CN1147640C - Method for making antibacterial fabric containing nm-class silver - Google Patents

Abstract

The present invention discloses a nano silver antibacterial fabric, or adhered on the fiber fabric between the super fine silver particles, ultrafine particle layer surface of silver is silver oxide, silver metal core, having a particle size of 1 to 900 nm. The fabric may be used for daily life, can treat skin infections and skin trauma patients superficial fungal infections as well as the prevention of postoperative surgical incision and treatment of functional fabric wound infection.

Description

Preparation of nano silver antibacterial fabric

The present invention relates to a method for producing a functional An antibacterial fabrics and, more particularly, relates to a silver nano antibacterial fabric and its manufacturing method.

Functional textiles based eighties was first proposed by German scientists, and quickly get a response in developed countries in the world have invested heavily in research and development, so far in portable medical functional fabric on the human body has come on the market and clinical application; but no breakthrough in the medical non-functional transplanted human fabric, mainly due to the definition of the fabric must be defined based on the fabric as the carrier, good stability, super-efficient of human disease, long-lasting, low toxicity of the therapy and adjuvant therapy functions, etc., is not the kind of simple medicines dip sprinkled with the kind of concept, essentially a brand-new new "drug distribution."

In Japanese Patent No. Sho 54-151669 discloses a bactericidal cloth, which contains copper, silver compound (average particle size 6 microns) was treated yarn alone or a resin mixture, the solution was uniformly coated to the yarn after the surface of the woven wire cloth bactericidal, the product can be used as a liner rubber boots, sneakers and socks.

In Japan "Machine Technology" vol.17 NO7 reported, treated with acrylic fiber and copper sulfide, copper sulfide to give an acrylic compound which has a suppression of Staphylococcus aureus, Escherichia coli, Bacillus subtilis, filamentous skin Trichophyton bacteria ability.

In the Chinese patent CN87100231A, entitled "Antibacterial and deodorant fabric manufacturing method", Publication Date: 1987 November 18 discloses an antibacterial fabric Japan, which has acrylic fabric and Cu +, Basic Green 4 Compound crosslinked products are antibacterial function of Staphylococcus aureus, MRSA, white staphylococcus aureus, Candida albicans and other 10 species, which can be used as anti-bacterial deodorant overalls underwear, socks, insoles and pharmaceutical industry, food industry.

In Japanese Patent HEI 3-136649, filing date: 1989 October 24 Japan discloses a method of preventing mastitis in dairy cows antibacterial cloth. The silver ion which complexes with the polyacrylonitrile to form a coordinate bond, products of Streptococcus, six kinds of bacteria strains grape inhibition, can be used as wiping the udder teat to prevent mastitis in dairy cows antibacterial cloth.

These products have antibacterial activity, but not broad antibacterial spectrum, is not obvious, and is completely different from the present invention.

One object of the present invention is to provide a method of manufacturing the antibacterial fabric.

Second object of the present invention is to provide a nano-silver antimicrobial fabric.

Another object of the present invention is to provide a three nano silver antibacterial fabric manufacturing method.

These and other objects of the present invention will be further illustrated by the following detailed description and description.

Antibacterial nanosilver fabric in the present invention, the attachment between the fibers in the fibrous web or on the ultra-fine silver particles have a surface layer of ultra-fine silver particles are silver oxide, silver metallic core, silver ultrafine particle diameter of 1 to 900 nanometers ; the amount of ultrafine particles of silver in the fibers or on the fibrous web adhering between 2 to 200 g / cm 2.

The method of preparing long-acting broad spectrum antibacterial nanosilver functional fabric of the present invention, comprises a finishing agent prepared according to the recipe, and then finishing the fabric padded, which was then kept in a hot air drying with sufficient oxygen conditions, washing and finally drying.

In the present invention, the finishing liquor containing fabric :( meter to 200 kg) of 5 to 30 kg of silver nitrate, 15 to 40 liters of ammonia water was added to 1,000 liters.

Further, finishing solution also contains 1 to 20 kg glucose.

Further, the present invention includes a finish :( fabric count to 200 kg) of 5 to 30 kg of silver nitrate, 15 to 40 liters of ammonia, sodium hydroxide 0.8 to 3 kg, of 0.2 to 10 kg of glucose, 0.2 to 0.5 liters of nitric acid, a total of 1000 liters of water balance.

In the present invention, padding the fabric finishing agent, pickup of 60 to 90%, and then drying with a hot air blowing and ventilation conditions at the time of 1 to 10 minutes at a temperature of 90 ~ 200 ℃, multiple washed, padding, pickup of 100% to 150%, and finally drying; the hot air drying may be drying, may be a heating roller, far infrared radiation heating, or the like.

Product of the invention may be used as a medical treatment of burns (outer) material, and the treatment of skin infections and trauma patients of a surgical incision after the material for the prevention and treatment of infections of the skin incision superficial fungal infections as well, it can be used as daily necessities.

Antibacterial mechanism of the present invention, the product is: Ag + easy to combine with the negative charge of the bacterial proteins mercapto group -SH, that the activity of the enzyme on which some bacteria survive the loss of activity, so as to achieve the inhibitory effect.

In the present invention, according to the classical theory, silver has good bactericidal action, bactericidal mechanism is: Silver is relatively stable material, substantially insoluble in water, and is itself bactericidal and antimicrobial spectrum neither so strong nor so extensive, that in the macro world is not resolved, we must seek answers to the microscopic world of nanoscience in , applied to the clinical treatment and prevention of disease. Silver Nano technology is based on the product of quantum chemistry, materials chemistry, biochemistry three basic subjects, the fine structure on the scale of the silver material to reach 10-9m order of nanometers, full advantage of its surface effects small size effect and use a variety of new and specific nature of the effect it reflects different from the macroscopic world of silver to achieve its long-acting, broad-spectrum, antibacterial, good stability, not only did not weaken the effectiveness of water, but enhanced features and in the process kill pathogens in the human body is not affected by pH and so on characteristics. At the same time strengthen the penetration of silver, promote myogenic convergence, exert its therapeutic function. Due to significantly increase its surface area, the surface structure is also changed greatly, greatly enhanced surface activity, and exhibit a very high specific functions tested, the MIC of the bacteria is 0.16 to 8.97 mg / ml, MBC TV ~ 3.05 81.97 mg / ml, the bactericidal capacity increased by 200 times.

Application of nano-silver technology to produce nanosilver fabric having broad application prospect in medical fabrics functional human non-engrafting in addition can be made into various antibacterial dressing applied to the human body surface, mucosal diseases, the prevention of diseases but can also ; in addition, more extensive on various antibacterial product development and application of human life, work, such as the production into a variety of anti-bacterial clothing, bedding, socks, shoes and so on textiles, light industrial products and hospital equipment. We can say that the application of nano-silver, human life will have a qualitative improvement, medical functional nano-silver fabric will set off a new round of industrial revolution, will promote the rapid growth and development of medical performance fabrics industry.

Antibacterial nanosilver fabric of the present invention (hereinafter referred to LBDF) After testing, the indicators are as follows: 1, long-term resistance: After the following three methods and then treated with the original product LBDF without any treatment for the in vitro antibacterial test together, the results confirmed LBDF and LBDF treated raw product that is essentially the same inhibitory effect.

(1) was washed 50 times with hand soap scrub, rinse, total 50 times; (2) washed 100 times with only a total of 100 times scrub cleaning; (3) LBDF immersed in water for 45 days (day changing the water).

2, broad-spectrum: (1) LBDF Antibacterial Test: conducted on LBDF MH plate (or Columbia agar or blood agar) Antibacterial test strain identification and susceptibility test Vitek-32 with bioMerieux, France microbial automatic analyzer. Test samples without any processing including raw materials and by the LBDF (1), LBDF (2) process. Antibacterial test species include gram-positive bacteria, Gram-negative bacteria, fungi spores and bacteria and a total of more than 40 species. LBDF these results demonstrate that more than 40 strains showed significant antibacterial function, and the plurality of species in addition to a few 40 is an international standard strain, was isolated from the majority of patients secretion strain which inhibition more bacteria difficult.

Antibacterial above test system by the People's Liberation Army Test Center Microbiology Laboratory Medicine, Huashan Hospital, Shanghai Medical University, bacteria and other famous room unit testing.

Antibacterial Results LBDF antibacterial fabric with the eight kinds of antibiotics and antibacterial fabric LBDF group antibacterial diameter antimicrobial susceptibility results MIC method bacteria were washed with a source of negative oxacillin, ampicillin-cephem cephalosporin cephalosporins erythromycin, gentamicin cyclopropylmethyl unwashed 50 amoxicillin amoxicillin 100 times control oxazoline cefuroxime Betahistine neomycin gatifloxacin Staphylococcus aureus ATCC25923 20 18 18 7 24 SSSSSSS coli ATCC25922 15 14 14 7 10 SSSSSS Pseudomonas aeruginosa ATCC27853 13 12 12 7 6 SSS Clostridium perfringens CMCC (B) 64606 10 Staphylococcus aureus (MRSE) secretion 19 17 17 7 6 RRRRRRR Staphylococcus epidermidis (MRSE) secretion 20 17 17 7 6 RRRRRRR secretions Streptococcus pyogenes 118 8 7 6 SSSSSSS Neisseria secretion 11 10 10 7 31 SSSSSS coli secretion 17 15 15 7 6 RRRRRR secretion from Enterobacter cloacae 10 8 8 7 11 RRRRRR aerogenes secretions 15131376 RRRRRR secretions of Pseudomonas aeruginosa 17 15 15 7 6 RRRRRR maltophilia Aeromonas secretion 16 13 14 7 6 RRRSRS Acinetobacter baumannii secretions 15 12 12 7 19 RRRSSS secretions 17 Klebsiella pneumoniae 14 14 7 6 RRRSRS Serratia marcescens secretions 18131476 R R R R R S costs of labor to Citrobacter secretions 13 10 10 7 6 R R R R R R Ray product Providencia bacterial secretion 15 13 13 7 6 R R R S R S hydrophilic Aeromonas secretion 13 11 13 7 16 R R R S R S

Aeromonas moderate secretion 14 12 12 7 17 RIISRS vulnificus secretions 19 17 17 7 6 RRRSIS secretions mirabilis 13 11 11 7 9 RRRSRR Proteus secretions 12 10 11 7 6 RRRSRR Paneth Proteus secretion 11 10 10 7 6 RRISRS albicans discharge 23212176 Candida tropicalis secretions 20171776 parapsilosis secretions 21202076 smooth Torulopsis yeast secretion 2,827,277 6 Note: S: sensitive I: mediation R: blank AB MS fabric wash fabric fabric 20 is not resistant strains unwashed high-pressure high-pressure washing washing 20 50 Pseudomonas aeruginosa - - - - 14. 17. 17 18 is Staphylococcus aureus - - - --17,171,717 coli - - - - 15 14 20 17MRSA - - - - 16 14 18 17 cereus - -. 11 - 15 Vibrio vulnificus. 17 15 15 - - - - 16 18 is 18 is Candida albicans. 19 --21 - - 13 11 11 13B hemolytic streptococcus group - - - - 13 is 13 is Pseudomonas maltophilia. 11 14 - - - - 14 16 nitrate 12 is negative bacilli. 17 - - - - 16 15 15. 17 Salmonella paratyphi C - 12 - - 14 16 21 16 Arizona bacteria - - - - 16 16 17 16 Citrobacter - - - - 16 16 17 15 Klebsiella pneumoniae - - - - 15 15 19 15 Bacillus subtilis - - - - 14 14 1414 morganii - - 10 - 14 14 14 14 manure produced alkaline bacillus - - - - 16 14 18 18 Steinmann Putufeideng coli - - - - 14 14 16 15 Enterobacter cloacae - - - - 15 15 1515 Neisseria gonorrhoeae - - - - 13 13 13 13

These results show that, the MS 20 are inhibited bacteria and resistant bacteria, drug-resistant strains such as Staphylococcus aureus (MRSA), Pseudomonas aeruginosa commutation, Pseudomonas maltophilia and nitrate negative bacillus was inhibited, and high-pressure washing and after 20 times and 50 times were not washed as no significant effect on the inhibition of, and has been enhanced, while AB fabrics after washing 20 times, of the above bacteria can not inhibition, we can see, the MS antibacterial fabrics and a wide range of bis AB fabric washing will not affect the inhibitory effect.

3, LBDF having excellent antibacterial activity to pathogenic bacteria for resistance to antibiotics LBDF 8 and 28 at the same time as the pathogen in vitro antibacterial test showed LBDF all 28 strains displayed a significant inhibition bacteria function, erythromycin only 8 strains have antibacterial function, oxacillin (2), ampicillin (4), cefazolin (4), cefuroxime (4), ceftazidime ( 15), gentamycin (6), ciprofloxacin (14).

Comparative tests proved LBDF vitro antibacterial antibiotics eight, indicating that bacteria on antibacterial function LBDF resistance has obvious advantages.

4, pharmacokinetic studies in guinea pigs and rabbits as test objects, LBDF acute toxicity test skin stimulation test, allergy test. Test: Nanjing Military Region General Hospital Pharmacology Department. The test results prove LBDF non-toxic, non-irritant, non-allergenic.

5, clinical validation After these tests have been carried out clinically proven, is now: plastic surgery for burns clinical reports of 50 cases (1) People's Liberation Army General Hospital of Nanjing burns.

(2) Jiangsu Provincial People's Hospital of general surgery for postoperative clinical reports of class II cuts.

(3) shallow skin Institute of Dermatology, Chinese Academy of Medical Sciences for clinical reports fungi.

There are also several hospitals Clinical trials are ongoing graft area, postoperative incisions tumors, burns, skin ulcers observation.

The following invention is further illustrated by the specific embodiments, but the embodiments are illustrative only, and not intended to limit the scope of the invention.

In the present invention, especially if not, all parts, amounts are based on the total weight of the weight of the unit.

Example 1 8 kg of silver nitrate was weighed, dissolved in 350 liters of water, 25 liters of concentrated aqueous ammonia was added, water was added so that a volume of 1,000 liters, and mixed well. Padding the fabric finishing liquor, a dip roll, rolling was 60%, and then drying under a hot air blowing and ventilation conditions, the time is 3 minutes, a temperature of 150 deg.] C, and then dip four four roll, mangle 100%, and finally dried, to obtain the present invention product.

Example 2 20 kg of silver nitrate was weighed, dissolved in 650 liters of water, 35 liters of concentrated aqueous ammonia was added, water was added so that a volume of 1,000 liters, and mixed well. Padding the fabric finishing liquor, a dip roll, rolling was 90%, and then drying with a far infrared heating and ventilation in the blast conditions, for 10 minutes at 180 ℃, and four dip four rolls, pickup of 120%, and finally dried, to obtain the present invention product.

Example 3 15 kg of silver nitrate was weighed, dissolved in 550 liters of water, 25 liters of concentrated aqueous ammonia was added, taking 3 kg glucose dissolved in 100 liters of water, water was added so that a volume of 1,000 liters, and mixed well. Padding the fabric finishing liquor, a dip roll, rolling was 60%, and then the exhaust blower with a heating roll drying conditions, time of 8 minutes at 110 deg.] C, and four dip four rolls, mangle 100%, and finally dried, to obtain the present invention product.

Example 4 28 kg of silver nitrate was weighed, dissolved in 750 liters of water, 35 liters of concentrated aqueous ammonia was added, taking 5 kg glucose dissolved in 100 liters of water, together with 0.3 liters of concentrated nitric acid, sodium hydroxide, 1 kg, a volume of water that makes the 1000 liters, and mixed well. Padding the fabric finishing liquor, a dip roll, rolling was 60%, and then under blast conditions with radiant heating and ventilation drying, for 10 minutes at 100 deg.] C, and four dip four rolling, rolling It was 100%, and finally dried, to obtain the present invention product.

Example 5 10 kg of silver nitrate was weighed, dissolved in 350 liters of water, concentrated aqueous ammonia was added 15 liters, 0.8 kg glucose taken, dissolved in 60 liters of water, together with 0.4 liters of concentrated nitric acid, 2 kg of sodium hydroxide, water was added so that a volume of 1000 liters, and mixed well. Padding the fabric finishing liquor, a dip roll, pickup of 90%, then under blast conditions with a radiant heating ventilation and drying time was 5 minutes at a temperature of 150 deg.] C, and four dip four rolling, rolling It was 100%, and finally dried, to obtain the present invention product.

Claims (3)

1. A method for preparing nanometer silver antibacterial fabric, wherein the fabric finishing liquor padding, and then holding under conditions sufficient oxygen drying with hot air, blowing time and under conditions for 1 to 10 minutes ventilation, temperature is 90 ~ 200 ℃, washed several times, padding, pickup of 100% to 150%, and finally drying said liquid formulation is a finishing :( fabric count to 200 kg) of 5 to 30 kg of silver nitrate, ammonia 15 to 40 liters, 1 to 20 kg glucose, water was added to 1,000 liters.

A method of preparing nanometer silver antibacterial fabric, wherein the fabric finishing liquor padding, and then holding under conditions sufficient oxygen drying with hot air, blowing time and under conditions for 1 to 10 minutes ventilation, temperature is 90 ~ 200 ℃, washed several times, padding, pickup of 100% to 150%, and finally drying said liquid formulation is a finishing :( fabric count to 200 kg) of 5 to 30 kg of silver nitrate, ammonia 15 to 40 liters, 0.8 to 3 kg of sodium hydroxide, 0.2 to 10 kg of glucose, 0.2 to 0.5 liters of nitric acid, water balance Total 1000 liters.

Preparation method of claim 12 nanometer silver antibacterial fabric as claimed in claim 3, characterized in that said hot-air drying may be drying, may be a heating roller, far infrared radiation heating, or the like.