CN117598921A - 一种复配型化妆品防腐剂及其制备方法和应用 - Google Patents
一种复配型化妆品防腐剂及其制备方法和应用 Download PDFInfo
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/524—Preservatives
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
本发明公开了一种复配型化妆品防腐剂及其制备方法和应用,包含以下组分:a.山梨坦辛酸酯;b.氯苯甘醚、吡罗克酮乙醇胺盐、二氯苯甲醇、对羟基苯乙酮,对茴香酸、山梨酸、辛酰羟肟酸任选其中一种或多种;c.丙二醇、戊二醇、己二醇、辛二醇至少一种或多种。本发明提出的多种防腐剂复配物在较常规加量更低的条件下较其中一种单一成分防腐效果更佳,由于不含有刺激性成分,安全可靠,用量较少成本低,适合应用于各类化妆品配方中。
Description
技术领域
本发明涉及化妆品防腐技术领域,具体为一种复配型化妆品防腐剂及其制备方法和应用。
背景技术
随着社会水平的发展,人们生活水平的提高,化妆品工业使用的天然原料和各种功能性添加剂日趋增多,为了保证化妆品的安全性和防腐性,多选择在化妆品中添加防腐剂。
经检索,在公开号为CN107496184A一种广谱型化妆品防腐剂及其制备方法和应用中,该发明公开了一种广谱型化妆品防腐剂及其制备方法和应用,该广谱型化妆品防腐剂由苯氧乙醇、苯甲酸、脱氢醋酸和溶剂组成;其中,苯氧乙醇、苯甲酸、脱氢醋酸和溶剂的重量比为20-30:25-35:40-50:65-75,该化妆品防腐剂多选择使用苯氧乙醇、苯甲酸、脱氢醋酸和溶剂实现抗菌且对皮肤温和的护肤作用;
经检索,在公开号为CN110302115A的一种新型能量调理膏中,该发明公开了一种新型能量调理膏,其原料按质量百分比如下:水30-40%,丙二醇10-15%,甘油10-15%,棕榈酸乙基己酯1-3%,棕榈酸异丙酯1-3%,环五聚二甲基硅氧烷1-3%,丙烯酸羟乙酯/丙烯酰二甲基牛磺酸钠共聚物1-3%,聚二甲基硅氧烷1-3%,PEG-40氢化蓖麻油1-3%,薄荷脑5-7%,药用大黄根粉1-3%,皮肤调理剂5-7%,姜根油1-3%,防腐剂3-5%,尿囊素1-3%,EDTA二钠1-3%,黄原胶1-2%,增稠剂1-3%,香兰基丁基醚1-3%,焦糖色0.015%,CI19140:0.0018%,CI 16255:0.0003%,该调理膏添加以及组份较多,导致制备成本增加;
经检索,在公开号为CN110840767A的一种防腐剂组合物及其制备方法和应用中,该发明涉及防腐剂领域,特别涉及一种防腐剂组合物及其制备方法和应用;上述防腐剂组合物包含以下组分,或由以下组分组成:a月桂酰精氨酸乙酯盐酸盐;b苯氧乙醇、氯苯甘油醚、辛酰羟肟酸、对羟基苯乙酮,辛酰基甘氨酸、辛酸甘油酯、乙基己基甘油任选其中一种或多种;c具有C3-C8的二元醇至少一种,上述三个组分在45-75℃条件下搅拌均匀得到,上述防腐剂组合物可应用在化妆品配方中,本发明提供的防腐剂组合物在较低用量下防腐效果优于单一使用月桂酰精氨酸乙酯盐酸盐,由于防腐剂安全性强、不具有刺激性,用量减少成本可控,适合添加于于各种化妆品配方中。
上述专利中所提出的防腐剂组合物多含有苯氧乙醇、苯甲酸或氯苯甘油醚,此类成分已被证明对于敏感性肌肤存在不同程度的刺激作用,若使用量不当易发生刺痛、烧灼等不良反应,此外。如果添加组份较多,易导致制备成本增加,使得防腐剂应用成本过高。
为了开发出刺激性更低、更安全,且成本可控的产品,综上所述的问题,我们提出一种复配型化妆品防腐剂及其制备方法和应用。
发明内容
本发明的目的在于提供一种复配型化妆品防腐剂及其制备方法和应用,解决了现有的问题。
为实现上述目的,本发明提出如下技术方案:一种复配型化妆品防腐剂,包含以下组分:
a.山梨坦辛酸酯;
b.氯苯甘醚、吡罗克酮乙醇胺盐、二氯苯甲醇、对羟基苯乙酮,对茴香酸、山梨酸、辛酰羟肟酸任选其中一种或多种;
c.丙二醇、戊二醇、己二醇、辛二醇至少一种或多种。
优选的,所述b组分选自丙二醇、1,3-丙二醇、戊二醇、1,3-戊二醇、己二醇或辛二醇中的至少一种或多种。
优选的,按照重量百分比计包括:10-35%的a组分、20-60%的b组分、15-75%的c组分。
优选的,所述b组分中按照重量百分比计算:氯苯甘醚为10-20%、吡罗克酮乙醇胺盐10-20%、二氯苯甲醇为10-20%、对羟基苯乙酮10-20%、对茴香酸5-10%、山梨酸5-10%、辛酰羟肟酸10-20%。
一种复配型化妆品防腐剂的制备方法,包括以下步骤:
将所述山梨坦辛酸酯、b组分任意一种或多种和所述c组分任意一种在40-65℃条件下搅拌均匀,得到复配防腐剂。
一种复配型化妆品防腐剂在化妆品中的应用。
一种化妆品,所述化妆品内含有防腐物质,所述防腐物质包括上述防腐组合物。
优选的,所述化妆品中所述含所述防腐剂组合物的用量为0.2-1.8wt%。
优选的,所述化妆品中所述防腐剂组合物的用量为0.2-0.6wt%。
与现有技术相比,本发明的有益效果如下:
本发明提出的多种防腐剂复配物比较同类其他配方,在较低的添加量条件下,刺激性更低、防腐效果优于单一使用其中一种成分,通过优化防腐剂组合使得成本可控,更适合应用于各类化妆品配方中。
具体实施方式
下面对本发明实施例中的技术方案进行清楚、完整地描述,显然,所描述的实施例仅仅是本发明一部分实施例,而不是全部的实施例。
实施案例1:
按照重量百分数计,准备5%的山梨坦辛酸酯、15%的b组分、80%的1,2丙二醇;所述b组分中按照重量百分比计算:氯苯甘醚为10%、吡罗克酮乙醇胺盐10%、二氯苯甲醇为20%、对羟基苯乙酮20%、对茴香酸10%、山梨酸10%、辛酰羟肟酸20%。
将山梨坦辛酸酯、b组分和丙二醇置于在45℃条件下搅拌,至完全溶解,降至室温,最终制得含山梨坦辛酸酯的多种防腐剂复配物。
实施案例2:
按照重量百分数计,准备20%的山梨坦辛酸酯、60%的b组分、20%的1,3丙二醇;所述b组分中按照重量百分比计算:氯苯甘醚为20%、吡罗克酮乙醇胺盐20%、二氯苯甲醇为20%、对羟基苯乙酮20%、对茴香酸5%、山梨酸5%、辛酰羟肟酸10%。
将山梨坦辛酸酯、b组分和1,3丙二醇置于在75℃条件下搅拌,至完全溶解,降至室温,最终制得含山梨坦辛酸酯的多种防腐剂复配物。
实施案例3:
按照重量百分数计,准备10%的山梨坦辛酸酯、40%的b组分、50%的戊二醇;所述b组分中按照重量百分比计算:氯苯甘醚为20%、吡罗克酮乙醇胺盐20%、二氯苯甲醇为10%、对羟基苯乙酮10%、对茴香酸10%、山梨酸10%、辛酰羟肟酸20%。
将山梨坦辛酸酯、b组分和戊二醇置于在60℃条件下搅拌,至完全溶解,降至室温,最终制得含山梨坦辛酸酯的多种防腐剂复配物。
实施案例4:
按照重量百分数计,准备10%的山梨坦辛酸酯、40%的b组分、50%的丙二醇;所述b组分中按照重量百分比计算:氯苯甘醚为20%、吡罗克酮乙醇胺盐20%、二氯苯甲醇为10%、对羟基苯乙酮10%、对茴香酸10%、山梨酸10%、辛酰羟肟酸20%。将山梨坦辛酸酯、b组分置于在60℃条件下搅拌,至完全溶解,降至室温,最终制得含山梨坦辛酸酯的多种防腐剂复配物。
实施案例5:
按照重量百分数计,准备10%的山梨坦辛酸酯、40%的b组分、50%的己二醇;所述b组分中按照重量百分比计算:氯苯甘醚为20%、吡罗克酮乙醇胺盐20%、二氯苯甲醇为10%、对羟基苯乙酮10%、对茴香酸10%、山梨酸10%、辛酰羟肟酸20%。将山梨坦辛酸酯、b组分置于在60℃条件下搅拌,至完全溶解,降至室温,最终制得含山梨坦辛酸酯的多种防腐剂复配物。
实施案例6:
按照重量百分数计,准备10%的山梨坦辛酸酯、40%的b组分、50%的辛二醇;所述b组分中按照重量百分比计算:氯苯甘醚为20%、吡罗克酮乙醇胺盐20%、二氯苯甲醇为10%、对羟基苯乙酮10%、对茴香酸10%、山梨酸10%、辛酰羟肟酸20%。将山梨坦辛酸酯、b组分置于在60℃条件下搅拌,至完全溶解,降至室温,最终制得含山梨坦辛酸酯的多种防腐剂复配物。
实施案例7:
按照重量百分数计,准备10%的山梨坦辛酸酯、60%的b组分、30%的辛二醇;所述b组分中按照重量百分比计算:氯苯甘醚为20%、吡罗克酮乙醇胺盐20%、二氯苯甲醇为10%、对羟基苯乙酮10%、对茴香酸10%、山梨酸10%、辛酰羟肟酸20%。将山梨坦辛酸酯、b组分置于在60℃条件下搅拌,至完全溶解,降至室温,最终制得含山梨坦辛酸酯的多种防腐剂复配物。
对比案例1:
按照重量百分数计,准备20%的山梨坦辛酸酯、80%的己二醇;将山梨坦辛酸酯、辛二醇置于在45℃条件下搅拌,至完全溶解,降至室温,最终制得含山梨坦辛酸酯的多种防腐剂复配物。
实际应用案例1:
将实施例1-7及对比例1制得的多种防腐剂复配物应用于膏霜化妆品中,配方如表1所示:
该膏霜化妆品的制备工艺如下:
步骤1、将A相各组分加至油相锅,加热至75℃,搅拌25分钟以上至完全溶解;
步骤2、将B相各组分加至水相锅,加热至75℃,搅拌25分钟以上,让U20完全溶胀,并均质5分钟;
步骤3、将B相泵入至乳化锅,再将A相慢慢泵入至乳化锅,边泵入边搅拌,直至A相完全泵入到乳化锅,均质10分钟;
步骤4、乳化锅搅拌25分钟后,开始降温,降温至50-55℃,加入C相,均质3分钟;
步骤5、加入D相组分,均质2分钟;
步骤6、降温至40℃,加热E相并均质3分钟;
步骤7、继续搅拌降温至成膏即完成。
空白的膏霜化妆品的配方、制备方法和应用例1类似,不同之处在于,膏霜不添加E。
表1:
对比的膏霜化妆品的配方、制备方法和应用例1类似,不同之处在于,膏霜E成分替换为对比例1制得的防腐剂。
上述膏霜化妆品进行防腐实验:
将上述的膏霜平均分成9份,一份空白乳膏不添加任何防腐剂,对比例制得的多种防腐剂复配物加入1份空白膏霜里,然后把上述复配的实施例1-7的多种防腐剂复配物对应加入另7份空白膏霜里(编号对应),在上述9份膏霜样品中分别加入如下细菌及霉菌:金黄色葡萄球菌(ATCC 6538)、铜绿假单胞菌ATCC9027、黑曲霉ATCCl6404、大肠埃希氏菌ATCC25922、白假丝酵母菌ATCCl0231,接初始种菌量为6.0×106CFU/g或3.0×106CFU/g。
将上述9份加菌的膏霜样品在相同的条件下培养28天,每隔7天进行含菌量检测,结果如表2所示:
表2
从表2可看出采用实施例1-7制得的多种防腐剂复配物作为E成分制备得到的化妆品膏霜剂在7天内即可将细菌和真菌数量降低至小于10cfu/ml,而对比例1制得的防腐剂作为E成分制备得到的化妆品膏霜剂在7天内无法将细菌和真菌数量降低至小于10cfu/ml,需要14天才能将细菌和真菌数量降低至小于10cfu/ml,在实施例1的E组分中的多种防腐剂复配物添加量和对比例1的E组分中的防腐剂添加量相同,均占E组分总量的50%,在膏霜化妆品的总配方中,实施例7和对比例1中的E组分所占的百分比均为0.2%,即实施例1与对比例1所添加的防腐剂总量相同,但防腐效果上,实施例1优于对比例1,即说明了本发明所采用防腐剂组合物在较常规加量更低的条件下,防腐效果优于单一使用月桂酰精氨酸乙酯盐酸盐。
综上所述,本发明提出的多种防腐剂复配物在较常规加量更低的条件下防腐效果优于单一使用一种成分,由于不含有刺激性成分,安全可靠,用量较少成本低,适合应用于各类化妆品配方中。
以上所述仅为本发明的实施例,并非因此限制本发明的专利范围,凡是利用本发明说明书内容所作的等同变换,或直接或间接运用在相关的技术领域,均同理包括在本发明的专利保护范围内。
Claims (9)
1.一种复配型化妆品防腐剂,其特征在于,包含以下组分:
a.山梨坦辛酸酯;
b.氯苯甘醚、吡罗克酮乙醇胺盐、二氯苯甲醇、对羟基苯乙酮,对茴香酸、山梨酸、辛酰羟肟酸任选其中一种或多种;
c.丙二醇、戊二醇、己二醇、辛二醇至少一种或多种。
2.根据权利要求1所述的一种复配型化妆品防腐剂,其特征在于:所述b组分选自氯苯甘醚、吡罗克酮乙醇胺盐、二氯苯甲醇、对羟基苯乙酮,对茴香酸、山梨酸、辛酰羟肟酸任选其中一种或多种。
3.根据权利要求1所述的一种复配型化妆品防腐剂,其特征在于,按照重量百分比计包括:10-35%的a组分、20-60%的b组分、15-75%的c组分。
4.根据权利要求1所述的一种复配型化妆品防腐剂,其特征在于,所述b组分中按照重量百分比计算:氯苯甘醚为10-20%、吡罗克酮乙醇胺盐10-20%、二氯苯甲醇为10-20%、对羟基苯乙酮10-20%、对茴香酸5-10%、山梨酸5-10%、辛酰羟肟酸10-20%。
5.一种如权利要求1-3任一项所述的复配型化妆品防腐剂的制备方法,其特征在于,包括以下步骤:
将所述a组分山梨坦辛酸酯、b组分任意一种或多种和所述c组分任意一种在40-65℃条件下搅拌均匀,得到复配防腐剂。
6.如权利要求1-3任一项所述的复配型化妆品防腐剂在化妆品中的应用。
7.一种化妆品,其特征在于,所述化妆品内含有防腐物质,所述防腐物质包括权利要求1-3任一项所述的多种防腐剂复配物。
8.根据权利要求7所述的化妆品,其特征在于,所述化妆品中所述含所述防腐剂组合物的用量为0.2-1.8wt%。
9.根据权利要求7所述的化妆品,其特征在于,所述化妆品中所述防腐剂组合物的用量为0.2-0.6wt%。
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