CN112573456A

CN112573456A - Intelligent centralized switch cover device for cryopreservation tube

Info

Publication number: CN112573456A
Application number: CN202011581843.7A
Authority: CN
Inventors: 赵国庆; 谢松华; 谢康明; 韩滨旭; 邱学琴
Original assignee: Shanghai Electric Huicheng Intelligent System Co ltd
Current assignee: Shanghai Electric Huicheng Intelligent System Co ltd
Priority date: 2020-12-28
Filing date: 2020-12-28
Publication date: 2021-03-30

Abstract

The invention discloses an intelligent centralized switch cover device for a cryopreservation pipe, wherein a front cabin and a rear cabin of the device are arranged adjacently, a sliding table electric cylinder is arranged at the bottom of the front cabin and the rear cabin and drives the sliding table to move, a lifting electric cylinder is arranged on a partition plate of the front cabin and the rear cabin, a switch mechanism is arranged on the lifting electric cylinder and driven by the lifting electric cylinder to lift, a disinfection filter screen is arranged in the rear cabin and is positioned at a through part of the front cabin and the rear cabin, an exhaust fan and an ultraviolet disinfection lamp are arranged in the rear cabin and are positioned at the inner side of the disinfection filter screen, and a controller is arranged in the rear cabin and is respectively and electrically connected with the sliding table electric cylinder, the switch mechanism; the switch mechanism provides torque for the batch head through the micro motor, the synchronous belt wheel and the synchronous belt, the batch head is pushed to lift through the push rod motor, and the batch head achieves the opening and closing of the cryopreservation pipe through torque and lifting. The device conveniently realizes the centralized opening and closing of the whole plate freezing storage pipe, the cover is reliably sealed, the sample pollution is avoided, the labor intensity of the operation is reduced, and the operation efficiency of opening and closing the cover is improved.

Description

Intelligent centralized switch cover device for cryopreservation tube

Technical Field

The invention relates to the technical field of life science, pharmacy, medical treatment and instruments thereof, in particular to an intelligent centralized cover opening and closing device for a cryopreservation tube.

Background

In the fields of life sciences, pharmacy, medical treatment and apparatus technology, cryopreservation tubes are used as a common vessel for preserving biological samples. Especially in a huge biological sample library, a large amount of biological samples are often processed at a time. The cryopreserved pipe usually adopts the screwed spiral cover to seal, and cryopreserved pipe switch lid is unscrewed or is screwed up by operating personnel manual at present, consequently cryopreserved pipe switch lid becomes a very boring, loaded down with trivial details manual work, and during, the moment of manual screwing up can't guarantee the reliable sealing performance of lid, still has risks such as sample pollution, aerosol propagation. The key is to reduce the labor intensity of opening and closing the cover, improve the operation efficiency and safety, reduce the cost and solve the problem of batch cover opening and closing operation of the frozen pipes

One of the widely used products is the standard cryopreservation tube of the american society for molecular biology (SBS), in which each cell of a 96-cell plate frame is 9mm apart and arranged in 8 rows by 12 columns. The other specification plate frames are enlarged or reduced by integral times according to the distance, and are all called SBS standard arrangement. Although some devices capable of batch processing exist in the market, the covers are basically opened and closed manually or semi-automatically, the market requirements cannot be met, and the research and development of intelligent cover opening and closing devices are imperative.

Disclosure of Invention

The technical problem to be solved by the invention is to provide an intelligent centralized cover opening and closing device for the cryopreservation tube, the device can realize centralized cover opening and closing of the whole plate cryopreservation tube only by simple operation, the cover is reliably sealed, risks such as sample pollution and aerosol propagation are avoided, the labor intensity of operation is reduced, and the cover opening and closing operation efficiency is improved.

In order to solve the technical problem, the intelligent centralized switch cover device for the cryopreservation pipe comprises a sliding table provided with a cryopreservation pipe plate frame, a front cabin, a rear cabin, a sliding table electric cylinder, a switch mechanism, a lifting electric cylinder, a controller, a disinfection filter screen, an exhaust fan and an ultraviolet disinfection lamp, wherein the front cabin and the rear cabin are arranged adjacently, the lower parts of the front cabin and the rear cabin are communicated, the sliding table electric cylinder is arranged at the bottom of the front cabin and the bottom of the rear cabin and drives the sliding table to move to the front cabin or move out of the front cabin, the lifting electric cylinder is arranged on a partition board of the front cabin and the rear cabin, the switch mechanism is arranged on the lifting electric cylinder and is driven by the lifting electric cylinder to realize lifting, the disinfection filter screen is arranged in the through part of the front cabin and the rear cabin, the exhaust fan and the ultraviolet disinfection lamp are respectively arranged in the rear cabin and are arranged on the inner side of the disinfection filter screen, the rear, the controller is arranged in the rear cabin and is respectively electrically connected with the sliding table electric cylinder, the switch mechanism, the lifting electric cylinder, the exhaust fan and the ultraviolet disinfection lamp;

the switch mechanism comprises a lower frame, an upper frame, a push cover plate, a plurality of batch heads, a plurality of synchronous belt wheels, a plurality of synchronous belts, a plurality of torque control clutches, a plurality of micro motors, a push rod motor, a push rod, a screw nut and an upper push plate, wherein the upper frame is arranged on the top surface of the lower frame in the middle, the push cover plate is arranged on the bottom surface of the lower frame in the middle, the plurality of batch heads are arranged on the push cover plate in a row, one end of each torque control clutch is connected with the plurality of batch heads, the other end of each torque control clutch is connected with the plurality of synchronous belt wheels, the plurality of micro motors are arranged on the top surface of the lower frame in a row and are positioned on two sides of the upper frame, the plurality of micro motors are connected with the plurality of synchronous belt, the bottom end of the screw rod is arranged on the top surface of the lower frame through a bearing seat, the screw is screwed on the screw rod, the upper push plate is horizontally arranged on the screw, the push rods are arranged on two sides of the upper push plate, and the bottom ends of the push rods are connected with two sides of the push cover plate through linear bearings.

Further, the device also comprises an operation display screen, wherein the operation display screen is arranged on the front cabin wall and is electrically connected with the controller.

Further, the freezing tube plate frame is a 96-grid plate frame.

Furthermore, in the switch mechanism, the number and the arrangement of the plurality of batch heads are matched with the 96 grid plate frame, the number of the plurality of micro motors is 12, the micro motors are arranged in two groups in a staggered layer, each micro motor drives eight synchronous belt wheels through a synchronous belt, and the eight synchronous belt wheels transmit the torque force to the eight batch heads through the torque control clutch.

Furthermore, a tooth jumping prevention pressure shaft is arranged between each synchronous belt wheel and the synchronous belt.

Further, the torque control clutch comprises an input shaft, an output shaft, an adjusting sleeve, a spring, a connecting ratchet wheel and an engaging sleeve, wherein the adjusting sleeve is connected with the input shaft through threads, the connecting ratchet wheel is arranged at the end part of the input shaft, the spring is sleeved in the input shaft and is positioned between the adjusting sleeve and the connecting ratchet wheel, the engaging sleeve is arranged at the end part of the output shaft, the connecting ratchet wheel is provided with ratchet teeth at intervals along the circumferential direction, the uncovering stress surface of the ratchet teeth is a vertical surface, the closing stress surface of the ratchet teeth is an inclined surface, and the engaging sleeve is provided with notches matched with the ratchet teeth in shape at intervals along the circumferential direction.

The intelligent centralized switch cover device for the cryopreservation tube adopts the technical scheme that a front cabin and a rear cabin of the intelligent centralized switch cover device are arranged adjacently, the lower parts of the front cabin and the rear cabin are communicated, a sliding table electric cylinder is arranged at the bottom of the front cabin and the bottom of the rear cabin and drives the sliding table to move to the front cabin or move out of the front cabin, a lifting electric cylinder is arranged on a partition plate of the front cabin and the rear cabin, a switch mechanism is arranged on the lifting electric cylinder and driven by the lifting electric cylinder to lift, a disinfection filter screen is arranged in the rear cabin and is positioned at the communicated part of the front cabin and the rear cabin, an exhaust fan and an ultraviolet disinfection lamp are arranged in the rear cabin and are positioned at the inner side of the disinfection filter screen, and a controller is arranged in the rear cabin and is respectively; the switch mechanism provides torque for the batch head through the micro motor, the synchronous belt wheel and the synchronous belt, the batch head is pushed to lift through the push rod motor, and the batch head achieves the opening and closing of the cryopreservation pipe through torque and lifting. The device only needs simple operation, can realize the centralized switch cover of the whole plate freezing storage pipe, and the cover is reliably sealed, thereby avoiding the risks of sample pollution, aerosol propagation and the like, reducing the labor intensity of operation and improving the operation efficiency of the switch cover.

Drawings

The invention is described in further detail below with reference to the following figures and embodiments:

FIG. 1 is a schematic diagram of an intelligent centralized cover opening and closing device for a cryopreservation tube according to the present invention;

FIG. 2 is a schematic diagram of a power-on/off mechanism of the present apparatus;

FIG. 3 is a schematic view of the arrangement of the micro motor, the synchronous pulley and the synchronous belt in the device;

FIG. 4 is a schematic diagram of a torque control clutch of the present apparatus;

fig. 5 is an enlarged view of a portion a in fig. 4.

Detailed Description

For example, as shown in fig. 1 and fig. 2, the intelligent centralized switch cover device for the cryopreservation pipe of the invention comprises a slipway 3 provided with a cryopreservation pipe rack 4, a front cabin 1, a rear cabin 12, a slipway electric cylinder 2, a switch mechanism 5, a lifting electric cylinder 7, a controller 8, a disinfection filter screen 11, an exhaust fan 10 and an ultraviolet disinfection lamp 9, wherein the front cabin 1 is arranged adjacent to the rear cabin 12 and the lower part of the front cabin 1 is communicated, the slipway electric cylinder 2 is arranged at the bottom of the front cabin 1 and the rear cabin 12 and drives the slipway 3 to move to the front cabin 1 or move out of the front cabin 1, the lifting electric cylinder 7 is arranged on a partition plate 13 of the front cabin 1 and the rear cabin 12, the switch mechanism 5 is arranged on the lifting electric cylinder 7 and is driven by the lifting electric cylinder 7 to lift, the disinfection filter screen 11 is arranged on the rear cabin 12 and is positioned at the through part of the front cabin 1 and the rear cabin 12, the exhaust fan 10 and the ultraviolet disinfection lamp 9 are, a through hole is arranged on the rear cabin wall provided with the exhaust fan 10, the ultraviolet disinfection lamp 9 is right opposite to the disinfection filter screen 11, and the controller 8 is arranged on the rear cabin 12 and is respectively and electrically connected with the sliding table electric cylinder 2, the switch mechanism 5, the lifting electric cylinder 7, the exhaust fan 10 and the ultraviolet disinfection lamp 9;

the switch mechanism 5 comprises a lower frame 51, an upper frame 52, a push cover plate 53, a plurality of batch heads 54, a plurality of synchronous belt wheels 55, a plurality of synchronous belts 56, a plurality of torque control clutches 57, a plurality of micro motors 58, a push rod motor 59, a push rod 60, a screw rod 61, a screw nut 62 and an upper push plate 63, wherein the upper frame 52 is arranged on the top surface of the lower frame 51 in the middle, the push cover plate 53 is arranged on the bottom surface of the lower frame 51 in the middle, the batch heads 54 are arranged on the push cover plate 53 in rows, one end of the torque control clutches 57 is connected with the batch heads 54 and the other end of the torque control clutches 55, the micro motors 58 are arranged on the top surface of the lower frame 51 and positioned on two sides of the upper frame 52, the micro motors 58 are connected with the synchronous belt wheels 55 through the synchronous belt wheels 56, the push rod motor 59 is arranged on the top surface of the upper frame 52 and an output shaft The bottom end of the screw rod 61 is arranged on the top surface of the lower frame 51 through a bearing seat 65, the screw nut 62 is screwed on the screw rod 61, the upper push plate 63 is horizontally arranged on the screw nut 62, the push rod 60 is arranged on two sides of the upper push plate 63, and the bottom end of the push rod 60 is connected with two sides of the push cover plate 53 through a linear bearing 66.

Preferably, the device further comprises an operation display screen 6, wherein the operation display screen 6 is arranged on the cabin wall of the front cabin 1 and is electrically connected with the controller 8.

Preferably, the freezing tube plate frame 4 is a 96-grid plate frame.

Preferably, as shown in fig. 3, the number and arrangement of the plurality of batch heads 54 in the switch mechanism 5 are matched with the 96-grid rack, the plurality of micro motors 58 are 12 and are arranged in two staggered layers, each micro motor 58 drives eight synchronous pulleys 55 through a synchronous belt 56, and the eight synchronous pulleys 55 transmit torque force to the eight batch heads 54 through the torque control clutch 57.

Preferably, a tooth jump prevention pressure shaft 67 is provided between each timing pulley 55 and the timing belt 56. The synchronous belt is prevented from jumping teeth, and the synchronous belt wheel connected with the screwdriver head is reliably meshed with the synchronous belt.

Preferably, as shown in fig. 4 and 5, the torque control clutch 57 includes an input shaft 571, an output shaft 572, an adjustment sleeve 573, a spring 574, a connection ratchet 575 and an engagement sleeve 576, the adjustment sleeve 573 is connected to the input shaft 571 through a screw, the connection ratchet 575 is disposed at an end of the input shaft 571, the spring 574 is sleeved on the input shaft 571 and is located between the adjustment sleeve 573 and the connection ratchet 575, the engagement sleeve 576 is disposed at an end of the output shaft 572, the connection ratchet 575 is provided with ratchet 577 at intervals in a circumferential direction, a lid opening force receiving surface of the ratchet 577 is a vertical surface, a lid closing force receiving surface is an inclined surface, and the engagement sleeve 576 is provided with notches at intervals in the circumferential direction, the notches having a shape matching with the ratchet 577.

The forebay is for freezing the pipe switch lid cabin of depositing in this device, and the backsbay is aerosol disinfection cabin, and the forebay is equipped with the slip table that bears freezing the pipe grillage, and the slip table is installed on the electric jar below it, can move in and out freezing pipe and grillage from the under-deck, is convenient for freeze putting and taking of depositing pipe grillage. The opening and closing mechanism is arranged above the sliding table in the cabin and plays the roles of opening and closing the cover of the freezing storage pipe. The freezing tube and the plate frame thereof adopt 96 lattices of SBS standard, and can be made into any specification and size according to the requirement. The cover can be opened or closed at one time, and reliable opening and screwing sealing are ensured.

The aerosol disinfection cabin is designed at the rear part of the front cabin, the cabin is divided into an upper part and a lower part, and the middle part is separated by a disinfection filter screen; an air inlet is arranged at the lower part of the disinfection filter screen and below the front cabin partition plate, and an exhaust fan is arranged at the upper part of the disinfection filter screen. A strong ultraviolet lamp for disinfection is arranged above the disinfection filter screen. When the refrigerator is started, the exhaust fan starts to rotate, negative pressure can be formed in the rear cabin according to the principle of hydrodynamics, toxic bioaerosol overflowing when the front cabin freezing pipe is opened can be sucked into the rear cabin, and the toxic bioaerosol is discharged out of the rear cabin after being disinfected by the disinfection filter screen. The filter screen is consumptive disinfection articles for use, need carry out the periodic replacement according to the in service behavior, avoids causing biological danger.

This device is intelligent closed loop sequence control, and the equipment starts the back, and the system can automated inspection switching mechanism whether at the initial point, if lead to its not at the initial point because of reasons such as having a power failure, will automatic re-setting. In the whole process from starting to closing of the equipment, the exhaust fan and the ultraviolet disinfection lamp of the rear cabin are always operated. The device can select different volumes of the freezing tube according to requirements, and then select a button for opening or closing the cover.

Uncovering operation: the cover opening button is pressed, the specification and model of the cryopreserved pipe to be opened are selected, the front cabin door is automatically opened by the system, the sliding table is automatically moved out of the cabin door under the driving of the sliding table electric cylinder, the system prompts an operator to confirm the specification and model of the cryopreserved pipe, the operator places the confirmed plate frame provided with the cover cryopreserved pipe on the sliding table, and after the cover opening button is pressed, the sliding table carries the cryopreserved pipe plate frame to enter the front cabin and align with the switching mechanism, so that the head of the switching mechanism is ensured to be coaxial with the cryopreserved pipe; the system inserts the batch head into the top of the cover through the push rod motor, the batch head and the cover are in interference fit, and the cover can be naturally locked on the batch head due to the elastic action of the cover plastic material, the batch head torque and the cover can be rotated through the micro motor, and the cover slowly rises under the action of the push rod motor, so that the cover is separated from the freezing tube body. The system adopts a photoelectric sensor to detect whether a respective cover is not opened or not; if so, the system gives out sound and light alarm to remind manual intervention. Then the system automatically opens the front cabin door, the sliding table moves out of the cabin door, an operator takes away the cryopreserved pipe without the cover and the plate rack from the sliding table, the cover is left in the opening and closing mechanism, the sliding table is kept in an extending state to wait for closing the cover, and the cover opening operation is completed at the moment.

And (3) closing the cover: pressing and closing the lid button, the system suggestion operator confirms the specification model of cryopreserving the pipe, the operator presses the acknowledgement button, the operator will be equipped with the cryopreserving pipe and the grillage of no lid and place on the slip table, press the lid button again, the slip table will carry cryopreserving pipe and grillage entering front deck, criticize the head automatic rotating lid under micro motor drive, and slowly descend, screw the lid, then the push rod motor drives criticize the head and rise, make the lid take the cryopreserving pipe body to break away from criticize the head, the cryopreserving pipe falls into among the grillage. In the screwing process, under the action of the torque control clutch, the screwing torque of each cover is the same, and the sealing performance is ensured. Then the system automatically opens the front cabin door, the sliding table automatically moves out of the cabin door, an operator takes the cryopreserved pipe and the plate frame away from the sliding table, the sliding table automatically retracts into the cabin door, and the cover closing operation is completed.

When the cover is opened, the system carries out photoelectric sensing detection on the cryopreservation tube and the plate frame entering the front cabin, and if the cryopreservation tube is not covered or the height of the cryopreservation tube is not consistent, the system gives out sound and light alarm and exits from the plate frame. When the cover is closed, the system can also carry out photoelectric sensing detection on the freezing storage tube and the plate frame entering the front cabin, and if the freezing storage tube is provided with a cover or is not consistent in height, the system can also give out an audible and visual alarm and exit the plate frame.

The device is a series of products, and each model can be respectively aiming at 24 grillage, 48 grillage, 96 grillage or other specification grillage which accord with SBS standard, and can select the freezing storage tubes with different heights in each grillage.

Whole switching mechanism accomplishes under the drive of lift electric jar and rises or descends, and when uncapping, whole switching mechanism descends, and the head is aimed at and freezes the pipe, inserts at the first head of wholesale and freezes when depositing the pipe lid top, rotates 30 clockwise earlier, ensures that every wholesale head can both insert the pipe lid reliably in. Then rotates counterclockwise and rises upwards through a push rod motor. The number of turns and the elevation of the counter-clockwise rotation are determined by the thread of the cap of the vial.

The torque control clutch in the device is an important part for opening and closing the cover, when the cover is closed, the cover of the cryopreservation tube is screwed, the torque cannot be too small or too large, the torque cannot be too small and the cryopreservation tube cannot be tightly sealed, and the cryopreservation tube can be damaged too much. One side of a ratchet of a torque control clutch connecting ratchet wheel in the device is an inclined plane, and the other side of the ratchet is a vertical plane. When the cover is opened, the vertical surface of the ratchet is vertical to the stress direction, so that the ratchet cannot slip and break away, enough torsion can be provided, and the cover is ensured to be opened. When the cover is closed, the inclined surface of the ratchet is inclined with the stress direction, and the ratchet cannot slip and break away under the action of the spring, so that certain torque can be transmitted, and the cover is screwed tightly; however, when the tightening resistance is increased, the connecting ratchet wheel can slip and break away and jump the teeth, so that the torque force cannot be transmitted, and the effect of limiting the torque force is achieved. Because the friction coefficient of the material is certain, the aim of controlling the torsion can be achieved by the pressure of the whole spring.

The device can open or close the spiral covers of dozens of cryopreservation tubes on the whole plate at one time, is an intelligent machine and fool operation, has extremely low error rate, can detect and alarm, has high working efficiency, and greatly reduces the labor force of biotechnological personnel; the tightening torque of the cover is controllable and consistent, and reliable sealing is ensured; meanwhile, the sterilization and disinfection function is achieved, and biological poisoning or pollution in the uncovering operation process is avoided.

Claims

1. The utility model provides a be used for freezing to deposit pipe intelligence centralized switch lid device, includes the slip table that is equipped with freezing pipe grillage, its characterized in that: still include front deck, backshell, slip table electric jar, on-off mechanism, lift electric jar, controller, disinfection filter screen, exhaust fan and ultraviolet ray disinfection lamp, the front deck is arranged with the backshell is adjacent and the lower part link up, the slip table electric jar is located front deck and backshell bottom and drive the slip table removes to the front deck or shifts out the front deck, the lift electric jar is located the baffle of front deck and backshell, on-off mechanism locates the lift electric jar and realizes going up and down through the lift electric jar drive, the disinfection filter screen is located the backshell and is located the run-through of front deck and backshell, exhaust fan and ultraviolet ray disinfection lamp are located the backshell respectively and are located disinfection filter screen inboard, and the backshell wall that is equipped with the exhaust fan is equipped with the through-hole, and the ultraviolet ray disinfection lamp is just right the disinfection filter screen, the controller is located the backshell and respectively with slip table electric jar, on-, The exhaust fan is electrically connected with the ultraviolet disinfection lamp;

2. The intelligent centralized switch cover device for the cryopreservation tube of claim 1, wherein: the device also comprises an operation display screen which is arranged on the front cabin wall and is electrically connected with the controller.

3. The intelligent centralized switch cover device for the freezing storage pipe according to claim 1 or 2, which is characterized in that: the freezing tube plate frame is a 96-grid plate frame.

4. The intelligent centralized switch cover device for the cryopreservation tube of claim 3, wherein: the number and arrangement of the plurality of batch heads in the switch mechanism are matched with those of the 96-grid plate frame, the plurality of micro motors are 12 and are distributed in two groups in a staggered layer mode, each micro motor drives eight synchronous belt wheels through a synchronous belt, and the eight synchronous belt wheels transmit torque force to the eight batch heads through the torque control clutch.

5. The intelligent centralized switch cover device for the cryopreservation tube of claim 4, wherein: and a tooth jumping prevention pressure shaft is arranged between each synchronous belt wheel and the synchronous belt.

6. The intelligent centralized switch cover device for the freezing storage pipe according to claim 4 or 5, which is characterized in that: the torque control clutch comprises an input shaft, an output shaft, an adjusting sleeve, a spring, a connecting ratchet wheel and an engaging sleeve, wherein the adjusting sleeve is connected with the input shaft through threads, the connecting ratchet wheel is arranged at the end part of the input shaft, the spring is sleeved in the input shaft and is positioned between the adjusting sleeve and the connecting ratchet wheel, the engaging sleeve is arranged at the end part of the output shaft, the connecting ratchet wheel is provided with ratchet teeth at intervals along the circumferential direction, the uncovering stress surface of each ratchet tooth is a vertical surface, the closing stress surface of each ratchet tooth is an inclined surface, and the engaging sleeve is provided with notches matched with the ratchet teeth in shape at intervals along the circumferential direction.