CN1277532C - Pearl powder soft capsule - Google Patents
Pearl powder soft capsule Download PDFInfo
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- CN1277532C CN1277532C CNB2005100183747A CN200510018374A CN1277532C CN 1277532 C CN1277532 C CN 1277532C CN B2005100183747 A CNB2005100183747 A CN B2005100183747A CN 200510018374 A CN200510018374 A CN 200510018374A CN 1277532 C CN1277532 C CN 1277532C
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- decanoyl
- soft capsule
- pearl powder
- cera flava
- oil
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Abstract
The present invention relates to a pearl powder soft capsule with pearl powder as high-dried solids. The pearl powder soft capsule contains pearl powder and 4 to 39 wt% of decanoyl octanoyl glyceride. Through the addition of the decanoyl octanoyl glyceride which belongs to the intermediate carbon chain glyceride, the present invention can reduce the viscosity of the materials and can obviously improve the fluidity of the materials so that the preparation and the pill pressing work of the materials are easy. The pearl powder soft capsule contains more than 60% of pearl powder so that the volume of the soft capsule is greatly reduced and various effects of pearls are conveniently exerted.
Description
Technical field
The pearl powder soft capsule that to the present invention relates to a kind of high dry substance be Margarita powder.
Background technology
The soft capsule preparation worker wishes soft gelatin capsule is done as far as possible little, the user is swallowed as far as possible less and material that application target is irrelevant, and make swallow, transport, store more convenient.Dry solids content is (as Margarita powder) more for a long time, usually can make because of the viscous of material to make to meet difficulty.The approach that solves can be crushed to material enough fineness usually; Screen suitable suspending agent, reduce the consumption of suspending agent; Discharge the bubble that process for preparation is brought into; When above-mentioned way is invalid, have to strengthen the consumption of diluent, composition is divided into more unit, increase workload, the increasing made like this and manufacture cost, and make troubles to the user.
Margarita has tranquillizing the mind by relieving convulsion, improves sleep, regulates multiple effects such as immunity of organisms, supplement calcium, trace element and beauty treatment and eliminating spot.How with its pulverizing, even micronizing, be for external application or in take.Take orally and take with powder mostly.For increasing the utilization that is absorbed into of Margarita powder, from the last century end and the beginning of this century, many units have adopted superfine communication technique, make superfine Margarita powder supply the market (the described ultra-fine Margarita powder warp that is meant is less than 10 μ m).But pure Margarita powder has certain fishy smell, is difficult to adhere to directly taking for a long time.Be made into hard capsule individually, but superfine Margarita powder, density is little, and volume is big, takes inconvenience.
Margarita powder is made soft capsule, then can dwindle its volume greatly, be convenient to take and transport, preserve.Herbal pharmaceutical one factory of Shanghai medical material company proposes the patent of soft capsule of superfine compound pearl powder, number of patent application 00125898.2, because be difficult to overcome the difficulty that runs into viscosity in the Margarita powder making, the content of its Margarita ultrafine powder is 30%-60%, the ultra-fine pearl powder content can not further improve.
Decanoyl/octanoyl glycerides belongs to middle carbon chain fatty acid glyceride (MCT).And the carbochain of middle carbon chain fatty acid glyceride (MCT, MediumChain Triglycerides) is shorter, and the general vegetable oil of its viscosity ratio is at half above.Decanoyl/octanoyl glycerides system is by the mixture that contains the glyceride that 8 and 10 carbon atom saturated monocarboxylic acids are formed, carbon chain fatty acid glyceride (MCT) in belonging to.Its odorless, colourless; Ductility, lubricity are also good than other plant oil; Various lipids, fatsoluble vitamin there is good intermiscibility; Decanoyl/octanoyl glycerides all has good stability to high temperature and low temperature, the stability of oxidation is about 16 times of soybean oil.
The sixties in 20th century, medical circle began one's study MCT to the digesting and assimilating of human body, physiological property, to the adaptability of various diseases.Studies show that the infiltration rate of MCT in intestinal is faster than general oils and fats.Be hydrolyzed to fatty acid and glycerol rapidly at intestinal, to liver, be decomposed into CO rapidly through portal venous circulation
2And HxO, providing heat to body, metabolic speed is 8-10 times of LCT.Metabolism in vivo is also different with long-chain fatty acid (LCT), and it does not need to rely on the L-carnitine, does not form new fat in the body inner accumulated.Therefore, think that MCT can be used as the supplementary of rapid makeup energy; Help fat-reducing; Control too high cholesterol.Be applied to middle carbon chain fatty acid glyceride clinical successively.
A large amount of studies show that decanoyl/octanoyl glycerides is harmless, the oral LD of rat
50＞36ml/kg, lumbar injection＞24ml/kg; Intramuscular injection, skin and eye irritation test, the reproduction test of 2 generations, tertogenicity test, all negative.Confirmed as the GRAS material by U.S. FDA, also listed the use sanitary standard in China, Food Additives Used in China divides apoplexy due to endogenous wind to classify 10.018 as.In food additive, can be used as emulsifying agent and use, be used for the making of emulsifying essence, cosmetics, beverage, confection, chocolate, milk powder.But not seeing as yet so far has MCT to be used for the record that pearl powder soft capsule is made.
Summary of the invention
The object of the present invention is to provide the high pearl powder soft capsule of a kind of Margarita powder content.
To achieve these goals, technical scheme of the present invention is: a kind of pearl powder soft capsule, it comprises Margarita powder, it is characterized in that: also add decanoyl/octanoyl glycerides, the shared percentage by weight of the addition of decanoyl/octanoyl glycerides is 4-39%, and the each component sum is 100%.
Also can add vitamin E in the above-mentioned component, the shared percentage by weight of vitamin E is: 0-30%.
Also can add Cera Flava in the above-mentioned component, the shared percentage by weight of Cera Flava is: 0-1%.
Also can add the refining of edible vegetable oil in the above-mentioned component, the shared percentage by weight of refining of edible vegetable oil is: 0-35%, refining of edible vegetable oil are soybean salad oil, Semen Maydis oil, Semen Tritici aestivi germ oil or olive oil.
The shared percentage by weight of each component is: Margarita powder 61.1-95.0%, and decanoyl/octanoyl glycerides 4-39%, refining of edible vegetable oil 0.5-35, Cera Flava 0.1-1%, and to satisfy each component sum be 100%.
The shared percentage by weight of each component is: Margarita powder 61.1-95.0%, and decanoyl/octanoyl glycerides 4-39%, vitamin E 0.3-30%, refining of edible vegetable oil 0.5-35, Cera Flava 0.1-1%, and to satisfy each component sum be 100%.
The present invention adopts and adds the decanoyl/octanoyl glycerides that belongs to middle chain triglyceride, can reduce the viscosity of material, can obviously improve the flowability of material, makes the preparation of material and pelleting work become easy; Margarita powder content reaches more than 60% in its pearl powder soft capsule, has dwindled the volume of this soft capsule greatly, is convenient to bring into play the various effects of Margarita.
The specific embodiment
What enumerate below is to realize optimal way of the present invention.Adopt the higher limit or the lower limit of the addition of decanoyl/octanoyl glycerides can both realize purpose of the present invention; Component in the soft capsule is Margarita powder, decanoyl/octanoyl glycerides, refining of edible vegetable oil and Cera Flava, when perhaps the component in the soft capsule was Margarita powder, decanoyl/octanoyl glycerides, vitamin E, refining of edible vegetable oil and Cera Flava, wherein a certain component capping value or lower limit can both be realized purpose of the present invention; The each component sum is 100%.Embodiment just differs and one enumerates.
Embodiment 1:
Pearl powder soft capsule, it is made up of Margarita powder, decanoyl/octanoyl glycerides and Cera Flava, and the shared weight of each component is:
Margarita powder (the emerald green more pharmaceutcal corporation, Ltd of Zhejiang Zhuji City) 3000g
Soybean salad oil 1518g
Decanoyl/octanoyl glycerides 332g
Cera Flava (Dongguang County, Hebei drug packing material factory) 47.5g.
The preparation method of above-mentioned pearl powder soft capsule comprises the steps: 1). be by weight: Margarita powder 3000g, decanoyl/octanoyl glycerides 332g, soybean salad oil 1518g, Cera Flava 47.5g, choose Margarita powder, decanoyl/octanoyl glycerides, soybean salad oil, Cera Flava; 2). get decanoyl/octanoyl glycerides, soybean salad oil, Cera Flava, heat fused is made oily wax mixture; 3). oily wax mixture is added in the Margarita powder, stir, cross colloid mill or homogenizer, vacuum outgas then; By existing revolving die formula soft capsule processing technology, make 10000 soft capsules, Margarita powder content reaches 61.25%.
Embodiment 2:
The Compound Zhenzhu powder capsule, it is made up of Margarita powder, vitamin E, decanoyl/octanoyl glycerides, soybean salad oil and Cera Flava, and the shared weight of each component is:
Margarita powder (the emerald green more pharmaceutcal corporation, Ltd of Zhejiang Zhuji City) 3000g
Vitamin E (BASF AG) 200g
Soybean salad oil 1204g
Decanoyl/octanoyl glycerides 360g
Cera Flava (Dongguang County, Hebei drug packing material factory) 36g.
The preparation method of above-mentioned Compound Zhenzhu powder capsule, comprise the steps: 1). be by weight: Margarita powder 3000g, vitamin E 200g, decanoyl/octanoyl glycerides 360g, soybean salad oil 1204g, Cera Flava 36g, choose Margarita powder, vitamin E, soybean salad oil, decanoyl/octanoyl glycerides, Cera Flava; 2). get Margarita powder, add vitamin E and make compound; 3). get decanoyl/octanoyl glycerides, soybean salad oil, Cera Flava, heat fused is made oily wax mixture; 4). oily wax mixture is added in the compound, stir, cross colloid mill or homogenizer, vacuum outgas then; By existing revolving die formula soft capsule processing technology, adopt No. 5 mould, make 10000 soft capsules, Margarita powder content reaches 62.5%.
Embodiment 3:
The Compound Zhenzhu powder capsule, it is made up of Margarita powder, vitamin E, Semen Maydis oil, decanoyl/octanoyl glycerides and Cera Flava, and the shared weight of each component is:
Margarita powder (the emerald green more pharmaceutcal corporation, Ltd of Zhejiang Zhuji City) 3000g,
Vitamin E (BASF AG) 500g,
Semen Maydis oil (commercially available, Wuhan Zhong Chang vegetable oil company limited) 625g,
Decanoyl/octanoyl glycerides 471g,
Cera Flava (Dongguang County, Hebei drug packing material factory) 19.4g.
The preparation method of above-mentioned Compound Zhenzhu powder capsule, comprise the steps: 1). be by weight: Margarita powder 3000g, vitamin E 500g, Semen Maydis oil 625g, decanoyl/octanoyl glycerides 471g, Cera Flava 19.4g, choose Margarita powder, vitamin E, Semen Maydis oil, decanoyl/octanoyl glycerides, Cera Flava; 2). get Margarita powder, add vitamin E and make compound; 3). get decanoyl/octanoyl glycerides, Semen Maydis oil, Cera Flava, heat fused is made oily wax mixture; 4). oily wax mixture is added in the compound, stir, cross colloid mill or homogenizer, vacuum outgas then; By existing revolving die formula soft capsule processing technology, adopt No. 5 mould, make 10000 soft capsules, Margarita powder content reaches 65%.
Embodiment 4:
The Compound Zhenzhu powder capsule, it is made up of Margarita powder, vitamin E, olive oil, decanoyl/octanoyl glycerides and Cera Flava, and the shared weight of each component is:
Margarita powder (the emerald green more pharmaceutcal corporation, Ltd of Zhejiang Zhuji City) 3000g,
Vitamin E (BASF AG) 600g,
Olive oil (Spain's import) 240g,
Decanoyl/octanoyl glycerides 562g,
Cera Flava (Dongguang County, Hebei drug packing material factory) 10g.
The preparation method of above-mentioned Compound Zhenzhu powder capsule, comprise the steps: 1). be by weight: Margarita powder 3000g, vitamin E 600g, olive oil 240g, decanoyl/octanoyl glycerides 562g, Cera Flava 10g, choose Margarita powder, vitamin E, olive oil, decanoyl/octanoyl glycerides, Cera Flava; 2). get Margarita powder, add vitamin E and make compound; 3). get olive oil, decanoyl/octanoyl glycerides, Cera Flava, heat fused is made oily wax mixture; 4). oily wax mixture is added in the compound, stir, cross colloid mill or homogenizer, vacuum outgas then; By existing revolving die formula soft capsule processing technology, adopt No. 5 mould, make 10000 soft capsules.Margarita powder content reaches 68%.
Embodiment 5:
The Compound Zhenzhu powder capsule, it is made up of Margarita powder, vitamin E, Semen Tritici aestivi germ oil, decanoyl/octanoyl glycerides, Cera Flava, and the shared weight of each component is:
Margarita powder (the emerald green more pharmaceutcal corporation, Ltd of Zhejiang Zhuji City) 3000g,
Vitamin E (BASF AG) 100g,
Edible vegetable oil (commercially available) 307g,
Decanoyl/octanoyl glycerides 965g,
Cera Flava (Dongguang County, Hebei drug packing material factory) 7g.
The preparation method of above-mentioned Compound Zhenzhu powder capsule, comprise the steps: 1). be by weight: Margarita powder 3000g, vitamin E 100g, Semen Tritici aestivi germ oil 307g, decanoyl/octanoyl glycerides 965g, Cera Flava 7g, choose Margarita powder, vitamin E, Semen Tritici aestivi germ oil, decanoyl/octanoyl glycerides, Cera Flava; 2). get Margarita powder, adding vitamin E, Semen Tritici aestivi germ oil are made compound; 3). get decanoyl/octanoyl glycerides, Cera Flava, heat fused is made oily wax mixture; 4). oily wax mixture is added in the compound, stir, cross colloid mill or homogenizer, vacuum outgas then; Press revolving die formula soft capsule processing technology, adopt No. 5 mould, make 10000 soft capsules, Margarita powder content reaches 68.5%.
Claims (3)
1. pearl powder soft capsule, it comprises Margarita powder, it is characterized in that: also add decanoyl/octanoyl glycerides, the shared percentage by weight of the addition of decanoyl/octanoyl glycerides is 4-39%; Also add vitamin E, the shared percentage by weight of vitamin E is: 0-30%; Also add Cera Flava, the shared percentage by weight of Cera Flava is: 0-1%; Also add the refining of edible vegetable oil, the shared percentage by weight of refining of edible vegetable oil is: 0-35%, described refining of edible vegetable oil is soybean salad oil, Semen Maydis oil, Semen Tritici aestivi germ oil or olive oil, and to satisfy each component sum be 100%.
2. a kind of pearl powder soft capsule according to claim 1, it is characterized in that: the shared percentage by weight of each component is: Margarita powder 61.1-95.0%, decanoyl/octanoyl glycerides 4-39%, refining of edible vegetable oil 0.5-35%, Cera Flava 0.1-1%, and to satisfy each component sum be 100%.
3. a kind of pearl powder soft capsule according to claim 1, it is characterized in that: the shared percentage by weight of each component is: Margarita powder 61.1-95.0%, decanoyl/octanoyl glycerides 4-39%, vitamin E 0.3-30%, refining of edible vegetable oil 0.5-35%, Cera Flava 0.1-1%, and to satisfy each component sum be 100%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100183747A CN1277532C (en) | 2005-03-14 | 2005-03-14 | Pearl powder soft capsule |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100183747A CN1277532C (en) | 2005-03-14 | 2005-03-14 | Pearl powder soft capsule |
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| Publication Number | Publication Date |
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| CN1682767A CN1682767A (en) | 2005-10-19 |
| CN1277532C true CN1277532C (en) | 2006-10-04 |
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| CNB2005100183747A Active CN1277532C (en) | 2005-03-14 | 2005-03-14 | Pearl powder soft capsule |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105495595A (en) * | 2015-12-23 | 2016-04-20 | 太仓东浔生物科技有限公司 | Pearl containing buccal tablets and preparation method |
| CN106165905B (en) * | 2016-07-07 | 2019-05-03 | 海南正康药业有限公司 | A kind of calcium adds vitamine soft capsule and preparation method |
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Owner name: FERGUSON (WUHAN) BIOTECHNOLOGIES LIMITED Free format text: FORMER NAME: FUGESEN HEALTH CARE FOOD CO., LTD,. WUHAN CITY |
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Address after: 430056, No. three, No. 9, Maple Road, Wuhan economic and Technological Development Zone, Hubei, Wuhan Patentee after: Ferguson (Wuhan) Biological Technology Co., Ltd. Address before: 430056, building 8, hi tech Industrial Park, Wuhan economic and Technological Development Zone, Wuhan, Hubei Patentee before: Fugesen Health Food Co., Ltd., Wuhan |
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Owner name: FERGUSON (WUHAN) BIOTECHNOLOGY CO., LTD. Free format text: FORMER NAME: FERGUSON (WUHAN) BIOTECHNOLOGIES LIMITED |
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Address after: 430056, No. three, No. 9, Maple Road, Wuhan economic and Technological Development Zone, Hubei, Wuhan Patentee after: FERGUSON (WUHAN) BIOTECHNOLOGY CO., LTD. Address before: 430056, No. three, No. 9, Maple Road, Wuhan economic and Technological Development Zone, Hubei, Wuhan Patentee before: Ferguson (Wuhan) Biological Technology Co., Ltd. |