CN1175433A - Medicine for treating rheumatoid arthritis and its producing method - Google Patents
Medicine for treating rheumatoid arthritis and its producing method Download PDFInfo
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- CN1175433A CN1175433A CN 96119138 CN96119138A CN1175433A CN 1175433 A CN1175433 A CN 1175433A CN 96119138 CN96119138 CN 96119138 CN 96119138 A CN96119138 A CN 96119138A CN 1175433 A CN1175433 A CN 1175433A
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Abstract
A medicine in the form of oral liquid for treating rheumatoid arthritis with high curative effect and low toxic by-effect is prepared from 12 Chinese-medicinal materials such as orientvine stem, kadsura pepper stem, black ant, etc. through hydrolysis of black ant, regulating pH value to neutraliz, aqueous extraction of others, and mixing.
Description
The present invention relates to a kind of medicine and production method thereof for the treatment of rheumatoid arthritis.
Rheumatoid arthritis, it is the inflammatory diseases in the joint that causes of a kind of anaphylaxis, the little joints of invading extremity more, early stage is local swelling and ankylosis, become tetanic and lopsided late period, antirheumatic class (as salicylic acid etc.) is adopted in treatment, adrenocortical hormone, operative treatment is adopted in physical therapy, acupuncture etc. in case of necessity, but above these Drug therapys all need be taken medicine for a long time, and curative effect is unsatisfactory, physiotherapy must adhere to for a long time that also operative treatment only adopts the heavier patient of symptom, and is the method for curing the symptoms, not the disease.
Purpose of the present invention just is to overcome the shortcoming of present rheumatoid arthritis treatment method, and a kind of therapeutic effect is good, toxic and side effects is little, production technology is simply treated rheumatoid arthritis medicine and production method thereof are provided.
The present invention realizes like this.
Adopt Zaocys, Caulis Sinomenii, Caulis Piperis Kadsurae, Scorpio, Caulis Spatholobi, Flos Carthami, Herba Epimedii, the Radix Paeoniae Alba, Radix Angelicae Sinensis, Radix Rehmanniae Preparata, Herba Taxilli, Formica fusca 12 flavor medicines, the peroral dosage form of making, with oral liquid is good, can realize the purpose of treatment rheumatoid arthritis of the present invention.
Wherein the consumption of Caulis Sinomenii, Caulis Piperis Kadsurae, Caulis Spatholobi, Herba Epimedii, Radix Rehmanniae Preparata, Herba Taxilli is greater than all the other amount of drug, the consumption minimum of Flos Carthami, and the consumption of Scorpio, Formica fusca takes second place.
It is the best that medicine of the present invention is formed with following ratio, 10 parts of Zaocyss, 15 parts of Caulis Sinomeniis, 15 parts of Caulis Piperis Kadsuraes, 5 parts of Scorpios, 15 parts of Caulis Spatholobis, 3 parts on Flos Carthami, 15 parts of Herba Epimedii, 10 parts of the Radix Paeoniae Albas, 10 parts of Radix Angelicae Sinensis, 15 parts in Radix Rehmanniae Preparata, 15 parts of Herba Taxillis, 5 parts of Formica fuscas.Following ratio is a weight ratio.Pharmaceutical formulation is best with the oral liquid.
The medicine production method of treatment rheumatoid arthritis of the present invention is:
Caulis Sinomenii, Caulis Piperis Kadsurae, Caulis Spatholobi, Flos Carthami, Herba Epimedii, the Radix Paeoniae Alba, Radix Angelicae Sinensis, Radix Rehmanniae Preparata, Herba Taxilli unboiled water are carried, and promptly add water to submerge, and water carries twice, filter, and merge extractive liquid, concentrates, Zaocys, and Scorpio extracting in water three times filters merge extractive liquid; The Formica fusca porphyrize, hydrolyzed solution is got in acid hydrolysis, adds alkali and transfers to neutrality, merges with each extracting solution, adds water to full dose promptly.
Zaocys, Caulis Sinomenii, Caulis Piperis Kadsurae wind-damp dispelling in the medicine side of treatment rheumatoid arthritis of the present invention, the meridian dredging.Scorpio controls that the apoplexy arthralgia chiefly caused by damp pathogen is meciless, muscle arteries and veins structure is anxious, arthralgia.Caulis Spatholobi, Flos Carthami dissipating blood stasis collateral dredging.Herba Epimedii, the Radix Paeoniae Alba, Radix Angelicae Sinensis, Radix Rehmanniae Preparata, Herba Taxilli, Formica fusca invigorating the liver and kidney, nourish blood, flourish muscles and bones, sharp joint, all medicine compatibilities are for the Therapeutic Principle who has embodied strengthening vital QI to eliminate pathogenic factors.Drug therapy rheumatoid arthritis good effect of the present invention, toxic and side effects are little, and its production technology is simple.
The invention will be further described below in conjunction with embodiment.
Embodiment 1: 10 parts of Zaocyss, 15 parts of Caulis Sinomeniis, 15 parts of Caulis Piperis Kadsuraes, 5 parts of Scorpios, 15 parts of Caulis Spatholobis, 3 parts on Flos Carthami, 15 parts of Herba Epimedii, 10 parts of the Radix Paeoniae Albas, 10 parts of Radix Angelicae Sinensis, 15 parts in Radix Rehmanniae Preparata, 15 parts of Herba Taxillis, 5 parts of Formica fuscas.Make oral liquid.
Its production method is: Caulis Sinomenii, Caulis Piperis Kadsurae, Caulis Spatholobi, medicine flower, Herba Epimedii, the Radix Paeoniae Alba, Radix Angelicae Sinensis, Radix Rehmanniae Preparata, Herba Taxilli unboiled water are carried, promptly added water to submerge, water carries twice, filters, merge extractive liquid, concentrates Zaocys, gold scorpion extracting in water three times filters merge extractive liquid; The Formica fusca porphyrize, hydrolyzed solution is got in acid hydrolysis, adds alkali and transfers to neutrality, merges with each extracting solution, adds water to full dose promptly.
Embodiment 2: 20 parts of Caulis Sinomeniis, 20 parts of Caulis Piperis Kadsuraes, 5 parts of Scorpios, 10 parts of Zaocyss, 20 parts of Caulis Spatholobis, 3 parts on Flos Carthami, 20 parts of Herba Epimedii, 10 parts of the Radix Paeoniae Albas, 10 parts of Radix Angelicae Sinensis, 20 parts in Radix Rehmanniae Preparata, 20 parts of Herba Taxillis, 5 parts of Formica fuscas, make oral liquid.
Its production method is the same.
Embodiment 3: 15 parts of Zaocyss, 15 parts of Caulis Sinomeniis, 15 parts of Caulis Piperis Kadsuraes, 3 parts of Scorpios, 15 parts of Caulis Spatholobis, 4 parts on Flos Carthami, 15 parts of Herba Epimedii, 10 parts of the Radix Paeoniae Albas, 10 parts of Radix Angelicae Sinensis, 15 parts in Radix Rehmanniae Preparata, 15 parts of Herba Taxillis, 4 parts of Formica fuscas, make oral liquid.
Its production method is the same.
Embodiments of the invention 1 instructions of taking is the each oral oral liquid that is equivalent to the medical material of 133 grams, and once a day, three months is a course of treatment.
Efficacy assessment standard: recovery from illness: symptom all disappears, functional activity recovers normal, the result is normal for main reference index (the erythrocyte sedimentation rate class pathogenic wind-warm factor, immunoglobulin etc.).
Produce effects: arthralgia, swelling disappear or significantly alleviate, and articular morphology and function are recovered normal substantially or significantly recovered.
Take a turn for the better: arthralgia swelling alleviates, and articular morphology makes moderate progress.
Invalid: as to compare all not have before arthralgia swelling, form and function and the treatment and alleviate.
Efficacy analysis: use oral liquid of the present invention and obey 1-4 the course of treatment, by evaluating the criterion of therapeutical effect result: 75 examples of fully recovering account for 75%; Produce effects 15 examples account for 15%; 7 examples that take a turn for the better account for 7%; Invalid 3 examples account for 3%; Total effective rate 97%.
Traditional Chinese medical science typing and therapeutic effect relationship: oral oral liquid patient 100 examples of the present invention, make tcm syndrome differentiation and typing, treatment shows various effect statistical result: this oral liquid is better to Yuxuebi capsule, qi and blood deficiency, caused by liver and kidney deficiency type, curative effect.But to the turbid numbness type of expectorant, cold-evil partially victory type curative effect take second place.
From clinically 100 routine patients are observed, most patients are life-time service 17-hydroxy-11-dehydrocorticosterone or the treatment of other antirheumatic once, and its treatment is imitated unsatisfactory.But most case effects are better after adopting clothes oral liquid treatment of the present invention, other Chinese herbal and crude drugs preparationses of oral liquid of the present invention and domestic report, approximate as curative effects such as Thunder God Teng tincture, Tripterygium hypoglaucum extractum sheets, but be better than other preparation aspect joint deformity, the pain relieving improving.
Poisonous side effect of medicine: to having made the hepatic and renal function check result before and after the 100 routine patient treatments of taking the rheumatoid rehabilitation soup: all normal before and after the hepatic and renal function treatment, show that oral oral liquid of the present invention do not find organ injuries such as liver, kidney.
Model case is introduced
Case (one) patient woods * * 40 years old, secondary school teachers, because of upper limb and wrist joint pain 3 years, the aggravation of swelling and ache are accompanied limitation of activity 1 year, are gone to a doctor October nineteen ninety, the patient was once heavy when light when prednisone, indometacin and the treatment by Chinese herbs symptom, thread is controlled and is not healed, have a medical check-up: the joint is the enlargement of shuttle shape between both hands middle finger near-end, the obvious tenderness of metacarpophalangeal joints, limitation of activity, chemical examination erythrocyte sedimentation rate 56mm/h, the rheumatoid factor positive, the two normal proximal interphalangeal joint of finger of X-ray film prompting have osteoporosis to change, articular surface is coarse, the gap narrows down slightly.Diagnosis: rheumatoid arthritis.Oral liquid posterior joint pain 2 courses of treatment of the present invention is clearly better through taking, arthroncus is obviously disappeared, the function of joint barrier is also significantly improved, is chemically examined erythrocyte sedimentation rate 18mm/h, turning out cloudy property of rheumatoid factor, advises continue clothes oral liquid of the present invention and check after 2 courses of treatment, arthralgia all disappears when examining again, ESR, RF check is normal, the X line shows that osteoporosis also improves, follow up a case by regular visits to 1 year so far, clinical every index is no abnormal, the work of normally going to work.
Case (two) week * * woman, 35 years old, the cadre, go to a doctor at the beginning of 1992 6 months, patient's readme, disease is prolonged 7 years, show as little arthralgia, local swelling, outbreak repeatedly, recently pain increases, especially refer to wrist and the distortion of sick side ankle swelling obviously with the right hand, the stiff phenomenon in morning of having got up morning, the extremity activity is not freely, look into: erythrocyte sedimentation rate speeds, rheumatoid factor is positive, both hands and biped X line anterioposterior and lateral film, as seen both hands 2-5 refers to arthrostenosis between near-end, articular surface is irregular, the epiphysis osteoporosis, right carpal joint is narrow, the joint margins hypertrophy, the slight decalcification of biped phalanx, the sufficient 2-3 phalanx first segment basilar part in the left side sample of giving a farfetched interpretation destroys, be diagnosed as: rheumatoid arthritis, the patient uses enteric coated aspirin for many years repeatly, indometacin, penicillin, poor effect such as prednisone and Chinese medicine, through taking oral liquid of the present invention after 2 courses of treatment, pain, swelling disappears substantially, activity freely, check erythrocyte sedimentation rate 16mm/h, rheumatoid factor negative, advising the clothes oral liquid of the present invention half a year of continuing, for the second time check clinical every index all in normal range, recover operate as normal, followed up a case by regular visits to not recurrence so far in 2 years.
Claims (4)
1. medicine for the treatment of rheumatoid arthritis, be peroral dosage form, its thing is levied and is: adopt Zaocys, Caulis Sinomenii, Caulis Piperis Kadsurae, Scorpio, Caulis Spatholobi, Flos Carthami, Herba Epimedii, the Radix Paeoniae Alba, Radix Angelicae Sinensis, Radix Rehmanniae Preparata, Herba Taxilli, Formica fusca 12 flavor medicines, the peroral dosage form of making is good with oral liquid.
2. a kind of medicine for the treatment of rheumatoid arthritis according to claim 1, it is characterized in that: drug dose is that the consumption of Caulis Sinomenii, Caulis Piperis Kadsurae, Caulis Spatholobi, Herba Epimedii, Radix Rehmanniae Preparata, Herba Taxilli is greater than all the other amount of drug, the consumption minimum of Flos Carthami, the consumption of Scorpio, Formica fusca takes second place.
3. a kind of medicine for the treatment of rheumatoid arthritis according to claim 1, it is characterized in that: pharmaceutical formulation is 10 parts of good Zaocyss, 15 parts of Caulis Sinomeniis, 15 parts of Caulis Piperis Kadsuraes, 5 parts of Scorpios, 15 parts of Caulis Spatholobis, 3 parts on Flos Carthami, 15 parts of Herba Epimedii, 10 parts of the Radix Paeoniae Albas, 10 parts of Radix Angelicae Sinensis, 15 parts in Radix Rehmanniae Preparata, 15 parts of Herba Taxillis, 5 parts of Formica fuscas with following ratio, more than is weight ratio.
4. the medicine production method of a treatment rheumatoid arthritis as claimed in claim 1, it is characterized in that: Caulis Sinomenii, Caulis Piperis Kadsurae, Caulis Spatholobi, Flos Carthami, Herba Epimedii, the Radix Paeoniae Alba, Radix Angelicae Sinensis, Radix Rehmanniae Preparata, Herba Taxilli unboiled water are carried, promptly add water to submerge, water carries twice, filters merge extractive liquid,, concentrate, Zaocys, Scorpio extracting in water three times filter merge extractive liquid; The Formica fusca porphyrize, hydrolyzed solution is got in acid hydrolysis, adds alkali and transfers to neutrality, merges with each extracting solution, adds water to full dose promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 96119138 CN1175433A (en) | 1996-08-30 | 1996-08-30 | Medicine for treating rheumatoid arthritis and its producing method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 96119138 CN1175433A (en) | 1996-08-30 | 1996-08-30 | Medicine for treating rheumatoid arthritis and its producing method |
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| Publication Number | Publication Date |
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| CN1175433A true CN1175433A (en) | 1998-03-11 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 96119138 Pending CN1175433A (en) | 1996-08-30 | 1996-08-30 | Medicine for treating rheumatoid arthritis and its producing method |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002069971A1 (en) * | 2001-03-05 | 2002-09-12 | Molecular Biology Limited | Pharmaceutical compositions and dietary supplements for treatment or improvement of arthitis |
| CN100493589C (en) * | 2004-11-24 | 2009-06-03 | 香港赛马会中药研究院有限公司 | Herbal medical preparation for the treatment of arthritis |
| CN100593412C (en) * | 2007-08-13 | 2010-03-10 | 焦彬 | Chinese medicine composition for treating rheumatoid arthritis and method for preparing the same |
| CN101406688B (en) * | 2008-11-28 | 2010-12-22 | 魏玉玲 | Compound formulation for treating rheumatic arthritis and rheumatoid arthritis |
| CN104815018A (en) * | 2015-05-27 | 2015-08-05 | 苗怡文 | Traditional Chinese medicine for treating rheumatoid arthritis and preparation method of traditional Chinese medicine |
-
1996
- 1996-08-30 CN CN 96119138 patent/CN1175433A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002069971A1 (en) * | 2001-03-05 | 2002-09-12 | Molecular Biology Limited | Pharmaceutical compositions and dietary supplements for treatment or improvement of arthitis |
| CN100493589C (en) * | 2004-11-24 | 2009-06-03 | 香港赛马会中药研究院有限公司 | Herbal medical preparation for the treatment of arthritis |
| CN100593412C (en) * | 2007-08-13 | 2010-03-10 | 焦彬 | Chinese medicine composition for treating rheumatoid arthritis and method for preparing the same |
| CN101406688B (en) * | 2008-11-28 | 2010-12-22 | 魏玉玲 | Compound formulation for treating rheumatic arthritis and rheumatoid arthritis |
| CN104815018A (en) * | 2015-05-27 | 2015-08-05 | 苗怡文 | Traditional Chinese medicine for treating rheumatoid arthritis and preparation method of traditional Chinese medicine |
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