CN118104678A - Ternary weeding composition containing ciclopirox and quinclorac and application thereof - Google Patents

Abstract

The invention belongs to the field of pesticides, and particularly relates to a ternary weeding composition containing ciclopirox and quinclorac and application thereof. The ternary weeding composition comprises an active ingredient A, an active ingredient B and an active ingredient C in herbicidally effective amounts, wherein the active ingredient A is ciclopirox; the active component B is quinclorac; the active ingredient C is selected from one of the following compounds: atrazine, terbuthylazine. The composition can effectively prevent and kill off various weeds such as gramineae weeds, broadleaf weeds and the like, and has the characteristics of expanding a weed killing spectrum, reducing application amount, generating synergistic effect, solving resistant weeds and the like.

Description

Ternary weeding composition containing ciclopirox and quinclorac and application thereof

Technical Field

The invention belongs to the field of pesticides, and particularly relates to a ternary weeding composition containing ciclopirox and quinclorac and application thereof.

Background

Chemical weeding is the most economical and effective means in farmland weed control, but long-term continuous high-dosage chemical herbicide with single variety or single action mode is easy to cause problems of weed resistance, resistance evolution and the like.

Cyclopyralid belongs to a novel HPPD herbicide, and by inhibiting the activity of HPPD, the process of converting p-hydroxyphenylpyruvic acid into homogentisate is blocked, so that tocopherol and plastoquinone cannot be normally synthesized, the synthesis of carotenoid in a target body is influenced, the leaves are whitened, the action mechanism is unique, and gramineous weeds and part of broadleaf weeds such as resistant and multi-resistant alopecias, japanese alopecias and the like can be effectively solved.

The reasonable compounding or compounding of the herbicide compound has the advantages of expanding the weed spectrum, improving the preventing and killing effect, delaying the occurrence and development of weed resistance and drug resistance, and the like, and is one of the most effective methods for solving the problems. Therefore, there is a need in the art to develop herbicidal compositions that are highly safe, broad-spectrum, synergistic and resistant to weeds.

Disclosure of Invention

In order to solve the problems in the prior art, the invention provides a ternary weeding composition containing ciclopirox olamine and quinclorac and application thereof, and the composition can effectively prevent and remove various weeds such as grasses, broadleaf weeds and the like, and has the characteristics of expanding a weed killing spectrum, reducing application amount, generating synergistic effect, solving resistant weeds and the like.

A ternary herbicidal composition comprising ciclopirox and quinclorac, which is characterized by comprising a herbicidally effective amount of an active ingredient A, an active ingredient B and an active ingredient C, wherein,

The active ingredient A is ciclopirox olamine (CAS number: 1855929-45-1);

The active ingredient B is quinclorac (CAS number: 84087-01-4);

The active ingredient C is selected from one of the following compounds: atrazine (CAS number: 1912-24-9), terbuthylazine (CAS number: 5915-41-3).

Wherein, the weight ratio of A, B to C is 1-150:1-500:1-1000, 20-100:50-250:100-800, 30-90:70-200:150-600 or 40-70:80-180:200-400.

In a specific embodiment, the herbicidal composition is selected from any one of the following:

the active component A is ciclopirox, the active component B is quinclorac, the active component C is atrazine, the weight ratio of A, B to C is 20-100:50-250:150-800, preferably 22.5-90:56.25-225:187.5-750;

The active component A is ciclopirox, the active component B is quinclorac, the active component C is terbuthylazine, the weight ratio of A, B to C is 20-100:50-250:100-500, and the preferential weight ratio is 22.5-90:56.25-225:112.5-450.

The mass percentage of A, B and C in the weeding composition accounts for 1-95%, preferably 10-80% of the total mass.

The herbicidal composition further comprises conventional adjuvants including carriers and/or surfactants.

The term "carrier" as used herein means an organic or inorganic, natural or synthetic substance. They facilitate the application of the active ingredient, which carriers are generally inert and must be agriculturally acceptable, in particular by the treated plants. The carrier may be solid, such as clay, natural or synthetic silicate, silica, resin, wax, solid fertilizer, etc.; or liquid, such as water, alcohols, ketones, petroleum fractions, aromatic or waxy hydrocarbons, chlorinated hydrocarbons, liquefied gases, and the like.

Surfactants may include emulsifiers, dispersants or wetting agents, which may be ionic or nonionic. Examples which may be mentioned are salts of polyacrylic acid, lignosulfonates, salts of phenolsulfonic acid or naphthalenesulfonic acid, polymers of ethylene oxide with aliphatic alcohols or with aliphatic amines with substituted phenols, in particular alkylphenols or arylphenols, sulfosuccinates, taurine derivatives, in particular taurates, and phosphates of alcohols or of polyethylated phenols, alkylsulfonates, alkylaryl sulfonates, alkyl sulfates, lauryl ether sulfates, fatty alcohol sulfates, and also sulfated hexadecyl-, heptadeca-and octadecanols and sulfated fatty alcohol glycol ethers, furthermore condensates of naphthalene or naphthalenesulfonic acid with phenol and formaldehyde, polyoxyethylene octylphenyl ether, ethoxylated isooctylphenols, octylphenols or nonylphenols, alkylphenyl polyglycol ethers, tributylphenyl polyglycol ethers, tristearylphenyl polyglycol ethers, alkylaryl polyether alcohols, alcohol and fatty alcohol/ethylene oxide condensates, ethoxylated castor oil, polyoxyethylene alkyl ethers, ethoxylated polyoxypropylene, lauryl alcohol polyglycol ethers, sorbitol esters, lignin sulfite waste solutions, and also proteins, polysaccharides (e.g. methylcellulose), polyvinyl alcohol, hydrophobically modified polyvinyl pyrrolidone, polyvinyl alcohol carboxylate, polyvinyl pyrrolidone, and copolymers thereof. At least one surfactant is required to be present to facilitate the dispersion of the active ingredients in water and to enable them to be applied correctly to the plants.

The above-described compositions may also contain various other components such as protective colloids, binders, thickeners, thixotropic agents, penetrating agents, stabilizers, chelating agents, dyes, colorants and polymers.

The herbicidal composition further comprises at least one safener, preferably one or more of bisbenzoxazole acid (CAS: 163520-33-0), cyprosulfamide (CAS: 221667-31-8), pyraclonil (CAS: 135590-91-9), cloquintocet-mexyl (CAS: 99607-70-2), gibberellic acid (CAS: 7-06-5), furilazole (CAS: 121776-33-8), metcamifen (CAS: 129531-12-0).

In the context of the present specification, if the abbreviated form of the generic name of the active compound is used, all customary derivatives, such as esters and salts, as well as isomers, in particular optical isomers, in particular one or more commercially available forms, are included in each case. If the generic name denotes esters or salts, all other customary derivatives are also included in each case, such as other esters and salts, free acids and neutral compounds, as well as isomers, in particular optical isomers, in particular one or more commercially available forms. The chemical name given to a compound means at least one compound covered by a common name, generally the preferred compound. In the case of sulfonamides such as sulfonylureas, salts also include salts formed by the exchange of cations with hydrogen atoms in the sulfonamide group.

In the context of the present invention, the salts of the compounds are preferably in the form of the respective alkali metal, alkaline earth metal or ammonium salts, preferably in the form of the respective alkali metal salts, more preferably in the form of the respective sodium or potassium salts, most preferably in the form of the respective sodium salts.

The compositions of the present invention may be diluted by the user prior to use or used directly. The preparation can be prepared by common processing method, namely, mixing the active substance with liquid solvent or solid carrier, and adding one or more surfactants such as dispersing agent, stabilizer, wetting agent, adhesive, defoamer, etc.

The specific preparation of the weeding composition is dispersible oil suspending agent, water suspending agent, suspending emulsion, wettable powder, emulsifiable concentrate, water dispersible granule (dry suspending agent), water emulsion and microemulsion.

Briefly, the compositions of the present invention can be mixed with solid and liquid additives conventionally used in prior art formulations. The amount of the active ingredient used varies with the external conditions such as temperature, humidity, the nature of the herbicide used, and the like. It may have a large variation, for example between 0.001 and 1.0kg/ha, or more, of active substance, but preferably between 0.005 and 750g/ha, in particular between 0.005 and 500 g/ha.

In addition, the compositions of the invention can be applied by spraying onto the foliage of the plants to be treated, i.e. onto weeds, in particular onto surfaces which are infested or susceptible to infestation by weeds.

Further, the invention also provides application of the weeding composition in weed control; and a method of controlling unwanted plant growth comprising applying the herbicidal composition to plants, plant parts, plant seeds or areas of plant growth. Preferably, the herbicidal composition is used to selectively control weeds in crops of useful plants, more preferably in crops of useful plants which have been treated by transgenic or genome editing techniques.

The compounds of the invention are useful for treating all plants and plant parts. Plant varieties and cultivars can be obtained by conventional breeding and breeding methods or by genetic engineering methods. Genetically modified plants (transgenic plants) are those in which a heterologous gene (transgene) has been stably integrated into the genome of the plant. The transgene defined by its specific location in the plant genome is referred to as a transformation event or transgenic event.

Genetically modified plant cultivars that can be treated according to the invention include those that are resistant to one or more biotic stresses (pests such as nematode animals, insects, mites, fungi, etc.) or abiotic stresses (drought, low temperature, soil salinization, etc.), or which contain other desirable characteristics. Plants can be genetically modified to exhibit traits such as herbicide tolerance, insect tolerance, modified oil characteristics, or drought tolerance. Information on available genetically modified plants comprising a single gene transformation event or a combination of transformation events can be obtained from publicly available databases maintained, for example, by the U.S. department of agriculture.

When the herbicidal composition of the present invention is applied, its herbicidal activity achieves unexpected synergistic effects with respect to a single agent and any binary composition therein. The synergistic effect is manifested by a reduced application rate, a broader weed control spectrum, a faster and more durable herbicidal action, which are desirable in the practice of weed control. These new compositions are significantly superior to existing herbicides in terms of the characteristics described, achieving reduced use and being more environmentally friendly.

The synergistic weeding composition provided by the invention also has the following advantages:

(1) The composition of the invention is environment-friendly and is easy to degrade in the environment.

(2) The weeding composition disclosed by the invention is low in cost and convenient to use, and has great economic and social benefits in popularization and application.

Detailed Description

The following examples are not intended to limit the invention but are merely illustrative of how the invention may be practiced. For certain weeds, these examples showed particularly significant effectiveness. Examples are as follows:

A) Examples

1. Cyclopyralid, quinclorac and atrazine (3+10+25) water dispersible granule

3% Ciclopirox, 10% quinclorac, 25% atrazine, 5% precipitated silica, 5% NNO, 3% nekal, 5% polycarboxylate dispersant, 10% ammonium sulfate, 5% sucrose and kaolin

2. Cyclopyralid, quinclorac and terbuthylazine (3+10+15) water suspending agent

3% Of ciclopirox olamine, 10% of quinclorac, 15% of terbuthylazine, 4% of phenethyl phenol polyoxyethylene ether phosphate triethanolamine salt, 2% of comb polycarboxylate, 2% of fatty alcohol polyoxyethylene ether, 0.12% of xanthan gum, 1.2% of magnesium aluminum silicate, 0.1% of defoamer, 0.05% of kathon, 5% of glycol and deionized water are used for the balance

The water suspending agent processing equipment comprises: mixing kettle, colloid mill, sand mill, shearing machine, etc.

The processing process of the water suspending agent comprises the following steps: all materials are put into a mixing kettle, stirred and mixed, then the materials are subjected to a colloid mill, and finally enter a sand mill for three-stage sand milling, finally the materials are uniformly sheared in a shearing machine, and after the materials are tested to be qualified, the materials are transferred to a storage tank for filling.

Above-mentioned water dispersible granule processing equipment: mechanical pulverizer, jet mill, coulter mixer, basket granulator, drying oven, sieving machine, etc.

The processing process of the water dispersible granule comprises the following steps: after the materials are uniformly mixed, mechanical crushing is carried out, then airflow crushing is carried out, water is added for uniform mixing, then kneading granulation is carried out, drying and granulating are carried out after granulation, and finally screening is carried out, thus obtaining the finished product.

B) Test of efficacy

1) Test target: all-grass of Tiger grass.

2) Reagent: the raw materials are all diluted by using acetone as solvent and 0.1% of emulsifier Tween-80 aqueous solution, and the diluted materials are diluted at present.

3) Test method (post-emergence stem and leaf spray treatment):

Culturing weeds by a potting method, and uniformly spraying by adopting stem and leaf spraying when the weeds are in a 2-3 leaf period, wherein the spraying amount is 450 kg/hectare.

4) Data investigation and statistical analysis

4.1 Investigation method)

The entire seedlings of surviving weeds were cut off along the soil surface with a blade by an absolute number survey method, and the fresh weight of weeds was weighed with an analytical balance. For weeds that have died, the fresh weight is zero.

4.2 Time and number of surveys

The investigation was performed 15 days after the treatment, 1 total time.

4.3 Data statistics analysis

And (3) evaluating the combined action type of any two and three mixed weeds by using a Colby method.

And (5) shearing green tissues on each treatment ground at 15d, weighing by adopting an electronic balance, and calculating the actual survival rate: e (%) = (fresh weed weight in treated area/fresh weed weight in control area) ×100

The theoretical weed survival rate calculation formula is: e0 (%) =x×y/100 (binary mixture)

Wherein X represents the survival rate of A at P, Y represents the survival rate of B at Q, E0 represents the theoretical survival rate of A+B at (P+Q), and E represents the actual survival rate of each treatment.

E0 (%) =x×y×z× … ×n/100 ^(n-1) (ternary or higher mixture)

Wherein X, Y, Z, N respectively represent the actual survival rate of n single agents, and n is the number of the compound herbicide varieties.

When E0-E >10%, it is shown that a synergistic effect is produced; antagonism is indicated when E0-E < -10%; when E0-E is between.+ -. 10%, this indicates that an additive effect is produced.

The actual control effect and the combined effect evaluation statistical result of each component mixture on weeds are shown in tables 1-2 below.

Table 1A shows ciclopirox, B shows quinclorac and C shows atrazine

Table 2A shows ciclopirox, B shows quinclorac, C shows terbuthylazine

Note that: e (A): measured fresh weight survival of component A treatment at given dose

E (B): measured fresh weight survival of component B treatment at given dose

E (C): measured fresh weight survival of component C treatment at given dose

E (a+b): measured fresh weight survival of binary blends of component A and component B at a given dose

E (a+c): measured fresh weight survival of binary blends of component A and component C at a given dose

E (b+c): measured fresh weight survival of binary blends of component B and component C at a given dose

E (a+b+c): measured fresh weight survival rate for ternary blends of components A, B, C at a given dose

E ₀ (a+b+c): theoretical fresh weight survival rate of ternary blend of components A, B, C at given dose

E ₀ ((a+b) +c): theoretical fresh weight survival of component A, B as a whole binary blend with component C at a given dose

E ₀ ((a+c) +b): theoretical fresh weight survival of component A, C as a whole binary blend with component B at a given dose

E ₀ (a+ (b+c)): theoretical fresh weight survival of component B, C as a whole binary blend with component A at a given dose

C) Demonstration of field

The herbicide compositions prepared in examples 1-2 were used for field weed effect tests. Weeds occurring in the field are mainly: herba Polygoni Tinctorii, hemostatic crabgrass, brown bristlegrass, echinochloa, herba Polygoni Capitati, herba Acalyphae, etc.

The test method comprises the following steps: in the 3-4 leaf stage of weeds, a manual sprayer is used, the water adding amount is 30 kg/667 m ², and stem and leaf spraying is adopted. The specific test agents and dosages are detailed in Table 3. The investigation and control effects 28 days after the application are shown in Table 3.

Exemplary field effects of the formulated compositions described in Table 3

Through a large number of experiments and researches, the composition is unexpectedly found to have a surprising and unexpected synergistic effect for preventing and killing various grassy weeds and broadleaf weeds, the synergistic effect is more remarkable in low dosage, the dosage can be reduced, the pollution to the environment is reduced, the agricultural cost is reduced due to reasonable compounding, the composition is efficient for ALS and ACCase inhibitor resistant weeds, and the composition has a good application prospect. Meanwhile, the test shows that the herbicide composition has good selectivity and excellent synergistic effect in fields such as sorghum, corn and the like, and can be developed into herbicide mixtures with wide market value.

Claims (9)

1. A ternary herbicidal composition comprising ciclopirox and quinclorac, which is characterized by comprising a herbicidally effective amount of an active ingredient A, an active ingredient B and an active ingredient C, wherein,

The active ingredient A is ciclopirox olamine;

the active component B is quinclorac;

the active ingredient C is selected from one of the following compounds: atrazine, terbuthylazine.

2. The ternary herbicidal composition of claim 1 wherein the weight ratio of A, B to C is 1-150:1-500:1-1000, 20-100:50-250:100-800, 30-90:70-200:150-600 or 40-70:80-180:200-400.

3. The ternary herbicidal composition of claim 1, wherein the active ingredient a is ciclopirox, the active ingredient B is quinclorac, the active ingredient C is atrazine, the weight ratio of A, B to C is 20-100:50-250:150-800, preferably 22.5-90:56.25-225:187.5-750; or alternatively

The active component A is ciclopirox, the active component B is quinclorac, the active component C is terbuthylazine, the weight ratio of A, B to C is 20-100:50-250:100-500, and the preferential weight ratio is 22.5-90:56.25-225:112.5-450.

4. A ternary herbicidal composition according to any of claims 1-3, characterized in that the herbicidal composition comprises A, B and C in a mass percentage of 1-95%, preferably 10-80% of the total.

5. A ternary herbicidal composition according to any of claims 1-3, characterized in that it further comprises conventional adjuvants, preferably comprising carriers and/or surfactants.

6. A ternary herbicidal composition according to any of claims 1-3, characterized in that the herbicidal composition further comprises at least one safener, preferably selected from one or more of bisbenzoxazole acid, cyprosulfamide, mequindox, gibberellic acid, furilazole, metcamifen.

7. The ternary herbicidal composition of any one of claims 1-6, wherein the specific formulation of the herbicidal composition is a dispersible oil suspension, an aqueous suspension, a suspoemulsion, a wettable powder, an emulsifiable concentrate, a water dispersible granule, an aqueous emulsion or a microemulsion.

8. Use of a ternary herbicidal composition according to any of claims 1 to 7 for controlling weeds, preferably for selectively controlling weeds in crops of useful plants, more preferably in crops of useful plants which have been treated by transgenic or genomic editing techniques.

9. A method of controlling unwanted vegetation which comprises applying the ternary herbicidal composition of any one of claims 1 to 7 to plants, plant parts, plant seeds or areas of vegetation, preferably the herbicidal composition is used to selectively control weeds in crops of useful plants, more preferably the crops of useful plants are transgenic crops or crops of useful plants which have been treated by genome editing techniques.