CN1180852C - Local medicine-applying system and its preparing process and equipment - Google Patents
Local medicine-applying system and its preparing process and equipment Download PDFInfo
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- CN1180852C CN1180852C CNB011073047A CN01107304A CN1180852C CN 1180852 C CN1180852 C CN 1180852C CN B011073047 A CNB011073047 A CN B011073047A CN 01107304 A CN01107304 A CN 01107304A CN 1180852 C CN1180852 C CN 1180852C
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Abstract
The present invention discloses a local administration system, a preparing method thereof and a device thereof. The local administration system is composed of a cupping glass and medicine in the cupping glass, wherein the medicine in the cupping glass has the effects of activating blood circulation and dispelling pain. The medicine comprises: 9 to 14 parts by weight of notoginseng, 7 to 12 parts by weight of hemlock parsley, 7 to 12 parts by weight of epimedium herb, 5 to 8 parts by weight of desertliving cistanche, 5 to 8 parts by weight of dragon blood, 5 to 8 parts by weight of safflower, 1 to 5 parts by weight of centipede, 2 to 5 parts by weight of dried ginger, and 61 to 108 parts by weight of edible distillate spirit.
Description
The present invention relates to a kind of local drug delivery device, belong to the medical apparatus technical field.
In the daily life, Itai-itai diseases, cervical spondylosis, hyperosteogeny, arthritis, spondylitis, scapulohumeral periarthritis, neuralgia, traumatic injury etc. are common diseases.The disease serious harm humans of this class healthy, pain unbearably.Have also can cause the paralysis, patient is very painful.But existing topical dosage form, for example: adhesive plaster with medicine, emulsifiable paste or spray etc. can only make the disease respite, cure the symptoms, not the disease.The cervical spondylopathy patient that has has to adopt medical apparatus such as traction grade, and patient endures torture and do not say, seeking medical advice in effect patient four directions also undesirable, that have, has spent thousands of medical care expenses, still do not cure, even lose confidence, pessimism.
Cupping is the therapeutic appliance of motherland's traditional medicine, but existing cupping all is the canister with a sky, is attached to after the heating on people's the skin, utilizes the suction function in the canister to promote local blood circulation.So far as yet not relevant for the document announcement that cupping is combined with the Chinese medicine Drug therapy.The therapeutic effect of cupping also has significant limitation.
The purpose of this invention is to provide a kind of brand-new local drug delivery device, use this device can promote the infiltration and the absorption of medicine effectively, have the good active pain effect of dispelling, thereby numerous patients is got well.
The object of the present invention is achieved like this:
Local drug delivery device of the present invention, by cupping and be contained in the cupping have active dispel the pain effect medicine constitute.
Medicine of the present invention is made by following component (parts by weight):
Radix Notoginseng 9-14, Rhizoma Chuanxiong 7-12, Herba Epimedii 7-12, Herba Cistanches 5-8, Sanguis Draxonis 5-8, Flos Carthami 5-8, Scolopendra 1-5, Rhizoma Zingiberis 2-5, edible distillate spirit 61-108.
Medicine of the present invention prepares according to following steps:
1. the medicine that will have the active pain effect of dispelling, drying and crushing to 40 order fine powder mixing;
With edible distillate spirit with the fine drug powder exudation and moistening, be heated to 45-55 ℃;
3. put into cupping, get final product.
In order to implement preparation method of the present invention, the present invention has designed special-purpose cupping, this cupping is a hollow body that injection moulding is as a whole, container comprises tank bottoms, jar waist and jar mouth, tank bottoms longitudinal section is a semi circular surface, and the longitudinal section of jar waist is symmetrical circular-arc for the container center lines being axle, and the longitudinal section of jar mouth is for the container center lines being the symmetrical rectangle of axle.The material of cupping adopts natural rubber or non-toxic plastic.
Compared with prior art, the present invention has following outstanding advantage:
1, the present invention engages Drug therapy dexterously with cupping first and is one, has created a kind of brand-new local medicine-applying system, has obtained beat all technique effect.During use, under the effect of the edible distillate spirit that is heated, the pore diastole of affected part, circulation is accelerated, and adds the effect of cupping, has effectively promoted the infiltration and the absorption of medicine.Trace back and originally ask the source, treating both the principal and the secondary aspects of a disease at the same time.Thereby can cure multiple difficult and complicated illness such as Itai-itai diseases, cervical spondylosis, hyperosteogeny, arthritis, spondylitis, scapulohumeral periarthritis, neuralgia, traumatic injury.
2, Therapeutic Method is simple, and is easy to operate, patient's no pain.The shape of cupping has been done well-designed, a jar waist is that circular-arc, built-in medicine can not drop.Tank bottoms and traditional cupping is all inequality, is a spherosome.During use, can be given treatment to a patient by the doctor, patient also can treat voluntarily, as long as with the hands spherosome of pinching cupping lightly.
What 3, the present invention used all is some Chinese crude drugs commonly used, and raw material sources are extensive, and are with low cost, can reduce patient's medical expense greatly, have the wide development application prospect.
The sketch map of the special-purpose cupping longitudinal section that Fig. 1 designs for the present invention.
As shown in Figure 1, special-purpose cupping 1 is the container that adopts the natural rubber casting, comprise tank bottoms 2, jar waist 3 and jar mouth 4, tank bottoms 2 longitudinal section is semicircle, the longitudinal section of jar waist 3 is for the container center lines being the symmetrical circular arc of axle, and the longitudinal section of jar mouth 4 is to be the symmetrical rectangle of axle with the container center lines.The active medicine of dispelling the pain effect that has of preparation of the present invention just is placed in tank bottoms 2.
To further illustrate the present invention in following embodiment, these embodiment only are used to the present invention is described and to the present invention without limits.
Embodiment 1
With Radix Notoginseng 11 grams, Rhizoma Chuanxiong 9 grams, Herba Epimedii 9 grams, Herba Cistanches 6 grams, Sanguis Draxonis 6 grams, Flos Carthami 6 grams, Scolopendra 3, Rhizoma Zingiberis 3 grams, levigation is crossed 40 mesh sieves, mixing, packing promptly gets a kind of active pain-relieving powder.Get described 20 gram medicated powder and convert 30 milliliters of edible distillate spirits, be heated to 50 ℃, put into the glue jar that puts a chimney on the stove and make the fire draw, promptly make a local medicine-applying system of the present invention.
Embodiment 2
The local medicine-applying system of checking embodiment is to the rabbit skin irritation, and observation experiment animal complete sum damaged skin contact is tried the local irritant effect and the recovery situation thereof that are produced behind the thing.
1. material and method: with the local medicine-applying system cup of embodiment 1,
2. laboratory animal: white rabbit, body weight 2-2.5kg is provided by unming Medical College's Experimental Animal Center.
3. select for use healthy white family to exempt from 4, body weight 2-2.5kg, female, male half and half.Coating cut off animal spinal column both sides in preceding 24 hours by hair, and the about 12.5 * 12.5cm of area checks that the skin of unhairing not damaged can begin test.With the cropping left side is intact tuerculoderma district, and degree of being scratches skin to right side sterilization skin with the oozing of blood with No. 7 syringe needles, is the damaged skin trial zone.With a left side, right both sides
It is as follows that skin is divided into 1,2,3,4 districts:
The right side, left side
| 1 | 2 |
| 3 | 4 |
1,2 districts are the check plot, are coated with the edible wine 1.0ml of 50～C, and 3,4 districts are the trial zone, be coated with 1.0g embodiment 1 active pain-relieving powder respectively, with edible wine absorbent gauze is soaked behind the coating and apply, use immobilization with adhesive tape, put into fixedly cage at the coating position, 1 in every cage, with warm water medicine is cleaned after 6 hours, perusal every day coating local skin has or not erythema, irritant reaction such as edema, every day coating once, a continuous week.Continue after the drug withdrawal to observe 7 days, the execution animal is got the coating local skin and carries out histopathologic examination again.And by the table 1-2 evaluation of giving a mark.
Table 1 skin irritation reaction standards of grading
The irritant reaction score value
Erythema:
No erythema 0
Very light erythema 1
Sharply marginated erythema (light red-scarlet) 2
Medium serious erythema (scarlet-dark red) 3
There is the slight eschar of erythema to occur 4
Edema:
No edema 0
Very slight edema 1
Mild edema (edge obviously exceeds epidermis) 2
Intermediate edema (exceeding epidermis 1mm) 3
Serious edema (exceeding more than the epidermis 1mm) 4
Table 2. skin irritation degree evaluation standard
Mean scores is estimated
0.0-0.49 nonirritant
0.5-2.99 slight zest
3.0-5.99 moderate zest
6.0-8.0 strong and stimulating
The active Eradicates of table 3. looses bitterly to rabbit skin irritant reaction intensity
Animal irritant reaction mean scores is estimated
10 is non-stimulated
20 is non-stimulated
30 is non-stimulated
40 is non-stimulated
Result of the test shown in the table 3 shows: laboratory animal is smeared active pain-relieving powder, one week of successive administration, observed 7 days continuously after the drug withdrawal, intact skin and damaged skin all find no irritant reaction such as erythema, edema, petechia, pigmentation, and the damaged skin healing is intact.Dermal pathology histological examination result shows: damaged and damaged skin not, and 50 ℃ of edible wine and administration treated animal epidermis are normal, and corium is not seen congenital cellular infiltration, can see hair follicle and structure is normal.The irritant reaction mean scores is 0.According to skin irritation intensity evaluation standard.Point out active pain-relieving powder to ' rabbit skin nonirritant effect.(this test raw data is stored in provincial natural drug pharmacology key lab of unming Medical College)
Embodiment 3
The acute toxicity test of network pain-relieving powder rabbit skin
1. experiment purpose: observe animal intact skin and damaged skin in short-term heavy dose of contact is tried the toxic reaction that thing produces.
2. method:
A. tried thing: active pain-relieving powder, reddish brown toner wood, 50g/ bag 20g/ time, is mixed well with 50 ℃ of edible wine and to be put into the cupping jar cup after heating.Provide by unming Medical College scientific research pilot scale center.Lot number: 200101080
B. laboratory animal: white rabbit, body weight 2.0-2.5kg is provided by unming Medical College's Experimental Animal Center.The animal quality certification: Yun Dongguan: 99002,99003.
C. select for use healthy white family to exempt from 24, body weight 2.0-2.5kg, coating cut off animal spinal column both sides in preceding 24 hours by hair, and the about 12.5 * 12.5cm of area checks that the skin of unhairing not damaged can begin experiment.Wherein degree of being scratches skin to half animal sterilization skin with the oozing of blood with No. 7 syringe needles, is the damaged skin laboratory animal, and second half animal is intact skin.24 animals are divided into four groups, see Table 4:
Table 4. animal grouping situation
Group medicine animal (only) percutaneous drug delivery amount
Matched group sterile distilled water 2 intact 4ml
Matched group sterile distilled water 2 damaged 4ml
Solvent control eats wine 2 intact 4ml
Solvent control eats wine 2 damaged 4ml
The active pain-relieving powder 4 intact 1g of low dose group
The active pain-relieving powder 4 damaged 1g of low dose group
The active pain-relieving powder 4 intact 3g of high dose group
The active pain-relieving powder 4 damaged 3g of high dose group
Medicine is evenly spread upon the depilation district, and every animal control groups is coated with sterile distilled water, and the solvent control group is coated with 50 ℃ of edible wine, and low dose group is coated with 1g and is subjected to the reagent thing, and high dose group is coated with 3g and is subjected to the reagent thing.With edible wine absorbent gauze is soaked spreading medicine position behind the coating, use immobilization with adhesive tape, put into fixedly cage, single cage is raised.With warm water medicine is cleaned after 24 hours.Observed the untoward reaction of animal continuously until the 7th day in 1,24,48,72 hour, write down zoodermic variation every day, and observe breathing, central nervous system, extremity activity, appetite and other poisoning manifestations, should become celestial immediately and the histopathology observation if any death.
3. experimental result: see Table 5
The active pain-relieving powder skin of table 5 acute toxicity result
Group number of animals (only) dosage administration number of times poisoning manifestations dead animal number
Matched group 2 4ml 1 do not see 0
Matched group 2 4ml 1 do not see 0
Solvent control 2 4ml 1 do not see 0
Solvent control 2 4ml 1 do not see 0
Low dose group 4 1g 1 do not see 0
Low dose group 4 1g 1 do not see 0
High dose group 4 3g 1 do not see 0
High dose group 4 3g 1 do not see 0
4. evaluation of result:
During matched group and experimental group were observed in 7 days, the rabbit body weight gain, appetite is normal, does not observe the untoward reaction of breathing, central nervous system's appearance, and the animal ordinary circumstance is good, prompting, described medicine does not produce the acute toxicity effect to rabbit.
Embodiment 4
Be the checking therapeutic effect that the present invention had, the present invention is through the clinical observation of system, and with the local drug delivery device of embodiment 1,50 people do therapeutic test to the cervical vertebra case, carry out the treatment of medicine fire cupping at painful area,
Each treatment 15-20 minute, a twice-daily, a week is a course of treatment.That obtains significant curative effect accounts for 57%, and what better effects was arranged accounts for 41%, and invalid accounts for 2%.Total effective rate reaches 98%.
Embodiment 5
The present invention also adopts the local drug delivery device of embodiment 1, and the patient who is used for the treatment of diseases such as Itai-itai diseases, hyperosteogeny, arthritis, spondylitis, scapulohumeral periarthritis, neuralgia, traumatic injury is totally 156 people, male patient 87 people wherein, female patient 69 people.Obtain beat all therapeutic effect through treating 3 courses of treatment, be subjected to the consistent favorable comment of patient.Cure rate reaches 82%, and the person of being clearly better reaches 17%, and total effective rate reaches 99%.
Claims (4)
1. local drug delivery device is made of cupping and the medicine that is contained in the cupping, it is characterized in that described cupping is the hollow body of an injection molded, that container comprises is tank bottoms, jar waist and jar mouthful; Tank bottoms longitudinal section is a semicircle, and the longitudinal section of jar waist is for the container center lines being the symmetrical circular arc of axle, and the longitudinal section of jar mouth is for the container center lines being the symmetrical rectangle of axle.
2, device according to claim 1, the material that it is characterized in that the hollow body of described injection molded is rubber or non-toxic plastic.
3, device according to claim 1, it is characterized in that described medicine is the medicine with the active pain effect of dispelling, the parts by weight of medicine are: Radix Notoginseng 9-14, Rhizoma Chuanxiong 7-12, Herba Epimedii 7-12, Herba Cistanches 5-8, Sanguis Draxonis 5-8, Flos Carthami 5-8, Scolopendra 1-5, Rhizoma Zingiberis 2-5, edible distillate spirit 61-108.
4, device according to claim 3 is characterized in that the parts by weight of medicine are: Radix Notoginseng 11, Rhizoma Chuanxiong 9, Herba Epimedii 9, Herba Cistanches 6, Sanguis Draxonis 6, Flos Carthami 6, Scolopendra 3, Rhizoma Zingiberis 3, edible distillate spirit 70.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB011073047A CN1180852C (en) | 2001-03-27 | 2001-03-27 | Local medicine-applying system and its preparing process and equipment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB011073047A CN1180852C (en) | 2001-03-27 | 2001-03-27 | Local medicine-applying system and its preparing process and equipment |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1313134A CN1313134A (en) | 2001-09-19 |
| CN1180852C true CN1180852C (en) | 2004-12-22 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB011073047A Expired - Lifetime CN1180852C (en) | 2001-03-27 | 2001-03-27 | Local medicine-applying system and its preparing process and equipment |
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| Country | Link |
|---|---|
| CN (1) | CN1180852C (en) |
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2001
- 2001-03-27 CN CNB011073047A patent/CN1180852C/en not_active Expired - Lifetime
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| Publication number | Publication date |
|---|---|
| CN1313134A (en) | 2001-09-19 |
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