AU2016273839A1

AU2016273839A1 - Sunscreen containing titanium dioxide

Info

Publication number: AU2016273839A1
Application number: AU2016273839A
Authority: AU
Inventors: Anja Eitrich; Dominik Goddertz; Anja Pasternak; Katharina Reiter; Juliane Schade; Sarah Sprock
Original assignee: Beiersdorf AG
Current assignee: Beiersdorf AG
Priority date: 2015-11-25
Filing date: 2016-12-12
Publication date: 2017-06-08
Also published as: DE102015223261A1; BR102016026797B1; BR102016026797A2; CN107028777B; CN107028777A; EP3173130B1; ES2781977T3; EP3173130A1

Abstract

According to the present invention there is provided a cosmetic preparation generally comprised of a) 2-ethylhexyl-2-cyano-3,3-diphenyl acrylate (octocrylene), b) ethanol and c) titanium dioxide in the rutile crystal structure with a primary particle size of 2-100 nm. Preferably, the preparation according to the invention contains titanium dioxide in the rutile crystal structure. Alternatively, the titanium dioxide is present in the crystal structure if the total amount of other crystal structures does not exceed 1% by weight, based on the total amount of titanium dioxide.

Description

SUNSCREEN CONTAINING TITANIUM DIOXIDE Field of the Invention

The present invention relates to a cosmetic preparation containing 2-ethylhexyl-2-cyano-3,3-diphenyl acrylate (octocrylene), ethanol and titanium dioxide in the rutile crystal structure with a primary particle size of 2-100 nm.

Background of the Invention

Any discussion of the prior art throughout the specification should in no way be considered as an admission that such prior art is widely known or forms part of common general knowledge in the field.

The trend away from the pale skin of the past toward "healthy, athletically tan skin" has continued without interruption for many years. To achieve this goal, people have for many years exposed their skin to the sun because this causes pigment to be formed in a sense of forming melanin. However, the ultraviolet radiation in sunlight also has a damaging effect on skin. In addition to acute damage (sunburn), there is also long-term damage such as an increased risk of developing skin cancer from excessive exposure to light from the UVB range (wavelength 280-320 nm). Excessive exposure to UVB and UVA radiation (wavelength 320-400 nm) also results in a weakening of the elastic and collagen fibers in the connective tissue. This leads to numerous phototoxic and photoallergic reactions and results in premature aging of skin.

Therefore to protect the skin, a number of light protective filter substances that can be used in cosmetic preparations have been developed. These UVA and UVB filters have been summarized in most industrial countries in the form of positive lists such as Annex 7 to the Cosmetic Regulations.

The variety of commercially available sunscreens however must not obscure the fact that these state-of-the-art preparations have a number of disadvantages.

The compound 2-ethylhexyl-2-cyano-3,3-diphenyl acrylate (octocrylene) is a UV filter that is widely used in daily skin care products and sunscreens. In addition to its UV filter properties in the UVB range, this compound is used in particular to stabilize the UVA filter 4-(tert-butyl)-4'-methoxydibenzoylmethane against photochemical degradation. Octocrylene is usually used in combination with other UV filters for example with titanium dioxide.

One disadvantage of the state of the art is the fact that octocrylene in the presence of ethanol usually results in these preparations developing a "bad odor" in the course of their storage as well as after a certain period of time when applied to skin. The resulting odor is remotely reminiscent of the Maggi original seasoning known from the kitchen by the odor of lovage. The cause of this bad odor is the formation of sotolone (3-hydroxy- 4,5-dimethyl-5H-furan-2-one) which has the following structure:

The reaction mechanism leading to the formation of 3-hydroxy-4,5-dimethyl-5H-furan- 2-one (hereinafter referred to as sotolone) is as yet unknown and not understood.

One possibility for avoiding this bad odor is naturally to omit the use of ethanol. However, ethanol is increasingly being used to protect the "preservative-free" cosmetic preparations that are so popular among consumers in order to prevent microbial infestation. In addition, ethanol forms an ideal base for transparent spray preparations, for example, sunscreen sprays, because of its dissolving properties, its sensory properties and its low price.

Therefore, there have been attempts in the state of the art to mask the bad odor of sotolone by using large amounts of perfume substances accordingly. However, this approach has the disadvantage that the perfume substances volatilize out of the preparation over a period of time while the concentration of sotolone increases over the course of time. Furthermore, there is also a growing demand for so-called "perfume-free" preparations, even in the case of cosmetics, in which it is then impossible to mask the odor. A variety of sunscreens which contain micronized titanium dioxide in addition to octocrylene and ethanol are also known in the state of the art. In these cases, titanium dioxides are used, which are partially or entirely present in the anatase crystal structure. For example, the titanium dioxide with the brand name Tego Sun T 805 from Evonik, containing a mixture of the anatase and rutile crystal structures in a ratio of approximately 80:20 may be used. Preparations with titanium dioxide in the anatase crystal structure have the advantage of being more transparent than comparable preparations with titanium dioxide in the rutile crystal structure.

However, one disadvantage of the state of the art is that the preparations containing titanium dioxide in anatase structure have no influence on the formation of the bad odor due to sotolone.

It is an object of the present invention to overcome or ameliorate at least one of the disadvantages of the prior art, or to provide a useful alternative.

It is an object of an especially preferred form of the present invention to develop a cosmetic preparation (in particular a daily skin care product or a sunscreen) containing octocrylene, titanium dioxide and ethanol in which the formation of a bad odor and in particular the formation of sotolone may be suppressed.

Unless the context clearly requires otherwise, throughout the description and the claims, the words "comprise", "comprising", and the like are to be construed in an inclusive sense as opposed to an exclusive or exhaustive sense; that is to say, in the sense of "including, but not limited to".

Although the invention will be described with reference to specific examples it will be appreciated by those skilled in the art that the invention may be embodied in many other forms.

One disadvantage of the state of the art is also the fact that many sunscreens that contain titanium dioxide tend to develop gas bubbles in storage over a longer period of time. This formation of gas (hydrogen) occurs repeatedly even with coated titanium dioxides. Therefore, the object of the present invention was to develop a sunscreen based on micronized titanium dioxide in which the formation of gas during storage would be suppressed effectively.

Summary of the Invention

According to a first aspect of the present invention there is provided a cosmetic preparation containing a) 2-ethyl hexyl-2-cya no-3,3-diphenyl acrylate (octocrylene), b) ethanol and c) titanium dioxide in the rutile crystal structure with a primary particle size of 2-100 nm.

It is preferred according to the invention if the preparation according to the invention contains exclusively titanium dioxide in the rutile crystal structure. According to the invention, a titanium dioxide is present exclusively in the crystal structure if the total amount of other crystal structures does not exceed 1% by weight, based on the total amount of titanium dioxide.

It is preferred according to the invention for the primary particle size of the titanium dioxide according to the invention to be in the range between 5 and 50 nm.

Advantageous embodiments of the present invention according to the invention are characterized in that the titanium dioxide is coated with silica (silicon dioxide and/or silicic acid).

It is preferred according to the invention if the titanium dioxide coated with silica has a layer of dimethicone, simethicone or methicone on the other side of the silica layer (i.e., on the side facing away from the titanium dioxide). Of these substances, dimethicone is especially preferred for use according to the invention.

It is advantageous according to the invention if the secondary particle size of the titanium dioxide in the rutile crystal structure with a primary particle size of 2-100 nm is between 0.05 and 50 pm. The range from 0.1 to 1 pm is preferred according to the invention.

The skilled person can find primary and secondary particle size information in the following literature citation: SCCS/1516/13 Opinion on Titanium Dioxide (Nano Form) Colipa no. S75 from Cosmetics Europe Personal Care Association.

It is advantageous in the sense of the present invention if the preparation contains octocrylene in a concentration of 0.5 to 9.5% by weight, based on the total weight of the preparation. A content of 3 to 9% by weight, based on the total weight of the preparation, is preferred according to the invention.

It is advantageous in the sense of the present invention if the preparation contains ethanol in a concentration of 0.5 to 10% by weight, based on the total weight of the preparation. A content of 4 to 10% by weight, based on the total weight of the preparation is preferred according to the invention.

Advantageous embodiments of the present invention according to the invention are characterized in that the preparation contains the titanium dioxide in the rutile crystal structure with a primary particle size of 2-100 nm in a concentration range from 0.5 to 10% by weight, based on the total weight of the preparation. An amount of 1 to 6% by weight, based on the total weight of the preparation is preferred according to the invention. A cosmetic preparation according to the invention may be present in different forms for example in the form of an emulsion or a hydrodispersion. It is advantageous according to the invention if the preparation is present in the form of an emulsion. It is preferred according to the invention if the preparation is in the form of an O/W emulsion (oil-in-water emulsion).

If A cosmetic preparation according to the invention is in the form of an emulsion (in particular an O/W emulsion) then it is advantageous according to the invention if the preparation contains one or more emulsifiers selected from the group of compounds glyceryl stearate citrate, glyceryl stearate (self-emulsifying), stearic acid, stearate salts, polyglyceryl-3-methylglycose distearate, sodium cetearyl sulfate, sodium stearoyl glutamate, polyglyceryl-10 stearate, cetearyl alcohol, cetearyl sulfosuccinate, potassium cetyl phosphate. According to the invention the emulsifiers glyceryl stearate (self-emulsifying), stearic acid, stearate salts, polyglyceryl-3-methylglycose distearate, sodium cetearyl sulfate, sodium stearoyl glutamate, polyglyceryl-10 stearate, cetearyl sulfosuccinate are preferred.

The total amount of these emulsifiers according to the invention is advantageously from 0.1 to 3% by weight, based on the total weight of the preparation, wherein this total weight corresponds to the individual weight of an emulsifier for the case when only one of these compounds is used in the preparation.

Furthermore according to the invention advantageous embodiments of the present invention are characterized in that the preparation contains one or more alcohols selected from the group of compounds 1,2-propylene glycol, 1,2-butylene glycol, 1,3-butylene glycol, 1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol, 1,2-decanediol, 2-methyl-1,3-propanediol, phenoxyethanol and/or ethyl hexyl glycerol, wherein the use of ethanol, 1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol, 1,2-decanediol, 2-methyl-l,3-propanediol phenoxyethanol and/or ethyl hexyl glycerol is preferred according to the invention. An alternative preferred embodiment with alcohols is the combination of 1,2-propylene glycol, 1,2-butylene glycol and/or 1,3-butylene glycol with 1,2-octanediol.

The total amount of these alcohols according to the invention is advantageous from 0.1 to 5% by weight, based on the total weight of the preparation, wherein this total weight corresponds to the individual weight of an alcohol for the case when only one of these compounds is used in the preparation.

Advantageous embodiments of the present invention are characterized in that the preparation contains one or more UV filters selected from the group of compounds 2-phenylbenzimidazole-5-sulfonic acid and/or the salts thereof; phenylene-l,4-bis-(2-benzimidazyl)-3,3'-5,5'-tetrasulfonic acid salts; l,4-di(2-oxo-10-sulfo-3-bornylidenemethyl)benzene and salts thereof; 4-(2-oxo-3-bornylidenemethyl)benzene sulfonic acid salts; 2-methyl-5-(2-oxo-3-bornylidenemethyl)sulfonic acid salts; 2,2'-methylene-bis-(6-(2H-benzotriazol-2-yl)-4-(l,l,3,3-tetramethylbutyl)phenol); 2-(2H-benzotriazol-2-yl)-4-methyl-6-[2-methyl-3-[l,3,3,3-tetramethyl-l--[(trimethylsilyl)oxy]disiloxanyl]propyl]phenol; 3-(4-methylbenzylidene)camphor; 3- benzylidenecamphor; 4-(tert-butyl)-4'-methoxydibenzoylmethane; terephthalidene dicamphor sulfonic acid; 4-(dimethylamino)benzoic acid (2-ethylhexyl)ester; 4- (dimethylamino)benzoic acid amyl ester; 4-methoxybenzalmalonic acid di(2-ethylhexyl)ester; 4-methoxycinnamic acid isoamyl ester; 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxy-4'-methylbenzophenone; 2,2'-dihydroxy-4-methoxybenzophenone; 2-(4'-diethylamino-2'-hydroxybenzoyl)benzoic acid hexyl ester; homomenthyl salicylate; ethylhexyl salicylate; 2-ethylhexyl-2-hydroxybenzoate; dimethicodiethylbenzalmalonate; 3-(4-(2,2-bis- ethoxycarbonylvinyl)phenoxypropenyl)methoxysiloxane/dimethylsiloxane copolymer; dioctylbutylamidotriazone (INCI: diethylhexyl butamidotriazone); 2.4- bis-{[4-(2-ethylhexyloxy)-2-hydroxy]phenyl}-6-(4-methoxyphenyl)-l,3,5-triazine; 2.4- bis-[5-l-(dimethylpropyl)benzoxazol-2-yl-(4-phenyl)imino]-6-(2-ethylhexyl)imino- 1.3.5- triazine with CAS no. 288254-16-0; 4,4',4"-(l,3,5-triazine-2,4,6-triyltriimino)-tris-benzoic acid-tris(2-ethylhexyl ester) (also: 2,4,6-tris-[anilino-(p-carbo-2'-ethyl-l'-hexyloxy)]-l,3,5-triazine (INCI: ethylhexyl triazone); 2,4,6-tribiphenyl-4-yl-l,3,5-triazine; merocyanines; piperazine derivatives; zinc oxide.

The preparation preferably contains 4-(tert-butyl)-4'-methoxydibenzoylmethane and/or 4-(dimethylamino)benzoic acid (2-ethylhexyl)ester according to the invention.

The total concentration of these two UV filters, which is advantageous according to the invention, amounts to 0.5 to 5% by weight, based on the total weight of the preparation, wherein this total weight corresponds to the single weight for the case when only one of these compounds is used in the preparation.

It is also preferred according to the invention if the preparation contains 2.4.6- tris-[anilino-(p-carbo-2'-ethyl-l'-hexyloxy)]-l,3,5-triazine (INCI: ethylhexyl triazone) and/or 2,4-bis-{[4-(2-ethylhexyloxy)-2-hydroxy]phenyl}-6-(4-methoxyphenyl)-1,3,5-triazine (INCI: bis-ethylhexyloxyphenol methoxyphenyl triazine).

In such a case, the advantageous total concentration of these two UV filters according to the invention is from 0.5 to 8% by weight, based on the total weight of the preparation, wherein this total weight corresponds to the single weight for the case when only one of these compounds is used in the preparation.

It is preferred according to the invention if the preparation according to the invention is free of propylparaben, butylparaben, methylisothiazolinone, chloromethylisothiazolinone, IPBC, DMDM hydantoin, dimethylol glycol, dimethylol urea, sodium hydroxymethyl glycinate, BHT, 3-(4-methylbenzylidene) camphor and 2-hydroxy-4-methoxybenzophenone.

However, advantageous embodiments according to the invention are characterized in that the emulsion contains piroctone olamine (l-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(lH)-pyridone monoethanolamine salt).

If the emulsion contains piroctone olamine, then it is advantageous according to the invention if the piroctone olamine content is from 0.01 to 1% by weight, based on the total weight of the emulsion.

Advantageous embodiments of the present invention are characterized in that the preparation contains one or more oils selected from the group of compounds butylene glycol dicaprylate/dicaprate, phenethyl benzoate,C12-15 alkyl benzoate, dibutyl adipate; diisopropyl adipate; diisopropyl sebacate, dicaprylyl carbonate, di-Ci2-i3 alkyl tartrate, butyloctyl salicylate, diethylhexyl syringylidene malonate, hydrogenated castor oil dimerate, triheptanoin, C12-13 alkyl lactate, C16-17alkyl benzoate, propylheptyl caprylate, caprylic/capric triglyceride, diethylhexyl 2,6-naphthalate, octyldodecanol, caprylic/capric triglyceride, ethylhexyl cocoate.

It is preferred according to the invention if the preparation contains dibutyl adipate, dicaprylyl carbonate and/or C12 to C15 alkyl benzoate.

In addition, the preparation according to the invention may contain the usual lipophilic ingredients known for such preparations for example oils, fats, waxes and the like.

In addition, it is advantageous according to the invention if the preparation contains one or more compounds selected from the group of compounds glycyrrhetinic acid, urea, arctiin, alpha-lipoic acid, folic acid, phytoene, d-biotine, coenzyme Q10, hyaluronic acid, alpha-glucosyl rutin, carnitine, carnosine, caffeine, natural and/or synthetic isoflavo-noids, glyceryl glucose, creatine, creatinine, taurine, β-alanine and/or licochalcone A, panthenol, tocopherol, tocopherol acetate, vitamin C, vitamin C derivatives, glycyrrhiza inflata root extract, polydocanol, magnolol, honokiol, tocopheryl acetate, dihydroxyacetone; 8-hexadecene-l,16-dicarboxylic acid, glyceryl glycose, (2-hydroxyethyl) urea, vitamin E and/or derivatives thereof, hyaluronic acid and/or salts thereof, licochalcone A.

The aqueous phase of the emulsion according to the invention may contain the usual auxiliary cosmetic substances, such as glycerin, electrolytes, self-tanning agents as well as one or more thickeners.

It is preferred according to the invention if the cosmetic preparation is characterized in that the preparation contains 5 to 15% by weight glycerin, based on the total weight of the preparation.

The preparation according to the invention may advantageously contain humectants. Humectants (moisturizers) is the term used for substances or substance mixtures which impart to cosmetic preparations the property of reducing transepidermal water loss (TEWL) after application and/or distribution of the substances on the surface of the skin and/or they have a positive influence on the hydration of the epidermal layer.

Advantageous humectants (moisturizers) in the sense of the present invention include for example glycerin, lactic acid and/or lactates, in particular sodium lactate, butylene glycol, propylene glycol, biosaccharide gum-1, glycine soy, pyrrolidone carboxylic acid and urea. Furthermore, it is advantageous to use polymer moisturizers from the group of water-soluble and/or water-swellable polysaccharides and/or those that can be gelled with the help of water. Advantageous in particular are hyaluronic acid, chitosan and/or a fucose-rich polysaccharide, which appears in the Chemical Abstracts under Register No. 178463-23-5 and is available from the SOLABIA S.A. under the brand name Fucogel® 1000. Moisturizers can also advantageously be used as antiaging ingredients for protection against skin changes, such as those which occur with the aging of skin.

The cosmetic preparations according to the invention may also advantageously, although not necessarily, contain fillers which further improve on the sensory and cosmetic properties of the formulations for example and which bring about or increase a velvet or silky skin feeling. Advantageous fillers in the sense of the present invention include starch and starch derivatives (such as for example tapioca starch, distarch phosphate, aluminum and/or sodium starch octenyl succinate and the like), pigments, which have neither mainly UV filter effects nor coloring effects (such as boron nitride, etc., for example) and/or Aerosils® (CAS no. 7631-86-9) and/or talc and/or polyethylene, nylon, silica dimthyl silylate.

It is preferred according to the invention if the preparation according to the invention contains silica dimethyl silylate.

Furthermore, it is advantageous in the sense of the present invention if the preparation according to the invention contains one or more perfume substances which may advantageously be selected from the group of compounds limonen, citral, linalool, alpha-isomethylionone, geraniol, citronellol, 2-isobutyl-4-hydroxy-4-methyltetrahydropyran, 2-tert-pentylcyclohexyl acetate, 3-methyl-5-phenyl-l-pentanol, 7-acetyl-l,l,3,4,4,6-hexamethyltetraline, adipic acid diester, alpha-amylcinnamaldehyde, alpha-methylionone, amyl C butylphenylmethylpropionalcinnamal, amyl salicylate, amylcinnamyl alcohol, anise alcohol, benzoin, benzyl alcohol, benzyl benzoate, benzyl cinnamate, benzyl salicylate, bergamot oil, bitter orange oil, butylphenylmethylpropional, cardamom oil, cedrol, cinnamal, cinnamyl alcohol, citronellylmethyl crotonate, citrone oil, coumarin, diethyl succinate, ethyl linalool, ethylene brassylate, eugenol, evernia furfuracea extract, evernia prunastri extract, farnesol, guaiac wood oil, hexyl cinnamal, hexyl salicylate, hydroxycitronellal, lavender oil, lemon oil, linayl acetate, mandarin oil, menthyl PCA, methyl heptenone, muscat nut oil, rosemary oil, sweet orange oil, terpineol, tonka bean oil, triethyl citrate and/or vanillin.

The preparation according to the invention advantageously contains according to the invention film-forming agents. Film-forming agents in the sense of the present invention include substances of various compositions characterized by the following property: when a film-forming agent is dissolved in water or other suitable solvents and the solution is applied to skin, it forms a film after evaporation of the solvent which serves essentially to fix light filters on the skin and thereby increase the water resistance of the product.

It is advantageous in particular to select film-forming agents from the group of polymers based on polyvinylpyrrolidone (PVP)

Copolymers of polyvinylpyrrolidone for example the PVP hexadecene copolymer and the PVP eicosene copolymer, which are available from GAF Chemicals Corporation under the brand names Antaron V216 and Antaron V220 are particularly preferred.

Also advantageous are additional polymeric film-forming agents such as, for example, sodium polystyrene sulfonate, which is available from National Starch and Chemical

Corp. under the brand name Flexan 130, and/or polyisobutene, available from Rewo under the brand name Rewopal PIB1000. Other suitable polymers include polyacrylamides (Seppigel 305), polyvinyl alcohols, PVP, PVP/VA copolymers, polyglycols, acrylates/octylacrylamide copolymer (Dermacryl 79), acrylate copolymer (Epitex 66), for example. Use of hydrogenated castor oil dimer dilinoleate (CAS no. 646054-62-8, INCI hydrogenated castor oil dimer dilinoleate), which can be acquired from the company Kokyu Alcohol Kogyo under the name Risocast DA-H or PPG-3 benzyl ether myristate (CAS no. 403517-45-3), which can be obtained from the company Croda Chemicals under the brand name Crodamol STS, is also advantageous.

The preparation according to the invention may advantageously be applied as a cream, lotion, spray or stick-type preparation.

According to the invention, this preparation is used as a daily skin care product or as a sunscreen.

The invention relates not least of all to the use of the titanium dioxide according to the invention in the rutile crystal structure with a primary particle size of 2-100 nm for reducing the bad odor of sotolone in cosmetic preparations containing octocrylene and ethanol as well as the use of the titanium dioxide according to the invention in the rutile crystal structure with a primary particle size of 2-100 nm to reduce the formation of gas in cosmetic preparations containing octocrylene, ethanol and titanium dioxide.

Comparative experiment

With the help of the following comparative experiments, the effect according to the invention could be demonstrated as an example:

Method:

Cosmetic formulations tend to develop the bad odor characteristic of sotolone, depending on the raw material composition. Under intense light exposure, this process can be accelerated and thus a long-term odor stability can be predicted.

The samples to be tested (15 mL in 30 mL glass containers) are irradiated for 60 hours (settings: 765 W/m2, UV filter no. 56052317, coated quartz glass) in a Suntester (Suntest CPLS+, Atlas). This irradiation simulates an intense light exposure.

Next, the odor of the samples is evaluated on a scale of 1 to 6, where 1 = very good and 6 = very poor.

Result:

It can be demonstrated in the cosmetic preparations containing octocrylene and ethanol shown above that long-term odor stability can be achieved only by using the titanium dioxide according to the invention in the rutile crystal structure. A bad odor develops quickly when using titanium dioxide in the anatase crystal structure.

Examples

The following examples should illustrate the present invention without restricting it in any way. All quantitative amounts, percentages and percent amounts are based on the weight and the total amount and/or the total weight of the preparations, unless otherwise indicated.

Although the invention has been described with reference to specific examples it will be appreciated by those skilled in the art that the invention may be embodied in many other forms.

Claims

THE CLAIMS DEFINING THE INVENTION ARE AS FOLLOWS:-

1. A cosmetic preparation containing a) 2-ethylhexyl-2-cyano-3,3-diphenyl acrylate (octocrylene), b) ethanol and c) titanium dioxide in the rutile crystal structure with a primary particle size of 2-100 nm.
2. A cosmetic preparation according to claim 1, wherein the preparation contains exclusively titanium dioxide in the rutile crystal structure.
3. A cosmetic preparation according to any one of the preceding claims, wherein the titanium dioxide is coated with silica.
4. A cosmetic preparation according to claim 3, wherein the titanium dioxide coated with silica has a layer of dimethicone on the exterior side of the silica layer.
5. A cosmetic preparation according to any one of the preceding claims, wherein the preparation contains 2-ethylhexyl-2-cyano-3,3-diphenyl acrylate in a concentration of 0.5 to 9.5% by weight, based on the total weight of the preparation.
6. A cosmetic preparation according to any one of the preceding claims, wherein the preparation contains ethanol in a concentration of 0.5 to 10% by weight, based on the total weight of the preparation.
7. A cosmetic preparation according to any one of the preceding claims, wherein the secondary particle size of the titanium dioxide in the rutile crystal structure with a primary particle size of 2-100 nm is between 0.05 and 50 pm.
8. A cosmetic preparation according to any one of the preceding claims, wherein the preparation contains the titanium dioxide in the rutile crystal structure with a primary particle size of 2-100 nm in a concentration of 0.5 to 10% by weight, based on the total weight of the preparation.
9. A cosmetic preparation according to any one of the preceding claims, wherein the preparation is present in the form of an emulsion.
10. A cosmetic preparation according to any one of the preceding claims, wherein the preparation contains one or more emulsifiers selected from the group of compounds glyceryl stearate citrate, glyceryl stearate (self-emulsifying), stearic acid, stearate salts, polyglyceryl-3-methylglycose distearate, sodium cetearyl sulfate, sodium stearoyl glutamate, polyglyceryl-10 stearate, cetearyl alcohol, cetearyl sulfosuccinate, potassium cetyl phosphate.
11. A cosmetic preparation according to any one of the preceding claims, wherein the preparation contains one or more alcohols selected from the group of compounds 1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol, 1,2-decanediol, 2-methyl-l,3-propanediol, phenoxyethanol and/or ethyl hexyl glycerin.
12. A cosmetic preparation according to any one of the preceding claims, wherein the preparation contains one or more UV filters selected from the group of compounds 2-phenylbenzimidazole-5-sulfonic acid and/or the salts thereof; phenylene-l,4-bis-(2-benzimidazyl)-3,3'-5,5'-tetrasulfonic acid salts; l,4-di(2-oxo-10-sulfo-3-bornylidenemethyl)benzene and salts thereof; 4-(2-oxo-3-bornylidenemethyl)benzene sulfonic acid salts; 2-methyl-5-(2-oxo- 3- bornylidenemethyl)sulfonic acid salts; 2,2'-methylene-bis-(6-(2H-benzotriazol-2-yl)-4-(l,l,3,3-tetramethylbutyl)phenol); 2-(2H-benzotriazol-2-yl)-4-methyl-6-[2-methyl-3-[l,3,3,3-tetramethyl-l--[(trimethylsilyl)oxy]disiloxanyl]propyl]phenol; 3-(4-methyl-benzylidene)camphor; 3-benzylidenecamphor; 4-(tert-butyl)-4'-methoxydibenzoylmethane; terephthalidene dicamphor sulfonic acid; 4-(dimethylamino)benzoic acid (2-ethylhexyl)ester; 4-(dimethylamino)benzoic acid amyl ester; 4-methoxybenzalmalonic acid di(2-ethylhexyl)ester; 4- methoxycinnamic acid isoamyl ester; 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxy-4'-methylbenzophenone; 2,2'-dihydroxy-4-methoxybenzophenone; 2-(4'-diethylamino-2'-hydroxybenzoyl)benzoic acid hexyl ester; homomenthyl salicylate; ethylhexyl salicylate; 2-ethylhexyl-2-hydroxybenzoate; dimethicodiethylbenzalmalonate; 3-(4-(2,2-bis-ethoxycarbonylvinyl)phenoxypropenyl)methoxysiloxane/dimethylsiloxane copolymer; dioctylbutylamidotriazone (INCI: diethylhexyl butamidotriazone); 2,4-bis-{[4-(2-ethylhexyloxy)-2-hydroxy]phenyl}-6-(4-methoxyphenyl)-l,3,5-triazine; 2,4-bis-[5-l-(dimethylpropyl)benzoxazol-2-yl-(4-phenyl)imino]-6-(2-ethylhexyl)imino-l,3,5-triazine with the CAS no. 288254-16-0; 4,4',4"-(l,3,5-triazine-2,4,6-triyltriimino)-tris-benzoic acid-tris(2-ethylhexyl ester) (also: 2,4,6-tris-[anilino-(p-carbo-2'-ethyl-l'-hexyloxy)]-l,3,5-triazine (INCI: ethylhexyl triazone); 2,4,6-tribiphenyl-4-yl-l,3,5-triazine; merocyanines; piperazine derivatives; zinc oxide.
13. A cosmetic preparation according to any one of the preceding claims, wherein the preparation contains 2,4,6-tris-[anilino-(p-carbo-2'-ethyl-l'-hexyloxy)]-l,3,5-triazine (INCI: ethylhexyl triazone) and/or 2,4-bis-{[4-(2-ethylhexyloxy)-2-hydroxy]phenyl}-6-(4-methoxyphenyl)-l,3,5-triazine (INCI: bis-ethylhexyloxyphenol methoxyphenyl triazine).
14. A cosmetic preparation according to any one of the preceding claims, wherein it is free of propylparaben, butylparaben, methylisothiazolinone, chloromethylisothiazolinone, IPBC, DMDM hydantoin, dimethylol glycol, dimethylol urea, sodium hydroxymethyl glycinate, BHT, 3-(4-methyl-benzylidene)camphor and 2-hydroxy-4-methoxybenzophenone.
15. A cosmetic preparation according to any one of the preceding claims, wherein the preparation contains one or more oils selected from the group of compounds butylene glycol dicaprylate/dicaprate, phenethyl benzoate,C12. i5 alkyl benzoate, dibutyl adipate; diisopropyl adipate; diisopropyl sebacate, dicaprylyl carbonate, di-C12-i3 alkyl tartrate, butyloctyl salicylate, diethylhexyl syringylidene malonate, hydrogenated castor oil dimerate, triheptanoin, C12. 13 alkyl lactate, C16-i7 alkyl benzoate, propylheptyl caprylate, caprylic/capric triglyceride, diethylhexyl 2,6-naphthalate, octyldodecanol, caprylic/capric triglyceride, ethylhexyl cocoate.
16. A cosmetic preparation according to any one of the preceding claims, wherein the preparation contains one or more compounds selected from the group of compounds glycyrrhetinic acid, urea, arctiin, alpha-lipoic acid, folic acid, phytoene, d-biotine, coenzyme Q10, hyaluronic acid, alpha-glucosyl rutin, carnitine, carnosine, caffeine, natural and/or synthetic isoflavonoids, glyceryl glucose, creatine, creatinine, taurine, β-alanine and/or licochalcone A, panthenol, tocopherol, tocopherol acetate, vitamin C, vitamin C derivatives, glycyrrhiza inflata root extract, polydocanol, magnolol, honokiol, tocopheryl acetate, dihydroxyacetone; 8-hexadecene-l,16-dicarboxylic acid, glyceryl glycose, (2-hydroxyethyl)urea, vitamin E and/or its derivatives, hyaluronic acid and/or its salts, licochalcone A.