CN117838065A - Method, device, apparatus and storage medium for detecting self-fluorescence tissue - Google Patents
Method, device, apparatus and storage medium for detecting self-fluorescence tissue Download PDFInfo
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Abstract
The method comprises the steps of determining the interference frequency generated by a light emitting device in a current detection scene so as to determine the laser modulation frequency different from the interference frequency, avoiding overlapping of the laser modulation frequency and the interference frequency of the light emitting device, relieving the interference problem of the interference frequency of the light emitting device on the detection process of the self-fluorescence tissue, and ensuring the smooth detection process of the self-fluorescence tissue. After the modulated laser is emitted, receiving a target optical signal of the current position contacted by the probe; performing spectrum analysis on the target optical signal, determining a spectrum intensity value of a laser modulation frequency in the target optical signal, and determining the spectrum intensity value of the laser modulation frequency as a fluorescence intensity value of the current position; and judging whether the current part contacted by the probe belongs to the target part of the human body or not according to the fluorescence intensity value of the current part, and improving the detection accuracy of the self-fluorescence tissue.
Description
Technical Field
The present application relates to the field of medical detection technologies, and in particular, to a method, an apparatus, a device, and a storage medium for detecting an auto-fluorescent tissue.
Background
Scientific researches show that the partial tissue of the human body has fluorescence characteristics, and belongs to an autofluorescence tissue, namely the autofluorescence tissue can emit weak fluorescence under the excitation action of excitation light in a certain wavelength range. Wherein the autofluorescent tissue comprises parathyroid gland, and the parathyroid gland can generate weak fluorescence with peak value of 820-830 nm under the excitation of 785nm wavelength laser.
Generally, the detection scene of the self-fluorescence tissue is a surgery scene, and the surgery process is assisted by detecting the self-fluorescence tissue in the surgery scene, so that the smooth operation process is ensured. For example, the human body has two pairs of parathyroid glands, which are respectively positioned at the middle and lower parts of the back surfaces (or buried in the thyroid glands) of the left and right leaves, and have the main functions of secreting parathyroid hormone and regulating the metabolism of calcium and phosphorus in the body. Due to the above positional relationship between thyroid and parathyroid, parathyroid is easily resected by mistake in thyroidectomy for removing thyroid tumor, which brings great hidden trouble to the operation process. Since parathyroid glands are self-fluorescent tissue, detection of self-fluorescent tissue such as parathyroid glands is required during the procedure described above to avoid miscut of parathyroid glands. Therefore, the detection accuracy of the self-fluorescence tissue plays a vital role in the safe and smooth operation process.
According to the research, the existence of a shadowless lamp and the like in the operation scene causes that the detection equipment of the self-fluorescence tissue can not accurately identify the fluorescence intensity of the self-fluorescence tissue under the interference of the shadowless lamp, and then the self-fluorescence tissue can not be detected; and because the self-fluorescence tissue is smaller, the self-fluorescence tissue is difficult to be directly observed by human eyes in a detection scene, and is easy to be miscut in the operation process, so that the postoperative life of a patient is endangered. It is therefore particularly important to provide a method for detecting autofluorescent tissue that alleviates the above problems and is more accurate.
Disclosure of Invention
The embodiment of the application at least provides a detection method, equipment, a device and a storage medium of an autofluorescence tissue.
In a first aspect, an embodiment of the present application provides a method for detecting an auto-fluorescent tissue, including:
acquiring a luminous signal of a luminous device of a current detection scene;
performing spectrum analysis on the luminous signals to determine the interference frequency generated by the luminous device in the current detection scene;
determining a laser modulation frequency based on the interference frequency generated by the light emitting device; wherein the laser modulation frequency is a different frequency than the interference frequency;
Modulating laser based on the laser modulation frequency, generating and transmitting modulated laser, and then receiving a target optical signal of the current part contacted by a probe of the detection equipment of the self-fluorescence tissue;
performing spectrum analysis on the target optical signal, determining a spectrum intensity value of the laser modulation frequency in the target optical signal, and determining the spectrum intensity value of the laser modulation frequency as a fluorescence intensity value of the current position;
judging whether the current part contacted by the probe belongs to a target part of a human body or not according to the fluorescence intensity value of the current part, wherein the target part belongs to an autofluorescence tissue.
In an alternative embodiment, the determining the laser modulation frequency based on the interference frequency generated by the light emitting device includes:
determining a frequency range according to the interference frequency generated by the light emitting device and a set frequency threshold, wherein the frequency range comprises: a first frequency range that is greater than a first frequency value, which is a frequency sum value between the interference frequency and the frequency threshold, and/or a second frequency range that is less than a second frequency value, which is a frequency difference value between the interference frequency and the frequency threshold;
And selecting the laser modulation frequency from the frequency range.
Here, by selecting the laser modulation frequency from the determined frequency range, the deviation between the laser modulation frequency and the interference frequency is larger, and the problem of inaccurate fluorescence intensity extraction caused by the fact that the laser modulation frequency is too close to the interference frequency is avoided.
In an optional implementation manner, the determining, according to the fluorescence intensity value of the current location, whether the current location contacted by the probe belongs to a target location of a human body includes:
determining a fluorescence intensity background value corresponding to the current detection scene; the fluorescence intensity background value is used for representing reference fluorescence intensity values of other parts except the target part in the current detection scene;
and when the fluorescence intensity value of the current part is larger than the fluorescence intensity background value of the target multiple, determining that the current part contacted by the probe belongs to the target part of the human body.
In an optional implementation manner, the determining the fluorescent intensity background value corresponding to the current detection scene includes:
acquiring an optical signal of at least one preset part under the irradiation of the modulated laser;
performing spectrum analysis on the optical signal of the preset part to determine the fluorescence intensity value of the preset part;
And determining a fluorescence intensity background value corresponding to the current detection scene according to the fluorescence intensity value of the at least one preset part.
The fluorescent intensity background value corresponding to the current detection scene can be accurately determined through the fluorescent intensity value of at least one preset part, so that whether the current part is a target part can be accurately judged by using the fluorescent intensity background value, and the detection precision is improved.
In an alternative embodiment, the target multiple is determined according to the following steps:
in response to a target operation triggered by a detection device for the autofluorescent tissue, a target value input at the detection device for the autofluorescent tissue is received and the target value is determined as the target multiple.
Here, the value of the target multiple can be flexibly set by a user, so as to meet the requirements of different detection precision and improve the flexibility of the detection process.
In an alternative embodiment, the method further comprises: and when the current part contacted by the probe is determined to belong to the target part, controlling the detection equipment of the self-fluorescence tissue to send out a prompt tone.
In an alternative embodiment, the method further comprises:
and determining passband parameters of a bandpass filter according to the laser modulation frequency and the frequency deviation value, wherein the passband parameters comprise: the band-pass filter allows a frequency range to pass, the maximum frequency of the frequency range is the frequency sum of the laser modulation frequency and the frequency deviation value, and the minimum frequency of the frequency range is the frequency difference between the laser modulation frequency and the frequency deviation value;
Filtering the target optical signal by using the band-pass filter under the passband parameters to obtain a processed signal;
the performing spectrum analysis on the target optical signal includes: and carrying out spectrum analysis on the processed signal.
Here, by performing filtering processing on the target optical signal, a processed signal is obtained, and compared with performing spectrum analysis on the target optical signal before filtering, the processed signal is subjected to spectrum analysis, the workload of the analysis process is less, and the spectrum of the processed signal is simpler, so that the spectrum intensity value at the laser modulation frequency can be obtained more easily based on the spectrum of the processed signal.
In an alternative embodiment, the target site comprises parathyroid glands and the light emitting device comprises a shadowless lamp.
In a second aspect, embodiments of the present application further provide a detection apparatus for an autofluorescent tissue, including: the device comprises a controller, a laser emitter and a probe; the laser transmitter is used for transmitting modulated laser under the control of the controller; the probe is used for collecting a target optical signal of a current part in contact and sending the target optical signal to the controller, and the target optical signal comprises a fluorescent signal generated by the current part under the irradiation of the modulated laser; the controller is configured to perform the method for detecting an autofluorescent tissue according to the first aspect or any of the embodiments.
In a third aspect, an optional implementation manner of the present application further provides a detection device for an auto-fluorescent tissue, including:
the acquisition module is used for acquiring a luminous signal of the luminous device of the current detection scene;
the first determining module is used for carrying out spectrum analysis on the luminous signals and determining the interference frequency generated by the luminous device in the current detection scene; and determining a laser modulation frequency based on the interference frequency generated by the light emitting device; wherein the laser modulation frequency is a different frequency than the interference frequency;
the receiving module is used for modulating the laser based on the laser modulation frequency, generating and transmitting modulated laser and then receiving a target optical signal of the current position contacted by the probe of the detection equipment of the self-fluorescence tissue;
the second determining module is used for carrying out spectrum analysis on the target optical signal, determining a spectrum intensity value of the laser modulation frequency in the target optical signal, and determining the spectrum intensity value of the laser modulation frequency as a fluorescence intensity value of the current position;
and the judging module is used for judging whether the current part contacted by the probe belongs to a target part of a human body or not according to the fluorescence intensity value of the current part, and the target part belongs to an autofluorescence tissue.
In a fourth aspect, the present application provides a computer-readable storage medium having stored thereon a computer program which, when executed by a processor, performs the steps of the method for detection of auto-fluorescent tissue according to the first aspect or any of the embodiments described above.
It is to be understood that both the foregoing general description and the following detailed description are exemplary and explanatory only and are not restrictive of the aspects of the present application.
According to the detection method, the detection equipment, the detection device and the storage medium for the self-fluorescence tissue, before the detection of the self-fluorescence tissue, the light-emitting signals of the light-emitting devices in the current detection scene are subjected to spectrum analysis, so that the interference frequency generated by the light-emitting devices in the current detection scene is determined, and then the laser modulation frequency different from the interference frequency is determined, so that the overlapping of the laser modulation frequency and the interference frequency of the light-emitting devices is avoided, the interference problem of the interference frequency of the light-emitting devices on the detection process of the self-fluorescence tissue is relieved, and the smooth detection process of the self-fluorescence tissue is ensured.
Further, after determining the laser modulation frequency, modulating the laser based on the laser modulation frequency, generating and transmitting the modulated laser, and receiving a target optical signal of the current position contacted by the probe. The spectrum analysis is carried out on the target optical signal, so that the spectrum intensity value of the laser modulation frequency in the target optical signal is determined, and the fluorescence signal of the self-fluorescence tissue is excited by the modulated laser, so that the spectrum intensity value of the laser modulation frequency is determined as the fluorescence intensity value of the current position, the accuracy of the fluorescence intensity value of the current position can be ensured, further, according to the fluorescence intensity value of the current position, whether the current position contacted by the probe belongs to the target position can be accurately judged, and the detection accuracy of the self-fluorescence tissue is improved.
In order to make the above objects, features and advantages of the present application more comprehensible, preferred embodiments accompanied with figures are described in detail below.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings that are necessary for use in the embodiments are briefly described below, which drawings are incorporated in and form a part of the present description, these drawings illustrate embodiments consistent with the present application and together with the description serve to explain the technical solutions of the present application. It is to be understood that the following drawings illustrate only certain embodiments of the present application and are therefore not to be considered limiting of its scope, for the person of ordinary skill in the art may derive other relevant drawings from the drawings without inventive effort.
FIG. 1 is a flow chart of a method for detecting autofluorescent tissue according to some embodiments of the present application;
FIG. 2 illustrates a workflow diagram of an apparatus for detection of autofluorescent tissue provided in some embodiments of the present application;
FIG. 3 is a schematic diagram illustrating a detection process of autofluorescent tissue provided by some embodiments of the present application;
FIG. 4 is a schematic diagram of an apparatus for detecting self-fluorescent tissue according to some embodiments of the present application;
fig. 5 is a schematic structural view of an apparatus for detecting an auto-fluorescent tissue according to some embodiments of the present application.
Detailed Description
For the purposes of making the objects, technical solutions and advantages of the embodiments of the present application more clear, the technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application, and it is apparent that the described embodiments are only some embodiments of the present application, but not all embodiments. The components of the embodiments of the present application, as generally described and illustrated herein, may be arranged and designed in a wide variety of different configurations. Thus, the following detailed description of the embodiments of the present application is not intended to limit the scope of the application, as claimed, but is merely representative of selected embodiments of the application. All other embodiments, which can be made by those skilled in the art based on the embodiments of the present application without making any inventive effort, are intended to be within the scope of the present application.
Today, in surgical scenes, it is possible to use a detection device for autofluorescent tissue, which detects the autofluorescent tissue. The detection equipment of the self-fluorescence tissue is used for collecting the fluorescence intensity of the part after the laser is emitted, and judging whether the part is the self-fluorescence tissue or not according to the fluorescence intensity of the part, wherein the fluorescence intensity of the part can be a signal value at the laser frequency.
It has been found that there are generally shadowless lamps in a surgical scene, which may be dc-driven or ac-driven. When the shadowless lamp is output by alternating current driving, the shadowless lamp has a modulation process, and then an alternating current frequency exists. Because the alternating current driven shadowless lamp has alternating current frequency, the alternating current driven shadowless lamp can interfere with the detection process of the detection equipment of the self-fluorescent tissue. For example, if the laser frequency of the laser emitted by the self-fluorescent tissue detection device overlaps with the ac frequency of the shadowless lamp, the frequency of the fluorescent signal of the self-fluorescent tissue is submerged by the ac frequency of the shadowless lamp, so that the self-fluorescent tissue detection device cannot accurately identify the fluorescent intensity of the self-fluorescent tissue, and thus cannot detect the self-fluorescent tissue.
In order to solve the above problems, the present application provides a method for detecting an autofluorescence tissue, before detecting the autofluorescence tissue, by performing spectrum analysis on a light emitting signal of a light emitting device in a current detection scene, determining an interference frequency generated by the light emitting device in the current detection scene, and further determining a laser modulation frequency different from the interference frequency, so as to avoid overlapping of the laser modulation frequency and the interference frequency of the light emitting device, alleviate the interference problem of the interference frequency of the light emitting device on the detection process of the autofluorescence tissue, and ensure that the detection process of the autofluorescence tissue is performed smoothly.
Further, after determining the laser modulation frequency, modulating the laser based on the laser modulation frequency, generating and transmitting the modulated laser, and receiving a target optical signal of the current position contacted by the probe. The spectrum analysis is carried out on the target optical signal, so that the spectrum intensity value of the laser modulation frequency in the target optical signal is determined, and the fluorescence signal of the self-fluorescence tissue is excited by the modulated laser, so that the spectrum intensity value of the laser modulation frequency is determined as the fluorescence intensity value of the current position, the accuracy of the fluorescence intensity value of the current position can be ensured, further, according to the fluorescence intensity value of the current position, whether the current position contacted by the probe belongs to the target position can be accurately judged, and the detection accuracy of the self-fluorescence tissue is improved.
The present invention is directed to a method for manufacturing a semiconductor device, and a semiconductor device manufactured by the method.
It should be noted that: like reference numerals and letters denote like items in the following figures, and thus once an item is defined in one figure, no further definition or explanation thereof is necessary in the following figures.
For the sake of understanding the present embodiment, a method for detecting an auto-fluorescent tissue according to the present embodiment will be described in detail. The execution main body of the detection method of the self-fluorescence tissue provided by the embodiment of the application is generally a computer device with a certain computing capability, and the computer device comprises a terminal device or a server, for example, and the terminal device can be the detection device of the self-fluorescence tissue and the like. In some possible implementations, the method of detecting autofluorescence tissue may be implemented by way of a processor invoking computer readable instructions stored in a memory.
Referring to fig. 1, a flow chart of a method for detecting an auto-fluorescent tissue according to an embodiment of the present application is shown, where the method includes S101-S106, where:
s101, acquiring a light-emitting signal of a light-emitting device of a current detection scene.
Because the light emitting devices existing in different detection scenes are different, the interference frequencies generated by the different light emitting devices may be different, so that in order to accurately identify the self-fluorescent tissue, the light emitting signals of the light emitting devices of the current detection scene can be acquired before the detection of the self-fluorescent tissue in the current detection scene, so as to determine the interference frequencies existing in the current detection scene. For example, a probe of a detection apparatus of an autofluorescent tissue may be used to acquire a light emission signal of a light emitting device of a current detection scene, or a signal receiving apparatus may be used to acquire a light emission signal of a light emitting device of a current detection scene, so that a subject may perform spectral analysis on the acquired light emission signal. Wherein the light emitting means may comprise means having an interference frequency, such as shadowless lamps.
S102, performing spectrum analysis on the luminous signals to determine the interference frequency generated by the luminous device in the current detection scene.
The method can convert the luminous signal into an electric signal, convert the electric signal into a digital signal from an analog signal to obtain a converted luminous signal, and further convert the converted luminous signal into a frequency domain by utilizing a Fourier transform method to obtain a frequency spectrum of the luminous signal, wherein the frequency spectrum of the luminous signal comprises a plurality of frequency spectrum components with different frequencies. According to the frequency spectrum, the interference frequency generated by the light emitting device in the current detection scene can be determined, for example, the interference frequency can be determined according to the frequency of the peak value of the frequency spectrum components in the frequency spectrum; alternatively, the interference frequency may be determined based on the frequency difference between the peaks of two adjacent spectral components.
After the spectrum of the luminescence signal is determined, the display screen of the detection device of the self-fluorescence tissue can be controlled to display the spectrum of the luminescence signal, so that the staff can determine the interference frequency according to the displayed spectrum, or after the interference frequency is determined, the staff can also verify whether the obtained interference frequency is accurate or not according to the displayed spectrum, and the like.
S103, determining a laser modulation frequency based on the interference frequency generated by the light emitting device; wherein the laser modulation frequency is a different frequency than the interference frequency.
After determining the interference frequency generated by the light emitting device, the laser modulation frequency may also be determined according to the interference frequency, for example, a frequency different from the interference frequency may be randomly selected as the laser modulation frequency.
In order to ensure the detection precision of the subsequent self-fluorescence tissue, the deviation between the laser modulation frequency and the interference frequency can be enabled to meet the requirements. Accordingly, determining the laser modulation frequency based on the interference frequency generated by the light emitting device may include: determining a frequency range according to the interference frequency generated by the light emitting device and a set frequency threshold, wherein the frequency range comprises: a first frequency range that is greater than a first frequency value, which is a frequency sum value between the interference frequency and the frequency threshold, and/or a second frequency range that is less than a second frequency value, which is a frequency difference value between the interference frequency and the frequency threshold; and selecting the laser modulation frequency from the frequency range.
For example if the interference frequency isf a The frequency threshold isf b Then determine the first frequency valuef 1 =f a +f b Second frequency valuef 2 =f a -f b The frequency range includes: greater than a first frequency valuef 1 And/or less than a second frequency valuef 2 Is provided for the second frequency range of (a). And then randomly selecting a frequency from the frequency range as the laser modulation frequency. Wherein the frequency threshold may be set as desired, and is not particularly limited herein.
By selecting the laser modulation frequency from the determined frequency range, the deviation between the laser modulation frequency and the interference frequency is larger, and the problem of inaccurate fluorescence intensity extraction caused by the fact that the laser modulation frequency is too close to the interference frequency is avoided.
And S104, modulating the laser based on the laser modulation frequency, and receiving a target optical signal of the current position contacted by the probe of the detection device of the self-fluorescence tissue after generating and transmitting the modulated laser.
When the method is implemented, after the laser modulation frequency is determined, the laser modulation frequency can be sent to the detection equipment of the self-fluorescence tissue, so that the detection equipment of the self-fluorescence tissue can modulate laser according to the laser modulation frequency to generate modulated laser, and the frequency of the modulated laser can be matched with the laser modulation frequency. And causing the laser emitter of the detection device of the self-fluorescent tissue to emit modulated laser light so that the self-fluorescent tissue can generate a fluorescent signal under excitation of the modulated laser light.
In the current detection scene, medical staff can hold a laser emitter by one hand and a probe by the other hand, the laser emitter is used for emitting modulated laser, and the probe is used for collecting a target optical signal of the current contacted part, so that the medical staff can search a target part through the movement of the probe, wherein the target part belongs to an autologous fluorescent tissue, and for example, the target part can comprise parathyroid glands. In the process of moving the probe, receiving the target optical signal of the current part contacted by the probe in real time so as to judge whether the contacted current part belongs to the target part according to the target optical signal, thereby realizing the detection of the target part.
Considering that the spectral intensity value at the laser modulation frequency is required later, the frequency of the target optical signal can be filtered before spectral analysis, and other frequencies with larger deviation from the laser modulation frequency can be screened out.
In the implementation, after receiving the target optical signal of the current position contacted by the probe, the method may further include: and determining passband parameters of a bandpass filter according to the laser modulation frequency and the frequency deviation value, wherein the passband parameters comprise: the band-pass filter allows a frequency range to pass, the maximum frequency of the frequency range is the frequency sum of the laser modulation frequency and the frequency deviation value, and the minimum frequency of the frequency range is the frequency difference between the laser modulation frequency and the frequency deviation value; and filtering the target optical signal by using the band-pass filter under the passband parameters to obtain a processed signal so that the processed signal can be subjected to spectrum analysis later to determine the fluorescence intensity value of the current position.
The frequency deviation value can be set according to the requirement. By way of example, assuming a laser modulation frequency of 900 hz and a frequency deviation value of 200 hz, the passband parameters may be [700, 1100], i.e., the bandpass filter allows frequencies between 700 hz and 1100 hz to pass (including 700 hz and 1100 hz). And filtering the target optical signal by using a band-pass filter under the passband parameters, namely filtering other frequencies outside the frequency range indicated by the passband parameters to obtain a processed signal.
The target optical signal is filtered to obtain a processed signal, compared with the spectrum analysis of the target optical signal before filtering, the spectrum analysis of the processed signal is performed, the workload of the analysis process is less, and the spectrum of the processed signal is simpler, so that the spectrum intensity value at the laser modulation frequency can be obtained easily based on the spectrum of the processed signal.
S105, performing spectrum analysis on the target optical signal, determining a spectrum intensity value of the laser modulation frequency in the target optical signal, and determining the spectrum intensity value of the laser modulation frequency as a fluorescence intensity value of the current position.
The method can convert the target optical signal into a target electrical signal, convert the target electrical signal into a digital signal from an analog signal, obtain a converted target optical signal, and further convert the converted target optical signal into a frequency domain by a Fourier transform method to obtain a frequency spectrum of the target optical signal. According to the spectrum of the target optical signal, determining a spectrum intensity value at the laser modulation frequency, and determining the spectrum intensity value of the laser modulation frequency as the fluorescence intensity value of the current position.
After the frequency spectrum of the target light signal is determined, the display screen of the detection device of the self-fluorescence tissue can be controlled to display the frequency spectrum of the target light signal, so that a worker can determine the fluorescence intensity value of the current position according to the displayed frequency spectrum of the target light signal, judge whether the current position belongs to the target position, and prompt the worker to find the target position if the current position is determined to belong to the target position.
S106, judging whether the current part contacted by the probe belongs to a target part of a human body or not according to the fluorescence intensity value of the current part, wherein the target part belongs to an autofluorescence tissue.
If the fluorescence intensity value of the current position is larger than the preset intensity threshold value, the brightness of the fluorescence signal sent by the current position is larger, and the current position contacted by the probe can be determined to belong to the target position; otherwise, if the fluorescence intensity value of the current part is smaller than or equal to the preset intensity threshold value, the brightness of the fluorescence signal sent out by the current part is smaller, and it can be determined that the current part contacted by the probe does not belong to the target part.
Considering that under the irradiation of laser, the fluorescence intensity of the self-fluorescence tissue and the non-self-fluorescence tissue is different, the fluorescence intensity of the non-self-fluorescence tissue can be taken as a reference, and whether the current position is the self-fluorescence tissue (namely whether the current position belongs to the target position) can be judged according to the currently detected fluorescence intensity value, so that the detection of the self-fluorescence tissue can be realized.
In the specific implementation, in step S106, determining whether the current portion contacted by the probe belongs to the target portion of the human body according to the fluorescence intensity value of the current portion may include: determining a fluorescence intensity background value corresponding to the current detection scene; the fluorescence intensity background value is used for representing reference fluorescence intensity values of other parts except the target part in the current detection scene; and when the fluorescence intensity value of the current part is larger than the fluorescence intensity background value of the target multiple, determining that the current part contacted by the probe belongs to the target part of the human body.
For example, the fluorescence intensity value of the other parts except the target part in the current detection scene can be used as the reference fluorescence intensity value. Alternatively, an average value of fluorescence intensity values of a plurality of other sites than the target site may be determined, and the average value may be used as the reference fluorescence intensity value.
Determining a fluorescence intensity background value corresponding to the current detection scene comprises the following steps: acquiring an optical signal of at least one preset part under the irradiation of the modulated laser; performing spectrum analysis on the optical signal of the preset part to determine the fluorescence intensity value of the preset part; and determining a fluorescence intensity background value corresponding to the current detection scene according to the fluorescence intensity value of the at least one preset part.
The predetermined location may be other tissue surrounding the target location that has an impact on detection of the target location. For example, if the target site is parathyroid, the predetermined site includes, but is not limited to: thyroid, lymph, fat, muscle, etc.
In implementation, for each preset position, the modulated laser can be used for irradiating the preset position, and the probe is used for contacting the preset position to collect the optical signal of the preset position. And performing spectrum analysis on the optical signal of the preset part to obtain a frequency spectrum corresponding to the optical signal, determining a frequency spectrum intensity value at the laser modulation frequency from the frequency spectrum corresponding to the optical signal, and determining the frequency spectrum intensity value at the laser modulation frequency as a fluorescence intensity value of the preset part. And the fluorescence intensity value of the preset part can be used as the fluorescence intensity background value corresponding to the current detection scene. For example, the preset position can be thyroid, namely, the fluorescence intensity value of thyroid is used as the fluorescence intensity background value.
When the number of the preset positions is multiple, after the fluorescent intensity values corresponding to the preset positions are determined, the median can be selected from the fluorescent intensity values of the preset positions and used as the fluorescent intensity background value. Alternatively, the fluorescence intensity values of a plurality of preset portions may be averaged, and the average value may be used as the fluorescence intensity background value. Or screening out the maximum value and the minimum value of the fluorescence intensity values of the preset parts, determining the average value of the screened fluorescence intensity values, and taking the average value as a fluorescence intensity background value.
According to the method and the device, the fluorescent intensity background value corresponding to the current detection scene can be accurately determined through the fluorescent intensity value of at least one preset part, so that whether the current part is the target part can be accurately judged by using the fluorescent intensity background value, and the detection precision is improved.
After the fluorescent intensity background value is determined, the target multiple is determined, and the fluorescent intensity background value of the target multiple is determined. And if the fluorescence intensity value of the current part is larger than the fluorescence intensity background value of the target multiple, determining that the current part contacted by the probe belongs to the target part. Otherwise, if the fluorescence intensity value of the current part is smaller than or equal to the fluorescence intensity background value of the target multiple, determining that the current part contacted by the probe does not belong to the target part.
The target multiple may be set as desired, for example, may be set to 2, 3, or the like. The target multiple can be a preset fixed value, and can be flexibly set according to the requirements of medical staff.
The target multiple may be determined, for example, according to the following steps: in response to a target operation triggered by a detection device for the autofluorescent tissue, a target value input at the detection device for the autofluorescent tissue is received and the target value is determined as the target multiple.
By way of example, the display screen of the detection device for the self-fluorescence tissue may be controlled to display a setting interface including an input box by triggering a target key of the detection device for the self-fluorescence tissue, so that a user may input any value in the input box, or may set a value range, the user may input any value in the value range in the input box, the value input by the user is the target value, and the target value is determined as the target multiple.
Alternatively, the auto-fluorescent tissue detection device may be provided with a rotary button, a numeric key, or the like, and the user rotates the rotary button of the auto-fluorescent tissue detection device to input a target value, which is a numerical value indicated by the rotary button, to the auto-fluorescent tissue detection device. Alternatively, the user may input a target value or the like on the detection device of the self-fluorescent tissue by triggering the operation of the numeric key.
In implementation, after the target multiple is determined, the target multiple can be displayed on a display interface of the detection device of the self-fluorescence tissue, so that the medical staff has clear knowledge of the set target multiple.
The value of the target multiple can be flexibly set by a user so as to meet the requirements of different detection precision and improve the flexibility of the detection process.
In an alternative embodiment, the method further comprises: and when the current part contacted by the probe is determined to belong to the target part, controlling the detection equipment of the self-fluorescence tissue to send out a prompt tone.
In consideration of the fact that the attention of medical staff is focused on a patient in the detection process, the detection equipment of the self-fluorescence tissue cannot be checked in real time, so that when the current position contacted by the probe is determined to belong to the target position, the detection equipment of the self-fluorescence tissue can be controlled to send out a prompt tone so as to prompt the medical staff to detect the target position.
Referring to the workflow diagram of the apparatus for detecting an autofluorescent tissue shown in fig. 2, taking an example of the apparatus for detecting an autofluorescent tissue with a target site being parathyroid gland and an execution subject being the autofluorescent tissue, a detection method will be exemplarily described with reference to fig. 2: after the detection equipment of the self-fluorescence tissue is started, an operator can send a control instruction to a control system through a human-machine interface (Human Machine Interface, HMI), and after the control instruction is received by the control system, the control system responds to the control instruction to determine the laser modulation frequency and sends a modulation signal carrying laser modulation frequency information to the laser modulation system. The laser modulation system modulates laser according to the modulation signal to obtain modulated laser, and emits the modulated laser through the probe laser emission channel. And the target optical signal of the current position contacted by the probe can also be received through the probe fluorescence receiving channel. And filtering the target optical signal by using a band-pass filter under the passband parameters to obtain a processed signal. And performing spectrum analysis on the processed signal, for example, converting the processed signal into an electric signal, converting the electric signal into a digital signal from an analog signal, obtaining a converted signal, converting the converted signal from a time domain into a frequency domain by utilizing Fourier transform, obtaining a spectrum of the processed signal, determining the spectrum intensity of the laser modulation spectrum according to the spectrum, and determining the spectrum intensity of the laser modulation spectrum as a fluorescent signal intensity value of the current position so as to judge whether the current position contacted by the probe belongs to the target position according to the fluorescent intensity value of the current position. And the frequency spectrum and the fluorescence signal intensity value can be sent to the control system and displayed on a display screen through an HMI human-machine interface.
Taking an execution subject as a server as an example, the detection method proposed in the present application is exemplarily described. In implementation, the server may acquire a light emitting signal of the light emitting device of the current detection scene, where the light emitting signal may be acquired and transmitted by the detection device of the self-fluorescent tissue, or may also be acquired and transmitted by another signal receiving device. The server performs spectrum analysis on the luminous signals, determines the interference frequency generated by the luminous device in the current detection scene, and determines the laser modulation frequency based on the interference frequency generated by the luminous device; wherein the laser modulation frequency is a frequency different from the interference frequency. The server can send the laser modulation frequency to the detection equipment of the self-fluorescence tissue, so that the detection equipment of the self-fluorescence tissue can modulate laser based on the laser modulation frequency, generate and send modulated laser, and the probe of the detection equipment of the self-fluorescence tissue can collect the target optical signal of the current contact part in real time and send the collected target optical signal to the server. The server further performs spectrum analysis on the target optical signal, determines a spectrum intensity value of the laser modulation frequency in the target optical signal, and determines the spectrum intensity value of the laser modulation frequency as a fluorescence intensity value of the current position; judging whether the current part contacted by the probe belongs to the target part of the human body or not according to the fluorescence intensity value of the current part, and if the current part is determined to belong to the target part, sending a control instruction by the server so that the detection equipment of the self-fluorescence tissue can send out a prompt tone when receiving the control instruction to prompt that the target part is detected.
The detection process of the detection device for autofluorescent tissue is described in more detail with reference to fig. 3. The detection process comprises the following steps:
and 1, starting the system.
And 2, inserting a probe.
And 3, enabling medical staff to contact the background position by using the probe.
And 4, the host acquires a background signal through the probe, and performs spectrum analysis on the background signal to determine the interference frequency.
The background signal is the luminous signal of the luminous device.
Step 5, according to the interference frequency, automatically selecting proper parameters, wherein the parameters comprise: the laser modulation frequency, the bandpass parameters of the bandpass filter.
And 6, medical staff select the non-self fluorescent tissue 1.
And 7, determining the fluorescence intensity 1 of the non-self-fluorescent tissue 1 by using the automatically selected parameters.
Wherein the non-self fluorescent tissue may be a predetermined location; determination of the fluorescence intensity 1 of the non-self-fluorescent tissue 1 reference is made to the procedure described above for determination of the fluorescence intensity value of the predetermined site, which is not described in detail here.
And 8, medical staff select the non-self fluorescent tissue 2.
And 9, determining the fluorescence intensity 2 of the non-self-fluorescent tissue 2 by using the automatically selected parameters.
Step 10, analogizing in sequence to obtain n fluorescence intensities, wherein n is a positive integer greater than 1.
And 11, calculating to obtain a median of the fluorescence intensity according to the n fluorescence intensities, and taking the median of the fluorescence intensity as a background value of the fluorescence intensity.
And 12, the medical staff contacts the current position by using the probe to obtain the fluorescence intensity value of the current position.
The procedure for determining the fluorescence intensity value of the current site may refer to the foregoing explanation of S105.
And step 13, judging whether the fluorescence intensity value of the current part is larger than the fluorescence intensity background value of the target multiple.
And step 14, if yes, determining that the current part belongs to the target part of the human body, and sending out a prompt tone by the host computer.
That is, the current part belongs to the self-fluorescence tissue, and the host machine sends out a prompt tone to prompt the medical staff that the current part belongs to the self-fluorescence tissue with high possibility.
If not, the medical staff can return to the step 12 to redetermine the fluorescence intensity value of the new part by moving the probe position until the target part is detected.
Based on the same inventive concept, the embodiment of the present application further provides an apparatus for detecting an auto-fluorescent tissue corresponding to the method for detecting an auto-fluorescent tissue, and since the principle of solving the problem by the apparatus in the embodiment of the present application is similar to that of the method for detecting an auto-fluorescent tissue described in the embodiment of the present application, the implementation of the apparatus may refer to the implementation of the method, and the repetition is omitted.
Referring to fig. 4, a schematic structural diagram of an apparatus for detecting an auto-fluorescent tissue according to an embodiment of the present application is shown, where the apparatus includes an obtaining module 401, a first determining module 402, a receiving module 403, a second determining module 404, and a judging module 405, where:
an acquisition module 401, configured to acquire a light-emitting signal of a light-emitting device of a current detection scene;
a first determining module 402, configured to perform spectrum analysis on the light-emitting signal, and determine an interference frequency generated by the light-emitting device in the current detection scene; and determining a laser modulation frequency based on the interference frequency generated by the light emitting device; wherein the laser modulation frequency is a different frequency than the interference frequency;
a receiving module 403, configured to modulate the laser based on the laser modulation frequency, and receive a target optical signal of a current position contacted by a probe of the detection device of the self-fluorescent tissue after generating and transmitting the modulated laser;
a second determining module 404, configured to perform spectrum analysis on the target optical signal, determine a spectrum intensity value of the laser modulation frequency in the target optical signal, and determine the spectrum intensity value of the laser modulation frequency as a fluorescence intensity value of the current location;
And the judging module 405 is configured to judge whether the current part contacted by the probe belongs to a target part of a human body according to the fluorescence intensity value of the current part, where the target part belongs to an auto-fluorescence tissue.
In an alternative embodiment, the first determining module 402 is configured to, when determining the laser modulation frequency based on the interference frequency generated by the light emitting device:
determining a frequency range according to the interference frequency generated by the light emitting device and a set frequency threshold, wherein the frequency range comprises: a first frequency range that is greater than a first frequency value, which is a frequency sum value between the interference frequency and the frequency threshold, and/or a second frequency range that is less than a second frequency value, which is a frequency difference value between the interference frequency and the frequency threshold;
and selecting the laser modulation frequency from the frequency range.
In an alternative embodiment, the determining module 405 is configured to, when determining, according to the fluorescence intensity value of the current location, whether the current location contacted by the probe belongs to a target location of a human body:
determining a fluorescence intensity background value corresponding to the current detection scene; the fluorescence intensity background value is used for representing reference fluorescence intensity values of other parts except the target part in the current detection scene;
And when the fluorescence intensity value of the current part is larger than the fluorescence intensity background value of the target multiple, determining that the current part contacted by the probe belongs to the target part of the human body.
In an alternative embodiment, the determining module 405 is configured to, when determining the fluorescence intensity background value corresponding to the current detection scene:
acquiring an optical signal of at least one preset part under the irradiation of the modulated laser;
performing spectrum analysis on the optical signal of the preset part to determine the fluorescence intensity value of the preset part;
and determining a fluorescence intensity background value corresponding to the current detection scene according to the fluorescence intensity value of the at least one preset part.
In an alternative embodiment, the determining module 405 is configured to determine the target multiple according to the following steps:
in response to a target operation triggered at a detection device of the self-fluorescent tissue, a target value input at the detection device of the self-fluorescent tissue is received and the target value is determined as the target multiple.
In an alternative embodiment, the apparatus further comprises: and the prompting module 406 is used for controlling the detection equipment of the self-fluorescence tissue to send out a prompting sound when the current part contacted by the probe is determined to belong to the target part.
In an alternative embodiment, the method further comprises: a processing module 407, configured to:
and determining passband parameters of a bandpass filter according to the laser modulation frequency and the frequency deviation value, wherein the passband parameters comprise: the band-pass filter allows a frequency range to pass, the maximum frequency of the frequency range is the frequency sum of the laser modulation frequency and the frequency deviation value, and the minimum frequency of the frequency range is the frequency difference between the laser modulation frequency and the frequency deviation value;
filtering the target optical signal by using the band-pass filter under the passband parameters to obtain a processed signal;
the second determining module 404 is configured to, when performing spectral analysis on the target optical signal: and carrying out spectrum analysis on the processed signal.
In an alternative embodiment, the target site comprises parathyroid glands and the light emitting device comprises a shadowless lamp.
In some embodiments, the functions or templates included in the apparatus provided in the embodiments of the present application may be used to perform the methods described in the foregoing method embodiments, and specific implementations thereof may refer to descriptions of the foregoing method embodiments, which are not repeated herein for brevity.
The description of the process flow of each component in the apparatus, and the interaction flow between components, is not meant to imply any limitation on the implementation by the exact process flow and interaction flow, which should be determined by the functions and possibly inherent logic thereof.
Based on the same technical concept, referring to fig. 5, an embodiment of the present application further provides an apparatus for detecting an auto-fluorescent tissue, including: a controller 501, a laser transmitter 502 and a probe 503; the laser transmitter 502 is configured to transmit the modulated laser under the control of the controller 501; the probe 503 is configured to collect a target optical signal of a current portion in contact, and send the target optical signal to the controller 501, where the target optical signal includes a fluorescent signal generated by the current portion under irradiation of the modulated laser; the controller 501 is configured to perform the above-described method for detecting an auto-fluorescent tissue.
The detection apparatus may further include a display screen that displays the setting interface under the control of the controller so that the controller can acquire a target value input at the setting interface and determine the target value as the target multiple. And the display screen can also display the target multiple, the spectrum obtained by spectrum analysis and the like, such as the spectrum of a target optical signal, the spectrum of an optical signal of a preset position and the like.
By way of example, a controller may include a processor, memory, and a bus. The memory is used for storing execution instructions, and comprises a memory and an external memory; the internal memory is also called an internal memory, and is used for temporarily storing operation data in the processor and data exchanged with an external memory such as a hard disk, the processor exchanges data with the external memory through the internal memory, and when the controller operates, the processor and the memory are communicated through a bus, so that the processor can execute the above-mentioned detection method of the autofluorescence organization.
Furthermore, the embodiment of the present application further provides a computer readable storage medium, on which a computer program is stored, which when executed by a processor performs the steps of the method for detecting an auto-fluorescent tissue described in the embodiment of the method. Wherein the storage medium may be a volatile or nonvolatile computer readable storage medium.
Embodiments of the present application also provide a computer program product comprising computer programs/instructions which, when executed, implement the method of detection of auto-fluorescence tissue as provided by the embodiments of the present application.
The methods of embodiments of the present application may be implemented in whole or in part by software, hardware, firmware, or any combination thereof. When implemented in software, may be implemented in whole or in part in the form of a computer program product. The computer program product includes one or more computer programs or instructions. When the computer program or instructions are loaded and executed on a computer, the processes or functions described herein are performed in whole or in part. The computer may be a general purpose computer, a special purpose computer, a computer network, a network device, a user device, a core network device, an OAM, or other programmable apparatus.
The computer program or instructions may be stored in a computer readable storage medium or transmitted from one computer readable storage medium to another computer readable storage medium, for example, the computer program or instructions may be transmitted from one website site, computer, server, or data center to another website site, computer, server, or data center by wired or wireless means. The computer readable storage medium may be any available medium that can be accessed by a computer or a data storage device such as a server, data center, etc. that integrates one or more available media. The usable medium may be a magnetic medium, e.g., floppy disk, hard disk, tape; but also optical media such as digital video discs; but also semiconductor media such as solid state disks. The computer readable storage medium may be volatile or nonvolatile storage medium, or may include both volatile and nonvolatile types of storage medium.
Finally, it should be noted that: the foregoing examples are merely specific embodiments of the present application, and are not intended to limit the scope of the present application, but the present application is not limited thereto, and those skilled in the art will appreciate that while the foregoing examples are described in detail, the present application is not limited thereto. Any person skilled in the art may modify or easily conceive of the technical solution described in the foregoing embodiments, or make equivalent substitutions for some of the technical features within the technical scope of the disclosure of the present application; such modifications, changes or substitutions do not depart from the spirit and scope of the technical solutions of the embodiments of the present application, and are intended to be included in the scope of the present application. Therefore, the protection scope of the present application shall be subject to the protection scope of the claims.
Claims (11)
1. A method for detecting an autofluorescent tissue, comprising:
acquiring a luminous signal of a luminous device of a current detection scene;
performing spectrum analysis on the luminous signals to determine the interference frequency generated by the luminous device in the current detection scene;
Determining a laser modulation frequency based on the interference frequency generated by the light emitting device; wherein the laser modulation frequency is a different frequency than the interference frequency;
modulating laser based on the laser modulation frequency, generating and transmitting modulated laser, and then receiving a target optical signal of the current part contacted by a probe of the detection equipment of the self-fluorescence tissue;
performing spectrum analysis on the target optical signal, determining a spectrum intensity value of the laser modulation frequency in the target optical signal, and determining the spectrum intensity value of the laser modulation frequency as a fluorescence intensity value of the current position;
judging whether the current part contacted by the probe belongs to a target part of a human body or not according to the fluorescence intensity value of the current part, wherein the target part belongs to an autofluorescence tissue.
2. The method of claim 1, wherein determining the laser modulation frequency based on the interference frequency generated by the light emitting device comprises:
determining a frequency range according to the interference frequency generated by the light emitting device and a set frequency threshold, wherein the frequency range comprises: a first frequency range that is greater than a first frequency value, which is a frequency sum value between the interference frequency and the frequency threshold, and/or a second frequency range that is less than a second frequency value, which is a frequency difference value between the interference frequency and the frequency threshold;
And selecting the laser modulation frequency from the frequency range.
3. The detection method according to claim 1, wherein the determining whether the current location contacted by the probe belongs to the target location of the human body according to the fluorescence intensity value of the current location comprises:
determining a fluorescence intensity background value corresponding to the current detection scene; the fluorescence intensity background value is used for representing reference fluorescence intensity values of other parts except the target part in the current detection scene;
and when the fluorescence intensity value of the current part is larger than the fluorescence intensity background value of the target multiple, determining that the current part contacted by the probe belongs to the target part of the human body.
4. The detection method according to claim 3, wherein determining the fluorescent intensity background value corresponding to the current detection scene includes:
acquiring an optical signal of at least one preset part under the irradiation of the modulated laser;
performing spectrum analysis on the optical signal of the preset part to determine the fluorescence intensity value of the preset part;
and determining a fluorescence intensity background value corresponding to the current detection scene according to the fluorescence intensity value of the at least one preset part.
5. A detection method according to claim 3, characterized in that the target multiple is determined according to the following steps:
in response to a target operation triggered by a detection device for the autofluorescent tissue, a target value input at the detection device for the autofluorescent tissue is received and the target value is determined as the target multiple.
6. The method of probing as recited in claim 1 wherein the method further comprises:
and when the current part contacted by the probe is determined to belong to the target part, controlling the detection equipment of the self-fluorescence tissue to send out a prompt tone.
7. The detection method according to claim 1, further comprising:
and determining passband parameters of a bandpass filter according to the laser modulation frequency and the frequency deviation value, wherein the passband parameters comprise: the band-pass filter allows a frequency range to pass, the maximum frequency of the frequency range is the frequency sum of the laser modulation frequency and the frequency deviation value, and the minimum frequency of the frequency range is the frequency difference between the laser modulation frequency and the frequency deviation value;
filtering the target optical signal by using the band-pass filter under the passband parameters to obtain a processed signal;
The performing spectrum analysis on the target optical signal includes:
and carrying out spectrum analysis on the processed signal.
8. The method of claim 1, wherein the target site comprises parathyroid glands and the light emitting device comprises a shadowless lamp.
9. An apparatus for detecting self-fluorescent tissue, comprising: the device comprises a controller, a laser emitter and a probe; the laser transmitter is used for transmitting modulated laser under the control of the controller; the probe is used for collecting a target optical signal of a current part in contact and sending the target optical signal to the controller, and the target optical signal comprises a fluorescent signal generated by the current part under the irradiation of the modulated laser; the controller for performing the method for detecting an autofluorescent tissue according to any one of claims 1 to 8.
10. An apparatus for detecting an autofluorescent tissue, comprising:
the acquisition module is used for acquiring a luminous signal of the luminous device of the current detection scene;
the first determining module is used for carrying out spectrum analysis on the luminous signals and determining the interference frequency generated by the luminous device in the current detection scene; and determining a laser modulation frequency based on the interference frequency generated by the light emitting device; wherein the laser modulation frequency is a different frequency than the interference frequency;
The receiving module is used for modulating the laser based on the laser modulation frequency, generating and transmitting modulated laser and then receiving a target optical signal of the current position contacted by the probe of the detection equipment of the self-fluorescence tissue;
the second determining module is used for carrying out spectrum analysis on the target optical signal, determining a spectrum intensity value of the laser modulation frequency in the target optical signal, and determining the spectrum intensity value of the laser modulation frequency as a fluorescence intensity value of the current position;
and the judging module is used for judging whether the current part contacted by the probe belongs to a target part of a human body or not according to the fluorescence intensity value of the current part, and the target part belongs to an autofluorescence tissue.
11. A computer-readable storage medium, characterized in that the computer-readable storage medium has stored thereon a computer program which, when executed by a processor, performs the steps of the method for detecting an autofluorescent tissue according to any one of claims 1 to 8.
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