CN101623460B - Medicine for treating rheumatic pain and preparation method thereof - Google Patents
Medicine for treating rheumatic pain and preparation method thereof Download PDFInfo
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- CN101623460B CN101623460B CN2009100750967A CN200910075096A CN101623460B CN 101623460 B CN101623460 B CN 101623460B CN 2009100750967 A CN2009100750967 A CN 2009100750967A CN 200910075096 A CN200910075096 A CN 200910075096A CN 101623460 B CN101623460 B CN 101623460B
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Abstract
The invention relates to a medicine for treating rheumatic pain, which is prepared by adopting the following steps: evenly mixing scorpion, pearl barley, entadae stem, divaricate saposhnikovia root, notopterygium root, radix angelicae pubescentis, radix fici hirtae, muskiness, liquorice, Indian damnacanthus herb, angelica, sichuan lovage rhizome, schefflera arboricola, semen brassicae, yellow pepper, skimmia, processed radix aconiti, large-leaved gentian, chilopod, long-noded pit viper and processed semen strychni, grinding into 100-120 meshes of medicinal powders, and packaging into capsules to obtain the finished product. The medicine for treating the rheumatic pain has the advantages of treatment focusing on relieving both the secondary and primary symptoms, exact effect and rapid healing, is remarkably superior to nonsteroidal anti-inflammatory western drugs, such as indometacin, and the like on both recent and long-term treating effects, has no any toxic and side effect and anaphylactic reaction, and achieves 97.5 of total effective ratio displayed by a clinical test result.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of rheumatic arthralgia, particularly relating to a kind of is the medicine of the treatment rheumatic arthralgia of crude drug preparation with Chinese medicine.The invention still further relates to the preparation method of this medicine.
Background technology
Rheumatic arthralgia is the limbs joint pain that causes because of the damp and hot heresy of human feeling's wind and cold, miserable numbness, the enlargement distortion, stiff severe pain, it is unfavorable that layer is stretched, moving obstacle is the disease of cardinal symptom, and common having is outstanding between rheumatism, rheumatoid, gout, lumbar vertebra, ankylosing spondylitis, femur head necrosis and senile osteoarthritis etc.Have gradually clinically, outbreak repeatedly, touching difficulty more is its characteristics, thereby is common clinically a kind of comparatively thorny difficult and complicated illness.
At present both at home and abroad for the treatment of rheumatic arthralgia still based on hormone and immunosuppressant, mainly be antiinflammatory, pain relieving, rheumatism.These allopathy both had been difficult for radical cure, and toxic and side effects is very big, and regular meeting causes vicious cycle.The more important thing is,, cause body's immunity to be lacked of proper care again owing to destroyed the ecological balance of human body.
Summary of the invention
The purpose of this invention is to provide a kind of medicine for the treatment of rheumatic arthralgia, the various typical case of this Drug therapy rheumatic arthralgia is ailing, and cure rate height, relapse rate are low.
Medicine of the present invention is that crude drug prepares by following parts by weight of traditional Chinese medicines:
Scorpio 8～15 Semen Coiciss 20～40 Caulis Entadae 8～15
Radix Saposhnikoviae 8～15 Rhizoma Et Radix Notopterygiis 8～15 Radix Angelicae Pubescentiss 8～15
Radix Fici Hirtae 10～20 Moschus 1～3 Radix Glycyrrhizae 3～8
Herba Damnacanthi 20～40 Radix Angelicae Sinensis 10～20 Rhizoma Chuanxiongs 10～20
Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 8～15 Semen Sinapis Albaes 10～15 yellow pepper 20～40
Caulis Et Folium Skimmiae 2～5 Radix Aconiti Preparatas 3～8 Radix Gentianae Macrophyllae 10～15
Scolopendra 3～8 Agkistrodons 3～8 Semen Strychni (processed)s 3～8.
Further, medicine of the present invention is that crude drug prepares by following parts by weight of traditional Chinese medicines:
Scorpio 10 Semen Coiciss 30 Caulis Entadae 10
Radix Saposhnikoviae 10 Rhizoma Et Radix Notopterygiis 10 Radix Angelicae Pubescentiss 10
Radix Fici Hirtae 15 Moschus 1.5 Radix Glycyrrhizaes 6
Herba Damnacanthi 30 Radix Angelicae Sinensis 15 Rhizoma Chuanxiongs 15
Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 10 Semen Sinapis Albaes 12 yellow pepper 30
Caulis Et Folium Skimmiae 3 Radix Aconiti Preparatas 6 Radix Gentianae Macrophyllae 12
Scolopendra 6 Agkistrodons 6 Semen Strychni (processed)s 6.
Said medicine can be made any dosage form on the pharmaceutics, as tablet, pill, powder, capsule etc., the preferred dosage form of the present invention is a capsule.
The preparation method that above-mentioned each component is made medicine of the present invention is that above-mentioned parts of medicines by weight is mixed, and is ground into 100～120 purpose medicated powder, and in incapsulating, sterilization makes the capsule product.
Radix Aconiti Preparata that is adopted among the present invention and Semen Strychni(processed) all adopt in the pharmacopeia method to concoct and form, and wherein, Radix Aconiti Preparata is that Radix Aconiti is soaked in water to the interior no dried heart, adds water boil 4～6 hours, and taking out dries in the air to sixty percent does, section, and drying is made.Semen Strychni (processed) is sand Semen Strychni (processed) or oily Semen Strychni (processed).The sand Semen Strychni (processed) is that clean Semen Strychni is fried to expanding with sand, takes out during inner pale brown color and gets; The oil Semen Strychni (processed) is that clean Semen Strychni is fried to expanding in vegetable oil, takes out during inner pale brown color and gets.
The rheumatic arthralgia of motherland's medical science, insensitive impediment are equivalent to rheumatic arthritis, the rheumatoid arthritis of modern medicine." element is asked the numbness opinion " said: " wind, cold, wet three gas are assorted extremely, close and be numbness also ".But arthromyodynia and insensitive impediment person are often comparatively obstinate, and it is many to control weary effect person's tool repeatly, and there are plenty of such people for year person of accumulating in the course of time, and the person is not rarely seen yet due to the turbid blood stasis of expectorant, and deficiency and excess is also seen, and is intricate.If single with gentle agent, expelling wind and cold wins the method that wets and led to, and real difficulty is gathered effect.And on the basis of the above, the violent agent of poison, insects are searched and pick, and clearing away phlegm and removing blood stasis but often obtains good effect.In the prescription of the present invention, Radix Saposhnikoviae, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae), Semen Coicis, Radix Fici Hirtae, Radix Gentianae Macrophyllae, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, Caulis Entadae, Radix Angelicae Sinensis, Rhizoma Chuanxiong expelling wind and dampness, activating collaterals to relieve pain; The Semen Sinapis Albae warming for resolving cold-phlegm, dispersing swelling and dissipating binds; The Herba Damnacanthi expelling wind and removing dampness, promoting blood circulation and detumescence is managed all wind diseases that swell and ache; Caulis Et Folium Skimmiae, yellow pepper detumescence are dispelled contraction suddenly, and strengthening bone and muscle is for treating sufficient weakness, the good medicine of Zhitan paralysis; The Moschus blood circulation promoting and blood stasis dispelling; Radix Aconiti Preparata, Semen Strychni (processed), Scorpio, Scolopendra, Agkistrodon poisonous drugs, insects are searched and pick, clearing away phlegm and removing blood stasis, dispersing swelling and dissipating binds, Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription again.All medicine phases 5, detumescence is dispelled contraction suddenly, and strong muscles and bones is treated a little less than the flaccidity of the limbs, and all bones that disappears are swollen, the Zhitan paralysis, expelling wind and cold, victory humidifying expectorant, blood circulation promoting and blood stasis dispelling, easing joint movement, pain relieving rapidly, it is lasting to act on, efficacy consolidation, most patients can effect a radical cure.
For further investigating the clinical efficacy and the safety of medicine of the present invention, select rheumatic arthralgia patient 200 examples to carry out clinical observation on the therapeutic effect.
In the 200 routine cases, male 60 examples, women 140 examples, 14～83 years old age, average 49 years old; The course of disease one week～15 year.Upper limb joint merges cervical pain 112 examples, joint of the lower extremity flank pain 88 examples.
The diagnosis basis of diagnostic criteria basis " traditional Chinese medical science disease diagnosis and treatment standard " rheumatism numbness: 1, walk to scurry pain based on the big joint of extremity, the companion is weighing, miserable, numb, joint joint stuffiness, and symptoms such as aversion to cold, heating are arranged more; 2, before the disease pharyngalgia tonsillitis history is arranged more, or paddle and drench with rain, occupy the wetland history for a long time; 3, the part patient can have low grade fever, extremity erythema iris, or erythema nodosum.But normal heart is got involved; 4, erythrocyte sedimentation rate speeds, and antistreptolysin " O " is greater than 500 units.
Therapeutic Method: take product of the present invention, every day 3 times, each 3～8 grams (obey 3 grams first, increase to 8 grams gradually) according to the state of an illness, early, take half an hour after noon, supper.
Efficacy assessment standard is drafted with reference to " the arthromyodynia opinion is made a study of subjects ", " rheumatoid arthritis " related content according to " the clinical research guideline of treatment by Chinese herbs arthromyodynia ", is divided into healing, improvement, does not heal.
Cure: transference cure, joint motion is normal, and lab testing is normal;
Take a turn for the better: symptom is clearly better, and lab testing has improvement;
Do not heal: symptom and lab testing do not have progress.
The statistics therapeutic outcome is: cure 176 examples, and 19 examples that take a turn for the better, 5 examples do not heal.Total effective rate reaches 97.5%.
Clinical observation on the therapeutic effect is the result prove, Drug therapy rheumatic arthralgia treating both the principal and secondary aspects of a disease of the present invention, characteristics with precise effects and rapid healing, recent and late result all obviously is better than non-steroidal anti-inflammatory Western medicine such as indomethacin, without any side effects and anaphylaxis, and dosage is few, and is cheap, and the patient is easy to accept.
The specific embodiment
Embodiment 1
It is evenly mixed to take by weighing Scorpio 120g, the Semen Coicis 250g, Caulis Entadae 120g, Radix Saposhnikoviae 120g, Rhizoma Et Radix Notopterygii 80g, Radix Angelicae Pubescentis 80g, Radix Fici Hirtae 100g, Moschus 20g, Radix Glycyrrhizae 50g, Herba Damnacanthi 300g, Radix Angelicae Sinensis 200g, Rhizoma Chuanxiong 200g, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 120g, Semen Sinapis Albae 100g, yellow pepper 250g, Caulis Et Folium Skimmiae 40g, Radix Aconiti Preparata 50g, Radix Gentianae Macrophyllae 150g, Scolopendra 50g, Agkistrodon 50g, the Semen Strychni (processed) 50g that choose clean impurity, be ground into 100 purpose medicated powder altogether, pack in No. 0 capsule, sterilization makes the capsule product.
Embodiment 2
It is evenly mixed to take by weighing Scorpio 100g, the Semen Coicis 300g, Caulis Entadae 100g, Radix Saposhnikoviae 100g, Rhizoma Et Radix Notopterygii 100g, Radix Angelicae Pubescentis 100g, Radix Fici Hirtae 150g, Moschus 15g, Radix Glycyrrhizae 60g, Herba Damnacanthi 300g, Radix Angelicae Sinensis 150g, Rhizoma Chuanxiong 150g, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 100g, Semen Sinapis Albae 120g, yellow pepper 300g, Caulis Et Folium Skimmiae 30g, Radix Aconiti Preparata 60g, Radix Gentianae Macrophyllae 120g, Scolopendra 60g, Agkistrodon 60g, the Semen Strychni (processed) 60g that choose clean impurity, be ground into 120 purpose medicated powder altogether, pack in No. 0 capsule, sterilization makes the capsule product.
Application examples 1
Patient Lu, 17 years old.First visit on April 3 in 2006.
Walk 3 kilometers go to school on foot every day before 3 years, and because of the weather severe cold, a snowstorm is raging, and the beginning feels and refers to carpal joint migration twinge, be developed to shoulder, elbow joint gradually, twinge string hip, knee joint after 1 year, reach ankle, in the past few years seek medical advice everywhere to foot, heavy when time thes be light, unsatisfactory curative effect increases the weight of over the past half year.Promptly examine: whole body joint migration pain, with two knee joints, two wrist, both hands refer to, the biped toe more so, symmetrical swelling, pain unbearably, joint deformity is typical fusiformis and refers to that rise stiff morning, climate change, all cards increase the weight of, and obey prednisone 150mg every day, still can not disease controlling.Can't take care of oneself, be forced to suspend schooling.Have a medical check-up: corpulent tongue is big, purplish tongue, and there is petechia at the edge, and stringy and hesitant pulse is unable.Lab testing erythrocyte sedimentation rate 80mm/h, antistreptolysin " O " positive, the rheumatoid factor positive, the slight decalcification of X line film making prompting two knee joints, amyotrophy, capsule on the patella of both sides, capsule is all smudgy down, examines to be rheumatoid arthritis, belongs to wind-cold damp pathogen invasion and attack human body, the meridians impatency, disorder of QI and blood, retardance with the passing of time, due to the turbid blood stasis of expectorant.Control suitable expelling wind and cold, win humidifying expectorant.
Every day three one after each meal medicines of the present invention, starting dose each 3 the gram, take hormone simultaneously.Take that the state of an illness subtracts slightly after 15 days, hormone reduces by half, and strengthening drug dose of the present invention is each 6 grams.After obeying 15 days again, all proofs are apparent to be alleviated, and function of joint is improved, and strengthening consumption is each 8 grams, and hormone all removes.With one month be a course of treatment, after two courses of treatment of continuing to take medicine, pain and swelling disappears, the extremity activity freely, life can be taken care of oneself.Continue to take medicine three courses of treatment, all cards are all known, and recover school work.The heavy 5mm/h that has a blood test, antistreptolysin " O " feminine gender, rheumatoid factor negative.X line film making prompting: do not see the obvious sclerotin change in joint.For consolidating curative effect, three courses of treatment are taken in annual Winter-Spring, serve on 3 years.Visit so far, disease does not recur.
Application examples 2
Patient Zhang, woman, 45 years old now.First visit on January 6 in 2006.
Suffered from sciatica and hyperosteogeny 8 years, and showed as that to turn round walking all very difficult, the sincere pain of right side waist hip, lower limb can not be stretched, emaciated physique, inappetence, through draw for a long time, equal poor effect such as massage, acupuncture.Every day on January 18th, 2006 beginning three one after each meal medicines of the present invention, each 3 grams of starting dose obeys that the state of an illness subtracts slightly after 3 days, escalated dose is taken recovery from illness after 6 months to each 6 grams, can carry out certain physical work, does not recur so far.
Claims (4)
1. medicine for the treatment of rheumatic arthralgia is that crude drug prepares by following parts by weight of traditional Chinese medicines:
Scorpio 8～15 Semen Coiciss 20～40 Caulis Entadae 8～15
Radix Saposhnikoviae 8～15 Rhizoma Et Radix Notopterygiis 8～15 Radix Angelicae Pubescentiss 8～15
Radix Fici Hirtae 10～20 Moschus 1～3 Radix Glycyrrhizae 3～8
Herba Damnacanthi 20～40 Radix Angelicae Sinensis 10～20 Rhizoma Chuanxiongs 10～20
Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 8～15 Semen Sinapis Albaes 10～15 yellow pepper 20～40
Caulis Et Folium Skimmiae 2～5 Radix Aconiti Preparatas 3～8 Radix Gentianae Macrophyllae 10～15
Scolopendra 3～8 Agkistrodons 3～8 Semen Strychni (processed)s 3～8.
2. the medicine of treatment rheumatic arthralgia according to claim 1 is that crude drug prepares by following parts by weight of traditional Chinese medicines:
Scorpio 10 Semen Coiciss 30 Caulis Entadae 10
Radix Saposhnikoviae 10 Rhizoma Et Radix Notopterygiis 10 Radix Angelicae Pubescentiss 10
Radix Fici Hirtae 15 Moschus 1.5 Radix Glycyrrhizaes 6
Herba Damnacanthi 30 Radix Angelicae Sinensis 15 Rhizoma Chuanxiongs 15
Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 10 Semen Sinapis Albaes 12 yellow pepper 30
Caulis Et Folium Skimmiae 3 Radix Aconiti Preparatas 6 Radix Gentianae Macrophyllae 12
Scolopendra 6 Agkistrodons 6 Semen Strychni (processed)s 6.
3. the medicine of treatment rheumatic arthralgia according to claim 1 and 2 is characterized in that described medicine is made capsule.
4. the preparation method of the medicine of the described treatment rheumatic arthralgia of claim 3 is that above-mentioned parts of medicines by weight is mixed, and is ground into 100～120 purpose medicated powder, and in incapsulating, sterilization makes the capsule product.
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| CN2009100750967A CN101623460B (en) | 2009-08-05 | 2009-08-05 | Medicine for treating rheumatic pain and preparation method thereof |
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| CN2009100750967A CN101623460B (en) | 2009-08-05 | 2009-08-05 | Medicine for treating rheumatic pain and preparation method thereof |
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| CN101623460B true CN101623460B (en) | 2011-01-26 |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1286102A (en) * | 2000-09-11 | 2001-03-07 | 张国光 | 'Wanpitong' capsule for treating numbness |
| CN1382459A (en) * | 2001-04-22 | 2002-12-04 | 鲍远祥 | Chinese-medicinal capsule for treating rheumatic or rheumatoid arthritis and its preparing process |
| CN101095843A (en) * | 2006-05-11 | 2008-01-02 | 李石滚 | Pills for treating rheumatism and strengthening muscle |
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- 2009-08-05 CN CN2009100750967A patent/CN101623460B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1286102A (en) * | 2000-09-11 | 2001-03-07 | 张国光 | 'Wanpitong' capsule for treating numbness |
| CN1382459A (en) * | 2001-04-22 | 2002-12-04 | 鲍远祥 | Chinese-medicinal capsule for treating rheumatic or rheumatoid arthritis and its preparing process |
| CN101095843A (en) * | 2006-05-11 | 2008-01-02 | 李石滚 | Pills for treating rheumatism and strengthening muscle |
Non-Patent Citations (3)
| Title |
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| 李学勇等.中医药治疗类风湿性关节炎研究进展.《实用中西医结合临床》.2007,第7卷(第1期), * |
| 郭辉等.中药治疗类风湿性关节炎.《食品与药品》.2007,第9卷(第01A期), * |
| 陈晓明等.类风湿性关节炎中医临床用药策略探讨.《世界中医药》.2008,第3卷(第1期), * |
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