CN117940150A - 用于调控异常基因表达的系统和方法 - Google Patents

用于调控异常基因表达的系统和方法 Download PDF

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Publication number
CN117940150A
CN117940150A CN202280056393.0A CN202280056393A CN117940150A CN 117940150 A CN117940150 A CN 117940150A CN 202280056393 A CN202280056393 A CN 202280056393A CN 117940150 A CN117940150 A CN 117940150A
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target gene
gene
heterologous
cells
krab
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Inventor
亚历山德拉·西尔维·科林德拉赫泰特
曹雯婷
阿比纳夫·阿迪卡里
锡达拉朱·博雷高达
丹尼尔·O·哈特
托马斯·布莱尔·盖努斯
乔瓦尼·卡罗索
杨潇
蒂莫西·戴利
涛·阮·武·隆
刘艳霞
可登宇
安布尔·鲁斯·萨尔兹曼
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Epicrispil Biotechnology Co
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Epicrispil Biotechnology Co
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    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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CN202280056393.0A 2021-06-17 2022-06-16 用于调控异常基因表达的系统和方法 Pending CN117940150A (zh)

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US202163211791P 2021-06-17 2021-06-17
US63/211,791 2021-06-17
PCT/US2022/033797 WO2022266324A1 (en) 2021-06-17 2022-06-16 Systems and methods for regulating aberrant gene expressions

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EP (1) EP4355357A4 (enExample)
JP (1) JP2024523394A (enExample)
KR (1) KR20240032038A (enExample)
CN (1) CN117940150A (enExample)
AU (1) AU2022293494A1 (enExample)
CA (1) CA3221874A1 (enExample)
GB (1) GB2624791A (enExample)
IL (1) IL309174A (enExample)
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN119954926A (zh) * 2025-03-11 2025-05-09 华南农业大学 Klf5转录因子在调控猪骨骼肌发育中的应用及方法
CN119955797A (zh) * 2025-01-13 2025-05-09 江南大学 Kif5b基因在调控成肌细胞生理活性中的功能和应用

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20230076820A (ko) 2020-09-01 2023-05-31 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 진핵생물 유전체 공학을 위한 합성 미니어처 crispr-cas(casmini) 시스템
JP2025507822A (ja) 2022-03-01 2025-03-21 エピクリスパー バイオテクノロジーズ， インコーポレイテッド 組換えヌクレアーゼならびにその組成物および使用方法
CN121127598A (zh) * 2023-03-16 2025-12-12 埃皮克里斯皮尔生物技术公司 用于调控异常基因表达的系统和方法

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EP1107789B1 (en) 1998-08-24 2008-06-25 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for protecting organs, tissue and cells from immune system-mediated damage
EP3443081A4 (en) * 2016-04-13 2019-10-30 Duke University CRISPR / CAS9-BASED REPRESSORS FOR IN VIVO SHUT-OFF OF GEN-TARGETS AND METHOD OF USE
EP3515506B1 (en) * 2016-09-23 2023-09-13 University of Massachusetts Silencing of dux4 by recombinant gene editing complexes
US11160823B2 (en) * 2016-11-07 2021-11-02 University Of Massachusetts Therapeutic targets for facioscapulohumeral muscular dystrophy
US11807877B1 (en) * 2018-03-22 2023-11-07 National Technology & Engineering Solutions Of Sandia, Llc CRISPR/Cas activity assays and compositions thereof
JP2022516515A (ja) * 2018-12-31 2022-02-28 リサーチ インスティチュート アット ネイションワイド チルドレンズ ホスピタル Ｒｎａ標的化ｃｒｉｓｐｒ－ｃａｓ１３ｂを使用するｄｕｘ４ ｒｎａ発現停止
WO2020142739A1 (en) * 2019-01-04 2020-07-09 Mammoth Biosciences, Inc. COMPOSITIONS AND METHODS FOR DETECTING MODIFIED NUCLEIC ACIDS AND AMPLIFYING ssDNA
WO2022133062A1 (en) * 2020-12-16 2022-06-23 Epicrispr Biotechnologies, Inc. Systems and methods for engineering characteristics of a cell

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN119955797A (zh) * 2025-01-13 2025-05-09 江南大学 Kif5b基因在调控成肌细胞生理活性中的功能和应用
CN119954926A (zh) * 2025-03-11 2025-05-09 华南农业大学 Klf5转录因子在调控猪骨骼肌发育中的应用及方法

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KR20240032038A (ko) 2024-03-08
EP4355357A4 (en) 2025-08-20
GB202319324D0 (en) 2024-01-31
AU2022293494A1 (en) 2024-01-04
GB2624791A (en) 2024-05-29
IL309174A (en) 2024-02-01
EP4355357A1 (en) 2024-04-24
JP2024523394A (ja) 2024-06-28
MX2023014750A (es) 2024-03-08
WO2022266324A1 (en) 2022-12-22
CA3221874A1 (en) 2022-12-22
US20240216482A1 (en) 2024-07-04

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