CN1294904C - Method for preventing content adhesion in soft capsule with high solid content - Google Patents
Method for preventing content adhesion in soft capsule with high solid content Download PDFInfo
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- CN1294904C CN1294904C CNB2005100183732A CN200510018373A CN1294904C CN 1294904 C CN1294904 C CN 1294904C CN B2005100183732 A CNB2005100183732 A CN B2005100183732A CN 200510018373 A CN200510018373 A CN 200510018373A CN 1294904 C CN1294904 C CN 1294904C
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Abstract
The present invention relates to a method for preventing content adhesion in a soft capsule with high dried solids. The present invention is characterized in that the content of the soft capsule with high dried solids is added with decanoyl/octanoyl-glyceride accounting for 4% to 45% of the total weight of the content of the soft capsule with high dried solids and the high dried solids are pearl powder or ginseng powder. Through the addition of the decanoyl/octanoyl-glyceride belonging to the intermediate carbon chain glyceride in the content of the soft capsule with high dried solids, the present invention can reduce the adhesion capability of the high dried solids, can obviously improve the fluidity of the materials, can greatly improve the content of the high dried solids, can make the preparation of the materials and pill pressing work easy, and has low cost in soft capsule preparation. The present invention is applied to a compound pearl soft capsule so that the content of the pearl powder can reach more than 60%, the volume of the soft capsule is greatly reduced, and various effects of the pearls can be conveniently exerted. The present invention is applied to a ginseng powder soft capsule so that the content of ginseng can reach more than 55%.
Description
Technical field
The present invention relates to the viscid method of content that a kind of solution contains high level cadre's dry solid material soft capsule.
Background technology
The soft capsule preparation worker wishes soft gelatin capsule is done as far as possible little, the user is swallowed as far as possible less and material that application target is irrelevant, and make swallow, transport, store more convenient.High dry solids content is (as Margarita powder) more for a long time, usually can make because of the viscous of material to make to meet difficulty.The approach that solves can be crushed to material enough fineness usually; Screen suitable suspending agent, reduce the consumption of suspending agent; Discharge the bubble that process for preparation is brought into; When above-mentioned way is invalid, have to strengthen the consumption of diluent, the content composition of soft capsule is divided into a plurality of unit, increase the workload of making like this, strengthen and manufacture cost, and make troubles to the user.
Herbal pharmaceutical one factory of Shanghai medical material company proposes the patent of soft capsule of superfine compound pearl powder; number of patent application 00125898.2; the inventor considers to run in the pearl powder soft capsule making and is difficult to overcome viscid difficulty that the content of its claim protection Margarita ultrafine powder is 30%～60%.We attempt breaking through 60% the upper limit, meet difficulty, and the ultra-fine pearl powder content can not be high again.
Be generally used for the general vegetable oil of the diluent that soft capsule makes, mainly contain long-chain fatty acid glyceride (Long ChainTriglycerides, LCT).And decanoyl/octanoyl glycerides system is by the mixture that contains the glyceride that 8 and 10 carbon atom saturated monocarboxylic acids are formed, and (Medium Chain Triglycerides, MCT), it is MCT for commercial abbreviation to belong to middle chain triglyceride.Its carbochain is shorter, and the general vegetable oil of its viscosity ratio is at half above.Its odorless, colourless; Ductility, lubricity are also good than other plant oil; Various lipids, fatsoluble vitamin there is good intermiscibility; Decanoyl/octanoyl glycerides all has good stability to high temperature and low temperature, the stability of oxidation is about 16 times of soybean oil.
The sixties in 20th century, medical circle began one's study MCT to the digesting and assimilating of human body, physiological property, to the adaptability of various diseases.Studies show that the infiltration rate of MCT in intestinal is faster than general oils and fats.Be hydrolyzed to fatty acid and glycerol rapidly at intestinal, be decomposed into CO2 and H2O through portal venous circulation rapidly to liver, provide heat to body, metabolic speed is 8-10 times of LCT.Metabolism in vivo is also different with long-chain fatty acid (LCT), and it does not need to rely on the L-carnitine, does not form new fat in the body inner accumulated.Therefore, think that MCT can be used as the supplementary of rapid makeup energy; Help fat-reducing; Control too high cholesterol.Be applied to middle carbon chain fatty acid glyceride clinical successively.
A large amount of studies show that decanoyl/octanoyl glycerides is harmless, the oral LD of rat
50＞36ml/kg, lumbar injection＞24ml/kg; Intramuscular injection, skin and eye irritation test, the reproduction test of 2 generations, tertogenicity test, all negative.Confirmed as the GRAS material by U.S. FDA, also listed the use sanitary standard in China, Food Additives Used in China divides apoplexy due to endogenous wind to classify 10.018 as.In food additive, can be used as emulsifying agent and use, be used for the making of emulsifying essence, cosmetics, beverage, confection, chocolate, milk powder.But not seeing as yet so far has MCT to be used for the record that high level cadre's dry solid material soft capsule is made.
Summary of the invention
The object of the present invention is to provide a kind of solution to contain the viscid method of content of high level cadre's dry solid material soft capsule, this method can make the high dry solids content in the soft capsule improve greatly; The soft capsule cost of manufacture is reduced.
To achieve these goals, technical scheme of the present invention is: a kind of solution contains the viscid method of content of high level cadre's dry solid material soft capsule, it is characterized in that adding decanoyl/octanoyl glycerides in the content that contains high level cadre's dry solid material soft capsule, the addition of decanoyl/octanoyl glycerides accounts for 4%～45% of the content gross weight that contains high level cadre's dry solid material soft capsule.
When high dry substance was Margarita powder, the addition of decanoyl/octanoyl glycerides accounted for 4%～39% of the content gross weight that contains high level cadre's dry solid material soft capsule.
Described content is the set of all compositions in the soft capsule.
The present invention adopts and add the decanoyl/octanoyl glycerides that belongs to middle chain triglyceride in the content that contains high level cadre's dry solid material soft capsule, can reduce the viscosity of high dry substance, obviously improves the flowability of material, and its high dry solids content improves greatly; And the preparation of material and pelleting work are become easily, the soft capsule cost of manufacture reduces.The present invention is applied to make in the Compound Zhenzhu soft capsule Margarita powder content to reach more than 60%, has dwindled the volume of this soft capsule greatly, is convenient to bring into play the various effects of Margarita.The present invention is applied to make in Radix Ginseng powder's soft capsule Radix Ginseng content to reach more than 55%.
The specific embodiment
What enumerate below is to realize optimal way of the present invention.Adopt the higher limit or the lower limit of the addition of decanoyl/octanoyl glycerides can both realize purpose of the present invention, embodiment just differs and one enumerates.
Embodiment 1: a kind of solution contains the viscid method of content of high level cadre's dry solid material soft capsule, adds decanoyl/octanoyl glycerides in the content that contains high level cadre's dry solid material soft capsule, and containing high level cadre's dry solid material soft capsule is the Compound Zhenzhu powder capsule.
The Compound Zhenzhu powder capsule, it is made up of Margarita powder, vitamin E, soybean salad oil, decanoyl/octanoyl glycerides and Cera Flava, and the shared weight of each component is:
Margarita powder (the emerald green more pharmaceutcal corporation, Ltd of Zhejiang Zhuji City) 3000g,
Vitamin E (BASF AG) 200g,
Soybean salad oil, (commercially available, Wuhan Zhong Chang vegetable oil company limited) 1090g,
Decanoyl/octanoyl glycerides (import) 570g,
Cera Flava (Dongguang County, Hebei drug packing material factory) 38g.
The preparation method of above-mentioned Compound Zhenzhu powder capsule, comprise the steps: 1). be by weight: Margarita powder 3000g, vitamin E 200g, soybean salad oil 1090g, decanoyl/octanoyl glycerides 570g, Cera Flava 38g, choose Margarita powder, vitamin E, soybean salad oil, decanoyl/octanoyl glycerides, Cera Flava; 2). get Margarita powder, add vitamin E and make compound; 3). get decanoyl/octanoyl glycerides, soybean salad oil, Cera Flava, heat fused is made oily wax mixture; 4). oily wax mixture is added in the compound, stir, cross colloid mill or homogenizer, vacuum outgas then; 5). by existing revolving die formula soft capsule processing technology, make 10000 soft capsules, every contains Margarita powder 0.3g, vitamin E 20mg, Margarita powder content reaches 61.25%, and vitamin E accounts for 4.1%.
Embodiment 2: a kind of solution contains the viscid method of content of high level cadre's dry solid material soft capsule, adds decanoyl/octanoyl glycerides in the content that contains high level cadre's dry solid material soft capsule, and containing high level cadre's dry solid material soft capsule is the Compound Zhenzhu powder capsule.
The Compound Zhenzhu powder capsule, it is made up of Margarita powder, vitamin E, decanoyl/octanoyl glycerides and Cera Flava, and the shared weight of each component is:
Margarita powder (the emerald green more pharmaceutcal corporation, Ltd of Zhejiang Zhuji City) 3000g,
Vitamin E (BASF AG) 200g,
Decanoyl/octanoyl glycerides (import) 1395g,
Cera Flava (Dongguang County, Hebei drug packing material factory) 20g.
The preparation method of above-mentioned Compound Zhenzhu powder capsule comprises the steps: 1). be by weight: Margarita powder 3000g, vitamin E 200g, decanoyl/octanoyl glycerides 1395g, Cera Flava 20g, choose Margarita powder, vitamin E, decanoyl/octanoyl glycerides, Cera Flava; 2). get vitamin E, decanoyl/octanoyl glycerides, Cera Flava, heat fused is made oily wax mixture; 3). oily wax mixture is added in the Margarita powder, stir, cross colloid mill or homogenizer, vacuum outgas then; 4). by existing revolving die formula soft capsule processing technology, adopt No. 5 mould, make 10000 soft capsules, the tolerant average heavy 0.4615g of every intragranular contains Margarita powder 0.3g, vitamin E 20mg, Margarita powder accounts for 65%, and vitamin E accounts for 4.3%.
Embodiment 3: a kind of solution contains the viscid method of content of high level cadre's dry solid material soft capsule, adds decanoyl/octanoyl glycerides in the content that contains high level cadre's dry solid material soft capsule, and containing high level cadre's dry solid material soft capsule is pearl powder soft capsule.
Pearl powder soft capsule, it is made up of Margarita powder, olive oil, decanoyl/octanoyl glycerides and Cera Flava, and the shared weight of each component is:
Margarita powder (the emerald green more pharmaceutcal corporation, Ltd of Zhejiang Zhuji City) 3000g,
Olive oil (import) 466g,
Decanoyl/octanoyl glycerides (import) 1106g,
Cera Flava (Dongguang County, Hebei drug packing material factory) 8g.
The preparation method of above-mentioned pearl powder soft capsule comprises the steps: 1). be by weight: Margarita powder 3000g, olive oil 240g, decanoyl/octanoyl glycerides 1106g, Cera Flava 8g, choose Margarita powder, olive oil, decanoyl/octanoyl glycerides, Cera Flava; 2). olive oil, decanoyl/octanoyl glycerides, Cera Flava, heat fused is made oily wax mixture; 3). oily wax mixture is added in the Margarita powder, stir, cross colloid mill, vacuum outgas then; 4). by existing revolving die formula soft capsule processing technology, adopt No. 6 mould, make 10000 soft capsules.Average every soft capsule content is 0.458g, Margarita powder content 0.3g, and Margarita powder content reaches 65.5%.
Embodiment 4: a kind of solution contains the viscid method of content of high level cadre's dry solid material soft capsule, adds decanoyl/octanoyl glycerides in the content that contains high level cadre's dry solid material soft capsule, and containing and being higher than dry solid material soft capsule is the Radix Ginseng powder capsule.
Radix Ginseng powder's soft capsule, it is made up of Radix Ginseng, soybean salad oil, decanoyl/octanoyl glycerides and Cera Flava, and the shared weight of each component is:
Radix Ginseng (commercially available) 5000g,
Soybean salad oil (commercially available, Wuhan Zhong Chang vegetable oil company) 703g,
Decanoyl/octanoyl glycerides (import) 3306g,
Cera Flava (Dongguang County, Hebei drug packing material factory) 12g.
Above-mentioned Radix Ginseng preparation of soft capsule method comprises the steps: 1). be by weight: Radix Ginseng 5000g, soybean salad oil 703g, decanoyl/octanoyl glycerides 3306g, Cera Flava 12g, choose Radix Ginseng, soybean salad oil, decanoyl/octanoyl glycerides, Cera Flava; 2). Radix Ginseng is pulverized, and sieve is got 100 orders with thin powder; 3). get soybean salad oil, decanoyl/octanoyl glycerides, Cera Flava heat fused, make oily wax mixture; 4). oily wax mixed liquor is added among the Radix Ginseng powder, stir, make compound; 5). compound is through colloid mill, vacuum outgas then; 6). by existing revolving die formula soft capsule processing technology, adopt No. 14 mould, make 10000 soft capsules.Every soft capsule contains Radix Ginseng powder 500mg, and Radix Ginseng powder's content reaches 55.4%.
Claims (3)
1. viscid method of content that solution contains high level cadre's dry solid material soft capsule, it is characterized in that adding decanoyl/octanoyl glycerides in the content that contains high level cadre's dry solid material soft capsule, the addition of decanoyl/octanoyl glycerides accounts for 4%～45% of the content gross weight that contains high level cadre's dry solid material soft capsule.
2. the viscid method of content that a kind of solution according to claim 1 contains high level cadre's dry solid material soft capsule is characterized in that: described high dry substance is Margarita powder or Radix Ginseng powder.
3. the viscid method of content that a kind of solution according to claim 1 contains high level cadre's dry solid material soft capsule, it is characterized in that: when described high dry substance was Margarita powder, the addition of decanoyl/octanoyl glycerides accounted for 4%～39% of the content gross weight that contains high level cadre's dry solid material soft capsule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100183732A CN1294904C (en) | 2005-03-14 | 2005-03-14 | Method for preventing content adhesion in soft capsule with high solid content |
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| CNB2005100183732A CN1294904C (en) | 2005-03-14 | 2005-03-14 | Method for preventing content adhesion in soft capsule with high solid content |
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| CN1682698A CN1682698A (en) | 2005-10-19 |
| CN1294904C true CN1294904C (en) | 2007-01-17 |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1350850A (en) * | 2000-10-31 | 2002-05-29 | 上海市药材有限公司中药制药一厂 | Soft capsule of superfine compound pearl powder and its preparing process |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1350850A (en) * | 2000-10-31 | 2002-05-29 | 上海市药材有限公司中药制药一厂 | Soft capsule of superfine compound pearl powder and its preparing process |
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Address after: 430056, No. three, No. 9, Maple Road, Wuhan economic and Technological Development Zone, Hubei, Wuhan Patentee after: FERGUSON (WUHAN) BIOTECHNOLOGY CO., LTD. Address before: 430056, No. three, No. 9, Maple Road, Wuhan economic and Technological Development Zone, Hubei, Wuhan Patentee before: Ferguson (Wuhan) Biological Technology Co., Ltd. |