CN1157195C - Soft capsule of superfine compound pearl powder and its preparing process - Google Patents

Abstract

The present invention relates to a superfine compound pearl powder soft capsule and a preparation method. The superfine compound pearl powder soft capsule disclosed by the present invention is composed of 30% to 60% of superfine pearl powder, 5% to 10% of vitamin E, 0.5% to 1.5% of excipient and 30% to 60% of base materials. The present invention applies the superfine pulverization technology to the traditional Chinese medicine field, and combines the superfine pearl powder and the vitamin E. Therefore, the soft capsule has the health-care function of the pearl powder and the vitamin E, and has the efficacy of strongly removing oxygen free radicals, enhancing immunity, arresting convulsion, tranquilizing, improving sleep, supplementing calcium, removing speckles and beautifying. The present invention has favorable social and economic benefits for satisfying people to reinforce own health and health care and enhancing quality of life.

Description

A kind of soft capsule of superfine compound pearl powder and preparation method

The present invention relates to Chinese medicine preparation and preparation method, be specifically related to a kind of soft capsule of superfine compound pearl powder and preparation method.

Product processing for Margarita generally has physics, chemistry and biological method.Water soluble Margarita ultrafine powder is by acid and alkali hydrolysis, makes calcium carbonate in the Margarita become the calcium salt of solubility, and Proteolytic enzyme wherein or become aminoacid by the protease effect is so that the direct absorption of human body.But through after the hydrolysis, contained many effective ingredient in the natural peral (as activated calcium etc.) all have loss in various degree.The health care drug effect of Margarita mainly comes from its mass action, comprise above plurality of active ingredients and comprehensive effect thereof, and some active component only can keep just in former Margarita or through special handling.

The objective of the invention is to provide a kind of novel Margarita ultrafine powder and the soft capsule of vitamin E compatibility, make its shortcoming that overcomes prior art more help absorption of human body, the fortification effect that have stronger removing oxygen-derived free radicals, improves immunity.

Soft capsule of superfine compound pearl powder disclosed by the invention is made up of 30%-60% Margarita ultrafine powder, 5%-10% vitamin E, 0.5%-1.5% excipient and 30%-60% substrate.

Margarita ultrafine powder of the present invention is meant with comminution by gas stream and makes 98% powder diameter less than 1200 purpose Margarita powder.

Excipient of the present invention is meant Cera Flava, paraffin etc.

Substrate of the present invention is meant soybean oil, olive oil, almond oil, Radix Oenotherae erythrosepalae wet goods vegetable oil.

Another object of the present invention is the preparation method that will disclose above-mentioned soft capsule of superfine compound pearl powder.

Soft capsule of superfine compound pearl powder disclosed by the invention makes by following step:

(1) Margarita ultrafine powder preparation

Use ball mill to pulverize earlier after the selected and Margarita drying of cleaning, sieve, choose the following Margarita powder of 100 orders then and carry out comminution by gas stream to 1200 order, microwave sterilizating is standby;

(2) content allotment

0.5%-1.5% excipient, 30%-60% substrate soybean oil are heated to about 50 ℃, stir and treat its complete fusion, promptly make Cera Flava oil; 30%-60% Margarita ultrafine powder and 5%-10% vitamin E are added in the Cera Flava oil, stir evenly; Sieve with the colloid mill waterproof pulverization, it is standby to make oil suspension;

(3) soft capsule preparation

Get 2 parts of gelatin adding suitable quantity of water and make it imbibition, 1 part of glycerol heating back is added expansible gelatin, be heated with stirring to fusion; The filtration of shell glue is bled, remove part moisture content and foam, use revolving die formula soft capsule maker, deployed content is pressed into the shell film, be wrapped in and wherein form soft capsule.The greasy dirt of flush away capsule surface, placing temperature is 25-30 ℃, relative humidity is dry in the drying room of 20%-25%, promptly makes soft capsule of superfine compound pearl powder.

Contain a large amount of calcium salts and aminoacid in the chemical constituent of Margarita.With the pinctada fucata is example, wherein contains 16 kinds of inorganic elementss, and calcium carbonate is main, and inferior is silicon, sodium, magnesium compound.Contain 16 seed amino acids in the Margarita keratin, alanine, glycine content are higher, and inferior is aspartic acid, leucine and arginine.Wherein contained taurine is the main effective ingredient of treatment anovulatory dysfunctional uterine hemorrhage and chronic hepatitis.The pearl quality in the different places of production has certain difference, and its amino acid content is at 2.8%-4.1%.Since Margarita contained calcareous with aminoacid form with human body in quite similar, therefore this biologically actived calcium is absorbed by the body than inorganic calcium salt is easier.

Except replenishing the calcium, the effect of Margarita powder also shows following several respects:

(1) delaying senility function is edible for silkworm with Margarita powder medicinal liquid immersion Folium Mori, and the silkworm larva phase is significantly shortened, and the adult stage prolongs by a relatively large margin.Feed white mice with the Margarita powder mixed feed, make mice average life prolong 21.6%.There are substantial connection at lipofuscin content and age in the histiocyte, are reliably old and feeble and tangible sign.To mouse peritoneal injection Margarita powder suspension, the lipofuscin content of cardiac muscle and cerebral tissue is obviously reduced.

Xiyuan Hospital, Chinese Medicine Academy of China has carried out clinical experiment to the timid speckle effect of the beauty treatment of Margarita powder.30 routine women's chloasma experimenters through medical fitness took Margarita powder continuous 30 days, as a result the chloasma area 21.38 ± 28.89mm that on average descends ², color obviously shoals, produce effects person's 6 examples, and responder's 16 examples, total effective rate reaches 73.33%.Routine blood test, routine urinalysis and blood biochemistry index are no abnormal before and after edible, and the healthy nothing of eater is obviously influenced.The proof Margarita powder has the timid speckle effect of tangible skin care.

(2) antioxidation more and more studies show that, free radical participates in many physiology and pathological process.Some biochemical reaction of free yl induction plays an important role in the generation of biological decay and evolution.When body was in the normal physiological state, free radical constantly produced, and also constantly removed.SOD (superoxide dismutase) is an important substance of removing free radical in the body, and it reduces along with the aging of human body.Margarita powder can significantly improve old Mus SOD activity, and improves the activity of GSH-Px (glutathion peroxidase), and the effect of strengthening removing free radical is arranged.The total porphyrin composition (FPC) that extracts in the Margarita can suppress radical reaction, removes superoxide anion in the body.

Through Shanghai City preventive medicine academy Margarita powder is carried out health care and learn evaluation, the result proves that Margarita powder can obviously reduce lipid peroxide catabolite MDA content in the blood, increases the vigor of superoxide dismutase in the blood.Sleeping number of animals and the sleep incidence rate of the inductive mice of dosage pentobarbital sodium under the territory can be increased, the length of one's sleep of the inductive mice of dosage pentobarbital sodium on the territory can be prolonged.Illustrate that Margarita powder has antioxidation and improves the sleep effect.

(3) to the Immune Effects pearl oral liquid mice is significantly strengthened to the lymphocyte transfer reaction that PHA (phytohemagglutinin) stimulates, improve the level of mice serum IgG, the mouse peritoneal phagocytic function is obviously strengthened, obviously strengthen cellular immunization and humoral immunization.This effect may be relevant with its contained rich in amino acid composition.

(4) the blood pressure lowering curative effect is taken pearl powder capsule to 75 routine primary hypertension patients and is observed antihypertensive effect after 1 month, 85.3% reaches and improves symptom: make receipts, relaxing to press extremely significantly descends, sleep quality improves behind the most of patients medicine, headache, dizzyly obviously alleviate, the effective percentage of cardiopalmus, insomnia is reached 90.4% and 86.4% respectively.

The same Disodium EDTA of vitamin E.Although the vitamin E concentration on the cell membrane is very low, it is still first-line fat-soluble antioxidant.It can capture and remove free radical soon, to prevent that the polyvalent unsaturated fatty acid of phospholipid is subjected to the attack of free radical and produces lipid peroxidation on the film.Lipid peroxidation can make fatty acid fracture shortening on the film, loses degreasant fluid properties and normal function, and cytotoxic peroxide can cause cell death.Vitamin E can influence leukocytic chemotaxis, random migration and activate the phagocytic capacity.Animal experiment shows that vitamin E can obviously resist the inductive quantity of leucocyte decline of immunosuppressant CTX and function reduces, and the inductive immunologic hypofunction state of antagonism CTX increases the weight of thymus and spleen; IgG content increases in the serum; The T lymphopoiesis is strengthened; INF-γ content significantly improves in the blood.Experimental results show that vitamin E has regulating action to immunologic function.

Margarita ultrafine powder adopts the physical method of comminution by gas stream, keep its active component to greatest extent, and decomposed, absorb and utilize by human body apace easily with its superfine advantage (98% powder diameter is less than 10 microns, and general ball mill pulverizing particle diameter is greater than 75 microns).And vitamin E is the nutrition that human body can not lack.By advanced person's production technology,, can bring into play the two complementary effect scientifically with the two comprehensive utilization.Than pure Margarita powder, the fortification effect that product of the present invention has stronger removing oxygen-derived free radicals, improves immunity; Compare with the vitamin E of single-prescription, this product has increased arresting convulsion again and has calmed the nerves, improves sleep, replenishes the calcium and effect that timid speckle is improved looks.Soft capsule of superfine compound pearl powder of the present invention has had both the health care of Margarita powder and vitamin E, and the untoward reaction that each composition does not have interfering with each other and lowers effect in the compound recipe, so this prescription has its special advantages.Adopt soft capsule dosage form, avoided the discomfort sensation of medicine immediate access, be convenient to consumer more and take.

Soft capsule of superfine compound pearl powder of the present invention is applied to the field of Chinese medicines with superfine technique, and with Margarita ultrafine powder and vitamin E compatibility, the health care that has had both Margarita powder and vitamin E has stronger removing oxygen-derived free radicals, improves immunity, sleep is calmed the nerves, improved in arresting convulsion, replenish the calcium and effect that timid speckle is improved looks.Strengthen self-health care to satisfying people, improving the quality of living has good society and economic benefit.

Embodiment 1

Prescription

Margarita ultrafine powder 460g

Vitamin E 77g

Cera Flava 13g

Soybean oil 450g

(1) Margarita ultrafine powder preparation

Use ball mill to pulverize earlier after the selected and Margarita drying of cleaning, sieve, choose the following Margarita powder of 100 orders then and carry out comminution by gas stream extremely 1200 orders, microwave sterilizating is standby;

(2) content allotment

13g Cera Flava, 450g soybean oil are heated to about 50 ℃, stir and treat its complete fusion, promptly make Cera Flava oil; 460g Margarita ultrafine powder and 77g vitamin E are added in the Cera Flava oil, stir evenly; Sieve with the colloid mill waterproof pulverization, it is standby to make oil suspension;

(3) soft capsule preparation

Get 300g gelatin adding suitable quantity of water and make it imbibition, 150g glycerol heating back is added expansible gelatin, be heated with stirring to fusion; The filtration of shell glue is bled, remove part moisture content and foam, use revolving die formula soft capsule maker, deployed content is pressed into the shell film, be wrapped in and wherein form soft capsule.The greasy dirt of flush away capsule surface, placing temperature is 25-30 ℃, relative humidity is dry in the drying room of 20%-25%, promptly makes soft capsule of superfine compound pearl powder.Every capsules contains content 0.65g

Embodiment 2

Prescription

Margarita ultrafine powder 500g

Vitamin E 50g

Cera Flava 6g

Radix Oenotherae erythrosepalae oil 444g

Make soft capsule of superfine compound pearl powder with embodiment 1 method, every capsules contains content 0.5g.

Embodiment 3

Prescription

Margarita ultrafine powder 560g

Vitamin E 80g

Paraffin 10g

Soybean oil 350g

Make soft capsule of superfine compound pearl powder with embodiment 1 method, every capsules contains content 1.0g.

Claims (5)

1, a kind of soft capsule of superfine compound pearl powder is characterized in that this ultra-fine pearl powder capsule is made up of 30%-60% Margarita ultrafine powder, 5%-10% vitamin E, 0.5%-1.5% excipient and 30%-60% substrate.

2, a kind of soft capsule of superfine compound pearl powder as claimed in claim 1 is characterized in that wherein said Margarita ultrafine powder is that 98% powder diameter is less than 1200 purpose Margarita powder.

3, a kind of soft capsule of superfine compound pearl powder as claimed in claim 1 is characterized in that wherein said excipient is Cera Flava and paraffin.

4, a kind of soft capsule of superfine compound pearl powder as claimed in claim 1 is characterized in that wherein said substrate is vegetable oil.

5, a kind of preparation method of soft capsule of superfine compound pearl powder as claimed in claim 1 is characterized in that this soft capsule is to be made by following step:

(1) Margarita ultrafine powder preparation

Use ball mill to pulverize earlier after the selected and Margarita drying of cleaning, sieve, choose the following Margarita powder of 100 orders then and carry out comminution by gas stream to 1200 order, microwave sterilizating is standby;

(2) content allotment

0.5%-1.5% excipient, 30%-60% substrate soybean oil are heated to about 50 ℃, stir and treat its complete fusion, promptly make Cera Flava oil; 30%-60% Margarita ultrafine powder and 5%-10% vitamin E are added in the Cera Flava oil, stir evenly; Sieve with the colloid mill waterproof pulverization, it is standby to make oil suspension;

(3) soft capsule preparation

Get 2 parts of gelatin adding suitable quantity of water and make it imbibition, 1 part of glycerol heating back is added expansible gelatin, be heated with stirring to fusion; The filtration of shell glue is bled, remove part moisture content and foam, use revolving die formula soft capsule maker, deployed content is pressed into the shell film, be wrapped in and wherein form soft capsule.The greasy dirt of flush away capsule surface, placing temperature is 25-30 ℃, relative humidity is dry in the drying room of 20%-25%, promptly makes soft capsule of superfine compound pearl powder.