dark red disappearance after 1 day of composition cream, is clearly better after 3 days, fully recovers within 7 days, follow-up after the several months, no relapse.
Example effects 4
Pigmentation observation of curative effect after traditional Chinese medicine composition for treating acne of the present invention
1st, clinical data
Totally 84, be pigmentation patient after acne.Male 47, female 37,18~38 years old age, averagely 23.5 years old,
The course of disease 2.5 months~6 years, averagely 6.3 months.It is randomly divided into treatment group 40 and control group 40, two groups of sex structures, years
Age, the course of disease and coincident with severity degree of condition comparing difference are not statistically significant (P ＞ 0.05), have comparativity.
2nd, inclusive criteria
There is acne medical history, existing unilateral face acne number is less than or equal to 25, or unilateral facial papulopustule number after treatment
Less than or equal to 10.Acne lesions inflammation damages (papule, warts, tubercle, tumour etc.) place in raw hide after disappearing substantially and leaves limitation
Property pigment alteration, it is neither raised, it is also not recessed；Skin lesion at initial stage color is scarlet, can then show as kermesinus or deep brown successively
It is color, yellowish-brown, light brown, finally can voluntarily it disappear；Pigmentation size is indefinite, can be dispersed in distribution, also can be intensive in blocks, typically
No conscious sympton.Patient willingness treats and further consultation on time, signs informed consent form.
3rd, exclusion standard
The acne pigmentation of other used decolorising agents in 2 weeks；Pigment caused by Other diseases (such as freckle, chloasma etc.)
Calmness, in the gestational period or nursing period, with serious systemic disease, skin ulceration or sensitive, it is impossible to adhere to treatment and
Compliance is poor.
4th, treatment method
Treatment group：Cleaning face after, with ion atomizer spray 10min, pore open after, by the present invention of embodiment 4
Drug composition plastics is applied to face, treats every night once, totally 8 weeks.
Control group：Sprayed 10min with ion atomizer after same cleaning face, after pore opens, using 0.1% vitamin A acid
Emulsifiable paste smears face, and clean, the same treatment group of method is cleaned after retaining 20min.
During treatment, disabling may have the medicine of decolouring or whitening function, avoid pungent stimulation, greasy and high sugar content food
Thing, more veterinary antibiotics of the food rich in vitamin, drinks more water, ensures sleep, less with excitant cosmetics, avoids directly exposure sun
Under light.
5th, observation index
Therapeutic evaluation is carried out after treating 8 weeks, skin lesion regression situation and pigmented regression situation are observed, before record treatment
The area and statistics of acne lesions regression situation and pigmentation spot afterwards.
6th, curative effect index
Recovery from illness：Visually observe color spot area to disappear more than or equal to 90%, pigmentation disappears substantially.It is effective：Visually observe
Color spot area regression 60%~89%, pigmentation is substantially thin out.Take a turn for the better：Color spot area regression 30%~59% is visually observed,
Pigmentation is thin out.It is invalid：Visually observe color spot area to disappear less than or equal to 30%, pigmentation change unobvious.
Enumeration data is examined using T, and P ＜ 0.05 are that difference is statistically significant.
7th, treatment results
Two groups of curative effects are relatively shown in Table 6.
6 two groups of curative effects of table compare
Note：Compared with control group, * P ＜ 0.05
8th, adverse reaction
The first medication rear face for the treatment of group is died away after occurring micro- red 1,1~2 day during treatment, no fash and other
Discomfort, do not influence to treat, do not occur stimulate the reaction again when treating thereafter.There is face after control group treatment for the first time and dry furfur
6, alleviate after anti symptom treatment, remain to adhere to completing treatment.
Described above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, under the premise without departing from the principles of the invention, some improvements and modifications can also be made, these improvements and modifications also should
It is considered as protection scope of the present invention.
Claims (10)
1. a kind of anti acne of traditional Chinese medicine composition, it is characterised in that it is made up of the raw material of following portions by weight：
It is 15~40 parts of Gotu Kola P.E, 10~30 parts of Baical Skullcap root P.E, 5~20 parts of vitamin E, 5~20 parts of caryophyllus oil, sweet
Careless 5~10 parts of extract, 2~8 parts of shrubby sophora extract, 1~5 part of hydrolyzed pearl, 0.5~3 part of borneol.
2. anti acne of traditional Chinese medicine composition according to claim 1, it is characterised in that it is by the raw material system of following portions by weight
Into：
40 parts of Gotu Kola P.E, 10 parts of Baical Skullcap root P.E, 20 parts of vitamin E, 20 parts of caryophyllus oil, 5 parts of licorice, hardship
2 parts of conopsea extraction, 5 parts of hydrolyzed pearl, 0.5 part of borneol.
3. anti acne of traditional Chinese medicine composition according to claim 1, it is characterised in that it is by the raw material system of following portions by weight
Into：
15 parts of Gotu Kola P.E, 10 parts of Baical Skullcap root P.E, 20 parts of vitamin E, 5 parts of caryophyllus oil, licorice 10, kuh-seng
8 parts of extract, 1 part of hydrolyzed pearl, 3 parts of borneol.
4. anti acne of traditional Chinese medicine composition according to claim 1, it is characterised in that it is by the raw material system of following portions by weight
Into：
30 parts of Gotu Kola P.E, 30 parts of Baical Skullcap root P.E, 10 parts of vitamin E, 15 parts of caryophyllus oil, 8 parts of licorice, hardship
6 parts of conopsea extraction, 4 parts of hydrolyzed pearl, 2 parts of borneol.
5. anti acne of traditional Chinese medicine composition according to claim 1, it is characterised in that it is by the raw material system of following portions by weight
Into：
25 parts of Gotu Kola P.E, 20 parts of Baical Skullcap root P.E, 10 parts of vitamin E, 10 parts of caryophyllus oil, licorice 7, kuh-seng
5 parts of extract, 2 parts of hydrolyzed pearl, 1 part of borneol.
6. anti acne of traditional Chinese medicine composition according to claims 1 to 5, it is characterised in that the Gotu Kola P.E contains accumulated snow
Careless glycosides and madecassoside, which amount to, is no less than 60%；Baical Skullcap root P.E must not be less than 85% containing scutelloside；Caryophyllus oil contains cloves
Phenol is no less than 80%；Licorice is no less than 70% containing dipotassium glycyrrhizinate；Shrubby sophora extract is no less than containing oxymatrine
90%.
7. anti acne of traditional Chinese medicine composition according to claim 6, it is characterised in that：The preparation method of the Gotu Kola P.E
For：Centella is taken, with the 75% ethanol heating and refluxing extraction 2 times of 10 times of volumes of medicinal material weight, 1 hour every time, merging filtrate,
Filtrate recycling ethanol, it is concentrated into equivalent to raw medicinal herbs 1g/mL, adds 4 times of amount water, stirring while adding, refrigerated overnight, centrifuge, centrifugation
Liquid is 2.0 with 2mol/L salt acid for adjusting pH value, refrigerated overnight, centrifugation, extracting centrifugal liquid, upper macroporous resin column, is first washed with water
Resin column, then with the ethanol of volumetric concentration 30% to wash resin column, finally with the ethanol elution of volumetric concentration 50%, collect 50% second
Alcohol eluen；Ethanol is recovered under reduced pressure to without alcohol taste in eluent, dry, pulverize and produces；
The preparation method of the Baical Skullcap root P.E is：Radix scutellariae is taken, the decocting of dosing material 12 times of volumes of weight is boiled 1 to 3 time, is merged and is decocted
Liquid, concentration, with salt acid for adjusting pH value to 1.0~2.0,80 DEG C of insulations, stand, filtration, sediment adds suitable quantity of water to stir evenly, uses hydrogen-oxygen
Change sodium solution and adjust pH value to 7.0, add ethanol to be stirred to dissolve, filter, filtrate is with salt acid for adjusting pH value to 1.0~2.0,60 DEG C
Insulation, stand, filtration, precipitation is washed till pH value to 7.0 with water and ethanol successively, waves most ethanol, concentrates, dries, produce；
The preparation method of caryophyllus oil is：The dry flower of plant clove of myrtaceae is taken, through steam distillation, obtains volatile oil；
The preparation method of licorice is：Extracting liquorice, run through, cut into slices, add 70 DEG C of extractions of water three times, 2 hours every time, merging carried
Liquid is taken, standing overnight makes precipitation, takes supernatant, and dense HCl is adjusted to pH value to 3.0, stood, precipitation filtering, precipitation is dissolved with water, added
Enter potassium hydroxide solution, 50-70 DEG C of reaction 3-5 hour；Concentration, dry, produce；
The preparation method of shrubby sophora extract is：Take the ethanol solution of kuh-seng volumetric concentration 80% (ammonification water in 1000ml ethanol
20ml) extract 2 times, 1 hour every time, filtrate merged, and is concentrated into no alcohol taste, and then plus 3 times of amount water dilute, and add hydrochloric acid to adjust pH extremely
3.0, stand, filtering, filtrate is extracted 3 times with ether, and water layer adjusts PH to 11 with ammoniacal liquor, is then extracted with ethyl acetate 3 times, is closed
And acetic acid ethyl acetate extract, it is recovered under reduced pressure, residue is dissolved with ethanol, adds hydrogen peroxide, and reaction is complete, concentrates, and dries, dried object
Dissolved by heating with hot ether, recrystallize and produce；
The preparation method of hydrolyzed pearl is：Take pearl is ground fine powder is made, acid adding relaxes hydrolysis, deacidification, concentration, dried, powder
It is broken, produce.
8. a kind of Chinese medicine preparation of anti-acne, it is characterised in that by the raw material described in any one of claim 1 to 6 and pharmaceutically
External preparation is made in acceptable auxiliary material.
9. the Chinese medicine preparation of anti-acne according to claim 8, it is characterised in that the formulation of described preparation is ointment
Agent, cream, gel, liniment, paint, plastics, tincture, emplastrum or Babu plaster.
10. any described anti acne of traditional Chinese medicine composition of claim 1~6 is in medicine or/and cosmetics for anti-acne is prepared
Application.
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| CN108403621A (en) * | 2018-05-07 | 2018-08-17 | 广州度普生物科技有限公司 | A kind of antibacterial blemish clearing gel of multiple target point and preparation method thereof |
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| CN107929134A (en) * | 2017-12-08 | 2018-04-20 | 广东迪美新材料科技有限公司 | A kind of kuh-seng repairs acne removing agent and its preparation method and application |
| CN108210433A (en) * | 2018-01-17 | 2018-06-29 | 北京明弘科贸有限责任公司 | Cardamom skin care compositions and its application with oil-control and/or acne-removing |
| CN108403621A (en) * | 2018-05-07 | 2018-08-17 | 广州度普生物科技有限公司 | A kind of antibacterial blemish clearing gel of multiple target point and preparation method thereof |
| CN109010245A (en) * | 2018-09-13 | 2018-12-18 | 广东丸美生物技术股份有限公司 | Anti-acne preparations |
| CN109730946A (en) * | 2019-03-09 | 2019-05-10 | 广州市壹美和生物科技有限公司 | Active acne-eliminating liquid and lotion, Essence and face cream containing active acne-eliminating liquid |
| CN110075043A (en) * | 2019-05-23 | 2019-08-02 | 湖北省吉美化妆品有限公司 | Have effects that the plant extract composition and its application in external application skin care formulation that anti-inflammatory anti-acne is repaired |
| CN115252665A (en) * | 2022-07-26 | 2022-11-01 | 宁波绿之健药业有限公司 | Preparation method and application of centella asiatica extract |
| CN117064822A (en) * | 2023-10-16 | 2023-11-17 | 广州市中通生化制品有限公司 | Plant acne-removing composition, plant acne-removing patch and preparation method of plant acne-removing composition |
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