CN118043039A - 用于改善腺相关病毒(aav)递送的方法 - Google Patents
用于改善腺相关病毒(aav)递送的方法 Download PDFInfo
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- CN118043039A CN118043039A CN202280063874.4A CN202280063874A CN118043039A CN 118043039 A CN118043039 A CN 118043039A CN 202280063874 A CN202280063874 A CN 202280063874A CN 118043039 A CN118043039 A CN 118043039A
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- aav
- aavhu
- aavrh
- aav42
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
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- A61K31/075—Ethers or acetals
- A61K31/08—Ethers or acetals acyclic, e.g. paraformaldehyde
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
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- C12Y115/01001—Superoxide dismutase (1.15.1.1)
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- Veterinary Medicine (AREA)
- Public Health (AREA)
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- Physics & Mathematics (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Inorganic Chemistry (AREA)
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- Immunology (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163271487P | 2021-10-25 | 2021-10-25 | |
| US63/271,487 | 2021-10-25 | ||
| PCT/IB2022/060189 WO2023073526A1 (en) | 2021-10-25 | 2022-10-24 | Methods for improving adeno-associated virus (aav) delivery |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN118043039A true CN118043039A (zh) | 2024-05-14 |
Family
ID=84283163
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202280063874.4A Pending CN118043039A (zh) | 2021-10-25 | 2022-10-24 | 用于改善腺相关病毒(aav)递送的方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20250235554A1 (https=) |
| EP (1) | EP4422613A1 (https=) |
| JP (1) | JP2024539123A (https=) |
| CN (1) | CN118043039A (https=) |
| WO (1) | WO2023073526A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN118743768A (zh) * | 2024-06-13 | 2024-10-08 | 浙江大学 | 一种血小板-aav包装复合体及其制备方法和应用 |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPWO2024071362A1 (https=) * | 2022-09-30 | 2024-04-04 | ||
| WO2025101959A1 (en) * | 2023-11-08 | 2025-05-15 | Renbio, Inc. | Plasmid dna constructs for peptide hormone expression |
| WO2025250457A1 (en) * | 2024-05-28 | 2025-12-04 | University Of Rochester | Enhanced brain transduction by gene therapeutics |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5139941A (en) | 1985-10-31 | 1992-08-18 | University Of Florida Research Foundation, Inc. | AAV transduction vectors |
| WO1998033917A1 (en) | 1994-11-14 | 1998-08-06 | The Ludwig Institute For Cancer Research | Vascular endothelial growth factor c (vegf-c) protein and gene, mutants thereof, and uses thereof |
| US6001650A (en) | 1995-08-03 | 1999-12-14 | Avigen, Inc. | High-efficiency wild-type-free AAV helper functions |
| US6410300B1 (en) | 1998-01-12 | 2002-06-25 | The University Of North Carolina At Chapel Hill | Methods and formulations for mediating adeno-associated virus (AAV) attachment and infection and methods for purifying AAV |
| EP1751275B1 (en) | 2004-06-01 | 2017-08-16 | Avigen, Inc. | Compositions and methods to prevent aav vector aggregation |
| SI2548560T1 (sl) | 2005-06-23 | 2015-12-31 | Isis Pharmaceuticals, Inc. | Sestavki in postopki za moduliranje izrezovanja smn2 |
| US9415121B2 (en) | 2008-12-19 | 2016-08-16 | Nationwide Children's Hospital | Delivery of MECP2 polynucleotide using recombinant AAV9 |
| PT3305302T (pt) | 2009-06-17 | 2018-12-14 | Biogen Ma Inc | Composições e métodos de modulação de excisões de smn2 em um sujeito |
| EP2964270A4 (en) * | 2013-02-21 | 2017-03-22 | University Of Rochester | Methods for evaluating brain-wide paravascular pathway for waste clearance function and methods for treating neurodegenerative disorders based thereon |
| LT3702466T (lt) | 2013-08-27 | 2023-02-27 | Research Institute At Nationwide Children's Hospital | Produktai ir būdai, skirti šoninės amiotrofinės sklerozės gydymui |
| US9585971B2 (en) | 2013-09-13 | 2017-03-07 | California Institute Of Technology | Recombinant AAV capsid protein |
| EP3245221A4 (en) | 2015-01-16 | 2018-06-13 | Voyager Therapeutics, Inc. | Central nervous system targeting polynucleotides |
| KR102423442B1 (ko) | 2015-12-11 | 2022-07-20 | 캘리포니아 인스티튜트 오브 테크놀로지 | 아데노-관련 바이러스를 지시하기 위한 타겟팅 펩타이드 |
| MX2020004830A (es) | 2017-11-08 | 2020-11-11 | Avexis Inc | Medios y metodo para preparar vectores virales y usos de los mismos. |
| TW202015742A (zh) | 2018-05-15 | 2020-05-01 | 美商航海家醫療公司 | 投遞腺相關病毒(aav)之組成物和方法 |
| EP3793615A2 (en) | 2018-05-16 | 2021-03-24 | Voyager Therapeutics, Inc. | Directed evolution of aav to improve tropism for cns |
| US20210207167A1 (en) | 2018-05-16 | 2021-07-08 | Voyager Therapeutics, Inc. | Aav serotypes for brain specific payload delivery |
| US20210277418A1 (en) | 2018-08-03 | 2021-09-09 | Voyager Therapeutics, Inc. | Aav variants with enhanced tropism |
| US12311035B2 (en) * | 2018-10-04 | 2025-05-27 | University Of Rochester | Glymphatic delivery by manipulating plasma osmolarity |
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2022
- 2022-10-24 US US18/703,559 patent/US20250235554A1/en active Pending
- 2022-10-24 WO PCT/IB2022/060189 patent/WO2023073526A1/en not_active Ceased
- 2022-10-24 CN CN202280063874.4A patent/CN118043039A/zh active Pending
- 2022-10-24 JP JP2024523575A patent/JP2024539123A/ja active Pending
- 2022-10-24 EP EP22800804.1A patent/EP4422613A1/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN118743768A (zh) * | 2024-06-13 | 2024-10-08 | 浙江大学 | 一种血小板-aav包装复合体及其制备方法和应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2024539123A (ja) | 2024-10-28 |
| EP4422613A1 (en) | 2024-09-04 |
| US20250235554A1 (en) | 2025-07-24 |
| WO2023073526A1 (en) | 2023-05-04 |
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