CN117582425A - Muscles and bones plaster - Google Patents
Muscles and bones plaster Download PDFInfo
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- CN117582425A CN117582425A CN202311358233.4A CN202311358233A CN117582425A CN 117582425 A CN117582425 A CN 117582425A CN 202311358233 A CN202311358233 A CN 202311358233A CN 117582425 A CN117582425 A CN 117582425A
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- tendons
- root
- bones
- fracture
- camphor
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- 210000000988 bone and bone Anatomy 0.000 title claims abstract description 35
- 210000003205 muscle Anatomy 0.000 title claims abstract description 12
- 239000011505 plaster Substances 0.000 title abstract description 7
- 210000002435 tendon Anatomy 0.000 claims abstract description 36
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 claims abstract description 15
- 240000007594 Oryza sativa Species 0.000 claims abstract description 15
- 235000007164 Oryza sativa Nutrition 0.000 claims abstract description 15
- 239000000843 powder Substances 0.000 claims abstract description 7
- 238000002360 preparation method Methods 0.000 claims abstract description 7
- 240000006432 Carica papaya Species 0.000 claims description 14
- 235000009467 Carica papaya Nutrition 0.000 claims description 14
- 244000020518 Carthamus tinctorius Species 0.000 claims description 14
- 235000003255 Carthamus tinctorius Nutrition 0.000 claims description 14
- 241000723346 Cinnamomum camphora Species 0.000 claims description 14
- 229960000846 camphor Drugs 0.000 claims description 14
- 229930008380 camphor Natural products 0.000 claims description 14
- 235000013312 flour Nutrition 0.000 claims description 14
- 235000009566 rice Nutrition 0.000 claims description 14
- 235000007270 Gaultheria hispida Nutrition 0.000 claims description 13
- 241000195954 Lycopodium clavatum Species 0.000 claims description 13
- 235000009134 Myrica cerifera Nutrition 0.000 claims description 13
- 244000269152 Myrica pensylvanica Species 0.000 claims description 13
- 235000012851 Myrica pensylvanica Nutrition 0.000 claims description 13
- 239000013505 freshwater Substances 0.000 claims description 13
- 235000002566 Capsicum Nutrition 0.000 claims description 12
- 239000006002 Pepper Substances 0.000 claims description 12
- 235000016761 Piper aduncum Nutrition 0.000 claims description 12
- 235000017804 Piper guineense Nutrition 0.000 claims description 12
- 235000008184 Piper nigrum Nutrition 0.000 claims description 12
- 241000123589 Dipsacus Species 0.000 claims description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- 241000427159 Achyranthes Species 0.000 claims description 8
- 241001116742 Drynaria Species 0.000 claims description 5
- 240000000031 Achyranthes bidentata Species 0.000 claims description 3
- 238000009835 boiling Methods 0.000 claims description 2
- 238000001816 cooling Methods 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- 238000003756 stirring Methods 0.000 claims description 2
- 238000005303 weighing Methods 0.000 claims description 2
- 241000382455 Angelica sinensis Species 0.000 claims 3
- 244000203593 Piper nigrum Species 0.000 claims 2
- 244000025254 Cannabis sativa Species 0.000 claims 1
- 208000010392 Bone Fractures Diseases 0.000 abstract description 25
- 206010017076 Fracture Diseases 0.000 abstract description 24
- 230000000694 effects Effects 0.000 abstract description 18
- 239000003814 drug Substances 0.000 abstract description 16
- 208000014674 injury Diseases 0.000 abstract description 14
- 208000027418 Wounds and injury Diseases 0.000 abstract description 13
- 230000006378 damage Effects 0.000 abstract description 13
- 208000002193 Pain Diseases 0.000 abstract description 11
- 230000036407 pain Effects 0.000 abstract description 11
- 230000008961 swelling Effects 0.000 abstract description 10
- 239000008280 blood Substances 0.000 abstract description 9
- 210000004369 blood Anatomy 0.000 abstract description 9
- 230000017531 blood circulation Effects 0.000 abstract description 5
- 208000026137 Soft tissue injury Diseases 0.000 abstract description 4
- 230000003213 activating effect Effects 0.000 abstract description 4
- 229940126680 traditional chinese medicines Drugs 0.000 abstract description 2
- 241000628997 Flos Species 0.000 abstract 1
- 229940025250 camphora Drugs 0.000 abstract 1
- 239000010238 camphora Substances 0.000 abstract 1
- 241000213006 Angelica dahurica Species 0.000 description 10
- 241000722363 Piper Species 0.000 description 10
- 229940079593 drug Drugs 0.000 description 8
- 230000001737 promoting effect Effects 0.000 description 5
- 235000020097 white wine Nutrition 0.000 description 5
- 241000219144 Abutilon Species 0.000 description 4
- 239000002994 raw material Substances 0.000 description 4
- 235000006264 Asimina triloba Nutrition 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 238000013112 stability test Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000003285 pharmacodynamic effect Effects 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 238000005728 strengthening Methods 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 206010002198 Anaphylactic reaction Diseases 0.000 description 1
- 244000061520 Angelica archangelica Species 0.000 description 1
- 206010063659 Aversion Diseases 0.000 description 1
- 241000282994 Cervidae Species 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 206010013082 Discomfort Diseases 0.000 description 1
- 208000030453 Drug-Related Side Effects and Adverse reaction Diseases 0.000 description 1
- 235000001287 Guettarda speciosa Nutrition 0.000 description 1
- 206010061245 Internal injury Diseases 0.000 description 1
- 208000032912 Local swelling Diseases 0.000 description 1
- 206010067482 No adverse event Diseases 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 244000141353 Prunus domestica Species 0.000 description 1
- 241000329195 Sparganium erectum Species 0.000 description 1
- 208000021945 Tendon injury Diseases 0.000 description 1
- 206010070863 Toxicity to various agents Diseases 0.000 description 1
- 230000001133 acceleration Effects 0.000 description 1
- 231100000215 acute (single dose) toxicity testing Toxicity 0.000 description 1
- 238000011047 acute toxicity test Methods 0.000 description 1
- 208000003455 anaphylaxis Diseases 0.000 description 1
- 210000003056 antler Anatomy 0.000 description 1
- 230000008468 bone growth Effects 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 231100001252 long-term toxicity Toxicity 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000008736 traumatic injury Effects 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
- A61K31/125—Camphor; Nuclear substituted derivatives thereof
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
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Abstract
The invention discloses a muscle and bone patch, belonging to the technical field of traditional Chinese medicines; comprises Oryza Glutinosa powder, chinese liquor, herba Abutili, camphora, rhizoma Drynariae, rhizoma Sparganii, pericarpium Citri Tangerinae, fructus Chaenomelis, radix Dipsaci, radix Angelicae sinensis, carthami flos, herba Lycopodii, achyranthis radix, cortex Acanthopancis, fructus Piperis, and cortex Acanthopancis Radicis on fresh radix Adinae; the whole formula of the plaster for treating fracture and injury of tendons and bones has the effects of activating blood circulation to dissipate blood stasis, relieving swelling and pain and reuniting tendons and bones; is suitable for patients with fracture and injured tendons in early and middle stages, namely patients with fracture and soft tissue injury which are called as modern medicine; the preparation method is simple and easy to implement, the administration route is reasonable, the administration is convenient, the bioavailability is high, and the product quality is stable.
Description
Technical Field
The invention relates to a muscle and bone patch, and belongs to the technical field of traditional Chinese medicines.
Background
In daily life, fracture and injured tendons caused by accidents are difficult to recover, and a lot of pains are often brought to patients. Traumatic injury, injury of tendons and fracture refers to injury or fracture of soft tissue of human body caused by external force or strong force, and the main symptoms are swelling and pain. The external force causes bone fracture and tendon injury, blood stasis and qi stagnation, the pathogenesis changes, the death and qi consumption, qi injury pain, swelling and swelling, external injury, internal injury, blood aversion to the liver, blood stasis and new bone growth, so that after fracture, the patient has local swelling and pain and limited limb functions.
At present, most of the disclosed medicaments for treating fracture and injury of tendons have certain effects. But it is found by research that: some medicines have complex preparation process; some medicines are special in raw materials and difficult to obtain; some medicines take precious medicinal materials such as pilose antler, deer horn and the like as raw materials, so that the cost is high, and the medicines are difficult to bear by common consumers; some medicines use too many traditional Chinese medicine types, so that the production cost is increased; some medicines have a certain effect on treating the injury and fracture of tendons, but the effect is not ideal.
Therefore, it is very necessary to provide a medicament which has obvious curative effects on fracture and injured tendons, takes effect quickly, is safe and has low cost.
Disclosure of Invention
First, the technical problem to be solved
The invention aims to solve the technical problems that the existing medicine for treating fracture and injury of tendons is complex in preparation process, difficult in special acquisition of raw materials, high in cost or not ideal in effect.
(II) technical scheme
In order to solve the technical problems, the invention provides a tendons and bones patch which is prepared from 20-40 g of glutinous rice flour, 20-40 g of water, 3-8 g of white wine, bao Qingbing g of camphor, 2-4 g of rhizoma drynariae, rhizoma sparganii, dried orange peel, papaya, teasel root, chinese angelica, safflower, lycopodium clavatum, achyranthes root, cortex acanthopanacis, 1-5 g of pepper, and 40-80 g of fresh water waxberry root.
As a further improvement of the technical scheme, the tendons and bones paste is specifically prepared from 30 g of glutinous rice flour, 30 g of water, 5 g of white spirit, bao Qingbing, 2 g of camphor each, 3 g of rhizoma drynariae, rhizoma sparganii, dried orange peel, papaya, teasel root, angelica, safflower, lycopodium clavatum, achyranthes root, cortex acanthopanacis, pepper each and 60 g of skin on fresh water waxberry root.
The invention also provides a preparation method of the muscle and bone patch, which comprises the following steps: weighing 30 g of glutinous rice flour and 30 g of water, boiling, cooling, 5 g of white spirit, bao Qingbing g of each of camphor, 2 g of rhizoma drynariae, rhizoma sparganii, dried orange peel, papaya, teasel root, chinese angelica, safflower, lycopodium clavatum, achyranthes bidentata, cortex acanthopanacis, and ground into powder, wherein 3 g of each of the ground powder, 60 g of the skin on fresh water waxberry root are ground into powder, and stirring for external use.
The above mentioned tendons and bones paste has the following study results:
1. pharmacodynamic study
Pharmacodynamic studies show that the tendons and bones paste has the effects of inhibiting inflammatory exudation, promoting the regression of blood stasis and edema and promoting fracture healing. Prompting: the product has effects of promoting blood circulation, removing blood stasis, relieving swelling and pain, and promoting reunion of fractured bones, and can be used for treating fracture, injured tendons in early and middle stages.
2. Acute toxicity test
The tendons and bones plaster 120g, 220g and 320g are respectively spread out and externally applied on the skin of a human body for 12 hours, and the muscles and bones plaster has no local skin allergy and general discomfort. Prompting: the product is safe according to the clinical dosage and the administration route.
3. Long-term toxicity test
The tendons and bones are respectively spread with 120g, 220g and 320g of skin of an external application human body, and are replaced every 3 days, and the tendons and bones are continuously used for 1 month, so that the general condition of the use result is good, and no adverse reaction is seen; the difference between the administration group and the control group has no significance in hematology examination, hematochemistry examination and organ coefficient examination. The pathological histology of the major viscera does not show obvious pathological changes caused by drug toxicity. The results indicate that the tendons and bones patch is safe to use according to the dosage, the route and the treatment course of clinical application.
4. Stability test
The applicant carries out an acceleration stability test and a preliminary stability test on three batches of samples according to the related requirements under the annex plaster item of the edition one of the 'Chinese pharmacopoeia' 2020 edition and the quality standard draft of clinical study medication of the product, and the results show that the product is placed for three months under the conditions of the temperature of 38+/-1 ℃ and the relative humidity of 75% and is placed for six months at the room temperature, and all investigation indexes meet the regulations, so that the product quality is stable. The quality standard can basically control the quality of the product and ensure the objective evaluation of clinical research results. Therefore, the pharmaceutical research work done by the product meets the related requirements of registration and declaration of new Chinese patent medicines.
(III) beneficial effects
The technical scheme of the invention has the following advantages:
compared with the prior art, the muscle and bone patch has the effects of activating blood circulation to dissipate blood stasis, dispelling wind and removing obstruction in collaterals, relieving swelling and pain, strengthening tendons and bones, has obvious curative effects on swelling and pain caused by fracture and soft tissue injury, and is beneficial to recovery of fracture and injured tendons; the preparation method and the finished product have stable quality, definite curative effect, small toxic and side effects, safe clinical application and low cost. The invention adopts ancestral formula, each group distributes and plays a role in synergy, and the cure rate is more than 99 percent.
Compared with the prior art, the invention has the following advantages: is prepared from natural pure traditional Chinese medicine raw materials, has no toxic or side effect, short curative effect, quick response, simple prescription, high cure rate, total effective rate up to 99 percent, no anaphylactic reaction and clinical popularization and application value.
The whole formula of the plaster for treating fracture and injury of tendons and bones provided by the invention has the effects of activating blood circulation to dissipate blood stasis, relieving swelling and pain and promoting reunion of fractured bones. Is suitable for patients with fracture and injured tendons in early and middle stages, namely patients with fracture and soft tissue injury called by modern medicine. The preparation method is simple and easy to implement, the administration route is reasonable, the administration is convenient, the bioavailability is high, and the product quality is stable.
In addition to the technical problems, features of the constituent technical solutions and advantages brought by the technical features of the technical solutions described above, other technical features of the present invention and advantages brought by the technical features of the technical solutions will be further described with reference to the embodiments.
Detailed Description
For the purpose of making the objects, technical solutions and advantages of the embodiments of the present invention more apparent, the technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is apparent that the described embodiments are some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
Example 1
A kind of muscles and bones paste:
the main components are as follows: 30 g of glutinous rice flour, 5 g of white spirit, bao Qingbing g of camphor, 2 g of each, drynaria rhizome, rhizoma sparganii, dried orange peel, papaya, teasel root, chinese angelica, safflower, lycopodium clavatum, achyranthes root, cortex acanthopanacis and pepper, and 60 g of fresh water waxberry root bark.
According to the formula, 30 g of glutinous rice flour and 30 g of water are weighed, cooked and cooled, 5 g of white wine is weighed, 2 g of each of the thin abutilon ice and the camphor is weighed, 3 g of each of rhizoma drynariae, rhizoma sparganii, dried orange peel, pawpaw, radix dipsaci, chinese angelica, safflower, lycopodium clavatum, radix achyranthis bidentatae, cortex acanthopanacis and pepper are ground, 60 g of the skin on fresh water waxberry root is weighed, ground, stirred into paste, and then the paste is filled into a container, and the tendons and bones paste for treating fracture and injury of tendons is prepared.
Example 2
A kind of muscles and bones paste:
the main components are as follows: glutinous rice flour 20g, white spirit 3 g, bao Qingbing g, camphor 1 g each, drynaria rhizome, rhizoma sparganii, dried orange peel, papaya, dipsacus root, chinese angelica, safflower, lycopodium clavatum, achyranthes root, cortex acanthopanacis, pepper 1.5 g each, fresh water waxberry root epithelium 40 g.
According to the formula, 20g of glutinous rice flour and 20g of water are weighed, cooked and cooled, 3 g of white wine is weighed, 1 g of each of the thin abutilon ice and the camphor is weighed, 1.5 g of each of rhizoma drynariae, rhizoma sparganii, dried orange peel, pawpaw, radix dipsaci, chinese angelica, safflower, lycopodium clavatum, radix achyranthis bidentatae, cortex acanthopanacis and pepper are ground, 40 g of the skin on fresh prune root is weighed, ground, stirred into paste, and then the paste is filled into a container, and the tendons and bones paste for treating fracture and injury of tendons is prepared.
Example 3
A kind of muscles and bones paste:
the main components are as follows: 40 g of glutinous rice flour, 8 g of white spirit, bao Qingbing g of camphor, 4 g of each, drynaria rhizome, rhizoma sparganii, dried orange peel, papaya, teasel root, chinese angelica, safflower, lycopodium clavatum, achyranthes root, cortex acanthopanacis and pepper, 5 g of each and 80 g of fresh water waxberry root bark.
40 g of glutinous rice flour and 40 g of water are weighed according to the formula, cooked and cooled, 8 g of white wine is weighed, 4 g of each of the thin abutilon ice and the camphor is weighed, 5 g of each of the drynaria rhizome, the common burreed rhizome, the dried orange peel, the papaya, the teasel root, the Chinese angelica, the safflower, the lycopodium clavatum, the achyranthes root, the cortex acanthopanacis and the pepper are ground, 80 g of the cortex on the fresh water waxberry root is weighed, ground, stirred into paste, and filled into a container, thus obtaining the tendons and bones paste for treating fracture and injury of tendons.
Example 4
A kind of muscles and bones paste:
the main components are as follows: 35 g of glutinous rice flour, 6.5 g of white spirit, bao Qingbing g of camphor, 3 g of rhizoma drynariae, rhizoma sparganii, dried orange peel, papaya, teasel root, chinese angelica, safflower, lycopodium clavatum, achyranthes root, cortex acanthopanacis and pepper, and 70 g of fresh water waxberry root bark.
According to the formula, 35 g of glutinous rice flour and 35 g of water are weighed, cooked and cooled, 6.5 g of white wine is weighed, 3 g of each of the thin abutilon ice and the camphor is weighed, 4.5 g of each of rhizoma drynariae, rhizoma sparganii, dried orange peel, pawpaw, radix dipsaci, chinese angelica, safflower, lycopodium clavatum, radix achyranthis bidentatae, cortex acanthopanacis and pepper are ground, 70 g of the skin on the fresh water waxberry root is weighed, ground, stirred and then the paste is filled into a container, and the tendons and bones paste for treating fracture and injury of tendons is prepared.
If the tendons and bones paste needs industrial production, the production can be expanded according to the proportion.
The traditional Chinese medicine composition has the effects of activating blood circulation to dissipate blood stasis, dispelling wind and dredging collaterals, relieving swelling and pain, strengthening tendons and bones, has obvious curative effects on swelling and pain caused by fracture and soft tissue injury, and is beneficial to recovery of fracture and injured tendons.
While the present invention has been described in detail with reference to the specific embodiments thereof, the present invention is not limited to the above embodiments, and various changes may be made without departing from the spirit of the present invention within the knowledge of those skilled in the art.
Claims (3)
1. Tendons and bones subsides, its characterized in that: the Chinese medicinal composition is prepared from 20-40 g of glutinous rice flour, 20-40 g of water, 3-8 g of white spirit, bao Qingbing g of camphor, 2-4 g of rhizoma drynariae, rhizoma sparganii, dried orange peel, papaya, teasel root, angelica sinensis, safflower, lycopodium clavatum, achyranthes bidentata, cortex acanthopanacis, and 1-5 g of pepper, and 40-80 g of cortex on fresh water waxberry root.
2. The tendon and bone patch of claim 1, wherein: it is prepared from glutinous rice flour 30 g, water 30 g, white spirit 5 g, bao Qingbing, camphor 2 g each, drynaria rhizome, rhizoma sparganii, dried orange peel, papaya, dipsacus root, chinese angelica, safflower, buck grass, achyranthes root, cortex acanthopanacis, pepper 3 g each, and 60 g of fresh water waxberry root bark.
3. The tendon and bone patch of claim 2, wherein: the preparation method of the muscle and bone patch comprises the following steps: weighing 30 g of glutinous rice flour and 30 g of water, boiling, cooling, 5 g of white spirit, bao Qingbing g of each of camphor, 2 g of rhizoma drynariae, rhizoma sparganii, dried orange peel, papaya, teasel root, chinese angelica, safflower, lycopodium clavatum, achyranthes bidentata, cortex acanthopanacis, and ground into powder, wherein 3 g of each of the ground powder, 60 g of the skin on fresh water waxberry root are ground into powder, and stirring for external use.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311358233.4A CN117582425A (en) | 2023-10-19 | 2023-10-19 | Muscles and bones plaster |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311358233.4A CN117582425A (en) | 2023-10-19 | 2023-10-19 | Muscles and bones plaster |
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| Publication Number | Publication Date |
|---|---|
| CN117582425A true CN117582425A (en) | 2024-02-23 |
Family
ID=89919077
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202311358233.4A Pending CN117582425A (en) | 2023-10-19 | 2023-10-19 | Muscles and bones plaster |
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| Country | Link |
|---|---|
| CN (1) | CN117582425A (en) |
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2023
- 2023-10-19 CN CN202311358233.4A patent/CN117582425A/en active Pending
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