CN117530976A - Composition and method for treating temporomandibular arthritis - Google Patents
Composition and method for treating temporomandibular arthritis Download PDFInfo
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- CN117530976A CN117530976A CN202311665544.5A CN202311665544A CN117530976A CN 117530976 A CN117530976 A CN 117530976A CN 202311665544 A CN202311665544 A CN 202311665544A CN 117530976 A CN117530976 A CN 117530976A
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/236—Ligusticum (licorice-root)
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- A—HUMAN NECESSITIES
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- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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Abstract
The invention relates to the field of temporomandibular arthritis medicines, and discloses a composition and a method for treating temporomandibular arthritis, wherein the composition comprises the following raw materials, by mass, 20% -40% of Chinese angelica, 10% -30% of pseudo-ginseng, 10% -20% of radix angelicae, 10% -20% of safflower, 5% -15% of mulberry leaf, 3% -10% of liquorice, 1% -5% of radix sileris, 1% -5% of ligusticum, and 0.5% -2% of prepared rehmannia root; the preparation method of the composition comprises the following method steps: step one, preparing angelica, pseudo-ginseng, angelica dahurica, safflower, mulberry leaf, liquorice, radix sileris, ligusticum chuanxiong, ligusticum sinense and prepared rehmannia root, and ensuring the quality and purity of the Chinese herbal medicine. The prepared composition finished product is used for treating temporomandibular arthritis, can avoid side effects and dependence of medicines caused by modern technology treatment when the temporomandibular arthritis is treated, and can comprehensively condition the physical condition of a patient, improve the symptoms of temporomandibular arthritis and promote rehabilitation.
Description
Technical Field
The invention relates to the technical field of temporomandibular arthritis medicines, in particular to a composition and a method for treating temporomandibular arthritis.
Background
Temporomandibular arthritis is a common oral-maxillofacial disease affecting the normal function of the temporomandibular joint and its surrounding tissues, and is also known as temporomandibular joint disorder; the temporomandibular joint is a bilateral joint connecting the temporomandibular bone and the mandible, and consists of a articular disc, a joint capsule and articular cartilage.
In the prior art, temporomandibular arthritis is treated by over-the-counter drug combinations, physical therapy combinations, oral appliance combinations and oral appliance combinations, while pain relief and inflammation relief by over-the-counter drug combination treatment may cause side effects, leading to gastrointestinal problems and kidney damage, and long-term or excessive use of certain drugs may increase cardiovascular risk; meanwhile, the oral appliance needs corresponding time to adapt, and wearing the oral appliance causes discomfort, dental ulcer or oral infection, and improper or improper use of the appliance can cause problems of occlusion, tooth displacement or temporomandibular joint instability.
Accordingly, one skilled in the art would provide a composition and method for treating temporomandibular arthritis that addresses the problems set forth in the background above.
Disclosure of Invention
In view of the shortcomings of the prior art, the present invention provides a composition and method for treating temporomandibular arthritis that addresses the problems of pain relief and inflammation relief, side effects that can cause gastrointestinal problems and kidney damage, and cardiovascular risk that long-term or excessive use of certain drugs can increase with over-the-counter drug combination therapy.
In order to achieve the above purpose, the invention is realized by the following technical scheme: the composition for treating the temporomandibular arthritis comprises the following raw materials, by mass, 20% -40% of Chinese angelica, 10% -30% of pseudo-ginseng, 10% -20% of dahurian angelica root, 10% -20% of safflower, 5% -15% of mulberry leaf, 3% -10% of liquorice, 1% -5% of radix sileris, 1% -5% of szechuan lovage rhizome, 1% -5% of Chinese ligusticum rhizome and 0.5% -2% of prepared rehmannia root;
the preparation method of the composition comprises the following method steps:
step one, preparing angelica, pseudo-ginseng, angelica dahurica, safflower, mulberry leaf, liquorice, radix sileris, ligusticum chuanxiong, ligusticum sinense and prepared rehmannia root, and ensuring the quality and purity of the Chinese herbal medicine;
grinding the Chinese angelica, the pseudo-ginseng, the angelica dahurica, the safflower, the mulberry leaf, the liquorice, the divaricate saposhnikovia root, the szechuan lovage rhizome, the ligusticum and the prepared rehmannia root;
step three, accurately weighing the weight of the Chinese herbal medicines according to the formula proportion, and filling the Chinese herbal medicines in the proportion into a container;
step four, putting the weighed Chinese herbal medicines into a container, and stirring to uniformly mix the Chinese herbal medicines;
step five, adding auxiliary materials into the mixed Chinese herbal medicines according to the requirements;
and step six, adding a proper amount of solvent comprising water and alcohol, and uniformly stirring the Chinese herbal medicine and the solvent through a stirrer or a stirring rod to ensure that the preparation of a finished product of the composition is finished.
Preferably, in the second step, the grinding time of the angelica, the safflower, the mulberry leaf and the ligusticum is 1-3 min, the grinding time of the pseudo-ginseng and the ligusticum wallichii is 5-10 min, and the grinding time of the angelica dahurica, the liquorice, the radix sileris and the prepared rehmannia root is 3-5 min.
Preferably, in the fourth step, the stirring speed of the Chinese angelica, the dahurian angelica root, the safflower, the mulberry leaf and the Chinese ligusticum is 200-500 r/min, and the stirring speed of the pseudo-ginseng, the liquorice, the divaricate saposhnikovia root, the szechuan lovage rhizome and the prepared rehmannia root is 500-1000 r/min.
Preferably, the ratio of water to Chinese herbal medicine in the step six is 1:5-1:10, and the concentration of alcohol is 30% -70%.
A method of using a composition for treating temporomandibular arthritis comprising the steps of:
s1, smearing the prepared composition finished product on a medicinal film with proper size, and ensuring uniform distribution of the composition;
s2, cleaning the skin of the temporomandibular joint area with warm water and a non-irritating detergent;
s3, uniformly attaching the medicinal film of the finished product of the coating composition to the temporomandibular joint area;
s4, massaging muscles around the medical film or performing hot compress around the medical film by using a hot compress article, wherein the hot compress comprises a hot water bag or a hot towel.
Preferably, the temperature range of the warm water in the S2 is 37-40 ℃.
Preferably, the temperature interval of the hot compress in the step S4 is 40-45 ℃.
The present invention provides a composition and method for treating temporomandibular arthritis. The beneficial effects are as follows:
1. the invention realizes the treatment of temporomandibular arthritis by the finished product of the composition prepared from angelica, pseudo-ginseng, angelica dahurica, safflower, mulberry leaf, liquorice, radix sileris, ligusticum wallichii, ligusticum sinense and prepared rehmannia root, can avoid the side effect and dependence of the medicine brought by the modern technology treatment, and the finished product of the composition can comprehensively condition the physical condition of patients, improve the symptoms of temporomandibular arthritis and promote rehabilitation, and simultaneously promote blood circulation, relax tendons and activate collaterals and regulate qi-blood balance.
2. According to the invention, the medicinal film coated with the composition is uniformly adhered to the front of the temporomandibular joint area, the skin of the temporomandibular joint area is cleaned by warm water and a non-irritating detergent, and the surrounding muscles coated with the medicinal film are subjected to hot compress, so that the muscles are relaxed, the blood circulation is improved, the permeability of the skin is improved, and the medicine absorption effect is further improved.
Detailed Description
The following description of the present invention will be made clearly and fully, and it is apparent that the embodiments described are only some, but not all, of the embodiments of the present invention. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
Embodiment one:
the embodiment of the invention provides a composition for treating temporomandibular arthritis, wherein the composition comprises the following raw materials in percentage by mass, 30% of Chinese angelica, 20% of pseudo-ginseng, 15% of dahurian angelica root, 15% of safflower, 10% of mulberry leaf, 5% of liquorice, 3% of divaricate saposhnikovia root, 1% of szechuan lovage rhizome, 1% of Chinese ligusticum rhizome and 0.5% of prepared rehmannia root;
a method of preparing a composition comprising the method steps of:
step one, preparing angelica, pseudo-ginseng, angelica dahurica, safflower, mulberry leaf, liquorice, radix sileris, ligusticum chuanxiong, ligusticum sinense and prepared rehmannia root, and ensuring the quality and purity of the Chinese herbal medicine;
grinding the Chinese angelica, the pseudo-ginseng, the angelica dahurica, the safflower, the mulberry leaf, the liquorice, the divaricate saposhnikovia root, the szechuan lovage rhizome, the ligusticum and the prepared rehmannia root;
step three, accurately weighing the weight of the Chinese herbal medicines according to the formula proportion, and filling the Chinese herbal medicines in the proportion into a container;
step four, putting the weighed Chinese herbal medicines into a container, and stirring to uniformly mix the Chinese herbal medicines;
step five, adding auxiliary materials into the mixed Chinese herbal medicines according to the requirements;
and step six, adding a proper amount of solvent comprising water and alcohol, and uniformly stirring the Chinese herbal medicine and the solvent through a stirrer or a stirring rod to ensure that the preparation of a finished product of the composition is finished.
Grinding time of Chinese angelica, safflower, mulberry leaf and ligusticum in the second step is 2min, grinding time of pseudo-ginseng and ligusticum chuanxiong is 8min, grinding time of radix angelicae, liquorice, radix saposhnikoviae and prepared rehmannia root is 4min, stirring speed of Chinese angelica, radix angelicae, safflower, mulberry leaf and ligusticum in the fourth step is 350r/min, stirring speed of pseudo-ginseng, liquorice, radix saposhnikoviae, ligusticum chuanxiong and prepared rehmannia root is 750r/min, proportion of water and Chinese herbal medicine in the sixth step is 1:8, and concentration of alcohol is 45%.
The angelica has the effects of promoting blood circulation, removing blood stasis and nourishing blood, and can improve pain and swelling caused by temporomandibular arthritis; notoginseng radix has effects of promoting blood circulation, removing blood stasis, relieving rigidity of muscles, activating collaterals, and relieving arthritis symptoms; radix Angelicae Dahuricae has effects of dispelling pathogenic wind, dispelling cold, promoting blood circulation, and relieving pain, and can relieve discomfort of temporomandibular arthritis; the safflower has the effects of activating blood circulation to dissipate blood stasis, and relieving swelling and pain, and has certain help to relieve the arthritis symptoms; the mulberry leaves have the effects of clearing heat and detoxicating, promoting blood circulation and removing blood stasis, and can reduce inflammatory reaction; the licorice has the effects of resisting inflammation, easing pain and harmonizing drug property, and has certain effects of relieving pain and relieving inflammation; radix Saposhnikoviae has effects of dispelling pathogenic wind and cold, promoting blood circulation, and relieving pain, and can improve discomfort caused by arthritis; ligusticum wallichii has the effects of activating blood circulation to dissipate blood stasis, relaxing tendons and activating collaterals, and is helpful for relieving the symptoms of arthritis; ligusticum sinense has the effects of promoting blood circulation, removing blood stasis, relieving swelling and pain, and improving discomfort caused by arthritis; the prepared rehmannia root has the effects of nourishing yin and blood, promoting blood circulation and removing blood stasis, and can improve symptoms caused by arthritis; meanwhile, the grinding step in the preparation method is beneficial to smashing the Chinese herbal medicines into fine powder, increasing the solubility and releasing the drug effect, the stirring step is used for uniformly mixing the Chinese herbal medicines, ensuring uniform proportion of various components in the composition, and adding a proper amount of solvent (water and alcohol) is beneficial to extracting the effective components of the Chinese herbal medicines, wherein the Chinese angelica, the pseudo-ginseng and the angelica dahurica have the effects of activating blood and dissolving stasis, and can improve the blood circulation disorder and inflammatory reaction caused by arthritis; the safflower and mulberry leaf herbal medicines have the effects of detumescence and pain relief, and can relieve pain and swelling; the licorice and ledebouriella root have the functions of relieving pain and inflammation, and can reduce pain and relieve inflammation.
Embodiment two:
embodiments of the present invention provide a method of using a composition for treating temporomandibular arthritis comprising the steps of:
s1, smearing the prepared composition finished product on a medicinal film with proper size, and ensuring uniform distribution of the composition;
s2, cleaning the skin of the temporomandibular joint area with warm water and a non-irritating detergent;
s3, uniformly attaching the medicinal film of the finished product of the coating composition to the temporomandibular joint area;
s4, massaging muscles around the medical film or performing hot compress around the medical film by using a hot compress article, wherein the hot compress comprises a hot water bag or a hot towel.
The temperature interval of the warm water in S2 is 38.5 ℃.
The temperature interval of hot compress in S4 is 42.5 ℃.
The grinding step in the preparation method is beneficial to smashing the Chinese herbal medicines into fine powder, improving the solubility and the release of the drug effect, the stirring step is used for uniformly mixing the Chinese herbal medicines, ensuring that the proportion of each component in the composition is uniform, adding a proper amount of solvent (water and alcohol) is beneficial to extracting the effective components of the Chinese herbal medicines, the finished product of the composition is easier to use, the smearing and applying step in the use method is beneficial to directly acting the effective components in the composition on the temporomandibular joint area, the drug effect is improved, and the warm water cleaning and hot compress steps enhance the drug absorption and relieve the arthritis symptoms through the effects of warming sensation and promoting blood circulation.
Comparative experiments on the therapeutic effects of temporomandibular arthritis composition:
analyzing the clinical curative effect of the finished composition in the treatment of temporomandibular arthritis, and mainly comprising the following steps: in 60 cases of temporomandibular arthritis patients, the non-prescription drug combination was listed as a control group according to the randomness principle in combination with different therapies, the combination treatment was listed as an example group, and the recurrence rate of inflammation and the total incidence rate of adverse reactions of the temporomandibular arthritis after 7 days of treatment were compared.
Table 1:
| recurrence rate of inflammation | Incidence of adverse reactions | |
| Basic data | 65％ | 15％ |
| Control treatment group | 70％ | 10％ |
| Group of examples | 88％ | 4％ |
The comparison of the data shows that: the clinical total effective rate of the embodiment group is better than that of the control treatment group, the adverse reaction incidence rate is lower than that of the control treatment group, the composition prepared by the embodiment of the invention is also better than that of the control treatment group in terms of inflammation recurrence rate index, the composition can avoid the side effects and dependence of medicines caused by modern technical treatment, the finished product of the composition can comprehensively condition the physical condition of patients, improve the symptoms of the temporomandibular arthritis and promote rehabilitation, and simultaneously promote blood circulation, relax tendons and activate collaterals and regulate qi and blood balance.
Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made therein without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (7)
1. The composition for treating the temporomandibular arthritis is characterized by comprising the following raw materials, by mass, 20% -40% of Chinese angelica, 10% -30% of pseudo-ginseng, 10% -20% of dahurian angelica root, 10% -20% of safflower, 5% -15% of mulberry leaf, 3% -10% of liquorice, 1% -5% of divaricate saposhnikovia root, 1% -5% of szechuan lovage rhizome, 1% -5% of Chinese ligusticum rhizome and 0.5% -2% of prepared rehmannia root;
the preparation method of the composition comprises the following method steps:
step one, preparing angelica, pseudo-ginseng, angelica dahurica, safflower, mulberry leaf, liquorice, radix sileris, ligusticum chuanxiong, ligusticum sinense and prepared rehmannia root, and ensuring the quality and purity of the Chinese herbal medicine;
grinding the Chinese angelica, the pseudo-ginseng, the angelica dahurica, the safflower, the mulberry leaf, the liquorice, the divaricate saposhnikovia root, the szechuan lovage rhizome, the ligusticum and the prepared rehmannia root;
step three, accurately weighing the weight of the Chinese herbal medicines according to the formula proportion, and filling the Chinese herbal medicines in the proportion into a container;
step four, putting the weighed Chinese herbal medicines into a container, and stirring to uniformly mix the Chinese herbal medicines;
step five, adding auxiliary materials into the mixed Chinese herbal medicines according to the requirements;
and step six, adding a proper amount of solvent comprising water and alcohol, and uniformly stirring the Chinese herbal medicine and the solvent through a stirrer or a stirring rod to ensure that the preparation of a finished product of the composition is finished.
2. The composition for treating temporomandibular arthritis according to claim 1, wherein in the second step, the grinding time of angelica, safflower, mulberry leaf and ligusticum is 1-3 min, the grinding time of notoginseng and ligusticum is 5-10 min, and the grinding time of angelica, licorice, radix sileris and prepared rehmannia root is 3-5 min.
3. The composition for treating temporomandibular arthritis according to claim 1, wherein in the fourth step, the stirring speed of angelica, angelica dahurica, safflower, mulberry leaf and ligusticum is 200-500 r/min, and the stirring speed of notoginseng, licorice, radix sileris, ligusticum wallichii and prepared rehmannia root is 500-1000 r/min.
4. The composition for treating temporomandibular arthritis according to claim 1, wherein the ratio of water to herbal medicine in the sixth step is 1:5-1:10, and the concentration of alcohol is 30% -70%.
5. A method of using a composition for the treatment of temporomandibular arthritis according to any one of claims 1 to 4, characterized in that it comprises the following steps:
s1, smearing the prepared composition finished product on a medicinal film with proper size, and ensuring uniform distribution of the composition;
s2, cleaning the skin of the temporomandibular joint area with warm water and a non-irritating detergent;
s3, uniformly attaching the medicinal film of the finished product of the coating composition to the temporomandibular joint area;
s4, massaging muscles around the medical film or performing hot compress around the medical film by using a hot compress article, wherein the hot compress comprises a hot water bag or a hot towel.
6. The method of using a composition for treating temporomandibular arthritis according to claim 5, wherein the warm water in S2 has a temperature interval of 37 to 40 ℃.
7. The method of using a composition for treating temporomandibular arthritis according to claim 5, wherein the temperature interval of the hot compress in S4 is 40-45 ℃.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311665544.5A CN117530976A (en) | 2023-12-06 | 2023-12-06 | Composition and method for treating temporomandibular arthritis |
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| CN202311665544.5A CN117530976A (en) | 2023-12-06 | 2023-12-06 | Composition and method for treating temporomandibular arthritis |
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| CN202311665544.5A Pending CN117530976A (en) | 2023-12-06 | 2023-12-06 | Composition and method for treating temporomandibular arthritis |
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| Country | Link |
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