CN117500476A - 用于清洁角蛋白材料和/或从角蛋白材料卸妆的组合物 - Google Patents
用于清洁角蛋白材料和/或从角蛋白材料卸妆的组合物 Download PDFInfo
- Publication number
- CN117500476A CN117500476A CN202180099311.6A CN202180099311A CN117500476A CN 117500476 A CN117500476 A CN 117500476A CN 202180099311 A CN202180099311 A CN 202180099311A CN 117500476 A CN117500476 A CN 117500476A
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- China
- Prior art keywords
- acid
- composition
- sodium
- group
- glutamate
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- 239000000203 mixture Substances 0.000 title claims abstract description 108
- 102000011782 Keratins Human genes 0.000 title claims abstract description 33
- 108010076876 Keratins Proteins 0.000 title claims abstract description 33
- 239000000463 material Substances 0.000 title claims abstract description 33
- 238000004140 cleaning Methods 0.000 title description 3
- 150000003839 salts Chemical class 0.000 claims abstract description 33
- 150000001413 amino acids Chemical class 0.000 claims abstract description 29
- 239000004094 surface-active agent Substances 0.000 claims abstract description 28
- 229910052751 metal Inorganic materials 0.000 claims abstract description 27
- 239000002184 metal Substances 0.000 claims abstract description 27
- 239000002738 chelating agent Substances 0.000 claims abstract description 16
- 239000008346 aqueous phase Substances 0.000 claims abstract description 11
- KXDHJXZQYSOELW-UHFFFAOYSA-N Carbamic acid Chemical class NC(O)=O KXDHJXZQYSOELW-UHFFFAOYSA-N 0.000 claims abstract description 7
- 238000002560 therapeutic procedure Methods 0.000 claims abstract description 5
- 235000001014 amino acid Nutrition 0.000 claims description 30
- 239000011734 sodium Substances 0.000 claims description 17
- 229910052708 sodium Inorganic materials 0.000 claims description 17
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 16
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims description 15
- 239000002253 acid Substances 0.000 claims description 15
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 15
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 14
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 14
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims description 10
- QPCDCPDFJACHGM-UHFFFAOYSA-N N,N-bis{2-[bis(carboxymethyl)amino]ethyl}glycine Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(=O)O)CCN(CC(O)=O)CC(O)=O QPCDCPDFJACHGM-UHFFFAOYSA-N 0.000 claims description 10
- 229910052739 hydrogen Inorganic materials 0.000 claims description 10
- 239000001257 hydrogen Substances 0.000 claims description 10
- 229960003330 pentetic acid Drugs 0.000 claims description 10
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 9
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 9
- 229910052700 potassium Inorganic materials 0.000 claims description 9
- 239000011591 potassium Substances 0.000 claims description 9
- IKGKWKGYFJBGQJ-UHFFFAOYSA-M sodium;2-(dodecanoylamino)acetate Chemical compound [Na+].CCCCCCCCCCCC(=O)NCC([O-])=O IKGKWKGYFJBGQJ-UHFFFAOYSA-M 0.000 claims description 9
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 claims description 8
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 8
- 229920005862 polyol Polymers 0.000 claims description 8
- 150000003077 polyols Chemical class 0.000 claims description 8
- 108700004121 sarkosyl Proteins 0.000 claims description 8
- 229940065859 sodium cocoyl glycinate Drugs 0.000 claims description 8
- KSAVQLQVUXSOCR-UHFFFAOYSA-M sodium lauroyl sarcosinate Chemical compound [Na+].CCCCCCCCCCCC(=O)N(C)CC([O-])=O KSAVQLQVUXSOCR-UHFFFAOYSA-M 0.000 claims description 8
- VKZRWSNIWNFCIQ-WDSKDSINSA-N (2s)-2-[2-[[(1s)-1,2-dicarboxyethyl]amino]ethylamino]butanedioic acid Chemical compound OC(=O)C[C@@H](C(O)=O)NCCN[C@H](C(O)=O)CC(O)=O VKZRWSNIWNFCIQ-WDSKDSINSA-N 0.000 claims description 7
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 7
- 229940079781 sodium cocoyl glutamate Drugs 0.000 claims description 7
- 229940045944 sodium lauroyl glutamate Drugs 0.000 claims description 7
- 229940045885 sodium lauroyl sarcosinate Drugs 0.000 claims description 7
- IWIUXJGIDSGWDN-UQKRIMTDSA-M sodium;(2s)-2-(dodecanoylamino)pentanedioate;hydron Chemical compound [Na+].CCCCCCCCCCCC(=O)N[C@H](C([O-])=O)CCC(O)=O IWIUXJGIDSGWDN-UQKRIMTDSA-M 0.000 claims description 7
- SVTBMSDMJJWYQN-UHFFFAOYSA-N 2-methylpentane-2,4-diol Chemical compound CC(O)CC(C)(C)O SVTBMSDMJJWYQN-UHFFFAOYSA-N 0.000 claims description 6
- 229940120146 EDTMP Drugs 0.000 claims description 6
- 239000011575 calcium Substances 0.000 claims description 6
- 239000010949 copper Substances 0.000 claims description 6
- PXEDJBXQKAGXNJ-QTNFYWBSSA-L disodium L-glutamate Chemical compound [Na+].[Na+].[O-]C(=O)[C@@H](N)CCC([O-])=O PXEDJBXQKAGXNJ-QTNFYWBSSA-L 0.000 claims description 6
- 229940079779 disodium cocoyl glutamate Drugs 0.000 claims description 6
- NFDRPXJGHKJRLJ-UHFFFAOYSA-N edtmp Chemical compound OP(O)(=O)CN(CP(O)(O)=O)CCN(CP(O)(O)=O)CP(O)(O)=O NFDRPXJGHKJRLJ-UHFFFAOYSA-N 0.000 claims description 6
- 235000011187 glycerol Nutrition 0.000 claims description 6
- LPUQAYUQRXPFSQ-DFWYDOINSA-M monosodium L-glutamate Chemical compound [Na+].[O-]C(=O)[C@@H](N)CCC(O)=O LPUQAYUQRXPFSQ-DFWYDOINSA-M 0.000 claims description 6
- 229940079988 potassium cocoyl glycinate Drugs 0.000 claims description 6
- 229940048081 trisodium ethylenediamine disuccinate Drugs 0.000 claims description 6
- QEHXDDFROMGLSP-VDBFCSKJSA-K trisodium;(2s)-2-[2-[[(1s)-1-carboxy-2-carboxylatoethyl]amino]ethylamino]butanedioate Chemical compound [Na+].[Na+].[Na+].OC(=O)C[C@@H](C([O-])=O)NCCN[C@H](C([O-])=O)CC([O-])=O QEHXDDFROMGLSP-VDBFCSKJSA-K 0.000 claims description 6
- TUBPSFQENHCYBW-HVDRVSQOSA-N (2s)-2-aminopentanedioic acid;2-[bis(2-hydroxyethyl)amino]ethanol Chemical compound OC(=O)[C@@H](N)CCC(O)=O.OCCN(CCO)CCO TUBPSFQENHCYBW-HVDRVSQOSA-N 0.000 claims description 5
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims description 5
- OCUCCJIRFHNWBP-IYEMJOQQSA-L Copper gluconate Chemical compound [Cu+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O OCUCCJIRFHNWBP-IYEMJOQQSA-L 0.000 claims description 5
- 150000001450 anions Chemical class 0.000 claims description 5
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 5
- 150000001768 cations Chemical class 0.000 claims description 5
- 239000001755 magnesium gluconate Substances 0.000 claims description 5
- 235000015778 magnesium gluconate Nutrition 0.000 claims description 5
- 229960003035 magnesium gluconate Drugs 0.000 claims description 5
- IAKLPCRFBAZVRW-XRDLMGPZSA-L magnesium;(2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanoate;hydrate Chemical compound O.[Mg+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O IAKLPCRFBAZVRW-XRDLMGPZSA-L 0.000 claims description 5
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 5
- 229940048912 triethanolamine cocoyl glutamate Drugs 0.000 claims description 5
- OWVLYQRCCIEOPF-QHTZZOMLSA-L zinc;(2s)-5-oxopyrrolidine-2-carboxylate Chemical compound [Zn+2].[O-]C(=O)[C@@H]1CCC(=O)N1.[O-]C(=O)[C@@H]1CCC(=O)N1 OWVLYQRCCIEOPF-QHTZZOMLSA-L 0.000 claims description 5
- CCVYRRGZDBSHFU-UHFFFAOYSA-N (2-hydroxyphenyl)acetic acid Chemical compound OC(=O)CC1=CC=CC=C1O CCVYRRGZDBSHFU-UHFFFAOYSA-N 0.000 claims description 4
- CIEZZGWIJBXOTE-UHFFFAOYSA-N 2-[bis(carboxymethyl)amino]propanoic acid Chemical compound OC(=O)C(C)N(CC(O)=O)CC(O)=O CIEZZGWIJBXOTE-UHFFFAOYSA-N 0.000 claims description 4
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 4
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims description 4
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 4
- WHMDKBIGKVEYHS-IYEMJOQQSA-L Zinc gluconate Chemical compound [Zn+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O WHMDKBIGKVEYHS-IYEMJOQQSA-L 0.000 claims description 4
- SNAAJJQQZSMGQD-UHFFFAOYSA-N aluminum magnesium Chemical compound [Mg].[Al] SNAAJJQQZSMGQD-UHFFFAOYSA-N 0.000 claims description 4
- 229910052791 calcium Inorganic materials 0.000 claims description 4
- 239000001110 calcium chloride Substances 0.000 claims description 4
- 229910001628 calcium chloride Inorganic materials 0.000 claims description 4
- 229910052802 copper Inorganic materials 0.000 claims description 4
- 229940108925 copper gluconate Drugs 0.000 claims description 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 4
- 239000011777 magnesium Substances 0.000 claims description 4
- UEGPKNKPLBYCNK-UHFFFAOYSA-L magnesium acetate Chemical compound [Mg+2].CC([O-])=O.CC([O-])=O UEGPKNKPLBYCNK-UHFFFAOYSA-L 0.000 claims description 4
- 239000011654 magnesium acetate Substances 0.000 claims description 4
- 235000011285 magnesium acetate Nutrition 0.000 claims description 4
- 229940069446 magnesium acetate Drugs 0.000 claims description 4
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 claims description 4
- 239000001095 magnesium carbonate Substances 0.000 claims description 4
- 229910000021 magnesium carbonate Inorganic materials 0.000 claims description 4
- 235000014380 magnesium carbonate Nutrition 0.000 claims description 4
- 229910052943 magnesium sulfate Inorganic materials 0.000 claims description 4
- 229960003390 magnesium sulfate Drugs 0.000 claims description 4
- 235000019341 magnesium sulphate Nutrition 0.000 claims description 4
- JQAACYUZYRBHGG-QHTZZOMLSA-L magnesium;(2s)-5-oxopyrrolidine-2-carboxylate Chemical compound [Mg+2].[O-]C(=O)[C@@H]1CCC(=O)N1.[O-]C(=O)[C@@H]1CCC(=O)N1 JQAACYUZYRBHGG-QHTZZOMLSA-L 0.000 claims description 4
- MGFYIUFZLHCRTH-UHFFFAOYSA-N nitrilotriacetic acid Chemical compound OC(=O)CN(CC(O)=O)CC(O)=O MGFYIUFZLHCRTH-UHFFFAOYSA-N 0.000 claims description 4
- 229940061605 tetrasodium glutamate diacetate Drugs 0.000 claims description 4
- UZVUJVFQFNHRSY-OUTKXMMCSA-J tetrasodium;(2s)-2-[bis(carboxylatomethyl)amino]pentanedioate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CC[C@@H](C([O-])=O)N(CC([O-])=O)CC([O-])=O UZVUJVFQFNHRSY-OUTKXMMCSA-J 0.000 claims description 4
- 239000011670 zinc gluconate Substances 0.000 claims description 4
- 235000011478 zinc gluconate Nutrition 0.000 claims description 4
- 229960000306 zinc gluconate Drugs 0.000 claims description 4
- RWLALWYNXFYRGW-UHFFFAOYSA-N 2-Ethyl-1,3-hexanediol Chemical compound CCCC(O)C(CC)CO RWLALWYNXFYRGW-UHFFFAOYSA-N 0.000 claims description 3
- GRUVVLWKPGIYEG-UHFFFAOYSA-N 2-[2-[carboxymethyl-[(2-hydroxyphenyl)methyl]amino]ethyl-[(2-hydroxyphenyl)methyl]amino]acetic acid Chemical compound C=1C=CC=C(O)C=1CN(CC(=O)O)CCN(CC(O)=O)CC1=CC=CC=C1O GRUVVLWKPGIYEG-UHFFFAOYSA-N 0.000 claims description 3
- XPFCZYUVICHKDS-UHFFFAOYSA-N 3-methylbutane-1,3-diol Chemical compound CC(C)(O)CCO XPFCZYUVICHKDS-UHFFFAOYSA-N 0.000 claims description 3
- 239000002202 Polyethylene glycol Substances 0.000 claims description 3
- 125000000217 alkyl group Chemical group 0.000 claims description 3
- 235000003704 aspartic acid Nutrition 0.000 claims description 3
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims description 3
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 claims description 3
- 229960005082 etohexadiol Drugs 0.000 claims description 3
- 229960005150 glycerol Drugs 0.000 claims description 3
- 229940051250 hexylene glycol Drugs 0.000 claims description 3
- 229960001708 magnesium carbonate Drugs 0.000 claims description 3
- 229920001223 polyethylene glycol Polymers 0.000 claims description 3
- 229920006395 saturated elastomer Polymers 0.000 claims description 3
- 229940045898 sodium stearoyl glutamate Drugs 0.000 claims description 3
- KDHFCTLPQJQDQI-BDQAORGHSA-M sodium;(4s)-4-amino-5-octadecanoyloxy-5-oxopentanoate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC(=O)OC(=O)[C@@H](N)CCC([O-])=O KDHFCTLPQJQDQI-BDQAORGHSA-M 0.000 claims description 3
- LWBVAHQZGAKXPU-BOXHHOBZSA-M sodium;(4s)-4-amino-5-octadecoxy-5-oxopentanoate Chemical compound [Na+].CCCCCCCCCCCCCCCCCCOC(=O)[C@@H](N)CCC([O-])=O LWBVAHQZGAKXPU-BOXHHOBZSA-M 0.000 claims description 3
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims description 2
- HWQVXNFIYABVIW-UHFFFAOYSA-N 2-(carboxymethylamino)-4,5-dihydroxypentanoic acid Chemical compound OCC(O)CC(C(O)=O)NCC(O)=O HWQVXNFIYABVIW-UHFFFAOYSA-N 0.000 claims description 2
- 125000004432 carbon atom Chemical group C* 0.000 claims description 2
- 125000001183 hydrocarbyl group Chemical group 0.000 claims description 2
- 229910021645 metal ion Inorganic materials 0.000 claims description 2
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 2
- 239000011701 zinc Substances 0.000 claims description 2
- DHMQDGOQFOQNFH-DYCDLGHISA-N 2-(deuterioamino)acetic acid Chemical compound [2H]NCC(O)=O DHMQDGOQFOQNFH-DYCDLGHISA-N 0.000 claims 1
- VKZRWSNIWNFCIQ-UHFFFAOYSA-N 2-[2-(1,2-dicarboxyethylamino)ethylamino]butanedioic acid Chemical compound OC(=O)CC(C(O)=O)NCCNC(C(O)=O)CC(O)=O VKZRWSNIWNFCIQ-UHFFFAOYSA-N 0.000 claims 1
- 125000006290 2-hydroxybenzyl group Chemical group [H]OC1=C(C([H])=C([H])C([H])=C1[H])C([H])([H])* 0.000 claims 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 claims 1
- IFQUWYZCAGRUJN-UHFFFAOYSA-N ethylenediaminediacetic acid Chemical compound OC(=O)CNCCNCC(O)=O IFQUWYZCAGRUJN-UHFFFAOYSA-N 0.000 claims 1
- 239000001967 plate count agar Substances 0.000 claims 1
- AGGKEGLBGGJEBZ-UHFFFAOYSA-N tetramethylenedisulfotetramine Chemical compound C1N(S2(=O)=O)CN3S(=O)(=O)N1CN2C3 AGGKEGLBGGJEBZ-UHFFFAOYSA-N 0.000 claims 1
- 238000005406 washing Methods 0.000 abstract description 2
- 229940024606 amino acid Drugs 0.000 description 25
- -1 carboxylate salt Chemical class 0.000 description 21
- 239000006260 foam Substances 0.000 description 21
- 229940009098 aspartate Drugs 0.000 description 13
- 229940083542 sodium Drugs 0.000 description 13
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 9
- 230000000052 comparative effect Effects 0.000 description 9
- 238000005187 foaming Methods 0.000 description 7
- JQAACYUZYRBHGG-UHFFFAOYSA-L magnesium pidolate Chemical compound [Mg+2].[O-]C(=O)C1CCC(=O)N1.[O-]C(=O)C1CCC(=O)N1 JQAACYUZYRBHGG-UHFFFAOYSA-L 0.000 description 7
- 239000004615 ingredient Substances 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 239000003921 oil Substances 0.000 description 6
- 235000019198 oils Nutrition 0.000 description 6
- 150000004820 halides Chemical class 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 description 4
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 4
- 108010077895 Sarcosine Proteins 0.000 description 4
- 229910052799 carbon Inorganic materials 0.000 description 4
- 235000014113 dietary fatty acids Nutrition 0.000 description 4
- KCIDZIIHRGYJAE-YGFYJFDDSA-L dipotassium;[(2r,3r,4s,5r,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] phosphate Chemical compound [K+].[K+].OC[C@H]1O[C@H](OP([O-])([O-])=O)[C@H](O)[C@@H](O)[C@H]1O KCIDZIIHRGYJAE-YGFYJFDDSA-L 0.000 description 4
- 239000000194 fatty acid Substances 0.000 description 4
- 229930195729 fatty acid Natural products 0.000 description 4
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 4
- 150000007524 organic acids Chemical class 0.000 description 4
- FSYKKLYZXJSNPZ-UHFFFAOYSA-N sarcosine Chemical compound C[NH2+]CC([O-])=O FSYKKLYZXJSNPZ-UHFFFAOYSA-N 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 3
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 3
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 3
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 description 3
- 229940000635 beta-alanine Drugs 0.000 description 3
- UCMIRNVEIXFBKS-UHFFFAOYSA-N beta-aminopropionic acid Natural products NCCC(O)=O UCMIRNVEIXFBKS-UHFFFAOYSA-N 0.000 description 3
- 235000015165 citric acid Nutrition 0.000 description 3
- 229940108928 copper Drugs 0.000 description 3
- 239000002537 cosmetic Substances 0.000 description 3
- 150000004665 fatty acids Chemical class 0.000 description 3
- 239000000499 gel Substances 0.000 description 3
- 230000014509 gene expression Effects 0.000 description 3
- 229940070808 lauroyl aspartate Drugs 0.000 description 3
- 150000007522 mineralic acids Chemical class 0.000 description 3
- 125000001419 myristoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 3
- CXMXRPHRNRROMY-UHFFFAOYSA-N sebacic acid Chemical compound OC(=O)CCCCCCCCC(O)=O CXMXRPHRNRROMY-UHFFFAOYSA-N 0.000 description 3
- PQHYOGIRXOKOEJ-UHFFFAOYSA-N 2-(1,2-dicarboxyethylamino)butanedioic acid Chemical compound OC(=O)CC(C(O)=O)NC(C(O)=O)CC(O)=O PQHYOGIRXOKOEJ-UHFFFAOYSA-N 0.000 description 2
- UNWFFCPRJXMCNV-UHFFFAOYSA-N 3-[dodecanoyl(methyl)amino]propanoic acid Chemical compound CCCCCCCCCCCC(=O)N(C)CCC(O)=O UNWFFCPRJXMCNV-UHFFFAOYSA-N 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 2
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 2
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- GVALZJMUIHGIMD-UHFFFAOYSA-H magnesium phosphate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O GVALZJMUIHGIMD-UHFFFAOYSA-H 0.000 description 1
- 239000004137 magnesium phosphate Substances 0.000 description 1
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- 238000002360 preparation method Methods 0.000 description 1
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- 150000003892 tartrate salts Chemical class 0.000 description 1
- LPWCRLGKYWVLHQ-UHFFFAOYSA-N tetradecanoyl chloride Chemical compound CCCCCCCCCCCCCC(Cl)=O LPWCRLGKYWVLHQ-UHFFFAOYSA-N 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- HFRXJVQOXRXOPP-UHFFFAOYSA-N thionyl bromide Chemical compound BrS(Br)=O HFRXJVQOXRXOPP-UHFFFAOYSA-N 0.000 description 1
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- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
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- 235000005074 zinc chloride Nutrition 0.000 description 1
- 239000011746 zinc citrate Substances 0.000 description 1
- 235000006076 zinc citrate Nutrition 0.000 description 1
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- 229910000165 zinc phosphate Inorganic materials 0.000 description 1
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
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- PCHQDTOLHOFHHK-UHFFFAOYSA-L zinc;hydrogen carbonate Chemical compound [Zn+2].OC([O-])=O.OC([O-])=O PCHQDTOLHOFHHK-UHFFFAOYSA-L 0.000 description 1
Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/27—Zinc; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
- A61Q1/14—Preparations for removing make-up
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/51—Chelating agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Cosmetics (AREA)
- Detergent Compositions (AREA)
Abstract
用于清洁角蛋白材料和/或从角蛋白材料卸妆的组合物，其在水相中包含：a)至少一种氨基酸表面活性剂；b)至少一种选自氨基羧酸及其盐的螯合剂；和c)至少一种二价金属盐。用于清洁角蛋白材料(尤其皮肤)和/或从角蛋白材料(尤其皮肤)卸妆的非治疗性方法，其包括将组合物施用到角蛋白材料(尤其皮肤)，以及在随意的时间段之后洗去所述组合物。
Description
技术领域
本发明涉及化妆品组合物，尤其用于清洁角蛋白材料和/或从角蛋白材料卸妆的组合物。本发明还涉及使用所述组合物清洁角蛋白材料和/或从角蛋白材料卸妆的非治疗性方法。
背景技术
清洁皮肤或从皮肤卸妆对于护理皮肤是非常重要的。其必须尽可能地有效，因为油腻的残留物(例如过量的皮脂)、日常使用的化妆产品和彩妆产品(尤其防水产品)的残余物积聚在皮肤褶皱中，并且可堵塞皮肤的毛孔以及导致斑点的出现。
已知若干类型的皮肤清洁或卸妆产品，例如可冲洗的无水油和凝胶、发泡霜(foaming creams)和乳液。
可冲洗的无水油和凝胶凭借存在于这些配制品中的油而具有清洁或卸妆作用。这些油使得有可能溶解脂肪残余物和分散彩妆颜料。这些产品是有效且良好耐受的。
但是，它们表现出厚重、不发泡和在施用时不赋予良好的皮肤修饰(skin finish)的缺点，这从化妆品的角度来看是不利的。
另一方面，发泡霜、乳液和凝胶凭借表面活性剂而具有清洁或卸妆作用，所述表面活性剂使脂肪残余物悬浮在面部上。由于泡沫并且容易将它们去除，它们是有效的并且使用起来愉悦。
泡沫性质对于发泡清洁剂而言非常重要。但是，一些发泡清洁剂在泡沫密度方面不令人满意。
为了在含有氨基酸表面活性剂的发泡清洁剂中具有更好的泡沫密度，传统方法可包括更多的表面活性剂或更多的聚合物。但是，这些方法会提高配制成本或带来不期望的洗去感觉和皮肤修饰。
因此，需要提供改善泡沫密度的另一种解决方案。
发明概述
发明人已经发现，可以通过本发明来实现此类需求。
由此，根据一个方面，本发明提供了用于清洁角蛋白材料和/或从角蛋白材料卸妆的组合物，其在水相中包含：
a)至少一种氨基酸表面活性剂；
b)至少一种选自氨基羧酸及其盐的螯合剂；和
c)至少一种二价金属盐。
根据本发明的组合物可以提供良好的泡沫密度。
其可用作日常的洁面剂或卸妆剂。本发明组合物是洗去型产品。因此，可将此类组合物施用在皮肤(即，面部和/或身体)上，并且随后用冲洗水冲洗。
根据另一个方面，本发明提供了用于清洁角蛋白材料(尤其皮肤)和/或从角蛋白材料(尤其皮肤)卸妆的非治疗性方法，其包括将根据本发明的组合物施用到角蛋白材料(尤其皮肤)，以及在随意的时间段之后洗去所述组合物。
本发明的其它主题和特性、方面和优点将在阅读以下描述和实施例时甚至更加清楚地显现。
发明详述
除非另行定义，否则本文使用的所有技术和科学术语具有与本发明所属领域的技术人员所通常理解的相同的含义。当术语在本说明书中的定义与本发明所属领域的技术人员所通常理解的含义冲突时，应适用本文所描述的定义。
在下文中，并且除非另行指明，否则值的范围的上下限包括在该范围内，在表述“介于……之间”和“……至……”中尤其如此。
此外，本说明书中使用的表述“至少一个/种”等同于表述“一个/种或更多个/种”。
在本申请通篇中，术语“包含/括”应解释为涵盖所有具体提及的特征以及任选的、附加的、未指明的特征。如本文所使用的，术语“包含/括”的使用也公开了其中不存在具体提及的特征以外的特征的实施方案(即，“由……组成”)。
除非另行指明，否则说明书和权利要求书中使用的表示成分的量等等的所有数值应理解为被术语“约”修饰。因此，除非相反地指出，否则本文描述的数值和参数是能够根据所需目的视需要变化的近似值。
出于本发明的目的，术语“角蛋白材料”意欲涵盖人的皮肤、粘膜(例如嘴唇)。根据本发明最特别考虑面部皮肤。
除非另行指明，否则本发明中的所有百分比指重量百分比。
根据一个方面，本发明涉及用于清洁角蛋白材料和/或从角蛋白材料卸妆的组合物，其在水相中包含：
a)至少一种氨基酸表面活性剂；
b)至少一种选自氨基羧酸及其盐的螯合剂；和
c)至少一种二价金属盐。
氨基酸表面活性剂
根据本发明的组合物包含至少一种氨基酸表面活性剂。
在一个实施方案中，所述氨基酸表面活性剂衍生自氨基酸的羧酸盐，其中位于氨基酸盐的α-碳或β-碳上的氨基经C8-C22脂肪酸衍生物酰化。
可通过常规方式，例如通过用碱中和相应的氨基酸来形成这些氨基酸的羧酸盐。位于中和的氨基酸的α-碳或β-碳上的氨基经由众所周知的肖顿-鲍曼(Schotten-Baumann)反应在碱的存在下被脂肪酸卤化物(酰卤)酰化，得到酰胺，由此形成所需的表面活性剂反应产物，即，氨基酸表面活性剂。用于氨基酸羧酸盐的酰化的合适酰卤包括酰氯、酰溴、酰氟和酰碘。可通过使饱和或不饱和的直链或支链C8-C22脂肪酸与亚硫酰卤(亚硫酰溴、亚硫酰氯、亚硫酰氟和亚硫酰碘)反应来制备酰卤。代表性的酰卤包括但不限于选自以下各项的酰氯：癸酰氯、十二烷酰氯(月桂酰氯)、椰油酰氯(椰子油得到的脂肪酸氯化物)、十四烷酰氯(肉豆蔻酰氯)、十六烷酰氯(棕榈酰氯)、十八烷酰氯(硬脂酰氯)、9-十八碳烯酰氯(octadecenoyl chloride)(油酰氯)、二十烷酰氯(花生酰氯)、二十二烷酰氯(山萮酰氯)、及其任何混合物。其它的酰卤包括前述脂肪酸的溴化物、氟化物和碘化物。在2008年8月21日公开的美国专利申请公开第2008/0200704号(通过引用将所述申请并入本文)中阐述了用于制备酰卤的方法以及用于酰化氨基酸的替代性方法。
优选地，所述氨基酸表面活性剂由式(I)代表：
其中：
Z代表具有8至22个碳原子的饱和或不饱和的、直链或支链的烃基，
X是氢或甲基，
n是0或1，
Y选自氢、-CH3、-CH(CH3)2、-CH2CH(CH3)2、-CH(CH3)CH2CH3、-CH2C6H5、-CH2C2H4OH、-CH2OH、-CH(OH)CH3、-(CH2)4NH2、-(CH2)3NHC(NH)NH2、-CH2C(O)O-M+、-(CH2)2C(O)OH、-(CH2)2C(O)O-M+，且
M是其中COO是抗衡阴离子的成盐阳离子，例如钠、钾、铵或三乙醇胺。
在一个实施方案中，在式(I)中：
Z代表直链或支链C8-C22烷基，
X是氢或甲基，
n是0，
Y选自氢、-(CH2)2C(O)OH、-(CH2)2C(O)O-M+，且
M是其中COO是抗衡阴离子的成盐阳离子，例如钠、钾、铵或三乙醇胺。
根据本发明的一个优选实施方案，在式(I)中：
Z代表直链或支链C8-C22烷基，
X是氢或甲基，
n是0，
Y选自氢、-(CH2)2C(O)OH、-(CH2)2C(O)O-M+，且
M是其中COO是抗衡阴离子的成盐阳离子，例如钠、钾、铵或三乙醇胺。
氨基酸表面活性剂的实例是以下各项的盐及其任何混合物：丙氨酸、精氨酸、天冬氨酸、谷氨酸、甘氨酸、异亮氨酸、亮氨酸、赖氨酸、苯丙氨酸、丝氨酸、酪氨酸、缬氨酸、肌氨酸。更具体地，可以提及例如以下的氨基酸表面活性剂：辛酰谷氨酸二钾、十一碳烯酰谷氨酸二钾、辛酰谷氨酸二钠、椰油酰谷氨酸二钠、月桂酰谷氨酸二钠、硬脂酰谷氨酸二钠、十一碳烯酰谷氨酸二钠、辛酰谷氨酸钾、椰油酰谷氨酸钾、月桂酰谷氨酸钾、肉豆蔻酰谷氨酸钾、硬脂酰谷氨酸钾、十一碳烯酰谷氨酸钾、辛酰谷氨酸钠、椰油酰谷氨酸钠、月桂酰谷氨酸钠、肉豆蔻酰谷氨酸钠、橄榄油酰谷氨酸钠、棕榈酰谷氨酸钠、硬脂酰谷氨酸钠、十一碳烯酰谷氨酸钠、椰油酰甲基β-丙氨酸盐、月桂酰β-丙氨酸盐、月桂酰甲基β-丙氨酸盐、肉豆蔻酰β-丙氨酸盐、月桂酰甲基β-丙氨酸钾、椰油酰丙氨酸钠、椰油酰甲基β-丙氨酸钠和肉豆蔻酰甲基β-丙氨酸钠、棕榈酰甘氨酸盐、月桂酰甘氨酸钠、椰油酰甘氨酸钠、肉豆蔻酰甘氨酸钠、月桂酰甘氨酸钾、椰油酰甘氨酸钾、月桂酰肌氨酸钾、椰油酰肌氨酸钾、椰油酰肌氨酸钠、月桂酰肌氨酸钠、肉豆蔻酰肌氨酸钠、油酰肌氨酸钠、棕榈酰肌氨酸钠、月桂酰肌氨酸铵、月桂酰天冬氨酸钠、肉豆蔻酰天冬氨酸钠、椰油酰天冬氨酸钠、己酰天冬氨酸钠、月桂酰天冬氨酸二钠、肉豆蔻酰天冬氨酸二钠、椰油酰天冬氨酸二钠、己酰天冬氨酸二钠、月桂酰天冬氨酸钾、肉豆蔻酰天冬氨酸钾、椰油酰天冬氨酸钾、己酰天冬氨酸钾、月桂酰天冬氨酸二钾、肉豆蔻酰天冬氨酸二钾、椰油酰天冬氨酸二钾、己酰天冬氨酸二钾、及其混合物。
市售氨基酸表面活性剂可以提及例如酰基肌氨酸盐，例如由Ciba公司以名称SarkosylNL出售的月桂酰肌氨酸钠或由SEPPIC公司以名称Oramix L/>出售的月桂酰肌氨酸钠、由Nikkol公司以名称Nikkol Sarcosinate/>出售的肉豆蔻酰肌氨酸钠、或由Nikkol公司以名称Nikkol Sarcosinate/>出售的棕榈酰肌氨酸钠；丙氨酸盐，例如由Nikkol公司以名称Sodium Nikkol Alaninate LN/>出售的N-月桂酰基-N-甲基酰胺基丙酸钠或由Kawaken公司以名称Alanone/>出售的N-月桂酰基-N-甲基酰胺基丙酸钠、以及由Kawaken公司以名称Alanone/>出售的N-月桂酰基-N-甲基丙氨酸三乙醇胺；N-酰基谷氨酸盐，例如由Ajinomoto公司以名称Acylglutamate CT-/>出售的单椰油酰谷氨酸三乙醇胺和由Ajinomoto公司以名称Acylglutamate LT-/>出售的月桂酰谷氨酸三乙醇胺；甘氨酸盐，例如由Ajinomoto公司以名称Amilite GCS-/>出售的N-椰油酰甘氨酸钠；天冬氨酸盐，例如由Mitsubishi公司以名称/>出售的N-月桂酰天冬氨酸三乙醇胺与N-肉豆蔻酰天冬氨酸三乙醇胺的混合物；柠檬酸盐；及其任何混合物。
根据本发明，优选的氨基酸表面活性剂选自月桂酰肌氨酸钠、椰油酰甘氨酸钠、椰油酰谷氨酸钠、硬脂酰谷氨酸钠、椰油酰谷氨酸二钠、月桂酰谷氨酸钠、椰油酰甘氨酸钾、椰油酰谷氨酸三乙醇胺、或其混合物。
市售的在该组合物中的优选氨基酸表面活性剂可以提及月桂酰肌氨酸钠(由Seppic出售的ORAMIX L 30)、椰油酰甘氨酸钠(和)水(由Ajinomoto出售的GCS-12K)、椰油酰谷氨酸钠(和)椰油酰谷氨酸二钠(由Ajinomoto出售的/>CS-22)、以及月桂酰谷氨酸钠(由Ajinomoto出售的/>LS-11)。
根据一个优选实施方案，氨基酸表面活性剂选自月桂酰肌氨酸钠、椰油酰甘氨酸钠、椰油酰谷氨酸钠、硬脂酰谷氨酸钠、椰油酰谷氨酸二钠、月桂酰谷氨酸钠、椰油酰甘氨酸钾、椰油酰谷氨酸三乙醇胺、及其混合物。
由于使用氨基酸表面活性剂，因此根据本发明的组合物不对角蛋白材料产生刺激。
有利地，相对于根据本发明的组合物的总重量计，氨基酸表面活性剂以范围为1重量％至60重量％、优选20重量％至50重量％、更优选35重量％至45重量％的量存在于该组合物中。
螯合剂
根据本发明的组合物包含至少一种螯合剂，其选自氨基羧酸及其盐。
该盐特别是碱金属盐、碱土金属盐、铵盐和取代铵盐。
螯合剂可尤其选自具有以下INCI名称的化合物：
二亚乙基三胺五乙酸(DTPA)，
乙二胺二琥珀酸(EDDS)和乙二胺二琥珀酸三钠，例如来自INNOSPEC ACTIVECHEMICALS的Octaquest E30，
乙二胺四乙酸(EDTA)，
乙二胺-N,N'-二戊二酸(EDDG)，
甘氨酰胺-N,N'-二琥珀酸(GADS)，
2-羟基丙二胺-N,N'-二琥珀酸(HPDDS)，
乙二胺-N,N'-双(邻羟基苯乙酸)(EDDHA)，
N,N'-双(2-羟苄基)乙二胺-N,N'-二乙酸(HBED)，
次氮基三乙酸(NTA)，
甲基甘氨酸二乙酸(MGDA)，
N-2-羟乙基-N,N-二乙酸和甘油基亚氨基二乙酸(如文献EP-A-317542和EP-A-399133中所描述)，
亚氨基二乙酸-N-2-羟丙基磺酸和天冬氨酸N-羧甲基N-2-羟丙基-3-磺酸(如EP-A-516102中所描述)，
β-丙氨酸-N,N'-二乙酸、天冬氨酸-N,N'-二乙酸和天冬氨酸-N-单乙酸(描述于EP-A-509382中)，
基于亚氨基二琥珀酸(IDSA)的螯合剂(如EP-A-509382中所描述)，
乙醇二甘氨酸，和
谷氨酸二乙酸四钠(GLDA)，如来自Akzo Nobel的Dissolvine GL38或45S。
在所提及的螯合剂之中，优选使用乙二胺四乙酸(EDTA)、二亚乙基三胺五乙酸(DTPA)、S,S'-乙二胺二琥珀酸(EDDS)、乙二胺二琥珀酸三钠、乙二胺四亚甲基膦酸(EDTMP)和谷氨酸二乙酸四钠(GLDA)、及其混合物。
有利地，相对于该组合物的总重量计，螯合剂以范围为0.05重量％至5重量％、优选0.1重量％至1重量％、更优选0.2重量％至0.4重量％的量存在。
金属盐
根据本发明的组合物包含至少一种二价金属盐。
二价金属盐和/或三价金属盐包含金属离子M12+。优选地，M12+选自Mg2+、Ca2+、Zn2+、Fe2+、Mn2+和Cu2+。
金属盐选自有机酸或无机酸的金属盐。
作为有机酸的实例，可以提及抗坏血酸、甲酸、乙酸、乙醇酸、葡糖酸、乳酸、扁桃酸、草酸、马来酸、丙二酸、乙醛酸、琥珀酸、己二酸、富马酸、癸二酸、柠檬酸、酒石酸、苹果酸、三羧酸、戊二酸、葡糖二酸、吡咯烷酮羧酸、苯酚磺酸、水杨酸等。
作为无机酸的实例，可以提及硫酸、碳酸、硅酸、盐酸、硝酸、磷酸等。
优选地，无机酸的金属盐选自金属的氯化物、硫酸盐、硝酸盐、碳酸盐和碳酸氢盐、磷酸盐、硅酸盐及其混合物，其中金属选自Mg、Ca、Zn、Mn、Cu和Fe。
更优选地，无机酸的金属盐选自氯化钙、硫酸钙、硝酸钙、碳酸钙和碳酸氢钙、磷酸钙、氯化锌、硫酸锌、硝酸锌、碳酸锌和碳酸氢锌、磷酸锌、氯化镁、硫酸镁、硝酸镁、碳酸镁和碳酸氢镁、磷酸镁、硅酸镁铝及其混合物。
优选地，有机酸的金属盐选自金属的抗坏血酸盐、甲酸盐、乙酸盐、乙醇酸盐、葡糖酸盐、乳酸盐、扁桃酸盐、草酸盐、马来酸盐、丙二酸盐、乙醛酸盐、琥珀酸盐、己二酸盐、富马酸盐、癸二酸盐、柠檬酸盐、酒石酸盐、苹果酸盐、三羧酸盐、戊二酸盐、葡糖二酸盐、吡咯烷酮羧酸盐、苯酚磺酸盐、水杨酸盐、及其混合物，其中金属选自Mg、Ca、Zn、Mn、Cu和Fe。
更优选地，有机酸的金属盐选自葡糖酸镁、PCA镁(吡咯烷酮羧酸镁)、乙酸镁、PCA钙(吡咯烷酮羧酸钙)、乳酸锌、葡糖酸锌、苯酚磺酸锌、水杨酸锌、PCA锌(吡咯烷酮羧酸锌)、柠檬酸锌、抗坏血酸锌、PCA铜(吡咯烷酮羧酸铜)、葡糖酸铜及其混合物。
根据一个优选实施方案，金属盐选自葡糖酸镁、PCA镁、硫酸镁、乙酸镁、碳酸镁、硅酸镁铝、碳酸钙、PCA钙、氯化钙、碳酸钙、PCA锌、葡糖酸锌、PCA铜、葡糖酸铜及其混合物。
有利地，相对于根据本发明的组合物的总重量计，金属盐以范围为0.1重量％至5重量％、优选0.3重量％至3重量％、更优选0.5重量％至1重量％的量存在于该组合物中。
水相
本发明组合物包含至少一个水相。
根据一个优选实施方案，本发明组合物为水性糊状物。
根据本发明的组合物的水相包含水和任选的一种或更多种水混溶性或至少部分水混溶性的化合物，例如C2-C8多元醇或一元醇，例如乙醇和异丙醇。
术语“多元醇”应理解为表示包含至少两个游离羟基的任何有机分子。可提及的多元醇的实例包括二元醇，例如丁二醇、丙二醇、一缩二丙二醇、异戊二醇、己二醇、辛乙二醇、丙三醇(即，甘油)和聚乙二醇。
根据一个优选实施方案，根据本申请的组合物进一步包含至少一种C2-C8多元醇，其选自丁二醇、丙二醇、一缩二丙二醇、异戊二醇、己二醇、辛乙二醇、甘油和聚乙二醇。更优选地，C2-C8多元醇是甘油。
优选地，相对于组合物的总重量计，C2-C8多元醇以范围为1重量％至70重量％、优选30重量％至40重量％的量存在。
相对于组合物的总重量计，水相可以占40重量％至70重量％、优选45重量％至65重量％。
附加成分
根据本发明的组合物可包含一种或更多种附加成分，其选自皮肤清洁剂中常规使用的那些。
按照本发明的组合物可以包含任何以下添加剂：pH调节剂(例如柠檬酸)；附加表面活性剂；生物提取物；抗菌剂、芳香剂；增稠剂(例如丙烯酸酯共聚物)；结构化试剂(例如氯化钾、鲸蜡醇)和阳离子防腐剂。
本领域技术人员可以凭借常规操作来调节根据本发明的组合物中存在的附加成分的类型和量，以致这些组合物的所需性质不受附加成分的不利影响。
根据一个优选实施方案，本发明涉及用于清洁角蛋白材料和/或从角蛋白材料卸妆的组合物，相对于该组合物的总重量计，其在水相中包含：
a)35重量％至45重量％的至少一种氨基酸表面活性剂，其选自月桂酰肌氨酸钠、椰油酰甘氨酸钠、椰油酰谷氨酸钠、硬脂酰谷氨酸钠、椰油酰谷氨酸二钠、月桂酰谷氨酸钠、椰油酰甘氨酸钾、椰油酰谷氨酸三乙醇胺及其混合物；
b)0.2重量％至0.4重量％的至少一种螯合剂，其选自乙二胺四乙酸(EDTA)、二亚乙基三胺五乙酸(DTPA)、S,S'-乙二胺二琥珀酸(EDDS)、乙二胺二琥珀酸三钠、乙二胺四亚甲基膦酸(EDTMP)和谷氨酸二乙酸四钠(GLDA)及其混合物；和
c)0.5重量％至1重量％的至少一种二价金属盐，其选自葡糖酸镁、PCA镁、硫酸镁、乙酸镁、碳酸镁、硅酸镁铝、碳酸钙、PCA钙、氯化钙、碳酸钙、PCA锌、葡糖酸锌、PCA铜、葡糖酸铜及其混合物。
根据本发明的组合物可包含油。优选地，根据本发明的组合物不包含任何油。
方法和用途
可通过施用到角蛋白材料而在用于清洁角蛋白材料(例如皮肤，尤其面部)和/或从角蛋白材料(例如皮肤，尤其面部)卸妆的方法中使用根据本发明的组合物。
根据本发明的组合物可以是结晶体系，其呈糊状物、霜或凝胶质地的乳液的形式。
发现根据本发明的组合物可以提供良好的泡沫密度。
根据本发明的组合物可以通过任何使得能够实现均匀分布的方式(尤其使用手指或棉球)而施用，并且可以通过用水冲洗而去除。
因此，根据另一个方面，本发明涉及用于清洁角蛋白材料(尤其皮肤)和/或从角蛋白材料(尤其皮肤)卸妆的非治疗性方法，其包括将根据本发明的组合物施用到角蛋白材料(尤其皮肤)，以及在随意的时间段之后洗去所述组合物。
通过作为非限制性示例给出的以下描述的实施例更详细地例示本发明
实施例
在表1中列举了所使用的主要原材料、其商品名和供应商。
表1
发明例1-4和对比例1-4
制备包含表2中显示的成分的发明例(IE)1-4的组合物和对比例(CE)1-4的组合物，其中所有的量由相对于各组合物的总重量计的活性物质的重量百分比来表示。
表2
发明例1-4的组合物属于本发明。
对比例1的组合物不包含任何二价金属盐。
对比例2的组合物不包含选自氨基羧酸及其盐的任何螯合剂。
对比例3的组合物不包含任何二价金属盐。
对比例4的组合物不包含任何二价金属盐和选自氨基羧酸及其盐的螯合剂。
制备方法
以发明例1的组合物为例，如下制备组合物：
将甘油和椰油酰甘氨酸钠加入主烧杯中，随后在搅拌下加入丙烯酸酯共聚物并加热至70-85℃。接下来，依次加入葡糖酸镁、乙二胺二琥珀酸三钠和氯化钾。接下来，在高于70℃的温度下加入柠檬酸和鲸蜡醇，随后加入水，以获得组合物。将组合物冷却至30℃并老化24小时。
发现对于对比例2的组合物，大多数二价盐将与氨基酸表面活性剂一起变成晶体。
组合物的评估
对所制备的组合物评估其泡沫密度。
泡沫密度
通过观察经由双手产生的泡沫来如下评估泡沫密度。
程序：
1)润湿戴有丁腈手套的双手，并将0.5克待测试的组合物施用到手套上；
2)用双掌摩擦组合物60圈(2圈/秒)；和
3)将所有泡沫一起放在一只手掌中。
图1显示了泡沫密度测试中由发明例1的组合物产生的泡沫。
图2显示了泡沫密度测试中由对比例4的组合物产生的泡沫。
给出1-15的范围内的评分，其中1-4表示低泡沫密度，5-9表示中等泡沫密度，且10-15表示高泡沫密度。
所获得的结果总结在表3中。
| 性质 | IE.1 | IE.2 | IE.3 | IE.4 | CE.1 | CE.2 | CE.3 | CE.4 |
| 泡沫密度 | 12 | 11 | 14 | 13 | 5 | 9 | 6 | 5 |
从表3可以看出，与对比例1-4的组合物相比，发明例1-4的组合物显示更好的泡沫密度。
还发现，发明例1-4的组合物在4℃和45℃的温度下2个月没有明显的外观变化。
Claims (13)
1.用于清洁角蛋白材料和/或从角蛋白材料卸妆的组合物，其在水相中包含：
a)至少一种氨基酸表面活性剂；
b)至少一种选自氨基羧酸及其盐的螯合剂；和
c)至少一种二价金属盐。
2.根据权利要求1所述的组合物，其中所述氨基酸表面活性剂由式(I)代表：
其中：
Z代表具有8至22个碳原子的饱和或不饱和的、直链或支链烃基，
X是氢或甲基，
n是0或1，
Y选自氢、-CH3、-CH(CH3)2、-CH2CH(CH3)2、-CH(CH3)CH2CH3、-CH2C6H5、-CH2C2H4OH、-CH2OH、-CH(OH)CH3、-(CH2)4NH2、-(CH2)3NHC(NH)NH2、-CH2C(O)O-M+、-(CH2)2C(O)OH、-(CH2)2C(O)O-M+，且
M是其中COO是抗衡阴离子的成盐阳离子，例如钠、钾、铵或三乙醇胺，
优选地，在式(I)中：
Z代表直链或支链C8-C22烷基，
X是氢或甲基，
n是0，
Y选自氢、-(CH2)2C(O)OH、-(CH2)2C(O)O-M+，且
M是其中COO是抗衡阴离子的成盐阳离子，例如钠、钾、铵或三乙醇胺。
3.根据权利要求1或2所述的组合物，其中所述氨基酸表面活性剂选自月桂酰肌氨酸钠、椰油酰甘氨酸钠、椰油酰谷氨酸钠、硬脂酰谷氨酸钠、椰油酰谷氨酸二钠、月桂酰谷氨酸钠、椰油酰甘氨酸钾、椰油酰谷氨酸三乙醇胺、及其混合物。
4.根据权利要求1至3中任一项所述的组合物，其中相对于所述组合物的总重量计，所述氨基酸表面活性剂以范围为1重量％至60重量％、优选20重量％至50重量％、更优选35重量％至45重量％的量存在。
5.根据权利要求1至4中任一项所述的组合物，其中所述螯合剂选自二亚乙基三胺五乙酸(DTPA)、乙二胺二琥珀酸(EDDS)、乙二胺二琥珀酸三钠、乙二胺四乙酸(EDTA)、乙二胺-N,N'-二戊二酸(EDDG)、甘氨酰胺-N,N'-二琥珀酸(GADS)、2-羟基丙二胺-N,N'-二琥珀酸(HPDDS)、乙二胺-N,N'-双(邻羟基苯乙酸)(EDDHA)、N,N'-双(2-羟苄基)乙二胺-N,N'-二乙酸(HBED)、次氮基三乙酸(NTA)、甲基甘氨酸二乙酸(MGDA)、N-2-羟乙基-N,N-二乙酸、甘油基亚氨基二乙酸、亚氨基二乙酸-N-2-羟丙基磺酸、天冬氨酸N-羧甲基N-2-羟丙基-3-磺酸、β-丙氨酸-N,N'-二乙酸、天冬氨酸-N,N'-二乙酸、天冬氨酸-N-单乙酸、基于亚氨基二琥珀酸(IDSA)的螯合剂、乙醇二甘氨酸和谷氨酸二乙酸四钠(GLDA)。
6.根据权利要求1至5中任一项所述的组合物，其中相对于所述组合物的总重量计，所述螯合剂以范围为0.05重量％至5重量％、优选0.1重量％至1重量％、更优选0.2重量％至0.4重量％的含量存在。
7.根据权利要求1至6中任一项所述的组合物，其中所述二价金属盐包含金属离子M12+，其选自Mg2+、Ca2+、Zn2+、Fe2+、Mn2+和Cu2+。
8.根据权利要求1至7中任一项所述的组合物，其中相对于所述组合物的总重量计，所述二价金属盐以范围为0.1重量％至5重量％、优选0.3重量％至3重量％、更优选0.5重量％至1重量％的量存在。
9.根据权利要求1至8中任一项所述的组合物，其进一步包含至少一种C2-C8多元醇，其选自丁二醇、丙二醇、一缩二丙二醇、异戊二醇、己二醇、辛乙二醇、甘油和聚乙二醇。
10.根据权利要求9所述的组合物，其中相对于所述组合物的总重量计，所述C2-C8多元醇以范围为1重量％至70重量％、优选30重量％至40重量％的量存在。
11.根据权利要求1至10中任一项所述的组合物，其中相对于所述组合物的总重量计，所述水相占40重量％至70重量％、优选45重量％至65重量％。
12.根据权利要求1所述的组合物，相对于所述组合物的总重量计，其在水相中包含：
a)35重量％至45重量％的至少一种氨基酸表面活性剂，其选自月桂酰肌氨酸钠、椰油酰甘氨酸钠、椰油酰谷氨酸钠、硬脂酰谷氨酸钠、椰油酰谷氨酸二钠、月桂酰谷氨酸钠、椰油酰甘氨酸钾、椰油酰谷氨酸三乙醇胺、及其混合物；
b)0.2重量％至0.4重量％的至少一种螯合剂，其选自乙二胺四乙酸(EDTA)、二亚乙基三胺五乙酸(DTPA)、S,S'-乙二胺二琥珀酸(EDDS)、乙二胺二琥珀酸三钠、乙二胺四亚甲基膦酸(EDTMP)和谷氨酸二乙酸四钠(GLDA)、及其混合物；和
c)0.5重量％至1重量％的至少一种二价金属盐，其选自葡糖酸镁、PCA镁、硫酸镁、乙酸镁、碳酸镁、硅酸镁铝、碳酸钙、PCA钙、氯化钙、碳酸钙、PCA锌、葡糖酸锌、PCA铜、葡糖酸铜、及其混合物。
13.用于清洁角蛋白材料尤其皮肤和/或从角蛋白材料尤其皮肤卸妆的非治疗性方法，其包括将根据权利要求1至12中任一项所述的组合物施用到角蛋白材料尤其皮肤，以及在随意的时间段之后洗去所述组合物。
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| GB8726673D0 (en) | 1987-11-13 | 1987-12-16 | Procter & Gamble | Hard-surface cleaning compositions |
| EP0399133B1 (en) | 1989-05-23 | 1994-03-09 | The Procter & Gamble Company | Detergent and cleaning compositions containing chelating agents |
| US5362412A (en) | 1991-04-17 | 1994-11-08 | Hampshire Chemical Corp. | Biodegradable bleach stabilizers for detergents |
| US5208369A (en) | 1991-05-31 | 1993-05-04 | The Dow Chemical Company | Degradable chelants having sulfonate groups, uses and compositions thereof |
| GB9204175D0 (en) * | 1992-02-27 | 1992-04-08 | Unilever Plc | Cleansing composition |
| GB2288812B (en) * | 1994-04-26 | 1998-08-26 | Procter & Gamble | Cleansing compositions |
| FR2813189B1 (fr) * | 2000-08-31 | 2003-02-28 | Oreal | Creme cosmetique moussante pour le traitement des peaux grasses |
| FR2814071A1 (fr) * | 2000-09-21 | 2002-03-22 | Oreal | Composition a base de glycoglyceride et ses utilisations notamment cosmetiques |
| KR101045901B1 (ko) * | 2004-02-13 | 2011-07-01 | 아지노모토 가부시키가이샤 | 증점 조성물 |
| JP5591436B2 (ja) * | 2006-07-07 | 2014-09-17 | 味の素株式会社 | 低温安定クリーム状洗浄剤組成物 |
| FR2980691B1 (fr) * | 2011-09-30 | 2014-03-14 | Galderma Sa | Composition de lavage |
| CN103923761A (zh) * | 2014-04-25 | 2014-07-16 | 湖州华鼎贸易有限公司 | 一种新型地毯清洗剂 |
| ES2896402T3 (es) * | 2014-06-27 | 2022-02-24 | Kane Biotech Inc | Composiciones para su uso en la prevención y el tratamiento del crecimiento de biopelículas oftálmicas, de manos o pies |
| CN107375013A (zh) * | 2017-08-25 | 2017-11-24 | 漳浦彩露华化妆品有限公司 | 一种洗卸凝胶及其制备方法 |
| CN107496345A (zh) * | 2017-09-01 | 2017-12-22 | 安庆徽云博冠化妆品科技有限公司 | 一种蛋白螯合洗面奶及其制备方法 |
| CN109998972A (zh) * | 2019-05-17 | 2019-07-12 | 花安堂生物科技集团有限公司 | 一种泡沫丰富洁面泥及其制备方法 |
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