CN1078198C - Process for extracting linolenic acid and producing soft capsules using linolenic acid - Google Patents
Process for extracting linolenic acid and producing soft capsules using linolenic acid Download PDFInfo
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- CN1078198C CN1078198C CN96120281A CN96120281A CN1078198C CN 1078198 C CN1078198 C CN 1078198C CN 96120281 A CN96120281 A CN 96120281A CN 96120281 A CN96120281 A CN 96120281A CN 1078198 C CN1078198 C CN 1078198C
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- linolenic acid
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Abstract
The present invention discloses a production process for extracting alpha-linolenic acid from perilla seeds and preparing soft capsules from the alpha-linolenic acid. The present invention has the specific method that the perilla seeds are squeezed and filtered, and the refined perilla oil comprises 40 to 75% of alpha-linolenic acid. The perilla oil and vitamin E are mixed according to the proportion of 1000:0.5 to 10 so as to form contents of the soft capsules, and the capsules are pressed with capsule wall materials.
Description
The invention relates to the extraction process of alpha-linolenic acid, this alpha-linolenic acid has the adjustment serum lipid concentrations, reducing cholesterol, triglyceride, high density lipoprotein increasing and increase the effect that the intelligence benefit is looked the invention still further relates to the soft capsule and oral liquid and the preparation technology thereof that contain alpha-linolenic acid.
Along with the progress of science, people have many new discoveries to the progress of human body biochemistry.Numerous scientists think, the imbalance of the serial unsaturated fatty acids of ω-3/ ω-6 has significant relation in the development of many chronic diseases and the health, at present, the ratio of the serial unsaturated fatty acids of intravital ω-3/ ω-6 is all less than 5: 1 under the general state, desire to keep 5: 1 equilibrium relationships of the serial unsaturated fatty acids of ω-3/ ω-6 in the body, the serial unsaturated fatty acids of additional ω-3 that will be artificial.Alpha-linolenic acid is that the serial unsaturated fatty acids of ω-3 enters the parent of human body, and is the serial unsaturated fatty acids of unique ω that extracts from plant-3.Can obtain linolenic plant at present has Oenothera oil (gamma-linolenic acid) not see from purple perilla to extract the report that alpha-linolenic acid is made oral preparations.But oral Evening Primrose Oil is efficient low to the treatment cardiovascular disorder, and after taking DeGrain in a short time, major cause is a gamma-linolenic acid content low (8-10% weight) in the Oenothera oil; Oenothera oil is a triglyceride, and is slow in human body metabolism's speed, and most of Oenothera oil just is excreted before the epoxidation not carrying out.Therefore, select a kind of suitable plant as extracting raw material, the technology of particularly inventing a kind of uniqueness is used to prepare the superior oral drug preparation of medical effect to obtain highly purified alpha-linolenic acid, is one of current major issue that needs solution.
The purpose of this invention is to provide a kind of technology of from perilla oil, extracting alpha-linolenic acid;
Another object of the present invention provides a kind of oral soft capsule of making of alpha-linolenic acid;
Another object of the present invention provides a kind of perilla oil oral liquid.
The technical scheme that realizes the object of the invention comprises the steps:
1, chooses raw material
Select pure perilla seed, do further selected;
2, perilla seed is squeezed under 61-70 ℃ temperature, the control oil yield makes the oil that squeezes out place precipitation 24-50 hours 35-45%, filters, and gets pressed oil;
3, washed 5.5-7 minutes with 6.5 or 7-10% sodium bicarbonate, place 24 or 30-40 hours, wash with sterilized water, being washed till the pH value is 6-8, must make with extra care perilla oil;
4, the purified perilla oil is put into container, inflated with nitrogen, sealing, lucifuge, cryopreservation.
The preparation technology of perilla oil of the present invention is preferably following steps:
1, chooses raw material
Select pure perilla seed, do further selected;
2, perilla seed is squeezed under 65 ℃ temperature, the control oil yield makes the oil that squeezes out place precipitation 41-45 hours 41-45%, filters, and gets pressed oil;
3, washed 6 minutes with 8% sodium bicarbonate, placed 35-40 hours, preferred 38 hours, wash with sterilized water again, being washed till the pH value is 7, must make with extra care perilla oil;
4, the purified perilla oil is put into container, inflated with nitrogen, sealing, lucifuge, cryopreservation.
The extraction process of alpha-linolenic acid of the present invention is:
Select pure perilla seed, perilla seed is squeezed under 50-70 ℃ temperature, the control oil yield is 35-45%, make the oil that squeezes out place precipitation 24-40 hours, filter, get pressed oil, pressure measurement oil expression acid number and peroxide value, in the calculating and alkali charge, fit over 5-10% sodium bicarbonate, wash agitation is 20-50 minutes under 20-30 ℃ of temperature, is heated to 50-75 ℃, left standstill 24-48 hours, emit the buck soap stock, use 5-10% sodium-chlor continuous washing of 1-3 times of amounts again and stir 60-80 ℃ of heating holding temperatures, emit the sodium-chlor water layer, the gac and 0.8-3.5% white bole of adding 1.5-11% continue 1-3 hours, behind the naturally cooling, the purified perilla oil is put into vacuum vessel, be heated to 50-80 ℃, vacuumize, vacuum tightness maintains 8-35mmHg, secondary repeatedly, filter through filter plate, add 0.05-1% vitamin-E, inflated with nitrogen, sealing, the lucifuge cryopreservation, the alpha-linolenic acid content 40-75% of refining perilla oil, acid number≤4, peroxide value≤12meg/kg, carbonyl value≤20meg/kg, iodine number 170-190, saponification value 185-205, relative density 0.8532-0.9900, diopter 1.0000-1.9900.
The refining perilla oil soft capsule that contains alpha-linolenic acid 40-70% of the present invention comprises content and capsule material:
The content weight proportion of composing is refining perilla oil: vitamin-E=1000: (0.5-10);
Capsule material weight proportion of composing is a gelatin: glycerine: water=1: (0.2-0.5): (0.8-1.5)
The ratio of foregoing thing and capsule material is soft capsule preparation technology and deciding routinely.
The production technique of described soft capsule comprises gelatin, glycerine, water is added in the colloidal sol capsule, and 50-80 ℃ of temperature are stored in the insulation jar standby after the dissolving; With the purified perilla oil closed tin of packing into, the bubble of bleeding; Storage glue jar is heated to 50-65 ℃ and draws film, gauge control between 35-40 little lattice, every lattice=0.0254 millimeter, outward appearance is rectified when pressing grain, the junction must not be lower than 1/3; Capsule after the compacting will keep washing secondary with zellon after 2 hours in the capsule drum, enters the kiln moulding again, 25 ℃ ± 2 ℃ of controlled temperature, and humidity is below 45%, 72 hours time, stirred once in per 30 minutes, be then packed in the bottle or in the aluminium foil plate.
Perilla oil oral liquid of the present invention is made up of the each component of following weight ratio:
Refining perilla oil 5-50%
Fabaceous lecithin 5-50%
Vitamin e1-5%
Distilled water 10-89%
Above-mentioned refining perilla oil contains alpha-linolenic acid 30-90%.
The preparation method of oral liquid of the present invention is:
With perilla oil in the above each component and vitamin-E mixing, earlier water and emulsifying agent are entered colloidal mill, insert perilla oil after, circulate repeatedly 2-5 times, each 5-10 minutes, insert and shake equal machine 2-4 times, each 5-8 minutes, the airtight bottle of packing into, went out all at lucifuge.
The perilla oil that the inventive method is extracted is compared with other perilla oil extracting method has outstanding advantage:
1, the perilla oil purity height of the inventive method preparation, alpha-linolenic acid content wherein can reach 62-75% (g/g);
2, because extraction process of the present invention makes that the content of alpha-linolenic acid increases in the perilla oil, reduced the toxicity of perilla oil, show through the chmice acute toxicity test, the maximum tolerated dose of oral this medicine of perilla oil is equivalent to 60kg body weight people's 771.4 times of clinical consumption, thereby the safety in utilization of perilla oil is provided widely.
3, owing to the raising of purity and safety in utilization, enlarged the DEVELOPMENT PROSPECT of perilla oil, the perilla oil that technology of the present invention is extracted can be used to prepare medicine, nutrient fortified food such as edible oil, milk etc.
4, the perilla oil of technology extraction of the present invention has a series of diseases that treatment body fat metabolism metabolism disorder produces, as atherosclerosis, coronary heart disease, hypertension, diabetes, fatty liver etc.
Medicine of the present invention has been broken through the limitation that traditional medicine is used perilla seed, is a kind of novel formulation of purification of tcm.
Experiment shows: promptly there was the effect of tangible reducing total cholesterol and triglyceride content in 4 weeks after the perilla oil medication.Medication 8 all backs reducing total cholesterol are efficient to be 61.4%, and than Oenothera oil (42.5%) height, the triglyceride reducing total effective rate is 61.3%, also than Oenothera oil (46.1%) height.Therefore, the perilla oil that technology of the present invention is extracted has the effect of tangible blood fat reducing, is a kind of grease of antilipemic healthy safely and effectively.
Embodiment 1
Select pure perilla seed, perilla seed is squeezed under 61 ℃ temperature, the control oil yield makes the oil that squeezes out place precipitation 24 hours 35%, filters, and gets pressed oil;
Sodium bicarbonate with 7% boiled 5.5 minutes, placed 24 hours, washed with sterilized water again, and being washed till the pH value is 6, must make with extra care perilla oil;
The purified perilla oil is put into container, inflated with nitrogen, sealing, lucifuge, cryopreservation.
Embodiment 2
Select pure perilla seed, perilla seed is squeezed under 70 ℃ temperature, the control oil yield makes the oil that squeezes out place precipitation 50 hours 45%, filters, and gets pressed oil;
Washed 7 minutes with 10% sodium bicarbonate, placed 40 hours, wash with sterilized water, being washed till the pH value is 8, must make with extra care perilla oil;
The purified perilla oil is put into container, inflated with nitrogen, sealing, lucifuge, cryopreservation.
Embodiment 3
Select pure perilla seed, perilla seed is squeezed under 65 ℃ temperature, the control oil yield makes the oil that squeezes out place precipitation 41 hours 41%, filters, and gets pressed oil;
Washed 6 minutes with 8% sodium bicarbonate, placed 35 hours, wash with sterilized water, being washed till the pH value is 7, must make with extra care perilla oil;
The purified perilla oil is put into container, inflated with nitrogen, sealing, lucifuge, cryopreservation.
Embodiment 4
Select pure perilla seed, perilla seed is squeezed under 65 ℃ temperature, the control oil yield makes the oil that squeezes out place precipitation 45 hours 45%, filters, and gets pressed oil;
Washed 6 minutes with 8% sodium bicarbonate, placed 38 hours, wash with sterilized water, being washed till the pH value is 7, must make with extra care perilla oil;
The purified perilla oil is put into container, inflated with nitrogen, sealing, lucifuge, cryopreservation.
Embodiment 5
Select pure perilla seed, perilla seed is squeezed under 67 ℃ temperature, the control oil yield makes the oil that squeezes out place precipitation 41 hours 41%, filters, and gets pressed oil;
Washed 6.5 minutes with 6.5% sodium bicarbonate, placed 30 hours, wash with sterilized water, being washed till the pH value is 7.8, must make with extra care perilla oil;
The purified perilla oil is put into container, inflated with nitrogen, sealing, lucifuge, cryopreservation.
Embodiment 6
Select pure perilla seed, perilla seed is squeezed under 64 ℃ temperature, the control oil yield makes the oil that squeezes out place precipitation 43 hours 42%, filters, and gets pressed oil;
Washed 7 minutes with 7.8% sodium bicarbonate, placed 24 hours, wash with sterilized water, being washed till the pH value is 7.6, must make with extra care perilla oil;
The purified perilla oil is put into container, inflated with nitrogen, sealing, lucifuge, cryopreservation.
Claims (5)
1, a kind of method of extracting alpha-linolenic acid from perilla seed is characterized in that this method comprises the steps:
Select pure perilla seed, perilla seed is squeezed under 50-70 ℃ temperature, the control oil yield is 35-45%, make the oil that squeezes out place precipitation 24-40 hours, filter, pressed oil: pressure measurement oil expression acid number and peroxide value in the calculating and alkali charge, are made into 5-10% sodium bicarbonate, wash agitation is 20-50 minutes under 20-30 ℃ of temperature, be heated to 50-75 ℃, left standstill 24-48 hours, emit the buck soap stock, use 5-10% sodium-chlor continuous washing and the stirring of 1-3 times of amounts again, 60-80 ℃ of heating holding temperatures are emitted the sodium-chlor water layer, add 1.5-11% gac and 0.8-3.5% white bole, continue 1-3 hours, behind the naturally cooling, the purified perilla oil is put into vacuum vessel, be heated to 50-80 ℃, vacuumize, vacuum tightness maintains 8-35mmHg, and secondary filters through filter plate repeatedly, the vitamin-E of adding 0.05-1%, inflated with nitrogen, sealing, lucifuge cryopreservation, the alpha-linolenic acid content 40-75% of refining perilla oil, acid number≤4, peroxide value≤12meg/kg, carbonyl value≤20meg/kg, iodine number 170-190, saponification value 185-205, relative density 0.8532-0.9900, diopter 1.0000-1.9900.
2, a kind of method of refining perilla oil is characterized in that this method comprises the steps:
Select pure perilla seed, perilla seed is squeezed under 61-70 ℃ temperature, the control oil yield is 35-45%, make the oil that squeezes out place precipitation 24-50 hours, filter, get pressed oil: washed 5.5-7 minutes with 6.5 or 7-10% sodium bicarbonate, place 24 or 30-40 hours, wash with sterilized water, being washed till pH value is 6-8, must make with extra care perilla oil again; The purified perilla oil is put into container, inflated with nitrogen, sealing, lucifuge, cryopreservation.
3,, it is characterized in that this method comprises the steps: according to the method for claim 2
Select pure perilla seed, perilla seed is squeezed under 67 ℃ temperature, the control oil yield makes the oil that squeezes out place precipitation 41 hours 41%, filters, and gets pressed oil; Sodium bicarbonate with 6.5% boiled 6.5 minutes, placed 30 hours, washed with sterilized water again, and being washed till pH value is 7.8, must make with extra care perilla oil;
The purified perilla oil is put into container, inflated with nitrogen, sealing, lucifuge, cryopreservation.
4,, it is characterized in that this method comprises the steps: according to the method for claim 2
Select pure perilla seed, perilla seed is squeezed under 64 ℃ temperature, the control oil yield makes the oil that squeezes out place precipitation 43 hours 42%, filters, and gets pressed oil; Washed 7 minutes with 7.8% sodium bicarbonate, placed 24 hours, wash with sterilized water, being washed till pH value is 7.6, must make with extra care perilla oil; The purified perilla oil is put into container, inflated with nitrogen, sealing, lucifuge, cryopreservation.
5, method according to claim 2 is characterized in that this method comprises following steps:
Select pure perilla seed, perilla seed is squeezed under 65 ℃ temperature, the control oil yield makes the oil that squeezes out place precipitation 41 hours 41%, filters, and gets pressed oil; Washed 6 minutes with 8% sodium bicarbonate, placed 35 hours, wash with sterilized water, being washed till pH value is 7, must make with extra care perilla oil; The purified perilla oil is put into container, inflated with nitrogen, sealing, lucifuge, cryopreservation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN96120281A CN1078198C (en) | 1996-11-04 | 1996-11-04 | Process for extracting linolenic acid and producing soft capsules using linolenic acid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN96120281A CN1078198C (en) | 1996-11-04 | 1996-11-04 | Process for extracting linolenic acid and producing soft capsules using linolenic acid |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN99127321A Division CN1102065C (en) | 1999-12-29 | 1999-12-29 | Process for extracting linoleic acid and producing soft capsule contg. linoleic acid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1156716A CN1156716A (en) | 1997-08-13 |
| CN1078198C true CN1078198C (en) | 2002-01-23 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN96120281A Expired - Fee Related CN1078198C (en) | 1996-11-04 | 1996-11-04 | Process for extracting linolenic acid and producing soft capsules using linolenic acid |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100418633C (en) * | 2005-03-28 | 2008-09-17 | 武汉工业学院 | Technology for perilla seed peeling oil pressing at low temparatnre |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100400038C (en) * | 2005-10-28 | 2008-07-09 | 江苏瑞迪生科技有限公司 | Compound soft lutein capsule and its prepn process |
| CN100363326C (en) * | 2005-12-30 | 2008-01-23 | 安阳化学工业集团有限责任公司 | Process for preparing alpha-linolenic acid with purity more than 80% |
| CN101717695B (en) * | 2009-11-13 | 2011-11-23 | 广东亿超生物科技有限公司 | Method for effectively reducing peroxidation value of nature fats |
| CN101940292B (en) * | 2010-07-26 | 2012-09-05 | 无锡市天赐康生物科技有限公司 | Health-care food for assisting in improving memory function and preparation method thereof |
| CN102687861A (en) * | 2011-03-24 | 2012-09-26 | 辽宁今日农业有限公司 | Raspberry seed oil soft capsule and preparation method thereof |
| CN103461993A (en) * | 2013-08-02 | 2013-12-25 | 新疆天山骄子食品有限责任公司 | Linolenic acid capsule production process |
| CN103919841B (en) * | 2014-03-19 | 2017-04-19 | 河南大学 | Method for prolonging shelf life of eucommia ulmoides seed oil soft capsules |
| CN105219524A (en) * | 2015-10-19 | 2016-01-06 | 南昌大学 | A kind of extracting method of perilla oil |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63295698A (en) * | 1987-05-27 | 1988-12-02 | Showa Denko Kk | Separation and purification of alpha-linolenic acid |
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1996
- 1996-11-04 CN CN96120281A patent/CN1078198C/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63295698A (en) * | 1987-05-27 | 1988-12-02 | Showa Denko Kk | Separation and purification of alpha-linolenic acid |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100418633C (en) * | 2005-03-28 | 2008-09-17 | 武汉工业学院 | Technology for perilla seed peeling oil pressing at low temparatnre |
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|---|---|
| CN1156716A (en) | 1997-08-13 |
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