CN117815155A - Environment-friendly antibacterial skin-friendly wet tissue and preparation method thereof - Google Patents
Environment-friendly antibacterial skin-friendly wet tissue and preparation method thereof Download PDFInfo
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- CN117815155A CN117815155A CN202410247655.2A CN202410247655A CN117815155A CN 117815155 A CN117815155 A CN 117815155A CN 202410247655 A CN202410247655 A CN 202410247655A CN 117815155 A CN117815155 A CN 117815155A
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Landscapes
- Cosmetics (AREA)
Abstract
The invention discloses an environment-friendly antibacterial skin-friendly wet wipe and a preparation method thereof, and relates to the technical field of wet wipes; the environment-friendly antibacterial skin-friendly wet tissue comprises a skin-friendly fiber type carrier and antibacterial repair liquid medicine; the antibacterial repairing liquid medicine comprises an antibacterial repairing composition and an auxiliary agent; the antibacterial repairing composition comprises an outer layer capsule membrane, an inner layer capsule membrane and a capsule core material, wherein the capsule core material comprises a pulsatilla root saponin enzymolysis product, a hydrolyzed rice extract and a wild soybean sprout extract, the inner layer capsule membrane is a safflower extract, and the outer layer capsule membrane is chondroitin sulfate; the active ingredients of the capsule core material and the inner layer film have the effects of resisting bacteria, inflammation and oxidization, the outer layer capsule film is extremely easy to absorb water to improve the skin moisturizing ability, the inner layer capsule film takes fat-soluble substances as emulsifying agents, the capsule core material can permeate into the skin through the keratinocyte gaps, the components are synergistic, and the effects of moisturizing the skin are achieved while the antibacterial effect is achieved.
Description
Technical Field
The invention belongs to the technical field of wet towel preparation, and particularly relates to an environment-friendly antibacterial skin-friendly wet towel and a preparation method thereof.
Background
The use of wet tissues has become more and more popular in recent years, and becomes a necessary daily product for many families, which has the characteristics of convenience, rapidness, cleanliness and sanitation, is generally used in the fields of baby care, personal hygiene, family cleaning and the like, so that the wet tissues become indispensable products in modern life, and along with the increase of the requirements on cleanliness and sanitation, the preparation materials and methods are also continuously innovated and improved.
The wet tissues currently on the market are generally composed of two parts: the wet tissue carrier and the liquid medicine are characterized in that the wet tissue carrier is usually one of non-woven fabrics, cotton cloth and paper towels, and has the characteristics of softness, fluffiness and high hygroscopicity; the components of the liquid medicine generally comprise water, a humectant, a preservative, an antibacterial agent, a nonionic surfactant and the like, are the most core technology of wet tissues, most of the liquid medicine used in the wet tissues industry at present is chemical components, and usually some powerful chemical bactericides and preservatives are added to improve the antibacterial effect of the wet tissues and prolong the shelf life of the wet tissues, so that the safety of the wet tissues is low, and the effect of the active ingredients of the wet tissues is not obvious; therefore, in order to solve the above problems, it is an urgent need in the art to provide a wet wipe that has an excellent environment-friendly and effective antibacterial function, does not irritate the skin, and can also increase the skin care function.
The prior art mainly has the following problems: 1. the chemical agent in the middle of the wet tissue liquid medicine has irritation to the skin, and can cause injury to the skin after long-term use; 2. the effective components of the chemical agents in the wet tissue liquid medicine are single and the absorption efficiency is common; 3. the active ingredients of the plant extract are easy to lose in the production process of the wet tissue liquid medicine, and the long-term effective stability of the plant extract is difficult to be maintained.
Disclosure of Invention
Aiming at the situation, in order to overcome the defects of the prior art, the invention provides an environment-friendly antibacterial skin-friendly wet tissue, which comprises a skin-friendly fiber type carrier and antibacterial repair liquid medicine.
Preferably, the antibacterial repairing liquid medicine comprises 2-10 parts of antibacterial repairing composition, 40-60 parts of deionized water, 0.05-0.15 part of vitamin C, 0.1-0.2 part of humectant, 1-3 parts of polyalcohol, 0.02-0.1 part of PEG-40 hydrogenated castor oil and 0.6-1 part of pH regulator.
Preferably, the bacteriostatic repair composition consists of an outer capsule membrane, an inner capsule membrane and a capsule core material.
Preferably, the weight ratio of the outer layer capsule membrane to the inner layer capsule membrane to the capsule core material is (0.5-1) (8-10).
Preferably, the skin-friendly fiber type carrier is one of spunlaced non-woven fabrics, cotton cloth and paper towels.
Preferably, the outer envelope is chondroitin sulfate.
Preferably, the inner capsule is safflower extract.
Preferably, the capsule core comprises the following components in parts by weight: 10-20 parts of pulsatilla chinensis saponin enzymolysis products, 20-30 parts of hydrolyzed rice extracts and 30-50 parts of wild soybean sprout extracts.
Preferably, the pulsatilla saponin enzymolysis product is at least one of pulsatilla sapogenin, 1-glycosyl pulsatilla saponin and 2-glycosyl pulsatilla saponin.
Preferably, the humectant is selected from one or more of glycerol, 1, 3-butanediol, propylene glycol, hexylene glycol, and methylpropylene glycol.
Preferably, the polyhydric alcohol comprises one or more of sorbitol, octanediol, dipropylene glycol, methyl propylene glycol, erythritol, maltitol, mannitol, pentanediol, ethylhexyl glycerol, isopentyl glycol, and hexanediol.
Preferably, the pH regulator is at least one selected from glacial acetic acid, citric acid, sodium citrate, sodium hydroxide and potassium hydroxide.
Preferably, the preparation method of the hydrolyzed rice extract specifically comprises the following steps:
adding rice into water according to a weight ratio of 1:10, regulating pH to 7.8, regulating temperature to 55 ℃, adding rice proteolytic enzyme, continuously stirring and hydrolyzing for 10 hours, heating to 85 ℃, inactivating enzyme for 10 minutes, filtering, adding activated carbon into filtrate to decolorize and debitterize, filtering, and drying to obtain hydrolyzed rice extract;
preferably, the weight ratio of rice to rice proteolytic enzyme is 1:0.5-1.5;
preferably, the preparation method of the wild soybean sprout extract specifically comprises the following steps:
squeezing the wild soybean embryo to obtain juice, enriching the juice with macroporous weak acid cation exchange resin, eluting with 85% ethanol water solution to obtain eluate, concentrating under reduced pressure, and drying to obtain wild soybean sprout extract;
preferably, the macroporous weakly acidic cation exchange resin is langerhans CNP80 resin;
preferably, during exchange elution, the flow rate of the regeneration liquid is 6m/h, the regeneration contact time is 40min, the forward washing flow rate is 20m/h, the forward washing time is 25min, and the operation flow rate is 35m/h.
Preferably, the preparation method of the safflower extract specifically comprises the following steps:
adding 80% ethanol water solution into Carthami flos at a weight ratio of 1:30, extracting for 12 hr for 2 times, collecting filtrate, vacuum distilling under reduced pressure to vacuum degree of-0.08 MPa, and drying the distillate to obtain Carthami flos extract.
Preferably, the preparation method of the antibacterial repairing composition comprises the following steps:
s1, mixing a balloon core material pulsatilla saponin enzymolysis product, a hydrolyzed rice extract and a wild soybean sprout extract, adding into a grinder, grinding, and sieving with a 400-600 mesh sieve to obtain balloon core material powder;
s2, adding the safflower extract as an encapsulating material into purified water, stirring the safflower extract solution to dissolve the safflower extract, adding an emulsifier in the weight ratio of the safflower extract solution to the emulsifier (8-10): 1, stirring at 50-60 ℃, keeping the stirring speed, and cooling to room temperature to obtain W/O type inner layer capsule membrane liquid;
s3, adding the encapsulating material chondroitin sulfate into purified water, stirring to dissolve the encapsulating material chondroitin sulfate at 50-60 ℃, keeping the stirring speed, and cooling to room temperature to obtain outer layer capsule membrane liquid;
s4, adding the capsule core material powder obtained in the S1 into the inner layer capsule membrane liquid obtained in the S2, homogenizing to obtain a mixture, preparing the mixture into a single-layer miniature capsule composition by adopting a spray drying method, and cooling to obtain a pretreatment antibacterial repairing composition;
s5, uniformly coating the outer layer capsule solution obtained in the step S3 on the outer surface of the pretreated antibacterial repairing composition by adopting a coating method, drying and cooling to obtain the antibacterial repairing composition;
preferably, in S2, the weight ratio of the encapsulating material safflower extract to the purified water is 1:4;
preferably, in S2, the emulsifier is one or more of cephalin, hydrogenated lecithin, serine phospholipids;
preferably, in S3, the weight ratio of the encapsulating material chondroitin sulfate to the purified water is 1:4;
preferably, in the S4, in the spray drying process, the spray pressure is 0.40-0.45 MPa, the feeding speed is 10-20 mL/min, and the air inlet temperature is 130-150 ℃;
preferably, in S5, during the coating process, the spraying pressure is 0.20-0.35MPa, the feeding speed is 8-15 mL/min, the air inlet temperature is 120-130 ℃, and the coating weight is increased by 0.5-1%.
The invention also provides a preparation method of the environment-friendly antibacterial skin-friendly wet tissue, which comprises the following steps:
cutting and folding the raw material of the fiber type carrier, and sterilizing at high temperature to obtain a skin-friendly fiber type carrier; fully mixing the antibacterial repairing composition, deionized water, vitamin C, humectant, polyalcohol, PEG-40 hydrogenated castor oil and pH regulator, sterilizing and cooling to obtain antibacterial repairing liquid medicine; spraying the antibacterial repairing liquid medicine on a skin-friendly fiber type carrier to obtain the environment-friendly antibacterial skin-friendly wet tissue.
The beneficial effects obtained by the invention are as follows:
according to the invention, the active substances are coated in the double-layer capsule structure, so that the stability of the active ingredients is improved, the penetration capacity of the antibacterial repairing composition on the surface layer and the inner layer of the skin is improved, the absorption effect of the skin substrate on the active substances is improved, the efficient antibacterial effect can be achieved, and the moisturizing repairing effect can be realized on the skin; in the double-layer capsule, chondroitin sulfate is taken as an outer-layer capsule, and is acidic mucopolysaccharide obtained from animal cartilage tissues, so that on one hand, the double-layer capsule is extremely easy to absorb water and strong in water locking capacity, and forms a high-viscosity mucilaginous texture after being dissolved in water, and a layer of breathable water-retaining film can be formed on the surface of skin for a long time, so that the skin moisturizing capacity is improved, and the absorption of the antibacterial repair composition on the surface layer of the skin is increased; on the other hand, the chondroitin sulfate enhances skin permeability, accelerates metabolism, promotes the absorption of the antibacterial repairing composition, is beneficial to relieving skin inflammation and has anti-aging effect; the safflower extract (containing safflower polysaccharide, safflower glycoside, palmitic acid, linoleic acid and the like) is used as an inner layer capsule membrane, the safflower is used for promoting wound healing, softening cutin and enhancing blood circulation, the cephalin is used as an emulsifier of the inner layer capsule membrane, the cephalin has a similar bilayer structure with phospholipid on the surface of human cells, the inner layer of the capsule membrane comprises the safflower extract and the cephalin, the high lipophilicity of the inner layer of the capsule membrane is beneficial to the transmission of the encapsulated capsule core material in the cuticle space, and the safflower extract released through the cell space can soften cutin, so that the antibacterial repairing composition is easier to penetrate through the cuticle under the action of skin hydration; thirdly, the safflower extract released through the cell gap accelerates the blood circulation and the transfer of other substances which remove the outer layer of the capsule membrane, and the interaction of the safflower extract, the other substances and the capsule membrane leads more capsule core substances to enter the muscle base; the safflower extract and the wild soybean sprout extract are rich in flavonoid compounds, on one hand, free radicals can be neutralized, sebum secretion can be effectively reduced, dirt and bacteria in pores can be removed, and itching, pain and swelling of skin can be relieved; on the other hand, the composition can inhibit the growth and propagation of skin bacteria such as staphylococcus aureus, candida albicans, armpit coccus, staphylococcus albicans and the like; the pulsatilla root saponin enzymolysis product in the capsule core material has a promoting effect on the collagen synthesis of the fibroblasts, the hydrolyzed rice extract is rich in amino acids, the fibroblasts can be promoted to produce collagen, the wild soybean sprout extract contains rich flavone components, the growth of the fibroblasts is promoted, the pulsatilla root saponin enzymolysis product, the hydrolyzed rice extract and the wild soybean sprout extract jointly act on the fibroblasts, the active components have strong cooperation and synergistic effect, and skin pathogens can be well inhibited.
Drawings
FIG. 1 is a scanning electron microscope image of the bacteriostatic repair composition according to example 1 of the invention;
FIG. 2 is a graph showing the measurement results of the antibacterial performance of the antibacterial repair liquid medicines in examples 1 to 3 and comparative examples 1 to 4 according to the present invention;
FIG. 3 is a graph showing the measurement results of the moisturizing performance of the environment-friendly antibacterial skin-friendly wet tissues described in examples 1-3 and comparative examples 1-4;
FIG. 4 is a graph showing the results of the oxidation resistance measurement of the environment-friendly antibacterial skin-friendly wet tissues described in examples 1 to 3 and comparative examples 1 to 4.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the attached tables in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments; all other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art. In addition, any methods and materials similar or equivalent to those described herein can be used in the present invention. The preferred methods and materials described herein are illustrative only and should not be construed as limiting the scope of the present application.
The experimental methods in the following examples are all conventional methods unless otherwise specified; the test materials used in the examples described below, unless otherwise specified, were purchased from commercial sources.
Example 1
The embodiment provides an environment-friendly antibacterial skin-friendly wet tissue, which comprises a skin-friendly fiber type carrier and antibacterial repair liquid medicine; the antibacterial repairing liquid medicine comprises 2 parts of antibacterial repairing composition, 40 parts of deionized water, 0.05 part of vitamin C, 0.1 part of glycerol, 1 part of sorbitol, 0.02 part of PEG-40 hydrogenated castor oil and 0.6 part of glacial acetic acid.
The antibacterial repairing composition consists of an outer layer capsule membrane, an inner layer capsule membrane and a capsule core material in a weight ratio of 0.5:0.5:8;
the skin-friendly fiber type carrier is a spunlaced non-woven fabric;
the outer layer capsule membrane is chondroitin sulfate;
the inner layer capsule is flos Carthami extract;
the capsule core material comprises the following components in parts by weight: 1 glycosyl anemonin 10 parts, hydrolyzed rice extract 20 parts, and wild soybean sprout extract 30 parts.
The preparation method of the hydrolyzed rice extract specifically comprises the following steps:
adding 20g of rice into 200g of water, regulating the pH value to 7.8, regulating the temperature to 55 ℃, adding 10g of rice proteolytic enzyme, continuously stirring and hydrolyzing for 10 hours, heating to 85 ℃, inactivating enzyme for 10 minutes, filtering, adding activated carbon into filtrate to decolor and debitterize, filtering, and drying to obtain hydrolyzed rice extract;
the preparation method of the wild soybean sprout extract specifically comprises the following steps:
squeezing 30g of wild soybean germs to obtain juice, enriching the juice with Langsheng CNP80 resin, eluting with an ethanol water solution with the volume fraction ratio of 85%, enabling the flow rate of a regenerated solution to be 6m/h, enabling the regeneration contact time to be 40min, enabling the forward washing flow rate to be 20m/h, enabling the forward washing time to be 25min, enabling the running flow rate to be 35m/h, obtaining an eluent, concentrating under reduced pressure, and drying to obtain the wild soybean sprout extract;
the preparation method of the safflower extract specifically comprises the following steps:
adding 5g of safflower into 80% ethanol water solution, extracting for 12h for 2 times, collecting filtrate, vacuum distilling under reduced pressure to vacuum degree of-0.08 MPa, and drying distillate to obtain safflower extract.
The preparation method of the antibacterial repairing composition comprises the following steps:
s1, mixing 10g of anemonin, 20g of hydrolyzed rice extract and 30g of wild soybean sprout extract, adding into a grinder, grinding, and sieving with a 400-mesh sieve to obtain capsule core material powder;
s2, adding 4g of the encapsulating material into 40g of purified water, stirring to dissolve the encapsulating material, adding 0.5g of cephalin into the stirring, keeping the stirring speed unchanged at 50 ℃, and cooling to room temperature to obtain W/O type inner layer capsule membrane liquid;
s3, adding 4g of the encapsulating material chondroitin sulfate into 40g of purified water, stirring to dissolve the encapsulating material chondroitin sulfate at 50 ℃, keeping the stirring speed unchanged, and cooling to room temperature to obtain outer-layer capsule membrane liquid;
s4, adding the capsule core material powder obtained in the S1 into the inner layer capsule membrane liquid obtained in the S2, homogenizing to obtain a mixture, preparing the mixture into a single-layer miniature capsule composition by adopting a spray drying method, wherein the spray pressure is 0.40MPa, the feeding speed is 10mL/min, the air inlet temperature is 130 ℃, and cooling to obtain the pretreatment antibacterial repairing composition;
s5, uniformly coating the outer layer capsule film solution obtained in the step S3 on the outer surface of the pretreated antibacterial repairing composition by adopting a coating method, spraying at the pressure of 0.20MPa, feeding at the speed of 8mL/min, air inlet at the temperature of 120 ℃, coating weight gain of 0.5%, drying, and cooling to obtain the antibacterial repairing composition.
The invention also provides a preparation method of the environment-friendly antibacterial skin-friendly wet tissue, which comprises the following steps:
cutting and folding the raw material of the fiber type carrier, and sterilizing at high temperature to obtain a skin-friendly fiber type carrier; fully mixing the antibacterial repairing composition, deionized water, vitamin C, glycerol, sorbitol, PEG-40 hydrogenated castor oil and glacial acetic acid, sterilizing and cooling to obtain antibacterial repairing liquid medicine; spraying the antibacterial repairing liquid medicine on a skin-friendly fiber type carrier to obtain the environment-friendly antibacterial skin-friendly wet tissue.
Example 2
The embodiment provides an environment-friendly antibacterial skin-friendly wet tissue, which comprises a skin-friendly fiber type carrier and antibacterial repair liquid medicine; the antibacterial repairing liquid medicine comprises 6 parts of antibacterial repairing composition, 50 parts of deionized water, 0.1 part of vitamin C, 0.15 part of propylene glycol, 2 parts of octaethylene glycol, 0.06 part of PEG-40 hydrogenated castor oil and 0.8 part of citric acid.
The antibacterial repairing composition consists of an outer layer capsule membrane, an inner layer capsule membrane and a capsule core material in a weight ratio of 0.8:0.8:9;
the skin-friendly fiber type carrier is a spunlaced non-woven fabric;
the outer layer capsule membrane is chondroitin sulfate;
the inner layer capsule is flos Carthami extract;
the capsule core material comprises the following components in parts by weight: 15 parts of pulsatilla chinensis sapogenin, 25 parts of hydrolyzed rice extract and 40 parts of wild soybean sprout extract.
The hydrolyzed rice extract was prepared in the same manner as in example 1.
The preparation method of the extract of the wild soybean sprouts was the same as in example 1.
The preparation method of the safflower extract is the same as in example 1.
The preparation method of the antibacterial repairing composition comprises the following steps:
s1, mixing 15g of anemonin, 25g of hydrolyzed rice extract and 40g of wild soybean sprout extract, adding into a grinder, grinding, and sieving with a 500-mesh sieve to obtain capsule core material powder;
s2, adding 7g of the encapsulating material of safflower extract into 70g of purified water, stirring to dissolve the safflower extract, adding 0.875g of cephalin into the mixture, keeping the stirring speed unchanged at 55 ℃, and cooling to room temperature to obtain W/O type inner layer capsule membrane liquid;
s3, adding 7g of the encapsulating material chondroitin sulfate into 70g of purified water, stirring to dissolve the encapsulating material chondroitin sulfate, keeping the stirring speed unchanged at 55 ℃, and cooling to room temperature to obtain outer-layer capsule membrane liquid;
s4, adding the capsule core material powder obtained in the S1 into the inner layer capsule membrane liquid obtained in the S2, homogenizing to obtain a mixture, preparing the mixture into a single-layer miniature capsule composition by adopting a spray drying method, wherein the spray pressure is 0.42MPa, the feeding speed is 15mL/min, the air inlet temperature is 140 ℃, and cooling to obtain the pretreatment antibacterial repairing composition;
s5, uniformly coating the outer layer capsule film solution obtained in the step S3 on the outer surface of the pretreated antibacterial repairing composition by adopting a coating method, spraying at the pressure of 0.28MPa, feeding at the speed of 12mL/min and the air inlet temperature of 125 ℃, coating and weighting by 0.8%, drying, and cooling to obtain the antibacterial repairing composition.
The invention also provides a preparation method of the environment-friendly antibacterial skin-friendly wet tissue, and the specific steps are the same as those of the embodiment 1.
Example 3
The embodiment provides an environment-friendly antibacterial skin-friendly wet tissue, which comprises a skin-friendly fiber type carrier and antibacterial repair liquid medicine; the antibacterial repairing liquid medicine comprises 10 parts of antibacterial repairing composition, 60 parts of deionized water, 0.15 part of vitamin C, 0.2 part of hexanediol, 3 parts of dipropylene glycol, 0.1 part of PEG-40 hydrogenated castor oil and 1 part of citric acid.
The antibacterial repairing composition consists of an outer layer capsule membrane, an inner layer capsule membrane and a capsule core material in a weight ratio of 1:1:10;
the skin-friendly fiber type carrier is a spunlaced non-woven fabric;
the outer layer capsule membrane is chondroitin sulfate;
the inner layer capsule is flos Carthami extract;
the capsule core material comprises the following components in parts by weight: 20 parts of 2-glycosyl anemonin, 30 parts of hydrolyzed rice extract and 50 parts of wild soybean sprout extract.
The hydrolyzed rice extract was prepared in the same manner as in example 1.
The preparation method of the extract of the wild soybean sprouts was the same as in example 1.
The preparation method of the safflower extract is the same as in example 1.
The preparation method of the antibacterial repairing composition comprises the following steps:
s1, mixing 20g of anemonin, 30g of hydrolyzed rice extract and 50g of wild soybean sprout extract, adding into a grinder, grinding, and sieving with a 600-mesh sieve to obtain capsule core material powder;
s2, adding 10g of the encapsulating material of safflower extract into 100g of purified water, stirring to dissolve the safflower extract, adding 1g of cephalin into the mixture, keeping the stirring speed unchanged at 60 ℃, and cooling to room temperature to obtain W/O type inner layer capsule membrane liquid;
s3, adding 10g of the encapsulating material chondroitin sulfate into 100g of purified water, stirring to dissolve the encapsulating material, keeping the stirring speed unchanged at 60 ℃, and cooling to room temperature to obtain outer layer capsule membrane liquid;
s4, adding the capsule core material powder obtained in the S1 into the inner layer capsule membrane liquid obtained in the S2, homogenizing to obtain a mixture, preparing the mixture into a single-layer miniature capsule composition by adopting a spray drying method, wherein the spray pressure is 0.45MPa, the feeding speed is 20mL/min, the air inlet temperature is 150 ℃, and cooling to obtain the pretreatment antibacterial repairing composition;
s5, uniformly coating the outer layer capsule film solution obtained in the step S3 on the outer surface of the pretreated antibacterial repairing composition by adopting a coating method, spraying at the pressure of 0.35MPa, feeding at the speed of 15mL/min and the air inlet temperature of 130 ℃, coating and weighting by 1%, drying, and cooling to obtain the antibacterial repairing composition.
The invention also provides a preparation method of the environment-friendly antibacterial skin-friendly wet tissue, and the specific steps are the same as those of the embodiment 1.
Comparative example 1
This comparative example provides an environment-friendly bacteriostatic skin-friendly wet wipe which is different from example 1 only in that hydrolyzed rice extract and wild soybean sprout extract are not included in the center of the capsule; the enzymolysis product of the pulsatilla chinensis saponin is 2-glycosyl pulsatilla chinensis saponin, the preparation method of the safflower extract is the same as that of example 1, and the preparation methods of the antibacterial repairing composition and the environment-friendly antibacterial skin-friendly wet tissue are the same as that of example 1.
Comparative example 2
This comparative example provides an environmentally friendly bacteriostatic skin-friendly wet wipe which differs from example 1 only in that it does not include an outer capsular membrane; the pulsatilla chinensis saponin enzymolysis product is 2-glycosyl pulsatilla chinensis saponin, the preparation method of the hydrolyzed rice extract is the same as that of example 1, the preparation method of the wild soybean sprout extract is the same as that of example 1, the preparation method of the antibacterial repairing composition does not comprise steps S3 and S5, and the preparation method of the environment-friendly antibacterial skin-friendly wet tissue is the same as that of example 1.
Comparative example 3
This comparative example provides an environmentally friendly bacteriostatic skin-friendly wet wipe which differs from example 1 only in that it does not include an inner capsular membrane; the pulsatilla chinensis saponin enzymolysis product is 2-glycosyl pulsatilla chinensis saponin, the preparation method of the hydrolyzed rice extract is the same as that of example 1, the preparation method of the wild soybean sprout extract is the same as that of example 1, the preparation method of the antibacterial repairing composition does not comprise steps S2 and S4, and the preparation method of the environment-friendly antibacterial skin-friendly wet tissue is the same as that of example 1.
Comparative example 4
This comparative example provides an environmentally friendly bacteriostatic skin-friendly wet wipe which differs from example 1 only in that it does not include an inner and outer capsular membrane; the pulsatilla chinensis saponin enzymolysis product is 2-glycosyl pulsatilla chinensis saponin, the preparation method of the hydrolyzed rice extract is the same as that of example 1, the preparation method of the wild soybean sprout extract is the same as that of example 1, the preparation method of the antibacterial repairing composition does not comprise steps S2-S5, and the preparation method of the environment-friendly antibacterial skin-friendly wet tissue is the same as that of example 1.
Experimental example 1
In this experimental example, a scanning electron microscope was used to observe the microscopic morphology of the bacteriostatic repair composition prepared in example 1, and fig. 1 is an SEM image of the bacteriostatic repair composition prepared in example 1, as shown in the figure, the bacteriostatic repair composition prepared in this example is a double-layer film covering structure, and a hydrophilic outer layer film covers an inner layer film and a capsule core.
Experimental example 2
The antibacterial performance of the antibacterial repair liquid medicine described in the examples 1-3 and the comparative examples 1-4 is measured in the experimental example, and the specific method is as follows: pipette 5mL of the solution at a concentration of 10 5 CFU/mL of Staphylococcus aureus suspension was dropped into examples 1-3 and respectively2mL of the antibacterial repairing liquid medicine obtained in comparative examples 1-3 is taken as an experimental group, 2mL of physiological saline is dripped into the experimental group as a control blank group, a nutrient agar culture medium is introduced, a sterile triangular bar is used for coating uniformly, ventilation drying is carried out for 15min, a sterile filter paper sheet with the diameter of about 5mm is placed in the center of a flat plate culture medium, the culture is carried out at 37 ℃ for 24h and 7d respectively, the colony count is measured according to a flat plate counting method, 3 groups of parallel experiments are carried out on each sample, the counting result is averaged, and the antibacterial rate of the skin care composition is calculated according to the following formula:
；
FIG. 2 is a graph showing the measurement results of the antibacterial performance of the antibacterial repair liquid medicines in examples 1-3 and comparative examples 1-4, wherein the antibacterial ratio of the antibacterial repair liquid medicine in examples 1-3 to golden yellow wine bacteria only reaches 49.8-53.4% in the first 24 hours, the antibacterial ratio of the antibacterial repair liquid medicine in golden yellow wine bacteria after 7d reaches 98.6-100%, the antibacterial ratio of the antibacterial repair liquid medicine in comparative example 1 to golden yellow wine bacteria only reaches 65.3% in the first 24 hours, the antibacterial ratio of the antibacterial repair liquid medicine in comparative example 1 to golden yellow wine bacteria only reaches 45.3%, the antibacterial ratio of the antibacterial repair liquid medicine in comparative example 2 to golden yellow wine bacteria only reaches 75.6% in the first 24 hours, the antibacterial ratio of the antibacterial repair liquid medicine in comparative example 3 to golden yellow wine bacteria only reaches 54.1%, the antibacterial ratio of the antibacterial repair liquid medicine in the first 24 hours to golden yellow wine bacteria only reaches 68.2%, the antibacterial ratio of the antibacterial repair liquid medicine in comparative example 3 to golden yellow wine bacteria only reaches 46.2%, the antibacterial ratio of the antibacterial repair liquid medicine in the first 24 hours to golden yellow wine bacteria only reaches 78.5% in the antibacterial ratio of the antibacterial repair liquid medicine after 7 d; the antibacterial repairing composition described in examples 1-3 coats the active substances in a double-layer capsule structure, so that the stability of the active ingredients is improved, the antibacterial repairing composition can not be completely absorbed only when the antibacterial repairing composition is used for 24 hours, the antibacterial active substances can not exert a high-efficiency antibacterial effect in a short time, and after 7 days, the antibacterial repairing composition slowly releases the antibacterial active substances, and the stability of the antibacterial repairing composition is maintained for a long time, so that the antibacterial rate on staphylococcus aureus can be effectively improved; the bacteriostatic repair composition of comparative example 1 does not include hydrolyzed rice extract and wild soybean sprout extract, and the active ingredient in the capsule core is reduced, resulting in lower bacteriostatic rate; the antibacterial repair composition of comparative example 2 does not include an outer envelope, the active ingredient is not coated by double films, and the stability is reduced, so that the antibacterial rate is reduced; the antibacterial repair composition of comparative example 3 does not comprise an inner layer capsule membrane, so that after the outer layer capsule membrane enters the stratum corneum, the lipophilic substance is lack of connection and transportation, and the activity of the capsule core substance on staphylococcus aureus through a horny gap is reduced, so that the antibacterial rate is lower; the antibacterial repair composition of comparative example 4 does not include an inner capsule and an outer capsule, only contains a capsule core substance, and the active substance of the capsule core is in direct contact with staphylococcus aureus in the first 24 hours, so that the antibacterial rate can be improved, and the active substance in the plant extract can quickly inhibit the growth and reproduction of the staphylococcus aureus, but the antibacterial repair composition does not have a double-film coated active substance, so that the stability is weak, the content of the antibacterial active substance is gradually reduced after 7 days, and the antibacterial effect on pathogenic bacteria is reduced.
Experimental example 3
The experimental example is used for measuring the moisturizing performance of the environment-friendly antibacterial skin-friendly wet tissues in examples 1-3 and comparative examples 1-4, and the specific method is as follows: the environment-friendly antibacterial skin-friendly wet tissues of examples 1-3 and comparative examples 1-4 were used by 70 subjects, the ages of the subjects were 18-50 years, the male and female proportions were the same, the subjects were divided into 7 groups of 10 persons each, and the same wet tissue was used by each group of subjects; the subject draws a fixed area of 2 square centimeters on the back of the hand in an indoor environment with the temperature of 20 ℃ and the relative humidity of 50%, tests the moisture content of each test part by a Corneometer CM285 skin moisture detector within 1min before use and 1h after use respectively, comprehensively obtains skin moisture change data, and calculates the moisturizing rate and the moisturizing rate according to the following formulas: moisturizing rate (%) = post-use humidity value/pre-use humidity value x 100%; moisture retention (%) =humidity value after 1 hour of use/humidity value after use×100%.
Wherein the humidity value before use, the humidity value after use and the humidity value after use for 1 hour are all average values of each group of subjects.
Table 1 skin moisture values for different time periods
FIG. 3 is a graph showing the measurement results of the moisturizing performance of the environment-friendly antibacterial skin-friendly wet tissues described in examples 1-3 and comparative examples 1-4, wherein the moisturizing rate and the moisturizing rate of the examples 1-3 are obviously higher than those of the comparative examples 1-4, the moisturizing rate of the examples 1-3 reaches 174.80-177.51%, the moisturizing rate reaches 89.6-90.3%, the moisturizing rate of the comparative examples 1-4 only reaches 128.03-150.54%, and the moisturizing rate is only 65.74-78.48%; the environment-friendly antibacterial skin-friendly wet tissue antibacterial repair composition of the comparative example 1 does not comprise hydrolyzed rice extract and wild soybean sprout extract, has few active ingredients in the capsule core material, has affected moisturizing effect after entering skin, and has lower skin moisturizing rate and moisturizing rate; the environment-friendly antibacterial skin-friendly wet tissue antibacterial repair composition of the comparative example 2 does not comprise an outer layer capsule film, and the lipophilic inner layer capsule film reduces the absorption on the surface layer of the skin, so that less capsule core materials enter the muscle sole, and no cartilage sulfate can not form a water-retaining film, thereby influencing the water-supplementing rate and the water-retaining rate; the environment-friendly antibacterial skin-friendly wet tissue antibacterial repair composition of the comparative example 3 does not comprise an inner layer capsule membrane, so that after the outer layer capsule membrane enters a stratum corneum, the lipophilic substance is lack of connection and transportation, and the activity of the capsule core substance entering the muscle sole through a stratum corneum gap is reduced, so that the moisturizing rate and the moisturizing rate are lower; the environment-friendly antibacterial skin-friendly wet tissue antibacterial repair composition of the comparative example 4 does not comprise an inner layer capsule membrane and an outer layer capsule membrane, and the capsule core material cannot better penetrate through a hydrophilic stratum corneum and cannot be transmitted in a lipophilic keratinocyte gap, and cannot deeply contact with skin, so that the skin moisturizing rate and the skin moisturizing rate are greatly reduced.
Experimental example 4
The experimental example is used for measuring the oxidation resistance of the environment-friendly antibacterial skin-friendly wet tissues described in the examples 1-3 and the comparative examples 1-4, and the specific method is as follows: the environment-friendly antibacterial skin-friendly wet tissues prepared in examples 1-3 and comparative examples 1-4 were respectively soaked in a container filled with 500mL of distilled water, the wet tissues were taken out after 1 hour, the water in the wet tissues was squeezed out and stirred uniformly in the container, and the DPPH free radical removal rate and the ABTS+ free radical removal rate of the liquid were measured by a spectrophotometry and represent the DPPH free radical removal rate and the ABTS+ free radical removal rate of the wet tissues prepared in examples 1-3 and comparative examples 1-4.
FIG. 4 is a graph showing the results of the antioxidant performance measurement of the environment-friendly antibacterial skin-friendly wet tissues described in examples 1-3 and comparative examples 1-4, wherein the radical clearance rate of the examples 1-3 is obviously higher than that of the comparative examples 1-4, the radical clearance rate of the examples 1-3 is 95.2-98.6%, the radical clearance rate of the examples 1-3 is 95.3-97.8%, the radical clearance rate of the comparative examples 1-4 is only 45.3-77.3%, and the radical clearance rate of the comparative examples 1-4 is only 48.6-75.2%; the capsule core active substance is composed of a pulsatilla saponin enzymolysis product, a hydrolyzed rice extract and a wild soybean sprout extract, the inner capsule membrane is composed of a safflower extract, the outer capsule membrane is composed of chondroitin sulfate, the active substance is coated in a double-layer capsule membrane structure, the stability of the active ingredient is improved, and the components are synergistic to play a role in high-efficiency oxidation resistance.
Experimental example 5
The experimental example is used for measuring skin irritation of the environment-friendly antibacterial skin-friendly wet tissues described in the examples 1-3 and the comparative examples 1-4, and the specific method is as follows: 70 volunteers aged 18-50 years were randomly divided into 7 groups, 10 persons per group, and the same ratio of men and women, and skin multiple reactions were measured by using the environment-friendly antibacterial skin-friendly wet tissues described in examples 1-3 and comparative examples 1-4, and at 4 observation time points of 1h, 12h, 24h, 48h, and the results are shown in the following table 2:
TABLE 2 results of irritation test on human skin
From the table contents, the measurement results are negative, which indicates that the environment-friendly antibacterial skin-friendly wet tissue disclosed by the invention has no irritation to human skin.
The experimental results show that the environment-friendly antibacterial skin-friendly wet tissue disclosed by the embodiment 1-3 is obviously superior to the samples of the comparative examples 1-4 in all performances, namely, the antibacterial repair composition which contains various active substances (pulsatilla saponin enzymolysis products, hydrolyzed rice extracts and wild soybean sprout extracts) and is wrapped by double-layer capsule has more obvious effects, and three active substances which promote regeneration of fiber bud cells penetrate into skin through keratinocyte gaps under the wrapping action of the double-layer capsule, so that the antibacterial, moisturizing and antioxidant effects are exerted.
Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made therein without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
The invention and its embodiments have been described above with no limitation, and the invention is illustrated in the figures of the accompanying drawings as one of its embodiments, without limitation in practice. In summary, those skilled in the art, having benefit of this disclosure, will appreciate that the invention can be practiced without the specific details disclosed herein.
Claims (9)
1. An environment-friendly antibacterial skin-friendly wet wipe is characterized in that: the environment-friendly antibacterial skin-friendly wet tissue comprises a skin-friendly fiber type carrier and antibacterial repair liquid medicine; the antibacterial repair liquid medicine comprises 2-10 parts of antibacterial repair composition, 40-60 parts of deionized water, 0.05-0.15 part of vitamin C, 0.1-0.2 part of humectant, 1-3 parts of polyalcohol, 0.02-0.1 part of PEG-40 hydrogenated castor oil and 0.6-1 part of pH regulator;
the antibacterial repairing composition consists of an outer layer capsule membrane, an inner layer capsule membrane and a capsule core material in a weight ratio of 0.5-1:0.5-1:8-10;
the capsule core material comprises the following components in parts by weight: 10-20 parts of pulsatilla chinensis saponin enzymolysis products; 20-30 parts of hydrolyzed rice extract; 30-50 parts of wild soybean sprout extract;
the inner layer capsule is flos Carthami extract; the outer layer capsule membrane is chondroitin sulfate.
2. An environmentally friendly bacteriostatic skin-friendly wet wipe according to claim 1, which is characterized in that: the humectant is one or more selected from glycerol, 1, 3-butanediol, propylene glycol, hexylene glycol and methyl propylene glycol; the polyalcohol comprises one or more of sorbitol, octanediol, dipropylene glycol, methyl propylene glycol, erythritol, maltitol, mannitol, pentanediol, ethylhexyl glycerol, isopentyl glycol and hexanediol; the pH regulator is at least one selected from glacial acetic acid, citric acid, sodium citrate, sodium hydroxide and potassium hydroxide.
3. An environmentally friendly bacteriostatic skin-friendly wet wipe according to claim 1, which is characterized in that: the preparation method of the antibacterial repairing composition specifically comprises the following steps:
s1, mixing a balloon core material pulsatilla saponin enzymolysis product, a hydrolyzed rice extract and a wild soybean sprout extract, adding into a grinder, grinding, and sieving with a 400-600 mesh sieve to obtain balloon core material powder;
s2, adding the safflower extract serving as an encapsulating material into purified water, stirring the safflower extract solution to dissolve the safflower extract, adding an emulsifier in the weight ratio (8-10) of the safflower extract solution to the emulsifier (1), stirring at 50-60 ℃, keeping the stirring speed, and cooling to room temperature to obtain W/O type inner layer capsule membrane liquid;
s3, adding the encapsulating material chondroitin sulfate into the purified water, stirring to dissolve the encapsulating material chondroitin sulfate and the purified water at a weight ratio of 1:4 and a temperature of 50-60 ℃, keeping a stirring speed, and cooling to room temperature to obtain an outer layer capsule membrane liquid;
s4, adding the capsule core material powder obtained in the S1 into the inner layer capsule membrane liquid obtained in the S2, homogenizing to obtain a mixture, preparing the mixture into a single-layer miniature capsule composition by adopting a spray drying method, and cooling to obtain a pretreatment antibacterial repairing composition;
and S5, uniformly coating the outer layer capsule solution obtained in the step S3 on the outer surface of the pretreated antibacterial repairing composition by adopting a coating method, drying and cooling to obtain the antibacterial repairing composition.
4. An environmentally friendly bacteriostatic skin-friendly wet wipe according to claim 3, which is characterized in that: in S2, the emulsifier is one or more of cephalin, hydrogenated lecithin and serine phosphatide; in the S4, in the spray drying process, the spray pressure is 0.40-0.45 MPa, the feeding speed is 10-20 mL/min, and the air inlet temperature is 130-150 ℃.
5. An environmentally friendly bacteriostatic skin-friendly wet wipe according to claim 3, which is characterized in that: in S5, in the coating process, the spraying pressure is 0.20-0.35MPa, the feeding speed is 8-15 mL/min, the air inlet temperature is 120-130 ℃, and the coating weight is increased by 0.5-1%.
6. An environmentally friendly bacteriostatic skin-friendly wet wipe according to claim 5, which is characterized in that: the preparation method of the hydrolyzed rice extract comprises the steps of adding rice into water according to a weight ratio of 1:10, adjusting the pH value to 7.8, adjusting the temperature to 55 ℃, adding rice proteolytic enzyme, continuously stirring and hydrolyzing for 10 hours, heating to 85 ℃, inactivating enzyme for 10 minutes, filtering, adding active carbon into filtrate to decolor and debitterize, filtering, and drying to obtain the hydrolyzed rice extract.
7. An environmentally friendly bacteriostatic skin-friendly wet wipe according to claim 6, which is characterized in that: the preparation method of the wild soybean sprout extract comprises squeezing wild soybean embryo to obtain juice, enriching the juice with Langsheng CNP80 resin, eluting with 85% ethanol water solution with volume fraction ratio, and performing exchange elution at a regeneration liquid flow rate of 6m/h and a regeneration contact time of 40min, forward washing flow rate of 20m/h and forward washing time of 25min and an operation flow rate of 35m/h to obtain eluate, concentrating under reduced pressure, and drying to obtain the wild soybean sprout extract.
8. An environmentally friendly bacteriostatic skin-friendly wet wipe according to claim 7, which is characterized in that: the preparation method of the safflower extract comprises the steps of adding 80% ethanol water solution into safflower according to a weight ratio of 1:30, extracting for 12h, extracting for 2 times, collecting filtrate, distilling under reduced pressure, wherein the vacuum degree is-0.08 MPa, and drying the distillate to obtain the safflower extract.
9. A method for preparing the environment-friendly antibacterial skin-friendly wet tissue according to any one of claims 1 to 8, which is characterized in that: the method specifically comprises the following steps: cutting and folding the raw material of the fiber type carrier, and sterilizing at high temperature to obtain a skin-friendly fiber type carrier; fully mixing the antibacterial repairing composition, deionized water, vitamin C, humectant, polyalcohol, PEG-40 hydrogenated castor oil and pH regulator, sterilizing and cooling to obtain antibacterial repairing liquid medicine; spraying the antibacterial repairing liquid medicine on a skin-friendly fiber type carrier to obtain the environment-friendly antibacterial skin-friendly wet tissue.
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| CN1689552A (en) * | 2004-04-19 | 2005-11-02 | 日本日光化学株式会社 | Skin ageing resisting cosmetics and its production method |
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| US20130017239A1 (en) * | 2010-03-24 | 2013-01-17 | Lipotec S.A. | Lipid nanoparticle capsules |
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