CN114748042A

CN114748042A - Parathyroid gland detection device based on L-shaped light path

Info

Publication number: CN114748042A
Application number: CN202210498361.8A
Authority: CN
Inventors: 陈亮; 李健聪
Original assignee: Jiangsu Baining Yingchuang Medical Technology Co ltd
Current assignee: Jiangsu Baining Yingchuang Medical Technology Co ltd
Priority date: 2022-05-09
Filing date: 2022-05-09
Publication date: 2022-07-15

Abstract

The invention discloses a parathyroid gland detection device based on an L-shaped light path, which consists of a probe, a handle, an optical fiber cable and a portable host, wherein the portable host is internally provided with the L-shaped light path so that a transmitting laser and a receiving fluorescent signal are transmitted through the same optical fiber, the top end of the probe is provided with a probe lens, and the probe adopts a replaceable design. The invention can improve the effective utilization rate of exciting light, improve laser density and enhance fluorescence signal intensity, thereby improving parathyroid gland detection recognition rate, and can realize disposable aseptic operation, thus having great clinical significance.

Description

Parathyroid gland detection device based on L-shaped light path

Technical Field

The invention relates to the field of medical instruments, in particular to a parathyroid gland detection device based on an L-shaped light path.

Background

Two pairs of parathyroid hormone (PTH for short) are present in human body, are brown yellow like soybean, are respectively located in the middle and lower parts of the back (or embedded in) of the thyroid gland of left and right lobes, and have the main functions of secreting parathyroid hormone (PTH for short) and regulating the bodyCalcium (ll) containing calcium (II)And phosphorus metabolism. Hypoparathyroidism or complete removal of the parathyroid gland (such as an inadvertent withdrawal during a thyroid surgery) results in hyposecretion of PTH, which causes gradual decrease in blood calcium and gradual increase in blood phosphorus, resulting in hypocalcemic convulsions and even death, and temporary relief of symptoms by supplementing PTH and calcium salts. Since parathyroid gland weighs 35-45mg and is about 2x3x4mm, its size is very small and the location of the paraglandular gland is not constant: upper lateral gland position Relatively constant, about 77% located near the cricothyroid joint, 22% located posttransthyretin, and only about 1% located postpharyngeal, postesophageal; the lower gland has great position change, 42 percent of the lower gland is positioned on the front and back of the hypothyroid, 39 percent of the lower gland is positioned at the thymic tongue (namely, the pectoralis ligament is used for searching for the lateral gland), 2 percent of the lower gland is positioned in the upper mediastinal thymus, 15 percent of the lower gland is positioned at the tracheoesophageal sulcus near the thyroid gland body, and 2 percent of the lower gland has variation, so that in the thyroidectomy for removing thyroid gland tumors, the parathyroid gland, the thyroid gland, fat and other peripheral tissues are difficult to distinguish by naked eyes, and great hidden danger is brought. According to related researches at home and abroad, the parathyroid gland can generate a basic principle of fluorescence with a peak value between 820 nm and 830nm under the excitation of 785nm laser. Related implementation modes of parathyroid gland detection devices disclosed in the current market respectively realize laser transmission and fluorescence signal reception by two optical fibers, namely one emitting optical fiber and one receiving optical fiber. The disadvantages of this method are the following three points:

1. although the positions of the receiving end and the transmitting end are very close to each other, the two optical fibers still have position deviation, most of the vertically reflected fluorescent signals enter the transmitting end in the actual use process, and the fluorescent signals entering the receiving end are very weak in practice, so that the performance of the light sensation element is extremely excellent, the subsequent circuit processing requirements are high, the complexity of the system is increased, and the identification rate of parathyroid gland detection and the comprehensive benefits of the system are influenced finally;

2. Laser can be diffused after being emitted from the emitting optical fiber, so that the optical density of the laser is weakened, the excitation efficiency of fluorescence is influenced, the excitation effect is not ideal, and the detection rate of parathyroid gland is also influenced;

3. the existing product is high in price, disposable sterile use cannot be realized, the operation time is prolonged, and the operation efficiency is reduced.

Disclosure of Invention

The invention provides a parathyroid gland detection device based on an L-shaped light path, which aims at solving the problems that the existing products in the market at present have low received light intensity, poor sexual noise ratio, large emitted light divergence angle, complex system, incapability of realizing one-time sterile use and the like, and not only improves the laser density to enhance the fluorescence signal intensity, greatly improves the parathyroid gland detection recognition rate, can obviously distinguish peripheral tissues such as parathyroid gland, thyroid gland, fat and the like, but also can realize sterile operation and has great clinical significance.

The technical scheme adopted by the invention for solving the technical problems is as follows: the utility model provides a parathyroid gland detection device based on L type light path comprises probe, handle, optic fibre cable and portable host computer, characterized by: the portable host consists of an L-shaped light path, a laser emission unit, a fluorescence detection unit and a controller, wherein the L-shaped light path has the structure that: the X-axis and the Y-axis are respectively vertical to each other, the No. 2 lens, the dichroic mirror, the fluorescent light filter, the No. 3 lens and the photoelectric sensor are sequentially arranged on the X-axis, and the laser light source, the No. 1 lens, the laser light filter and the dichroic mirror are sequentially arranged on the Y-axis.

Preferably, the optical fiber cable is a single optical fiber.

Preferably, the probe tip is provided with a probe lens.

Preferably, the probe is movably connected with the handle, and the probe is directly coupled with the optical fiber cable at the joint of the handle.

Preferably, the portable host computer is provided with a battery.

The dichroic mirror is placed at the intersection point of the two axes, can refract laser light in a laser wave band, can transmit fluorescence in a fluorescence wave band, the No. 1 lens collimates emitted laser light, the No. 2 lens focuses the emitted laser light on an optical fiber and collimates received fluorescence signals, and the No. 3 lens focuses the received fluorescence signals on the photoelectric sensor.

The L-shaped optical path has the following advantages:

1. laser signals can be refracted out by using the refraction principle of the dichroic mirror, and then the filtering effect of the fluorescent filter in the later period is utilized, so that the interference of the laser signals is eliminated to the greatest extent, and the expected fluorescent signals are filtered out;

2. the coupling efficiency is high, the convex lens light-gathering principle is utilized, the effective utilization rate of laser can be improved, the laser density is improved, fluorescent signals can be collected as much as possible, and finally, the fluorescent signals are focused on a photoelectric sensor;

3. the single optical fiber design can be adopted by the optical fiber cable, so that the aperture of the optical fiber can be increased, the fluorescence receiving efficiency can be improved, more fluorescence signals can be received, the emitting end face and the receiving end face of the single optical fiber are designed to be the same end face, the receiving end face can receive all the fluorescence signals reflected vertically, and the emitting end face and the receiving end face of the optical fiber are coplanar and can be simultaneously positioned at the focal position of the probe lens, so that the laser density is improved, the fluorescence signal intensity is enhanced, and the design of multiple optical fibers cannot be realized.

The probe lens can focus the emitted laser to a tissue to be detected to improve the laser intensity, and can also focus and transmit weak fluorescent signals which are difficult to detect on the side to the optical fiber.

One end of the optical fiber cable penetrating through the handle is positioned at the focus position of the probe lens, and the other end of the optical fiber cable is positioned at the focus position of the No. 2 lens in the L-shaped light path.

The controller demodulates the optical signal through a phase-locked amplification technology, and the influence of the background light of the operation environment is avoided.

The beneficial effects of the invention are:

1. the effective utilization rate of laser can be improved, the laser density is improved, the fluorescence signal intensity is enhanced, and the parathyroid gland detection recognition rate is greatly improved;

2. weak fluorescent signals can be detected quickly, and the influence of the background light of the operation environment is not feared;

3. the disposable sterilization consumable design can reduce the risk of cross infection to the maximum extent without sterilization during clinical use, and has the advantages of convenience, sanitation and high economic benefit.

Drawings

FIG. 1 is a schematic diagram of the present invention.

Fig. 2 is a schematic cross-sectional view 300.

Fig. 3 is a schematic diagram of an L-shaped optical path and an optical path used in the present invention.

Fig. 4 is a schematic diagram of the working principle of the present invention.

FIG. 5 is a schematic structural view of embodiment 1.

FIG. 6 is a schematic view of the structure of embodiment 2.

In the figure, a lens No. 1.1, a lens No. 2.2, a lens No. 3.3, a laser light source, a laser filter, a dichroic mirror, a fluorescent filter, a photoelectric sensor, a fiber optic host end, a fiber optic probe end, a probe No. 100, a probe No. 101, a probe lens No. 200, a handle, a fiber optic cable No. 300, a fiber optic protective layer No. 301, a fiber optic 302, a portable host, a L-shaped optical path No. 401, a laser emission unit No. 402, a fluorescence detection unit No. 403, a controller No. 404, a HMI man-machine interface No. 405, a wireless device No. 407, a power supply system No. 408, a battery No. 500 and a power adapter are shown.

Detailed Description

The parathyroid gland detection device based on the L-shaped light path shown in fig. 1 comprises a probe 100, a handle 200, an optical fiber cable 300, a portable host 400 and a power adapter 500.

The top end of the probe 100 is provided with a probe lens 101, which can focus the emitted laser to the tissue to be detected to improve the laser intensity, and can also focus and transmit weak fluorescent signals which are difficult to detect on the side to the optical fiber 302.

The portable host 400 comprises an L-shaped light path 401, a laser emission unit 402, a fluorescence detection unit 403, a controller 404, an HMI (human machine interface) 405, a wireless device 406, a power supply system 407 and a battery 408.

The HMI 405 can be displayed on a display screen, and can also have the presentation forms of sound and light alarm and the like, and various high-efficiency identification display modes are favorable for clinicians to quickly position parathyroid gland.

The optical fiber cable 300 passes through the handle 200, one end of the optical fiber cable is positioned at the focal point of the probe lens 101, and the other end of the optical fiber cable is positioned at the focal point of the No. 2 lens 2.

The power supply system 407 charges the battery 408 while supplying power normally when an external power source is available, and may supply power to the apparatus through the battery 408 when no external power source is available in a special case.

As shown in fig. 2, the optical fiber cable 300 adopts a single optical fiber design, which not only increases the aperture of the optical fiber 302 to improve the fluorescence receiving efficiency, but also receives more fluorescence signals, because the emitting end face and the receiving end face of the single optical fiber are designed to be the same end face, the receiving end face can receive all the vertically reflected fluorescence signals, and because the emitting end face and the receiving end face of the optical fiber are coplanar, they can be located at the focal point of the probe lens 101 at the same time, thereby improving the laser density and enhancing the fluorescence signal intensity, which cannot be realized by adopting a multi-path optical fiber design.

The L-shaped light path shown in fig. 3 is: there are two vertically axes to be X axle and Y axle respectively, on the X axle place be No. 2 lens 2, dichroic mirror 6, fluorescence filter 7, No. 3 lens 3, photoelectric sensor 8 in proper order, on the Y axle place be laser source 4, No. 1 lens 1, laser filter 5, dichroic mirror 6 in proper order, wherein: the laser light source 4 is located at the focal position of the No. 1 lens 1, the photoelectric sensor 8 is located at the focal position of the No. 3 lens 3, the included angle between the laser light filter 5 and the fluorescent light filter 7 is 90 degrees, the dichroic mirror 6 is placed at the intersection position of two axes, is located between the laser light filter 5 and the fluorescent light filter 7 and is 45 degrees with the two light filters, the optical fiber host end 9 is located at the focal position of the No. 2 lens 2, and the optical fiber probe end 10 is located at the focal position of the probe lens 101.

The L-shaped optical path shown in fig. 3 is divided into a laser excitation path and a fluorescence receiving path.

The laser excitation path is as follows:

1. the laser source 4 emits laser, and the laser is collimated by the No. 1 lens 1;

2. the laser filters stray light with other wavelengths through a laser filter 5;

3. after laser is refracted by the dichroic mirror 6 (the dichroic mirror refracts the laser in a laser wave band);

4. laser is focused to the end 9 of the optical fiber host through a No. 2 lens 2;

5. laser light is transmitted by the optical fiber and emitted from the optical fiber probe end 10;

6. the laser focuses the laser on the human tissue to be measured through the probe lens 101.

The fluorescence receiving channel dredging:

1. the excited fluorescence signal is focused to the optical fiber probe end 10 through the probe lens 101;

2. the fluorescence signal is transmitted to the optical fiber host end 9 by the optical fiber and output;

3. the fluorescent signal is collimated through a No. 2 lens 2 fluorescent signal;

4. the fluorescence signal is transmitted by the dichroic mirror 6 (the dichroic mirror transmits the fluorescence signal in the fluorescence band);

5. the fluorescent signal passes through a fluorescent filter 7 to filter stray light with other wavelengths;

6. the fluorescence signal is focused through lens 3 # to the photosensor 8.

As shown in fig. 4, the working principle of the present invention is that an operation instruction is sent to a controller 404 through an HMI human machine interface 405 or a wireless device 406, the controller 404 sends out a modulation signal, a laser light source 16 sends out the modulated laser signal, the modulated laser signal is irradiated to a tissue to be measured such as parathyroid gland through an L-shaped light path 401 by a probe 100, an excited fluorescence signal can send out a similar signal, the signal is transmitted to a photoelectric sensor 8 through the probe 100 through the L-shaped light path 401, the signal is demodulated through a phase-locked amplification technology, a fluorescence intensity analog signal is generated, and finally, the signal is collected and analyzed by the controller 404, and a detection result is sent out through the HMI human machine interface 405 or the wireless device 406.

The phase-locked amplification technology is an anti-interference technology, because an operating lamp or other light rays in a clinical environment easily interfere parathyroid gland identification, in order to improve parathyroid gland identification rate, a laser light source is modulated, fluorescence can emit a modulation signal consistent with the laser light source, a photoelectric sensor receives the modulated fluorescence signal, the modulated fluorescence signal is demodulated by using a phase-locked amplification principle, and finally a fluorescence intensity analog signal is generated.

As shown in FIG. 5, in embodiment 1, the probe 100 is movably connected with the handle 200, the optical fiber cable 300 at the interface between the probe 100 and the handle 200 is directly coupled, and the probe 100 is used as a replaceable consumable.

As shown in FIG. 6, in embodiment 2, the probe 100, the handle 200 and the optical fiber cable 300 are fixedly connected as replaceable consumables, and the end of the optical fiber cable 300 is movably connected with the portable host 400.

The above are only preferred embodiments of the present invention, and it should be noted that the above preferred embodiments should not be considered as limiting the present invention, and the protection scope of the present invention should be subject to the scope defined by the claims; it will be apparent to those skilled in the art that various modifications and adaptations can be made without departing from the spirit and scope of the invention, and should be considered to be within the scope of the invention.

Claims

1. A parathyroid gland detection device based on L-shaped light path comprises a probe (100), a handle (200), an optical fiber cable (300) and a portable host (400), and is characterized in that: the portable host (400) consists of an L-shaped light path (401), a laser emission unit (402), a fluorescence detection unit (403) and a controller (404), wherein the structure of the L-shaped light path (401) is as follows: the X-axis and the Y-axis are respectively vertical to each other, the No. 2 lens (2), the dichroic mirror (6), the fluorescent filter (7), the No. 3 lens (3) and the photoelectric sensor (8) are sequentially arranged on the X-axis, and the laser light source (4), the No. 1 lens (1), the laser filter (5) and the dichroic mirror (6) are sequentially arranged on the Y-axis.

2. The parathyroid gland detecting device based on the L-shaped optical path as claimed in claim 1, wherein: the optical fiber cable (300) is a single optical fiber.

3. The parathyroid gland detecting device based on the L-shaped optical path as claimed in claim 1, wherein: the top end of the probe (100) is provided with a probe lens (101).

4. The parathyroid gland detecting device based on the L-shaped optical path as claimed in claim 1, wherein: the probe (100) is movably connected with the handle (200), and the probe (100) is directly coupled with the optical fiber cable (300) at the joint of the handle (200).

5. The parathyroid gland detecting device based on the L-shaped optical path as claimed in claim 1, wherein: the portable host (400) is internally provided with a battery (408).