CN118104653B - Low-foam low-odor phthalic dicarboxaldehyde disinfectant and preparation method thereof - Google Patents
Low-foam low-odor phthalic dicarboxaldehyde disinfectant and preparation method thereof Download PDFInfo
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- CN118104653B CN118104653B CN202410533803.7A CN202410533803A CN118104653B CN 118104653 B CN118104653 B CN 118104653B CN 202410533803 A CN202410533803 A CN 202410533803A CN 118104653 B CN118104653 B CN 118104653B
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- ZWLUXSQADUDCSB-UHFFFAOYSA-N phthalaldehyde Chemical compound O=CC1=CC=CC=C1C=O ZWLUXSQADUDCSB-UHFFFAOYSA-N 0.000 title claims abstract description 66
- 239000000645 desinfectant Substances 0.000 title claims abstract description 49
- 239000006260 foam Substances 0.000 title claims abstract description 38
- 238000002360 preparation method Methods 0.000 title claims abstract description 10
- 239000002904 solvent Substances 0.000 claims abstract description 14
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 12
- 239000002738 chelating agent Substances 0.000 claims abstract description 11
- 239000002994 raw material Substances 0.000 claims abstract description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 10
- 230000000149 penetrating effect Effects 0.000 claims abstract description 9
- 239000006179 pH buffering agent Substances 0.000 claims abstract description 8
- 239000008213 purified water Substances 0.000 claims abstract description 8
- 239000012747 synergistic agent Substances 0.000 claims abstract description 8
- 150000002500 ions Chemical class 0.000 claims description 11
- 238000003756 stirring Methods 0.000 claims description 11
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims description 8
- 238000002156 mixing Methods 0.000 claims description 8
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 7
- POAOYUHQDCAZBD-UHFFFAOYSA-N 2-butoxyethanol Chemical compound CCCCOCCO POAOYUHQDCAZBD-UHFFFAOYSA-N 0.000 claims description 4
- 239000002202 Polyethylene glycol Substances 0.000 claims description 4
- 235000019437 butane-1,3-diol Nutrition 0.000 claims description 4
- 229920001223 polyethylene glycol Polymers 0.000 claims description 4
- 229960004063 propylene glycol Drugs 0.000 claims description 4
- 239000011734 sodium Substances 0.000 claims description 4
- KSQXVLVXUFHGJQ-UHFFFAOYSA-M Sodium ortho-phenylphenate Chemical compound [Na+].[O-]C1=CC=CC=C1C1=CC=CC=C1 KSQXVLVXUFHGJQ-UHFFFAOYSA-M 0.000 claims description 3
- ABBQHOQBGMUPJH-UHFFFAOYSA-M Sodium salicylate Chemical compound [Na+].OC1=CC=CC=C1C([O-])=O ABBQHOQBGMUPJH-UHFFFAOYSA-M 0.000 claims description 3
- -1 dicarboxymethyl Chemical group 0.000 claims description 3
- OPGYRRGJRBEUFK-UHFFFAOYSA-L disodium;diacetate Chemical compound [Na+].[Na+].CC([O-])=O.CC([O-])=O OPGYRRGJRBEUFK-UHFFFAOYSA-L 0.000 claims description 3
- 238000001914 filtration Methods 0.000 claims description 3
- 239000006174 pH buffer Substances 0.000 claims description 3
- 239000002245 particle Substances 0.000 claims description 3
- 229940051841 polyoxyethylene ether Drugs 0.000 claims description 3
- 229920000056 polyoxyethylene ether Polymers 0.000 claims description 3
- 239000001632 sodium acetate Substances 0.000 claims description 3
- 235000017454 sodium diacetate Nutrition 0.000 claims description 3
- 235000010294 sodium orthophenyl phenol Nutrition 0.000 claims description 3
- 229960004025 sodium salicylate Drugs 0.000 claims description 3
- AXTGDCSMTYGJND-UHFFFAOYSA-N 1-dodecylazepan-2-one Chemical compound CCCCCCCCCCCCN1CCCCCC1=O AXTGDCSMTYGJND-UHFFFAOYSA-N 0.000 claims description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims description 2
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims description 2
- QILXPCHTWXAUHE-UHFFFAOYSA-N [Na].NCCN Chemical compound [Na].NCCN QILXPCHTWXAUHE-UHFFFAOYSA-N 0.000 claims description 2
- 235000004279 alanine Nutrition 0.000 claims description 2
- 239000000872 buffer Substances 0.000 claims description 2
- 150000007942 carboxylates Chemical class 0.000 claims description 2
- 239000008363 phosphate buffer Substances 0.000 claims description 2
- 230000001105 regulatory effect Effects 0.000 claims description 2
- 229910052708 sodium Inorganic materials 0.000 claims description 2
- SOBHUZYZLFQYFK-UHFFFAOYSA-K trisodium;hydroxy-[[phosphonatomethyl(phosphonomethyl)amino]methyl]phosphinate Chemical compound [Na+].[Na+].[Na+].OP(O)(=O)CN(CP(O)([O-])=O)CP([O-])([O-])=O SOBHUZYZLFQYFK-UHFFFAOYSA-K 0.000 claims description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 21
- 230000002147 killing effect Effects 0.000 abstract description 9
- 238000000034 method Methods 0.000 abstract description 7
- 230000008569 process Effects 0.000 abstract description 5
- 238000004140 cleaning Methods 0.000 abstract description 4
- 238000002791 soaking Methods 0.000 abstract description 4
- 210000004666 bacterial spore Anatomy 0.000 abstract description 3
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 2
- 230000000249 desinfective effect Effects 0.000 abstract description 2
- 239000007921 spray Substances 0.000 abstract description 2
- 230000000052 comparative effect Effects 0.000 description 19
- 230000000694 effects Effects 0.000 description 11
- 230000001954 sterilising effect Effects 0.000 description 10
- 238000012360 testing method Methods 0.000 description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 7
- 230000001580 bacterial effect Effects 0.000 description 6
- 244000005700 microbiome Species 0.000 description 5
- 210000004215 spore Anatomy 0.000 description 5
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 3
- ZNZYKNKBJPZETN-WELNAUFTSA-N Dialdehyde 11678 Chemical compound N1C2=CC=CC=C2C2=C1[C@H](C[C@H](/C(=C/O)C(=O)OC)[C@@H](C=C)C=O)NCC2 ZNZYKNKBJPZETN-WELNAUFTSA-N 0.000 description 3
- 238000004090 dissolution Methods 0.000 description 3
- 239000004094 surface-active agent Substances 0.000 description 3
- OHOTVSOGTVKXEL-UHFFFAOYSA-K trisodium;2-[bis(carboxylatomethyl)amino]propanoate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)C(C)N(CC([O-])=O)CC([O-])=O OHOTVSOGTVKXEL-UHFFFAOYSA-K 0.000 description 3
- 101100345345 Arabidopsis thaliana MGD1 gene Proteins 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- 210000002421 cell wall Anatomy 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 235000019441 ethanol Nutrition 0.000 description 2
- 229910021645 metal ion Inorganic materials 0.000 description 2
- 230000000813 microbial effect Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000006386 neutralization reaction Methods 0.000 description 2
- 229940054441 o-phthalaldehyde Drugs 0.000 description 2
- 230000035699 permeability Effects 0.000 description 2
- 238000013112 stability test Methods 0.000 description 2
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 description 1
- 244000063299 Bacillus subtilis Species 0.000 description 1
- 235000014469 Bacillus subtilis Nutrition 0.000 description 1
- 206010011409 Cross infection Diseases 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 241000186359 Mycobacterium Species 0.000 description 1
- 241000187479 Mycobacterium tuberculosis Species 0.000 description 1
- 206010029803 Nosocomial infection Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229960000686 benzalkonium chloride Drugs 0.000 description 1
- XIWFQDBQMCDYJT-UHFFFAOYSA-M benzyl-dimethyl-tridecylazanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 XIWFQDBQMCDYJT-UHFFFAOYSA-M 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 239000006184 cosolvent Substances 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 150000002191 fatty alcohols Chemical class 0.000 description 1
- 238000005187 foaming Methods 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 238000006552 photochemical reaction Methods 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 235000013772 propylene glycol Nutrition 0.000 description 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 229940117565 trisodium dicarboxymethyl alaninate Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/36—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids
- A01N37/38—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids having at least one oxygen or sulfur atom attached to an aromatic ring system
- A01N37/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids having at least one oxygen or sulfur atom attached to an aromatic ring system having at least one carboxylic group or a thio analogue, or a derivative thereof, and one oxygen or sulfur atom attached to the same aromatic ring system
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/22—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing ingredients stabilising the active ingredients
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/08—Oxygen or sulfur directly attached to an aromatic ring system
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N35/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical
- A01N35/04—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical containing aldehyde or keto groups, or thio analogues thereof, directly attached to an aromatic ring system, e.g. acetophenone; Derivatives thereof, e.g. acetals
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/02—Saturated carboxylic acids or thio analogues thereof; Derivatives thereof
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- A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
- A01P1/00—Disinfectants; Antimicrobial compounds or mixtures thereof
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Abstract
The invention belongs to the technical field of antibacterial disinfection, and particularly discloses a low-foam low-odor phthalic dicarboxaldehyde disinfectant and a preparation method thereof, wherein the disinfectant is prepared from the following raw materials in percentage by weight: 0.5-0.6% of phthalic aldehyde, 0.05-0.5% of synergistic agent, 0.2-0.5% of ion chelating agent, 1-3% of penetrating agent, 5-10% of solubilizer, 0.1-0.5% of pH buffering agent and 100% of purified water. The low-foam low-odor phthalic aldehyde disinfectant provided by the invention can be used for disinfecting soft endoscopes and medical instruments, and has good killing effect on mycobacteria and bacterial spores; the foamability is low, so that the disinfection process is visualized, the risk of cutting the staff by the instrument during cleaning can be reduced, and the spray soaking disinfection can be satisfied.
Description
Technical Field
The invention relates to a low-foam low-odor phthalic aldehyde disinfectant and a preparation method thereof, belonging to the technical field of antibacterial disinfection.
Background
Medical instruments such as soft endoscopes are repeatedly used, and strict cleaning, disinfection and sterilization are required after the use is completed in order to avoid cross infection. Because the soft endoscope has precise structure and special material, most of the soft endoscopes are not resistant to high temperature and high pressure, a low-temperature chemical disinfection method is generally adopted, and glutaraldehyde and phthalic aldehyde (OPA) are common disinfection solutions for the soft endoscope at present. The phthalaldehyde has strong killing effect on bacterial propagules, fungi, mycobacteria, viruses, bacterial spores and even certain parasites, and particularly has good killing effect on glutaraldehyde-resistant mycobacterium tuberculosis. Meanwhile, the phthalic aldehyde has the advantages of low use concentration, short sterilization time, low toxicity, low volatility, good object friendliness and the like, and overcomes the defects of glutaraldehyde in the aspects of irritation, toxicity, stability and the like. The phthalic dicarboxaldehyde has good stability in the pH range of 3-9, and the solution can be continuously used for 14 days.
The phthalic dicarboxaldehyde disinfectant on the market at present has the following defects:
(1) In order to ensure the sterilization effect, a surfactant is usually added into the disinfectant to serve as a penetrating agent, but the foamability of the surfactant commonly used at present ensures that foam is accumulated when the disinfectant is used, and the sterilization effect of the disinfectant is affected. During cleaning, accumulated foam also shields the vision of the staff, and the risk that the staff is cut by the instrument is increased. Therefore, some manufacturers choose to add the defoaming and foam suppressing agent to reduce the foaming condition of the surfactant, but find that the defoaming and foam suppressing agent has limited actual foam suppressing capability in the system in the application process, or is incompatible with the system, and the phenomenon of separating out the defoaming and foam suppressing agent can occur after long-time placement.
(2) When absolute ethyl alcohol is used as a solvent, the phthalic dicarboxaldehyde disinfectant is easy to volatilize, so that the system is unstable, and the solute is easy to separate out.
(3) The phthalaldehyde is easily interfered and influenced by various metal ions existing in a solution medium, and an unstable phenomenon is generated.
(4) Although the smell of the phthalic aldehyde is much reduced compared with that of glutaraldehyde, the phthalic aldehyde is sensitive to light and air and can volatilize along with water vapor, so that the phthalic aldehyde still has a certain pungent smell in the use process of the product, and the clinical use is influenced.
The foregoing is not necessarily a prior art, and falls within the technical scope of the inventors.
Disclosure of Invention
The invention aims to solve the problems in the prior art, provides a low-foam low-odor phthalic aldehyde disinfectant and a preparation method thereof, simultaneously ensures high solubility and stability of phthalic aldehyde, enhances the permeability of the phthalic aldehyde to the microbial cell wall, increases the exposure degree of the phthalic aldehyde active group dialdehyde, and improves the effect of the disinfectant on killing microorganisms.
A low-foam low-odor phthalic aldehyde disinfectant is prepared from the following raw materials in percentage by weight: 0.5 to 0.6 percent of phthalic aldehyde, 0.05 to 0.5 percent of synergistic agent, 0.2 to 0.5 percent of ion chelating agent, 1 to 3 percent of penetrating agent, 5 to 10 percent of solubilizer, 0.1 to 0.5 percent of pH buffering agent and 100 percent of purified water;
the synergistic agent consists of sodium salicylate, sodium o-phenylphenol and sodium diacetate in a weight ratio of 3:3:1;
the ion chelating agent consists of (1-5) 5 of trisodium dicarboxymethyl alanine (MGDA) and sodium ethylenediamine diphthalic acetate (EDDHA-Na) in weight ratio;
the penetrating agent consists of polyethylene glycol (PEG-400), sodium fatty alcohol polyoxyethylene ether carboxylate (AEC-9 Na) and water-soluble azone in a weight ratio of 5:3:2;
The pH value of the low-foam low-odor phthalic aldehyde disinfectant is 7-9, and the sum of the weight percentages of the rest raw materials except the pH buffering agent and the purified water is not less than 10%.
Optionally, the solubilizer consists of any one or two of 1, 2-propylene glycol and 1, 3-butanediol and ethylene glycol monobutyl ether in a weight ratio of 1:1.
Optionally, the pH buffer is any one or two of phosphate buffer and carbonate buffer with pH value of 9.0-10.0.
The preparation method of the low-foam low-odor phthalic aldehyde disinfectant provided by the invention comprises the following steps:
(1) At normal temperature, adding phthalic dicarboxaldehyde into the solubilizer, and stirring and dissolving until no obvious phthalic dicarboxaldehyde particles exist;
(2) Adding purified water, and stirring and mixing uniformly;
(3) Filtering to obtain a clear solution;
(4) Sequentially adding a penetrating agent, an ion chelating agent and a synergistic agent, and uniformly stirring and mixing the solution after adding one component;
(5) And adding a pH buffering agent, and regulating the pH value of the solution to obtain the low-foam low-odor phthalic dicarboxaldehyde disinfectant.
The beneficial effects of the application include, but are not limited to:
The low-foam low-odor phthalic aldehyde disinfectant provided by the invention can be used for disinfecting soft endoscopes and medical instruments, and has a good killing effect on mycobacterium and bacterial spores.
Specifically, (1) the low-foam low-odor phthalic aldehyde disinfectant provided by the invention has low foamability, so that the disinfection process is visualized, the risk of cutting a worker by an instrument during cleaning can be reduced, and the spray soaking disinfection can be satisfied.
(2) The low-foam low-odor phthalic aldehyde disinfectant provided by the invention adopts 1, 2-propylene glycol, 1, 3-butanediol and ethylene glycol monobutyl ether as solubilizers, establishes a solvent system of alcohol-water-organic solvent, enhances the solubility of phthalic aldehyde in normal temperature environment, can form a solution with good dispersibility, enhances the permeability of phthalic aldehyde to microbial cell walls and improves the effect of killing microorganisms.
(4) The low-foam low-odor phthalic aldehyde disinfectant provided by the invention adopts the cosolvent 1, 2-propanediol, 1, 3-butanediol and ethylene glycol monobutyl ether, can increase the exposure degree of phthalic aldehyde active group dialdehyde, enhances the electrostatic attraction between the phthalic aldehyde active group dialdehyde and the external cells of a microorganism organism, is tightly combined with the microorganism, reduces and interferes the normal life activities in the microorganism, reduces the biological activity until death, and achieves the aim of high-level disinfection and sterilization.
(5) According to the low-foam low-odor phthalic aldehyde disinfectant provided by the invention, the ion chelating agent is added into the solution system to complex with interfering ions in the solution, so that the absorption and photochemical reaction of phthalic aldehyde and metal ions are prevented, and the solubility of the phthalic aldehyde in the system is enhanced by matching with the solubilizer, so that the phthalic aldehyde solution is more stable, the volatilization of phthalic aldehyde molecules is reduced, and the purpose of odor reduction is achieved.
Drawings
The accompanying drawings, which are included to provide a further understanding of the application and are incorporated in and constitute a part of this specification, illustrate embodiments of the application and together with the description serve to explain the application and do not constitute a limitation on the application. In the drawings:
fig. 1 shows the 90min spore killing effect of examples 1 to 4, and the pictures of reference numerals (1) to (4) correspond to examples 1 to 4, respectively.
FIG. 2 shows the 90min spore killing effect of comparative examples 1 to 5, and the pictures numbered (1) to (5) correspond to comparative examples 1 to 5, respectively.
Detailed Description
The present invention will be described in further detail in the following. It should be noted, however, that the following detailed description presents specific examples of the invention by way of illustration only, and the scope of the invention is not limited thereto. The scope of the invention is limited only by the claims. It will be obvious to those skilled in the art that various other modifications and substitutions can be made to the described embodiments of the invention within the scope of the invention as defined by the appended claims, and the same technical effects can still be achieved, achieving the final technical purpose of the invention.
Unless otherwise indicated, the starting materials in this specification are commercially available.
Example 1:
the low-foam low-odor phthalic aldehyde disinfectant provided in this example is prepared from the raw materials in table 1:
The preparation method of the low-foam low-odor phthalic dicarboxaldehyde disinfectant provided by the embodiment comprises the following steps:
(1) In a normal temperature environment, adding phthalic dicarboxaldehyde into the solubilizer, stirring for 30 min-1 h, and dissolving until no obvious phthalic dicarboxaldehyde particles exist;
(2) Adding purified water into the solution obtained in the step (1), stirring for 10min, and uniformly mixing;
(3) Filtering the solution obtained in the step (2) through an activated carbon filter and a 0.45 mu m filter membrane to obtain a clear solution;
(4) Sequentially adding a penetrating agent, an ion chelating agent and a synergistic agent into the solution obtained in the step (3), and stirring for 10min to fully mix;
(5) And (3) measuring the pH value of the solution obtained in the step (4), adding a pH buffering agent according to the measured pH value, and stirring and mixing fully to obtain the low-foam low-odor phthalic dicarboxaldehyde disinfectant.
Example 2:
The low-foam low-odor phthalic aldehyde disinfectant provided in this example is prepared from the raw materials in table 2:
the preparation method of the low-foam low-odor phthalic aldehyde disinfectant provided by the embodiment is the same as that of the embodiment 1.
Example 3:
The low-foam low-odor phthalic aldehyde disinfectant provided in this example is prepared from the raw materials in table 3:
the preparation method of the low-foam low-odor phthalic aldehyde disinfectant provided by the embodiment is the same as that of the embodiment 1.
Example 4:
the low-foam low-odor phthalic aldehyde disinfectant provided in this example is prepared from the raw materials in table 4:
comparative example 1:
This comparative example differs from example 1 in that: the synergist is replaced by quaternary ammonium salt (benzalkonium chloride) with the same weight, and more foam is accumulated on the surface of the prepared disinfectant.
Comparative example 2:
This comparative example differs from example 1 in that: the penetrant is replaced by polyethylene glycol or fatty alcohol polyoxyethylene ether AEO with the same weight, and more foam is accumulated on the surface of the prepared disinfectant.
Comparative example 3:
this comparative example differs from example 1 in that: the solubilizing agent was replaced with an equivalent weight of ethanol. The results show that the dissolution rate of the phthalic aldehyde is not greatly different from that of the example 1, but the prepared disinfectant has strong phthalic aldehyde smell due to the high volatility of the ethanol.
Comparative example 4:
this comparative example differs from example 1 in that: the ion chelating agent was replaced with 0.15kg of trisodium dicarboxymethyl alaninate (MGDA).
Comparative example 5:
This comparative example differs from example 1 in that: the amount of pH buffer used was 0.
Comparative example 6:
This comparative example differs from example 1 in that: adding the raw materials into a container, and uniformly stirring. The result shows that the o-phthalaldehyde has low dissolution rate and insufficient dissolution, and the uniform and stable low-foam low-odor o-phthalaldehyde disinfectant cannot be prepared.
The detection method and detection result of the use effect of the phthalic aldehyde disinfectant provided in each example and comparative example are as follows.
1. Stability test
The disinfectant provided in each example and comparative example of the present invention was placed in an oven at 37 ℃ for 90 days, and the content of the active ingredients of each group of samples before and after the placement was measured, and the stability test results are shown in table 5.
2. Sterilization test (Bacillus subtilis black variant spore carrier soaking quantitative sterilization test)
The experimental method comprises the following steps: tests were carried out according to methods 2.1.1.5.6 and 2.1.1.7.5 of the Ministry of health, disinfection Specification (2002 edition).
Disinfectant solutions of the corresponding concentrations were aspirated into the dishes in an amount of 5.0ml per tablet. Placing the disinfectant-containing plate in a water bath box at 20+/-1 ℃ for 5min, respectively placing 3 prepared bacterial slices into sterile forceps, and soaking the bacterial slices in a disinfectant. After the bacteria interact for a predetermined time, the bacterial pieces are taken out by sterile forceps and transferred into a test tube containing 5.0ml of neutralizer. Mixing for 20s with electric mixer, or vibrating the test tube on palm for 80 times to elute bacteria on the bacterial sheet into the neutralization solution, and standing for more than 5min to make neutralization effect sufficient. After final further mixing, 1.0ml of direct inoculation dishes were pipetted, 2 dishes were inoculated per tube, and viable bacteria count was determined.
Another plate was taken, 10.0ml of the diluent was injected instead of the disinfectant, and 2 bacterial pieces were put in as a positive control group. The subsequent test steps are the same as those of the above test group. All test specimens were incubated in a 37℃incubator for 72h to observe the final results.
The test was repeated 3 times, and the results of each of the examples and comparative examples are shown in tables 6 and 7.
As shown in fig. 1 and 2, the killing conditions of the examples and the comparative examples show that the use effect of the comparative examples is significantly inferior to that of the examples of the present invention.
The low-foam low-odor phthalic aldehyde disinfectant provided by the invention adopts sodium salicylate, sodium o-phenylphenol and sodium diacetate as synergists, and has an auxiliary sterilization effect when being compounded with phthalic aldehyde, so that the sterilization effect of the disinfectant on spores is enhanced; the ion chelating agent is added to be matched with the solubilizer, so that the solubility and stability of the disinfectant are improved, and the odor emission is reduced; the penetrant is added to assist the disinfectant to permeate into the spore cells, so that the sterilization process is faster and more effective.
The above embodiments are not to be taken as limiting the scope of the invention, and any alternatives or modifications to the embodiments of the invention will be apparent to those skilled in the art and fall within the scope of the invention.
The present invention is not described in detail in the present application, and is well known to those skilled in the art.
Claims (2)
1. The low-foam low-odor phthalic aldehyde disinfectant is characterized by being prepared from the following raw materials in percentage by weight: 0.5 to 0.6 percent of phthalic aldehyde, 0.05 to 0.5 percent of synergistic agent, 0.2 to 0.5 percent of ion chelating agent, 1 to 3 percent of penetrating agent, 5 to 10 percent of solubilizer, 0.1 to 0.5 percent of pH buffering agent and 100 percent of purified water;
the synergistic agent consists of sodium salicylate, sodium o-phenylphenol and sodium diacetate in a weight ratio of 3:3:1;
The ion chelating agent consists of trisodium dicarboxymethyl alanine and sodium ethylenediamine diphthalic acetate in a weight ratio of (1-5): 5;
the penetrating agent consists of polyethylene glycol, sodium fatty alcohol-polyoxyethylene ether carboxylate and water-soluble azone in a weight ratio of 5:3:2;
The solubilizer consists of any one or two of 1, 2-propylene glycol and 1, 3-butanediol and ethylene glycol monobutyl ether in a weight ratio of 1:1;
the pH value of the low-foam low-odor phthalic aldehyde disinfectant is 7-9, and the sum of the weight percentages of the rest raw materials except the pH buffering agent and the purified water is not less than 10%;
The preparation method of the low-foam low-odor phthalic aldehyde disinfectant comprises the following steps:
(1) At normal temperature, adding phthalic dicarboxaldehyde into the solubilizer, and stirring and dissolving until no obvious phthalic dicarboxaldehyde particles exist;
(2) Adding purified water, and stirring and mixing uniformly;
(3) Filtering to obtain a clear solution;
(4) Sequentially adding a penetrating agent, an ion chelating agent and a synergistic agent, and uniformly stirring and mixing the solution after adding one component; (5) And adding a pH buffering agent, and regulating the pH value of the solution to obtain the low-foam low-odor phthalic dicarboxaldehyde disinfectant.
2. The low-foam low-odor phthalic aldehyde disinfectant according to claim 1, wherein the pH buffer is any one or two of phosphate buffer and carbonate buffer with pH value of 9.0-10.0.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101785460A (en) * | 2009-01-23 | 2010-07-28 | 上海利康消毒高科技有限公司 | O-phthalaldehyde disinfectant and preparation method thereof |
| CN104621104A (en) * | 2015-02-02 | 2015-05-20 | 山东威高药业股份有限公司 | Disinfectant with low corrosiveness |
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| JP2665320B2 (en) * | 1994-12-06 | 1997-10-22 | アクアス株式会社 | Circulating water microorganism control agent for heat exchange and circulating water microorganism control method for heat exchange |
| CN105379712A (en) * | 2015-12-15 | 2016-03-09 | 山东消博士消毒科技股份有限公司 | Phthalic dicarboxaldehyde disinfectant for endoscope cleaning and preparation technology thereof |
| CN107711835A (en) * | 2017-11-07 | 2018-02-23 | 济南市利东医疗设备有限公司 | A kind of O-phthalaldehyde disinfectant and preparation method thereof |
| CN112244020A (en) * | 2020-09-16 | 2021-01-22 | 山东利尔康医疗科技股份有限公司 | Low-foam low-odor phthalic dicarboxaldehyde formula and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101785460A (en) * | 2009-01-23 | 2010-07-28 | 上海利康消毒高科技有限公司 | O-phthalaldehyde disinfectant and preparation method thereof |
| CN104621104A (en) * | 2015-02-02 | 2015-05-20 | 山东威高药业股份有限公司 | Disinfectant with low corrosiveness |
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