CN117956967A - 含有高比重钠钙玻璃珠的化妆品制剂 - Google Patents
含有高比重钠钙玻璃珠的化妆品制剂 Download PDFInfo
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- CN117956967A CN117956967A CN202280061520.6A CN202280061520A CN117956967A CN 117956967 A CN117956967 A CN 117956967A CN 202280061520 A CN202280061520 A CN 202280061520A CN 117956967 A CN117956967 A CN 117956967A
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- Prior art keywords
- ethylhexyl
- inci
- glass beads
- cosmetic formulation
- formulation according
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- 239000011324 bead Substances 0.000 title claims abstract description 33
- 239000002537 cosmetic Substances 0.000 title claims abstract description 31
- 239000005361 soda-lime glass Substances 0.000 title claims abstract description 7
- 230000005484 gravity Effects 0.000 title claims abstract description 6
- 238000002360 preparation method Methods 0.000 title claims description 8
- 239000000203 mixture Substances 0.000 claims abstract description 50
- 238000009472 formulation Methods 0.000 claims abstract description 49
- -1 polydimethylsiloxane Polymers 0.000 claims description 37
- OSCJHTSDLYVCQC-UHFFFAOYSA-N 2-ethylhexyl 4-[[4-[4-(tert-butylcarbamoyl)anilino]-6-[4-(2-ethylhexoxycarbonyl)anilino]-1,3,5-triazin-2-yl]amino]benzoate Chemical compound C1=CC(C(=O)OCC(CC)CCCC)=CC=C1NC1=NC(NC=2C=CC(=CC=2)C(=O)NC(C)(C)C)=NC(NC=2C=CC(=CC=2)C(=O)OCC(CC)CCCC)=N1 OSCJHTSDLYVCQC-UHFFFAOYSA-N 0.000 claims description 32
- 239000011521 glass Substances 0.000 claims description 26
- 239000002245 particle Substances 0.000 claims description 18
- 150000001875 compounds Chemical class 0.000 claims description 13
- 239000003921 oil Substances 0.000 claims description 13
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 10
- 229940071160 cocoate Drugs 0.000 claims description 7
- OSORMYZMWHVFOZ-UHFFFAOYSA-N phenethyl benzoate Chemical compound C=1C=CC=CC=1C(=O)OCCC1=CC=CC=C1 OSORMYZMWHVFOZ-UHFFFAOYSA-N 0.000 claims description 7
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims description 6
- LFESLSYSZQYEIZ-UHFFFAOYSA-N 3-octanoyloxybutyl octanoate Chemical compound CCCCCCCC(=O)OCCC(C)OC(=O)CCCCCCC LFESLSYSZQYEIZ-UHFFFAOYSA-N 0.000 claims description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 6
- 229940114374 butylene glycol dicaprylate Drugs 0.000 claims description 6
- DLAHAXOYRFRPFQ-UHFFFAOYSA-N dodecyl benzoate Chemical compound CCCCCCCCCCCCOC(=O)C1=CC=CC=C1 DLAHAXOYRFRPFQ-UHFFFAOYSA-N 0.000 claims description 6
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 6
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims description 6
- FMJSMJQBSVNSBF-UHFFFAOYSA-N octocrylene Chemical compound C=1C=CC=CC=1C(=C(C#N)C(=O)OCC(CC)CCCC)C1=CC=CC=C1 FMJSMJQBSVNSBF-UHFFFAOYSA-N 0.000 claims description 6
- DXGLGDHPHMLXJC-UHFFFAOYSA-N oxybenzone Chemical compound OC1=CC(OC)=CC=C1C(=O)C1=CC=CC=C1 DXGLGDHPHMLXJC-UHFFFAOYSA-N 0.000 claims description 6
- 239000004033 plastic Substances 0.000 claims description 6
- 229920003023 plastic Polymers 0.000 claims description 6
- 239000007787 solid Substances 0.000 claims description 6
- ANZUDYZHSVGBRF-UHFFFAOYSA-N 3-ethylnonane-1,2,3-triol Chemical compound CCCCCCC(O)(CC)C(O)CO ANZUDYZHSVGBRF-UHFFFAOYSA-N 0.000 claims description 5
- FMRHJJZUHUTGKE-UHFFFAOYSA-N Ethylhexyl salicylate Chemical compound CCCCC(CC)COC(=O)C1=CC=CC=C1O FMRHJJZUHUTGKE-UHFFFAOYSA-N 0.000 claims description 5
- 239000007983 Tris buffer Substances 0.000 claims description 5
- 239000000839 emulsion Substances 0.000 claims description 5
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims description 4
- HEOCBCNFKCOKBX-RELGSGGGSA-N (1s,2e,4r)-4,7,7-trimethyl-2-[(4-methylphenyl)methylidene]bicyclo[2.2.1]heptan-3-one Chemical compound C1=CC(C)=CC=C1\C=C/1C(=O)[C@]2(C)CC[C@H]\1C2(C)C HEOCBCNFKCOKBX-RELGSGGGSA-N 0.000 claims description 4
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 4
- YVLPJIGOMTXXLP-UHFFFAOYSA-N 15-cis-phytoene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC(C)=CC=CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C YVLPJIGOMTXXLP-UHFFFAOYSA-N 0.000 claims description 4
- MPDGHEJMBKOTSU-YKLVYJNSSA-N 18beta-glycyrrhetic acid Chemical compound C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 claims description 4
- PBFGMXZRJIUGKU-UHFFFAOYSA-N 3-decanoyloxybutyl decanoate Chemical compound CCCCCCCCCC(=O)OCCC(C)OC(=O)CCCCCCCCC PBFGMXZRJIUGKU-UHFFFAOYSA-N 0.000 claims description 4
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 claims description 4
- YBGZDTIWKVFICR-JLHYYAGUSA-N Octyl 4-methoxycinnamic acid Chemical compound CCCCC(CC)COC(=O)\C=C\C1=CC=C(OC)C=C1 YBGZDTIWKVFICR-JLHYYAGUSA-N 0.000 claims description 4
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 4
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims description 4
- UCMIRNVEIXFBKS-UHFFFAOYSA-N beta-alanine Chemical compound NCCC(O)=O UCMIRNVEIXFBKS-UHFFFAOYSA-N 0.000 claims description 4
- 229920001577 copolymer Polymers 0.000 claims description 4
- CVSVTCORWBXHQV-UHFFFAOYSA-N creatine Chemical compound NC(=[NH2+])N(C)CC([O-])=O CVSVTCORWBXHQV-UHFFFAOYSA-N 0.000 claims description 4
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 claims description 4
- RXKJFZQQPQGTFL-UHFFFAOYSA-N dihydroxyacetone Chemical compound OCC(=O)CO RXKJFZQQPQGTFL-UHFFFAOYSA-N 0.000 claims description 4
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims description 4
- AGBQKNBQESQNJD-UHFFFAOYSA-N lipoic acid Chemical compound OC(=O)CCCCC1CCSS1 AGBQKNBQESQNJD-UHFFFAOYSA-N 0.000 claims description 4
- 230000008018 melting Effects 0.000 claims description 4
- 238000002844 melting Methods 0.000 claims description 4
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 4
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 claims description 4
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 claims description 4
- LEACJMVNYZDSKR-UHFFFAOYSA-N 2-octyldodecan-1-ol Chemical compound CCCCCCCCCCC(CO)CCCCCCCC LEACJMVNYZDSKR-UHFFFAOYSA-N 0.000 claims description 3
- HBTAOSGHCXUEKI-UHFFFAOYSA-N 4-chloro-n,n-dimethyl-3-nitrobenzenesulfonamide Chemical compound CN(C)S(=O)(=O)C1=CC=C(Cl)C([N+]([O-])=O)=C1 HBTAOSGHCXUEKI-UHFFFAOYSA-N 0.000 claims description 3
- XTJFFFGAUHQWII-UHFFFAOYSA-N Dibutyl adipate Chemical compound CCCCOC(=O)CCCCC(=O)OCCCC XTJFFFGAUHQWII-UHFFFAOYSA-N 0.000 claims description 3
- 239000004904 UV filter Substances 0.000 claims description 3
- 150000001298 alcohols Chemical class 0.000 claims description 3
- 125000000217 alkyl group Chemical group 0.000 claims description 3
- BTFJIXJJCSYFAL-UHFFFAOYSA-N arachidyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCO BTFJIXJJCSYFAL-UHFFFAOYSA-N 0.000 claims description 3
- 229940031578 diisopropyl adipate Drugs 0.000 claims description 3
- 239000003995 emulsifying agent Substances 0.000 claims description 3
- UVCJGUGAGLDPAA-UHFFFAOYSA-N ensulizole Chemical compound N1C2=CC(S(=O)(=O)O)=CC=C2N=C1C1=CC=CC=C1 UVCJGUGAGLDPAA-UHFFFAOYSA-N 0.000 claims description 3
- 229940068171 ethyl hexyl salicylate Drugs 0.000 claims description 3
- 229940049290 hydrogenated coco-glycerides Drugs 0.000 claims description 3
- 229940078812 myristyl myristate Drugs 0.000 claims description 3
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 3
- DZKXJUASMGQEMA-UHFFFAOYSA-N tetradecyl tetradecanoate Chemical compound CCCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCC DZKXJUASMGQEMA-UHFFFAOYSA-N 0.000 claims description 3
- 150000003626 triacylglycerols Chemical class 0.000 claims description 3
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 claims description 3
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims description 2
- KAZSKMJFUPEHHW-UHFFFAOYSA-N (2E)-3-[5-(1,1-dimethyl-2-propenyl)-4-hydroxy-2-methoxyphenyl]-1-(4-hdyroxyphenyl)-2-propen-1-one Natural products COC1=CC(O)=C(C(C)(C)C=C)C=C1C=CC(=O)C1=CC=C(O)C=C1 KAZSKMJFUPEHHW-UHFFFAOYSA-N 0.000 claims description 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 2
- OIQXFRANQVWXJF-QBFSEMIESA-N (2z)-2-benzylidene-4,7,7-trimethylbicyclo[2.2.1]heptan-3-one Chemical compound CC1(C)C2CCC1(C)C(=O)\C2=C/C1=CC=CC=C1 OIQXFRANQVWXJF-QBFSEMIESA-N 0.000 claims description 2
- AFDXODALSZRGIH-QPJJXVBHSA-N (E)-3-(4-methoxyphenyl)prop-2-enoic acid Chemical compound COC1=CC=C(\C=C\C(O)=O)C=C1 AFDXODALSZRGIH-QPJJXVBHSA-N 0.000 claims description 2
- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 claims description 2
- NKJOXAZJBOMXID-UHFFFAOYSA-N 1,1'-Oxybisoctane Chemical compound CCCCCCCCOCCCCCCCC NKJOXAZJBOMXID-UHFFFAOYSA-N 0.000 claims description 2
- 229940015975 1,2-hexanediol Drugs 0.000 claims description 2
- 229940031723 1,2-octanediol Drugs 0.000 claims description 2
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims description 2
- YVLPJIGOMTXXLP-UUKUAVTLSA-N 15,15'-cis-Phytoene Natural products C(=C\C=C/C=C(\CC/C=C(\CC/C=C(\CC/C=C(\C)/C)/C)/C)/C)(\CC/C=C(\CC/C=C(\CC/C=C(\C)/C)/C)/C)/C YVLPJIGOMTXXLP-UUKUAVTLSA-N 0.000 claims description 2
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- JUEPCARPXDIGAN-UHFFFAOYSA-N 18-hydroxyoctadecyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCCCCCCCCCCCCCCCCCO JUEPCARPXDIGAN-UHFFFAOYSA-N 0.000 claims description 2
- MEZZCSHVIGVWFI-UHFFFAOYSA-N 2,2'-Dihydroxy-4-methoxybenzophenone Chemical compound OC1=CC(OC)=CC=C1C(=O)C1=CC=CC=C1O MEZZCSHVIGVWFI-UHFFFAOYSA-N 0.000 claims description 2
- PFPQMWRASYNLMZ-LGIMBNBCSA-N 2-(3,4-dihydroxyphenyl)-3-[(2s,3r,4r,5s,6r)-3,4-dihydroxy-5-[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-[[(2r,3r,4r,5r,6s)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxy-5,7-dihydroxychromen-4-one Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1OC[C@@H]1[C@@H](O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)[C@H](O)[C@@H](O)[C@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 PFPQMWRASYNLMZ-LGIMBNBCSA-N 0.000 claims description 2
- PIKLCICIOVIUJV-UHFFFAOYSA-N 2-[2-(2,3-dihydroxypropoxy)-2-oxoethyl]-2-hydroxybutanedioic acid;octadecanoic acid Chemical compound OCC(O)COC(=O)CC(O)(C(O)=O)CC(O)=O.CCCCCCCCCCCCCCCCCC(O)=O PIKLCICIOVIUJV-UHFFFAOYSA-N 0.000 claims description 2
- 125000004174 2-benzimidazolyl group Chemical group [H]N1C(*)=NC2=C([H])C([H])=C([H])C([H])=C12 0.000 claims description 2
- RRSYNAMOFATAOU-UHFFFAOYSA-N 2-cyano-3-(2-octan-3-ylphenyl)-3-phenylprop-2-enoic acid Chemical compound CCCCCC(CC)C1=CC=CC=C1C(=C(C#N)C(O)=O)C1=CC=CC=C1 RRSYNAMOFATAOU-UHFFFAOYSA-N 0.000 claims description 2
- JGUMTYWKIBJSTN-UHFFFAOYSA-N 2-ethylhexyl 4-[[4,6-bis[4-(2-ethylhexoxycarbonyl)anilino]-1,3,5-triazin-2-yl]amino]benzoate Chemical compound C1=CC(C(=O)OCC(CC)CCCC)=CC=C1NC1=NC(NC=2C=CC(=CC=2)C(=O)OCC(CC)CCCC)=NC(NC=2C=CC(=CC=2)C(=O)OCC(CC)CCCC)=N1 JGUMTYWKIBJSTN-UHFFFAOYSA-N 0.000 claims description 2
- NPSJHQMIVNJLNN-UHFFFAOYSA-N 2-ethylhexyl 4-nitrobenzoate Chemical compound CCCCC(CC)COC(=O)C1=CC=C([N+]([O-])=O)C=C1 NPSJHQMIVNJLNN-UHFFFAOYSA-N 0.000 claims description 2
- 239000004808 2-ethylhexylester Substances 0.000 claims description 2
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Landscapes
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- Cosmetics (AREA)
Abstract
一种化妆品制剂,其包含至少一个油相以及比重为至少2.48g/cm3的钠钙玻璃珠。
Description
技术领域
本发明涉及一种化妆品制剂,其包含至少一个油相以及比重为至少2.48g/cm3的钠钙玻璃珠。
背景技术
看起来美丽和有吸引力的愿望是人类与生俱来的。即使美的典范随着时间的推移而发生变化,追求完美无瑕的外貌一直是人们的目标。皮肤的状况和外观在美丽和迷人的外表中占有重要分量。
为了使皮肤能够充分发挥其生物学功能,它需要定期清洁和护理。在此,皮肤清洁用于去除污垢、汗液和死皮颗粒残留物,它们形成各种病原体和寄生虫的理想温床。皮肤清洁通常借助表面活性制剂(肥皂、表面活性剂,更少见的是酒精制剂),这些制剂为发泡凝胶或固体(皂条)的形式,涂抹在皮肤上后用水再次冲洗掉。
护肤品,通常是面霜、软膏或洗液,主要用于皮肤的增湿和滋润。它们通常添加有活性成分,所述活性成分使皮肤再生,例如应防止和减少其过早老化(例如出现细纹、皱纹)。
然而,包括防晒剂在内的大量市售护肤品并不能掩盖这些现有技术制剂存在一系列缺点的事实。
为了被消费者接受,化妆用护肤品必须具有一定的感官特性。尤其是触觉特性在皮肤护理中占有重要地位。在皮肤上涂抹和摊开时,制剂应尽可能不会拉丝,而应当易于在皮肤上擦涂/摊开。此外,擦涂到皮肤上后,制剂不应在皮肤上留下任何残留物,即应尽可能少地"白化"。
发明内容
因此,本发明的目的是开发一种化妆用护肤品,它与现有技术的制剂相比"拉丝感"和"白化"现象明显降低。
根据现有技术的一种可能的减少"拉丝感"的解决方案在于在制剂中加入所谓的粉末原料,该粉末原料由在室温下呈固态的塑料颗粒组成。这些在室温下呈固态的塑料颗粒包括聚乙烯、聚丙烯、聚甲基丙烯酸甲酯或尼龙。这也是本发明对这些物质的定义。这种现有技术的缺点是,在所谓的"微塑料"讨论中,即在化妆品中使用塑料颗粒及其在化妆品使用后在环境中的去向的讨论中,这些物质的使用越来越被认为是不可取的。至于这种讨论是否合理以及合理到什么程度,在本文中暂且不论。但事实是,消费者对不再含有这些成分的化妆品越来越感兴趣。
因此,本发明的目的是在不使用在室温下为固体的塑料颗粒即聚乙烯、聚丙烯、聚甲基丙烯酸甲酯或尼龙的情况下,改善化妆用护肤品的触觉特性。
令人惊奇的是,这些目的可以通过一种化妆品制剂来达到,该制剂至少含有一个油相以及玻璃珠,该玻璃珠由比重(密度)为至少2.48g/cm3的钠钙玻璃珠组成。
在此,根据本发明优选的是,制剂不含在室温下为固体的塑料颗粒。
该解决方案尤其令人吃惊,因为作为原料的玻璃珠呈现为白色粉末,本领域技术人员必然假定这种特性会导致制剂在施加到皮肤上时"白化",因为玻璃珠不溶解在制剂中。
诚然,在化妆品制剂中,现有技术中已知含有钠钙玻璃珠的化妆品制剂。例如,DE10 2017 201869.0公开了由钠钙硼硅组成的玻璃珠的制剂。然而,它们具有比本发明的玻璃珠明显更低的密度(0.1-1.0g/cm3)。由经过感官训练的测试人员进行的测试表明,与本发明的玻璃珠相比,这些制剂倾向于更强的拉丝,并且更明显白化。
根据本发明有利的是,根据本发明的玻璃珠具有3至110微米的颗粒直径。根据本发明优选的是,在此玻璃珠具有3至20微米或70至110微米的颗粒直径。
玻璃珠的根据本发明粒径(颗粒直径)在此可以按照通常的标准确定,例如通过筛分。在此,本领域技术人员当然知道,粒径(粒度)总是存在一定的粒度分布。因此,粒度数据意味着不使用大于110微米的颗粒直径的较大玻璃珠,并且制剂中含有作为杂质的少量较小颗粒(例如由"碎玻璃"造成)是不重要的。
根据本发明有利的是,玻璃珠具有超过700℃的熔点。在此,根据本发明优选的是,熔点为约730℃。相比之下,DE 10 2017 201869.0中公开的3M公司的硼硅玻璃珠(GlassBubbles K15)具有低得多的熔点/软化温度,为550至650℃。
此外,根据本发明有利的是,根据ASTM D281-95测量,玻璃珠具有小于每立方厘米玻璃珠0.2克油的吸油量。
此外,本发明的根据本发明有利的实施方案的特征在于,玻璃珠具有1.4至1.6的折射率。在此,1.50至1.52的折射率根据本发明是优选的,特别优选1.51的折射率。
例如,Kuhmichel公司的玻璃珠"GP Cosmetics"或Prizmalite公司的玻璃珠"P2011SL Glass Microspheres"可用作根据本发明有利的玻璃珠。
根据本发明有利的是,制剂含有0.1至5重量%的量的玻璃珠,基于制剂的总重量。在此,根据本发明优选的是1至2.5重量%的含量,基于制剂的总重量。
本发明的根据本发明有利的实施方案的特征在于,制剂的油相含有一种或多种油成分,所述油成分选自以下化合物组:己二酸二异丙酯、辛酸/癸酸甘油三酯(INCICaprylic/Capric Triglycerides)、棕榈酸异丙酯、聚二甲基硅氧烷、环聚二甲基硅氧烷、辛基十二醇、椰油酸乙基己酯、肉豆蔻酸肉豆蔻酯、氢化椰油甘油类酯(INCI HydrogenatedCoco-Glycerides)、碳酸二辛酯、C18-38烷基羟基硬脂酰硬脂酸酯(INCI C18-38AlkylHydroxystearoryl Stearate)、己二酸二正丁酯、丁二醇二辛酸酯/癸酸酯(INCI ButyleneGlycol Dicaprylate/Dicaprate)、C12-15烷基苯甲酸酯(INCI C12-15Alkyl Benzoate)、2-苯乙基苯甲酸酯(INCI Phenethyl Benzoate)、二C12-13醇酒石酸酯(INCIDi-C12-13Alkyl Tatrate)、丁二醇椰油酸酯(INCI:Butylene Glycol Cocoate)、二辛基醚、新戊酸异癸酯、三癸基偏苯三酸酯、硬脂酸异丙酯、C12.13烷醇乳酸酯、辛酸2-丙基庚酯、异月桂酰肌氨酸异丙酯。
在此,根据本发明优选的油成分为己二酸二异丙酯、辛酸/癸酸甘油三酯(INCICaprylic/Capric Triglycerides)、辛基十二醇、椰油酸乙基己酯、肉豆蔻酸肉豆蔻酯、氢化椰油甘油类酯(INCI Hydrogenated Coco-Glycerides)、己二酸二正丁酯、丁二醇二辛酸酯/二癸酸酯(INCI Butylene Glycol Dicaprylate/Dicaprate)、苯甲酸C12-15烷基酯(INCI C12-15Alkyl Benzoate)、苯甲酸2-苯基乙基酯(INCIPhenethyl Benzoate)。
根据本发明有利的是,这些根据本发明有利的油成分的总用量为1至20重量%,基于制剂的总重量,其中优选的用量范围为2至15重量%,基于制剂的总重量。
根据本发明有利的是,根据本发明的制剂含有选自以下化合物组的一种或多种UV过滤剂:亚苯基-1,4-双-(2-苯并咪唑基)-3,3'-5,5'-四磺酸盐;2-苯基苯并咪唑-5-磺酸盐;1,4-二(2-氧代-10-磺基-3-亚冰片基甲基)-苯及其盐;4-(2-氧代-3-亚冰片基甲基)苯磺酸盐;2-甲基-5-(2-氧代-3-亚冰片基甲基)磺酸盐;2-(2H-苯并三唑-2-基)-4-甲基-6-[2-甲基-3-[1,3,3,3-四甲基-1-[(三甲基硅烷基)氧基]二硅氧烷基]丙基]-苯酚;3-(4-甲基亚苄基)樟脑;3-亚苄基樟脑;水杨酸乙基己酯;对苯二甲酸二樟脑磺酸;4-(二甲基氨基)苯甲酸(2-乙基己基)酯;4-(二甲基氨基)苯甲酸戊酯;4-甲氧基亚苄基丙二酸二(2-乙基己基)酯;4-甲氧基肉桂酸(2-乙基己基)酯;4-甲氧基肉桂酸异戊酯;2-羟基-4-甲氧基二苯甲酮;2-羟基-4-甲氧基-4'-甲基二苯甲酮;2,2'-二羟基-4-甲氧基二苯甲酮;2-(4'-二乙氨基-2'-羟基苯甲酰基)苯甲酸己酯;4-(叔丁基)-4'-甲氧基二苯甲酰甲烷;水杨酸高孟酯;2-乙基己基-2-羟基苯甲酸酯;2-乙基己基-2-氰基-3,3-二苯基丙烯酸酯;二甲基二乙基亚苄基丙二酸酯;2-乙基己基-2-氰基-3,3-二苯基丙烯酸酯;3-(4-(2,2-双乙氧基羰基乙烯基)-苯氧基)丙烯基)-甲氧基硅氧烷/二甲基硅氧烷共聚物;二辛基丁胺基三唑酮(INCI:二乙基己基丁酰胺基三唑酮);2,4-双-[5-1(二甲基丙基)苯并噁唑-2-基-(4-苯基)-亚氨基]-6-(2-乙基己基)-亚氨基-1,3,5-三嗪(CAS编号288254-16-0);4,4',4”-(1,3,5-三嗪-2,4,6-三基三亚氨基)-三苯甲酸三(2-乙基己基酯)(又名:2,4,6-三[苯胺基-(对羧基-2'-乙基-1'-己氧基)]-1,3,5-三嗪(INCI:乙基己基三嗪酮);2,4-双-{[4-(2-乙基己氧基)-2-羟基]-苯基}-6-(4-甲氧基苯基)-1,3,5-三嗪;4-二氰基亚甲基-2,6-二甲基-1,4-二氢吡啶-N-(乙氧基硫酸酯盐)、二氧化钛;氧化锌。
在此,根据本发明优选的是,根据本发明的制剂不含3-(4-甲基亚苄基)-樟脑、2-羟基-4-甲氧基二苯甲酮(INCI:羟苯甲酮)、4-甲氧基肉桂酸2-乙基己酯(INCI:甲氧基肉桂酸辛酯)、乙基己基-2-氰基-3,3-二苯基丙烯酸酯(INCI:奥克立林)、对羟基苯甲酸酯(特别是对羟基苯甲酸甲基酯、对羟基苯甲酸丙基酯和对羟基苯甲酸丁基酯)、甲基异噻唑啉酮、氯甲基异噻唑啉酮和DMDM乙内酰脲、聚乙二醇醚或聚乙二醇酯。
相比之下,根据本发明特别优选的是使用4-(叔丁基)-4'-甲氧基二苯甲酰甲烷、2-(4'-二乙基氨基-2'-羟基苯甲酰基)-苯甲酸己基酯(INCI:二乙氨基羟基苯甲酰基己基苯甲酸酯)、2-苯基苯并咪唑-5-磺酸盐、水杨酸乙基己酯;二辛基丁胺基三唑酮(INCI:二乙基己基丁酰胺基三唑酮)、4,4',4”-(1,3,5-三嗪-2,4,6-三基三亚氨基)-三苯甲酸三(2-乙基己酯)(又称:2,4,6-三-[苯胺-(对羧基-2'-乙基-1'-己氧基)]-1,3,5-三嗪(INCI:乙基己基三唑酮)和2,4-双-{[4-(2-乙基己氧基)-2-羟基]-苯基}-6-(4-甲氧基苯基)-1,3,5-三嗪,其中这些UV过滤剂可以单独使用或者作为混合物使用。
本发明的根据本发明有利的实施方案的特征在于,制剂为乳剂形式。在此,根据本发明优选的是O/W乳剂(水包油型乳剂)。
在这种情况下,根据本发明特别有利的是,制剂以用一种或多种乳化剂进行乳化的O/W型乳剂的形式存在,所述乳化剂选自以下化合物组:硬脂酸柠檬酸甘油酯、硬脂酸甘油酯(自乳化)、硬脂酸、硬脂酸盐、聚甘油-3-甲基葡萄糖二硬脂酸酯、硬脂酰谷氨酸钠、鲸蜡硬脂醇硫酸酯钠、鲸蜡醇磷酸酯钾、鲸蜡硬脂基磺基琥珀酸酯、聚甘油-10硬脂酸酯、聚甘油-10月桂酸酯、聚甘油-10癸酸酯。这些乳化剂通常以0.5至10重量%(基于制剂的总重量)的总浓度使用。
就本发明而言有利的是,制剂含有一种或多种选自以下化合物组的醇类:乙醇、甘油、乙基己基甘油、苯氧乙醇、聚甘油-2癸酸酯、丙二醇、丁二醇、2-甲基丙烷-1,3-二醇、1,2-戊二醇、1,2-己二醇、1,2-辛二醇、1,2-癸二醇。这些醇可以以0.2至10重量%的总浓度使用,基于制剂的总重量。
本发明的根据本发明有利的实施方案的特征在于,制剂包含一种或多种选自以下化合物组的化合物:α-硫辛酸、叶酸、八氢番茄红素、D-生物素、辅酶Q10、α-葡糖基芦丁、肉碱、肌肽、异黄酮、类黄酮、肌酸、肌酐、牛磺酸、β-丙氨酸、泛醇、聚多卡醇、生育酚醋酸酯、二羟基丙酮、甘油葡萄糖、(2-羟乙基)脲、维生素E或维生素E乙酸酯、透明质酸和/或其钠盐、薄荷醇、甘草次酸和/或甘草查耳酮A。
根据本发明还有利的是,制剂含有乙醇和/或乙基己基甘油。根据本发明特别优选的是使用乙基己基甘油。
最后但并非不重要的是,根据本发明有利的是,制剂含有一种或多种选自以下化合物组的聚合物:黄原胶、木薯淀粉、羟乙基纤维素、乙烯基吡咯烷酮/十六碳烯共聚物。
此外,该化妆品制剂可以按照与此类情况下常用的化妆品那样组成,并含有相应的已知成分。
具体实施方式
比较试验
制备了以下配方,并使用33名经过专门培训的女性受试者组成的受试者小组,测定了涂抹在皮肤上之后的"拉丝"和"白化"。成分的用量以重量%表示。
配方
拉丝(凝聚性,粘连性)
拉丝是通过评估涂抹在手掌上的制剂在断裂前被拉开时在手指和手掌之间形成的丝的长度来确定的。评价标准从"不形成丝"到"形成很长的丝",并通过视觉感知。
共有33名经过训练的女性受试者接受了随机和平衡的产品展示顺序。
描述性统计结果以表格形式列出了差异程度的平均值。
通过配对t检验(双侧假设检验,显著性=0.1和0.05),归纳统计实现对产品的比较。
结果
*产品变化显著(p值≤5%),强度较高。
实施例
以下实施例旨在说明本发明,而不对其进行限制。除非另有说明,所有数量、比例和百分比均基于重量和总量或制剂的总重量。
Claims (16)
1.一种化妆品制剂,其包含至少一个油相以及比重为至少2.48g/cm3的钠钙玻璃珠。
2.根据权利要求1所述的化妆品制剂,其特征在于,所述制剂不含在室温下为固体的塑料颗粒。
3.根据前述权利要求中任一项所述的化妆品制剂,其特征在于,所述玻璃珠具有3至110微米的颗粒直径。
4.根据前述权利要求中任一项所述的化妆品制剂,其特征在于,所述玻璃珠具有超过700℃的熔点。
5.根据前述权利要求中任一项所述的化妆品制剂,其特征在于,根据ASTM D281-95测量,所述玻璃珠具有小于每立方厘米玻璃珠0.2克油的吸油量。
6.根据前述权利要求中任一项所述的化妆品制剂,其特征在于,所述玻璃珠具有1.4至1.6的折射率。
7.根据前述权利要求中任一项所述的化妆品制剂,其特征在于,所述制剂含有0.1至5重量%的量的玻璃珠,基于制剂的总重量。
8.根据前述权利要求中任一项所述的化妆品制剂,其特征在于,所述制剂的油相含有一种或多种油成分,所述油成分选自以下化合物组:己二酸二异丙酯、辛酸/癸酸甘油三酯(INCI Caprylic/Capric Triglycerides)、棕榈酸异丙酯、聚二甲基硅氧烷、环聚二甲基硅氧烷、辛基十二醇、椰油酸乙基己酯、肉豆蔻酸肉豆蔻酯、氢化椰油甘油类酯(INCIHydrogenated Coco-Glycerides)、碳酸二辛酯、C18-38醇羟基硬脂酰硬脂酸酯(INCI C18-38 Alkyl Hydroxystearoryl Stearate)、己二酸二正丁酯、丁二醇二辛酸酯/癸酸酯(INCIButylene Glycol Dicaprylate/Dicaprate)、C12-15烷基苯甲酸酯(INCI C12-15 AlkylBenzoate)、2-苯乙基苯甲酸酯(INCI Phenethyl Benzoate)、二C12-13醇酒石酸酯(INCIDi-C12-13 Alkyl Tatrate)、丁二醇椰油酸酯(INCI:Butylene Glycol Cocoate)、二辛基醚、新戊酸异癸酯、三癸基偏苯三酸酯、硬脂酸异丙酯、C12.13烷醇乳酸酯、辛酸2-丙基庚酯、异月桂酰肌氨酸异丙酯。
9.根据前述权利要求中任一项所述的化妆品制剂,其特征在于,所述制剂含有选自以下化合物组的一种或多种UV过滤剂:亚苯基-1,4-双-(2-苯并咪唑基)-3,3'-5,5'-四磺酸盐;2-苯基苯并咪唑-5-磺酸盐;1,4-二(2-氧代-10-磺基-3-亚冰片基甲基)-苯及其盐;4-(2-氧代-3-亚冰片基甲基)苯磺酸盐;2-甲基-5-(2-氧代-3-亚冰片基甲基)磺酸盐;2-(2H-苯并三唑-2-基)-4-甲基-6-[2-甲基-3-[1,3,3,3-四甲基-1-[(三甲基硅烷基)氧基]二硅氧烷基]丙基]-苯酚;3-(4-甲基亚苄基)樟脑;3-亚苄基樟脑;水杨酸乙基己酯;对苯二甲酸二樟脑磺酸;4-(二甲基氨基)苯甲酸(2-乙基己基)酯;4-(二甲基氨基)苯甲酸戊酯;4-甲氧基亚苄基丙二酸二(2-乙基己基)酯;4-甲氧基肉桂酸(2-乙基己基)酯;4-甲氧基肉桂酸异戊酯;2-羟基-4-甲氧基二苯甲酮;2-羟基-4-甲氧基-4'-甲基二苯甲酮;2,2'-二羟基-4-甲氧基二苯甲酮;2-(4'-二乙氨基-2'-羟基苯甲酰基)苯甲酸己酯;4-(叔丁基)-4'-甲氧基二苯甲酰甲烷;水杨酸高孟酯;2-乙基己基-2-羟基苯甲酸酯;2-乙基己基-2-氰基-3,3-二苯基丙烯酸酯;二甲基二乙基亚苄基丙二酸酯;2-乙基己基-2-氰基-3,3-二苯基丙烯酸酯;3-(4-(2,2-双乙氧基羰基乙烯基)-苯氧基)丙烯基)-甲氧基硅氧烷/二甲基硅氧烷共聚物;二辛基丁胺基三唑酮(INCI:二乙基己基丁酰胺基三唑酮);2,4-双-[5-1(二甲基丙基)苯并噁唑-2-基-(4-苯基)-亚氨基]-6-(2-乙基己基)-亚氨基-1,3,5-三嗪(CAS编号288254-16-0);4,4',4”-(1,3,5-三嗪-2,4,6-三基三亚氨基)-三苯甲酸三(2-乙基己基酯)(又名:2,4,6-三[苯胺基-(对羧基-2'-乙基-1'-己氧基)]-1,3,5-三嗪(INCI:乙基己基三嗪酮);2,4-双-{[4-(2-乙基己氧基)-2-羟基]-苯基}-6-(4-甲氧基苯基)-1,3,5-三嗪;4-二氰基亚甲基-2,6-二甲基-1,4-二氢吡啶-N-(乙氧基硫酸酯盐)、二氧化钛;氧化锌。
10.根据前述权利要求中任一项所述的化妆品制剂,其特征在于,所述制剂以乳剂形式存在。
11.根据前述权利要求中任一项所述的化妆品制剂,其特征在于,所述制剂以用一种或多种乳化剂进行乳化的O/W型乳剂的形式存在,所述乳化剂选自以下化合物组:硬脂酸柠檬酸甘油酯、硬脂酸甘油酯(自乳化)、硬脂酸、硬脂酸盐、聚甘油-3-甲基葡萄糖二硬脂酸酯、硬脂酰谷氨酸钠、鲸蜡硬脂醇硫酸酯钠、鲸蜡醇磷酸酯钾、鲸蜡硬脂基磺基琥珀酸酯、聚甘油-10硬脂酸酯、聚甘油-10月桂酸酯、聚甘油-10癸酸酯。
12.根据前述权利要求中任一项所述的化妆品制剂,其特征在于,所述制剂含有一种或多种选自以下化合物组的醇类:乙醇、甘油、乙基己基甘油、苯氧乙醇、聚甘油-2癸酸酯、丙二醇、丁二醇、2-甲基丙烷-1,3-二醇、1,2-戊二醇、1,2-己二醇、1,2-辛二醇、1,2-癸二醇。
13.根据前述权利要求中任一项所述的化妆品制剂,其特征在于,所述制剂包含一种或多种选自以下化合物组的化合物:α-硫辛酸、叶酸、八氢番茄红素、D-生物素、辅酶Q10、α-葡糖基芦丁、肉碱、肌肽、异黄酮、类黄酮、肌酸、肌酐、牛磺酸、β-丙氨酸、泛醇、聚多卡醇、生育酚醋酸酯、二羟基丙酮、甘油葡萄糖、(2-羟乙基)脲、维生素E或维生素E乙酸酯、透明质酸和/或其钠盐、薄荷醇、甘草次酸和/或甘草查耳酮A。
14.根据前述权利要求中任一项所述的化妆品制剂,其特征在于,所述制剂含有一种或多种选自以下化合物组的聚合物:黄原胶、木薯淀粉、羟乙基纤维素、乙烯基吡咯烷酮/十六碳烯共聚物。
15.根据前述权利要求中任一项所述的化妆品制剂,其特征在于,所述制剂不含3-(4-甲基亚苄基)-樟脑、2-羟基-4-甲氧基二苯甲酮(INCI:羟苯甲酮)、4-甲氧基肉桂酸2-乙基己酯(INCI:甲氧基肉桂酸辛酯)、乙基己基-2-氰基-3,3-二苯基丙烯酸酯(INCI:奥克立林)、对羟基苯甲酸酯(特别是对羟基苯甲酸甲基酯、对羟基苯甲酸丙基酯和对羟基苯甲酸丁基酯)、甲基异噻唑啉酮、氯甲基异噻唑啉酮和DMDM乙内酰脲、聚乙二醇醚或聚乙二醇酯。
16.根据前述权利要求中任一项所述的化妆品制剂,其特征在于,所述制剂含有乙醇和/或乙基己基甘油。
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