CN117965408A - 酰基氨基酸的产生 - Google Patents

酰基氨基酸的产生 Download PDF

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Publication number
CN117965408A
CN117965408A CN202311749532.0A CN202311749532A CN117965408A CN 117965408 A CN117965408 A CN 117965408A CN 202311749532 A CN202311749532 A CN 202311749532A CN 117965408 A CN117965408 A CN 117965408A
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CN
China
Prior art keywords
amino acid
acid
acyl
domain
engineered
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202311749532.0A
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English (en)
Chinese (zh)
Inventor
凯文·A·贾雷尔
加布里尔·O·列兹尼克
普拉山特·维什瓦纳特
米歇尔·派恩
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Modular Genetics Inc
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Modular Genetics Inc
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Filing date
Publication date
Application filed by Modular Genetics Inc filed Critical Modular Genetics Inc
Publication of CN117965408A publication Critical patent/CN117965408A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/36—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y603/00—Ligases forming carbon-nitrogen bonds (6.3)
    • C12Y603/02—Acid—amino-acid ligases (peptide synthases)(6.3.2)

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Environmental Sciences (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN202311749532.0A 2013-03-15 2014-03-14 酰基氨基酸的产生 Pending CN117965408A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201361788346P 2013-03-15 2013-03-15
US61/788,346 2013-03-15
CN201480026841.8A CN105531367A (zh) 2013-03-15 2014-03-14 酰基氨基酸的产生
PCT/US2014/029150 WO2014144649A1 (en) 2013-03-15 2014-03-14 Generation of acyl amino acids

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201480026841.8A Division CN105531367A (zh) 2013-03-15 2014-03-14 酰基氨基酸的产生

Publications (1)

Publication Number Publication Date
CN117965408A true CN117965408A (zh) 2024-05-03

Family

ID=51537750

Family Applications (2)

Application Number Title Priority Date Filing Date
CN202311749532.0A Pending CN117965408A (zh) 2013-03-15 2014-03-14 酰基氨基酸的产生
CN201480026841.8A Pending CN105531367A (zh) 2013-03-15 2014-03-14 酰基氨基酸的产生

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201480026841.8A Pending CN105531367A (zh) 2013-03-15 2014-03-14 酰基氨基酸的产生

Country Status (7)

Country Link
US (4) US9970036B2 (https=)
EP (1) EP2970928A4 (https=)
JP (4) JP6741572B2 (https=)
CN (2) CN117965408A (https=)
BR (1) BR112015023453A2 (https=)
CA (1) CA2907229A1 (https=)
WO (1) WO2014144649A1 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6741572B2 (ja) 2013-03-15 2020-08-19 モジュラー ジェネティクス， インコーポレイテッド アシルアミノ酸の生成
EP2843043A1 (en) * 2013-08-27 2015-03-04 Evonik Industries AG A method for producing acyl amino acids
WO2016049484A1 (en) * 2014-09-26 2016-03-31 Dow Agrosciences Llc Chimeric non-ribosomal peptide synthase
US11371066B2 (en) 2015-07-13 2022-06-28 Modular Genetics, Inc. Generation of acyl alcohols
WO2020018853A2 (en) * 2018-07-18 2020-01-23 Modular Genetics, Inc. Generation of acyl amino acids
CN111454338B (zh) * 2019-01-22 2024-10-01 四川复通科技有限公司 塞普霉素前体肽的突变体、其应用及制得的塞普霉素类似物
WO2020181779A1 (zh) * 2019-03-14 2020-09-17 江南大学 一种基于低共熔溶剂的脂氨基酸类化合物的制备方法
CN111575251B (zh) * 2020-05-29 2022-03-11 上海交通大学 一种用于达托霉素生物合成的dptC1突变体的构建
JPWO2022201968A1 (https=) 2021-03-26 2022-09-29
CN114891837B (zh) * 2022-04-26 2023-04-25 青岛普瑞邦生物工程有限公司 一种产虾夷扇贝毒素的海杆菌及虾夷扇贝毒素的制备方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1264712B1 (it) 1993-07-13 1996-10-04 Eniricerche Spa Metodo di sintesi biologica di peptidi
IT1277466B1 (it) 1995-08-09 1997-11-10 Eniricerche Spa Peptide sintetasi ingegnerizzate e loro impiego per la produzione via non-ribosomale di peptidi
WO2002059322A2 (en) 2000-10-17 2002-08-01 Cubist Pharmaceuticlas, Inc. Compositions and methods relating to the daptomycin biosynthetic gene cluster
WO2003014297A2 (en) 2001-08-06 2003-02-20 Cubist Pharmaceuticals, Inc. Compositions and methods relating to the daptomycin biosynthetic gene cluster
IL160169A0 (en) * 2001-08-06 2004-07-25 Cubist Pharm Inc Nucleic acid molecules that encode a daptomycin non-ribosomal peptide synthetase and methods for the production thereof
MXPA05007653A (es) * 2003-01-17 2005-09-30 Danisco Metodo.
JP2005132833A (ja) 2003-10-08 2005-05-26 Ajinomoto Co Inc Ｎ−長鎖アシルグリシン塩の結晶及びその製造方法、並びに、該ｎ−長鎖アシルグリシン塩の結晶を用いた洗浄料組成物
RU2335495C2 (ru) * 2005-06-15 2008-10-10 Общество С Ограниченной Ответственностью "Фарминтерпрайсез" N-ацильные производные аминокислот, их фармацевтически приемлевые соли, фармацевтическая композиция и применение в качестве гиполипидемических средств
WO2008131014A1 (en) * 2007-04-16 2008-10-30 Modular Genetics, Inc. Lipopeptides and lipopeptide synthetases
WO2008131002A2 (en) * 2007-04-16 2008-10-30 Modular Genetics, Inc. Generation of acyl amino acids
US8470883B2 (en) 2010-07-12 2013-06-25 Conopco, Inc. Preservative system and composition based on glycinate and hydroxyethyl sulfonate salt combination
CA2817961C (en) 2010-11-18 2016-01-05 The Procter & Gamble Company Cosmetic compositions based on a n-acyl amino acid compound and hexyldecanol
JP5714359B2 (ja) 2011-02-28 2015-05-07 株式会社マンダム 半固体状洗浄剤
US8822711B2 (en) 2011-07-28 2014-09-02 Conopco, Inc. Method for preparing fatty acyl amido carboxylic acid based surfactants
JP6741572B2 (ja) 2013-03-15 2020-08-19 モジュラー ジェネティクス， インコーポレイテッド アシルアミノ酸の生成

Also Published As

Publication number Publication date
EP2970928A1 (en) 2016-01-20
JP2023053308A (ja) 2023-04-12
US9970036B2 (en) 2018-05-15
JP2021052771A (ja) 2021-04-08
EP2970928A4 (en) 2017-02-15
JP2020000247A (ja) 2020-01-09
WO2014144649A1 (en) 2014-09-18
US10640799B2 (en) 2020-05-05
CA2907229A1 (en) 2014-09-18
CN105531367A (zh) 2016-04-27
US12031167B2 (en) 2024-07-09
US20210062234A1 (en) 2021-03-04
JP6803434B2 (ja) 2020-12-23
BR112015023453A2 (pt) 2017-12-05
US20180340198A1 (en) 2018-11-29
JP2016512692A (ja) 2016-05-09
JP7432489B2 (ja) 2024-02-16
US20160076065A1 (en) 2016-03-17
JP6741572B2 (ja) 2020-08-19
US11155843B2 (en) 2021-10-26
US20220259626A1 (en) 2022-08-18

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