CN112826452A - Double-laser excitation system for parathyroid gland recognition - Google Patents
Double-laser excitation system for parathyroid gland recognition Download PDFInfo
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- CN112826452A CN112826452A CN202110362386.0A CN202110362386A CN112826452A CN 112826452 A CN112826452 A CN 112826452A CN 202110362386 A CN202110362386 A CN 202110362386A CN 112826452 A CN112826452 A CN 112826452A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7235—Details of waveform analysis
- A61B5/7253—Details of waveform analysis characterised by using transforms
- A61B5/7257—Details of waveform analysis characterised by using transforms using Fourier transforms
Abstract
The invention relates to a double laser excitation system for parathyroid gland identification, which comprises: the microprocessor is used for outputting modulation signals within 1 kHz-100 kHz, is connected to the near-infrared laser and the visible light laser and is used for controlling the near-infrared laser and the visible light laser to output laser corresponding to the modulation signals, the near-infrared laser and the visible light laser are respectively connected to the first dichroic mirror, the output end of the first dichroic mirror is coupled to one beam of optical fibers through the coupling lens, the optical fibers are connected with the probe, and the lower part of the probe is aligned to a tissue to be detected; the other beam of light in the probe is coupled to the collimating lens, a photoelectric measuring device is connected behind the collimating lens, the photoelectric measuring device is a double-path laser simultaneous detection photoelectric measuring device or a double-path laser time-sharing detection photoelectric measuring device, and the photoelectric measuring device is connected to the acousto-optic alarm display device.
Description
Technical Field
The application relates to the technical field of biological tissue identification, in particular to a double-laser excitation system for parathyroid gland identification, which can be used for positioning parathyroid gland in operation.
Background
The incidence of thyroid diseases in the world rises rapidly, and the incidence of thyroid cancer in some provinces and cities of China enters the first ten malignant tumor incidences. Thyroidectomy is a common surgical procedure for removing all or part of the thyroid gland for the treatment of thyroid disorders including thyroid cancer, hyperthyroidism and multinodular goiter. Parathyroid gland is a gland of soybean size located on thyroid gland, and plays an important role in regulating blood calcium, and miscut in operation can cause serious complications, and if miscut is judged by pathological sections, doctors need to perform autografting in time.
It has been found that parathyroid gland can emit 2 to 10 times more fluorescence than peripheral tissues under laser irradiation. Based on this principle, the parathyroid gland recognition system designed at present mainly has two forms of image and probe. The image is easily influenced by ambient light, and the doctor is required to turn off all lights in the operating room during the operation. The probe point detection system is not sensitive to ambient light, but is affected by a shadowless lamp overlapped with a fluorescence waveband, a doctor is required to turn off the shadowless lamp for use, and certain inconvenience is caused to the operation flow, and the design of frequency modulation exciting light (publication number: CN111343910A [0035]) is proposed by Kangqing university Mitsuan scientific and technical institute, but a phase-locked amplifier is required to extract signals, so that the complexity and cost of the system are increased invisibly. In addition, researches show that except for the parathyroid gland, tissues burnt by high temperature in the operation also have near infrared fluorescence, the burnt tissues can cause the false judgment of doctors as the parathyroid gland, the false positive identification rate of the parathyroid gland is increased, and further serious results are generated, and the problem cannot be solved by the pure frequency modulation and phase-locked loop design.
Disclosure of Invention
The invention aims to provide a parathyroid gland identification system based on near-infrared autofluorescence, which reduces the influence of ambient light and a shadowless lamp in an operation and enables a doctor to detect the parathyroid gland without changing the existing operation process. Meanwhile, the burned tissue and the parathyroid gland are distinguished in the operation through the difference of the autofluorescence intensity of the burned tissue and the parathyroid gland in visible light and near infrared bands, and the false positive rate of parathyroid gland identification is reduced.
According to the characteristic that the ambient light and the shadowless lamp are direct currents, the parathyroid gland recognition system based on modulated exciting light is designed, the modulation frequency is far higher than that of a common 50Hz or 60Hz mains supply, autofluorescence is converted into an electric signal through a photoelectric sensor such as APD or PMT and then collected, the signal directly enters a micro-processor without a phase-locked amplifier to be subjected to Fourier transform to extract the amplitude of the fluorescence signal at the modulation frequency, and therefore ambient light interference of the direct current shadowless lamp and power frequency alternating current is removed. A commonly used microprocessor is a DSP digital signal processor, which is suitable for fast signal processing, such as FFT fast fourier operations. The DSP can also be used as a universal controller for controlling the sound box or the liquid crystal screen and outputting the detection result.
According to the obvious intensity difference of autofluorescence of burned tissues and parathyroid gland in visible light wave bands, a parathyroid gland recognition system with double excitation lights is designed, except common near-infrared excitation lights, visible light excitation lights with wave bands of 500nm are added, in the aspect of system design, a mode of simultaneously exciting two lasers or multiplexing systems in a time-sharing mode can be adopted, so that the burned tissues and the parathyroid glands are correctly distinguished, and the two systems are described in an implementation case.
The technical scheme of the invention is a double-laser excitation system for parathyroid gland identification, which comprises: the microprocessor is used for outputting modulation signals within 1 kHz-100 kHz, is connected to the near-infrared laser and the visible light laser and is used for controlling the near-infrared laser and the visible light laser to output laser corresponding to the modulation signals, the near-infrared laser and the visible light laser are respectively connected to the first dichroic mirror, the output end of the first dichroic mirror is coupled to one beam of optical fibers through the coupling lens, the optical fibers are connected with the probe, and the lower part of the probe is aligned to a tissue to be detected; the other beam of light in the probe is coupled to the collimating lens, a photoelectric measuring device is connected behind the collimating lens, the photoelectric measuring device is a double-path laser simultaneous detection photoelectric measuring device or a double-path laser time-sharing detection photoelectric measuring device, and the photoelectric measuring device is connected to the acousto-optic alarm display device.
Further, the two-way laser simultaneous detection photoelectric measurement system comprises:
the second secondary partial mirror is used for dividing the light into two paths which are respectively connected to the visible light wave band optical filter and the near infrared optical filter, the visible light wave band optical filter is connected to the second condenser lens, and the light beams are focused on the second photoelectric detector and converted into electric signals which are then collected by the microprocessor; the near-infrared filter is connected to the first condenser lens and then focused on the first photoelectric detector, and optical signals are converted into electric signals and then collected by the microprocessor.
Further, the two-way laser time-sharing detection photoelectric measurement system comprises:
the double-color filter roller is connected to the microprocessor, and the microprocessor is used for controlling the double-color filter roller to rotate to the near-infrared filter or the visible light filter; the output end of the double-color filter roller is connected to the photoelectric detector, and the light signal is converted into an electric signal to be collected by the microprocessor.
Furthermore, two paths of laser output by the near-infrared laser and the visible laser become coaxial through the first dichroic mirror, and then are coupled into the optical fiber through the coupling lens, and the coupled laser excites the tissue to be detected to generate fluorescence after being conducted through the optical fiber and the probe; the generated fluorescence is transmitted to the collimating lens through the optical fiber and then is changed into parallel light, and is divided into two paths of light through the second half mirror, wherein one path of light enters the visible light wave band optical filter, the other path of light enters the near infrared optical filter for filtering, and the former path of light enters the second condensing lens and then is focused on the second photoelectric detector to be converted into an electric signal and then is collected by the microprocessor; the latter enters a first condenser lens, is focused on a first photoelectric detector, is converted into an electric signal, and is collected by a microprocessor, wherein the photoelectric detector is typically an APD avalanche photodiode. The microprocessor carries out spectrum analysis on the collected signals, extracts the signal amplitude at the position corresponding to the modulation frequency, carries out result judgment, displays the identified result through the acousto-optic alarm device, and gives out preset sound when the instrument determines that the parathyroid gland is present.
Further, the microprocessor controls the double-color filter roller to select the optical filter, when near-infrared fluorescence needs to be detected, the double-color filter roller rotates to the near-infrared optical filter, and when visible fluorescence needs to be detected, the double-color filter roller rotates to the visible optical filter; the filtered optical signal is converted into an electric signal through a photoelectric detector and is collected by a microprocessor, the microprocessor performs spectrum analysis on the collected signal, extracts a signal amplitude at a position corresponding to a modulation frequency, performs result judgment according to a flow chart, displays the identified result through an acousto-optic alarm device, and gives out a preset sound when the instrument confirms that the instrument is the parathyroid gland.
Furthermore, the wave band of the near-infrared laser is 750nm to 790nm, and the wave band of the visible light laser is 480nm to 520 nm.
Furthermore, the first dichroic mirror is a high-pass low-reflection lens, and the coupling lens is a cemented achromat lens.
Further, the photodetector is an APD avalanche photodiode.
Furthermore, the optical fiber is a Y-shaped optical fiber with double 200um core diameters.
Further, the second half mirror is typically a high-pass low-reflection lens.
Has the advantages that:
compared with the prior art, the invention has the following advantages:
firstly, the method of combining the modulated excitation light and the Fourier algorithm for frequency spectrum analysis is adopted, so that the influence of the ambient light and the direct-current shadowless lamp can be easily removed, the use of a phase-locked amplifier is reduced on hardware, and the cost of a detection system can be reduced.
Secondly, the invention adopts the design of double exciting lights, can distinguish burned tissues and parathyroid gland in the operation, and reduces the false positive identification rate of parathyroid gland brought by the burned tissues.
Drawings
FIG. 1: fluorescence imaging images of parathyroid gland and burned tissues under the excitation of near-infrared excitation light and visible light, (a) fluorescence imaging images under the excitation of near-infrared excitation light, and (b) fluorescence imaging images under the excitation of visible light;
FIG. 2: time domain and frequency domain signal diagrams of muscle tissue and parathyroid gland under 60KHz modulation, wherein fig. 2(a) is a time domain signal diagram of the muscle tissue, fig. 2(b) is a frequency domain signal diagram obtained after corresponding signals are subjected to fast Fourier transform, fig. 2(c) is a time domain signal diagram of the parathyroid gland tissue, and fig. 2(d) is a frequency domain signal diagram obtained after corresponding signals are subjected to fast Fourier transform.
FIG. 3: burned tissue and parathyroid gland identification procedures;
FIG. 4: a system schematic block diagram of two paths of exciting lights working simultaneously;
FIG. 5: and (3) a double-laser time-sharing excitation system diagram.
Description of the reference numerals
1: audible and visual alarm display device 2: microprocessor
3: first photodetector 4: second photo detector
5: first condenser lens 6: optical fiber
7: near-infrared band filter 8: visible light wave band filter
9: second condenser lens 10: second half mirror
11: collimator lens 12: coupling lens
13: near-infrared laser 14: first and second dichroic mirror
15: visible light laser 16: probe needle
17: tissue to be detected 18: double-color filter roller
Detailed Description
The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, rather than all embodiments, and all other embodiments obtained by a person skilled in the art based on the embodiments of the present invention belong to the protection scope of the present invention without creative efforts.
According to the embodiment of the invention, a double-laser excitation system for parathyroid gland identification is provided, the system is based on modulated excitation light, the modulation frequency is far higher than that of common commercial power of 50Hz or 60Hz, autofluorescence is converted into an electric signal through a photoelectric sensor, such as APD or PMT, and then the electric signal is collected, the signal directly enters a micro-processor without a phase-locked amplifier to carry out Fourier transform to extract the amplitude of the fluorescence signal at the modulation frequency, and therefore, the interference of direct current shadowless lamps and power frequency alternating-current ambient light is removed. A commonly used microprocessor is a DSP digital signal processor, which is suitable for fast signal processing, such as FFT fast fourier operations. The DSP can also be used as a universal controller for controlling the sound box or the liquid crystal screen and outputting the detection result.
According to the obvious intensity difference of autofluorescence of burned tissues and parathyroid gland in visible light wave bands, a parathyroid gland recognition system with double excitation lights is designed, except common near-infrared excitation lights, visible light excitation lights with wave bands of 500nm are added, in the aspect of system design, a mode of simultaneously exciting two lasers or multiplexing systems in a time-sharing mode can be adopted, so that the burned tissues and the parathyroid glands are correctly distinguished, and the two systems are described in an implementation case.
FIG. 1 is a graph showing fluorescence images of a burned tissue and parathyroid gland under excitation of near-infrared excitation light and visible light, wherein FIG. 1(a) is a graph showing fluorescence images under excitation of near-infrared excitation light, in which both the burned tissue and the visible parathyroid gland exhibit significant fluorescence. FIG. 1(b) is a fluorescence image under excitation of visible light, showing that burned tissue has strong fluorescence but parathyroid gland has no obvious fluorescence.
Fig. 2 shows time-domain and frequency-domain signal diagrams of muscle tissue and parathyroid gland under 60KHz modulation, wherein fig. 2(a) is a time-domain signal diagram of muscle tissue, fig. 2(b) is a frequency-domain signal diagram obtained after corresponding signals are subjected to fast fourier transform, fig. 2(c) is a time-domain signal diagram of parathyroid gland tissue, and fig. 2(d) is a frequency-domain signal diagram obtained after corresponding signals are subjected to fast fourier transform. The amplitudes corresponding to 60KHz in the frequency domain are compared, and interference signals of other wave bands can be filtered.
The present invention can adopt two embodiments of fig. 4 and 5, and the two systems mainly differ in the fluorescence collection part. In fig. 4, a double light path is adopted to simultaneously realize the fluorescence excitation and detection of near infrared and visible light, and in fig. 5, a single light path is adopted to realize the time-sharing excitation and detection of two kinds of fluorescence by using a double-color filter roller.
The first embodiment is as follows: double-laser simultaneous excitation system
According to the first embodiment of the present invention, as shown in fig. 4, a diagram of a dual laser simultaneous excitation system is provided, the system includes an acousto-optic alarm display device 1, a microprocessor 2, a first photodetector 3, a second photodetector 4, a first condenser lens 5, an optical fiber 6, a near-infrared band filter 7, a visible band filter 8, a second condenser lens 9, a second dichroic mirror 10, a collimating lens 11, a coupling lens 12, a near-infrared laser 13, a first dichroic mirror 14, a visible laser 15, a probe 16, and a tissue to be detected 17.
The microprocessor 2, typically a DSP digital signal processor, outputs a modulation signal within 100KHz, such as a 60KHz square wave signal or a sine wave signal, and controls the near-infrared laser 13 and the visible light laser 15 to output laser light corresponding to the modulation signal, where a typical band of the near-infrared laser 13 is 785nm, and a typical band of the visible light laser 15 is 500 nm. The output laser is changed into coaxial laser (namely two laser paths, one laser path is reflected and the other laser path is transmitted to finally synthesize a coaxial light path) through the first dichroic mirror 14, the coaxial laser is coupled into the optical fiber 6 through the coupling lens 12, the first dichroic mirror 14 is typically a high-pass low-reflection (the high-pass low-reflection means that high frequency passes low-frequency reflection) lens, the coupling lens 12 is typically a cemented achromatism lens, the optical fiber 6 is typically a Y-shaped optical fiber with double 200um core diameters, and the coupled laser excites the tissue to be detected 17 to generate fluorescence after being transmitted through the optical fiber 6 and the probe 16. The generated fluorescence is transmitted to the collimating lens 11 through the optical fiber 6 to become parallel light, and is divided into two paths of light through the second partial mirror 10, the second partial mirror 10 is typically a high-pass low-reflection lens, one path of light enters the visible light band optical filter 8, the other path of light enters the near-infrared band optical filter 7 for filtering, and the former enters the second condensing lens 9 and is focused on the second photoelectric detector 4 to be converted into an electric signal, and then the electric signal is collected by the microprocessor 2. The latter enters a first condenser lens 5 and is focused on a first photodetector 3 to be converted into an electric signal, and then the electric signal is collected by a microprocessor 2, wherein the second photodetector 4 and the first photodetector 3 are typically APD avalanche photodiodes. The microprocessor 2 carries out spectrum analysis on the collected signals, extracts the signal amplitude at the modulation frequency of 60KHz, judges the result according to the flow chart 3, displays the identified result through the acousto-optic alarm display device 1, and gives out specific sound when the instrument determines that the instrument is parathyroid.
Example two: double-laser time-sharing excitation system
Fig. 5 shows a double-laser time-sharing excitation system, which includes an acousto-optic alarm display device 1, a microprocessor 2, a first photodetector 3, a first condenser lens 5, an optical fiber 6, a collimating lens 11, a coupling lens 12, a near-infrared laser 13, a first dichroic mirror 14, a visible light laser 15, a probe 16, a tissue to be detected 17, and a double-color filter roller 18. The microprocessor 2, typically a DSP digital processor, outputs a modulation signal within 100KHz, for example, a 60KHz square wave signal, and controls the near-infrared laser 13 and the visible light laser 15 to output laser light corresponding to the modulation signal, where a typical wavelength band of the near-infrared laser 13 is 785nm, and a typical wavelength band of the visible light laser 15 is 500 nm. The output laser is changed into a coaxial laser through a first dichroic mirror 14 and then coupled into an optical fiber 6 through a coupling lens 12, the dichroic mirror 14 is typically a high-pass low-reflection lens, the coupling lens 12 is typically a cemented achromat, the optical fiber 6 is typically a double 200um core diameter Y-shaped optical fiber, and the coupled laser excites the tissue 17 to be detected to generate fluorescence after being conducted through the optical fiber 6 and a probe 16. The generated fluorescence is transmitted to the collimating lens 11 through the optical fiber 6 and then becomes parallel light to be filtered, the microprocessor 2 controls the double-color filter roller 18 to select the optical filter, when near-infrared fluorescence needs to be detected, the double-color filter roller 18 rotates to the near-infrared optical filter, and when visible light fluorescence needs to be detected, the double-color filter roller 18 rotates to the visible light optical filter. The filtered optical signal is converted to an electrical signal by a photodetector 3, typically an APD avalanche photodiode, and collected by the microprocessor 2. The microprocessor 2 carries out spectrum analysis on the collected signals, extracts the signal amplitude at the modulation frequency of 60KHz, judges the result according to the flow chart 3, displays the identified result through the acousto-optic alarm display device 1, and gives out specific sound when the instrument determines that the instrument is parathyroid.
As shown in fig. 3, which is a flow chart of identifying burned tissues and parathyroid glands, the flow chart corresponds to a flow chart of identifying burned tissues and parathyroid glands by time division multiplexing, and for the mode of exciting light simultaneously, the judgment steps of 300 and 600 in the flow chart can be combined, and the judgment of judging visible light and near infrared light can be carried out simultaneously.
The detection flow of fig. 4 is further described herein.
The microprocessor 2, typically a DSP digital processor, outputs a modulation signal within 100KHz, for example, a 60KHz square wave signal, and controls the near-infrared laser 13 and the visible light laser 15 to output laser light corresponding to the modulation signal. The output laser is changed into a coaxial laser through the first dichroic mirror 14 and then coupled into the optical fiber 6 through the coupling lens 12, and the coupled laser is transmitted through the optical fiber 6 and the probe 16 and then excites the tissue to be detected 17 to generate fluorescence. The generated fluorescence is transmitted to a collimating lens 11 through an optical fiber 6 to become parallel light, and is divided into two paths of light through a second partial mirror 10, wherein one path of light enters a visible light band optical filter 8, the other path of light enters a near infrared band optical filter 7 for filtering, and the former path of light enters a second condenser lens 9 and is focused on a second photoelectric detector 4 to be converted into an electric signal which is collected by a microprocessor 2. The latter enters a first condenser lens 5 and is focused on a first photoelectric detector 3 to be converted into an electric signal which is collected by a microprocessor 2. The microprocessor 2 performs spectrum analysis on the acquired signal, extracts the signal amplitude at the modulation frequency, performs result judgment according to the flow chart 3, and displays the identified result through the sound-light alarm display device 1.
Although illustrative embodiments of the present invention have been described above to facilitate the understanding of the present invention by those skilled in the art, it should be understood that the present invention is not limited to the scope of the embodiments, but various changes may be apparent to those skilled in the art, and it is intended that all inventive concepts utilizing the inventive concepts set forth herein be protected without departing from the spirit and scope of the present invention as defined and limited by the appended claims.
Claims (10)
1. A dual laser excitation system for parathyroid gland identification, comprising: the microprocessor is used for outputting modulation signals within 1 kHz-100 kHz, is connected to the near-infrared laser and the visible light laser and is used for controlling the near-infrared laser and the visible light laser to output laser corresponding to the modulation signals, the near-infrared laser and the visible light laser are respectively connected to the first dichroic mirror, the output end of the first dichroic mirror is coupled to one beam of optical fibers through the coupling lens, the optical fibers are connected with the probe, and the lower part of the probe is aligned to a tissue to be detected; the other beam of light in the probe is coupled to the collimating lens, a photoelectric measuring device is connected behind the collimating lens, the photoelectric measuring device is a double-path laser simultaneous detection photoelectric measuring device or a double-path laser time-sharing detection photoelectric measuring device, and the photoelectric measuring device is connected to the acousto-optic alarm display device.
2. The dual laser excitation system for parathyroid gland identification according to claim 1, wherein the dual laser simultaneous detection photoelectric measurement system comprises:
the second secondary partial mirror is used for dividing the light into two paths which are respectively connected to the visible light wave band optical filter and the near infrared optical filter, the visible light wave band optical filter is connected to the second condenser lens, and the light beams are focused on the second photoelectric detector and converted into electric signals which are then collected by the microprocessor; the near-infrared filter is connected to the first condenser lens and then focused on the first photoelectric detector, and optical signals are converted into electric signals and then collected by the microprocessor.
3. The dual laser excitation system for parathyroid gland identification according to claim 1, wherein the dual laser time-sharing detection photoelectric measurement system comprises:
the double-color filter roller is connected to the microprocessor, and the microprocessor is used for controlling the double-color filter roller to rotate to the near-infrared filter or the visible light filter; the output end of the double-color filter roller is connected to the photoelectric detector, and the light signal is converted into an electric signal to be collected by the microprocessor.
4. A dual laser excitation system for parathyroid gland identification according to claim 2,
two paths of laser output by the near infrared laser and the visible light laser become coaxial through the first dichroic mirror, and then are coupled into the optical fiber through the coupling lens, and the coupled laser excites the tissue to be detected to generate fluorescence after being conducted through the optical fiber and the probe; the generated fluorescence is transmitted to the collimating lens through the optical fiber and then is changed into parallel light, and is divided into two paths of light through the second half mirror, wherein one path of light enters the visible light wave band optical filter, the other path of light enters the near infrared optical filter for filtering, and the former path of light enters the second condensing lens and then is focused on the second photoelectric detector to be converted into an electric signal and then is collected by the microprocessor; the photoelectric detector enters a first condenser lens, is focused on a first photoelectric detector, is converted into an electric signal, and is collected by a microprocessor, wherein the photoelectric detector and a typical APD avalanche photodiode are arranged in the photoelectric detector; the microprocessor carries out spectrum analysis on the collected signals, extracts the signal amplitude at the position corresponding to the modulation frequency, carries out result judgment, displays the identified result through the acousto-optic alarm device, and gives out preset sound when the instrument determines that the parathyroid gland is present.
5. A dual laser excitation system for parathyroid gland identification according to claim 3,
the microprocessor controls the double-color filter roller to select the optical filter, when near-infrared fluorescence needs to be detected, the double-color filter roller rotates to the near-infrared optical filter, and when visible fluorescence needs to be detected, the double-color filter roller rotates to the visible optical filter; the filtered optical signal is converted into an electric signal through a photoelectric detector and is collected by a microprocessor, the microprocessor performs spectrum analysis on the collected signal, extracts a signal amplitude at a position corresponding to a modulation frequency, performs result judgment according to a flow chart, displays the identified result through an acousto-optic alarm device, and gives out a preset sound when the instrument confirms that the instrument is the parathyroid gland.
6. A dual laser excitation system for parathyroid gland identification according to claim 1,
the wave band of the near-infrared laser is 750nm to 790nm, and the wave band of the visible light laser is 480nm to 520 nm.
7. A dual laser excitation system for parathyroid gland identification according to claim 1,
the first dichroic mirror is a high-pass low-reflection lens, and the coupling lens is a cemented achromat.
8. A dual laser excitation system for parathyroid gland identification according to claim 1,
the photodetector is an APD avalanche photodiode.
9. A dual laser excitation system for parathyroid gland identification according to claim 1,
the optical fiber is a Y-shaped optical fiber with double 200um core diameters.
10. A dual laser excitation system for parathyroid gland identification according to claim 1,
the second half mirror is typically a high-pass low-reflection lens.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114711727A (en) * | 2022-05-09 | 2022-07-08 | 江苏百宁盈创医疗科技有限公司 | Novel parathyroid gland detecting device |
| CN114748042A (en) * | 2022-05-09 | 2022-07-15 | 江苏百宁盈创医疗科技有限公司 | Parathyroid gland detection device based on L-shaped light path |
-
2021
- 2021-04-02 CN CN202110362386.0A patent/CN112826452A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114711727A (en) * | 2022-05-09 | 2022-07-08 | 江苏百宁盈创医疗科技有限公司 | Novel parathyroid gland detecting device |
| CN114748042A (en) * | 2022-05-09 | 2022-07-15 | 江苏百宁盈创医疗科技有限公司 | Parathyroid gland detection device based on L-shaped light path |
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