WO2023083313A1 - Cover opening/closing device and nucleic acid extractor - Google Patents

Abstract

A cover opening/closing device (1) and a nucleic acid extractor. The cover opening/closing device (1) comprises: a mounting frame (10), a clamping mechanism (20), and at least two rotary cover opening mechanisms (30); the clamping mechanism (20) comprises a base (21), a floating seat (22), multiple elastic members (23), and a clamping assembly (24); the base (21) is provided on the mounting frame (10); the floating seat (22) is connected to the base (21); each elastic member (23) is abutted against and connected between the floating seat (22) and the base (21); the clamping assembly (24) is provided on the floating seat (22), and has at least two clamping positions used for clamping a sample tube (a); the at least two rotary cover opening mechanisms (30) are both provided on the mounting frame (10), and are provided in a first direction in a one-to-one corresponding manner to the at least two clamping positions; and each rotary cover opening mechanism (30) is used for clamping a tube cover (b) of the sample tube (a) at the corresponding clamping position and rotating.

Description

Open and close device and nucleic acid extractor

This application refers to the Chinese patent application No. 202220448963.8 submitted on March 2, 2022, entitled "Rotary Uncapping Mechanism, Opening and Opening Device, and Nucleic Acid Extractor", and submitted on November 13, 2021, entitled "Sample Tube Chinese Patent Application No. 202122774014.7 for Clamping Mechanism and Automatic Nucleic Acid Extractor” and No. 202210203438.4 Chinese Patent Application titled “Switch Lid Device and Nucleic Acid Extractor” filed on March 2, 2022, which are incorporated by reference in their entirety incorporated into this application.

technical field

The present application relates to the technical field of biological detection equipment, and more specifically, to a switch cover device and a nucleic acid extractor.

Background technique

The automatic nucleic acid extractor is used to extract nucleic acid from the sample to be tested, and generally includes steps such as opening the cover, pipetting, closing the cover, and extracting. When opening and closing the cover of the sample tube, it is necessary to use two clamping mechanisms to respectively clamp and fix the sample tube and the tube cover. Since the sample tube and the tube cover are connected by threads, the clamping mechanism for clamping the tube cover needs to move along the length direction of the sample tube while the clamping mechanism for clamping the tube cover rotates to open the cover, so that the tube cover is separated from the sample tube.

However, for different sample tubes, the pitch of the thread between it and the tube cover may be different, resulting in the inability to coordinate the moving distance of each clamping mechanism when at least two sample tubes are rotated to open or close the cover at the same time, resulting in inability to Uncap or close at least two sample tubes simultaneously.

Contents of the invention

According to various embodiments of the present application, a nucleic acid extraction and detection device and a nucleic acid extraction and detection method are provided.

A switch cover device, comprising:

Mount;

The clamping mechanism includes a base, a floating seat, a plurality of first elastic members and a clamping assembly, the base is arranged on the mounting frame, the floating seat is movably connected to the base, and each of the first The elastic members are all abutted between the floating seat and the base to provide a pre-tightening force that makes the floating seat move away from the base along the first direction; the clamping assembly is arranged on the on a floating seat with at least two clamping positions for clamping the sample tube; and

At least two rotary cover-opening mechanisms are arranged on the mounting frame, and are arranged in one-to-one correspondence with the at least two clamping positions along the first direction, and each of the rotary cover-opening mechanisms is used for clamping Correspond to the cap of the sample tube in the clamping position and rotate.

In one of the embodiments, the clamping mechanism further includes a guide rod, one of the floating base and the base has guide holes passing through opposite sides thereof along the first direction, and the guide rod can Slidingly passing through the guide hole, and fixedly connected with the other one of the floating seat and the base;

Wherein, there is a first floating gap between the guide hole and the guide rod.

In one of the embodiments, the guide rods include multiple ones, and each of the first elastic members is sleeved on the corresponding guide rods.

In one of the embodiments, the base has a first slide rail extending lengthwise along the first direction, and the floating seat has a first slider slidingly matched with the first slide rail;

Wherein, there is a second floating gap between the first slide rail and the first slider.

In one of the embodiments, the clamping assembly includes a first clamping block and a second clamping block arranged on the floating seat along the second direction, the first clamping block and the second clamping block The at least two clamping positions are formed between the clamping blocks, and at least one of the first clamping block and the second clamping block can be controlled relative to the other along the second direction. approach or distance;

Wherein, the second direction is perpendicular to the first direction.

In one of the embodiments, the clamping assembly further includes a first driving member, a first gear, a first rack and a second rack;

The first driving member is installed on the floating seat, the first gear is installed on the output shaft of the first driving member, the first rack is arranged on the first clamping block, and the The second rack is arranged on the second clamping block;

Both the first rack and the second rack extend lengthwise along the second direction, the first gear is located between the first rack and the second rack, and is connected to the The first rack meshes with the second rack.

In one of the embodiments, the clamping assembly includes a clamping module and a driving module, and the clamping module includes a first clamping block unit and a second clamping block unit arranged on the floating seat along the second direction, At least two clamping positions are formed between the first clamping unit and the second clamping unit; the driving module is arranged on the floating seat and is connected with the first clamping unit Both are drivingly connected with the second clamping block unit, so as to drive the first clamping block unit and the second clamping block unit to approach or move away from each other;

Wherein, the second direction is perpendicular to the first direction.

In one of the embodiments, the driving module includes a driving member and a second screw rod, the driving member is arranged on the floating seat, and is in transmission connection with the second screw rod, so as to drive the second screw rod The rod rotates around its own axis;

The axial direction of the second threaded rod is parallel to the second direction, and has a first threaded segment and a second threaded segment arranged along its axial direction, the threads of the first threaded segment and the second threaded segment The direction of rotation is opposite; the first clamping block unit is screwed to the first threaded segment, and the second clamping block unit is screwed to the second threaded segment.

In one of the embodiments, the first clamping block unit includes a driving block, a first clamping block and a second elastic member, and the second clamping block unit includes a second clamping block;

The driving block and the second clamping block are arranged on the floating seat along the second direction, and the first clamping block is connected to the side of the driving block facing the second clamping block through the second elastic member. On one side, the clamping position is formed between the first clamping block and the second clamping block;

Both the driving block and the second clamping block are in transmission connection with the driving assembly, so that the driving assembly can drive the driving block and the second clamping block to approach or move away from each other.

In one embodiment, a fourth sliding rail extending along the second direction is mounted on the floating seat, and the driving block and the second clamping block are both slidably connected to the fourth sliding rail.

In one embodiment, the first clamping block is slidably connected to the fourth slide rail.

In one of the embodiments, the clamping mechanism further includes a limiter, the limiter includes an opposite fixed end and a stopper end, the fixed end is fixedly connected with the base, and the floating seat Under the action of the pre-tightening force provided by the third elastic member, it can move to the stop position in the direction away from the base; when the floating seat moves to the stop position, the floating seat and the stopper Ends offset.

In one of the embodiments, the floating seat has a through hole, the limiting member includes a rod and a head fixedly connected to one end of the rod, the rod passes through the through hole, the The end of the rod part away from the head is used as the fixed end and is screwed to the base, and the head is used as the stop end and is located on the side of the floating seat away from the base;

Wherein, the outer diameter of the head is larger than the inner diameter of the through hole.

In one of the embodiments, the clamping mechanism further includes a guide module, and the guide module includes a first mounting plate and a second mounting plate;

The first mounting plate is mounted on the floating seat, the second mounting plate is mounted on the base, and one of the first mounting plate and the second mounting plate has a second guide rail, The other one has a guide block; the second guide rail extends along the direction in which the floating base moves relative to the base, and the guide block is slidably connected to the second guide rail.

In one of the embodiments, the base is configured to controllably move relative to the installation frame along a second direction perpendicular to the first direction;

During the movement of the base along the second direction, there is a cover opening and closing position such that each clamping position is opposite to the corresponding rotating cover opening mechanism in the first direction.

In one of the embodiments, during the movement of the base along the second direction, there are also positions for taking and setting out samples and for pipetting;

When the base is at the taking and setting out position or the liquid pipetting position, each of the clamping positions and the corresponding rotating cap opening mechanism are arranged in a misaligned manner in the second direction.

In one of the embodiments, the clamping mechanism further includes a second driving member, a second gear and a third rack;

The second driving member is installed on one of the base and the mounting bracket, the second gear is installed on the output shaft of the second driving member, and the third rack is arranged on the The other one of the base and the installation frame extends lengthwise along the second direction, and the second gear meshes with the third rack.

In one of the embodiments, the switch cover device further includes a lifting mechanism, the lifting mechanism includes a lifting seat and a lifting driving member, and the lifting seat is movably connected to the mounting frame along the first direction, so The at least two rotating cover opening components are all installed on the lifting base; the lifting driving part is installed on the mounting frame and is in transmission connection with the lifting base.

In one of the embodiments, the rotating cover opening mechanism includes:

mount;

A clamping jaw assembly, rotatably connected to the mounting base, for clamping the tube cover;

The driving assembly includes a third driving member installed on the mounting seat, the third driving member is located on the same side of the mounting seat as the jaw assembly, and one end of the third driving member is close to the mounting seat It has a first output shaft, and the first output shaft is in transmission connection with the jaw assembly; the end of the third driving member away from the mounting seat has a second output shaft that rotates synchronously with the first output shaft; and

The origin position detection component includes an inductor and an induction sheet, the induction sheet is installed on the mounting seat, and the induction sheet is installed on the second output shaft; the induction sheet follows the second output shaft During the rotation, the sensing piece can pass by the sensor, and the sensor is used to detect the passing of the sensing piece.

In one of the embodiments, the sensor is connected in communication with the third driving member;

The sensor can control the first output shaft of the third drive member to stop rotating when the sensor detects the sensor plate passing by.

In one of the embodiments, the sensor is a photoelectric switch.

In one of the embodiments, the drive assembly further includes a transmission structure, the transmission structure includes a rotating shaft, the rotating shaft is rotatably connected to the mounting seat, and fixedly connected to the jaw assembly;

The rotating shaft is in transmission connection with the first output shaft, so that the first output shaft can drive the rotating shaft to rotate.

In one of the embodiments, the transmission structure further includes a connecting block fixedly connected to the rotating shaft, and the connecting block is mated with the jaw assembly;

The rotating shaft is integrally formed with the connecting block.

In one of the embodiments, the transmission structure further includes a driving wheel, a driven wheel and a transmission belt, the driving wheel is installed on the first output shaft, the driven wheel is installed on the rotating shaft, and the transmission belt is sleeved Between the driving wheel and the driven wheel.

In one embodiment, the side of the mounting seat facing away from the jaw assembly and the third driving member has a receiving groove, and the driving wheel, the driven wheel and the transmission belt are all accommodated in the receiving groove.

In one of the embodiments, the clamping jaw assembly has a first clamping jaw and a second clamping jaw that can be controlled to approach or move away from each other, and a gap is formed between the first clamping jaw and the second clamping jaw. The clamping position for clamping the tube cover;

Wherein, at least one of the first jaw and the second jaw is equipped with an anti-skid top block facing the other side, and the anti-skid top block is used for being clamped at the clamping position. The tube cover is stopped in a first direction, and the first direction is parallel to the rotation axis of the jaw assembly.

A nucleic acid extractor, comprising a sample tube transfer device, a pipetting device, a nucleic acid extraction device and the above-mentioned switch cover device;

The sample tube transfer device is used to put a sample tube into the clamping position or remove the sample tube at the clamping position, and the pipetting device is used to transfer the sample liquid in the sample tube at the clamping position To the nucleic acid extraction device, the nucleic acid extraction device is used to extract nucleic acid from the sample liquid.

The details of one or more embodiments of the application are set forth in the accompanying drawings and the description below. Other features, objects and advantages of the present application will be apparent from the description, drawings and claims.

Description of drawings

In order to more clearly illustrate the technical solutions in the embodiments of the present application or the prior art, the following will briefly introduce the drawings that need to be used in the description of the embodiments or the prior art. Obviously, the accompanying drawings in the following description are only It is an embodiment of the present application, and those of ordinary skill in the art can also obtain other drawings according to the disclosed drawings on the premise of not paying creative efforts.

Fig. 1 is a schematic structural view of a switch cover device in an embodiment of the present invention;

Fig. 2 is a structural schematic diagram of the clamping mechanism of the switch cover device shown in Fig. 1;

Fig. 3 is the front view of the clamping mechanism shown in Fig. 2;

Fig. 4 is a schematic structural view of the rotary cover opening mechanism of the switch cover device shown in Fig. 1;

Fig. 5 is a front view of the rotary cover opening mechanism shown in Fig. 4;

Fig. 6 is a schematic structural diagram of the clamping assembly and the rotating cover opening mechanism in an embodiment of the present application;

Fig. 7 is a front view of the clamping assembly and the rotary cap opening mechanism shown in Fig. 6;

Explanation of reference numbers:

1. Switch cover device; 10. Mounting frame; 101. First guide rail; 20. Clamping mechanism; 21. Base; 211. First slide rail; 212. Slide seat; 22. Floating seat; 221. First slide Block; 222, the second slide rail; 23, the first elastic member; 24, the clamping assembly; 241, the first clamping block; 2411, the first rack; 2412, the second slider; 242, the second clamping Block; 2421, the second rack; 2422, the third slide block; 243, the first driver; 244, the first gear; 245, the second driver; 246, the second gear; 247, the third rack; 25 , guide rod; 30, rotary cover opening mechanism; 31, mounting seat; 32, jaw assembly; 321, first jaw; 322, second jaw; 323, anti-slip top block; 33, third driving member; 331 , the first output shaft; 332, the second output shaft; 34, the transmission structure; 341, the rotating shaft; 342, the driving wheel; 343, the driven wheel; 344, the transmission belt; 345, the connection block; 35, the conductive slip ring; 40, Origin position detection component; 41, sensor; 42, induction plate; 61, lifting seat; 62, lifting drive member; 63, first screw rod; 64, third slide rail; Four slide rails; 720, clamping module; 721, first clamping block unit; 7211, driving block; 7212, first clamping block; 7213, second elastic member; 722, second clamping block unit; 7221, second clamping Block; 730, driving module; 731, the fourth driving member; 732, the second screw rod; 733, the bearing seat; 760, the limit piece; 761, the rod; 762, the head; A mounting plate; 772, a second mounting plate; 773, a second guide rail; 774, a guide block.

Detailed ways

In order to make the above-mentioned purpose, features and advantages of the present application more obvious and understandable, the specific implementation manners of the present application will be described in detail below in conjunction with the accompanying drawings. In the following description, numerous specific details are set forth in order to provide a thorough understanding of the application. However, the present application can be implemented in many other ways different from those described here, and those skilled in the art can make similar improvements without departing from the connotation of the present application, so the present application is not limited by the specific embodiments disclosed below.

In the description of the present application, it should be understood that the terms "center", "longitudinal", "transverse", "length", "width", "thickness", "upper", "lower", "front", " Back", "Left", "Right", "Vertical", "Horizontal", "Top", "Bottom", "Inner", "Outer", "Clockwise", "Counterclockwise", "Axial" , "radial", "circumferential" and other indicated orientations or positional relationships are based on the orientations or positional relationships shown in the drawings, and are only for the convenience of describing the application and simplifying the description, rather than indicating or implying the referred device or Elements must have certain orientations, be constructed and operate in certain orientations, and thus should not be construed as limiting the application.

In addition, the terms "first" and "second" are used for descriptive purposes only, and cannot be interpreted as indicating or implying relative importance or implicitly specifying the quantity of indicated technical features. Thus, the features defined as "first" and "second" may explicitly or implicitly include at least one of these features. In the description of the present application, "plurality" means at least two, such as two, three, etc., unless otherwise specifically defined.

In this application, terms such as "installation", "connection", "connection" and "fixation" should be interpreted in a broad sense, for example, it can be a fixed connection or a detachable connection, unless otherwise clearly specified and limited. , or integrated; it may be mechanically connected or electrically connected; it may be directly connected or indirectly connected through an intermediary, and it may be the internal communication of two components or the interaction relationship between two components, unless otherwise specified limit. Those of ordinary skill in the art can understand the specific meanings of the above terms in this application according to specific situations.

In the present application, unless otherwise clearly specified and limited, a first feature being "on" or "under" a second feature may mean that the first and second features are in direct contact, or that the first and second features are indirect through an intermediary. touch. Moreover, "above", "above" and "above" the first feature on the second feature may mean that the first feature is directly above or obliquely above the second feature, or simply means that the first feature is higher in level than the second feature. "Below", "beneath" and "beneath" the first feature may mean that the first feature is directly below or obliquely below the second feature, or simply means that the first feature is less horizontally than the second feature.

It should be noted that when an element is referred to as being “fixed on” or “disposed on” another element, it may be directly on the other element or there may be an intervening element. When an element is referred to as being "connected to" another element, it can be directly connected to the other element or intervening elements may also be present. As used herein, the terms "vertical", "horizontal", "upper", "lower", "left", "right" and similar expressions are for the purpose of illustration only and are not intended to represent the only embodiments.

Referring to FIG. 1 , FIG. 2 and FIG. 3 , an embodiment of the present invention provides a cover opening device 1 , which includes a mounting frame 10 , a clamping mechanism 20 and a rotating cover opening mechanism 30 .

The clamping mechanism 20 includes a base 21 , a floating base 22 , a first elastic member 23 and a clamping assembly 24 . The base 21 is arranged on the mounting frame 10 , and the floating seat 22 is movably connected to the base 21 . Each first elastic member 23 abuts between the floating seat 22 and the base 21 to provide a pre-tightening force that makes the floating seat 22 move away from the base 21 along the first direction X. The clamping assembly 24 is disposed on the floating base 22 so as to float relative to the base 21 together with the floating base 22 . The clamping assembly 24 has at least two clamping positions (not marked) for clamping the sample tube a.

The rotating cap opening mechanism 30 includes at least two, and both are arranged on the mounting frame 10 . The at least two rotating cap opening mechanisms 30 are arranged in a one-to-one correspondence with the above-mentioned at least two clamping positions in the first direction X. Each rotary cap opening mechanism 30 is used to clamp the tube cap b of the sample tube a corresponding to the clamping position, and rotate to realize cap opening or closing.

In the above-mentioned cover opening and closing device 1, during the actual operation of opening and closing the cover, the clamping assembly 24 clamps the sample tube a in each clamping position, and each rotary cover opening mechanism 30 clamps the tube cover b on the sample tube a in the corresponding clamping position , and rotate to open or close the cover. In the process of rotating and opening and closing the caps of each rotary cap-opening mechanism 30, since the sample tube a and the tube cap b are threadedly connected, the sample tube a will move away from or approach the tube along the first direction X direction under the action of the tube cap b. The direction of the cover b moves (that is, it moves away from the tube cover b when the cover is opened, and moves in the direction close to the tube cover b when the cover is closed), and then drives the floating seat 22 to float (the first elastic member 23 is deformed), until the completion Open or close the cover.

In this way, since the floating seat 22 can be deformed and floated by the first elastic member 23, when the pitch of the sample tube a in each clamping position is different, the first clamping position corresponding to the different clamping position will be rotated in the process of opening or closing the cover. An elastic member 23 produces different deformation amounts, that is, the floating seat 22 produces different floating amounts corresponding to different clamping positions, so as to adapt to the movement amount between each sample tube a and the tube cover b, and finally realize the displacement of each sample tube a. Open or close the cover at the same time.

In the embodiment of the present invention, the clamping mechanism 20 further includes a guide rod 25 . One of the floating seat 22 and the base 21 has guide holes extending through opposite sides thereof along the first direction X. The guide rod 25 is slidably passed through the guide hole, and is fixedly connected with the other one of the floating base 22 and the base 21 . Wherein, there is a first floating gap between the guide hole and the guide rod 25 . In this way, the setting of the guide hole and the guide rod 25, on the one hand, through the relative sliding of the guide rod 25 and the guide hole, plays a role in guiding the floating seat 22 to float up and down in the first direction X with respect to the base 21; on the other hand , due to the existence of the first floating gap, when at least two sample tubes a are opened or closed at the same time, the floating amount of the floating seat 22 along the first direction X at the position corresponding to different clamping positions is allowed to be different (For example, in the embodiment shown in Figure 3, assuming that the pitch of the sample tube a on the left side is greater than the pitch of the sample tube a on the right side, in the process of closing the caps of the left and right sample tubes a at the same time, it is allowed to float The upward floating amount on the left side of the seat 22 is greater than the upward floating amount on the right side, that is, the floating seat 22 is in a tilted state with the left side high and the right side low), which is conducive to smoothly opening or closing at least two sample tubes a at the same time.

It should be noted that, due to the small difference in the pitch of each sample tube a, during the process of uncapping or closing at least two sample tubes a at the same time, the inclination angle of the floating seat 22 is small, which will not affect the floating position. Clamping assembly 24 etc. on the seat 22.

Specifically, in the embodiment shown in FIGS. 1 to 3 , the guide hole is opened on the floating seat 22, the guide rod 25 is passed through the guide hole on the floating seat 22, and the end of the guide rod 25 facing the base 21 is fixed to the base 21. connected, so that the floating seat 22 can float along the guide rod 25.

In specific embodiments, the guide rods 25 may include multiple guide rods, that is, multiple guide rods 25 are arranged between the floating seat 22 and the base 21 . Each first elastic member 23 is respectively sleeved on the corresponding guide rod 25, and the opposite ends of each first elastic member 23 respectively abut against the floating seat 22 and the base 21, so that the first elastic member 23 can be guided along the The telescopic deformation of the rod 25 means that the deformation of the first elastic member 23 is guided by the guide rod 25 , so that the deformation process of the first elastic member 23 is more stable and reliable. Optionally, the first elastic member 23 may be a spring.

Specifically, in the embodiment, a plurality of guide rods 25 are arranged at intervals along the edge of the floating seat 22, so that the floating seat 22 is more stable and reliable during the floating process. For example, when the floating seat 22 is rectangular, a guide rod 25 is arranged at each of the four corners of the rectangle.

In the embodiment of the present invention, the base 21 has a first slide rail 211 extending lengthwise along the first direction X. As shown in FIG. The floating seat 22 has a first sliding block 221 slidingly matched with the first sliding rail 211 . Wherein, there is a second floating gap between the first sliding rail 211 and the first sliding block 221 . In this way, on the one hand, the sliding of the first slider 221 along the first slide rail 211 is used to guide the floating of the floating seat 22 relative to the base 21 along the first direction X; on the other hand, due to the existence of the second floating gap, So that when at least two sample tubes a are opened or closed at the same time, the floating seat 22 is allowed to have a difference in the floating amount along the first direction X at the position corresponding to different clamping positions, which is conducive to smoothly simultaneously testing at least two sample tubes a. Each sample tube a is opened or closed.

In the embodiment of the present invention, the clamping assembly 24 includes a first clamping block 241 and a second clamping block 242, and the first clamping block 241 and the second clamping block 242 are arranged on the floating seat 22 along the second direction Y above, and the above-mentioned at least two clamping positions are formed between the two. At least one of the first clamping block 241 and the second clamping block 242 can be controlled to approach or move away from the other along the second direction Y, so as to clamp or loosen the sample tube a at each clamping position . Wherein, the second direction Y is perpendicular to the first direction X. In this way, each sample tube a is respectively placed on each clamping position, and the first clamping block 241 and the second clamping block 242 approach each other to clamp each sample tube a. Then, the tube cap b on the corresponding sample tube a is clamped by each rotary cap opening mechanism 30, and the cap is rotated to open or close the cap.

Further, the surface of the first clamping block 241 facing the second clamping block 242 is provided with at least two first grooves (not shown in the figure), and the surface of the second clamping block 242 facing the first clamping block 241 is provided with At least two second grooves (not shown in the figure), each first groove and each second groove are arranged opposite to each other in the second direction Y. Each group forms one above-mentioned clamping position between the first groove and the second groove facing in the second direction Y.

Further, the first clamping block 241 has a first elastic portion on a side facing the second clamping block 242 , and the at least two first grooves are provided on the surface of the first elastic portion facing the second clamping block 242 . A side of the second clamping block 242 facing the first clamping block 241 has a second elastic portion, and the above-mentioned at least two second grooves are provided on a surface of the second elastic portion facing the first clamping block 241 . In this way, using the deformability of the first elastic part and the second elastic part, on the one hand, it plays a buffer role when clamping the sample tube a, so as to avoid pinching the sample tube a; Clamping at the same time (the difference in pipe diameter should not be too large), is conducive to the compatibility of the lifting device. Optionally, both the first elastic part and the second elastic part can be made of elastic materials such as rubber, which is not limited here.

Specifically in the embodiment, the clamping assembly 24 further includes a first driving member 243 , a first gear 244 , a first rack 2411 and a second rack 2421 . The first driving member 243 is installed on the floating base 22 , and the first gear 244 is installed on the output shaft of the first driving member 243 to rotate synchronously with the output shaft of the first driving member 243 . The first rack 2411 is disposed on the first clamping block 241 , and the second rack 2421 is disposed on the second clamping block 242 . Both the first rack 2411 and the second rack 2421 extend lengthwise along the second direction Y, the first gear 244 is located between the first rack 2411 and the second rack 2421, and is connected to the first rack 2411 and the second rack. The rack 2421 meshes. In this way, when the output shaft of the first driving member 243 rotates, the first clamping block 241 and the second clamping block 242 are close to each other through the transmission of the first gear 244 and the first rack 2411 and the second rack 2421 , until the sample tube a of each clamping position is clamped; when it is necessary to loosen the sample tube a of each clamping position, the output shaft of the first driving member 243 rotates in the opposite direction, thereby through the first gear 244 and the first rack 2411 and the transmission of the second rack 2421 make the first clamping block 241 and the second clamping block 242 away from each other until the sample tube a at each clamping position is released. Optionally, the first driving member 243 may be a motor.

It should be noted that, in this embodiment, the rack and pinion transmission structure 34 is used to realize the approaching or moving away of the first clamping block 241 and the second clamping block 242 . Certainly, in some other embodiments, other transmission structures 34 may also be used, such as a cam transmission structure 34 , a cylinder transmission structure 34 , a lead screw transmission structure 34 , etc., which are not limited here.

Specifically in the embodiment, the floating seat 22 is provided with a second sliding rail 222 extending longitudinally along the second direction Y, the first clamping block 241 is provided with a second sliding block 2412 , and the second clamping block 242 is provided with a There is a third slider 2422. The second sliding block 2412 is slidingly matched with the second sliding rail 222 , so that the movement of the first clamping block 241 along the second direction Y is guided by the sliding of the second sliding block 2412 along the second sliding rail 222 . The third sliding block 2422 is slidingly matched with the second sliding rail 222 , so that the movement of the second clamping block 242 along the second direction Y is guided by the sliding of the third sliding block 2422 along the second sliding rail 222 . In this way, the arrangement of the second slide block 2412, the third slide block 2422 and the second slide rail 222 makes the movement of the first clamping block 241 and the second clamping block 242 close to or away from each other more stable and reliable, thus smoother and more accurate Clamp or loosen the sample tube a at each clamping position.

In the embodiment of the present invention, the base 21 is configured to controllably move relative to the installation frame 10 along a second direction Y perpendicular to the first direction X. During the movement of the base 21 along the second direction Y, there is a switch cover position (as shown in FIG. 1 ). They are opposite in one direction X, so that each rotating cover opening mechanism 30 clamps the tube cover b on the sample tube a corresponding to the clamping position, and rotates to complete the cover opening or closing operation. In this way, when the cover needs to be opened or closed, the control base 21 moves to the cover opening position along the second direction Y, so that each rotating cover opening mechanism 30 performs the cover opening or closing operation. After the opening and closing actions are completed, the control base 21 moves along the second direction Y away from the opening and closing position, so as to replace the sample tube a on each clamping position.

Further, during the movement of the base 21 along the second direction Y, there are also positions for sampling and setting out and for pipetting. When the base 21 is at the position of taking samples or pipetting, each clamping position and the corresponding rotary cap opening mechanism 30 are arranged in a misalignment in the second direction Y, so that there is enough operating space for changing the sample tube a or pipetting action, to avoid the rotation of the cap opening mechanism 30 from interfering with the replacement of the sample tube a or the pipetting action. In this way, during actual operation, firstly, the control base 21 moves to the position of sampling and setting out along the second direction Y, so that the sample tube a is placed at each clamping position, and the first clamping block 241 and the second clamping block 242 are clamped Individual sample tubes a. Then, the control base 21 moves along the second direction Y to the opening and closing position, and each rotating cap opening mechanism 30 respectively clamps the tube cap b on the corresponding sample tube a, and rotates to complete the cap opening. Then, the control base 21 moves to the pipetting position along the second direction Y, so that the sample in each sample tube a is pipetted by the pipetting device. After the pipetting is completed, the control base 21 moves to the position of opening and closing the cover again along the second direction Y, and each rotating cover opening mechanism 30 respectively screws the clamped tube cover b to the corresponding sample tube a, that is, the closing of the cover is completed. Then, the control base 21 moves to the setting-out position again along the second direction Y, and the first clamping block 241 and the second clamping block 242 are away from each other, thereby loosening the sample tube a at each clamping position, so that the clamping The tight sample tube a is removed, and the sample tube a that needs to be pipetted is placed on each clamping position again, and the operations of opening, pipetting and closing the cover are performed again according to the above steps. Preferably, the taking and setting out position, the switch cover position and the pipetting position are sequentially arranged at intervals along the second direction Y, that is to say, the switch cover position is located between the taking and setting out position and the liquid pipetting position, which is conducive to optimizing the transfer of the following sample tubes Spatial arrangement of devices and pipetting devices, etc.

Specifically in the embodiment, the clamping mechanism 20 further includes a second driving member 245 , a second gear 246 and a third rack 247 . The second driving member 245 is installed on one of the base 21 and the mounting frame 10 , and the second gear 246 is installed on the output shaft of the second driving member 245 to rotate synchronously with the output shaft of the second driving member 245 . The third rack 247 is disposed on the other one of the base 21 and the mounting frame 10 , and extends lengthwise along the second direction Y. The second gear 246 meshes with the third rack 247 . In this way, the output shaft of the second driving member 245 rotates, thereby driving the base 21 to move in the second direction Y relative to the mounting bracket 10 through the second gear 246 and the third rack 247 . Specifically, in the embodiment shown in FIGS. 1 to 3 , the second driving member 245 is installed on the base 21 , and the third rack 247 is installed on the mounting frame 10 . Optionally, the second driving member 245 may be a motor.

Specifically in the embodiment, the installation frame 10 is provided with a guide rail 101 , and the guide rail 101 extends lengthwise along the second direction Y. The base 21 is provided with a sliding seat 212 , and the sliding seat 212 is slidingly matched with the guide rail 101 . In this way, the movement of the base 21 relative to the installation frame 10 along the second direction Y is guided by the sliding of the sliding seat 212 along the guide rail 101 .

In the embodiment of the present invention, the switch cover device 1 further includes a lifting mechanism (not shown in the figure), and the lifting mechanism includes a lifting seat 61 and a lifting driving member 62 . The lifting base 61 is movably connected to the mounting frame 10 along the first direction X, and the above-mentioned at least two rotating cover opening mechanisms 30 are mounted on the lifting base 61 to move along the first direction X together with the lifting base 61 . The lifting driving member 62 is mounted on the mounting frame 10 and is in transmission connection with the lifting base 61 to drive the lifting base 61 to move along the first direction X.

In this way, when the cover needs to be opened, the control base 21 moves to the switch cover position along the second direction Y, and then the lifting drive member 62 drives the lifting seat 61 to move close to the clamping assembly 24 along the first direction X (that is, as shown in FIG. 1 downward movement), so that each rotary capping mechanism 30 is close to the sample tube a corresponding to the clamping position, so that each rotary capping mechanism 30 can clamp the cap b on the sample tube a corresponding to the clamping position. After each rotary cap opening mechanism 30 respectively clamps the corresponding tube cap b, each rotary cap opening mechanism 30 rotates respectively until the cap opening is completed. Finally, the lifting driver 62 drives the lifting base 61 to move away from the clamping assembly 24 along the first direction X (ie upward as shown in FIG. 1 ), so that the tube cover b is completely separated from the sample tube a. When it is necessary to close the cover, the control base 21 moves to the switch cover position along the second direction Y, and then the lifting drive member 62 drives the lifting seat 61 to move close to the clamping assembly 24 along the first direction X until each rotary cover opening mechanism 30 clamps The held tube cap b pushes the corresponding sample tube a to move along the first direction X (compresses each first elastic member 23 at this time), until each first elastic member 23 produces a certain amount of compression. Then, each rotary cap opening mechanism 30 rotates until the cap closing is completed (the compression amount of each first elastic member 23 gradually decreases during the cap closing process, and the floating seat 22 gradually floats close to the rotary cap opening mechanism 30 along the first direction X) . Finally, each rotary cap opening mechanism 30 respectively releases the corresponding tube cap b, and the lifting drive member 62 drives the lifting seat 61 to move away from the clamping assembly 24 along the first direction X until each rotary cap opening mechanism 30 is respectively connected to the corresponding tube cap b. Cover b separates.

It should be noted that the lifting drive member 62 can be used to drive the lifting base 61 to move along the first direction, thereby adjusting the height of the rotary cover opening mechanism 30 relative to the clamping mechanism 20, so as to be suitable for sample tubes a of different heights, and further enhance the compatibility of the device. sex.

It should also be noted that in the prior art, it is necessary to use a manipulator to control the rotation of the cover opening mechanism 30 to move in multiple directions (such as the horizontal direction and the up and down directions), resulting in a large cumulative error in the movement of the rotation cover opening mechanism 30, and the successful opening and closing of the cover. The rate is lower. However, in this application, it is only necessary to control the movement of the rotary cover opening mechanism 30 along the first direction X (ie, the up and down direction) through the lifting mechanism, which reduces the cumulative error of the rotary cover opening mechanism 30 movement and is beneficial to improve the success rate of opening and closing the cover.

Specifically in the embodiment, the lifting mechanism further includes a screw 63 and a screw nut (not shown). The threaded rod 63 is in transmission connection with the lifting driving member 62 so as to be driven by the lifting driving member 62 to rotate around its own axis, and the axis of the threaded rod 63 is parallel to the first direction X. The screw nut is fixedly connected to the lifting base 61 and is threadedly connected with the screw rod 63 , so that when the screw rod 63 rotates around its own axis, the screw nut can drive the lifting base 61 to move along the first direction X. In this way, when each rotary cap opening mechanism 30 needs to move along the first direction X, the lifting drive member 62 drives the screw 63 to rotate around its own axis, thereby driving the lifting base 61 to move along the first direction X through the screw nut, thereby making the installation All the rotary cap opening mechanisms 30 on the lifting base 61 move together along the first direction X. Optionally, the lift driving member 62 may be a motor.

Specifically, in the embodiment, the installation frame 10 is provided with a third slide rail 64 , and the third slide rail 64 extends lengthwise along the first direction X. As shown in FIG. A fourth sliding block 65 is disposed on the lifting base 61 , and the fourth sliding block 65 is slidingly matched with the third sliding rail 64 . In this way, the sliding of the fourth slide block 65 along the third slide rail 64 is used to guide the movement of the lifting base 61 along the first direction X relative to the mounting frame 10, so that the movement of each rotary cover opening mechanism 30 along the first direction X is more accurate. Accurate and stable.

Please refer to Fig. 1, Fig. 4 and Fig. 5, in the embodiment of the present invention, each rotary cap opening mechanism 30 includes a mounting seat 31, a jaw assembly 32, a driving assembly (not shown in the figure) and an origin detection assembly 40. The mounting base 31 is fixedly installed on the lifting base 61, and the jaw assembly 32 is rotatably connected to the side of the mounting base 31 facing the clamping assembly 24. The clamping jaw assembly 32 is used to clamp the tube of the sample tube a at the clamping position. cover b.

The driving assembly includes a third driving member 33 installed on the mounting base 31, and the third driving member 33 is located on the same side of the mounting base 31 as the jaw assembly 32, that is to say, the third driving member 33 and the jaw assembly 32 are located on the same side of the mounting base 31. The side of the seat 31 facing the clamping assembly 24 . The end of the third driving member 33 close to the mounting seat 31 has a first output shaft 331 , and the first output shaft 331 is in transmission connection with the jaw assembly 32 to drive the jaw assembly 32 to rotate. One end of the third driving member 33 away from the mounting base 31 has a second output shaft 332 that rotates synchronously with the first output shaft 331 . The origin detection component 40 includes a sensor 41 and a sensor 42 , the sensor 41 is mounted on the mounting base 31 , and the sensor 42 is mounted on the second output shaft 332 . In the process of the induction piece 42 rotating with the second output shaft 332, the induction piece 42 can pass the sensor 41, and the sensor 41 is used to detect the induction piece 42 passing it, so that the clamping jaw assembly 32 rotates and opens the cover every time. Or before the cover closing operation, the second output shaft 332 can drive the induction piece 42 to rotate and reset to the induction 41 first, so as to accurately control the rotation angle (that is, the number of rotations) of the jaw assembly 32, and then successfully complete the opening and closing. Cover or close the cover. Optionally, the third driving member 33 may be a double-axis motor. The second output shaft 332 is coaxial with the first output shaft 331 .

In this way, since the third driving member 33 and the jaw assembly 32 are located on the same side of the mounting base 31 , and the second output shaft 332 is located at the end of the third driving member 33 away from the mounting base 31 , and the induction piece 42 of the origin detection assembly 40 Installed on the second output shaft 332 . That is to say, the third drive member 33 and the origin detection assembly 40 are provided in the space on the side of the installation seat 31 where the jaw assembly 32 is installed, so that the space on the other side of the installation seat 31 does not need to be occupied, so that the cover can be rotated to open The structure of the mechanism 30 is more compact, which saves the occupied space and satisfies the design requirements of miniaturization and integration. In particular, there is no need to occupy the space on the side of the mounting base 31 away from the jaw assembly 32 to arrange the third drive member 33 and the origin position detection assembly 40, which is conducive to reducing the size of the rotation cover opening mechanism 30 in the first direction X, so that To meet the dimensional design requirements in the first direction X.

Specifically in the embodiment, the sensor 41 is connected in communication with the third drive member 33, so that when the sensor 41 detects the sensor sheet 42 passing by, the sensor 41 can control the first output shaft 331 of the third drive member 33 to stop. Rotate to make the jaw assembly 32 stop rotating, so that the next operation of opening or closing the cover can be successfully completed. Preferably, the sensor 41 can be a photoelectric switch.

Specifically in the embodiment shown in Fig. 4 and Fig. 5, the induction piece 42 is installed at the end of the second output shaft 332, the inductor 41 is installed on the mounting base 31 through the bracket 43, and is positioned at the position where the induction piece 42 follows the second output shaft 332. On the motion track that shaft 332 rotates. In this way, when the sensor 41 detects the sensor 42, it indicates that the sensor 42 rotates with the second output shaft 332 to the sensor 41. At this time, the sensor 41 can control the first output shaft 331 and the third driving member 33. The second output shaft 332 stops rotating, so that the induction piece 42 stays at the induction 41 .

In some embodiments, the driving assembly further includes a transmission structure 34, and the transmission structure 34 includes a rotating shaft 341, the rotating shaft 341 is rotatably connected to the mounting base 31, and fixedly connected to the jaw assembly 32, so that the jaw assembly 32 It can follow the rotating shaft 341 to rotate relative to the mounting base 31 . The rotating shaft 341 is in transmission connection with the first output shaft 331 , so that the first output shaft 331 can drive the rotating shaft 341 to rotate. In this way, when the clamping jaw assembly 32 clamps the tube cap b and needs to open or close the cover, the first output shaft 331 of the third driving member 33 rotates, thereby driving the rotating shaft 341 to rotate, and then driving the clamping jaw assembly 32 to rotate , so as to open or close the cap b clamped by the jaw assembly 32 . It can be understood that the axis of the rotating shaft 341 is parallel to the first direction X.

Specifically in the embodiment, the transmission structure 34 also includes a connecting block 345 fixedly connected to the rotating shaft 341, and the connecting block 345 is matched with the jaw assembly 32, so that the rotating shaft 341, the connecting block 345 and the jaw assembly 32 rotate synchronously . Wherein, the rotating shaft 341 and the connecting block 345 are integrally formed. In this way, by integrally forming the rotating shaft 341 and the connecting block 345, the assembly process of the shaft and the connecting block 345 is reduced, and assembly errors caused by the assembly of the rotating shaft 341 and the connecting block 345 are avoided, resulting in shaking during rotation, which is conducive to ensuring that The coaxiality requirements of the rotating shaft 341 and the jaw assembly 32 . Optionally, the rotating shaft 341 and the connecting block 345 can be integrally formed by machining. For example, the connecting shaft is first formed by turning, and then the connecting block 345 is formed by milling. The connecting block 345 and the clamping jaw assembly 32 are fastened and fixed by screws.

Specifically in the embodiment, the transmission structure 34 further includes a driving wheel 342 , a driven wheel 343 and a transmission belt 344 . The driving wheel 342 is installed on the first output shaft 331 so that the driving wheel 342 and the first output shaft 331 rotate synchronously. The driven wheel 343 is installed on the rotating shaft 341 so that the driven wheel 343 and the rotating shaft 341 rotate synchronously. The transmission belt 344 is sleeved between the driving wheel 342 and the driven wheel 343, so that when the first output shaft 331 of the third driver 33 drives the driving wheel 342 to rotate, the driving wheel 342 drives the driven wheel 343 to rotate through the transmission belt 344, and the driven wheel 343 The rotating shaft 341 is driven to rotate, and the rotating shaft 341 drives the jaw assembly 32 to rotate. It can be understood that, compared with the way of connecting the first output shaft 331 and the rotating shaft 341 in the first direction X with a coupling, the use of the belt drive method greatly reduces the time required for the first output shaft 331 to rotate and open the cover mechanism 30 in the first direction. The size in the direction X is beneficial to ensure that the size requirement of the rotary cap opening mechanism 30 in the first direction X is met.

It should be noted that, in this embodiment, the rotary motion of the first output shaft 331 is transmitted to the rotary shaft 341 through belt transmission. Of course, in some other embodiments, other transmission structures 34 can also be used to implement, such as gear transmission, chain transmission, etc., which are not limited here.

Further, the side of the mounting base 31 facing away from the jaw assembly 32 and the third driving member 33 has a receiving groove (not shown), and the above-mentioned driving wheel 342, driven wheel 343 and transmission belt 344 are all accommodated in the receiving groove. In this way, by opening a receiving groove on the mounting base 31, and using the receiving groove to accommodate the driving wheel 342, the driven wheel 343 and the transmission belt 344, on the one hand, it can protect the transmission parts; on the other hand, it makes the structure more compact and saves the cost. space taken up. Optionally, both longitudinal ends of the storage tank pass through the mounting seat 31 to form an opening e, which is beneficial to increase the operating space when assembling various components in the storage tank, and facilitates the assembly operation.

In some embodiments, each rotating cover opening mechanism 30 further includes a conductive slip ring 35 , the inner sleeve of the conductive slip ring 35 is sleeved on the rotating shaft 341 and rotates synchronously with the rotating shaft 341 . The outer casing of the conductive slip ring 35 is connected with the mounting base 31 so as to be relatively fixed with the mounting base 31 . Wherein, the inner sleeve of the conductive slip ring 35 is electrically connected with the jaw assembly 32 , and the outer sleeve of the conductive slip ring 35 is used for electrical connection with a power supply and/or a control circuit through a connecting wire. In this way, when the inner sleeve of the conductive slip ring 35 rotates with the rotating shaft 341, the outer sleeve of the conductive slip ring 35 remains stationary relative to the mounting seat 31, and the inner sleeve and the outer sleeve of the conductive slip ring 35 can also be kept in the process of relative movement. Electrical connection, so that the jaw assembly 32 can also maintain electrical connection with the external power supply during the rotation of the rotating shaft 341, ensuring the transmission of electrical energy and/or control signals for the jaw assembly 32, and avoiding entanglement or twisting of the connecting wire.

In some embodiments, the jaw assembly 32 has a first jaw 321 and a second jaw 322 that can be controllably moved toward or away from each other. A clamping position d for clamping the cap b is formed between the first clamping jaw 321 and the second clamping jaw 322 . Wherein, at least one of the first jaw 321 and the second jaw 322 is provided with an anti-slip top block 323 on a side facing the other. The anti-skid top block 323 is used to stop in the first direction X with the cap b clamped at the clamping position d. It can be understood that the first direction X is parallel to the axis of rotation 341 of the jaw assembly 32 (ie, the axis of the rotation axis 341 ). In this way, when the jaw assembly 32 rotates to open or close the cover, the top of the tube cover b abuts against the anti-slip top block 323, thereby preventing the tube cover b from facing the first direction X under the action of the sample tube a. The jaw 321 and the second jaw 322 move to ensure that the cover can be opened or closed smoothly. Preferably, anti-slip top blocks 323 are installed on the sides facing each other of the first clamping jaw 321 and the second clamping jaw 322 , so that the stopper on the tube cover b is more stable and reliable.

As shown in FIGS. 6 and 7 , another embodiment of the present application provides a clamping assembly, including a clamping module 720 and a driving module 730 . The clamping module 720 includes a first clamping block unit 721 and a second clamping block unit 722 arranged on the floating seat 22 along the third direction Z, and a clamping position is formed between the first clamping block unit 721 and the second clamping block unit 722 d. The driving module 730 is arranged on the floating base 22, and the first clamping unit 721 and the second clamping unit 722 of the driving module 730 are both drivingly connected to drive the first clamping unit 721 and the second clamping unit 722 to approach or move away from each other . Wherein, the third direction Z is perpendicular to the first direction X and the second direction Y respectively. Although FIG. 6 and FIG. 7 only show an embodiment in which a clamping position d is formed between the first clamping block unit 721 and the second clamping block unit 722, it can be understood that the first clamping block unit 721 and the second clamping block unit 721 Two or more clamping positions d can also be formed between the clamping block units 722, so as to clamp two or more sample tubes a at the same time.

Since the driving module 730 can drive the first clamping block unit 721 and the second clamping block unit 722 to move toward each other and clamp the sample tube a at the same time, the rotating cover opening mechanism 30 can move the sample tube a from the first clamping block unit 721 and the second clamping block unit 721 The middle position between the clamping block units 722 is inserted into the clamping position d, that is, for sample tubes a of different diameters, the position of the sample tube a transferred by the rotating cover opening mechanism 30 remains unchanged, which avoids the occurrence of clamping when the sample tube a is clamped. Deviating due to over-positioning, or even falling from the rotating cover opening mechanism 30, reduces the difficulty of debugging and improves compatibility.

Specifically in the embodiment, the driving module 730 includes a fourth driving member 731 and a second screw rod 732 . The fourth driving member 731 is disposed on the floating seat 22 and is in transmission connection with the second screw rod 732 to drive the second screw rod 732 to rotate around its own axis. The axial direction of the second threaded rod 732 is parallel to the third direction Z, and the second threaded rod 732 has a first threaded section (not shown) and a second threaded section (not shown) arranged along its axial direction. The helical directions of the first thread segment and the second thread segment are opposite. The first clamping block unit 721 is threadedly connected with the first thread segment, and a lead screw pair is formed between the two. The second clamping block unit 722 is threadedly connected with the second thread segment, and a lead screw pair is formed between the two.

In this way, when the sample tube a needs to be clamped, the fourth driving member 731 drives the second screw rod 732 to rotate in a rotational direction, thereby respectively driving the first clamping block unit 721 and the second clamping block unit 722 through the screw pair transmission approach each other along the axial direction of the second screw rod 732 until the sample tube a is clamped. When it is necessary to loosen the sample tube a, the driving member drives the second screw rod 732 to rotate in reverse, so as to drive the first clamping unit 721 and the second clamping unit 722 along the direction of the second screw rod 732 through the secondary transmission of the screw respectively. Axially move away from each other to the initial position, that is, the clamping of the sample tube a is released. It should be noted that the rotation of the second threaded rod 732 is used to drive the first clamping unit 721 and the second clamping unit 722 to approach or move away from each other, so that the movement of the first clamping unit 721 and the second clamping unit 722 is stable. Reliable, good precision, and high synchronization, to ensure stable clamping or loosening of the sample tube. Optionally, the fourth driving member 731 may use a motor.

Further, there is a bearing seat 733 on the floating base 22, one end of the second screw rod 732 is rotatably connected to the bearing seat 733, and the other end of the second screw rod 732 is connected to the output shaft of the fourth driving member 731, so as to The rotation is driven by the fourth driving member 731 .

In one embodiment, the first clamping block unit 721 includes a driving block 7211 , a first clamping block 7212 and a second elastic member 7213 , and the second clamping block unit 722 includes a second clamping block 7221 . The driving block 7211 and the second clamping block 7221 are disposed on the floating seat 22 along the third direction Z. The first clamping block 7212 is connected to the side of the driving block 7211 facing the second clamping block 7221 through the second elastic member 7213 , and the above-mentioned clamping position d is formed between the first clamping block 7212 and the second clamping block 7221 . The second elastic member 7213 is used to provide a pre-tightening force that makes the first clamping block 7212 move closer to the second clamping block 7221 . Both the driving block 7211 and the second clamping block 7221 are in transmission connection with the driving module 730, so that the driving module 730 can drive the driving block 7211 and the second clamping block 7221 to approach or move away from each other. Specifically, the driving block 7211 is screwed to the first threaded segment of the second screw rod 732 , and the second clamping block 7221 is screwed to the second threaded segment of the second screw rod 732 .

In this way, when the sample tube a needs to be clamped, the driving module 730 drives the second clamping block 7221 and the driving block 7211 to approach each other, so that the first clamping block 7212 and the second clamping block 7221 approach each other until the sample tube a is clamped . At this time, the driving block 7211 and the first clamping block 7212 overcome the pre-tightening force provided by the second elastic member 7213 and compress the second elastic member 7213, so that the second elastic member 7213 plays a role of buffering. That is to say, due to the existence of the second elastic member 7213, the impact between the first clamping block 7212 and the second clamping block 7221 and the sample tube a can be buffered, avoiding damage to the sample tube a, and further reducing the debugging time. difficulty. Optionally, the second elastic member 7213 can be a spring.

Specifically, in the embodiment, the floating base 22 is installed with a fourth sliding rail 7101 (see FIG. 7 ) extending along the third direction Z, and the driving block 7211 and the second clamping block 7221 are both slidably connected to the fourth sliding rail 7101 . Further, the first clamping block 7212 is also slidably connected to the fourth slide rail 7101 . In this way, the fourth sliding rail 7101 is used to guide the movement of the driving block 7211 , the first clamping block 7212 and the second clamping block 7221 along the third direction Z, so that the clamping action is more stable and reliable.

In one embodiment, the clamping mechanism 20 further includes a limiting member 760, and the limiting member 760 includes a fixed end (not shown in the figure) and a stop end (not shown in the figure) opposite to each other. The fixed end is fixedly connected with the base 21 . The floating seat 22 can move to a stop position in a direction away from the base 21 under the action of the pre-tightening force provided by the first elastic member 23 . When the floating seat 22 moves to the stop position, the floating seat 22 abuts against the stop portion, that is, the stop portion stops the floating seat 22 . In this way, when the floating seat 22 is impacted, the floating seat 22 can overcome the first elastic member 23 and move towards the direction close to the base 21 , that is, the first elastic member 23 is used to buffer the impact. When the impact on the floating seat 22 disappears, the floating seat 22 returns to the stop position in a direction away from the base 21 under the action of the pre-tightening force provided by the first elastic member 23 .

More specifically, the floating seat 22 has a through hole, and the limiting member 760 includes a rod 761 and a head 762 fixedly connected to one end of the rod 761 . The rod portion 761 is passed through the through hole, and the end of the rod portion 761 away from the head portion 762 is used as a fixed end, and is screwed to the base 21 . The head 762 serves as a stopper and is located on a side of the floating seat 22 away from the base 21 . Wherein, the outer diameter of the head 762 is larger than the inner diameter of the through hole, so that the head 762 can abut against the side of the floating seat 22 away from the base 21 to stop the floating seat 22 . Optionally, the limiting member 760 may use a limiting screw.

Further, there may be multiple limiting members 760, and the plurality of limiting members 760 are arranged at intervals along the circumferential edge of the floating seat 22, so that the floating seat 22 is limited by a plurality of limiting members 760 at the same time, so that The floating seat 22 is more stable to prevent the floating seat 22 from skewing. The first elastic member 23 can be sleeved on the outside of the rod portion 761 of the limiting member 760 , and the rod portion 761 is used to guide the expansion and contraction of the first elastic member 23 . For example, the floating seat 22 is a rectangular plate, and the number of the limiting members 760 is four, and the four limiting members 760 are arranged at four corners of the floating seat 22 . Certainly, the floating seat 22 is not limited to using a rectangular plate, and in other embodiments, the floating seat 22 may also be a circular plate, a square plate or a special-shaped plate, etc., which is not limited here.

In one embodiment, the clamping mechanism 20 further includes a guide module 770 , and the guide module 770 includes a first mounting plate 771 and a second mounting plate 772 . The first mounting plate 771 is mounted on the floating seat 22 , and the second mounting plate 772 is mounted on the base 21 . One of the first mounting plate 771 and the second mounting plate 772 has a second guide rail 773 , and the other has a guide block 774 . The second guide rail 773 extends along the direction in which the floating seat 22 moves relative to the base 21, and the guide block 774 is slidably connected to the second guide rail 773, so that the floating seat 22 can move relative to the base by utilizing the sliding fit of the guide block 774 and the second guide rail 773. The movement of 21 is guided, so that the movement of floating seat 22 is more stable and reliable, which is conducive to improving the buffering effect.

Optionally, the guide module 770 includes two, and the two guide modules 770 are respectively arranged on both sides of the floating seat 22 along the second direction Y perpendicular to the third direction Z and the first direction X, and the two guide modules The 770 is misplaced in the third direction Z, which is beneficial to improve the guiding effect.

In the clamping assembly in the above-mentioned embodiment, since the driving module 730 can drive the first clamping block unit 721 and the second clamping block unit 722 to move toward each other at the same time to clamp the sample tube a, so that the rotating cover opening mechanism 30 can move the sample tube a from The middle position between the first clamping block unit 721 and the second clamping block unit 722 is inserted into the clamping position d, that is, for sample tubes a of different pipe diameters, the position of the sample tube a transferred by the rotating uncapping mechanism 30 is unchanged, avoiding This eliminates the phenomenon that the sample tube a is skewed due to over-positioning when the sample tube a is clamped, and even falls from the rotating cap opening mechanism 30, which reduces the difficulty of debugging and improves compatibility.

Moreover, the rotation of the second screw rod 732 is used to drive the first clamping block unit 721 and the second clamping block unit 722 to approach or move away from each other at the same time, and the movement of the first clamping block unit 721 and the second clamping block unit 722 is stable, reliable and accurate. Better, and high synchronization, to ensure stable clamping or loosening of the sample tube.

In addition, when the sample tube a needs to be clamped, the driving module 730 drives the second clamping block 7221 and the driving block 7211 to approach each other, so that the first clamping block 7212 and the second clamping block 7221 approach each other until the sample tube a is clamped (At this time, the second elastic member 7213 has a certain amount of compression). Due to the existence of the second elastic member 7213, the impact of the first clamping block 7212, the second clamping block 7221 and the sample tube a can be buffered, avoiding damage to the sample tube a, and further reducing the difficulty of debugging.

Based on the above opening and closing cover device 1, the present invention also provides a nucleic acid extraction instrument, which includes a sample tube transfer device, a pipetting device, a nucleic acid extraction device and the opening and closing cover device 1 as described in any of the above embodiments. The sample tube transfer device is used to transfer the sample tube a to the clamping position or remove the sample tube a from the clamping position. The pipetting device is used to transfer the sample liquid in the sample tube a at the clamping position to the nucleic acid extraction device. The nucleic acid extraction device is used to extract nucleic acid from the sample liquid.

It should be noted that when the base 21 moves along the second direction Y to the position for taking samples, the sample tube transfer device puts the sample tube a containing the sample into each clamping position, and/or, the sample tube transfer device takes off Sample tube a (sample liquid has been transferred) on each clamping position. When the base 21 moves to the cover opening position along the second direction Y, the gripper assembly 32 of each rotary cover opening mechanism 30 clamps the tube cover b on the corresponding sample tube a and rotates to open or close the cover. When the base 21 moves to the pipetting position along the second direction Y, the pipetting device respectively absorbs the sample liquid in the sample tube a of each clamping position (at this time, the sample tube a is in the uncapped state), and transfers the sucked sample The solution was transferred to the nucleic acid extraction device. The nucleic acid extraction device performs nucleic acid extraction on the transferred sample liquid.

The working process of the nucleic acid extractor of an embodiment is described below in conjunction with accompanying drawing:

Firstly, the base 21 moves along the second direction Y to the setting-out position, the sample tube transfer device puts the sample tube a containing the sample into each clamping position, and the first clamping block 241 and the second clamping block 242 clamp Tighten the sample tube a of each clamping position.

Then, the base 21 moves to the position of the switch cover along the second direction Y, and the lifting drive member 62 drives the lifting seat 61 to move close to the clamping assembly 24 along the first direction X (before this, the origin position detection assembly 40 can be used to make the induction piece 42 return to the sensor 41), so that each jaw assembly 32 is respectively close to the sample tube a corresponding to the clamping position, and clamps the tube cover b on the sample tube a corresponding to the clamping position. Each jaw assembly 32 is individually rotated to unscrew the cover.

Then, the lifting driving member 62 drives the lifting base 61 to move away from the clamping assembly 24 along the first direction X until the tube cover b and the sample tube a are completely separated.

Then, the base 21 moves to the pipetting position along the second direction Y, and the pipetting device absorbs the sample liquid in the sample tube a of each clamping position respectively, and transfers the sample liquid to the nucleic acid extraction device, so that the nucleic acid extraction device Nucleic acid extraction is performed on this sample solution.

Then, the base 21 moves along the second direction Y to the switch cover position again. The lifting driver 62 drives the lifting seat 61 to move close to the clamping assembly 24 along the first direction X (before this, the origin position detection assembly 40 can be used to make the induction piece 42 return to the sensor 41), until each jaw assembly 32 clamps The held tube cap b pushes the corresponding sample tube a to move along the first direction X (compresses each first elastic member 23 at this time), until each first elastic member 23 produces a certain amount of compression.

Then, each jaw assembly 32 rotates until the cover is closed (the compression amount of each first elastic member 23 gradually decreases during the cover closing process, and the floating seat 22 gradually floats close to the rotary cover opening mechanism 30 along the first direction X).

Then, each clamping jaw assembly 32 releases each tube cover b, and the lifting drive member 62 drives the lifting seat 61 to move away from the clamping assembly 24 along the first direction X until each clamping jaw assembly 32 is separated from the corresponding tube cover b.

Then, the base 21 moves again along the second direction Y to the sample taking and setting out position, and repeats the operation according to the above steps, so as to realize the continuous pipetting and extraction operation.

The technical features of the above-mentioned embodiments can be combined arbitrarily. To make the description concise, all possible combinations of the technical features in the above-mentioned embodiments are not described. However, as long as there is no contradiction in the combination of these technical features, should be considered as within the scope of this specification.

The above-mentioned embodiments only express several implementation modes of the present application, and its description is more specific and detailed, but it should not be interpreted as a limitation on the scope of the patent application. It should be noted that those skilled in the art can make several modifications and improvements without departing from the concept of the present application, and these all belong to the protection scope of the present application. Therefore, the scope of protection of the patent application should be based on the appended claims.

Claims (27)

1. A switch cover device is characterized in that it comprises:

   Mount;

   The clamping mechanism includes a base, a floating seat, a plurality of first elastic members and a clamping assembly, the base is arranged on the mounting frame, the floating seat is movably connected to the base, and each of the first The elastic members are all abutted between the floating seat and the base to provide a pre-tightening force that makes the floating seat move away from the base along the first direction; the clamping assembly is arranged on the on a floating seat with at least two clamping positions for clamping the sample tube; and

   At least two rotary cover opening mechanisms are arranged on the mounting frame, and arranged in one-to-one correspondence with the clamping positions along the first direction, each of the rotary cover opening mechanisms is used to clamp the corresponding Clamp the cap of the sample tube in place and rotate it.
2. The switch cover device according to claim 1, wherein the clamping mechanism further comprises a guide rod, and one of the floating base and the base has a guide rod passing through the opposite sides thereof along the first direction. a guide hole, the guide rod is slidably passed through the guide hole, and is fixedly connected with the other one of the floating seat and the base;

   Wherein, there is a first floating gap between the guide hole and the guide rod.
3. The switch cover device according to claim 2, wherein the guide rods comprise a plurality, and each of the first elastic members is sleeved on the corresponding guide rods.
4. The switch cover device according to claim 1, wherein the base has a first slide rail extending longitudinally along the first direction, and the floating seat has a first slide rail that is slidably engaged with the first slide rail. a slider;

   Wherein, there is a second floating gap between the first slide rail and the first slider.
5. The switch cover device according to claim 1, wherein the clamping assembly includes a first clamping block and a second clamping block arranged on the floating seat along the second direction, the first clamping The at least two clamping positions are formed between the clamping block and the second clamping block, and at least one of the first clamping block and the second clamping block can be controlled along the the second direction is approaching or moving away from the other;

   Wherein, the second direction is perpendicular to the first direction.
6. The switch cover device according to claim 5, wherein the clamping assembly further comprises a first driving member, a first gear, a first rack and a second rack;

   The first driving member is installed on the floating seat, the first gear is installed on the output shaft of the first driving member, the first rack is arranged on the first clamping block, and the The second rack is arranged on the second clamping block;

   Both the first rack and the second rack extend lengthwise along the second direction, the first gear is located between the first rack and the second rack, and is connected to the The first rack meshes with the second rack.
7. The switch cover device according to claim 1, wherein the clamping assembly includes a clamping module and a driving module, and the clamping module includes a first clamping block unit arranged on the floating seat along the third direction and a second clamping block unit, at least two clamping positions are formed between the first clamping block unit and the second clamping block unit; the driving module is arranged on the floating seat, and the first clamping block unit A clamping block unit and the second clamping block unit are both drivingly connected to drive the first clamping block unit and the second clamping block unit to approach or move away from each other; wherein, the third direction is the same as the first clamping block unit Direction is vertical.
8. The switch cover device according to claim 7, wherein the driving module includes a fourth driving member and a second screw rod, the fourth driving member is arranged on the floating seat, and is connected to the second driving member. screw drive connection to drive the second screw to rotate around its own axis;

   The axial direction of the second threaded rod is parallel to the third direction, and has a first threaded segment and a second threaded segment arranged along its axial direction, the threads of the first threaded segment and the second threaded segment The direction of rotation is opposite; the first clamping block unit is screwed to the first threaded segment, and the second clamping block unit is screwed to the second threaded segment.
9. The switch cover device according to claim 7, wherein the first clamping block unit includes a driving block, a first clamping block and a second elastic member, and the second clamping block unit includes a second clamping block;

   The driving block and the second clamping block are arranged on the floating seat along the third direction, and the first clamping block is connected to the side of the driving block facing the second clamping block through the second elastic member. On one side, the clamping position is formed between the first clamping block and the second clamping block;

   Both the driving block and the second clamping block are in transmission connection with the driving assembly, so that the driving assembly can drive the driving block and the second clamping block to approach or move away from each other.
10. The switch cover device according to claim 9, wherein a fourth sliding rail extending along the third direction is installed on the floating seat, and the driving block and the second clamping block are both slidably connected to the on the fourth rail.
11. The switch cover device according to claim 10, wherein the first clamping block is slidably connected to the fourth slide rail.
12. The clamping mechanism according to claim 7, characterized in that, the clamping mechanism further comprises a limiter, the limiter comprises a fixed end and a stop end opposite to each other, and the fixed end is fixed to the base connected, the floating seat can move to a stop position in a direction away from the base under the action of the pre-tightening force provided by the first elastic member; when the floating seat moves to the stop position, the The floating seat is against the stop end.
13. The switch cover device according to claim 12, wherein the floating seat has a through hole, the limiting member includes a rod and a head fixedly connected to one end of the rod, and the rod passes through In the through hole, the end of the rod portion away from the head is used as the fixed end, and is threadedly connected with the base, and the head is used as the stop end, and is located on the floating seat away from the fixed end. one side of the base;

    Wherein, the outer diameter of the head is larger than the inner diameter of the through hole.
14. The switch cover device according to claim 7, wherein the clamping mechanism further includes a guide module, and the guide module includes a first mounting plate and a second mounting plate;

    The first mounting plate is mounted on the floating seat, the second mounting plate is mounted on the base, and one of the first mounting plate and the second mounting plate has a second guide rail, The other one has a guide block; the second guide rail extends along the direction in which the floating base moves relative to the base, and the guide block is slidably connected to the second guide rail.
15. The cover switch device according to claim 1, wherein the base is configured to controllably move relative to the installation frame along a second direction perpendicular to the first direction;

    During the movement of the base along the second direction, there is a cover opening and closing position such that each clamping position is opposite to the corresponding rotating cover opening mechanism in the first direction.
16. The cover opening and closing device according to claim 15, wherein the base also has a sample taking position and a liquid pipetting position during the process of moving along the second direction;

    When the base is at the taking and setting out position or the liquid pipetting position, each of the clamping positions and the corresponding rotating cap opening mechanism are arranged in a misaligned manner in the second direction.
17. The switch cover device according to claim 15, wherein the clamping mechanism further comprises a second driving member, a second gear and a third rack;

    The second driving member is installed on one of the base and the mounting bracket, the second gear is installed on the output shaft of the second driving member, and the third rack is arranged on the The other one of the base and the installation frame extends lengthwise along the second direction, and the second gear meshes with the third rack.
18. The switch cover device according to claim 1, characterized in that, the switch cover device further includes a lifting mechanism, the lifting mechanism includes a lifting seat and a lifting driving member, and the lifting seat is movable along the first direction Connected to the mounting frame, the at least two rotating cover opening components are mounted on the lifting base; the lifting drive is mounted on the mounting frame, and is in transmission connection with the lifting base.
19. The opening and closing device according to claim 1, wherein the rotating cover opening mechanism comprises:

    mount;

    A clamping jaw assembly, rotatably connected to the mounting base, for clamping the tube cover;

    The driving assembly includes a third driving member installed on the mounting seat, the third driving member is located on the same side of the mounting seat as the jaw assembly, and one end of the third driving member is close to the mounting seat It has a first output shaft, and the first output shaft is in transmission connection with the jaw assembly; the end of the third driving member away from the mounting seat has a second output shaft that rotates synchronously with the first output shaft; and

    The origin position detection component includes an inductor and an induction sheet, the induction sheet is installed on the mounting seat, and the induction sheet is installed on the second output shaft; the induction sheet follows the second output shaft During the rotation, the sensing piece can pass by the sensor, and the sensor is used to detect the passing of the sensing piece.
20. The cover opening and closing device according to claim 19, wherein the sensor is connected to the third driving member in communication;

    The sensor can control the first output shaft of the third drive member to stop rotating when the sensor detects the sensor plate passing by.
21. The switch cover device according to claim 19, wherein the sensor is a photoelectric switch.
22. The switch cover device according to claim 19, characterized in that, the driving assembly further includes a transmission structure, the transmission structure includes a rotating shaft, and the rotating shaft is rotatably connected to the mounting base and is connected to the The jaw assembly is fixed;

    The rotating shaft is in transmission connection with the first output shaft, so that the first output shaft can drive the rotating shaft to rotate.
23. The switch cover device according to claim 22, wherein the transmission structure further includes a connection block fixedly connected to the rotating shaft, and the connection block is matched with the jaw assembly;

    The rotating shaft is integrally formed with the connecting block.
24. The switch cover device according to claim 22, wherein the transmission structure further comprises a driving wheel, a driven wheel and a transmission belt, the driving wheel is installed on the first output shaft, and the driven wheel is installed on the A rotating shaft, the transmission belt is sheathed between the driving wheel and the driven wheel.
25. The switch cover device according to claim 24, characterized in that, the side of the mounting seat away from the jaw assembly and the third driving member has a receiving groove, and the driving wheel, the driven wheel and the transmission belt are all housed in the in the storage tank.
26. The switch cover device according to claim 19, wherein the jaw assembly has a first jaw and a second jaw that can be controlled to approach or move away from each other, and the first jaw and the second jaw A clamping position for clamping the cap is formed between the two jaws;

    Wherein, at least one of the first jaw and the second jaw is equipped with an anti-skid top block facing the other side, and the anti-skid top block is used for being clamped at the clamping position. The tube cover is stopped in a first direction, and the first direction is parallel to the rotation axis of the jaw assembly.
27. A nucleic acid extractor, characterized in that it comprises a sample tube transfer device, a pipetting device, a nucleic acid extraction device, and the opening and closing device according to claims 1-26;

    The sample tube transfer device is used to put a sample tube into the clamping position or remove the sample tube at the clamping position, and the pipetting device is used to transfer the sample liquid in the sample tube at the clamping position To the nucleic acid extraction device, the nucleic acid extraction device is used to extract nucleic acid from the sample liquid.

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