CN117842920A - High-efficiency continuous automatic freezing pipe switch cover filling system - Google Patents

High-efficiency continuous automatic freezing pipe switch cover filling system Download PDF

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Publication number
CN117842920A
CN117842920A CN202410240600.9A CN202410240600A CN117842920A CN 117842920 A CN117842920 A CN 117842920A CN 202410240600 A CN202410240600 A CN 202410240600A CN 117842920 A CN117842920 A CN 117842920A
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China
Prior art keywords
roller
head
unit
frame
freezing
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CN202410240600.9A
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Chinese (zh)
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CN117842920B (en
Inventor
鄢晓君
刘伟
吴新会
徐环叶
张主光
庹福幸
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Shanghai Benyao Technology Co ltd
Beijing Huakan Biotechnology Co ltd
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Shanghai Benyao Technology Co ltd
Beijing Huakan Biotechnology Co ltd
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Priority to CN202410240600.9A priority Critical patent/CN117842920B/en
Publication of CN117842920A publication Critical patent/CN117842920A/en
Application granted granted Critical
Publication of CN117842920B publication Critical patent/CN117842920B/en
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Abstract

The invention relates to a high-efficiency continuous automatic freezing storage tube switch cover filling system which comprises a base, a mounting frame, a freezing storage tube carrier unit, a switch cover unit, a peristaltic pump filling unit, a liquid path unit and a carrier unit driving device, wherein the mounting frame is arranged on one side of the base, and the peristaltic pump filling unit, the liquid path unit and the switch cover unit are arranged on the mounting frame; the switch cover unit comprises a vertical plate, a batch head accommodating frame, a push plate driving device, a plurality of rows of batch head assemblies and a frame driving device; the frame driving device drives the batch head accommodating frame to move up and down on the vertical plate; the push plate is arranged at the lower part of the batch head accommodating frame, and the push plate driving device can drive the push plate to move up and down relative to the batch head accommodating frame.

Description

High-efficiency continuous automatic freezing pipe switch cover filling system
Technical Field
The invention relates to a filling system, in particular to a high-efficiency continuous automatic filling system for a switch cover of a freezing storage tube.
Background
The cell culture process flow requires operations such as liquid adding to the freezing tube for many times, before which the cover needs to be opened, and after the completion, the cover needs to be closed. When the frozen test tube is filled and sealed in a large batch, the efficiency is low, the operation is inconvenient, and meanwhile, the sterility of the filling process is difficult to ensure. Under the operation in batches, the efficiency of manual filling and tube sealing is low, the cell density distribution is uneven, the cell activity is greatly influenced, and the pollution is easily caused in the filling process of the freezing storage tube. The prior art (CN 113083392 a) discloses a freezing tube cap screwing and liquid separating device, which has a first tray 33 and a second tray 34, the first tray 33 is used for placing a bottle cap after unscrewing, and a fixing shaft 37 is provided on a base plate 36 for fixing the freezing tube. It has the following problems: (1) Every time the operation of opening and closing the cover is executed, the cover is required to be placed on the first tray supporting plate 33, and after filling is finished, the cover is required to be lifted from the first tray supporting plate 33, and then the cover closing operation is performed, so that the efficiency is low; (2) The freezing tube usually has a smooth surface, and the length of the freezing tube is long, and if the fixed shaft 37 can not clamp the freezing tube in the process of lifting the cover, the tube body and the cover of the freezing tube can be lifted together easily, so that the operation risk is caused; (3) The bottle cap detecting device 42 has a plurality of sensors, and the number of the bottle cap detecting device is the same as the number of the cap screwing servo motors 44, the more the number of the freezing pipes for one operation (10 in the prior art), the more the number of the sensors is required, the more complicated the bottle cap detecting method is, and the higher the cost is.
Disclosure of Invention
In order to solve the problems, the invention provides a high-efficiency continuous automatic freezing pipe switch cover filling system, which comprises a base, a mounting frame, a freezing pipe carrier unit, a switch cover unit, a peristaltic pump filling unit, a liquid path unit and a carrier unit driving device, wherein the mounting frame is arranged at one side of the base, the peristaltic pump filling unit, the liquid path unit and the switch cover unit are arranged on the mounting frame,
the switch cover unit comprises a vertical plate, a batch head accommodating frame, a push plate driving device, a plurality of rows of batch head assemblies and a frame driving device;
the frame driving device can drive the batch head accommodating frame to move up and down on the vertical plate; the push plate is arranged at the lower part of the batch head accommodating frame, and the push plate driving device can drive the push plate to move up and down relative to the batch head accommodating frame.
Further, the batch head assembly comprises a motor, a driving rod connected with the electrode shaft and a batch head detachably connected with the tail end of the driving rod of the motor; the push plate is provided with a plurality of through holes, and the driving rod passes through the through holes; the diameter of the through hole is smaller than that of the tube cover of the freezing tube.
Further, the switch cover unit further comprises a photoelectric detection device, the photoelectric detection device is arranged at the lower portion of the vertical plate, the photoelectric detection device can emit a beam of light to the column direction where the freezing storage tube is located, the height of the light is consistent with the height where the freezing storage tube cover is located, and the photoelectric detection device judges whether the opening of the cover of the freezing storage tube is completed or not according to the shielding and reflection conditions of the emitted light.
Further, the freezing storage tube carrier unit is detachably fixed on the carrier unit driving device, and the carrier unit driving device can move left and right relative to the base.
Further, the upper surface of the tube cover of the freezing tube is provided with a groove, the batch head is detachably inserted into the groove, and the tube cover clamps the batch head by elastic deformation.
Further, the lower periphery of the head is provided with N first guide surfaces, and the inner periphery of the groove is formed by the following shapes: the vertical projection of the N first guide surfaces forms a polygon, the polygon is slightly reduced inwards by 0.1-1 mm along the periphery to form a reference shape, the reference shape is rotated at least once along the axis of the pipe cover, and the stepping angle of each rotation is alpha, 0< alpha is less than or equal to 180/N; the reference shape and the shape formed after each rotation are overlapped, and the formed outer periphery forms the boundary of the groove, wherein N is more than or equal to 2.
Further, a plurality of first raised strips are arranged on the periphery of the lower part of the batch head, the groove comprises a circular ring matched with the shape of the batch head, a plurality of second raised strips are arranged on the inner periphery of the circular ring, after the batch head is inserted into the groove, the first raised strips are positioned between two adjacent second raised strips, and the inner diameter of the circular ring is slightly smaller than the outer diameter of the batch head by 0.1-1 mm.
Further, the freezing storage pipe carrier unit comprises a carrier frame main body, a spigot plate and a fixed orifice plate; the jack panel is horizontally arranged at the upper part of the carrier frame main body, and a plurality of rows of jacks are arranged on the jack panel; the fixed orifice plate is arranged below the jack orifice plate, and a plurality of rows of containing holes corresponding to the plurality of rows of jack holes are formed in the fixed orifice plate.
Further, the inner wall of the accommodating hole is provided with a plurality of bulges, and gaps between adjacent bulges are used for accommodating a plurality of supporting feet arranged at the periphery of the bottom of the freezing storage tube.
Further, at least one side of the carrier frame body is provided with a plurality of groups of guide grooves positioned at different heights, the guide grooves of each group are arranged in a front-back opposite mode, and the fixed orifice plate is inserted into the carrier frame body through one group of guide grooves.
Further, the carrier unit driving device comprises a sliding block, a dustproof belt, a left supporting frame, a right supporting frame, a left roller and a right roller, and the first roller and the second roller;
the left support frame and the right support frame are respectively and fixedly connected with the left end and the right end of the sliding block, the left roller is positioned in the left support frame and can rotate relative to the left support frame, and the right roller is positioned in the right support frame and can rotate relative to the right support frame;
the first roller is clamped on the left side of the sliding block, the second roller is clamped on the right side of the sliding block, the first roller and the second roller can rotate relative to the sliding block, and the first roller and the second roller are positioned between the left roller and the right roller.
Further, the both ends of base are equipped with first dustproof area fixed plate and second dustproof area fixed plate respectively, and the left end of dustproof area is fixed in the left end of base through first dustproof area fixed plate, then extends to the top of first gyro wheel and second gyro wheel from left gyro wheel below to wear out the back from the below of right gyro wheel, through the right side fixed connection of second dustproof area fixed plate and base.
Further, a slider driving device is arranged in the base and is used for driving the slider to move left and right relative to the base.
The technical scheme of the invention has the following advantages: (1) After the cover of the freezing storage pipe is opened, the pipe cover of the freezing storage pipe is firmly combined with the batch head through elastic deformation, and after the batch head and the cover are lifted, the cover closing operation is directly carried out after the filling of the freezing storage pipe is completed. Compared with the prior art, the pipe cover needs to be placed at other positions, so that the time is greatly saved, and the filling efficiency is improved. In order to ensure that the pipe cover and the batch head can be smoothly separated after the cover is closed, the pipe cover is pressed on the frozen storage pipe cover by downwards moving the push plate, and the push plate can press the pipe cover of the frozen storage pipe to prevent the pipe cover and the batch head from being lifted together because the diameter of the through hole in the push plate is smaller than that of the frozen storage pipe cover; (2) The freezing storage pipe carrier unit is internally provided with a spigot plate and a fixed orifice plate, and the fixed orifice plate can be placed on guide grooves with different heights according to different heights of the freezing storage pipes so as to adapt to the heights of the freezing storage pipes; (3) The slide block is designed to be detachably connected with the carrier frame main body, so that a good freezing pipe can be placed on the carrier frame main body in advance, and the carrier frame main body just after the work is replaced when the filling is needed, and the filling efficiency is greatly improved; (4) The photoelectric detection device can detect the uncovering condition of a row of freezing storage tubes each time, the efficiency is improved by setting the fault tolerance rate for two times, and compared with the prior art, the photoelectric detection device has the advantages that the cost of a detection method and detection equipment is greatly reduced; (5) The dustproof effect is achieved through the special-designed carrier unit driving device.
Drawings
FIG. 1 is a block diagram of a system for filling a freeze tube switch cap of the present invention;
FIG. 2A is a schematic view of a first view of the structure of the switch cover unit of the present invention;
FIG. 2B is a schematic view of a second view of the structure of the switch cover unit of the present invention;
FIG. 3A is a block diagram of a first embodiment of a batch head assembly of the present invention;
FIG. 3B is a partial enlarged view of FIG. 3A
FIG. 3C is a schematic view of a batch head structure of the batch head assembly of FIG. 3A
FIG. 4A is a block diagram of a first embodiment of a vial cap of the present invention;
FIG. 4B is a top view of FIG. 4A;
FIG. 5 is a top view of a second embodiment of a vial cap;
FIG. 6 is a top view of a third embodiment of a vial cap;
FIG. 7 is a block diagram of a second embodiment of a batch head of the present invention; .
FIG. 8 is a block diagram of a fourth embodiment of a vial cap of the present invention;
FIG. 9 is a schematic structural view of a cryoprotectant tube carrier unit according to the present invention;
FIG. 10 is a schematic view of the structure of a drawable orifice plate of the present invention;
FIG. 11 is another block diagram of the freeze tube switch cap filling system of the present invention;
fig. 12 is a schematic structural diagram of a driving device for a carrier unit according to the present invention.
Detailed Description
For convenience of description, the freezing tube carrier unit in fig. 1 translates in the left-right direction, and a plurality of freezing tubes, a head assembly, a filling needle, holes, etc. arranged in the front-rear direction constitute a "column". It will be appreciated by those skilled in the art that the orientation or positional relationship is based on that shown in the drawings, for convenience of description and simplicity of description only, and is not to be taken as an indication or suggestion that the apparatus or elements referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus should not be construed as limiting the invention.
Referring to fig. 1, the high-efficiency continuous automatic freezing storage tube switch cover filling system comprises a base 1, a mounting frame 2, a freezing storage tube carrier unit 3, a switch cover unit 4, a peristaltic pump filling unit 5, a liquid path unit 6, a man-machine interaction unit 7 and a carrier unit driving device 10.
The peristaltic pump filling unit 5, the liquid path unit 6, the switch cover unit 4 and the man-machine interaction unit 7 are arranged on the mounting frame 2. The liquid path unit 6 is used for supplying filling liquid and comprises a liquid pipeline (not shown), a fixed pipe bracket 6-1, a needle bracket 6-2 and a filling needle 6-3. The liquid pipeline is respectively connected with the peristaltic pump canning unit 5 and the filling needles 6-3, the liquid pipeline is supported by the fixed pipe support 6-1, a plurality of filling needles 6-3 are arranged on the needle head support 6-2, and the filling needles 6-3 are arranged in a row along the needle head support. The liquid path unit 6 and the switch cover unit 4 are positioned above the freezing storage pipe carrier unit 3.
The freezing tube carrier unit 3 is detachably fixed on the carrier unit driving device 10, and the carrier unit driving device 10 can move left and right relative to the base. The freezing pipe carrier unit 3 comprises a plurality of rows of jacks 3-21, and the jacks 3-21 are used for inserting freezing pipes 8.
Referring to fig. 2A to 3C, the switch cover unit 4 includes a riser 4-1, a head accommodating frame 4-2, a push plate 4-3, a push plate driving device 4-4, two rows of head assemblies 4-5, a frame driving device 4-6, and a photoelectric detection device 4-7. The frame driving device 4-6 drives the head accommodating frame 4-2 to move up and down on the vertical plate 4-1. The screwdriver bit assembly 4-5 comprises a motor 4-51, a driving rod 4-52 connected with an electrode shaft and a screwdriver bit 4-53 connected with the tail end of the motor driving rod 4-52. The photoelectric detection device 4-7 is arranged at the lower part of the vertical plate 4-1 and is used for detecting whether the tube cover of the freezing tube is opened or not.
The push plate 4-3 is arranged at the lower part of the head accommodating frame 4-2, and the push plate driving device 4-4 can drive the push plate 4-3 to move up and down relative to the head accommodating frame 4-2. The push plate 4-3 is provided with a plurality of through holes, and the driving rod 4-52 passes through the through holes. The diameter of the through hole is smaller than that of the tube cover of the freezing tube.
The basic working process of the filling system is as follows: the empty freezing storage tubes 8 are placed in the insertion holes 3-21 of the freezing storage tube carrier units 3, the freezing storage tube carrier units 3 are fixed on the carrier unit driving device 10, the carrier unit driving device 10 drives the freezing storage tube carrier units 3 to move leftwards, the two rows of freezing storage tubes 8 are aligned with the two rows of batch heads 4-53, the batch head accommodating frames 4-2 move downwards, the batch heads 4-53 are inserted into the corresponding covers 8-1 of the freezing storage tubes 8, and in order to enable the batch heads 4-53 to be accurately inserted into the covers 8-1, the motors 4-51 can drive the batch heads 4-53 to perform micro-motion rotation. After the batch head 4-53 is inserted into the cover 8-1, the motor 4-51 drives the batch head 4-53 to rotate, and meanwhile, the batch head accommodating frame 4-2 moves upwards, so that the uncapping process is finished, namely, uncapping operation is carried out on two rows of freezing pipes 8 each time, and at the moment, the cover 8-1 is clamped on the batch head 4-53;
the freezing pipe carrier unit 3 continues to move leftwards, when the first row of freezing pipes 8 is aligned with the filling needles 6-3, the peristaltic pump filling unit 5 is controlled to inject liquid medicine into the freezing pipes 8, and then the freezing pipe carrier unit 3 continues to move leftwards, and the second row of freezing pipes 8 is aligned with the filling needles 6-3 and is injected with liquid medicine.
Subsequently, the freezing storage pipe carrier unit 3 moves rightwards to the lower part of the cover opening and closing unit 4, the batch head 4-53 is aligned to the freezing storage pipe 8, the batch head accommodating frame 4-2 moves downwards, the motor 4-51 is started to drive the batch head 4-53 to rotate, and the cover on the batch head 4-53 is screwed into the freezing storage pipe; and then stopping the motor 4-51, controlling the batch head accommodating frame 4-2 to move upwards, and simultaneously controlling the push plate 4-3 to move downwards, so that the batch head 4-53 is separated from the cover 8-1 of the freezing storage tube, thereby preventing the freezing storage tube from moving upwards, and completing the cover closing process.
The freezing tube carrier unit 3 continues to move leftwards, and the filling operation of the subsequent freezing tube is completed according to the method.
Compared with the prior art, the method has the advantages that (1) the plurality of head-batch assemblies form a plurality of rows (preferably two rows), and the head-batch assemblies in the plurality of rows can be controlled simultaneously when the cover is opened and closed each time, so that compared with the prior art, the freezing tube filled in unit time is improved in multiple times, and the filling efficiency is greatly improved; (2) After closing the cover, the push plate moves downwards to press the freezing pipe cover, and as the diameter of the through hole in the push plate is smaller than that of the freezing pipe cover, the push plate can press the freezing pipe, so that the freezing pipe is prevented from being driven to move upwards by the batch head when the batch head is separated from the cover of the freezing pipe, and compared with a complex clamp for clamping the freezing pipe in the prior art, the invention is simpler, and the invention can be well suitable for filling a plurality of rows of freezing pipes at one time.
The following describes a process of detecting the uncapping state by the photodetection device 4-7, wherein the photodetection device 4-7 can emit a beam of light 4-71 (for example, infrared ray) in the column direction where the freezing storage tube is located, the height of the light is consistent with the height where the freezing storage tube cover is located, and the photodetection device 4-7 judges whether the uncapping of the column of freezing storage tubes is completed according to the shielding and reflection conditions of the emitted light. When a row of freezing pipes with the uncaps not correctly exist, light rays are blocked, the uncapping failure is primarily judged at the moment, the row of freezing pipes can perform uncapping operation again and then are re-detected, if the uncapping failure still exists, the uncapping failure of the row of freezing pipes is judged, namely, each row of freezing pipes has the fault tolerance of two uncapping failures, and if the uncapping failure of the row of freezing pipes is finally judged, the filling operation is not performed on the row of freezing pipes.
The photoelectric detection device can detect the uncovering condition of a row of freezing storage tubes each time, improves the efficiency by setting the fault tolerance rate for two times, and greatly reduces the cost of the detection method and the detection equipment compared with the prior art.
Fig. 3A to 3C are structural views of a first embodiment of the head according to the present invention, in which a boss 4 to 521 is provided on one side or both sides of a driving rod 4 to 52, and a recess 4 to 531 is provided on an upper end surface of the head 4 to 53 to be fitted with the boss 4 to 521, thereby facilitating positioning of the head. The lower periphery of the head 4-53 is provided with a plurality of first guide surfaces 4-532, the end of the head 4-53 is provided with a fixing hole 4-533, the end of the driving rod 4-52 is provided with a threaded hole (not shown), and a screw is inserted through the fixing hole to be connected with the threaded hole of the driving rod 4-52, thereby fixing the head 4-53 to the driving rod 4-52. Through the mode, the batch heads in different shapes can be replaced, so that the device is suitable for different freezing storage tube covers.
Referring to fig. 4A-4B, there is shown a block diagram of a first embodiment of a freezing cylinder head of the present invention that mates with the first embodiment of the batch head. On the upper surface of the cover 8-1, there is a groove 8-2, and on the inner periphery of the groove 8-2, there is constituted by the following shape: the number of the first guide surfaces 4-532 on the batch head 4-53 is N, the vertical projection of the N first guide surfaces forms a first shape, the first shape is slightly reduced from 0.1 mm to 1 mm along the periphery to the middle to form a reference shape, the reference shape is rotated at least once along the axis of the pipe cover, and the stepping angle of each rotation is alpha, and 0< alpha is less than or equal to 180/N. The reference shape and the shape formed after each rotation thereof are superimposed, and the formed outer periphery forms the boundary of the groove 8-2.
Referring to fig. 3C and 4B, the first guiding surfaces 4-532 are four, and have a vertical projection of about a square, and the reference shape is a slightly reduced square (see dotted line part of fig. 4B), and the reference shape is rotated 45 degrees around the axis of the bottle cap to form a second shape, and the second shape is also a square, and the outer periphery of the overlapped reference shape and second shape forms a decahexagon.
Fig. 5 and 6 show the shape of the inner periphery of the groove 8-2 when the number of the first guide surfaces is 3. The reference shape is triangular, and in fig. 5, the rotation is once, and the rotation angle is 60 degrees. In fig. 6, three rotations of 30 degrees each are performed.
Since the first shape is substantially polygonal, and the boundary of the groove 8-2 is formed by rotating the reference shape to a certain extent, when the head 4-53 moves down to the groove 8-2, the groove 8-2 has a plurality of shapes that can be matched with the periphery of the first guiding surface (for example, in fig. 4B, two squares are actually matched with the first shape formed by the first guiding surface in fig. 3C, two triangles are matched with the first shape in fig. 5, and four triangles are matched with the first shape in fig. 6), so that the head 4-53 can be smoothly inserted into the bottle cap without or only by rotating the head 4-53 by a small angle. In addition, since the reference shape is slightly smaller than the first shape, the cap 8-1 can clamp the bits 4-53 by elastic deformation, and the cap 8-1 can be disengaged from the freezing vial body when the cap is opened.
Through such design for after the frozen storage pipe uncapped, the tube cap of frozen storage pipe firmly combines together through elastic deformation with criticizing the head, criticizes the head and is lifted the back with the lid, waits for frozen storage pipe filling to finish, directly carries out the operation of closing the lid. Compared with the prior art, the pipe cover needs to be placed at other positions, so that the time is greatly saved, and the filling efficiency is improved. In order to be able to smoothly separate the tube cover from the batch head after closing the cover, a push plate is designed, and the push plate moves downwards to press the frozen tube cover.
Fig. 7 is a structural diagram of a second embodiment of the batch head according to the present invention, unlike the first embodiment of the batch head, the lower periphery of the batch head 4-53 is provided with a plurality of first ribs 4-534, the corresponding freezing tube cover is shown in fig. 8, the groove 8-2 comprises a circular ring 8-3 matching the shape of the batch head 4-53, the inner periphery of the circular ring is provided with a plurality of second ribs 8-31, and when the batch head 4-53 is inserted into the groove 8-2, the first ribs 4-534 are located between two adjacent second ribs 8-31. The inner diameter of the circular ring 8-3 is slightly smaller than the outer diameter of the batch head 4-53 by 0.1-1 mm, so that the batch head 4-53 can be clamped by the cover 8-1 in an elastic deformation mode, and the cover 8-1 can be separated from the frozen storage tube body when the cover is opened.
Referring to fig. 9, a schematic structural diagram of a freezing tube carrier unit 3 according to the present invention is shown, where the freezing tube carrier unit 3 includes a carrier frame body 3-1, a receptacle plate 3-2, and a fixing plate 3-3. The jack panel 3-2 is horizontally arranged at the upper part of the carrier frame body 3-1, and a plurality of rows of jacks 3-21 are arranged on the jack panel 3-2. The left side of the carrier frame main body 3-1 is provided with a plurality of groups of guide grooves 3-4 positioned at different heights, and each group of guide grooves are arranged in a front-back opposite mode and used for placing the fixed orifice plates 3-3, and according to the difference of the heights of the freezing pipes, the fixed orifice plates 3-3 can be placed on the guide grooves at different heights so as to adapt to the heights of the freezing pipes.
Referring to fig. 10, the orifice plate 3-3 has a plurality of rows of receiving holes 3-31 corresponding to the plurality of rows of insertion holes 3-21. The inner wall of the accommodating hole 3-31 is provided with a plurality of protrusions 3-32, the periphery of the bottom of the freezing storage tube is provided with a plurality of supporting legs 8-4 (see fig. 4A), when the freezing storage tube 8 is placed in the carrier frame, the tube body of the freezing storage tube passes through the insertion hole 3-21 on the insertion hole plate 3-2, and the protrusions 3-32 on the inner wall of the accommodating hole 3-31 are accommodated in gaps among the plurality of supporting legs 8-4, so that the freezing storage tube can be prevented from excessively rotating when the bottle cap is rotated by the batch head.
Referring to fig. 11-12, the carrier unit driving device 10 includes a slider 10-1, a dust-proof belt 10-2, a left support frame 10-3, a right support frame 10-4, a left roller 10-5, a right roller 10-6, a first roller 10-7, and a second roller 10-8. The slider 10-1 is detachably connected to the carrier frame body 3-1.
The left support frame 10-3 and the right support frame 10-4 are respectively and fixedly connected with the left end and the right end of the sliding block 10-1, the left roller 10-5 is positioned in the left support frame 10-3 and can rotate relative to the left support frame, and the right roller 10-6 is positioned in the right support frame 10-4 and can rotate relative to the right support frame; the first roller 10-7 is clamped at the left side of the sliding block 10-1, the second roller 10-8 is clamped at the right side of the sliding block 10-1, the first roller 10-7 and the second roller 10-8 can rotate relative to the sliding block 10-1, and the first roller 10-7 and the second roller 10-8 are positioned between the left roller and the right roller.
The two ends of the base 1 are respectively provided with a first dustproof belt fixing plate 1-3 and a second dustproof belt fixing plate 1-4, the left end of the dustproof belt 10-2 is fixed at the left end of the base through the first dustproof belt fixing plate 1-3, then extends to the upper parts of the first roller and the second roller from the lower part of the left roller, and is fixedly connected with the right side of the base through the second dustproof belt fixing plate 1-4 after penetrating out from the lower part of the right roller. On the base 1, an elongated slot is arranged between the first dust-proof belt fixing plate 1-3 and the second dust-proof belt fixing plate 1-4 for accommodating a protruding block 10-11 below the slider 10-1, and the protruding block is connected with a slider driving device inside the base 1.
The base has a slider driving device (not shown) therein for driving the slider to move left and right with respect to the base. When the slider moves about for the base, the dustproof belt keeps motionless, and left gyro wheel, right gyro wheel compress tightly the dustproof belt, and gap between left gyro wheel and the base left end, gap between right gyro wheel and the base right-hand member are covered by the dustproof belt to play dirt-proof effect.
In addition, the carrier unit driving device 10 and the freezing pipe carrier unit 3 are designed to be detachably connected, so that a good freezing pipe can be placed on the carrier frame body in advance, and when filling is needed, the carrier frame body just after the work is replaced, and the filling efficiency is greatly improved.
The above embodiments are only for illustrating the technical solution of the present invention, and are not limiting; although the invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical scheme described in the foregoing embodiments can be modified or some technical features thereof can be replaced by equivalents; such modifications and substitutions do not depart from the spirit and scope of the technical solutions of the embodiments of the present invention.

Claims (13)

1. The utility model provides a high-efficient automatic cryopreservation pipe switch lid filling system in succession, includes base (1), mounting bracket (2), cryopreservation pipe carrier unit (3), switch lid unit (4), peristaltic pump filling unit (5), liquid way unit (6), carrier unit drive arrangement (10), one side at base (1) is arranged in mounting bracket (2), peristaltic pump filling unit (5), liquid way unit (6), switch lid unit (4) set up on mounting bracket (2), its characterized in that:
the switch cover unit (4) comprises a vertical plate (4-1), a head accommodating frame (4-2), a push plate (4-3), a push plate driving device (4-4), a plurality of rows of head assembling components (4-5) and a frame driving device (4-6);
the frame driving device (4-6) can drive the batch head accommodating frame (4-2) to move up and down on the vertical plate (4-1); the push plate (4-3) is arranged at the lower part of the batch head accommodating frame (4-2), and the push plate driving device (4-4) can drive the push plate (4-3) to move up and down relative to the batch head accommodating frame (4-2).
2. The system of claim 1, wherein the batch head assembly (4-5) comprises a motor (4-51), a drive rod (4-52) coupled to the electrode shaft, and a batch head (4-53) removably coupled to an end of the motor drive rod (4-52); a plurality of through holes are arranged on the push plate (4-3), and the driving rod (4-52) passes through the through holes; the diameter of the through hole is smaller than that of the tube cover of the freezing tube.
3. The system according to claim 2, wherein the switch cover unit (4) further comprises a photoelectric detection device (4-7), the photoelectric detection device (4-7) is arranged at the lower part of the vertical plate (4-1), the photoelectric detection device (4-7) can emit a beam of light to the column direction where the freezing storage tubes are located, the height of the light is consistent with the height where the freezing storage tube covers are located, and the photoelectric detection device (4-7) judges whether the freezing storage tubes in a column are completely opened according to the shielding and reflection conditions of the emitted light.
4. A system according to any one of claims 1-3, characterized in that the freezer pipe carrier unit (3) is detachably secured to a carrier unit drive means (10), the carrier unit drive means (10) being movable left and right with respect to the base.
5. System according to claim 2, characterized in that the upper surface of the tube cap of the freezing tube is provided with a groove (8-2), the head (4-53) being removably inserted into the groove (8-2), the tube cap clamping the head (4-53) with elastic deformation.
6. The system according to claim 5, characterized in that the lower periphery of the head (4-53) is provided with N first guiding surfaces (4-532), the inner periphery of the groove (8-2) being constituted by the following shapes: the vertical projection of the N first guide surfaces forms a polygon, the polygon is slightly reduced inwards by 0.1-1 mm along the periphery to form a reference shape, the reference shape is rotated at least once along the axis of the pipe cover, and the stepping angle of each rotation is alpha, 0< alpha is less than or equal to 180/N; the reference shape and the shape formed after each rotation thereof are superimposed, and the formed outer periphery forms the boundary of the groove (8-2), wherein N is more than or equal to 2.
7. The system of claim 5, wherein the lower periphery of the head (4-53) is provided with a plurality of first ribs (4-534), the groove (8-2) comprises a circular ring (8-3) matching the shape of the head (4-53), the inner periphery of the circular ring is provided with a plurality of second ribs (8-31), the first ribs (4-534) are located between two adjacent second ribs (8-31) after the head (4-53) is inserted into the groove (8-2), and the inner diameter of the circular ring (8-3) is slightly smaller than the outer diameter of the head (4-53) by 0.1-1 mm.
8. The system according to claim 2, wherein the freezing tube carrier unit (3) comprises a carrier frame body (3-1), a receptacle plate (3-2), a securing plate (3-3); the jack panel (3-2) is horizontally arranged at the upper part of the carrier frame main body (3-1), and a plurality of rows of jacks (3-21) are arranged on the jack panel (3-2); the fixed orifice plate (3-3) is arranged below the jack orifice plate, and a plurality of rows of accommodating holes (3-31) corresponding to the plurality of rows of jack holes (3-21) are formed in the fixed orifice plate.
9. A system according to claim 8, characterized in that the receiving hole (3-31) has a plurality of protrusions (3-32) on its inner wall, the gaps between adjacent protrusions (3-32) being adapted to receive a plurality of support feet (8-4) arranged at the bottom periphery of the freezing tube.
10. The system according to claim 8, characterized in that at least one side of the carrier frame body (3-1) is provided with a plurality of sets of guide grooves (3-4) located at different heights, each set of guide grooves being arranged in a back-and-forth opposite manner, the fixation plate (3-3) being inserted into the carrier frame body (3-1) through one set of guide grooves.
11. The system according to claim 4, wherein the carrier unit driving device (10) comprises a slider (10-1), a dust-proof belt (10-2), a left support frame (10-3), a right support frame (10-4), a left roller (10-5), a right roller (10-6), a first roller (10-7), a second roller (10-8);
the left support frame (10-3) and the right support frame (10-4) are respectively and fixedly connected with the left end and the right end of the sliding block (10-1), the left roller (10-5) is positioned in the left support frame (10-3) and can rotate relative to the left support frame, and the right roller (10-6) is positioned in the right support frame (10-4) and can rotate relative to the right support frame;
the first roller (10-7) is clamped at the left side of the sliding block (10-1), the second roller (10-8) is clamped at the right side of the sliding block (10-1), the first roller (10-7) and the second roller (10-8) can rotate relative to the sliding block (10-1), and the first roller (10-7) and the second roller (10-8) are positioned between the left roller and the right roller.
12. The system according to claim 10, wherein the base (1) is provided with a first dust-proof belt fixing plate (1-3) and a second dust-proof belt fixing plate (1-4) at both ends thereof, and the left end of the dust-proof belt (10-2) is fixed at the left end of the base by the first dust-proof belt fixing plate (1-3), and then extends from below the left roller (10-5) to above the first roller (10-7) and the second roller (10-8), and is fixedly connected to the right side of the base by the second dust-proof belt fixing plate (1-4) after passing out from below the right roller (10-6).
13. A system according to claim 12, characterized in that the base (1) has a slider driving means inside for driving the slider (10-1) to move left and right with respect to the base (1).
CN202410240600.9A 2024-03-04 2024-03-04 High-efficiency continuous automatic freezing pipe switch cover filling system Active CN117842920B (en)

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Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104118835A (en) * 2014-08-07 2014-10-29 苏州百泉信息科技有限公司 Cap opener for screw cap tubes
CN106470913A (en) * 2015-03-22 2017-03-01 神户仿生机械株式会社 Sample packaging container and sample packaging container automated system
CN110540156A (en) * 2019-09-29 2019-12-06 深圳赛动生物自动化有限公司 Stem cell cryopreservation tube cover opening and closing mechanism and working method thereof
CN112573456A (en) * 2020-12-28 2021-03-30 上海电气慧程智能系统有限公司 Intelligent centralized switch cover device for cryopreservation tube
US20210147206A1 (en) * 2018-04-19 2021-05-20 Bd Kiestra B.V. Capper/decapper system and method
CN216336496U (en) * 2021-12-15 2022-04-19 青岛奇点生物有限公司 Full-automatic multichannel spiral is opened and is covered equipment of screwing
CN216890040U (en) * 2022-03-22 2022-07-05 基点生物科技(上海)有限公司 Cover opener for freezing tube
CN115650141A (en) * 2022-11-04 2023-01-31 杭州穆恩自动化科技有限公司 Freeze-stored tube filling and sealing machine capable of automatically screwing and taking cover and operation method thereof
WO2023193746A1 (en) * 2022-04-07 2023-10-12 杭州百伴生物技术有限公司 Multi-channel cap opener
CN220130793U (en) * 2023-06-28 2023-12-05 青岛奇点生物有限公司 Hand-held single-channel cryopreserved tube opening and closing cover device
CN220148408U (en) * 2023-06-02 2023-12-08 广东安达智能装备股份有限公司 Dustproof module, portal frame and intelligent platform system

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104118835A (en) * 2014-08-07 2014-10-29 苏州百泉信息科技有限公司 Cap opener for screw cap tubes
CN106470913A (en) * 2015-03-22 2017-03-01 神户仿生机械株式会社 Sample packaging container and sample packaging container automated system
US20210147206A1 (en) * 2018-04-19 2021-05-20 Bd Kiestra B.V. Capper/decapper system and method
CN110540156A (en) * 2019-09-29 2019-12-06 深圳赛动生物自动化有限公司 Stem cell cryopreservation tube cover opening and closing mechanism and working method thereof
CN112573456A (en) * 2020-12-28 2021-03-30 上海电气慧程智能系统有限公司 Intelligent centralized switch cover device for cryopreservation tube
CN216336496U (en) * 2021-12-15 2022-04-19 青岛奇点生物有限公司 Full-automatic multichannel spiral is opened and is covered equipment of screwing
CN216890040U (en) * 2022-03-22 2022-07-05 基点生物科技(上海)有限公司 Cover opener for freezing tube
WO2023193746A1 (en) * 2022-04-07 2023-10-12 杭州百伴生物技术有限公司 Multi-channel cap opener
CN115650141A (en) * 2022-11-04 2023-01-31 杭州穆恩自动化科技有限公司 Freeze-stored tube filling and sealing machine capable of automatically screwing and taking cover and operation method thereof
CN220148408U (en) * 2023-06-02 2023-12-08 广东安达智能装备股份有限公司 Dustproof module, portal frame and intelligent platform system
CN220130793U (en) * 2023-06-28 2023-12-05 青岛奇点生物有限公司 Hand-held single-channel cryopreserved tube opening and closing cover device

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