CN1174052A - Use of cajanus cajan medicine - Google Patents
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- CN1174052A CN1174052A CN 97108820 CN97108820A CN1174052A CN 1174052 A CN1174052 A CN 1174052A CN 97108820 CN97108820 CN 97108820 CN 97108820 A CN97108820 A CN 97108820A CN 1174052 A CN1174052 A CN 1174052A
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Abstract
The present invention discloses the new use of cajanus cajan leaf as material for preparing medicine for curing ischemic necrosis of thighbone head. The present invention has the functions of preventing microcirculation, promoting blood vessel regeneration, penetrating proliferated sclerotic layer around necrotic thighbone region and entering the center of thighbone to absorb necrotic bone and regenerate new bone, so that it has specific effect to curing necrosis of thighbone head.
Description
The invention belongs to a kind of new purposes of cajanus cajan medicine.
Folium Cajani [Cajanus Cajan (L) Millsp has another name called the willow bean, turns round bean, fine bean mash (Guangzhou), willow point (Chengmai)] has the effect of refreshing and detoxicating, blood circulation promoting and blood stasis dispelling, anti-inflammation, this medicine root has heat-clearing and toxic substances removing, hemostasis and pain-relieving and insecticidal action, tender leaf is chewed the mashed aphtha that is used for the treatment of, press the juice jaundice that can disappear for oral administration, the juice of mashing has the putrefaction-removing granulation-promoting effect to wound and sore, the decoct of leaf is effective to cough, diarrhoea etc., so Folium Cajani is in the treatment wound, burn sense beam and decubital ulcer etc. obtain curative effect preferably.But use it for other disease of treatment, yet there are no report.
The object of the present invention is to provide a kind of new purposes of cajanus cajan medicine, be used for the treatment of ischemic necrosis of femoral head.
The present invention is achieved in that Folium Cajani is used to prepare the purposes of the medicine for the treatment of ischemic necrosis of femoral head.
Below in conjunction with embodiment and accompanying drawing the present invention is described in detail.
Example one: Zhu No.5018 Yin Lei, man, 20 years old, address: No. one two Unit 2, Building Room 302 of Buddhist nunnery, wonderful peak, east, Nanjing.
Excuse pain three days was successively examined to the hospitalize of the local military region and was central nervous system infection, brain stem encephalitis on February 17th, 93.During this period, successively obeyed dexamethasone, prednisone 950mg.On October 27th, 93 occurred skelalgia in, November 8, the right lower extremity difficulty in walking had limping, and sb.'s illness took a turn for the worse.District hospital of Nikkei army examined and was the bilateral femoral head necrosis 94 year February 4, and suggestion is made replacement operation of artificial femoral head and is not accepted, mail-order MUDOUYE HUOGU WAN expectant treatment for oral administration.
Bilateral femoral head normotopia X-ray sheet before Fig. 1 is to take medicine, X line show that the both sides femoral head sees irregular big lucent area, account for complete more than 2/3, and the joint space does not have obvious change.
Fig. 2 is four months bilateral femoral head normotopia X-ray sheets of taking medicine, and the X line shows takes medicine three months bed activitieses freely, painless, takes medicine four months, and capsule becomes the district to be dwindled, and bone density increases.
Fig. 3 is seven months bilateral femoral head normotopia X-ray sheets of taking medicine.
Fig. 4 is seven months bilateral femoral head frog position X-ray sheets of taking medicine, and seven months capsules of taking medicine become the district further to be dwindled, speckle skeletonization in the district, and bone density increases, and " meniscus sign " under the cartilage seen on the right side.
Fig. 5 is ten months bilateral femoral head normotopia X-ray sheets of taking medicine.
Fig. 6 is ten months bilateral femoral head frog position X-ray sheets of taking medicine, and ten months pain of taking medicine disappears, and hip joint is flexibly movable, and Nang Qu further dwindles, and bifilar bone is clear.
Fig. 7 is 13 months bilateral femoral head normotopia X-ray sheets of taking medicine.
Fig. 8 is 13 months bilateral femoral head frog position X-ray sheets of taking medicine, take medicine ten March bone density further increase, head circumference, the head in the replacement bone lucent area is still arranged.
Fig. 9 for take medicine ten August bilateral femoral head normotopia X-ray sheet.
Figure 10 is 18 months bilateral femoral head frog position X-ray sheets of taking medicine, and 18 months complete the density of taking medicine is more even, and the replacement bone district is arranged, and the bone trabecula growth reaches clinical cure substantially, recovers light work.
Example two: No.5006, Wang Qiang, man 40 years old, address: Jiaxing City, Zhejiang Province public security bureau.
Be addicted to drink 30 years, because of excessive drinking, 93 years right hips pain occurs and took the prednisone pain relieving 1 year.Find femur head necrosis through hospital of the local Armed Police contingent in March, 94, and April in the same year, I treated at institute's mail-order MUDOUYE HUOGU WAN.
Figure 11 is bilateral femoral head normotopia X-ray sheet before taking medicine.
Bilateral femoral head frog position X-ray sheet before Figure 12 is to take medicine, X line show that the full head of right femoral head is downright bad, and big portion subsides, in have the little sequestrum in many places alternate with the granulation district, the bulk sequestrum is arranged at the top, complete the necrosis in left side subsided, in be the bulk sequestrum, head and neck cross-connecting area formation granulation band.Be diagnosed as: bilateral femoral head necrosis (left IIIB, right IIIB).
Figure 13 is four months bilateral femoral head normotopia X-ray sheets of taking medicine.
Figure 14 is four months bilateral femoral head frog position X-ray sheets of taking medicine, and month state of an illness of taking medicine makes moderate progress, and sequestrum absorbs gradually, four months bifilar bone of taking medicine becomes circle, and sequestrum absorbs, based on intramembranous ossification, bone density obviously increases, and pain obviously alleviates, and hip joint is movable lax.
Figure 15 is nine months bilateral femoral head normotopia X-ray sheets of taking medicine, and nine months left side sequestrums of taking medicine absorb, based on intramembranous ossification, and increase in density, bone trabecula forms, skeletonization in the head capsule district, bone density increases holds up ground activity under the crutches, takes medicine and resumes work in 1 year.
Example three: No.5126, yellow jasper, woman 52 years old, address: Yamti Halim Kakap No26 Jeluk Batung Bandac Lamung ndoneia.
Because of two renal failures produced the kidney rejection phenomenon on June 30th, 1993 after Indonesia makes renal transplantation, cause the bilateral femoral head necrosis because of taking hormone, on March 26th, 1994 was done the artificial hip in left side at Ya Jiada, and postoperative function is poor.
Came my institute's treatment on August 11st, 1994,, take hormone and cause body nihility method to carry out the blood vessel implantation, change expectant treatment into, take MUDOUYE HUOGU WAN because of patient's kidney has rejection.
Figure 16 is bilateral femoral head normotopia X-ray sheet before taking medicine, and the X line shows that the full head of right femoral head is downright bad, and head and neck junction bone density is the analysis of strip sequestrum in the middle of lowering head.
Figure 17 is three months right lateral thigh bone normotopia X-ray sheets of taking medicine, and three months right sequestrums of taking medicine absorb, and the kidney rejection phenomenon disappears.The X line shows and is the new bone formation of flocculence in the head, and bone density increases, and the sequestrum band is most of under the cartilage absorbs.
Figure 18 is seven months right lateral thigh bone normotopia X-ray sheets of taking medicine, the right sequestrum hypersorption in seven months of taking medicine, and bone density increases, and bone trabecula forms, and hip is painless, and renal function is kept normally, and health status is obviously improved.
Figure 19 is the 1 year right lateral thigh bone normotopia X-ray sheet of taking medicine, and the 1 year right sequestrum of taking medicine absorbs fully, replacement bone, full skull increase in density, head replacement bone.
Figure 20 took medicine 16 months for 16 months right lateral thigh bone normotopia X-ray sheets of taking medicine, and is painless, is clearly better, immunity of organism strengthens, and renal function is normal, the tourism of going to U.S.A., healthy, the bone ball energy enhancing human body immunity power of living is described, and the kidney immunologic rejection is had obvious effect.
Example four: No.5099, Shen Lang, man, 50 years old, address: No. 136, door street, the Cixi City Hu Shan south of a town, Zhejiang Province.
In May, 88, because of the shared dexamethasone 3600mg of anaphylactoid purpura, prednisone 5400mg also took hormone before curing the disease, and in October, 93 occurred left hip pain, lived femur head necrosis center expectant treatment on August 25th, 94.
Figure 21 is a bilateral femoral head normotopia X-ray sheet, and the X line shows that femoral head full head in left side is downright bad, has and subsides, and there is the granulation district head and neck junction, has large stretch of sequestrum to present in the right lateral thigh bone, examines to be bilateral femoral head necrosis (left IIIA, right IIA).Conscious good after taking medicine, pain obviously alleviates, and movable function strengthens, and former work is recovered in the back of leaving hospital, and continues to take medicine.
Figure 22 is ten months bilateral femoral head normotopia X-ray sheets of taking medicine.
Figure 23 is ten months bilateral femoral head frog position X-ray sheets of taking medicine, and ten months capsules of taking medicine become the district to be dwindled, and bone density increases, and bone trabecula evenly occurs, the head circle.
Figure 24 is a year and a half bilateral femoral head normotopia X-ray sheet of taking medicine.
Figure 25 is a year and a half bilateral femoral head frog position X-ray sheet of taking medicine, and a year and a half of taking medicine, two hips did not have pain, the head circle, and based on intramembranous ossification, sequestrum is finished absorption, the bone trabecula growth, the part replacement bone reaches clinical cure substantially.
Figure 26 is the function picture.
Example five: No.5078, the son of Zhang Shuguo, man, 11 years old, address: Zhang village, west, Henan envelope Lou Di township, Qiu Xian.
In May, 93, left side hip pain had limping, failed to respond to any medical treatment in the locality, satisfied letter, and X-ray film requirement medication treatment, and this moment, infant was ill ten months.
Figure 27 is bilateral femoral head normotopia X-ray sheet before taking medicine, and the X line shows a left side burst epiphysis total necrosis, and head presents flat, does the back acrocyst and sexually revises, and is diagnosed as children's's femur head necrosis (left side III～IV phase).
Figure 28 is back three months bilateral femoral head normotopia X-ray sheets of taking medicine, and three months left strand of epiphysis sequestrums of taking medicine are cracked, begins to absorb, and acrocyst change district, dried back density is cloud and increases.
Figure 29 is six months bilateral femoral head normotopia X-ray sheets of taking medicine, and six a months left side strand epiphysis sequestrums of taking medicine continue to absorb, and dried back acrocyst becomes the district slightly to be dwindled, and bone trabecula forms.
Figure 30 is nine months bilateral femoral head normotopia X-ray sheets of taking medicine, nine months most of absorptions of a left side strand epiphysis sequestrum of taking medicine, and replacement bone is obvious, does the rear end increase in density, and bone trabecula obviously forms.
Figure 31 is the 1 year bilateral femoral head normotopia X-ray sheet of taking medicine, and the 1 a year left side strand epiphysis sequestrum of taking medicine all absorbs, and replacement bone is obvious, does the rear end increase in density, and skeletonization is obvious.
Figure 32 absorbs fully for 15 months left side femoral head normotopia X-ray sheets of taking medicine, 15 a months left side strand epiphysis sequestrums of taking medicine, and skeletonization is obvious, does the rear end and continues skeletonization, cures near basic.
One, Folium Cajani is used for the treatment of the preparation of the medicine of ischemic necrosis of femoral head:
70 parts of Folium Cajanis, 10 parts of Radix Astragali, 10 parts of Rhizoma Chuanxiongs, 5 parts of Hippocampus, 5 parts of Rhizoma Drynariae feed intake by ratio, and alcohol extraction is refined into granule, encapsulated 0.3g/ grain.
Two, MUDOUYE HUOGU WAN (having another name called Yuan Shi bone ball alive) clinical observation on the therapeutic effect (102 example)
The MUDOUYE HUOGU WAN main component is a Folium Cajani.Clinical verification through coming 2 years verifies that wherein case has clinical observation in hospital and mail-order medicine clinical verification two parts more.Now preliminary above case 102 examples mail-order two courses of treatment of medicine (100 days per courses of treatment) (wherein 47 examples are the downright bad patient of bilateral femoral head) of summing up.Divide excellent, good, can, the assessment of difference level Four.
Clinical data
Sex men and women
Number 69 33
Accounting example 67.6% 32.4%
Age cohorts
＜10 10-20 21-40 41-60 61-80
Number 12 8 32 41 9
Paathogenic factor
Wound ethanol hormone children's femur head necrosis osteoarthritis unknown cause number 30 28 23 14 34
Sick hip aging schedule
I II III IV V VI by stages
Hip several 7 49 76 15 20
Add up to 149 (wherein 47 examples are the downright bad patient of bilateral femoral head)
Curative effect and the course of treatment correlation table
The course of treatment/grade is good poor
First course of treatment
Second course of treatment 15 21
The 3rd course of treatment 4 22 1
The 4th course of treatment 581
The 5th course of treatment 662
The 6th course of treatment 83
Amount to 23 54 25
Accounting for percentage ratio 22.5% 53% 24.5% discusses:
(1) take MUDOUYE HUOGU WAN, doing well,improving is very fast.Take medicine two to around, the patient promptly has pain relief, function of joint takes a turn for the better.Took medicine three months, and felt obviously to alleviate.The 1 year pain of taking medicine disappears substantially, and activity more freely.General one to a year and a half can be recovered light industry.
(2) this medicine is not only effective in early days to I, II, III, and to III late period, the IV V VI phase is all effective, but can't change the femoral head of distortion.More about three to four years of patients with terminal reparation.
(3) took medicine two to three months, X-ray film can present the phenomenon of reparation.Sequestrum absorbs, and bright zone increases, the prompting replacement bone.Zona pellucida and sequestrum district bone density increase or the bone texture presents strip on every side, flocculence is dispersed in bone density and increases, the prompting intramembranous ossification, sometimes the bone density of hypertrophy hardenability band lowers, gradually clear, and transparent granulation band is fuzzy, increase in density is risen to crown sequestrum as cloud, this all points out, the outer blood capillary of hypertrophy hardenability band is passed the sclerosis parietal layer and is entered aged granulation district, makes the ability of recovering skeletonization, proves that this medicine is effective.The speed of sequestrum absorption → replacement bone or intramembranous ossification process proves the curative effect of medication degree.Transparent capsule change district will be distinguished with the self-dissolving district and the replacement bone district of necrotic bone piece under joint fluid soaks in the necrotic area.The method of its differentiation has two: 1. capsule becomes the district cyst wall, and the replacement bone district does not then have.2. the replacement bone district engendered calcification point after two to three months, and other the two all do not have this phenomenon.MUDOUYE HUOGU WAN experimental results show that from animal: have the blood capillary of impelling and with matched group significant difference P＞0.01 is arranged to the ischemic region growth.Therefore, take medicine downright bad femoral head is reached face art substantially and cure.
(4) from our a large amount of clinical practices (take medicine observe example surplus the case 800, THE ARTIFICIAL POLYESTER DILUN 1200 surplus example), fact proved: femur head necrosis is not irreversible, key is to depend on and the supply of blood fortune, has sufficient blood fortune can promote to make downright bad pathological changes to reverse, otherwise otherwise.In the therapeutic process of femur head necrosis, to note handling well two pairs of contradictions; The one, repair and blood fortune; The 2nd, the compressive stress of body weight and capital mechanical strength; Blood fortune is the main aspect of principal contradiction.
Capital mechanical strength is constantly to change along with the main pattern of the variation of blood confession and capital skeletonization, we will take appropriate measures at any time and prevent capital subsiding, increase capital support strength again, that will be by means of operation, implant sartorius m. flesh muscle flap, the inducible factor of bone and vascular bundle supply and a mechanical strength to improve blood faster, strive for repairing about a year and a half.
(5) can see that from example three this medicine plays dual regulation in immunoreation.It has the gathering macrophage zoopery proof, increases phagocytic activity, promote thymus cortex hypertrophy, but it can restrain the rejection effect of transplanted kidney again.Behind example three transplanted kidney, come immunologic rejection and cause capital necrosis, left side to change the greatest service recovering dissatisfied and seek medical advice with hormone.Low in view of Abwehrkraft des Koepers, abandon the blood vessel implantation, use bone ball alive instead and carry out expectant treatment.The two all right hip pain of taking medicine obviously alleviate, the hormone of stopping using, and renal function returns to normally gradually, and spiritual muscle power has improvement greatly, the very fast reparation of femur head necrosis, sequestrum absorbs fully, replacement bone, bone density constantly increases.Take medicine and reach clinical basic healing three courses of treatment.The tourism of just going to U.S.A. in 9 months of taking medicine.
The old man in year surplus in the of (six) 70 to 80, taking medicine improves femur head necrosis, and the whole body osteoporosis all is improved, bone density increases.To the degeneration osteoarthritis is to cause in chronic gastropathy to obtain curing (situations of a lot of similar examples six).Efficacy assessment standard
Excellent: 1. patient main suit's symptom is obviously improved or is painless substantially, and hip joint is flexibly loosening, can go to turn action.
2. X line oblatio: sequestrum all absorbs, and bone density obviously increases, and crown fritter replacement bone is only arranged.This is clinical basic healing.
Good level: 1. symptom is obviously improved, some hypodynia still, and the hip joint activity feels more loosening, but still need turn the protection femoral head.
2. big sequestrum of X line oblatio absorbs and still remains with a small amount of sequestrum, enters the replacement bone stage.The incidence bone density evenly increases, and bone trabecula is clear.
Can level: 1. conscious clinical symptoms makes moderate progress, and pain is still arranged, and needs protection in addition.
2. X line oblatio: sequestrum partially absorbs, and bone density slightly increases or lowers.
The difference level: 1. subjective symptoms does not have improvement or increases the weight of, and hip joint function descends.
2. X line oblatio: femur head necrosis does not have and improves or development is arranged, and it is more obvious to subside.
Annotate: the treatment of other places mail-order medicine, function of joint can't quantize, can only be by its main suit and the X line major parameter as efficacy evaluation.Also can be excellent, good with reference to the self assessment of its subjective symptoms, can, the rank of difference.
From above-mentioned example as can be known, the present invention has the protection microcirculation, promotes angiogenesis, passes femur necrosis district hypertrophy hardened layer on every side, enters the sequestrum center and absorbs the effect that sequestrum is rebuild new bone, and the treatment femur head necrosis is played specific effect.
Claims (1)
1. the purposes of a cajanus cajan medicine, it is characterized in that: Folium Cajani is used to prepare the purposes of the medicine for the treatment of ischemic necrosis of femoral head.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN97108820A CN1069042C (en) | 1997-01-28 | 1997-01-28 | Use of cajanus cajan medicine |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN97108820A CN1069042C (en) | 1997-01-28 | 1997-01-28 | Use of cajanus cajan medicine |
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| CN1174052A true CN1174052A (en) | 1998-02-25 |
| CN1069042C CN1069042C (en) | 2001-08-01 |
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|---|---|---|---|
| CN97108820A Expired - Fee Related CN1069042C (en) | 1997-01-28 | 1997-01-28 | Use of cajanus cajan medicine |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000078324A1 (en) * | 1999-06-18 | 2000-12-28 | Hao Yuan | The leaves of cajanus cajan(l.) millsp and extract, formulation and uses thereof |
| CN100363021C (en) * | 2005-11-04 | 2008-01-23 | 浙江海正药业股份有限公司 | Use of cajan seed and its extract in preparing medicine for treating osteal arthritis |
| CN100413514C (en) * | 1999-06-18 | 2008-08-27 | 袁浩 | Leaves of cajanus cajan(L.) millsp and extract, formulation and uses thereof |
| CN100423755C (en) * | 2005-02-04 | 2008-10-08 | 张海峰 | Chinese medicine preparation for treating bone fracture and preparing method thereof |
| WO2010094760A1 (en) * | 2009-02-23 | 2010-08-26 | Dsm Ip Assets B.V. | Cajanus extracts and glucosamine for inflammatory disorders |
| CN101879261A (en) * | 2010-06-23 | 2010-11-10 | 王平 | Medicinal paste for treating ischemic necrosis in head of femur |
| CN102755309A (en) * | 2012-06-19 | 2012-10-31 | 暨南大学 | Application of cajanin to preparation of medicament for treating or preventing caput femoris necrosis |
| CN104605429A (en) * | 2015-01-27 | 2015-05-13 | 福建省农业科学院作物研究所 | Method for preparing pigeon pea pod health drink |
-
1997
- 1997-01-28 CN CN97108820A patent/CN1069042C/en not_active Expired - Fee Related
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000078324A1 (en) * | 1999-06-18 | 2000-12-28 | Hao Yuan | The leaves of cajanus cajan(l.) millsp and extract, formulation and uses thereof |
| US6797285B1 (en) | 1999-06-18 | 2004-09-28 | Hao Yuan | Leaves of Cajanus Cajan(L.) Millsp and extract, formulation and uses thereof |
| CN100413514C (en) * | 1999-06-18 | 2008-08-27 | 袁浩 | Leaves of cajanus cajan(L.) millsp and extract, formulation and uses thereof |
| CN100423755C (en) * | 2005-02-04 | 2008-10-08 | 张海峰 | Chinese medicine preparation for treating bone fracture and preparing method thereof |
| CN100363021C (en) * | 2005-11-04 | 2008-01-23 | 浙江海正药业股份有限公司 | Use of cajan seed and its extract in preparing medicine for treating osteal arthritis |
| WO2010094760A1 (en) * | 2009-02-23 | 2010-08-26 | Dsm Ip Assets B.V. | Cajanus extracts and glucosamine for inflammatory disorders |
| CN101879261A (en) * | 2010-06-23 | 2010-11-10 | 王平 | Medicinal paste for treating ischemic necrosis in head of femur |
| CN102755309A (en) * | 2012-06-19 | 2012-10-31 | 暨南大学 | Application of cajanin to preparation of medicament for treating or preventing caput femoris necrosis |
| CN102755309B (en) * | 2012-06-19 | 2014-03-05 | 暨南大学 | Application of cajanin to preparation of medicament for treating or preventing caput femoris necrosis |
| CN104605429A (en) * | 2015-01-27 | 2015-05-13 | 福建省农业科学院作物研究所 | Method for preparing pigeon pea pod health drink |
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|---|---|
| CN1069042C (en) | 2001-08-01 |
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