CN117838621A - Nanoscale multifunctional plaster for skin care and preparation method thereof - Google Patents
Nanoscale multifunctional plaster for skin care and preparation method thereof Download PDFInfo
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- CN117838621A CN117838621A CN202410029760.9A CN202410029760A CN117838621A CN 117838621 A CN117838621 A CN 117838621A CN 202410029760 A CN202410029760 A CN 202410029760A CN 117838621 A CN117838621 A CN 117838621A
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- 239000011505 plaster Substances 0.000 title claims abstract description 39
- 238000002360 preparation method Methods 0.000 title abstract description 10
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 30
- 239000004480 active ingredient Substances 0.000 claims abstract description 20
- 239000002539 nanocarrier Substances 0.000 claims abstract description 18
- 239000002105 nanoparticle Substances 0.000 claims abstract description 17
- 239000000377 silicon dioxide Substances 0.000 claims abstract description 15
- 239000002245 particle Substances 0.000 claims abstract description 11
- 239000000463 material Substances 0.000 claims abstract description 10
- 235000012239 silicon dioxide Nutrition 0.000 claims abstract description 9
- 239000000243 solution Substances 0.000 claims description 29
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 18
- 239000011159 matrix material Substances 0.000 claims description 13
- 238000003756 stirring Methods 0.000 claims description 12
- 108010010803 Gelatin Proteins 0.000 claims description 11
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 11
- 229920000159 gelatin Polymers 0.000 claims description 11
- 239000008273 gelatin Substances 0.000 claims description 11
- 235000019322 gelatine Nutrition 0.000 claims description 11
- 235000011852 gelatine desserts Nutrition 0.000 claims description 11
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 11
- 238000009210 therapy by ultrasound Methods 0.000 claims description 11
- 239000008367 deionised water Substances 0.000 claims description 10
- 229910021641 deionized water Inorganic materials 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- 239000000203 mixture Substances 0.000 claims description 8
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 5
- 238000010438 heat treatment Methods 0.000 claims description 5
- 229920002674 hyaluronan Polymers 0.000 claims description 5
- 229960003160 hyaluronic acid Drugs 0.000 claims description 5
- 229940069521 aloe extract Drugs 0.000 claims description 4
- 229960005150 glycerol Drugs 0.000 claims description 3
- 239000008174 sterile solution Substances 0.000 claims description 3
- 238000000034 method Methods 0.000 claims 1
- 230000008439 repair process Effects 0.000 abstract description 5
- 239000012466 permeate Substances 0.000 abstract description 3
- 230000008591 skin barrier function Effects 0.000 abstract description 2
- 238000012360 testing method Methods 0.000 description 7
- 230000000694 effects Effects 0.000 description 6
- 239000000047 product Substances 0.000 description 6
- 239000000725 suspension Substances 0.000 description 6
- 238000010998 test method Methods 0.000 description 5
- 238000002474 experimental method Methods 0.000 description 4
- 238000011056 performance test Methods 0.000 description 4
- 238000000527 sonication Methods 0.000 description 4
- 230000003110 anti-inflammatory effect Effects 0.000 description 3
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 239000012876 carrier material Substances 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 239000008240 homogeneous mixture Substances 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 230000003020 moisturizing effect Effects 0.000 description 2
- 238000010979 pH adjustment Methods 0.000 description 2
- 238000004806 packaging method and process Methods 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000029663 wound healing Effects 0.000 description 2
- -1 DPPH free radical Chemical class 0.000 description 1
- 241000699660 Mus musculus Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- 206010072170 Skin wound Diseases 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 235000014104 aloe vera supplement Nutrition 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 229940117173 croton oil Drugs 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 235000015872 dietary supplement Nutrition 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 239000000686 essence Substances 0.000 description 1
- 230000007760 free radical scavenging Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000009707 neogenesis Effects 0.000 description 1
- 230000000474 nursing effect Effects 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 230000036619 pore blockages Effects 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000002000 scavenging effect Effects 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a nanoscale multifunctional plaster for skin care and a preparation method thereof, wherein the plaster comprises 0.1-5% of a nano carrier material, 5-20% of an active ingredient and the balance of an active ingredient. Compared with the prior art, the invention uses the silicon dioxide nano particles as the carrier, and has smaller particle size and larger specific surface area. The multifunctional nanometer plaster can be better contacted with the skin after being smeared, and can permeate into the skin layer through the skin barrier, thereby realizing accurate treatment and repair.
Description
Technical Field
The invention relates to a skin care plaster, in particular to a nanoscale multifunctional plaster for skin care and a preparation method thereof.
Background
Skin care is a very important care task in people's daily life. Currently, there are a variety of skin care products on the market, such as masks, lotions, and essences. However, conventional skin care products have some drawbacks in meeting the needs of people for skin moisturization, nutritional supplements and repairs. First, these products have limitations in terms of duration of action, often requiring frequent use to maintain their effectiveness. Secondly, the ingredients of the conventional products cannot sufficiently penetrate into the deep layers of the skin, and it is difficult to achieve a comprehensive care effect. In addition, the effect of the traditional product is disturbed by environmental factors and external stimulus, and the nursing effect is unstable.
Disclosure of Invention
The invention aims to provide a nanoscale multifunctional plaster for skin care and a preparation method thereof.
In order to achieve the above purpose, the invention is implemented according to the following technical scheme:
the invention relates to a nanoscale multifunctional plaster for skin care, which comprises 0.1-5% of nano carrier material, 5-20% of active ingredient and the balance of active ingredient.
Preferably, the nano-carrier material is silica nano-particles; the active ingredient is one of glycerol, aloe extract or hyaluronic acid; the carrier matrix is gelatin or polyvinyl alcohol.
The invention relates to a preparation method of a nanoscale multifunctional plaster for skin care, which comprises the following steps:
s1: adding a proper amount of silicon dioxide nano-particles into a sterile container, adding enough sterile solution into the container, and performing ultrasonic treatment by using an ultrasonic treatment instrument to uniformly disperse the silicon dioxide nano-particles into the solution;
s2: fully dissolving glycerol in the solution in the step S1, and carrying out ultrasonic treatment to uniformly dissolve the solution;
s3: adding deionized water into a container, adding polyvinyl alcohol or gelatin into the deionized water, and dissolving the polyvinyl alcohol or gelatin by heating and stirring;
s4: adding the solution in the step S2 into the solution in the step S3, stirring properly to obtain a mixture, centrifugally separating and purifying the mixture to remove large particles, and obtaining the nano-scale multifunctional plaster for skin care.
The beneficial effects of the invention are as follows:
compared with the prior art, the nano-scale multifunctional plaster for skin care and the preparation method thereof utilize the silicon dioxide nano-particles as carriers, and have smaller particle size and larger specific surface area. The multifunctional nanometer plaster can be better contacted with the skin after being smeared, and can permeate into the skin layer through the skin barrier, thereby realizing accurate treatment and repair.
Compared with the traditional plaster, the nano-scale multifunctional plaster has the following technical effects:
1. the particle size is small: the use of the nanoscale carrier material enables the particle size of the plaster to be smaller, is beneficial to better contact and permeation with skin, and improves the treatment effect.
2. High fitting degree: the nanoscale multifunctional plaster can be better attached to the curved surface of the skin, is not easy to fall off, and ensures the lasting release of active ingredients.
3. High permeability: the nanoscale carrier has a larger specific surface area, can better permeate the skin layer, and realizes deep treatment and repair.
4. Multifunction: the nano-scale multifunctional plaster can be added with different active components such as anti-inflammatory components, repairing components and moisturizing components according to the needs, so as to realize comprehensive skin care effects.
5. Comfort feeling: the nanoscale carrier material can provide a light and breathable texture, avoid the problems of greasy feel and pore blockage, and enable a user to feel more comfortable.
Through the technical scheme, the nanoscale multifunctional plaster can provide accurate, efficient and comfortable skin care effects, overcomes the defects of the traditional products, and has wide application prospects.
Detailed Description
The invention is further described below in the following description of specific embodiments, which are presented for purposes of illustration and description, but are not intended to be limiting.
The invention relates to a nanoscale multifunctional plaster for skin care, which comprises 0.1-5% of nano carrier material, 5-20% of active ingredient and the balance of active ingredient.
Preferably, the nano-carrier material is silica nano-particles; the active ingredient is one of glycerol, aloe extract or hyaluronic acid; the carrier matrix is gelatin or polyvinyl alcohol.
The invention relates to a preparation method of a nanoscale multifunctional plaster for skin care, which comprises the following steps:
s1: adding a proper amount of silicon dioxide nano-particles into a sterile container, adding enough sterile solution into the container, and performing ultrasonic treatment by using an ultrasonic treatment instrument to uniformly disperse the silicon dioxide nano-particles into the solution;
s2: fully dissolving glycerol in the solution in the step S1, and carrying out ultrasonic treatment to uniformly dissolve the solution;
s3: adding deionized water into a container, adding polyvinyl alcohol or gelatin into the deionized water, and dissolving the polyvinyl alcohol or gelatin by heating and stirring;
s4: adding the solution in the step S2 into the solution in the step S3, stirring properly to obtain a mixture, centrifugally separating and purifying the mixture to remove large particles, and obtaining the nano-scale multifunctional plaster for skin care.
Example 1 anti-inflammatory repair type nanoscale multifunctional plaster
The formula comprises the following components:
nanocarrier material (silica nanoparticles): 2%
-active ingredient (aloe extract): 88 percent of
-a carrier matrix (gelatin): 10 percent of
The preparation method comprises the following steps:
1. preparing a nano-carrier suspension:
2 grams of silica nanoparticles were added to a sterile container.
-adding sufficient sterile deionized water to prepare a suspension of nanocarriers.
Sonication using a sonication apparatus to ensure that the nanoparticles are uniformly dispersed in the solution.
2. Preparing an active ingredient solution:
-preparing 88 g of aloe vera extract solution, ensuring adequate dissolution in the appropriate solvent.
-performing a suitable stirring or ultrasound treatment to ensure homogeneity of the active ingredient solution.
3. Preparing a carrier matrix:
-preparing 10 grams of gelatin.
-adding sufficient sterile deionized water to the sterile container.
-adding a carrier matrix to the solution and dissolving or dispersing it by stirring or heating.
4. Preparing a nano-scale multifunctional plaster:
slowly adding the nanocarrier suspension and the active ingredient solution to the carrier matrix solution while appropriate stirring is performed until a homogeneous mixture is obtained.
The addition of pH adjustment or other additives may be performed as desired.
Purifying the final mixture by filtration or centrifugation, etc., to remove residues or large particles.
Experimental data:
nano-carrier particle size: 50nm of
Active ingredient concentration: 1%
Plaster pH value: 6.5
Plaster appearance: homogeneous transparent gel-like substance
Plaster stability: stored at 25 ℃ for 3 months without significant change.
1. Anti-inflammatory performance test:
-test method: skin irritation test
-experimental parameters: using the normal population as the test subjects, a common mouse stimulant (e.g., croton oil) was selected.
-results: the stimulus response degree such as skin redness and swelling, itching and the like was recorded, and the evaluation was objectively carried out for 8 minutes.
2. And (3) repairing performance test:
-test method: wound healing experiments
-experimental parameters: the mice are used as animal models to make standard skin wounds, and nanoscale multifunctional plaster is smeared for treatment.
-results: wound healing rates were recorded and the extent of wound shrinkage and neogenesis formation were compared in the treated and control groups. Objective evaluation was 7 points.
3. Moisture retention performance test:
-test method: skin moisture loss experiment
-experimental parameters: the skin of the normal population was used as the test subject, ensuring proper skin cleaning and dryness prior to testing.
-results: the skin moisture loss (TEWL) was measured using a skin moisture loss meter, and the skin moisture loss was 14%.
Example 2 antioxidant moisturizing nanoscale multifunctional plaster
The formula comprises the following components:
nanocarrier material (silica nanoparticles): 3%
-active ingredient (hyaluronic acid): 82%
-a carrier matrix (polyvinyl alcohol): 15%
The preparation method comprises the following steps:
1. preparing a nano-carrier suspension:
3 grams of silica nanoparticles were added to a sterile container.
-adding sufficient sterile deionized water to prepare a suspension of nanocarriers.
Sonication using a sonication apparatus to ensure that the nanoparticles are uniformly dispersed in the solution.
2. Preparing an active ingredient solution:
preparing 82 grams of hyaluronic acid solution, ensuring adequate dissolution in the appropriate solvent.
-performing a suitable stirring or ultrasound treatment to ensure homogeneity of the active ingredient solution.
3. Preparing a carrier matrix:
-preparing 15 g of polyvinyl alcohol.
-adding sufficient sterile deionized water to the sterile container.
-adding a carrier matrix to the solution and dissolving or dispersing it by stirring or heating.
4. Preparing a nano-scale multifunctional plaster:
slowly adding the nanocarrier suspension and the active ingredient solution to the carrier matrix solution while appropriate stirring is performed until a homogeneous mixture is obtained.
The addition of pH adjustment or other additives may be performed as desired.
Purifying the final mixture by filtration or centrifugation, etc., to remove residues or large particles.
5. Packaging and storing:
packaging the prepared nano-scale multifunctional plaster into a sterile container to ensure good sealing.
Storage in cool, dry places, avoiding direct sunlight.
Nano-carrier particle size: 70nm of
Active ingredient concentration: 2%
Plaster pH value: 6.8
Plaster appearance: homogeneous semitransparent gel-like substance
Plaster stability: stored at 30 ℃ for 3 months without obvious change
1. And (3) oxidation resistance test:
-test method: free radical scavenging Capacity experiment
-experimental parameters: hydrogen peroxide or DPPH free radical was used and the scavenging ability of the nanoscale multifunctional plasters was tested at different concentrations.
-results: the clearance of the nanoscale multifunctional plaster to free radicals was recorded and IC50 values (concentration inhibition of 70%) were calculated.
2. Moisture retention performance test:
-test method: skin moisture loss experiment
-experimental parameters: the skin of the normal population was used as the test subject, ensuring proper skin cleaning and dryness prior to testing.
-results: the skin moisture loss (TEWL) was measured using a skin moisture loss meter, and the skin moisture loss was 8%.
The technical scheme of the invention is not limited to the specific embodiment, and all technical modifications made according to the technical scheme of the invention fall within the protection scope of the invention.
Claims (3)
1. A nanoscale multifunctional plaster for skin care, characterized in that: comprises nano carrier material, active component and carrier matrix, wherein the nano carrier material accounts for 0.1-5% by weight, the carrier matrix accounts for 5-20% by weight, and the rest is active component.
2. The nanoscale multifunctional plaster for skin care according to claim 1, characterized in that: the nano-carrier material is silicon dioxide nano-particles; the active ingredient is one of glycerol, aloe extract or hyaluronic acid; the carrier matrix is gelatin or polyvinyl alcohol.
3. A method for preparing a nanoscale multifunctional plaster for skin care, which is characterized by comprising the following steps:
s1: adding a proper amount of silicon dioxide nano-particles into a sterile container, adding enough sterile solution into the container, and performing ultrasonic treatment by using an ultrasonic treatment instrument to uniformly disperse the silicon dioxide nano-particles into the solution;
s2: fully dissolving glycerol in the solution in the step S1, and carrying out ultrasonic treatment to uniformly dissolve the solution;
s3: adding deionized water into a container, adding polyvinyl alcohol or gelatin into the deionized water, and dissolving the polyvinyl alcohol or gelatin by heating and stirring;
s4: adding the solution in the step S2 into the solution in the step S3, stirring properly to obtain a mixture, centrifugally separating and purifying the mixture to remove large particles, and obtaining the nano-scale multifunctional plaster for skin care.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202410029760.9A CN117838621A (en) | 2024-01-09 | 2024-01-09 | Nanoscale multifunctional plaster for skin care and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202410029760.9A CN117838621A (en) | 2024-01-09 | 2024-01-09 | Nanoscale multifunctional plaster for skin care and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN117838621A true CN117838621A (en) | 2024-04-09 |
Family
ID=90545838
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202410029760.9A Pending CN117838621A (en) | 2024-01-09 | 2024-01-09 | Nanoscale multifunctional plaster for skin care and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN117838621A (en) |
-
2024
- 2024-01-09 CN CN202410029760.9A patent/CN117838621A/en active Pending
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