CN1179646C - Aggregation-preventing nano broad spectrum antibacterial silver powder and its inductrial production process - Google Patents

Aggregation-preventing nano broad spectrum antibacterial silver powder and its inductrial production process Download PDF

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CN1179646C
CN1179646C CN 01110767 CN01110767A CN1179646C CN 1179646 C CN1179646 C CN 1179646C CN 01110767 CN01110767 CN 01110767 CN 01110767 A CN01110767 A CN 01110767A CN 1179646 C CN1179646 C CN 1179646C
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silver
agglomeration
anti
powder
production process
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CN1322474A (en )
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朱红军
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朱红军
朱骊
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L2/00Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/16Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
    • A61L2/23Solid substances, e.g. granules, powders, blocks, tablets
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L2/00Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/16Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
    • A61L2/23Solid substances, e.g. granules, powders, blocks, tablets
    • A61L2/238Metals or alloys, e.g. oligodynamic metals
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B22CASTING; POWDER METALLURGY
    • B22FWORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER
    • B22F1/00Special treatment of metallic powder, e.g. to facilitate working, to improve properties; Metallic powders per se, e.g. mixtures of particles of different composition
    • B22F1/0003Metallic powders per se; Mixtures of metallic powders; Metallic powders mixed with a lubricating or binding agent
    • B22F1/0007Metallic powder characterised by its shape or structure, e.g. fibre structure
    • B22F1/0011Metallic powder characterised by size or surface area only
    • B22F1/0018Nanometer sized particles
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B22CASTING; POWDER METALLURGY
    • B22FWORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER
    • B22F9/00Making metallic powder or suspensions thereof
    • B22F9/16Making metallic powder or suspensions thereof using chemical processes
    • B22F9/18Making metallic powder or suspensions thereof using chemical processes with reduction of metal compounds
    • B22F9/24Making metallic powder or suspensions thereof using chemical processes with reduction of metal compounds starting from liquid metal compounds, e.g. solutions
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00Nanotechnology for materials or surface science, e.g. nanocomposites

Abstract

本发明公开了一种防集聚广谱抗菌纳米银微粉及产业化制作工艺,包括在天然多孔隙植物材料的纤维元间与纤维上牢固地附着有超微粒银,其粒径为1~100纳米,该超微粒银的表层为2~8纳米的氧化银,核心为元素银。 The present invention discloses an anti-agglomeration broad antibacterial nano silver powder and industrial production process, including between the fibers in the porous element of natural plant material and firmly attached to the fibers silver ultrafine particle, a particle size of 1 to 100 nanometers the surface layer of silver ultrafine particles is from 2 to 8 nm silver oxide core of elemental silver. 本发明的方法能防止活性极强的银质超微粒子发生集聚,纳米银微粉具有极强的抗菌能力和广谱抗菌性,遇水杀菌力更强、无毒性、刺激性、过敏性和耐药性,并可作为原料药使用。 The method of the present invention can prevent the highly active silver ultrafine particle agglomeration occurs, nano-silver powder has a strong antimicrobial activity and a broad spectrum antibacterial, bactericidal water stronger, non-toxicity, irritation, and allergic drug resistance, and can be used as a drug.

Description

防集聚广谱抗菌纳米银微粉及产业化制作工艺 Anti-agglomeration powder spectrum antimicrobial nano silver and industrial production process

本发明是关于一种广谱抗菌纳米银材料及产业化制作工艺,更特别的,是关于一种防集聚广谱抗菌纳米银微粉及产业化制作工艺。 The present invention relates to a broad-spectrum antimicrobial nano silver materials and industrial production process, and more particularly, relates to an anti-agglomeration broad antibacterial nano silver powder and industrial production process.

从所周知,纳米技术是以1~100纳米粒径的物质作为研制和研究对象的新学科,它是21世纪经济发展的三大技术之一,它也是最有可能产生突破性成就的新技术。 From well known, nanotechnology is 1 to 100 nm particle size of the material as the development and study of new subjects, it is one of the three technologies of the 21st century economic development, it is also the most likely to produce ground-breaking achievements of new technology . 世界各国竞相投巨资,集精英奋力开发纳米技术及其应用,我国上至中央级下至高校、基层科研机构纷纷大力度投入纳米技术的开发热潮,尤其是纳米技术的应用和产业化将是我国研究开发的重中之重。 The world has invested heavily in competing, struggling to set elite development of nanotechnology and its applications, on the central level to the next country to universities, research institutions have a large grass-roots efforts put into the development boom in nanotechnology, in particular, nanotechnology and industrial applications will be the most important research and development in China.

在现有技术中公开了许多有关银抗菌的实例,如在日本专利昭54-151669中,公开了一种杀菌性布,其将含有铜、银(平均粒径6微米)的化合物单独或混合物的树脂溶液处理纱线,使该溶液均匀涂附在纱线的表面后再织成杀菌性布,该产品可作胶靴的衬里,帆布鞋和袜子。 Discloses numerous examples in the prior Antibacterial related art, as described in Japanese Patent No. Sho 54-151669 discloses a bactericidal cloth, which alone or in a mixture containing a copper, silver compound (average particle size 6 microns) resin was treated yarn, so that the solution was uniformly coated to the surface of the yarn and then woven into fabric bactericidal, the product can be used as a liner rubber boots, sneakers and socks.

在日本“加工技术”vol.17 NO.7报导中,用铜和硫化物处理腈纶纤维,得腈纶—硫化铜复合物,其对金葡球菌、大肠杆菌、枯草杆菌、皮肤丝状白癣菌有抑菌能力。 In Japan "Machine Technology" vol.17 NO.7 reported, treated with acrylic fiber and copper sulfide to give acrylic - copper sulfide complex, its Staphylococcus aureus, Escherichia coli, Bacillus subtilis, filamentous skin Trichophyton there are antibacterial activity.

在中国发明专利CN-87100231A,题目为“抗菌防臭纤维纱线及制造方法”,公开日:1987年11月18日中公开了一种抗菌纱线,其将腈纶纱线先后与铜、碱性绿-4复合交联,产品对金葡球菌、MRSA、白葡球菌、白色念珠菌等10个菌种有抑菌功能,其可用作抗菌防臭的内衣裤、袜、鞋垫和医药工业、食品工业的工作服。 In the Chinese patent CN-87100231A, entitled "Antibacterial and deodorant fiber yarn production method", Publication Date: 1987 November 18 discloses an antimicrobial yarn of Japan, which has copper acrylic yarn, basic green -4 composite crosslinked product has antibacterial function of Staphylococcus aureus, of MRSA, white staphylococcus aureus, Candida albicans and other 10 species, which are useful as antibacterial deodorant underwear, socks, insoles and pharmaceutical industries, food clothing industry.

在日本专利平3-136649,申请日“1989年10月24日中公开了一种预防奶牛乳房炎的抗菌布。其将银离子与聚丙烯腈以配位键形式复台,产品对链球菌、葡萄菌等6种菌种有抑制作用,可用作擦拭奶牛乳房乳头以预防奶牛的乳房炎的抗菌擦布。 Japanese Patent HEI 3-136649, filed "Japan on October 24, 1989 discloses a method of preventing mastitis in dairy cows antibacterial cloth. Which silver ion complex sets of polyacrylonitrile to form a coordinate bond, products of Streptococcus , six kinds of bacteria strains grape inhibition, can be used as wiping the udder teat to prevent the cow mastitis antibacterial cloth.

但上述文献或报道均未涉及用纳米银及适当载体作为抗菌材料。 However, none of the above documents or reporter relates nano silver and a suitable carrier as an antibacterial material.

以上这些产品均有抗菌作用,但是抗菌谱不广、作用不明显,并且与本发明完全不同。 These products have antibacterial activity, but not broad antibacterial spectrum, is not obvious, and is completely different from the present invention.

本发明的目的之一是提供一种广谱抗菌纳米银微粉及产业化制作工艺。 One object of the present invention is to provide a broad-spectrum antimicrobial nano silver powder and industrial production process.

本发明的目的之二是提供一种能防止活性极强的银质超微粒子之间发生集聚的工艺。 Second object of the present invention is to provide a highly active between the silver superfine particles can prevent the agglomeration process.

本发明的目的之三是提供一种防集聚广谱抗菌纳米银微粉的产业化制作工艺。 Another object of the present invention is to provide an anti-agglomeration three broad antibacterial nano silver micropowder industrial production process.

本发明的这些以及其它目的将通过下列详细说明和描述来进一步阐述。 These and other objects of the present invention will be further illustrated by the following detailed description and description.

在本发明中,本发明的防集聚广谱抗菌纳米银微粉,在天然多孔隙植物材料的纤维元间与纤维上牢固地附着有超微粒银,其粒径为1~100纳米,该超微粒银的表层为2~8纳米的氧化银,核心为元素银;在天然多孔隙植物材料的纤维元间与纤维上附着的纳米银的银含量为0.1~200毫克/克;所述的天然多孔隙植物材料为灯芯草、棉、毛、麻、丝、竹和木的纤维浆料,以及芦花、丝瓜络植物的茎、活性碳和化学纤维、无纺布织物、泡沫塑料等。 In the present invention, the anti-agglomeration broad spectrum antibacterial nanosilver powder according to the present invention, the natural porous element between the fibers and the fibrous plant material is firmly adhered silver ultrafine particles having a particle size of 1 to 100 nm, the ultrafine particles a surface layer of silver is 2 to 8 nm silver oxide core of elemental silver; silver content attached to the fibers between the fibers and natural porous element nanosilver plant material is 0.1 to 200 mg / g; the native polynucleotide pore rush plant material, cotton, wool, linen, silk, bamboo and wood fiber slurry, and aloe, loofah stems, activated carbon and chemical fibers, nonwoven fabric, foam and the like.

本发明的防集聚广谱抗菌纳米银微粉的产业化制作工艺,包括载体材料的真空前处理,药剂的配制、浸渍、增压均质、化学物理反应、清洗、干燥和粉碎步骤。 Anti-agglomeration spectrum antimicrobial nano silver fine powder of the present invention, the industrial production process, the support material comprises a vacuum pretreatment, formulation agent, dipping, pressure homogenization, chemical and physical reactions, washing, drying and pulverizing steps.

进一步的,在本发明的防集聚广谱抗菌纳米银微粉的产业化制作工艺中,所述的真空前处理包括用1~20%(V/V)的医用酒精(75~98%)将天然多孔隙植物材料(特别是灯芯草材料)浸没,然后真空提取得无有机成分的固体天然多孔隙植物材料。 Further, in the industrial production process of the present invention, the anti-agglomeration broad antibacterial spectrum of nano-silver powder, the vacuum pretreatment comprises 1 ~ 20% (V / V) of medical alcohol (75 to 98%) of native plant porous material (particularly rush material) was immersed and then vacuum without the extraction of the organic component porous solid natural plant materials.

在本发明的防集聚广谱抗菌纳米银微粉的产业化制作工艺中,所述的药剂配制配方为(按10公斤提取后载体计):A、硝酸银 0.01~1M,氨水 0.05~0.5M,氢氧化钠 0.01~0.3M加水至总体积为500升;B、葡萄糖或抗坏血酸 1~8M,硝酸 0.02~0.2M,乙醇 2~10M,加水至总体积为500升;将10体积份A加上1体积份B混合均匀后放置10~40分钟,将药剂浸渍载体,然后进行增压匀质,使之均匀,放入反应釜中并加入分散剂进行反应,至产品呈棕黄色。 In the industrial production process of the present invention, the anti-agglomeration broad spectrum antibacterial nano-silver powder in the formulation of pharmaceutical formulation (10 kg after extraction by carrier basis): A, silver nitrate, 0.01 ~ 1M, aqueous ammonia 0.05 ~ 0.5M, 0.01 ~ 0.3M sodium hydroxide was added water to a total volume of 500 liters; B, or ascorbic acid, glucose 1 ~ 8M, nitric acid 0.02 ~ 0.2M, ethanol, 2 ~ 10M, water was added to a total volume of 500 liters; 10 parts by volume of A plus B 1 part by volume mixed uniformly placed 10 to 40 minutes, the agent impregnated support, followed by pressurizing homogeneous and uniformly, into a reaction vessel and added dispersant reaction product to brown yellow.

在本发明的防集聚广谱抗菌纳米银微粉中,将所制备的纳米银微粉加入适当的医药辅助剂或赋型剂即可制得粉剂、片剂、膏剂、霜剂、膜剂、凝胶剂、贴剂、针剂、水剂、喷雾剂和生物医药芯片;所制备的银粉可用作野外、战地、灾区、航天领域中各种用途的杀菌材料,用于杀灭含菌水中的致病菌。 In the present invention the anti-agglomeration broad spectrum antibacterial nano-silver powder, a powder prepared nanosilver added suitable pharmaceutical auxiliaries or excipients to prepare powders, tablets, ointments, creams, films, gels , patches, injections, lotions, sprays and biomedical chip; silver materials prepared may be used as the sterilization field, field, disaster, various uses in the aerospace field, used to kill pathogenic bacteria in water bacteria.

在本发明中,如有必要,还可以加上一些本行业常规的处理方法,当然也可以按实际情况,包括结合本专业的常规知识省略一个或多个步骤,但只要能制备出产品即可。 In the present invention, if necessary, may also be treated with some conventional methods in the industry, of course, may be the actual situation, including in conjunction with general knowledge of a professional or more of the steps is omitted, as long as the product can be prepared .

本发明的产品可以作为治疗烧烫伤的医用(外)材料,和治疗外伤患者的皮肤感染和皮肤浅部真菌感染以及外科手术切口术后预防和治疗切口感染的材料,也可以作为日常生活用品,具有广谱抗菌性,长效性,杀灭耐药性致病菌,亲水性—遇水杀菌力更强、无毒性、无刺激性、无过敏性、无耐药性等优异性能。 Products of the invention may be used as well as skin infections and fungal infections after a surgical incision wound infection prevention and treatment of superficial skin material for medical treatment of burns (outer) material, and the treatment of trauma patients, can be used as daily necessities, having broad-spectrum antimicrobial, long-acting, to kill bacteria resistant, hydrophilic - water sterilization stronger, non-toxic, non-irritating, non-allergenic, non-resistance, excellent performance. 可用作治疗外伤患者的皮肤感染和皮肤真菌感染以及外科手术切口感染。 Useful in treating trauma patients fungal skin infections and skin infections and infected surgical incisions. 尤其是野外作业、战伤、海水污染创面的战伤、洪水、火灾、地震等不良环境条件下的现场防治外伤感染。 Especially in the field under the field work, war wounds, the wounds of war wounds marine pollution, floods, fires, earthquakes and other adverse environmental conditions, trauma, infection prevention and control. 更重要的是本发明的产品能用于治疗顽固性褥疮感染,烧烫伤创面感染,糖尿病后期下肢顽固性溃疡,妇女的细菌性、霉菌性及混合性感染阴道炎的防治,男性前列腺炎等疑难性感染,开创了纳米技术在人体抗感染领域应用的产业化范例。 More importantly, the products of the invention can be used in the treatment of refractory bedsore infections, burn wound infections, diabetes late intractable lower extremity ulcers, bacterial women, and mixed fungal vaginal infections prevention and treatment of male prostatitis and other difficult infections, creating industrial paradigm of nanotechnology applications in the field of human anti-infective.

本发明的技术在制作过程中,能防止新生成的表面活性很强的纳米级粒径的银质超微粒子之间发生集聚作用,从而防止生成粒径较大的银质粒子。 Technology in the production process of the present invention, the agglomeration can be prevented from acting between the silver superfine particles newly generated strong surfactant nano particle diameter, thereby preventing the generation of large particle size silver particles. 经实验室制作、中试,并投产成功,生产运行和产品质量稳定,年产值预计可达10亿元以上。 Production laboratory, pilot, and production is successful, stable production operation and product quality, the annual output value is expected to reach 10 billion yuan.

下面将通过附图及流程图来进一步的描述本发明。 The present invention is further described below by flowchart and accompanying drawings.

图1是未采用该技术的银质样品在显微镜的观测照片。 FIG 1 is a sample of the silver is not employed technique in microscope photograph observation.

图2是未采用该技术的银质样品在显微镜的观测照片。 FIG 2 is a sample of the silver is not used technique in microscope photograph observation.

图3是未采用该技术的银质样品在显微镜的观测照片。 FIG 3 is a sample of the silver is not used technique in microscope photograph observation.

图4是采用本发明技术的银质样品在显微镜的观测照片图5是本发明的工艺流程图。 Figure 4 is a sample of the present technology silver observed in a microscope photograph of FIG. 5 is a process flow diagram of the present invention.

本发明的防集聚广谱抗菌纳米银微粉(以下简称为PNSM)属于纳米材料学中在天然有机基质上分散了无机纳米微粒的有机—无机纳米复合材料。 Anti-agglomeration spectrum antimicrobial nano silver powder according to the present invention (hereinafter referred to as The PNSM) belonging nanomaterials Science inorganic nanoparticles dispersed in an organic matrix in natural organic - inorganic nanocomposites. 本发明PNSM的载体选用上从我们掌握的众多可以作为载体的物料中,取用灯芯草作为PNSM.的载体。 PNSM of the present invention on a carrier selected from a number of materials at our disposal can be used as a carrier, the access to rush as PNSM. Carrier. 有机载体为灯芯草,无机纳米则为粒径为1~100纳米的超微粒银,可以作为功能性材料具体应用在人体抗感染领域。 The organic carrier is a rush, compared with inorganic nano silver particle diameter of ultrafine particles of 1 to 100 nm, as the functional material can be used in particular human anti-infective art. 关于纳米材料的界定,除了粒径为1~100纳米外,还必须具备有此种纳米材料与宏观尺寸的同质材料相比,在某些重要性能上前者有远优于后者的特异性能。 About the definition of nanomaterials, in addition to a particle size of 1 to 100 nanometers, but also must have such nanomaterials have compared to macroscopic size of homogenous material, in some important properties of the former is far superior specificity of the latter can . 即要同时具有粒径1~100纳米和特异性能,两者缺一不可,否则就不能界定为纳米材料。 I.e., while having a particle size 1 to 100 nm and ~ specific energy, both are indispensable, otherwise it can not be defined as nanomaterials. 以粒径为1~100纳米的纳米超微粒子与同质的宏观微粒相比,前者的比表面极大,且与粒径大小成反比。 In diameter of 1 to 100 nanometers ultrafine particles compared with homogeneous macroscopic particles, the former great specific surface, and is inversely proportional to the particle size. 例如:1克铜当粒径为5纳米,其比表面为130米2/克;粒径为2纳米,其比表面为330米2/克;同时再加上表面效应即分布在粒子表面的体积百分数,当粒径为5纳米,其表面体积百分数为50%,粒径为2纳米时则为80%,此时由于粒径的减小,使处于表面层的原子数迅速增加,导致原配位不足,不饱和键外露增多,原子的表面能增高,致使这些纳米级的超微粒子的化学活性极强,因而当这些超微粒子刚刚生成的瞬间,不可避免的要发生相互碰撞,则此发生碰撞的两个,甚至多个超微粒就会发生集聚作用,由此导致生成粒径较大,能大于原粒径N,No,Noo倍的大粒子,甚至由于集聚作用而变成宏观尺寸的粒子,相应的其化学活性就大大降低,最终将失去纳米材料的性质。 For example: 1 g of copper when the particle diameter of 5 nm, a specific surface area of ​​130 m 2 / g; a particle diameter of 2 nm, a specific surface area of ​​330 m 2 / g; surface effect i.e. simultaneously coupled distributed on the surface of the particles volume percent, when the particle diameter of 5 nm, the surface volume percentage of 50%, particle diameter of 2 nm was 80%, this time due to the particle size decreases, the number of atoms in the surface layer is rapidly increased, leading to wife insufficient bits unsaturation exposed increased, the surface energy of atoms increases, so that the chemical activity of these nano-sized ultrafine particles is extremely strong, so just the moment when the ultrafine particles generated inevitable to collide with each other, then the collision two, even plurality of ultrafine particle agglomeration effect occurs, thereby causing to generate a larger particle size, the particle size can be larger than the original N, No, Noo times as large particles, even as particle agglomeration action becomes macroscopic size , whose respective chemical activity is greatly reduced, it will eventually lose properties of nanomaterials. 由此可见,本发明采用适当的化学和物理手段达到防止新生成的超微粒子间的集聚作用。 Thus, the present invention is the use of appropriate chemical and physical means to achieve the effect of preventing the agglomeration among ultrafine particles newly generated. 这种防集聚技术对于以化学法为主,物理法为辅的制作1~100纳米超微粒子的方法成功与否是至关重要的。 This anti-agglomeration technique for chemical based method, the production method, supplemented by physical methods ultrafine particles of 1 to 100 nm is critical success. 为了确证防集聚技术的效果,我们对采用和未采用该技术的银质样品进行电子显微镜检测并照相,其效果是明显的,请参看图1、图2、图3和图4。 To confirm the effect of the anti-agglomeration technique, we employed a sample of silver and is not employed in the art electron microscopy and photographed, the effect is significant, see Figure 1, 2, 3 and 4.

在图1~3中由于未采用本发明的防集聚技术的产品,图象中球状微粒的堆积物,其粒径远大于球状微粒的粒径。 In Figures 1 to 3 since no use of anti-agglomeration technique of the invention products, the image of the deposit spherical particles having a particle size much larger than the diameter of the spherical particles.

图4为采用防集聚技术的PNSM的电子显微图象,清晰地显示出PNSM上绝大部份的超微粒子的粒径为5~40纳米,且分布整齐、均匀,照片中部有一条状隆起,但是可以清楚的看出它不是球状超微粒子堆积,据分析可能是载体中纤毛表面的微小隆起。 FIG 4 is an electron microscope image PNSM the use of anti-agglomeration technique, clearly shows that the particle size of ultrafine particles PNSM vast majority of 5 to 40 nm, and the distribution of the neat, uniform, there is a photo-shaped central bulge , but you can clearly see that it is not spherical ultrafine particles accumulate, according to analysis may be tiny cilia uplift carrier surface. 此外为了测定PNSM上超微粒子的组成,经光电子能谱仪测定这些球形超微粒子其表层是2~8纳米厚的氧化银,其核心为元素银,用美国药典和英国药典所刊方法,测定PNSM上纳米银的银量为0.1~200毫克/克。 In addition to the measurement of the composition PNSM ultrafine particles, measured by photoelectron spectroscopy of these spherical ultrafine particles of silver oxide surface layer is from 2 to 8 nm thick, the core of elemental silver, and with the USP method laid down in British Pharmacopoeia, measuring PNSM the amount of silver of the nanosilver 0.1 to 200 mg / g.

本发明PNSM的功能及其检测试验如下: PNSM features of the present invention and its testing are as follows:

本发明的PNSM经电子显微镜和光电子能谱仪测定,可见其银质粒子绝大部份的粒径为5~40纳米的超微粒子,组成为Ag2O+Ag,粒子的表层为Ag2O,其核心为元素银故可以明确地界定为纳米级粒径的银质粒子,至于是否有优异的特殊性能,将通过下述的各项检测来证实,检测结果见表1和表2。 PNSM present invention by an electron microscope and measuring photoelectron spectrometer, which silver particles seen vast majority of ultrafine particles of a particle size of 5 to 40 nm, consisting of Ag, Ag2O + surface layer of Ag2O particles is, at its core therefore, elemental silver can be clearly defined as a nano particle diameter silver particles, as to whether there is excellent in specific properties, the following was confirmed by the testing, the test results in table 1 and table 2.

表1系由中国人民解放军全军医药试验中心微生物实验室检测。 Table 1 is detected by the Department of Experimental Medicine PLA PLA central microbiology laboratory.

表2系由上海医科大学华山医院细菌室检测。 Table 2 is detected by the Department of Shanghai Huashan Hospital, Medical University of bacteria.

本发明PNSM的抗菌机理为经典的抗菌机理: PNSM antibacterial mechanism of the present invention to classic antibacterial mechanism:

由上可见PNSM是通过最经典的抗菌机理,把菌体中赖以生存的酶中的-SH基团置换成-SAg使酶丧失活性导致病菌死亡,且其生成物是酶2SAg和H2O,不存在二次致病因素。 PNSM visible through the classic antibacterial mechanism, the survival of the cells in the enzyme -SH group replaced -SAg the enzyme activity leads to the loss of dead bacteria, and which product is an enzyme 2SAg and H2O, are not there is a secondary factor.

通过表1,表2所示的实验结果可以看出本发明的PNSM具有下列优越的特殊功能。 By Table 1, the experimental results shown in Table 2 can be seen PNSM the present invention has the following advantageous special features.

1、抗菌的广谱性:表1,表2所示的菌种,包括了格兰氏阳性菌,格兰氏阴性菌、真菌、芽胞和厌氧菌,如此广泛的抗菌谱,在现有的抗菌药物中是极为鲜见的。 1, broad spectrum antibacterial: Table 1, strains shown in Table 2, including Gram-positive bacteria, Gram-negative bacteria, fungi, and anaerobic spores, such a broad antibacterial spectrum, in the prior antimicrobial drugs is extremely uncommon. 就表1和表2所涉及的菌种除去重复的计有38个菌种,且大部份的菌种是从耐药强的临床患者分泌液中分离出来的。 Referring to Table 1 and Table 2 relates to strain removing repetitive strain gauge 38, and most of the strains isolated from patients with clinical resistance to strong secretions out.

2、长效性:表1,表2所示的洗涤50次和20次是PNSM每次用肥皂手工搓洗清水漂洗50次和20次。 2, long-term nature: Table 1, as shown in Table 2 and washed 50 times and 20 times are PNSM each hand soap scrub and rinse 50 times 20 times. 洗涤100次是每次用清水搓洗计100次,经过洗涤的PNSM.,其抑菌性能无明显减退。 Is washed 100 times 100 times per meter and scrubbing with water, washed through PNSM., No significant loss of its antimicrobial properties.

3、PNSM和8个抗菌药品对致病菌抑菌效果的比较:表1所示为本发明PNSM.(28)与红霉素(7),氨苄西林(4),头孢呋肟(4),头孢他啶(15),苯唑西林(2),庆大霉素(6),环丙沙星(14)8个抗菌药品同时进行体外抑菌试验。 3, PNSM antibacterial drugs and 8 compare the inhibitory effect on pathogens: shown in Table 1 of the present invention PNSM (28) and erythromycin (7), ampicillin (4), cefuroxime (4). , ceftazidime (15), oxacillin (2), gentamycin (6), ciprofloxacin (14) 8 antibacterial drugs antibacterial tests simultaneously. 在每个药品名称后面的括号中的数字为该药品能抑菌的菌种数。 The number following the name of each drug for the number of bacteria in parentheses can bacteriostatic drugs. 由此可见PNSM的抗耐药性致病菌能力比这8个抗菌药品要优越得多。 This shows the ability of anti-drug-resistant pathogens PNSM of vastly superior to the eight anti-bacterial drugs. 这对于打破当前的细菌的耐药性的增长,已使得抗生素的开发赶不上细菌耐药性增长的尴尬局面是可以寄予希望的。 This is to break the current growth of bacterial resistance, has made the development of bacterial resistance to antibiotics keep up with growth in the embarrassing situation of hope can be placed. 由上可以预见本发明的PNSM将可能逐步成为替代抗生素的替代药品。 On contemplated by the present invention will likely PNSM into alternative antibiotics alternative medicines.

4、亲水性—遇水杀菌力更强从表1,表2可见PNSM经多次搓洗,其抑菌力无明显减退,其主要机理就是PNSM上的Ag2O具缓释性能,一般在有水存在的条件下,甚至人体体表的湿度或敷用时的湿润状态的水量已足够使Ag+释出,当[Ag+]达到0.n-5ppm[10-6]时即可达到Ag+的动态平衡,而Ag+的最低抑菌浓度为2×10-11M,至于PNSM.的抗菌机理和在抗菌过程中不会产生二次致病因素在前面“抗菌机理”的部份已经阐明。 4, the hydrophilic - water scrub sterilization times stronger from Table 1, Table 2 PNSM through which no antibacterial power loss, which is the main mechanism of Ag2O with release properties on PNSM, typically water in the presence of, even when the water wet state body surface with sufficient moisture so that plating or Ag + release, when [Ag +] reaches 0.n-5ppm to achieve dynamic balance Ag + [10-6], the Ag + and the minimum inhibitory concentration of 2 × 10-11M, as for antibacterial mechanism the PNSM. and no secondary causative factors have been elucidated in the course of the antimicrobial part "antibacterial mechanism" in front. 另外还进行了下述试验,取0.5克PNSM的粗粉,每天用500毫升水浸泡,每天换水一次,45天后此PNSM粗粉的抑菌力无明显减退。 Also following test was conducted, 0.5 g PNSM take the meal, every day with 500 ml of water immersion, water once a day, 45 days after the force antibacterial coarse PNSM no significant decline. 所以用PNSM为原料药制成的外用药,遇水抗菌力更强。 Therefore, the use of external use prepared PNSM drug, stronger antibacterial water. 这对当前烧烫湿润疗法是很有利的。 It burns moist therapy is very beneficial to the current. 中国人民解放军南京总医院的临床验证其疗效很好,中国人民解放军第四军医大学及其附属西京医院,对海水污染的战伤的现场救治,证实本发明PNSM的疗效很好,实属当今世界领先水平,故特别适用于野外作业和战场等不良环境条件下作防治伤口的感染。 Nanjing People's Liberation Army General Hospital clinical validation of its good efficacy, Fourth Military Medical University Xijing Hospital affiliated and on-site treatment of war wounds to sea water pollution, confirming the good effect PNSM of the present invention, it is in today's world advanced level, it is especially suitable for field work and other adverse environmental condition to make a battlefield wound infection prevention and control.

5、药代动力学研究经国家北京新药安全评价研究中心和南京军区总医院药理科,用小鼠、豚鼠和大耳白家兔为试验对象。 5, pharmacokinetic studies by the National Beijing Center for New Drug Safety Evaluation and Research and the General Hospital of Nanjing Military Region, Pharmacology Department, mice, guinea pigs and rabbits were as test subjects. 用PNSM为实验药品经皮肤急性毒性试验,刺激性试验,过敏性试验和小鼠急性毒性实验,最大耐受量测定试验,和蓄积毒性试验,尤其是小鼠(9只)单次灌胃给予PNSM量为最大耐受量925毫克/公斤,相当于人拟用临床剂量的4625倍,给药后连续观察14天,未发现中毒症状及死亡,且生长情况较好。 Experimental drugs by the acute toxicity test skin irritation test, allergic and acute toxicity test in mice, the maximum tolerated dose was determined by PNSM test, accumulation and toxicity tests, in particular mice (nine) single intragastric administration PNSM maximum tolerated dose amount is 925 mg / kg, who intends to use the equivalent of 4625 times the clinical dose, continuously observed for 14 days after administration, symptoms of poisoning and death was not found, and the growth is better. 由此证实,PNSM无毒性,无刺激性,无过敏性,无耐药性。 It was thus confirmed, PNSM non-toxic, non-irritating, non-allergenic, non-resistance.

6、PNSM与同质宏观粒径的银微粒的体外抑菌之对比以园径均为6毫米的小圈,分别放置PNSM和粒径为微米级的银质微粉,前者的含银量仅为后者的10-3-10-1。 6, comparison of the in vitro antibacterial silver particles with a homogeneous macroscopic PNSM particle diameter to 6 mm are Parkway small circle, and were placed PNSM micronized particle size of micron-sized silver, the silver content of the former was only the latter of 10-3-10-1. 然而在体外抑菌的琼脂MH平板上,前者的抑菌环为12~20毫米,后者无抑菌环。 However, on agar plates MH vitro antibacterial, bacteriostatic former ring 12 is 20 mm, which is no inhibition zone. 由此可见在抑菌能力上,宏观尺寸的同质银微粒与PNSM是无法比拟的。 This shows in the antimicrobial activity, homogeneity silver particles with macroscopic size PNSM is unmatched.

综上所述,本发明的PNSM的功能包括抗菌的广谱性,长效性,对具有耐药性致病菌的抑菌能力,亲水性—遇水杀菌力更强,无毒性(包括无蓄积毒性),无刺激性,无过敏性、无耐药性等方面都具有远优于当前常用的抗菌药品,也远优于宏观尺寸的同质银微粉,因此本发明PNSM上的银质粒子既符合粒径为1~100纳米同时又显示有特殊优越的抗菌性能。 In summary, the present invention The PNSM features include a broad spectrum, long-acting antimicrobial and antibacterial activity of resistant pathogens, hydrophilic - water sterilization stronger, non-toxic (including no cumulative toxicity), non-irritating, non-allergenic, non-resistance to other aspects have far superior to currently used antibacterial drugs, far superior to homogenous macroscopic size of the silver fine powder, thus the present invention is the silver PNSM consistent with particle diameter of 1 to 100 nm while the special display excellent antibacterial properties. 所以本发明PNSM上的银质粒子可以毫无疑问地界定为纳米银。 Therefore, the silver particles of the present invention can undoubtedly PNSM define nanosilver.

PNSM的实质就是采用了本发明的防集聚技术而制造出在天然的质轻,多孔隙的灯芯草上均匀而牢固地附着了粒径1~100纳米的超微粒子的银质(Ag2O+Ag)粒子。 PNSM essence is the use of anti-agglomeration techniques of the present invention is produced in a natural lightweight, porous, the rush uniformly and firmly adhered to the particle size of 1 to 100 nm silver ultrafine particles (Ag2O + Ag) particle. 最后粉碎成微米级微粉,即得PNSM。 Finally pulverized into micron-sized powder, that was PNSM.

本发明的制作工艺为:选好载体原料在真空前处理中加入配剂1进行真空提取、浸渍,在进行浸渍的同时加入配剂2和配剂3增压均质,再进行化学物理反应,在化学物理反应中加入公散剂,然后进行清洗、干燥、粉碎、精粉即成品。 Production process of the present invention is: a carrier selected feedstock into a vacuum treatment prior to formulation 1 was subjected to vacuum extraction, impregnation, the impregnated simultaneously added during formulation 2 formulation 3 and the pressurized homogenizer, then physical chemical reaction, It was added in a chemical reaction known physical powders, then washed, dried, pulverized, i.e., the finished powder.

在本发明中,所有的原料及辅剂和添加剂均可以从市场购得,分散剂即本行业通用的防集聚剂,具体的品种可以从手册中查得,例如,可用的是异丙醇、十二烷基苯磺酸钠、琥珀酸酯磺酸钠、胶质钯或胶质钯、OP-10、三烷基磷酸酯类如磷酸三丁酯、磷酸三辛酯、磷酸三异戊酯、硫代磷酸三异辛酯等,也可参考1986年第2期硅酸盐通报第49~57页,沈君权“精细陶瓷用微粉的制备”一文。 In the present invention, all materials and adjuvants and additives are commercially available from the market, i.e. the dispersant of the present industry-wide anti-agglomeration agents, particularly from the species can Richard manuals, for example, usable are isopropanol, sodium dodecylbenzenesulfonate, sodium sulfosuccinate, colloidal palladium or palladium colloid, OP-10, trialkyl phosphites such as tributyl phosphate, trioctyl phosphate, tris isoamyl thiophosphate, tri-iso-octyl acrylate and the like, may refer to 1986 cERAMIC 2 pages 49 to 57, Scepter sink "fine ceramic powder prepared by the" article.

以下通过具体实施例来进一步说明本发明,但实施例仅用于说明并不能限制本发明范围。 The following invention is further illustrated by the specific embodiments, but the embodiments are illustrative only and do not limit the scope of the present invention.

在本发明若非特指所有的份、量均为以总重量为基础的重量单位,“M”为克分子浓度。 In the present invention, especially if not all parts, amounts are by weight based on the total weight of the unit based, "M" is the molarity.

例1按以下量配制药液(按10公斤载体计)A、AgNO30.5M, NH3·H2O 0.3M, NaOH 0.1M,加水至总体积为500升;B、葡萄糖 4M,HNO30.1M,煮沸1~5分钟,冷却后加入乙醇使成10M,体积为50升。 Example 1 A liquid preparation in the following amounts (by gauge carrier 10 kg) A, AgNO30.5M, NH3 · H2O 0.3M, NaOH 0.1M, with water to a total volume of 500 liters; B, glucose 4M, HNO30.1M, boil 1 to 5 minutes, cooled ethanol was added to make 10M, a volume of 50 liters.

将载体(灯芯草)洗净,加入98%浓度的医用酒精和蒸馏水(二者比例为1∶15),将载体浸没,真空提取至载体无有机成分和杂质,提取物供使用。 The carrier (rush) wash, add 98% of the concentration of medical alcohol and distilled water (1:15 ratio of the two), the support is immersed, vacuum extraction to the carrier and free of organic impurities content, extracts for use.

将10份+1份B(V/V)混匀后放置10~40分钟后即可供浸渍用,放入10公斤处理好的载体(灯芯草)。 After 10 parts + 1 part B (V / V) mixed is placed for 10 to 40 minutes after impregnation, the treated vector into 10 kg (rushes). 浸渍后增压均质使药液和载体混合均匀,进入反应釜进行化学和物理处理中还连续地加入分散剂-OP-10(在通风条件下和适当搅拌条件下),至灯芯草呈棕黄色,然后经清洗、干燥、粉碎即得本发明的防集聚广谱抗菌纳米银微粉。 After dipping and pressurized so that liquid carrier homogeneous mixing, into the reactor for chemical and physical treatments are also continuously added dispersant -OP-10 (under the appropriate ventilation and stirring conditions) to brownish rushes yellow, then cleaned, dried and pulverized to obtain anti-agglomeration broad spectrum antibacterial nano silver powder according to the present invention.

例2按以下量配制药液(按10公斤载体计)A、AgNO30.3M, NH3·H2O 0.2M, NaOH 0.07M,加水至总体积为500升;B、抗坏血酸 3M,HNO30.1M,煮沸1~5分钟,冷却后加入乙醇使成10M,体积为50升。 Example 2 A liquid preparation in the following amounts (by gauge carrier 10 kg) A, AgNO30.3M, NH3 · H2O 0.2M, NaOH 0.07M, adding water to a total volume of 500 liters; B, ascorbic 3M, HNO30.1M, boil 1 to 5 minutes, cooled ethanol was added to make 10M, a volume of 50 liters.

将载体(灯芯草)洗净,加入75%浓度的医用酒精和蒸馏水(二者比例为1∶10),将载体浸没,真空提取至载体无有机成分和杂质,提取物供使用。 The carrier (rush) wash, add 75% of the concentration of medical alcohol and distilled water (1:10 ratio of both), the support is immersed, vacuum extraction to the carrier and free of organic impurities content, extracts for use.

将10份+1份B(V/V)混匀后放置10~40分钟后即可供浸渍用,放入10公斤处理好的载体(灯芯草)。 After 10 parts + 1 part B (V / V) mixed is placed for 10 to 40 minutes after impregnation, the treated vector into 10 kg (rushes). 浸渍后增压均质使药液和载体混合均匀,进入反应釜进行化学和物理处理,加入十二烷基苯磺酸钠作为分散剂(在通风和适当搅拌条件下),至灯芯草呈棕黄色,然后经清洗、干燥、粉碎即得本发明的防集聚广谱抗菌纳米银微粉。 After dipping and pressurized so that liquid carrier homogeneous mixing, into the reactor for chemical and physical treatments, was added sodium dodecylbenzenesulfonate as a dispersant (in the proper aeration and agitation conditions) to brownish rushes yellow, then cleaned, dried and pulverized to obtain anti-agglomeration broad spectrum antibacterial nano silver powder according to the present invention.

本发明的防集聚广谱抗菌纳米银微粉以开发医药产品为主,经临床验证后可以供外用抗菌药品向内服抗菌药品发展,部份地替代抗生素。 Anti-agglomeration spectrum antimicrobial nano silver powder of the present invention to develop pharmaceutical products, clinical validation can be used for the topical antimicrobial pharmaceutical oral antibacterial drugs to develop, replace antibiotics partially. 同时还能涉及计其它多个产业,如纺织业可作床上用品、鞋袜和服装;在日用化上行业可作抗菌型洗涤剂、抗菌型洗发水、牙膏类、化妆品类和治疗痤疮面膜;在造纸业行业可作印钞用纸、纸餐具、书籍、文件和纸张;在食品行业可作为水果、蔬菜的灭菌、防腐和保鲜剂;在建材业可作为防霉抗菌涂料等;在旅游业可作为水消毒剂、抗菌型毛巾和餐饮服务业消毒剂;在保健业可作为抗菌型妇女卫生巾、抗菌型婴儿尿不湿和空调器、空气清新器中的抗菌材料。 While other terms involving multiple industries, such as textiles can be used for bedding, clothing and footwear; daily use in the industry can be used as antibacterial detergent, antibacterial shampoo, toothpaste, cosmetics and acne treatment mask ; in the paper industry can be used for printing paper, paper tableware, books, documents and papers; in the food industry as fruits, vegetables, sterilization, antiseptic and preservative; in the building materials industry can be used as antibacterial and antifungal coatings; in tourism as a water disinfectant, antibacterial towel and catering services disinfectants; antibacterial materials in the health industry can be used as antibacterial sanitary napkins, baby diapers antibacterial and air conditioners, air freshener in.

表1PNSM与8种抗菌药物的抑菌结果PNSM与对照组抑菌直径(mm)抗菌药物MIC法药敏结果菌 名 来 源 未洗涤 洗涤 洗涤 阴性 红霉素 苯唑 氨苄 头孢 头孢 头孢 庆大 环内50次 100次 对照 西林 西林 唑啉 呋肟 他啶 霉素 沙星金黄色葡萄球菌 ATCC25923 18 15 15 7 24 S S S S S S S大肠埃希菌 ATCC25922 13 13 12 7 10 S S S S S S铜绿假单胞菌 ATCC27853 12 12 12 7 6 S S S产气荚膜梭菌 CMCC(B)64606 10金黄色葡萄球菌(MRSA)分泌物 17 15 15 7 6 R R R R R R R表皮葡萄球菌 (MRSE)分泌物 18 15 16 7 6 R R R R R R R化脓性链球菌 分泌物 9 8 8 7 6 S S S S S S S淋病奈瑟菌 分泌物 10 10 10 7 31 S Table 1PNSM with eight kinds of antibacterial antibiotics with the control group results PNSM inhibitory diameter (mm) Origin Bacteria were not washed susceptibility results MIC method antibiotics erythromycin washed with wash negative oxacillin ampicillin cephem cephalosporin cephem celebration macrocycle 50 amoxicillin amoxicillin 100 times control oxazoline cefuroxime Betahistine neomycin gatifloxacin Staphylococcus aureus ATCC25923 18 15 15 7 24 SSSSSSS coli ATCC25922 13 13 12 7 10 SSSSSS Pseudomonas aeruginosa ATCC27853 12 12 12 7 6 SSS Clostridium perfringens CMCC (B) 64606 10 Staphylococcus aureus (MRSA) secretion 17 15 15 7 6 RRRRRRR Staphylococcus epidermidis (MRSE) secretion 18 15 16 7 6 RRRRRRR secretions pyogenes 988 7 6 SSSSSSS Neisseria secretion 10 10 10 7 31 S S S S S S大肠埃希菌 分泌物 17 14 14 7 6 R R R R R R阴沟肠杆菌 分泌物 9 8 8 7 11 R R R R R R产气肠杆菌 分泌物 14 12 13 7 6 R R R R R R铜绿假单胞菌 分泌物 15 15 15 7 6 R R R R R R嗜麦芽窄食单胞菌 分泌物 14 13 14 7 6 R R R S R S鲍曼不动杆菌 分泌物 13 12 12 7 19 R R R S S S肺炎克雷伯菌 分泌物 15 14 14 7 6 R R R S R S粘质沙雷菌 分泌物 16 13 14 7 6 R R R R R S费劳地枸橼酸杆菌 分泌物 11 10 11 7 6 R R R R R R雷积普罗维登菌 分泌物 15 13 13 7 6 R SSSSS coli secretion 17 14 14 7 6 RRRRRR secretion from Enterobacter cloacae 9 8 8 7 11 RRRRRR secretion from Enterobacter aerogenes 14 12 13 7 6 RRRRRR secretions of Pseudomonas aeruginosa 15 15 15 7 6 RRRRRR addicted maltophilia Aeromonas secretion 14 13 14 7 6 RRRSRS Acinetobacter baumannii secretions 13 12 12 7 19 RRRSSS secretions Klebsiella pneumoniae 15 14 14 7 6 RRRSRS Serratia marcescens secretion 161314 7 6 RRRRRS labor costs to Citrobacter secretions 11 10 11 7 6 RRRRRR bacterium Providencia mine product secretion 15 13 13 7 6 R R R S R S亲水气单胞菌 分泌物 13 11 13 7 16 R R R S R S温和气单胞菌 分泌物 14 12 12 7 17 R I I S R S创伤弧菌 分泌物 17 15 15 7 6 R R R S I S奇异变形杆菌 分泌物 11 10 10 7 9 R R R S R R普通变形杆菌 分泌物 11 9 11 7 6 R R R S R R潘氏变形杆菌 分泌物 10 9 10 7 6 R R I S R S白色念珠菌 分泌物 21 20 20 7 6热带念珠菌 分泌物 18 17 18 7 6近平滑念珠菌 分泌物 20 19 20 7 6光滑球拟酵母菌 分泌物 27 26 26 7 6注:S:敏感 I:中介 R:耐药表2菌株 空白 AB织物 PNS RRSRS hydrophilic Aeromonas secretion 13 11 13 7 16 RRRSRS Aeromonas bacteria secretions 14 12 12 7 17 RIISRS vulnificus secretions 17 15 15 7 6 RRRSIS secretions mirabilis 11 10 10 7 9 RRRSRR Proteus secretions 11 9 11 7 6 RRRSRR Pan Proteus secretions 10 9 10 7 6 RRISRS albicans discharge 21202076 Candida tropicalis secretions 18171876 parapsilosis secretions 20 192076 smooth Torulopsis 27262676 yeast secretion Note: S: sensitive I: mediation R: table 2 strain resistant fabric blank PNS AB M织物 未洗 洗20次 高压 未洗 高压 洗20次 洗50次绿脓杆菌 - - - - 15 13 16 16金黄色葡萄球菌 - - - - 15 17 15 15大肠杆菌 - - - - 13 14 18 15MRSA - - - - 14 14 17 15蜡样杆菌 - - - 11 13 13 15 15创伤弧菌 - - - - 16 16 16 17白色念珠菌 - 21 - - 11 11 11 11B群溶血性链球菌 - - - - 11 11 12 11嗜麦芽假单胞菌 - - - - 12 12 15 14硝酸盐阴性杆菌 - - - - 14 14 13 15丙型副伤寒沙门氏菌 - 12 - - 12 1 M did not wash fabric washing 20 times high-pressure high-pressure washing is not washed 20 50 Pseudomonas aeruginosa - - - - 15 13 is 16 16 Staphylococcus aureus - - - - 15 15. 17 15 E. coli - - - - 13 14 18 15MRSA - - - - 14 14. 17 15 cereus - - -. 11 15 15 13 is 13 is Vibrio vulnificus - - - - Candida albicans. 17 16 16 16 - 21 - - 11 11 11 11B hemolytic streptococcus group - - - - 11111211 Pseudomonas maltophilia - - - - 15 14 12 is 12 is negative bacilli nitrate - - - - 14 14 15 13 is Salmonella paratyphi C - 12 is - -. 1 12 is 4 19 14亚利桑那菌 - - - - 14 14 15 14枸橼酸杆菌 - - - - 14 14 15 13肺炎杆菌 - - - - 13 13 17 13枯草杆菌 - - - - 12 12 12 12摩根氏菌 - - - 10 12 12 12 12粪产硷杆菌 - - - - 14 12 16 16斯氏普图菲登氏菌 - - - - 12 12 14 13阴沟肠杆菌 - - - - 13 13 13 13淋球菌 - - - - 11 11 11 11以上结果表明PNSM对20株细菌均有抑制作用,且对易产生抗药性的细菌,如金黄色葡萄球菌耐药株(MRSA),绿脓杆菌,嗜麦芽假单胞菌及硝酸盐阴性杆菌等均有抑制作用, 41914 Arizona bacteria - - - - 14 14 15 14 Citrobacter - - - - 14 14 15 13 Klebsiella pneumoniae - - - - 13 13 17 13 Bacillus subtilis - - - - 12 12 12 12 morganii - - --1,012,121,212 alkaline Bacillus foecalis - - - - 14 12 is 16 16 Student's Putufeideng flexneri - - - - 14 12 is 12 is 13 is Enterobacter cloacae - - - - 13 is 13 is 13 is 13 is Neisseria gonorrhoeae - - - - 11 11 11 11 the results above show PNSM bacteria were inhibited 20 and resistant bacteria, drug-resistant strains such as Staphylococcus aureus (MRSA), Pseudomonas aeruginosa and easy, and Pseudomonas maltophilia nitrate-negative bacteria was inhibited, 压及洗涤20次及50次后均与未经洗涤一样,对抑菌作用无明显影响,而AB织物经洗涤20次后,对以上细菌均不能抑制,由此可见,PNSM的抑菌范围比AB织物广泛且不会因为洗涤而影响抑菌效果。 Pressure and washed after 20 and 50 in both times without washing the same, no significant effect on the inhibition of, and AB fabrics after washing 20 times, of the above bacteria can not be suppressed, shows that the range of antibacterial, The PNSM ratio AB extensive washing fabrics and will not affect the inhibitory effect.

Claims (7)

  1. 1.一种防集聚广谱抗菌纳米银微粉,其特征在于在灯芯草的纤维元间与纤维上牢固地附着有超微粒银,其粒径为5~40纳米,该超微粒银的表层为2~8纳米的氧化银,核心为元素银,在灯芯草的纤维元间与纤维上附着的纳米银的银含量为0.1~200毫克/克。 An anti-agglomeration broad antibacterial nano-silver powder, characterized in that between the fibers and the element rushes firmly adhered to the fiber super fine silver particles having a particle size of 5 to 40 nanometers, the surface layer of the silver superfine particles 2 to 8 nm silver oxide core is elemental silver, silver content attached to the fibers between the fibers and the element of nanosilver rushes from 0.1 to 200 mg / g.
  2. 2.如权利要求1所述的防集聚广谱抗菌纳米银微粉的制作工艺,其特征在于包括载体材料的真空前处理,药剂的配制、浸渍、增压均质、化学物理反应、清洗、干燥和粉碎步骤。 2. The manufacturing process of claim 1 anti-agglomeration broad antibacterial nanosilver powder as claimed in claim, characterized in that the support comprises a material before vacuum treatment, the pharmaceutical formulation, dipping, pressure homogenization, chemical and physical reactions, washing, drying and comminuting step.
  3. 3.如权利要求2所述的防集聚广谱抗菌纳米银微粉的制作工艺,其特征在于所述的真空前处理包括用1~20%(V/V)的医用酒精将灯芯草浸没,然后真空提取得无有机成分的固体灯芯草材料。 3. The production process of claim 2 anti-agglomeration broad antibacterial nanosilver powder as claimed in claim wherein said vacuum pretreatment comprises 1 ~ 20% (V / V) to rush medical alcohol immersion, then no mention in vacuo to obtain a solid component rushes organic material.
  4. 4.如权利要求2所述的防集聚广谱抗菌纳米银微粉的制作工艺,其特征在于所述的药剂配制配方按10公斤提取后载体计为:A、硝酸银0.01~1M,氨水0.05~0.5M,氢氧化钠0.01~0.3M,加水至总体积为500升;B、葡萄糖或抗坏血酸1~8M,硝酸0.02~0.2M,乙醇2~10M,加水至总体积为500升;将10体积份A加上1体积份B混合均匀后放置10~40分钟。 4. The production process of claim 2 anti-agglomeration broad antibacterial nanosilver powder as claimed in claim wherein said pharmaceutical formulation is formulated according to the terms of 10 kg extraction vector: A, silver nitrate, 0.01 ~ 1M, aqueous ammonia 0.05 0.5M, sodium hydroxide, 0.01 ~ 0.3M, with water to a total volume of 500 liters; B, or ascorbic acid, glucose 1 ~ 8M, nitric acid 0.02 ~ 0.2M, ethanol, 2 ~ 10M, water was added to a total volume of 500 liters; volume 10 A parts B plus 1 part by volume mixed uniformly placed 10 to 40 minutes.
  5. 5.如权利要求2所述的防集聚广谱抗菌纳米银微粉的制作工艺,其特征在于将药剂浸渍载体,然后进行增压匀质,使之均匀,放入反应釜中进行反应,并加入分散剂,至产品呈棕黄色。 5. The production process of claim 2 anti-agglomeration broad antibacterial nanosilver powder as claimed in claim, wherein the agent impregnated support, followed by pressurizing homogeneous and uniformly, into a reaction vessel in the reaction, and addition of dispersants, yellow to brownish product.
  6. 6.如权利要求2所述的防集聚广谱抗菌纳米银微粉的制作工艺,其特征在于将所制备的纳米银微粉加入医药辅助剂或赋型剂即可制得粉剂、片剂、膏剂、霜剂、膜剂、凝胶剂、贴剂、针剂、水剂、喷雾剂和生物医药芯片。 6. The production process of claim 2 anti-agglomeration broad antibacterial nanosilver powder as claimed in claim, characterized in that the powder prepared nanosilver added pharmaceutical adjuvant or excipient can be prepared powders, tablets, ointments, creams, films, gels, patches, injections, lotions, sprays and biomedical chip.
  7. 7.如权利要求2所制备的防集聚广谱抗菌纳米银微粉的应用,其特征在于所制备的银粉可用作野外、战地、灾区、航天领域中各种用途的杀菌材料,用于杀灭含菌水中的致病菌。 7. The anti-agglomeration broad antibacterial nano silver powder prepared by the application of claim 2, wherein the silver material is prepared may be used as the sterilization field, field, disaster, various uses in the aerospace field, for killing bacterial pathogens in the water.
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