CN117427133A - 一种小儿感冒宁颗粒药物的制备工艺 - Google Patents
一种小儿感冒宁颗粒药物的制备工艺 Download PDFInfo
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Abstract
本发明公开了一种小儿感冒宁颗粒药物的制备工艺,该制备的感冒颗粒由以下原料制成:连翘160克,山腊梅叶200克,防风160克,黄芪80克,白术80克,枇杷叶160克,六神曲40克,麦芽40克,对乙酰氨基酚2~4克,牛磺酸4~6克,本发明中制备的小儿感冒宁颗粒,能够迅速有效地疏散风热,清热止咳,可用于春、秋、冬季小儿感冒发烧。
Description
技术领域
本发明涉及一种颗粒药物的制备工艺,尤其涉及一种小儿感冒宁颗粒药物的制备工艺。
背景技术
小儿感冒,即小儿急性上呼吸道感染,指喉部以上,上呼吸道鼻咽部的急性感染。小儿感冒以病毒为主,此外可能有支原体或细菌感染。幼儿期发病最多,大多表现为流清水样鼻涕、打喷嚏、鼻塞、咳嗽,常伴有发热,体温可高达39℃-40℃,个别患儿还会因发热而引起抽风,或出现腹泻、腹痛、呕吐等症状。目前,对于小儿感冒的治疗主要采用西医和中医治疗。西医一般采用抗生素、激素、非甾体类抗炎药为主,虽起效较快,但副作用较大,严重影响患儿的身心健康;而目前上市的治疗小儿感冒的相关中药制剂,大多提取制备工艺相对简单粗放,药物起效慢,治疗效果不理想,且患儿服药的顺应性差,难以满足临床的用药需求。
鉴于此,本发明选用连翘、山腊梅叶、防风、黄芪、白术、枇杷叶、六神曲、麦芽、对乙酰氨基酚、牛磺酸等十味中药材为原料,通过现代提取制备工艺,制成小儿感冒颗粒,能够迅速有效地疏散风热,清热止咳,可用于春、秋、冬季小儿感冒发烧,汗出不爽,鼻塞流涕,咳嗽咽痛等症。
发明内容
本发明的目的在于解决现有技术中存在的技术问题,提供一种小儿感冒宁颗粒药物的制备工艺。
为实现上述目的,本发明提供的技术方案是:一种小儿感冒宁颗粒药物的制备工艺,该感冒颗粒由以下原料制成:连翘160克,山腊梅叶200克,防风160克,黄芪80克,白术80克,枇杷叶160克,六神曲40克,麦芽40克,对乙酰氨基酚2~4克,牛磺酸4~6克,对乙酰氨基酚优选为3克,牛磺酸优选为5克具体制作工艺包括以下步骤:
步骤(1):连翘,山腊梅叶,防风,黄芪,白术,枇杷叶,六神曲,麦芽混合,加水进行精煎煮,精煎煮液进行过滤、压缩成浸膏;
步骤(2):将步骤(1)中得到的浸膏喷雾干燥得到干膏粉;
步骤(3):再通过干膏粉加辅料和对乙酰氨基酚,牛磺酸,一起制成1000克颗粒药物;
步骤(4):将1000克颗粒药物做成400袋,每袋2.5克。
优选的,步骤(1)中精煎煮包括二次煎煮,第一次煎煮2.5-3h,第二次煎煮1.5-2h,合并两次的煎煮液,得到精煎煮液。
优选的,步骤(2)中喷雾干燥条件为:进风温度为90-100℃,出风温度为70-80℃,雾化压力为0.1-0.3Mpa,喷雾速度为5-10ml/s。
优选的,步骤(3)中辅料为蔗糖、糊精、淀粉、甜菊素、微晶纤维素、硬脂酸镁的一种或多种。
本发明有益效果:
本发明中由连翘、山腊梅叶、防风、黄芪、白术、枇杷叶、六神曲、麦芽、对乙酰氨基酚、牛磺酸等十味中药材为原料制成的小儿感冒宁颗粒,能够迅速有效地疏散风热,清热止咳,可用于春、秋、冬季小儿感冒发烧。
具体实施方式
本部分将详细描述本发明的具体实施例,使人能够直观地、形象地理解本发明的每个技术特征和整体技术方案,但其不能理解为对本发明保护范围的限制。
本发明公开了一种小儿感冒宁颗粒药物的制备工艺,该感冒颗粒由以下原料制成:连翘160克,山腊梅叶200克,防风160克,黄芪80克,白术80克,枇杷叶160克,六神曲40克,麦芽40克,对乙酰氨基酚2-4克,牛磺酸4-6克;对乙酰氨基酚优选为3克,牛磺酸优选为5克.
连翘,别名:落翘、黄花条、黄链条花;性味:性微寒,味苦;功效:清热解毒、消肿散结。
山腊梅叶,别名:亮叶腊梅、毛山茶、岩马桑、香风茶、山蜡梅、臭腊梅、铁筷子、小坝王、秋蜡梅、野蜡梅、雪里花、鸡卵果(《全国中草药汇编》);性味:味辛、微苦,性温功效:祛风解表,芳香化湿。
防风,别名铜芸、回云、回草、百枝、百种;性味:味辛、甘,性微温;功效:祛风解表,胜湿止痛,止痉。
黄芪,别名:绵芪、黄参、血参;性味:味甘,性微温;功效:健脾补中,升阳举陷,益卫固表,利尿,托毒生肌。
白术,别名:于术、冬术、浙术、种术、山蓟、杨抱蓟、术)、山芥、天蓟、山姜、乞力伽、山精、山连、冬白术、杨枹蓟、术;性味:功效:苦、甘,温;补脾,益胃,燥湿,和中,安胎。
枇杷叶,别名:巴叶、芦桔叶;性味:味苦、微辛,性微寒;功效:清肺止咳,和胃降逆,止渴。
六神曲,别名:神曲、六曲;性味:陈腐气,味微苦;功效:健脾和胃,消食调中。
麦芽,别名:麦蘖、大麦毛、大麦芽;性味:甘,平;功效:行气消食,健脾开胃,回乳消胀。
对乙酰氨基酚,别名:N-乙酰对氨基酚、4-乙酰氨基酚;性味:白色结晶或结晶性粉末,无臭;功效:解热镇痛作用。
牛磺酸,别名:牛胆酸、牛胆素;性味:白色或类白色结晶或结晶性粉末,无臭;功效:用于缓解感冒初期的发热。
本发明中由连翘、山腊梅叶、防风、黄芪、白术、枇杷叶、六神曲、麦芽、对乙酰氨基酚、牛磺酸等十味中药材为原料制成的小儿感冒宁颗粒,能够迅速有效地疏散风热,清热止咳,可用于春、秋、冬季小儿感冒发烧。
实施例1
一种小儿感冒宁颗粒药物的制备工艺,该感冒颗粒由以下原料制成:连翘160克,山腊梅叶200克,防风160克,黄芪80克,白术80克,枇杷叶160克,六神曲40克,麦芽40克,对乙酰氨基酚3克,牛磺酸5克,具体制作工艺包括以下步骤:
步骤(1):连翘,山腊梅叶,防风,黄芪,白术,枇杷叶,六神曲,麦芽混合,加水进行精煎煮,精煎煮液进行过滤、压缩成浸膏;精煎煮包括二次煎煮,第一次煎煮2.5-3h,第二次煎煮1.5-2h,合并两次的煎煮液,得到精煎煮液;
步骤(2):将步骤(1)中得到的浸膏喷雾干燥得到干膏粉;喷雾干燥条件为:进风温度为90-100℃,出风温度为70-80℃,雾化压力为0.1-0.3Mpa,喷雾速度为5-10ml/s;
步骤(3):再通过干膏粉加辅料和3克对乙酰氨基酚,5克牛磺酸,一起制成1000克颗粒药物;辅料为蔗糖、糊精、淀粉、甜菊素、微晶纤维素、硬脂酸镁的一种或多种。
步骤(4):将1000克颗粒药物做成400袋,每袋2.5克。
实施例2
一种小儿感冒宁颗粒药物的制备工艺,该感冒颗粒由以下原料制成:连翘160克,山腊梅叶200克,防风160克,黄芪80克,白术80克,枇杷叶160克,六神曲40克,麦芽40克,对乙酰氨基酚2克,牛磺酸4克,具体制作工艺包括以下步骤:
步骤(1):连翘,山腊梅叶,防风,黄芪,白术,枇杷叶,六神曲,麦芽混合,加水进行精煎煮,精煎煮液进行过滤、压缩成浸膏;精煎煮包括二次煎煮,第一次煎煮2.5-3h,第二次煎煮1.5-2h,合并两次的煎煮液,得到精煎煮液;
步骤(2):将步骤(1)中得到的浸膏喷雾干燥得到干膏粉;喷雾干燥条件为:进风温度为90-100℃,出风温度为70-80℃,雾化压力为0.1-0.3Mpa,喷雾速度为5-10ml/s;
步骤(3):再通过干膏粉加辅料和3克对乙酰氨基酚,5克牛磺酸,一起制成1000克颗粒药物;辅料为蔗糖、糊精、淀粉、甜菊素、微晶纤维素、硬脂酸镁的一种或多种。
步骤(4):将1000克颗粒药物做成400袋,每袋2.5克。
实施例3
一种小儿感冒宁颗粒药物的制备工艺,该感冒颗粒由以下原料制成:连翘160克,山腊梅叶200克,防风160克,黄芪80克,白术80克,枇杷叶160克,六神曲40克,麦芽40克,对乙酰氨基酚3克,牛磺酸5克,具体制作工艺包括以下步骤:
步骤(1):连翘,山腊梅叶,防风,黄芪,白术,枇杷叶,六神曲,麦芽混合,加水进行精煎煮,精煎煮液进行过滤、压缩成浸膏;精煎煮包括二次煎煮,第一次煎煮2.5-3h,第二次煎煮1.5-2h,合并两次的煎煮液,得到精煎煮液;
步骤(2):将步骤(1)中得到的浸膏喷雾干燥得到干膏粉;喷雾干燥条件为:进风温度为90-100℃,出风温度为70-80℃,雾化压力为0.1-0.3Mpa,喷雾速度为5-10ml/s;
步骤(3):再通过干膏粉加辅料和4克对乙酰氨基酚,6克牛磺酸,一起制成1000克颗粒药物;辅料为蔗糖、糊精、淀粉、甜菊素、微晶纤维素、硬脂酸镁的一种或多种。
步骤(4):将1000克颗粒药物做成400袋,每袋2.5克。
实施例
取50只健康、体重一致的小白鼠,随机分为五组,测量其体温(记为T1);第二天注射体积浓度15%的鲜酵母生理盐水,使其发热,下午测量其体温(记为T2),其中一组饲喂市面上购买的小儿感冒颗粒,作为对照组,另外四组分别饲喂本发明实施例1-3提供的小儿感冒颗粒,作为实验组;早上(8:00)喂一次药,下午(6:00)喂一次药,按1g/kg的量喂药,连续喂药3天,末次喂药当天的晚上(9:00)测量体温,分别记为T3、T4、T5,结果以平均值表示,如表1所示。
表1
实施例 | 组别 | T1(℃) | T2(℃) | T3(℃) | T4(℃) | T5(℃) |
对照组 | 37.0 | 39.2 | 38.9 | 38.4 | 37.5 | |
实施例1 | 实验组 | 37.1 | 39.4 | 38.0 | 37.0 | 36.9 |
实施例2 | 实验组 | 37.3 | 39.1 | 38.4 | 37.6 | 37.2 |
实施例3 | 实验组 | 37.2 | 39.3 | 38.6 | 37.4 | 37.0 |
从表1可看出,注射鲜酵母生理盐水,各组小鼠体温(T2)均有上升,当饲喂本发明实施例1-3提供的小儿感冒颗粒后,实验组在用药第2天体温即恢复到正常体温(T4),而对照组在用药第3天才恢复到正常体温(T5),由此说明,本发明实施例提供的小儿感冒药具有明显退热效果。
本发明中由连翘、山腊梅叶、防风、黄芪、白术、枇杷叶、六神曲、麦芽、对乙酰氨基酚、牛磺酸等十味中药材为原料制成的小儿感冒宁颗粒,能够迅速有效地疏散风热,清热止咳,可用于春、秋、冬季小儿感冒发烧。
在不出现冲突的前提下,本领域技术人员可以将上述附加技术特征自由组合以及叠加使用。
以上所述仅为本发明的优先实施方式,只要以基本相同手段实现本发明目的的技术方案都属于本发明的保护范围之内。
Claims (4)
1.一种小儿感冒宁颗粒药物的制备工艺,其特征在于:该感冒颗粒由以下原料制成:连翘160克,山腊梅叶200克,防风160克,黄芪80克,白术80克,枇杷叶160克,六神曲40克,麦芽40克,对乙酰氨基酚2~4克,牛磺酸4~6克,具体制作工艺包括以下步骤:
步骤(1):连翘,山腊梅叶,防风,黄芪,白术,枇杷叶,六神曲,麦芽混合,加水进行精煎煮,精煎煮液进行过滤、压缩成浸膏;
步骤(2):将步骤(1)中得到的浸膏喷雾干燥得到干膏粉;
步骤(3):再通过干膏粉加辅料和对乙酰氨基酚,牛磺酸,一起制成1000克颗粒药物;
步骤(4):将1000克颗粒药物做成400袋,每袋2.5克。
2.根据权利要求1所述的一种小儿感冒宁颗粒药物的制备工艺,其特征在于:步骤(1)中精煎煮包括二次煎煮,第一次煎煮2.5-3h,第二次煎煮1.5-2h,合并两次的煎煮液,得到精煎煮液。
3.根据权利要求1所述的一种小儿感冒宁颗粒药物的制备工艺,其特征在于:步骤(2)中喷雾干燥条件为:进风温度为90-100℃,出风温度为70-80℃,雾化压力为0.1-0.3Mpa,喷雾速度为5-10ml/s。
4.根据权利要求1所述的一种小儿感冒宁颗粒药物的制备工艺,其特征在于:步骤(3)中辅料为蔗糖、糊精、淀粉、甜菊素、微晶纤维素、硬脂酸镁的一种或多种。
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